babesia microti

Summary

Summary: A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.

Top Publications

  1. ncbi Serological diagnosis of human babesiosis by IgG enzyme-linked immunosorbent assay
    Chien Chang Loa
    Department of Research and Development, Medical Diagnostic Laboratories, L L C, Mount Laurel, NJ 08054, USA
    Curr Microbiol 49:385-9. 2004
  2. pmc Transfusion-transmitted Babesia spp.: bull's-eye on Babesia microti
    David A Leiby
    Transmissible Diseases Department, American Red Cross Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Clin Microbiol Rev 24:14-28. 2011
  3. pmc Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Appl Environ Microbiol 74:7118-25. 2008
  4. ncbi Babesiosis in humans: a treatment review
    Louis M Weiss
    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, New York, 10461, USA
    Expert Opin Pharmacother 3:1109-15. 2002
  5. ncbi Transfusion-associated babesiosis in the United States: a description of cases
    Barbara L Herwaldt
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 155:509-19. 2011
  6. ncbi The molecular evidence of Babesia microti infection in small mammals collected in Slovenia
    D Duh
    Institute of Microbiology and Immunology, Medical Faculty, 1000 Ljubljana, Slovenia
    Parasitology 126:113-7. 2003
  7. ncbi Babesia microti-group parasites compared phylogenetically by complete sequencing of the CCTeta gene in 36 isolates
    Rui Nakajima
    School of Veterinary Medicine, Rakuno Gakuen University, 582 1 Bunkyodai Midorimachi, Ebetsu, Japan
    J Vet Med Sci 71:55-68. 2009
  8. pmc Correlation between tick density and pathogen endemicity, New Hampshire
    Seth T Walk
    University of Massachusetts, Amherst, Massachusetts, USA
    Emerg Infect Dis 15:585-7. 2009
  9. ncbi The common shrew (Sorex araneus): a neglected host of tick-borne infections?
    Kevin J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Vector Borne Zoonotic Dis 11:947-53. 2011
  10. ncbi Molecular survey of Babesia microti in wild rodents in central Croatia
    Relja Beck
    Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Croatia
    Vector Borne Zoonotic Dis 11:81-3. 2011

Research Grants

Detail Information

Publications191 found, 100 shown here

  1. ncbi Serological diagnosis of human babesiosis by IgG enzyme-linked immunosorbent assay
    Chien Chang Loa
    Department of Research and Development, Medical Diagnostic Laboratories, L L C, Mount Laurel, NJ 08054, USA
    Curr Microbiol 49:385-9. 2004
    An enzyme-linked immunosorbent assay (ELISA) for the detection of IgG antibodies to Babesia microti antigen was developed. B. microti antigens were harvested from experimentally infected hamster blood and used as a coating antigen...
  2. pmc Transfusion-transmitted Babesia spp.: bull's-eye on Babesia microti
    David A Leiby
    Transmissible Diseases Department, American Red Cross Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Clin Microbiol Rev 24:14-28. 2011
    ..or types of Babesia have been described in the literature as causing infection in humans, the rodent parasite Babesia microti has emerged as the focal point of human disease, especially in the United States. Not only has B...
  3. pmc Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Appl Environ Microbiol 74:7118-25. 2008
    ..ricinus and I. trianguliceps in the transmission of Anaplasma phagocytophilum and Babesia microti among United Kingdom field voles (Microtus agrestis), which serve as reservoir hosts for both pathogens...
  4. ncbi Babesiosis in humans: a treatment review
    Louis M Weiss
    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, New York, 10461, USA
    Expert Opin Pharmacother 3:1109-15. 2002
    Human infections with Babesia species, in particular Babesia microti, are tick-borne illnesses that are being recognised with increased frequency...
  5. ncbi Transfusion-associated babesiosis in the United States: a description of cases
    Barbara L Herwaldt
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 155:509-19. 2011
    ..Tickborne transmission of Babesia microti mainly occurs in 7 states in the Northeast and the upper Midwest of the United States...
  6. ncbi The molecular evidence of Babesia microti infection in small mammals collected in Slovenia
    D Duh
    Institute of Microbiology and Immunology, Medical Faculty, 1000 Ljubljana, Slovenia
    Parasitology 126:113-7. 2003
    In Europe, the zoonotic cycle of Babesia microti has not been determined so far. Recently, B. microti was detected in Ixodes ricinus ticks in Slovenia by using molecular methods. In order to investigate the mammalian hosts of B...
  7. ncbi Babesia microti-group parasites compared phylogenetically by complete sequencing of the CCTeta gene in 36 isolates
    Rui Nakajima
    School of Veterinary Medicine, Rakuno Gakuen University, 582 1 Bunkyodai Midorimachi, Ebetsu, Japan
    J Vet Med Sci 71:55-68. 2009
    b>Babesia microti, the erythroparasitic cause of human babesiosis, has long been taken to be a single species because classification by parasite morphology and host spectrum blurred distinctions between the parasites...
  8. pmc Correlation between tick density and pathogen endemicity, New Hampshire
    Seth T Walk
    University of Massachusetts, Amherst, Massachusetts, USA
    Emerg Infect Dis 15:585-7. 2009
    ..Pathogens were more prevalent in areas of high tick density, suggesting a correlation between tick establishment and pathogen endemicity. Infection rates in ticks correlated with disease frequency in humans...
  9. ncbi The common shrew (Sorex araneus): a neglected host of tick-borne infections?
    Kevin J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Vector Borne Zoonotic Dis 11:947-53. 2011
    ..7%) showed evidence of infection with Anaplasma phagocytophilum and 196 (30.3%) with Babesia microti. By comparison, of 1505 blood samples from field voles, 96 (6.4%) were positive for A...
  10. ncbi Molecular survey of Babesia microti in wild rodents in central Croatia
    Relja Beck
    Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Croatia
    Vector Borne Zoonotic Dis 11:81-3. 2011
    ..Recently, the first case of human infection with Babesia microti was confirmed in Germany, implicating the presence of zoonotic isolates...
