babesia bovis

Summary

Summary: A species of protozoa that is a cause of bovine babesiosis. Ticks of the genera Boophilus, Rhipicephalus, and IXODES are the chief vectors.

Top Publications

  1. ncbi Babesia bovis: adhesion of parasitized red blood cells to bovine umbilical vein endothelial cells in vitro does not select for virulence
    John B Molloy
    Department of Primary Industries Queensland, Agency for Food and Fibre Sciences, 665 Fairfield Road, Yeerongpilly, Queensland 4105, Australia
    Exp Parasitol 103:182-4. 2003
  2. ncbi Advances in the development of molecular tools for the control of bovine babesiosis in Mexico
    J Mosqueda
    Bovine Babesiosis Laboratory, National Center for Disciplinary Research in Veterinary Parasitology CENID PAVET INIFAP, Jiutepec, Morelos, Mexico
    Parassitologia 49:19-22. 2007
  3. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
  4. ncbi Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription
    Basima Al-Khedery
    Department of Pathobiology, University of Florida, Gainesville, 32611, USA
    Mol Microbiol 59:402-14. 2006
  5. pmc Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level
    Audrey Ot Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and Paul G, Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, USA
    BMC Genomics 12:410. 2011
  6. pmc Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast
    Marina C Caballero
    Program of Genomics, Department of Veterinary Microbiology and Pathology and Paul G Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 181:125-33. 2012
  7. ncbi Detection of bovine babesiosis in Mozambique by a novel seminested hot-start PCR method
    Tiago M Martins
    UTPAM, INETI, Est Paço do Lumiar 1649 038 Lisboa, Portugal
    Vet Parasitol 153:225-30. 2008
  8. ncbi A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites
    Jeanne M Freeman
    USDA ARS, Knipling Bushland U S Livestock Insects Research Laboratory, 2700 Fredericksburg Rd Kerrville, TX 78028, USA
    Vet Parasitol 173:211-8. 2010
  9. ncbi Development of a tandem repeat-based multilocus typing system distinguishing Babesia bovis geographic isolates
    Agustina Perez-Llaneza
    Institute of Pathobiology, CICVyA, INTA Castelar, Buenos Aires, Argentina
    Vet Parasitol 167:196-204. 2010
  10. ncbi Recent insights into alteration of red blood cells by Babesia bovis: moovin' forward
    Sejal Gohil
    Department of Microbiology, Monash University, Victoria, Australia
    Trends Parasitol 26:591-9. 2010

Detail Information

Publications209 found, 100 shown here

  1. ncbi Babesia bovis: adhesion of parasitized red blood cells to bovine umbilical vein endothelial cells in vitro does not select for virulence
    John B Molloy
    Department of Primary Industries Queensland, Agency for Food and Fibre Sciences, 665 Fairfield Road, Yeerongpilly, Queensland 4105, Australia
    Exp Parasitol 103:182-4. 2003
  2. ncbi Advances in the development of molecular tools for the control of bovine babesiosis in Mexico
    J Mosqueda
    Bovine Babesiosis Laboratory, National Center for Disciplinary Research in Veterinary Parasitology CENID PAVET INIFAP, Jiutepec, Morelos, Mexico
    Parassitologia 49:19-22. 2007
    ..bovis, we are identifying genes than allow us to discriminate isolates using molecular tools...
  3. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
    b>Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health and economic development...
  4. ncbi Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription
    Basima Al-Khedery
    Department of Pathobiology, University of Florida, Gainesville, 32611, USA
    Mol Microbiol 59:402-14. 2006
    Antigenic variation in Babesia bovis is one aspect of a multifunctional virulence/survival mechanism mediated by the heterodimeric variant erythrocyte surface antigen 1 (VESA1) protein that also involves endothelial cytoadhesion with ..
  5. pmc Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level
    Audrey Ot Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and Paul G, Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, USA
    BMC Genomics 12:410. 2011
    ..We investigated the mechanisms of virulence loss at the whole genome level using Babesia bovis as a model apicomplexan in which genetically related attenuated parasites can be reliably derived from ..
  6. pmc Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast
    Marina C Caballero
    Program of Genomics, Department of Veterinary Microbiology and Pathology and Paul G Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 181:125-33. 2012
    ..pathways between parasites that have both common and unique stages, we characterized the apicoplast in Babesia bovis, which has only intraerythrocytic asexual stages in the mammalian host, and compared it to that of Plasmodium ..
  7. ncbi Detection of bovine babesiosis in Mozambique by a novel seminested hot-start PCR method
    Tiago M Martins
    UTPAM, INETI, Est Paço do Lumiar 1649 038 Lisboa, Portugal
    Vet Parasitol 153:225-30. 2008
    ..Here, we present the detection of Babesia bigemina and Babesia bovis in cattle from Mozambique using two distinct PCR methods...
  8. ncbi A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites
    Jeanne M Freeman
    USDA ARS, Knipling Bushland U S Livestock Insects Research Laboratory, 2700 Fredericksburg Rd Kerrville, TX 78028, USA
    Vet Parasitol 173:211-8. 2010
    Completion of the Babesia bovis (T2Bo strain) genome provides detailed data concerning the predicted proteome of this parasite, and allows for a bioinformatics approach to gene discovery...
  9. ncbi Development of a tandem repeat-based multilocus typing system distinguishing Babesia bovis geographic isolates
    Agustina Perez-Llaneza
    Institute of Pathobiology, CICVyA, INTA Castelar, Buenos Aires, Argentina
    Vet Parasitol 167:196-204. 2010
    ..In the present work we have searched the genome of the tick-transmitted bovine hemoprotozoon Babesia bovis for tandem repeats (TRs) that could be useful for a multilocus typing system...
