trypanosoma

Summary

Summary: A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.

Top Publications

  1. ncbi Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism
    R Luise Krauth-Siegel
    Biochemie Zentrum der Universitat Heidelberg, 69120 Heidelberg, Germany
    Biochim Biophys Acta 1780:1236-48. 2008
  2. pmc Cell biology of the trypanosome genome
    Jan Peter Daniels
    University of Oxford, Oxford, United Kingdom
    Microbiol Mol Biol Rev 74:552-69. 2010
  3. pmc Microbiome influences on insect host vector competence
    Brian Weiss
    Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520, USA
    Trends Parasitol 27:514-22. 2011
  4. ncbi Epigenetics and transcriptional control in African trypanosomes
    Gloria Rudenko
    Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW72AZ, UK
    Essays Biochem 48:201-19. 2010
  5. ncbi Post-transcriptional regulation of gene expression in trypanosomes and leishmanias
    Christine Clayton
    Zentrum für Molekualre Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, D69120 Heidelberg, Germany
    Mol Biochem Parasitol 156:93-101. 2007
  6. ncbi Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity
    Liam J Morrison
    University of Glasgow, Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, 120 University Place, Glasgow, G12 8TA, UK
    Cell Microbiol 11:1724-34. 2009
  7. pmc Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug
    Rani Pallavi
    Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka 560012, India
    J Biol Chem 285:37964-75. 2010
  8. pmc The role of deadenylation in the degradation of unstable mRNAs in trypanosomes
    Angela Schwede
    Zentrum für Molekulare Biologie ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Nucleic Acids Res 37:5511-28. 2009
  9. ncbi A phyto-sociological analysis of the distribution of riverine tsetse flies in Burkina Faso
    J Bouyer
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, Département élevage et médecine vétérinaire, Montpellier, France
    Med Vet Entomol 19:372-8. 2005
  10. ncbi Grouping of trypanosome species in mixed infections in Glossina pallidipes
    M J Lehane
    School of Biological Sciences, University of Wales, Bangor, UK
    Parasitology 120:583-92. 2000