  11. pmc Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti
    Emmanuel Cornillot
    Laboratoire de Biologie Cellulaire et Moléculaire LBCM EA4558, UFR Pharmacie, Universite Montpellier 1, 15, Av Charles Flahault, 34093 Montpellier Cedex 5, France
    Nucleic Acids Res 40:9102-14. 2012
    We have sequenced the genome of the emerging human pathogen Babesia microti and compared it with that of other protozoa. B...
  12. ncbi Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests
    Joanna Stanczak
    Medical University of Gdansk, Interfaculty Institute of Maritime and Tropical Medicine, 9B Powstania Styczniowego str, 81 519 Gdynia, Poland
    Ann Agric Environ Med 11:109-14. 2004
    ..human anaplasmosis (HA) and babesiosis: Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti, respectively...
  13. pmc Assessment of polymicrobial infections in ticks in New York state
    Rafal Tokarz
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Vector Borne Zoonotic Dis 10:217-21. 2010
    ..We determined the prevalence of polymicrobial infection with Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and Powassan virus in 286 adult ticks from the two counties in New York State where Lyme ..
  14. ncbi Molecular evidence of coinfection of Borrelia burgdorferi sensu lato, human granulocytic ehrlichiosis agent, and Babesia microti in ticks from northwestern Poland
    B Skotarczak
    Faculty of Biology, Department of Genetics, University of Szczecin, Piastow 40B, 71 065 Szczecin, Poland
    J Parasitol 89:194-6. 2003
    ..l.), human granulocytic ehrlichiosis (HGE) agent, and Babesia microti. Of the 533 processed ticks, 16.7% were positive for B. burgdorferi s. l., 13.3% for B. microti, and 4...
  15. ncbi Babesia microti-like infections are prevalent in North American foxes
    Adam J Birkenheuer
    Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA
    Vet Parasitol 172:179-82. 2010
    b>Babesia microti-like organisms have recently been identified as a cause of hemolytic anemia and azotemia in European dogs. A genetically and morphologically similar B...
  16. ncbi Zoonotic reservoir of Babesia microti in Poland
    Grzegorz Karbowiak
    W Stefański Institute of Parasitology of Polish Academy of Sciences, 00 818 Warsaw, Poland
    Pol J Microbiol 53:61-5. 2004
    ..evidence of human babesiosis suggests that the majority of cases are involved by Babesia divergens and Babesia microti piroplasms. As zoonotic reservoir of B. microti serve small mammals--insectivores and rodents...
  17. ncbi Preventing transfusion-transmitted babesiosis: preliminary experience of the first laboratory-based blood donor screening program
    Carolyn Young
    Department of Administration and Laboratory Department, Rhode Island Blood Center, RI, USA
    Transfusion 52:1523-9. 2012
    ..We developed and implemented the first laboratory-based blood donor screening program for Babesia microti to help reduce and prevent transfusion-transmitted babesiosis (TTB) and report results for the initial year.
  18. ncbi Babesia microti in rodents and raccoons from northeast Florida
    Kerry Clark
    Department of Public Health, University of North Florida, 1 UNF Drive, Jacksonville, Florida 32224, USA
    J Parasitol 98:1117-21. 2012
    Human babesiosis in the United States is caused most commonly by the intraerythrocytic protozoan parasite, Babesia microti ...
  19. ncbi Epizootiologic survey for Babesia microti among small wild mammals in northeastern Eurasia and a geographic diversity in the beta-tubulin gene sequences
    Aya Zamoto
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    J Vet Med Sci 66:785-92. 2004
    We previously reported that small wild rodents in Japan harbor two types of novel Babesia microti-like parasites (designated as Hobetsu and Kobe types), but not the type commonly found in the northeastern United States (U.S...
  20. ncbi Long term monitoring of Babesia microti infection in BALB/c mice using nested PCR
    Renata Welc-Faleciak
    Department of Parasitology, Institute of Zoology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Ann Agric Environ Med 14:287-90. 2007
    ..microti in the blood of rodent hosts, and could therefore be a tool for environmental monitoring of naturally infected rodents which are the predominant source of infection for tick vectors...
  21. ncbi Serological survey in persons occupationally exposed to tick-borne pathogens in cases of co-infections with Borrelia burgdorferi, Anaplasma phagocytophilum, Bartonella spp. and Babesia microti
    Jolanta Chmielewska-Badora
    Department of Allergology and Environmental Hazards, Institute of Rural Health, Lublin, Poland
    Ann Agric Environ Med 19:271-4. 2012
    ..burgdorferi, as anti-B. microti, A. phagocytophilum and Bartonella spp. antibodies are not more commonly prevalent in persons with occupational risk of tick bites than in healthy volunteers...
  22. ncbi Babesia microti infection in Europe
    Laurence Meer-Scherrer
    Medical Diagnostic Laboratories, Mt Laurel, NJ, USA
    Curr Microbiol 48:435-7. 2004
    ..bovis. Although Babesia microti has been detected in ticks from Switzerland, few if any cases of babesiosis have been caused by B. microti...
  23. ncbi Antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in white-footed mice
    Louis A Magnarelli
    Department of Entomology, The Connecticut Agricultural Experiment Station, PO Box 1106, New Haven, Connecticut 06504, USA
    J Wildl Dis 42:732-8. 2006
    ..period 2001 through 2003 and analyzed for antibodies to Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti. Emphasis was placed on the evaluations of highly specific recombinant VlsE or protein (p) 44 antigens of B...
  24. ncbi Babesia microti-like parasites detected in Eurasian red squirrels (Sciurus vulgaris orientis) in Hokkaido, Japan
    Masayoshi Tsuji
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    J Vet Med Sci 68:643-6. 2006
    ..This is the first report showing molecular evidence for the presence of B. microti-like parasites in Sciuridae...
  25. ncbi Fay and Rausch 1969 revisited: Babesia microti in Alaskan small mammals
    Heidi K Goethert
    Division of Infectious Diseases, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA
    J Parasitol 92:826-31. 2006
    The Holarctic distribution of Babesia microti within small rodents implies an ancient association. A seminal report of piroplasms in Alaskan voles suggested to us the possibility that B...