  10. ncbi Recent insights into alteration of red blood cells by Babesia bovis: moovin' forward
    Sejal Gohil
    Department of Microbiology, Monash University, Victoria, Australia
    Trends Parasitol 26:591-9. 2010
    ..Here, we bring together recent work on Babesia bovis parasites which are beginning to unravel the molecular mechanisms that underlie the pathogenesis of babesiosis ..
  11. ncbi Immunity following use of Australian tick fever vaccine: a review of the evidence
    R E Bock
    Tick Fever Research Centre, Animal and Plant Health Service, Queensland Department of Primary Industries, Wacol
    Aust Vet J 79:832-9. 2001
    To review the evidence available on the degree and duration of immunity provided by Australian tick fever vaccines against Babesia bovis, B. bigemina and Anaplasma marginale infections in Australia and overseas.
  12. pmc Persistently infected calves as reservoirs for acquisition and transovarial transmission of Babesia bovis by Rhipicephalus (Boophilus) microplus
    Jeanne M Howell
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Clin Microbiol 45:3155-9. 2007
    b>Babesia bovis is a deadly disease of cattle resulting in severe economic losses in the vast regions of the world where it is endemic...
  13. ncbi The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface
    D R Allred
    Department of Pathobiology, University of Florida, Gainesville 32611, USA
    Mol Cell 5:153-62. 2000
    ..Variation appears to involve creation and modification or loss of a novel, transcribed copy of the gene...
  14. ncbi Babesia bovis: a comprehensive phylogenetic analysis of plastid-encoded genes supports green algal origin of apicoplasts
    Audrey O T Lau
    Program in Genomics, Department of Veterinary Microbiology and Pathology, School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Exp Parasitol 123:236-43. 2009
    ..The results also substantiate earlier findings that plastids found in Heterokonts such as Odontella and Thalassiosira were derived from a separate secondary endosymbiotic event likely originating from a red algal lineage...
  15. pmc The Babesia bovis merozoite surface antigen 1 hypervariable region induces surface-reactive antibodies that block merozoite invasion
    Tanya LeRoith
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 74:3663-7. 2006
    A hypervariable region (HVR) previously identified in the carboxy-terminal one-third of the Babesia bovis variable merozoite surface antigen family was more extensively analyzed in merozoite surface antigen 1 (MSA-1) from 16 strains and ..
  16. ncbi Development and evaluation of a nested PCR based on spherical body protein 2 gene for the diagnosis of Babesia bovis infection
    Mahmoud Aboulaila
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Vet Parasitol 169:45-50. 2010
    We developed and evaluated a nested PCR assay for the diagnosis of Babesia bovis infection in cattle based on the spherical body protein 2 gene (SBP2) from B. bovis. The specificity and sensitivity of the test were compared with the B...
  17. ncbi First survey for Babesia bovis and Babesia bigemina infection in cattle from Central and Southern regions of Portugal using serological and DNA detection methods
    Marta G Silva
    Biomolecular Diagnostic Laboratory, ITQB IBET, Universidade Nova de Lisboa, Av da Republica, apt 12, 2781 901 Oeiras, Portugal
    Vet Parasitol 166:66-72. 2009
    Incidence of bovine babesiosis in Portugal is currently unknown. In this study, a first survey of Babesia bovis and Babesia bigemina infection in cattle was carried out using blood samples from 406 clinically healthy individuals from ..
  18. ncbi Bovine piroplasms in Minorca (Balearic Islands, Spain): a comparison of PCR-based and light microscopy detection
    S Almeria
    Parasitology, Faculty Veterinary Medicine, Autonomous University of Barcelona, Barcelona, Spain
    Vet Parasitol 99:249-59. 2001
    ..0% of the studied animals were infected), while one animal (0.75%) was found to be infected by Babesia bovis. It was observed that 31% of animals infected with B. bigemina had a concurrent infection of T. annulata...
  19. pmc Universal primers suitable to assess population dynamics reveal apparent mutually exclusive transcription of the Babesia bovis ves1alpha gene
    Agata K Zupańska
    Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611 0880, USA
    Mol Biochem Parasitol 166:47-53. 2009
    b>Babesia bovis is an intraerythrocytic hemoparasite of widespread distribution, which adversely affects livestock production in many regions of the world...
  20. pmc Analysis of Babesia bovis infection-induced gene expression changes in larvae from the cattle tick, Rhipicephalus (Boophilus) microplus
    Andrew M Heekin
    Knipling Bushland US Livestock Insect Research Laboratory, USDA ARS, 2700 Fredericksburg Rd, Kerrville, TX 78028, USA
    Parasit Vectors 5:162. 2012
    ..The most severe form of the disease is caused by the apicomplexan, Babesia bovis, and transmitted to cattle through the bite of infected cattle ticks of the genus Rhipicephalus, with the most ..
  21. pmc The Babesia bovis merozoite surface antigen 2 locus contains four tandemly arranged and expressed genes encoding immunologically distinct proteins
    Monica Florin-Christensen
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:3566-75. 2002
    Members of the variable merozoite surface antigen (vmsa) gene family of Babesia bovis encode membrane proteins involved in erythrocyte invasion. In this study, we have identified and sequenced the complete 8...
  22. ncbi An amino acid substitution in the Babesia bovis dihydrofolate reductase-thymidylate synthase gene is correlated to cross-resistance against pyrimethamine and WR99210
    Fasila R Gaffar
    Division of Parasitology and Tropical Veterinary Medicine, Institute of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1 3584 CL Utrecht, The Netherlands
    Mol Biochem Parasitol 133:209-19. 2004
    The genomic locus and cDNA encoding Babesia bovis dihydrofolate reductase-thymidylate synthase (DHFR-TS) were cloned and sequenced...
  23. ncbi New insights into the altered adhesive and mechanical properties of red blood cells parasitized by Babesia bovis
    Claire L Hutchings
    Department of Microbiology, Monash University, Victoria, Australia
    Mol Microbiol 65:1092-105. 2007
    ..cells (RBCs) in the microvasculature is an important pathological feature of both bovine babesiosis caused by Babesia bovis and human malaria caused by Plasmodium falciparum...
  24. ncbi Genetic conservation of potentially immunogenic proteins among Brazilian isolates of Babesia bovis
    Carlos A N Ramos
    Laboratório de Doenças Parasitárias dos Animais Domésticos, Departamento de Medicina Veterinária UFRPE, Recife, PE 52171 900, Brazil
    Vet Parasitol 187:548-52. 2012
    Bovine babesiosis caused by Babesia bovis remains an important constraint for the development of cattle industries worldwide. Effective control can be achieved by vaccination with live attenuated phenotypes of the parasite...
  25. pmc Expression and strain variation of the novel "small open reading frame" (smorf) multigene family in Babesia bovis
    Lucas M Ferreri
    Department of Veterinary Microbiology and Pathology and School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6040, USA
    Int J Parasitol 42:131-8. 2012
    Small open reading frame (smorf) genes comprise the second largest Babesia bovis multigene family...
  26. pmc Monitoring Babesia bovis infections in cattle by using PCR-based tests
    J A Calder
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32611, USA
    J Clin Microbiol 34:2748-55. 1996
    The sensitivity and specificity of PCR tests based on the small-subunit rRNA gene sequence of Babesia bovis were compared in a blind study of experimentally infected cattle with the corresponding parameters of the complement fixation (CF)..
  27. ncbi Live vaccines against bovine babesiosis
    D T De Waal
    Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Parasitol 138:88-96. 2006
    Bovine babesiosis is an important tick-borne disease caused by Babesia bovis, B. bigemina and B. divergens...
  28. ncbi Population genetic analysis and sub-structuring in Babesia bovis
    Martin Simuunza
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Mol Biochem Parasitol 177:106-15. 2011
    The tick-borne protozoan parasite, Babesia bovis is one of the causes of bovine babesiosis, an economically important disease of cattle in tropical and sub-tropical countries...
  29. ncbi Development and evaluation of two nested PCR assays for the detection of Babesia bovis from cattle blood
    Mahmoud Aboulaila
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 172:65-70. 2010
    We developed and evaluated two nested polymerase chain reaction (nPCR) assays for the diagnosis of Babesia bovis infection in cattle based on two membrane protein genes from B. bovis, BBOV_IV005650 (BV5650) and BBO_IV008970 (BV8970)...
  30. ncbi Seroprevalence of Babesia bovis and Babesia bigemina in cattle in the Soutpansberg region, Limpopo Province, South Africa, associated with changes in vector-tick populations
    M H Tønnesen
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    J S Afr Vet Assoc 77:61-5. 2006
    ..farms in Limpopo Province, South Africa, during 1999 and 2000 to determine the seroprevalence of antibodies to Babesia bovis and Babesia bigemina. Cattle seropositive for B...
  31. ncbi Babesia bovis: effects of cysteine protease inhibitors on in vitro growth
    Kazuhiro Okubo
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Exp Parasitol 117:214-7. 2007
    ..four kinds of cysteine protease inhibitors (E64, E64d, leupeptin, and ALLN) on the in vitro asexual growth of Babesia bovis. Of these, only the lipophilic inhibitors, E64d and ALLN, were found to effectively inhibit the growth of B...
  32. pmc Competitive enzyme-linked immunosorbent assay based on a rhoptry-associated protein 1 epitope specifically identifies Babesia bovis-infected cattle
    Will L Goff
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Diagn Lab Immunol 10:38-43. 2003
    ..tandemly repeated B-cell epitope within the C terminus of the rhoptry-associated protein 1 of the hemoparasite Babesia bovis was cloned and expressed as a histidine-tagged thioredoxin fusion peptide and used as antigen in a cELISA...
  33. ncbi Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis
    Sabine Bork
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Mol Biochem Parasitol 136:165-72. 2004
    In this study, we characterized a novel Babesia bovis cDNA clone obtained by immunoscreening the cDNA expression phage library with B. bovis-infected bovine serum...
  34. ncbi Transient transfection of purified Babesia bovis merozoites
    Carlos E Suarez
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Exp Parasitol 118:498-504. 2008
    Transient transfection of intraerythrocytic Babesia bovis parasites has been previously reported. In this study, we describe the development and optimization of methods for transfection of purified B...
  35. ncbi A quantitative PCR assay for the detection and quantification of Babesia bovis and B. bigemina
    A Buling
    Microbiology and Parasitology Department, Faculty of Pharmacy, University of Alcala, 28871 Alcala de Henares, Spain
    Vet Parasitol 147:16-25. 2007
    The haemoparasites Babesia bovis and Babesia bigemina affect cattle over vast areas of the tropics and temperate parts of the world...
  36. ncbi Development of a rapid immunochromatographic test for simultaneous serodiagnosis of bovine babesioses caused by Babesia bovis and Babesia bigemina
    Chul Min Kim
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido, Japan
    Am J Trop Med Hyg 78:117-21. 2008
    ..alternative, a rapid immunochromatographic test (BoiICT) was constructed for the simultaneous detection of Babesia bovis- and Babesia bigemina-specific antibodies using B. bovis recombinant merozoite surface antigen-2c and B...