  26. ncbi First molecular evidence of potentially zoonotic Babesia microti and Babesia sp. EU1 in Ixodes ricinus ticks in Belgium
    Laetitia Lempereur
    Laboratory of Parasitology and Pathology of Parasitic Diseases, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    Vector Borne Zoonotic Dis 11:125-30. 2011
    We report the first molecular evidence of the presence of Babesia sp. EU1 and Babesia microti in Ixodes ricinus ticks in Belgium. A 1-year national survey collected 1005 ticks from cats and dogs...
  27. pmc Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infection
    Young Il Jeong
    Division of Malaria and Parasitic Disease, Korea National Institute of Health, Cheongwon Gun, Chungbuk, Korea
    PLoS ONE 7:e46553. 2012
    ..b>Babesia microti, an intraerythrocytic protozoan of the genus Babesia, is a major cause of the emerging human disease ..
  28. ncbi Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other treatment
    Ritchie C Shoemaker
    Center for Research on Biotoxin Associated Illnesses Pocomoke City, Maryland 21851, USA
    Adv Ther 23:1-11. 2006
    Ten percent of US patients with Lyme disease are coinfected with Babesia microti. A double-blind, placebo-controlled, crossover trial enrolled 25 patients with confirmed Borrelia burgdorferi/B microti coinfection, abnormal visual ..
  29. pmc Babesiosis due to the canine Babesia microti-like small piroplasm in dogs-first report from Portugal and possible vertical transmission
    Paula Brilhante Simões
    Inno Serviços Especializados em Veterinária, Braga, Portugal
    Parasit Vectors 4:50. 2011
    ..Three German shepherd dogs - a bitch and its 2-month old pup and an unrelated male - clinically suspected of piroplasmosis were assessed for babesial infection...
  30. pmc A new real-time PCR assay for improved detection of the parasite Babesia microti
    Allen E Teal
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany New York, USA
    J Clin Microbiol 50:903-8. 2012
    ..to a wider variety of laboratories, we developed a real-time PCR assay targeting the 18S rRNA gene of Babesia microti, the dominant babesiosis pathogen in the United States...
  31. ncbi Molecular evidence of prevalent dual piroplasma infections in North American raccoons (Procyon lotor)
    A J Birkenheuer
    North Carolina State University, College of Veterinary Medicine, Vector Borne Disease Diagnostic Laboratory, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Parasitology 135:33-7. 2008
    ..One genotype resides in the Babesia sensu stricto clade and the other in the Babesia microti-like clade...
  32. ncbi U.S.-type Babesia microti isolated from small wild mammals in Eastern Hokkaido, Japan
    Aya Zamoto
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    J Vet Med Sci 66:919-26. 2004
    Our previous report demonstrated that small wild rodents in Japan harbored two types of novel Babesia microti-like parasites (Kobe and Hobetsu types), but not the type widely distributed throughout the temperate zones of North American ..
  33. ncbi Prevalence of Babesia microti in Ixodes ricinus ticks from Lublin region (eastern Poland)
    Angelina Wójcik-Fatla
    Department of Occupational Biohazards, Institute of Agricultural Medicine, Jaczewskiego 2, 20 090 Lublin, Poland
    Ann Agric Environ Med 13:319-22. 2006
    ..ticks collected from 5 districts of the Lublin region (eastern Poland) were examined for the presence of Babesia microti DNA by PCR and nested-PCR. As many as 74 ticks (5.4 %) were found to be infected with Babesia microti...
  34. ncbi Survey of Babesia microti infection in field rodents in Japan: records of the Kobe-type in new foci and findings of a new type related to the Otsu-type
    Atsuko Saito-Ito
    Section of Parasitology, Division of Microbiology, Kobe University Graduate School of Medicine, Japan
    Microbiol Immunol 51:15-24. 2007
    Of 247 rodents comprising 5 genera and 7 species collected at 17 sites throughout Japan from 2003 to 2005, Babesia microti was detected microscopically and by polymerase chain reaction (PCR) in 36 rodents comprising 2 genera and 3 ..
  35. ncbi Identification and characterization of a novel secreted antigen 1 of Babesia microti and evaluation of its potential use in enzyme-linked immunosorbent assay and immunochromatographic test
    Yuzi Luo
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Parasitol Int 60:119-25. 2011
    Here, we identified a novel secreted antigen designated as Babesia microti secreted antigen 1 (BmSA1) by immunoscreening a B...
  36. ncbi Coincidence of three pathogens (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti) in Ixodes ricinus ticks in the Lublin macroregion
    Angelina Wójcik-Fatla
    Department of Occupational Biohazards, Institute of Agricultural Medicine, Lublin, Poland
    Ann Agric Environ Med 16:151-8. 2009
    ..to determine the coincidence of 3 pathogens: Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in Ixodes ricinus ticks in south-eastern Poland and to estimate the degree of infection with each of the ..
  37. ncbi Persistent detection of Babesia EU1 and Babesia microti in Ixodes ricinus in the Netherlands during a 5-year surveillance: 2003-2007
    Peter R Wielinga
    National Institute for Public Health and the Environment, The Netherlands
    Vector Borne Zoonotic Dis 9:119-22. 2009
    We report the finding of Babesia EU1 and Babesia microti in Ixodes ricinus ticks in the Netherlands...
  38. ncbi Case-control study of canine infection by a newly recognised Babesia microti-like piroplasm
    F J Guitian
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, North Mymms, Hertfordshire AL9 7TA, UK
    Prev Vet Med 61:137-45. 2003
    We did a case-control study to identify risk factors for prevalent infection of dogs by a newly recognised Babesia microti-like piroplasm. Clinical manifestations and haematology of infected dogs also were described...