  37. ncbi The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type-1 cytokine induction and NK-like cells in the spleen
    W L Goff
    Animal Disease Research Unit, USDA ARS, Pullman, WA 99164 6630, USA
    Parasite Immunol 25:185-8. 2003
    The innate immune response to Babesia bovis infection in cattle is age-related, spleen-dependent and, in stabilate inoculated calves, has type-1 characteristics, including the early induction of IL-12 and IFN-gamma...
  38. pmc Evaluation of an enzyme-linked immunosorbent assay with recombinant rhoptry-associated protein 1 antigen against Babesia bovis for the detection of specific antibodies in cattle
    Suthisak Boonchit
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    J Clin Microbiol 40:3771-5. 2002
    The gene encoding Babesia bovis rhoptry-associated protein 1 (RAP-1) was used to develop an enzyme-linked immunosorbent assay (ELISA) to measure specific antibodies against B. bovis. The B...
  39. ncbi Real-time polymerase chain reaction based on msa2c gene for detection of Babesia bovis
    Carlos A N Ramos
    Embrapa Gado de Corte, BR 262km 4 CP 154, 79002 970 Campo Grande, MS, Brazil
    Vet Parasitol 176:79-83. 2011
    ..reaction (q-PCR) based on the msa2c gene and standardized with Platinum SYBR Green/ROX for the detection of Babesia bovis in cattle. The msa2c q-PCR amplified a DNA fragment with average dissociation temperature of 77.41°C (± 0...
  40. ncbi In vitro responsiveness of Babesia bovis to imidocarb dipropionate and the selection of a drug-adapted line
    R I Rodriguez
    Department of Veterinary Parasitology, Liverpool School of Tropical Medicine, UK
    Vet Parasitol 62:35-41. 1996
    A South African stock of Babesia bovis was successfully resuscitated from liquid nitrogen, and cultured in microaerophilous stationary phase. The in vitro susceptibility of the B...
  41. ncbi Stable expression of green fluorescent protein and targeted disruption of thioredoxin peroxidase-1 gene in Babesia bovis with the WR99210/dhfr selection system
    Masahito Asada
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro 080 8555, Japan
    Mol Biochem Parasitol 181:162-70. 2012
    We have achieved stable expression of green fluorescent protein (GFP) in Babesia bovis by using the WR99210/human dihydrofolate reductase (DHFR) gene selection system...
  42. ncbi Molecular and serologic evidence for Babesia bovis-like parasites in white-tailed deer (Odocoileus virginianus) in south Texas
    Christina M Ramos
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Parasitol 172:214-20. 2010
    The current study was undertaken to determine if white-tailed deer in south Texas harbor Babesia bovis, a causative agent of bovine babesiosis...
  43. ncbi Dynamics of bovine spleen cell populations during the acute response to Babesia bovis infection: an immunohistological study
    D A Schneider
    Animal Disease Research Unit, USDA ARS, Washington State University, Pullman, Washington 99164 6630, USA
    Parasite Immunol 33:34-44. 2011
    ..was used to monitor the splenic distribution of defined cells during the acute response of naïve calves to Babesia bovis infection...
  44. ncbi Epizootiology of Babesia bovis and Babesia bigemina in free-ranging white-tailed deer in northeastern Mexico
    Antonio Cantu-C
    INIFAP CIRNE Campo Experimental Aldama, Tamaulipas, Km 18 5 Carretera Est Manuel Aldama, Aldama, Tamaulipas, C P 89679, Mexico
    J Parasitol 95:536-42. 2009
    ..The objectives of this study were to determine the frequency of Babesia bovis and Babesia bigemina and the prevalence of antibodies to them and identify possible risk factors for bovine ..
  45. ncbi Prospects for recombinant vaccines against Babesia bovis and related parasites
    W C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Parasite Immunol 28:315-27. 2006
    ..Development of successful non-living recombinant vaccines will depend on increased understanding of protective immune mechanisms and availability of parasite genomes...
  46. pmc Erythrocyte invasion by Babesia bovis merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 1
    Fasila R Gaffar
    Department of Infectious Diseases and Immunology, Utrecht University, 3508 TD, Utrecht, The Netherlands
    Infect Immun 72:2947-55. 2004
    ..Here we describe cloning and characterization of a Babesia bovis AMA-1 homologue designated BbAMA-1. The overall level of similarity of BbAMA-1 to P...
  47. pmc Cellular localization of Babesia bovis merozoite rhoptry-associated protein 1 and its erythrocyte-binding activity
    Naoaki Yokoyama
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Infect Immun 70:5822-6. 2002
    The cellular localization of Babesia bovis rhoptry-associated protein 1 (RAP-1) and its erythrocyte-binding affinity were examined with anti-RAP-1 antibodies...
  48. ncbi Antigenic variation in Babesia bovis: how similar is it to that in Plasmodium falciparum?
    D R Allred
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32611 0880, USA
    Ann Trop Med Parasitol 92:461-72. 1998
    Despite significant differences in some aspects of their life-cycles, the Apicomplexan parasites Babesia bovis and Plasmodium falciparum share many parallels...
  49. ncbi Attenuated vaccines for tropical theileriosis, babesiosis and heartwater: the continuing necessity
    Varda Shkap
    Division of Parasitology, Kimron Veterinary Institute, Bet Dagan, Israel
    Trends Parasitol 23:420-6. 2007
    ..As a result, there is a continuing necessity to use available live vaccines in tick and tick-borne disease-control strategies adapted to conditions prevailing in many parts of the world...
  50. ncbi Lipids from attenuated and virulent Babesia bovis strains induce differential TLR2-mediated macrophage activation
    G Gimenez
    Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Mol Immunol 47:747-55. 2010
    b>Babesia bovis is an intraerythrocytic apicomplexan protozoa of cattle that causes an acute infection with parasite persistence...