  39. ncbi Effect of high- and low-molecular-weight components of Lactobacillus casei on resistance against Babesia microti in NIH mice
    Carlos R Bautista
    CENID PAVET, INIFAP, Jiutepec, Morelos, Mexico
    Ann N Y Acad Sci 1149:152-4. 2008
    ..components (LMWc and HMWc, respectively) of Lactobacillus casei on the resistance of mice to Babesia microti infection. In the first study, 23 components were identified in a total extract of L. casei by SDS-PAGE...
  40. pmc Babesiosis in Fairfield County, Connecticut
    John F Anderson
    Emerg Infect Dis 10:545-6. 2004
  41. ncbi Spontaneous splenic rupture caused by Babesia microti infection
    David P Kuwayama
    Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
    Clin Infect Dis 46:e92-5. 2008
    ..Although this complication is rare, practitioners who commonly treat patients with babesiosis should be aware of its potential occurrence...
  42. ncbi First confirmed autochthonous case of human Babesia microti infection in Europe
    A Hildebrandt
    Institute of Medical Microbiology, Friedrich Schiller University, Semmelweiss Str 4, 07743, Jena, Germany
    Eur J Clin Microbiol Infect Dis 26:595-601. 2007
    ..Suspicion of malaria was ruled out by use of a dip-stick test. The diagnosis of Babesia microti infection was finally established by specific polymerase chain reaction (PCR)...
  43. ncbi Babesia microti-like parasites detected in feral raccoons (Procyon lotor) captured in Hokkaido, Japan
    Takako Kawabuchi
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    J Vet Med Sci 67:825-7. 2005
    Raccoons (Procyon lotor), which have recently become feral in Japan, were examined for the presence of Babesia microti-like parasites...
  44. ncbi Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through 2007
    Stephanie T Johnson
    Transmissible Diseases Department, Jerome H Holland Laboratory, and Biomedical Services, American Red Cross, Farmington, Connecticut 06032, USA
    Transfusion 49:2574-82. 2009
    Current estimates of 70 cases of transfusion-transmitted Babesia microti, with 12 associated deaths, suggest that Babesia is a growing blood safety concern. The extent of Babesia infections among blood donors has not been well defined...
  45. ncbi Molecular survey of Babesia microti, Ehrlichia species and Candidatus neoehrlichia mikurensis in wild rodents from Shimane Prefecture, Japan
    Kenji Tabara
    The Shimane Prefectural Institute of Public Health and Environmental Science, Matsue, Shimane, Japan
    Microbiol Immunol 51:359-67. 2007
    ..We conducted molecular surveys for Babesia microti, Ehrlichia species, and Candidatus Neoehrlichia mikurensis in 62 FUO cases and 62 wild rodents from Shimane ..
  46. ncbi Babesia microti: prevalence in wild rodents and Ixodes ricinus ticks from the Mazury Lakes District of North-Eastern Poland
    Edward Sinski
    Department of Parasitology, Institute of Zoology, Warsaw University, Miecznikowa 1 Street, PL 02096 Warsaw, Poland
    Int J Med Microbiol 296:137-43. 2006
    Infections of Babesia microti (Apicomplexa, Piroplasmida), a common erythroparasitic protozoon of Holarctic rodents, are not widely acknowledged in Poland...
  47. ncbi Demonstrable parasitemia among Connecticut blood donors with antibodies to Babesia microti
    David A Leiby
    Department of Transmissible Diseases, American Red Cross, Rockville, MD 20855, USA
    Transfusion 45:1804-10. 2005
    Reports of transfusion-transmitted Babesia microti have risen steadily during the past several years, reflecting a concurrent increase in US cases of human babesiosis. Although several studies have measured B...
  48. ncbi What is Babesia microti?
    H K Goethert
    Department of Immunology and Infectious Diseases, 665 Huntington Avenue, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Parasitology 127:301-9. 2003
    b>Babesia microti (Apicomplexa: Piroplasmida) has historically been considered a common parasite of Holarctic rodents...
  49. ncbi Azotemia and mortality among Babesia microti-like infected dogs
    A Tomas Camacho
    Laboratorio Lema and Bandin, Calle Lepanto 5, bajo, 36201 Vigo, Spain
    J Vet Intern Med 18:141-6. 2004
    b>Babesia microti-like piroplasms are a recently recognized cause of illness in dogs in northwest Spain...
  50. ncbi The treatment of mice with Lactobacillus casei induces protection against Babesia microti infection
    C R Bautista-Garfias
    CENID PAVET, INIFAP Apdo, Postal 206, CIVAC, 62500 Estado de Morelos, Mexico
    Parasitol Res 97:472-7. 2005
    ..that administration of Lactobacillus casei confers protection to mice against the intracellular protozoan Babesia microti. Mice treated with L...
  51. ncbi Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection
    Gary P Wormser
    Divisions of 1Infectious Diseases, Departments of Medicine and 3Pathology, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 50:381-6. 2010
    Babesiosis is an emerging tickborne malaria-like infection principally caused by Babesia microti. This infection typically resolves either spontaneously or after administration of a 7-10-day course of azithromycin plus atovaquone or ..
  52. ncbi Glucose uptake activity in murine red blood cells infected with Babesia microti and Babesia rodhaini
    Takashi Ohmori
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:945-9. 2004
    ..One of two systems had no kinetical difference between B. rodhaini and B. microti IRBC, however another one might have higher uptake activity in B. microti IRBC compared to that in B. rodhaini IRBC...
  53. pmc Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis ticks collected in Northern New Jersey
    Martin E Adelson
    Medical Diagnostic Laboratories L L C, 133 Gaither Dr, Suite C, Mt Laurel, NJ 08054, USA
    J Clin Microbiol 42:2799-801. 2004
    ..6%), Babesia microti (8.4%), Anaplasma phagocytophila (1.9%), and Bartonella spp. (34.5%). The I...
  54. ncbi Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report
    Jatin M Vyas
    Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 45:1588-90. 2007
    ..Atovaquone-proguanil appears to have activity against babesiosis and should be studied as a potential therapy for patients with refractory babesiosis...