  51. pmc Identification, expression and characterisation of a Babesia bovis hexose transporter
    Elvira T Derbyshire
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Mol Biochem Parasitol 161:124-9. 2008
    ..Here, two predicted hexose transporters (BboHT1 and 2) have been identified within the Babesia bovis genome...
  52. ncbi Identity of the causal agents of human babesiosis in Europe
    Jeremy S Gray
    Department of Environmental Resource Management, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    Int J Med Microbiol 296:131-6. 2006
    ..Comparative biology should support genetic data in taxonomic studies of both B. divergens and B. microti...
  53. pmc Babesia bovis merozoite surface antigen 1 and rhoptry-associated protein 1 are expressed in sporozoites, and specific antibodies inhibit sporozoite attachment to erythrocytes
    Juan Mosqueda
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:1599-603. 2002
    We examined Babesia bovis sporozoites for the expression of two molecules, merozoite surface antigen 1 (MSA-1) and rhoptry-associated protein 1 (RAP-1), that are postulated to be involved in the invasion of host erythrocytes...
  54. ncbi Transfection systems for Babesia bovis: a review of methods for the transient and stable expression of exogenous genes
    Carlos E Suarez
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Vet Parasitol 167:205-15. 2010
    With the recently sequenced Babesia bovis genome, a large pool of genes with unknown function was identified...
  55. ncbi Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus
    C E Suarez
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Mol Biochem Parasitol 93:215-24. 1998
    ..bigemina versus B. bovis are reflected in the marked structural and antigenic polymorphism in the B. bigemina RAP-1 molecules as compared with the essentially monomorphic RAP-1 in B. bovis...
  56. ncbi Characterisation of erythrocyte invasion by Babesia bovis merozoites efficiently released from their host cell after high-voltage pulsing
    Frits F J Franssen
    Division of Parasitology and Tropical Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, P O Box 80165, 3508 TD, Utrecht, The Netherlands
    Microbes Infect 5:365-72. 2003
    ..An in vitro assay for erythrocyte invasion by Babesia bovis was established, employing free merozoites obtained after the application of high-voltage to the parasitised ..
  57. pmc Genotypic diversity of merozoite surface antigen 1 of Babesia bovis within an endemic population
    Audrey O T Lau
    Programs in Genomics and Vector borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 172:107-12. 2010
    ..In Babesia bovis, genetic diversity of variable merozoite surface antigen (VMSA) genes has been associated with disease ..
  58. ncbi Age-related innate immune response in calves to Babesia bovis involves IL-12 induction and IL-10 modulation
    W L Goff
    Animal Diseases Research Unit, USDA ARS, Pullman, Washington 99164, USA
    Ann N Y Acad Sci 969:164-8. 2002
    There is a strong innate immunity in calves to infection with Babesia bovis. Interleukin (IL)-12 and IL-10 have been shown in vitro to be important immunoregulatory cytokines...
  59. pmc Babesia bovis merozoite surface antigen 2 proteins are expressed on the merozoite and sporozoite surface, and specific antibodies inhibit attachment and invasion of erythrocytes
    Juan Mosqueda
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:6448-55. 2002
    The Babesia bovis merozoite surface antigen 2 (MSA-2) locus encodes four proteins, MSA-2a(1), -2a(2), -2b, and -2c...
  60. ncbi Immunochemical characterization of in vitro culture-derived antigens of Babesia bovis and Babesia bigemina
    L M Passos
    Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Vet Parasitol 76:239-49. 1998
    Cross-reactivity between Babesia bovis and B. bigemina becomes a problem in discrimination of the two infections in endemic areas where the two species usually occur in association...
  61. ncbi Immune control of Babesia bovis infection
    Wendy C Brown
    Program in Vector borne Disease, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Vet Parasitol 138:75-87. 2006
    b>Babesia bovis causes an acute and often fatal infection in adult cattle, which if resolved, leads to a state of persistent infection in otherwise clinically healthy cattle...
  62. ncbi A novel 78-kDa fatty acyl-CoA synthetase (ACS1) of Babesia bovis stimulates memory CD4+ T lymphocyte responses in B. bovis-immune cattle
    Junzo Norimine
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 147:20-9. 2006
    Antigen-specific CD4+ T lymphocyte responses contribute to protective immunity against Babesia bovis, however the antigens that induce these responses remain largely unknown. A proteomic approach was used to identify novel B...
  63. ncbi Bovine NK cells acquire cytotoxic activity and produce IFN-gamma after stimulation by Mycobacterium bovis BCG- or Babesia bovis-exposed splenic dendritic cells
    R G Bastos
    Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
    Vet Immunol Immunopathol 124:302-12. 2008
    ..the activation of bovine NK cells by CD13(+) splenic DC stimulated with either Mycobacterium bovis BCG or Babesia bovis merozoites...
  64. ncbi Antigenic variation by protozoan parasites: insights from Babesia bovis
    Ron Dzikowski
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Mol Microbiol 59:364-6. 2006
    ..b>Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation ..
  65. pmc Merozoite surface antigen 2 proteins of Babesia bovis vaccine breakthrough isolates contain a unique hypervariable region composed of degenerate repeats
    Shawn J Berens
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 73:7180-9. 2005
    The merozoite surface antigen 2 (MSA-2) proteins of Babesia bovis are members of the variable merozoite surface antigen (VMSA) family that have been implicated in erythrocyte invasion and are important targets for antibody-mediated ..
  66. pmc Sequence variation and immunologic cross-reactivity among Babesia bovis merozoite surface antigen 1 proteins from vaccine strains and vaccine breakthrough isolates
    Tanya LeRoith
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 73:5388-94. 2005
    The Babesia bovis merozoite surface antigen 1 (MSA-1) is an immunodominant membrane glycoprotein that is the target of invasion-blocking antibodies...