  55. pmc Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, southern coastal Maine
    Mary S Holman
    Maine Medical Center Research Institute, Portland, Maine, USA
    Emerg Infect Dis 10:744-6. 2004
    ..5%, 9.5%, and 1.9% of deer ticks were infected with Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti, respectively. In 1996 and 1997, the number of A. phagocytophilum-infected ticks markedly declined...
  56. ncbi Investigation of transfusion transmission of a WA1-type babesial parasite to a premature infant in California
    Anne M Kjemtrup
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis 95616 8745, USA
    Transfusion 42:1482-7. 2002
    ..The infant had received two blood transfusions, one from the father and one from an anonymous donor (Donor A). This study describes the follow-up required to identify the source and species of Babesia that infected the infant...
  57. ncbi Identification of Babesia microti-specific immunodominant epitopes and development of a peptide EIA for detection of antibodies in serum
    Raymond L Houghton
    Department of Antigen Discovery, Corixa Corporation, Seattle, Washington 98104, USA
    Transfusion 42:1488-96. 2002
    b>Babesia microti is a tick-borne agent that is increasingly implicated in transfusion-acquired infection, especially in immunocompromised and elderly recipients. To develop a test that can detect antibody responses to B...
  58. pmc Identification and characterization of putative secreted antigens from Babesia microti
    Mary J Homer
    Corixa Corporation, Seattle, Washington 98104, USA
    J Clin Microbiol 41:723-9. 2003
    The need for improved diagnostic reagents to identify human long-term carriers of the zoonotic parasite Babesia microti is evidenced by numerous reported cases of transfusion-acquired infections...
  59. pmc Human Babesia microti incidence and Ixodes scapularis distribution, Rhode Island, 1998-2004
    Sarah E Rodgers
    University of Rhode Island, Kingston, Rhode Island 02881, USA
    Emerg Infect Dis 13:633-5. 2007
    ..Although the incidence of babesiosis is increasing in southern Rhode Island, large areas of the state are free of babesiosis risk...
  60. ncbi Case report: spontaneous splenic rupture during acute parasitemia of Babesia microti
    M Kent Froberg
    Department of Pathology, University of Minnesota, School of Medicine, and Duluth Clinic, Duluth, MN, USA
    Ann Clin Lab Sci 38:390-2. 2008
    ..Typically it causes subclinical disease, but occasionally causes acute febrile disease with hepatosplenomegaly. We report a case of spontaneous splenic rupture of a 56-yr-old man with acute Babesia microti infection.
  61. ncbi Increasing health burden of human babesiosis in endemic sites
    Peter J Krause
    Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Am J Trop Med Hyg 68:431-6. 2003
    Human infection due to Babesia microti has been regarded as infrequent and a condition primarily affecting the elderly or immunocompromised...
  62. pmc Babesia microti, upstate New York
    Sarah J Kogut
    New York State Department of Health, Troy, New York, USA
    Emerg Infect Dis 11:476-8. 2005
    ..An investigation to determine if Babesia microti was present in local Ixodes scapularis ticks yielded 5 positive pools in 123 pools tested, the first ..
  63. ncbi Evidence of Babesia microti infection in multi-infected Ixodes persulcatus ticks in Russia
    Andrey N Alekseev
    Zoological Institute, Russian Academy of Sciences, Universitetskaya Nab, 1, 199034 St Petersburg, Russia
    Exp Appl Acarol 29:345-53. 2003
    ..Ehrlichia spp. and tick-borne encephalitis virus (TBEV). All 7 ticks infected with Babesia microti, were also infected with other pathogens (all 7 among 417 infected ticks, zero amongst the remaining 321 ..
  64. ncbi Enzootic Babesia microti in Maine
    H K Goethert
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Parasitol 89:1069-71. 2003
    Human babesiosis in the northeastern United States caused by Babesia microti (Apicomplexa: Piroplasmida) is mainly reported from coastal New England sites, where deer ticks (Ixodes dammini) are common...
  65. ncbi Babesia sp.: emerging intracellular parasites in Europe
    Jeremy S Gray
    Department of Environmental Resource Management, University College Dublin, Dublin 4, Republic of Ireland
    Pol J Microbiol 53:55-60. 2004
    ..tools has made possible a reappraisal of the main parasites involved (Babesia divergens in Europe and Babesia microti in the USA). B...
  66. ncbi [Babesosis--difficulty of diagnosis]
    A Cichocka
    Katedra Genetyki, , 71-065 Szczecin,
    Wiad Parazytol 47:527-33. 2001
    ..With the evolution PCR--based techniques, the diagnosis and monitoring of babesial infections became more sensitive and reliable...
  67. ncbi Transmission of Babesia microti in Minnesota through four blood donations from the same donor over a 6-month period
    Barbara L Herwaldt
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Transfusion 42:1154-8. 2002
    Babesiosis is a tick-borne zoonosis caused by intraerythrocytic protozoa. More than 40 US cases of Babesia microti infection acquired by blood transfusion have been reported...
  68. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2003. A 60-year-old man with fever, rigors, and sweats
    Joshua D Gutman
    Family Medicine Associates, South Attleboro, Mass, USA
    N Engl J Med 349:1168-75. 2003
  69. ncbi Can ticks be vectors for hepatitis C virus?
    Lois Gitlin Wurzel
    N Engl J Med 347:1724-5. 2002
  70. ncbi Babesia microti and Borrelia burgdorferi coinfection associated with increased severity of arthritis
    Manuel H Moro
    J Infect Dis 194:716. 2006
  71. ncbi Odour learning and immunity costs in mice
    C J Barnard
    Animal Behaviour Research Group, School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Behav Processes 72:74-83. 2006
    ..That subsequent infection with Babesia microti increased with the number of odours mice had to learn is then consistent with an increased cost to learning ..
  72. ncbi Chemotherapy against babesiosis
    Henri J Vial
    Dynamique Moleculaire des Interactions Membranaires, UMR 5539 CNRS Université Montpellier II, Case 107, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Vet Parasitol 138:147-60. 2006
    ..Some Babesia spp. can infect humans, particularly Babesia microti and Babesia divergens, and human babesiosis is a significant emerging tick-borne zoonotic disease...
  73. ncbi [Prevalence of antibodies against Anaplasma phagocytophilum, Babesia microti i Borrelia burgdorferi in adults in North-Eastern Poland]
    Jarosław Walory
    Zespół Badarń Mikrobiologicznych, Narodowy Instytut Zdrowia Publicznego w Warszawie
    Pol Merkur Lekarski 19:754-7. 2005
    of the study was to evaluate the seroprevalance of antibodies against Anaplasma phagocytophilum and Babesia Microti in healthy north-eastern Poland, adult population.
  74. ncbi The prevalence of piroplasms in a population of Ixodes ricinus (Acari: Ixodidae) from north-western Poland
    Wanda Kuzna-Grygiel
    Department of Biology and Medical Parasitology, Pomeranian Medical University, Szczecin, Poland
    Ann Agric Environ Med 9:175-8. 2002
    ..The same ticks were also hosts to Babesia microti, which was determined by PCR amplification with primers specific to the fragment of a gene encoding the ..
  75. ncbi Japanese Babesia microti cytologically detected in salivary glands of naturally infected tick Ixodes ovatus
    Yasuhiro Yano
    Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Japan
    Microbiol Immunol 49:891-7. 2005
    b>Babesia microti protozoa were detected by light and electron microscopy in the salivary glands of field-collected Ixodes ovatus ticks; 6 of 85 adult ticks were demonstrated to be positive for B...
  76. ncbi Transverse myelitis secondary to coexistent Lyme disease and babesiosis
    Christina V Oleson
    Department of Rehabilitation Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    J Spinal Cord Med 26:168-71. 2003
    ..To describe transverse myelitis secondary to coexistent Lyme disease and babesiosis...
  77. ncbi Atovaquone and azithromycin treatment for babesiosis in an infant
    Mina Raju
    Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Pediatr Infect Dis J 26:181-3. 2007
    An 8-month-old infant with cyanotic heart disease and transfusion-associated Babesia microti infection is reported here. At initial presentation, she was ill appearing, febrile and cyanotic...
  78. ncbi Coinfection in patients with lyme disease: how big a risk?
    Raphael B Stricker
    Clin Infect Dis 37:1277-8; author reply 1278-9. 2003
  79. ncbi Age-associated decline in resistance to Babesia microti is genetically determined
    Edouard Vannier
    Division of Infectious Diseases, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Infect Dis 189:1721-8. 2004
    Although infection by the protozoan Babesia microti is rarely symptomatic in immunocompetent young people, healthy individuals aged >50 years may experience life-threatening disease...
  80. ncbi Babesia: the protective effects of killed Propionibacterium acnes on the infections of two rodent Babesia parasites in mice
    Hiroshi Iseki
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Exp Parasitol 118:543-8. 2008
    ..acnes on rodent babesiosis even with different immune responses between the B. microti and B. rodhaini infections. Killed P. acnes might be a powerful tool for the control of serious livestock babesiosis...
  81. ncbi [Tick-borne diseases and ecosystem modifications in Lorraine]
    M Marjolet
    Bull Soc Pathol Exot 95:304. 2002
  82. ncbi Factors affecting the component community structure of haemoparasites in common voles ( Microtus arvalis) from the Mazury Lake District region of Poland
    A Pawelczyk
    Department of Parasitology, Institute of Zoology, University of Warszawa, Miecznikowa 1 Street, 02 096 Warszawa, Poland
    Parasitol Res 92:270-84. 2004
    ..Total species richness was five (prevalence= Haemobartonella sp. 63.9%, Bartonella spp. 27.7%, Babesia microti 9.0%, Trypanosoma sp. 8.4% and and Hepatozoon lavieri 3.1%) with 76...
  83. ncbi Photochemical inactivation with amotosalen and long-wavelength ultraviolet light of Plasmodium and Babesia in platelet and plasma components
    Philippe Grellier
    Biologie Fonctionnelle des Protozoaires, Museum national d histoire naturelle, Paris, France
    Transfusion 48:1676-84. 2008
    ....
  84. ncbi [Babesia microti: a new form of human babesiosis in Europe?]
    Angel Tomas Camacho
    Enferm Infecc Microbiol Clin 20:417-8. 2002
  85. ncbi Babesia microti: parasitaemia and antibody responses to primary and challenge infections in BALB/c mice
    Katarzyna Pastusiak
    Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Twarda 51 55, 00 818 Warszawa, Poland
    Folia Parasitol (Praha) 50:237-9. 2003
  86. pmc Survey of rodents and ticks in human babesiosis emergence area in Japan: first detection of Babesia microti-like parasites in Ixodes ovatus
    Atsuko Saito-Ito
    Section of Parasitology, Department of Genome Sciences, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Clin Microbiol 42:2268-70. 2004
    b>Babesia microti-like parasites were detected for the first time in Ixodes ovatus in Hyogo Prefecture, Japan, where two reported types of B. microti-like parasites were recognized in many rodents. Of 80 adult I...
  87. ncbi Susceptibility of Chinese hamsters (Cricetulus griseus) to the infection of Babesia microti
    Kazunori Ike
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180 8602, Japan
    J Vet Med Sci 67:333-6. 2005
    Chinese hamsters were examined for the susceptibility to the infection with Babesia microti based on the hematological parameters during the course of infection...
  88. ncbi Detection of extracellular forms of babesia in the blood by electron microscopy: a diagnostic method for differentiation from Plasmodium falciparum
    William J Carter
    New York University School of Medicine, New York, New York, USA
    Ultrastruct Pathol 27:211-6. 2003
    ..The test had a reasonably fast turnaround time and allowed detailed visualization of the organisms and reliable distinction from Plasmodium falciparum...
  89. ncbi Detection of Kobe-type Babesia microti associated with Japanese human babesiosis in field rodents in central Taiwan and southeastern mainland China
    A Saito-Ito
    Section of Parasitology, Division of Microbiology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Parasitology 135:691-9. 2008
    ..b>Babesia microti was identified by microscopical examination and/or PCR in 1 Rattus coxinga and 1 Crocidura horsfieldii in ..