  67. ncbi Immunologic and molecular identification of Babesia bovis and Babesia bigemina in free-ranging white-tailed deer in northern Mexico
    Antonio Cantu
    Texas A and M University Kinsgsville, Caesar Kleberg Wildlife Research Institute, MSC 218, 700 University Blvd, Kingsville, Texas 78363, USA
    J Wildl Dis 43:504-7. 2007
    ..These ticks have a wide host range, and both transmit Babesia bovis and Babesia bigemina, the agents responsible for bovine babesiosis...
  68. ncbi Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte cultures
    Will L Goff
    Animal Disease Research Unit, USDA ARS, Pullman, Washington, USA
    Parasite Immunol 28:221-8. 2006
    ..Young calves demonstrate a strong spleen-dependent innate response to an initial infection with Babesia bovis involving the type-1 regulating cytokines IL-12 and IFN-gamma...
  69. pmc Validation of a competitive enzyme-linked immunosorbent assay for detection of antibodies against Babesia bovis
    Will L Goff
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Vaccine Immunol 13:1212-6. 2006
    ..conserved, and tandemly repeated B-cell epitope within the C terminus of rhoptry-associated protein 1 of Babesia bovis was refined and validated for use internationally...
  70. ncbi Proteomic profiling of Rhipicephalus (Boophilus) microplus midgut responses to infection with Babesia bovis
    Anna Rachinsky
    Knipling Bushland US Livestock Insects Research Laboratory, U S Department of Agriculture Agricultural Research Service, 2700 Fredericksburg Road, Kerrville, TX 78028, USA
    Vet Parasitol 152:294-313. 2008
    Differences in protein expression in midgut tissue of uninfected and Babesia bovis-infected southern cattle ticks, Rhipicephalus (Boophilus) microplus, were investigated in an effort to establish a proteome database containing proteins ..
  71. pmc Coinfection with antigenically and genetically distinct virulent strains of Babesia bovis is maintained through all phases of the parasite life cycle
    Shawn J Berens
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 75:5769-76. 2007
    Antigenic polymorphism is a defining characteristic of the Babesia bovis variable merozoite surface antigen (VMSA) family. Sequence analysis strongly suggests that recombination between virulent strains contributes to VMSA diversity...
  72. ncbi Phylogenetic analysis of Mexican Babesia bovis isolates using msa and ssrRNA gene sequences
    Alma D Genis
    Posgrado en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico, Mexico City, Mexico
    Ann N Y Acad Sci 1149:121-5. 2008
    Variable merozoite surface antigens of Babesia bovis are exposed glycoproteins having a role in erythrocyte invasion. Members of this gene family include msa-1 and msa-2 (msa-2c, msa-2a(1), msa-2a(2), and msa-2b)...
  73. ncbi Differential response of splenic monocytes and DC from cattle to microbial stimulation with Mycobacterium bovis BCG and Babesia bovis merozoites
    R G Bastos
    Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
    Vet Immunol Immunopathol 115:334-45. 2007
    ..nitric oxide and had a different pattern of cytokine mRNA when stimulated with Mycobacterium bovis BCG or Babesia bovis merozoites...
  74. pmc Transovarial transmission efficiency of Babesia bovis tick stages acquired by Rhipicephalus (Boophilus) microplus during acute infection
    Jeanne M Howell
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Clin Microbiol 45:426-31. 2007
    The protozoan parasite Babesia bovis, a reemerging threat to U.S. cattle, is acquired by adult female ticks of the subgenus Boophilus and is transovarially transmitted as the kinete stage to developing larval offspring...
  75. ncbi Search for Babesia bovis vaccine candidates
    M Florin-Christensen
    Institute of Pathobiology, CICVyA, INTA Castelar, Buenos Aires, Argentina
    Parassitologia 49:9-12. 2007
    b>Babesia bovis is a tick-borne apicomplexan pathogen that remains an important constrain for the development of cattle industries worldwide...
  76. ncbi Differential Bos taurus cattle response to Babesia bovis infection
    Magda Vieira Benavides
    South Embrapa Cattle and Sheep Research Centre, BR 153 km 595 P O Box 242, Bage, RS 96401 970, Brazil
    Vet Parasitol 150:54-64. 2007
    ..alternative to help in babesiosis control would be the identification of genetically resistant cattle to Babesia bovis infection. The objective of this work was to phenotype cattle based on primary response against B...
  77. ncbi Cellular adhesive phenomena in apicomplexan parasites of red blood cells
    Brian M Cooke
    Department of Microbiology, Monash University, VIC 3800, Australia
    Vet Parasitol 132:273-95. 2005
    ..that culminate in accumulation of parasitised red blood cells in the microvasculature of cattle infected with Babesia bovis (babesiosis) and humans infected with Plasmodium falciparum (falciparum malaria) is particularly instructive ..
  78. ncbi Genotypic diversity in field isolates of Babesia bovis from cattle with babesiosis after vaccination
    A E Lew
    Animal Research Institute, Queensland Department of Primary Industries, Moorooka
    Aust Vet J 75:575-8. 1997
    To determine whether particular genotypes of Babesia bovis were common to field isolates obtained from cattle properties in Queensland where the B bovis vaccine had apparently failed.
  79. ncbi Babesia bovis merozoites invade human, ovine, equine, porcine and caprine erythrocytes by a sialic acid-dependent mechanism followed by developmental arrest after a single round of cell fission
    Fasila R Gaffar
    Division of Parasitology and Tropical Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, P O Box 80165, 3508 TD Utrecht, The Netherlands
    Int J Parasitol 33:1595-603. 2003
    b>Babesia bovis infections have only been observed in bovine species in contrast to Babesia divergens that also can infect humans, sheep and rodents...