  90. ncbi Infection and co-infection rates of Anaplasma phagocytophilum variants, Babesia spp., Borrelia burgdorferi, and the rickettsial endosymbiont in Ixodes scapularis (Acari: Ixodidae) from sites in Indiana, Maine, Pennsylvania, and Wisconsin
    Fresia E Steiner
    Department of Biology, Ball State University, Muncie, IN 47306, USA
    J Med Entomol 45:289-97. 2008
    ..sites were analyzed by polymerase chain reaction (PCR) for five microbial species: Anaplasma phagocytophilum, Babesia microti, Babesia odocoilei, Borrelia burgdorferi, and the rickettsial I. scapularis endosymbiont...
  91. ncbi Pathogens and symbionts in ticks: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp., Rickettsia sp., and Babesia sp. in Southern Germany
    Kathrin Hartelt
    Baden Wuerttemberg State Health Office, Stuttgart, Germany
    Int J Med Microbiol 293:86-92. 2004
    ..0%) were identified as Babesia divergens. Three of all Babesia-positive ticks were identified as harboring Babesia microti. The detection of Anaplasma phagocytophilum, Rickettsia sp. and Babesia sp...
  92. ncbi Ticks and associated pathogens collected from domestic animals in the Netherlands
    Ard M Nijhof
    Utrecht Centre for Tick borne Diseases UCTD, Department of Immunology and Infectious Diseases, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Vector Borne Zoonotic Dis 7:585-95. 2007
    ..4%), Anaplasma phagocytophilum (1.6%), Babesia sp. (EU1) (1.2%), Babesia divergens (0.4%), and Babesia microti (0.4%). A. phagocytophilum (5.9%) and R. helvetica (0.8%) were also detected in adult I. hexagonus ticks...
  93. pmc Risk of Lyme disease: perceptions of residents of a Lone Star tick-infested community
    P M Armstrong
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA
    Bull World Health Organ 79:916-25. 2001
    ..typhi (0%), Coxiella burneti (0%), Francisella tularensis (0%), and Babesia microti (0%) by standard serological methods for 325 residents (97% of the total population) of Gibson Island, ..
  94. ncbi Coexistence DNA of Borrelia burgdorferi sensu lato and Babesia microti in Ixodes ricinus ticks from north-western Poland
    Bogumiła Skotarczak
    Faculty of Biology, Department of Genetics, University of Szczecin, Piastow 40B, 71 065 Szczecin, Poland
    Ann Agric Environ Med 9:25-8. 2002
    ..caused by the spirochaete Borrelia burgdorferi sensu lato and babesiosis, induced by the protozoan Babesia microti. Both microbe species may co-occur in the same and other species of the genus tick and produce a mixed ..
  95. pmc Infection with agents of human granulocytic ehrlichiosis, lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut
    K C Stafford
    The Connecticut Agricultural Experiment Station, New Haven, Connecticut 06504, USA
    J Clin Microbiol 37:2887-92. 1999
    ..Borrelia burgdorferi, and Babesia microti. Of the 50 mice captured and recaptured, 25 of 47 (53.2%) and 23 of 48 (47...
  96. pmc Co-circulating microorganisms in questing Ixodes scapularis nymphs in Maryland
    Katherine I Swanson
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Vector Ecol 32:243-51. 2007
    Ixodes scapularis can be infected with Borrelia burgdorferi, Anaplasma phagocytophilum, Bartonella spp., Babesia microti, and Rickettsia spp., including spotted-fever group Rickettsia...
  97. pmc Detection of enzootic babesiosis in baboons (Papio cynocephalus) and phylogenetic evidence supporting synonymy of the genera Entopolypoides and Babesia
    M A Bronsdon
    Regional Primate Research Center, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Microbiol 37:1548-53. 1999
    ..macaci demonstrated this parasite to be most closely related to Babesia microti (97...
  98. ncbi Theobald Smith--the discoverer of ticks as vectors of disease
    Ojan Assadian
    Clinical Institute of Hygiene and Medical Microbiology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 114:479-81. 2002
    ..Furthermore, by proving that ticks carry Babesia microti--which causes babesiosis in animals and humans--this is the first account of a zoonotic disease and the ..
  99. pmc Immunoserologic evidence of coinfection with Borrelia burgdorferi, Babesia microti, and human granulocytic Ehrlichia species in residents of Wisconsin and Minnesota
    P D Mitchell
    Microbiology Section, Marshfield Laboratories, WI 54449, USA
    J Clin Microbiol 34:724-7. 1996
    ..diseases include Lyme borreliosis, which is caused by Borrelia burgdorferi, babesiosis, which is caused by Babesia microti, and human granulocytic ehrlichiosis (HGE), which is caused by an apparently new species in the genus ..
  100. pmc Human exposure to a granulocytic Ehrlichia and other tick-borne agents in Connecticut
    L A Magnarelli
    Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, Connecticut 06504, USA
    J Clin Microbiol 36:2823-7. 1998
    ..Also included were other tests for Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis (HME), Babesia microti, and Borrelia burgdorferi. Thirty-three (8...
  101. ncbi Coexistence of Borrelia spp. and Babesia spp. in Ixodes ricinus ticks in Middle Germany
    Anke Hildebrandt
    Institute of Medical Microbiology, Friedrich Schiller University, Jena, Germany
    Vector Borne Zoonotic Dis 10:831-7. 2010
    ..occurred. Babesia spp.-specific DNA was detected in 5.0% of ticks. Babesia microti was slightly more prevalent (28/50) than Babesia divergens (20/50). Moreover, 5.9% (16/270) of Borrelia spp...

Research Grants35

  1. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among other pathogens. A. phagocytophilum and B...
  2. Babesiosis Emergence in the United States
    MARIA ANA DIUK-WASSER; Fiscal Year: 2013
    ..Human babesiosis is a rapidly emerging tick-borne zoonosis in the United States caused by the protozoan Babesia microti and transmitted by Ixodes scapularis, the Lyme disease vector...
  3. Babesiosis: An Emerging Infectious Threat to Transfusion Medicine
    Cheryl Ann Lobo; Fiscal Year: 2013
    ..The rodent parasite, Babesia microti and the bovine pathogen, Babesia divergens are responsible for most of the human infections that have been ..
  4. R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)
    Andrew Levin; Fiscal Year: 2012
    ..This project is aimed at the development of an enzyme immunoassay (ELISA) for screening blood for antibodies to Babesia microti. Human babesiosis is a malaria-like illness due to infection of red blood cells by various species of ..
  5. Babesiosis as a model of age-related immunosenescence
    Henry H Wortis; Fiscal Year: 2012
    ..We developed a mouse model of human babesiosis due Babesia microti, an emerging infection particularly severe in the aged...
  6. A prospective evaluation of chronic B.microti infection in seroreactive blood don
    EVAN MARTIN BLOCH; Fiscal Year: 2013
    ..is well described: 162 cases of TTB have been reported in the US alone, the overwhelming majority caused by Babesia microti, which is widely endemic in the Northeastern and upper Midwestern US...
  7. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
    ..The genes targeted will be OspB for B. burgdorferi, the 16S-like gene for Babesia microti and the 1 6S rRNA gene for Ehrlichia (HGE)...
  8. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 2001
    ..of tick-borne infections has shown that many individuals infected with Lyme disease have co-infections with Babesia microti (agent of human babesiosis) and Ehrlichia, both of which are potentially fatal in immunocompromised ..
  9. NATURAL HISTORY OF BABESIOSIS
    Peter Wettstein; Fiscal Year: 1999
    The blood parasite Babesia microti and the spirochetal agent of Lyme disease, B. burgdorferi, are both transmitted by the deer tick, Ixodes dammini ( also called I...
  10. RISK OF TBE IN NORTH AMERICA FOCI OF LYME DISEASE
    Andrew Spielman; Fiscal Year: 1992
    ..with the prevalence of spirochetal and of viral infection in the vector; (3) measure the prevalence of Babesia microti and of Ba...
  11. TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
    Sam Telford; Fiscal Year: 2000
    ..and inbred mice, as well as Peromyscus leucopus, the main enzootic reservoir of Borrelia burgdorferi and Babesia microti in the northeastern U.S...
  12. Vaccination Against Ixodes scapularis Tick Bites
    Raymond Koski; Fiscal Year: 2001
    ..burgdorferi, the agent of human granulocytic ehrlichiosis, and Babesia microti. The commercial market would overlap with the market for LYMErix, a Lyme disease vaccine successfully sold by ..
  13. DEVELOPMENT OF PCR BASED ASSAY FOR BABESIOSIS
    BITA NAKHAI; Fiscal Year: 1999
    ..Ultimately, (in Phase II) a multiplex PCR assay for simultaneous detection of Borrelia burgdorferi, Babesia microti, Ehrlichia chaffeensis and E...
  14. Vaccination Against Ixodes scapularis Tick Bites
    Michel Ledizet; Fiscal Year: 2003
    ..burgdorferi, Babesia microti, and the agent of human granulocytic ehrlichiosis...
  15. Comparison of US and European Babesia divergens Isolates
    Patricia Holman; Fiscal Year: 2004
    ..Two other Babesia species that cause human Babesiosis in the US, Babesia microti, occurring mostly in the northeastern U.S...
  16. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
  17. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  18. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ....
  19. Perpetuation of Francisella tularensis
    Sam R Telford; Fiscal Year: 2010
    ..Taken together, these observations will provide a basis for understanding how the agent of tularemia is perpetuated on Martha's Vineyard, and why pneumonic human disease is prevalent there. ..
  20. ROLE OF TICK SALIVA IN LYME DISEASE AND VACCINE STRATEGY
    Thomas Mather; Fiscal Year: 2006
    ..We expect these studies to lead to new vaccination strategies that combine tick and bacterial elements for preventing Lyme disease, and possibly a broader range of tick-transmitted infections. ..
  21. Assessing Community-Based Tick Control for LD Mitigation
    Thomas Mather; Fiscal Year: 2007
    ..Efforts will focus on identifying strategiesfor engaging the community and individuals at risk. ..
  22. Proximal determinants of risk for tularemia outbreaks
    Sam Telford; Fiscal Year: 2004
    ..tularensis in the environment; and, ultimately, a better understanding of F. tularensis-host interactions. ..
  23. TOXOPLASMA ENCEPHALITIS IN AIDS: BRADYZOITE REGULATION
    Louis Weiss; Fiscal Year: 2009
    ....
  24. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  25. Microsporidiosis:A Therapeutic Target
    Louis Weiss; Fiscal Year: 2003
    ....
  26. Gene expression of Borrelia during Babesia coinfection
    James Coleman; Fiscal Year: 2004
    Coinfection with Borrelia burgdorferi and Babesia microti is a clinically documented, emerging public health concern in the Northeastern United States...
  27. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
    ..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
  28. Second International Workshop on Microsporidia from Vertebrate and Invertebrate H
    Louis Weiss; Fiscal Year: 2007
    ..Overall, the goal of this[unreadable] congress is to foster the exchange of information between these diverse groups of[unreadable] scientists leading to advances in research on these emergent pathogens. ..
  29. International Congress on Microsporidiosis
    Louis Weiss; Fiscal Year: 2004
    ..Overall, the goal of this congress is to foster the exchange of information between these diverse groups of scientists leading to advances in research on these emergent pathogens. ..
  30. A Therapeutic Target for Microsporidiosis
    Louis Weiss; Fiscal Year: 2007
    ..In addition, the approaches and methods developed in this R21 should also prove useful for studies on methionine aminopeptidases as therapeutic targets in other pathogenic protists. [unreadable] [unreadable] [unreadable]..
  31. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Modulation of Dendritic Cell Function by Cytomegalovirus
    JATIN VYAS; Fiscal Year: 2008
    ..The proposed program will allow the candidate to obtain the skills, knowledge and experience to become an independent investigator. ..