  80. ncbi Antigenic variation and cytoadhesion in Babesia bovis and Plasmodium falciparum: different logics achieve the same goal
    David R Allred
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611 0880, USA
    Mol Biochem Parasitol 134:27-35. 2004
    b>Babesia bovis is a protozoal hemoparasite of cattle which behaves in certain crucial respects like Plasmodium falciparum, despite being phylogenetically distant and having many differences in its life cycle...
  81. ncbi Babesia bovis merozoite surface protein-2c (MSA-2c) contains highly immunogenic, conserved B-cell epitopes that elicit neutralization-sensitive antibodies in cattle
    S E Wilkowsky
    CICVyA, INTA Castelar, Los Reseros y Las Cabanas, 1712, Castelar, Argentina
    Mol Biochem Parasitol 127:133-41. 2003
    The search for vaccine candidates against bovine babesiosis caused by Babesia bovis is greatly focused on the identification of merozoite surface-exposed antigens that are widely conserved, functionally relevant and immunodominant in ..
  82. ncbi A Babesia bovis merozoite protein with a domain architecture highly similar to the thrombospondin-related anonymous protein (TRAP) present in Plasmodium sporozoites
    Fasila R Gaffar
    Department of Infectious Diseases and Immunology, Division of Parasitology and Tropical Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Biochem Parasitol 136:25-34. 2004
    ..Here, we report the cloning and characterization of a Babesia bovis TRAP homologue (BbTRAP)...
  83. ncbi IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites
    W L Goff
    Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
    Vet Immunol Immunopathol 84:237-51. 2002
    The requirement for IFN-gamma and/or TNF-alpha as co-stimulants with Babesia bovis merozoites for nitric oxide (NO) production was examined, as well as the regulatory role of IL-4 and IL-10. Purified B...
  84. ncbi Molecular approaches to elucidating innate and acquired immune responses to Babesia bovis, a protozoan parasite that causes persistent infection
    W C Brown
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Vet Parasitol 101:233-48. 2001
    ..of the molecular basis for innate and acquired immunity against the hemoprotozoan parasite of cattle, Babesia bovis. Knowledge of mechanisms used by the parasite to survive within infected cattle from acute to persistent ..
  85. ncbi The age-related immunity in cattle to Babesia bovis infection involves the rapid induction of interleukin-12, interferon-gamma and inducible nitric oxide synthase mRNA expression in the spleen
    W L Goff
    Animal Disease Research Unit, USDA ARS, Washington State University, Pullman, Washington, WA 99164, USA
    Parasite Immunol 23:463-71. 2001
    Young calves possess a strong innate immunity against Babesia bovis infection that lasts for approximately 6 months after birth and is abrogated with the removal of the spleen...
  86. ncbi Babesiosis (Babesia bovis) stability in unstable environments
    R D Smith
    College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Ann N Y Acad Sci 916:510-20. 2000
    ..control strategies (none, threshold, and strategic) on enzootic stability and the likelihood of babesiosis (Babesia bovis) outbreaks was studied using a spreadsheet age-class computer simulation model...
  87. pmc Characterization of allelic variation in the Babesia bovis merozoite surface antigen 1 (MSA-1) locus and identification of a cross-reactive inhibition-sensitive MSA-1 epitope
    C E Suarez
    Program in Vector Borne Diseases, Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Washington 99164, USA
    Infect Immun 68:6865-70. 2000
    The Babesia bovis merozoite surface antigen 1 (MSA-1), a member of the variable merozoite surface antigen (VMSA) family, is an immunodominant glycoprotein which elicits antibodies that inhibit erythrocyte invasion...
  88. pmc A Babesia bovis 225-kilodalton spherical-body protein: localization to the cytoplasmic face of infected erythrocytes after merozoite invasion
    S C Dowling
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 64:2618-26. 1996
    A 225-kDa Babesia bovis protein occurs on the cytoplasmic side of infected-erythrocyte membranes. Here it is demonstrated that the 225-kDa protein localizes to spherical-body organelles of merozoites...
  89. pmc DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells
    W C Brown
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 66:5423-32. 1998
    ..that the mitogenic property of protozoal antigen preparations is in part attributable to parasite DNA and that Babesia bovis DNA is directly mitogenic for bovine B cells. DNase treatment of B. bovis extracts abrogated B...
  90. ncbi Phosphatidylcholine formation is the predominant lipid biosynthetic event in the hemoparasite Babesia bovis
    J Florin-Christensen
    Department of Veterinary Microbiology and Pathology, Washington State University WSU, Pullman 99164 7040, USA
    Mol Biochem Parasitol 106:147-56. 2000
    ..We found that erythrocytes infected with Babesia bovis (i-RBC) accumulate lipids and show striking increases in phosphatidylcholine, phosphatidic acid, ..
  91. ncbi Can Babesia infections be used as a model for cerebral malaria?
    T P Schetters
    Intervet International B V, Parasitology R and D Department, PO Box 31, 5830 AA Boxmeer, The Netherlands
    Parasitol Today 15:492-7. 1999
    ..Finally, they discuss the use of animal model systems for specific aspects of the pathological picture...
  92. pmc Conservation of Babesia bovis small heat shock protein (Hsp20) among strains and definition of T helper cell epitopes recognized by cattle with diverse major histocompatibility complex class II haplotypes
    Junzo Norimine
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 72:1096-106. 2004
    b>Babesia bovis small heat shock protein (Hsp20) is recognized by CD4+ T lymphocytes from cattle that have recovered from infection and are immune to challenge...
  93. ncbi Expressed sequence tag (EST) analysis of the erythrocytic stages of Babesia bovis
    Erik de Vries
    Division of Infection Biology, Department of Infectious Diseases and Immunology, Utrecht University, P O Box 80165, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 138:61-74. 2006
    ..Here we analysed approximately 13,000 ESTs derived from the erythrocytic stage of the apicomplexan parasite Babesia bovis. The ESTs were clustered in order to obtain information on the expression level of a gene and to increase ..
  94. ncbi Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro
    K Nakamura
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Parasitology 134:1347-53. 2007
    ..describes the inhibitory effect of purine derivatives known to be CDK inhibitors on the asexual growth of Babesia bovis. The 4 compounds, roscovitine, purvalanol A, CGP74514A, and CDK2 Inhibitor II, showed significantly ..
  95. ncbi Development of two immunochromatographic tests for the serodiagnosis of bovine babesiosis
    Chulmin Kim
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 148:137-43. 2007
    ..membrane-based immunoassays for the convenient and rapid serodiagnosis of bovine babesiosis caused by Babesia bovis (BoICT) and Babesia bigemina (BiICT)...
  96. ncbi Comparison of duplex PCR and microscopic techniques for the identification of Babesia bigemina and Babesia bovis in engorged female ticks of Boophilus microplus
    M G Quintão-Silva
    Unifenas, Departmento de Parasitologia, Belo Horizonte MG, Brazil
    Zoonoses Public Health 54:147-51. 2007
    ..and traditional microscopic examination of haemolymph smears were used to detect Babesia bigemina and/or Babesia bovis infection in engorged female ticks of Boophilus microplus recovered from calves raised in an endemic area of ..
  97. ncbi PCR-based detection of the transovarial transmission of Uruguayan Babesia bovis and Babesia bigemina vaccine strains
    V Gayo
    DILAVE, Ministry of Agriculture, Livestock and Fisheries, Montevideo, Uruguay
    Onderstepoort J Vet Res 70:197-204. 2003
    ..It is feared that the attenuated Babesia bovis and Babesia bigemina vaccine strains may be transmitted by the local tick vector Boophilus microplus, and that ..
  98. ncbi Epidemiological studies on tick-borne diseases of cattle in Central Equatoria State, Southern Sudan
    D A Salih
    Central Veterinary Research Laboratories, Al Amarat, PO Box 8067, Khartoum, Sudan
    Parasitol Res 101:1035-44. 2007
    ..3%), Theileria taurotragi (2.7%), Theileria buffeli (0.5%), Theileria annulata (0.2%), Babesia bovis (1.7%), and Babesia bigemina (0.3%). Mixed infections were detected in 406 samples (67...
  99. pmc Stimulation of T-helper cell gamma interferon and immunoglobulin G responses specific for Babesia bovis rhoptry-associated protein 1 (RAP-1) or a RAP-1 protein lacking the carboxy-terminal repeat region is insufficient to provide protective immunity again
    Junzo Norimine
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 71:5021-32. 2003
    Rhoptry-associated protein 1 (RAP-1) is a targeted vaccine antigen for Babesia bovis and Babesia bigemina infections of cattle. The 60-kDa B...
  100. pmc Identification of newly isolated Babesia parasites from cattle in Korea by using the Bo-RBC-SCID mice
    Shin Hyeong Cho
    Department of Medical Zoology, National Institute of Health, Seoul, 122 701 Korea
    Korean J Parasitol 40:33-40. 2002
    ..var. Haemaphysalis longicornis was the most probable tick species that transmitted the parasite...
  101. ncbi Epidemiology of bovine tick-borne diseases in southern Italy
    Giuseppe Cringoli
    Dipartimento di Patologia e Sanita Animale, Universita degli Studi di Napoli Federico II, Italy
    Vet Res 33:421-8. 2002
    ..Serum samples were tested for antibodies of Bahesia bigemina, Babesia bovis and Anaplasma marginale with an ELISA technique. Eight farms (9.8%) out of the 81 examined were positive for B...

Research Grants12

  1. The Role of Babesia bovis MSA-1 in Erythrocyte Invasion
    Tanya LeRoith; Fiscal Year: 2004
    ..I propose to use Babesia bovis infection of bovine erythrocytes as a model to investigate the function of merozoite surface proteins in ..
  2. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2011
    ..by applicant): This proposal will investigate virulence mechanisms of cytoadherence/sequestration using Babesia bovis as a natural host model system. Virulent B...
  3. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2013
    ..by applicant): This proposal will investigate virulence mechanisms of cytoadherence/sequestration using Babesia bovis as a natural host model system. Virulent B...
  4. Mechanisms controlling babesial antigenic variation
    DAVID ALLRED; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Babesia bovis is a protozoan intraerythrocytic parasite that establishes persistent infections of extremely long duration...
  5. IDENTIFICATION OF BABESIA IMMUNOGENS WITH TH CEL
    Wendy Brown; Fiscal Year: 2000
    ..The pathology of-Babesia bovis infection in cattle is very similar to that caused by Plasmodium falciparum infections in humans, and is ..
  6. EPITOPE DISCOVERY--NEW ROUTE TO VACCINES
    George Smith; Fiscal Year: 2002
    ..Using a second model system--the cattle disease caused by the tick-borne, malaria-like parasite Babesia bovis--we will show how antigenic peptides can be screened in vitro for the likelihood of protective value...
  7. Genetic Characterization and Biology of Plague from Multiple Foci
    David Wagner; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  8. Generation of babesial surface protein diversity
    SHAWN BERENS; Fiscal Year: 2006
    ..The hemoparasite model we will use for this research is infection of cattle with Babesia bovis. For B...
  9. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  10. Comparison of US and European Babesia divergens Isolates
    Patricia Holman; Fiscal Year: 2004
    ..The molecular aspects may provide information that will be useful in future efforts to devise diagnostic tests. ..