Detail Information

Publications266 found, 100 shown here

  1. ncbi Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism
    R Luise Krauth-Siegel
    Biochemie Zentrum der Universitat Heidelberg, 69120 Heidelberg, Germany
    Biochim Biophys Acta 1780:1236-48. 2008
    ..Thus, cellular thiol redox homeostasis is maintained by the biosynthesis and reduction of trypanothione. Nearly all proteins of the parasite-specific trypanothione metabolism have proved to be essential...
  2. pmc Cell biology of the trypanosome genome
    Jan Peter Daniels
    University of Oxford, Oxford, United Kingdom
    Microbiol Mol Biol Rev 74:552-69. 2010
    ..We also compare this nuclear organization to those in other systems in order to shed light on the evolution of nuclear architecture in eukaryotes...
  3. pmc Microbiome influences on insect host vector competence
    Brian Weiss
    Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520, USA
    Trends Parasitol 27:514-22. 2011
    ....
  4. ncbi Epigenetics and transcriptional control in African trypanosomes
    Gloria Rudenko
    Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW72AZ, UK
    Essays Biochem 48:201-19. 2010
    The African trypanosome Trypanosoma brucei is a unicellular parasite which causes African sleeping sickness...
  5. ncbi Post-transcriptional regulation of gene expression in trypanosomes and leishmanias
    Christine Clayton
    Zentrum für Molekualre Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, D69120 Heidelberg, Germany
    Mol Biochem Parasitol 156:93-101. 2007
    ..Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated...
  6. ncbi Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity
    Liam J Morrison
    University of Glasgow, Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, 120 University Place, Glasgow, G12 8TA, UK
    Cell Microbiol 11:1724-34. 2009
    ....
  7. pmc Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug
    Rani Pallavi
    Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka 560012, India
    J Biol Chem 285:37964-75. 2010
    ..In addition, we have explored the potential of Hsp90 inhibitors as drugs for the treatment of Trypanosoma infection in animals...
  8. pmc The role of deadenylation in the degradation of unstable mRNAs in trypanosomes
    Angela Schwede
    Zentrum für Molekulare Biologie ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Nucleic Acids Res 37:5511-28. 2009
    ..The results support a model in which trypanosome mRNAs can be degraded by at least two different, partially independent, cytoplasmic degradation pathways attacking both ends of the mRNA...
  9. ncbi A phyto-sociological analysis of the distribution of riverine tsetse flies in Burkina Faso
    J Bouyer
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, Département élevage et médecine vétérinaire, Montpellier, France
    Med Vet Entomol 19:372-8. 2005
    ..tachinoides in half-disturbed Sudanese gallery forest sites, confirming their high resilience to human-made changes. The importance of a detailed consideration of riverine ecotypes when predicting tsetse densities is discussed...
  10. ncbi Grouping of trypanosome species in mixed infections in Glossina pallidipes
    M J Lehane
    School of Biological Sciences, University of Wales, Bangor, UK
    Parasitology 120:583-92. 2000
    ..analysis suggests that mixed infections group into 3 largely separate divisions among the tsetse population (i) Trypanosoma congolense savannah and T. congolense Kenya coast, (ii) T. simiae, T. congolense Tsavo and T...
  11. ncbi Phylogeographical, ecological and biological patterns shown by nuclear (ssrRNA and gGAPDH) and mitochondrial (Cyt b) genes of trypanosomes of the subgenus Schizotrypanum parasitic in Brazilian bats
    Manzelio Cavazzana
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    Int J Parasitol 40:345-55. 2010
    The genetic diversity and phylogeographical patterns of Trypanosoma species that infect Brazilian bats were evaluated by examining 1043 bats from 63 species of seven families captured in Amazonia, the Pantanal, Cerrado and the Atlantic ..
  12. ncbi Experimental transmission of the parasitic flagellates Trypanosoma cruzi and Trypanosoma rangeli between triatomine bugs or mice and captive neotropical bats
    Maurice E Thomas
    Department of Obstetrics and Gynecology, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA
    Mem Inst Oswaldo Cruz 102:559-65. 2007
    b>Trypanosoma cruzi and Trypanosoma rangeli-like trypanosomes have been found in a variety of neotropical bat species...
  13. ncbi Trypanosomes are monophyletic: evidence from genes for glyceraldehyde phosphate dehydrogenase and small subunit ribosomal RNA
    Patrick B Hamilton
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Int J Parasitol 34:1393-404. 2004
    The genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major have been sequenced, but the phylogenetic relationships of these three protozoa remain uncertain...
  14. ncbi Mammalian cell invasion by closely related Trypanosoma species T. dionisii and T. cruzi
    Fernando Yukio Maeda
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, R Pedro de Toledo, Brazil
    Acta Trop 121:141-7. 2012
    Protozoan parasites of the genus Trypanosoma can infect virtually all mammalian species...
  15. ncbi Trypanosoma rangeli isolates of bats from Central Brazil: genotyping and phylogenetic analysis enable description of a new lineage using spliced-leader gene sequences
    F Maia da Silva
    Departamento de Parasitologia, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Acta Trop 109:199-207. 2009
    b>Trypanosoma rangeli infects several mammalian orders but has never confidently been described in Chiroptera, which are commonly parasitized by many trypanosome species...
  16. ncbi Tsetse fly blood meal modification and trypanosome identification in two sleeping sickness foci in the forest of southern Cameroon
    Oumarou Farikou
    University of Yaounde I, Faculty of Science, P O Box 812, Yaounde, Cameroon
    Acta Trop 116:81-8. 2010
    ..12.6%, 8.1% and 2.7% of the flies were, respectively, Trypanosoma congolense forest type, Trypanosoma congolense savannah type and Trypanosoma brucei gambiense infected...
  17. ncbi African trypanosomes: celebrating diversity
    Emily R Adams
    Koninklijk Instituut voor de Tropen KIT Biomedical Research, Amsterdam 1105 AZ, Netherlands
    Trends Parasitol 26:324-8. 2010
    ..We should first acknowledge that these novel trypanosomes exist and then take steps to investigate their host range, pathogenicity to livestock and response to chemotherapy...
  18. ncbi Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species
    Chatchawan Changtam
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Ramkhamhaeng Road, Bangkok 10240, Thailand
    Eur J Med Chem 45:941-56. 2010
    ..of curcuminoid analogs and these parent curcuminoids and their analogs were assessed against protozoa of the Trypanosoma and Leishmania species...
  19. ncbi Bloodstream form Trypanosome plasma membrane proteins: antigenic variation and invariant antigens
    Angela Schwede
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB21GA, UK
    Parasitology 137:2029-39. 2010
    b>Trypanosoma brucei is exposed to the adaptive immune system and complement in the blood of its mammalian hosts...
  20. ncbi The parasite-specific trypanothione metabolism of trypanosoma and leishmania
    R Luise Krauth-Siegel
    Center of Biochemistry, University of Heidelberg, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
    Biol Chem 384:539-49. 2003
    ....
  21. ncbi Modulation of Trypanosoma rangeli ecto-phosphatase activity by hydrogen peroxide
    Daniela Cosentino-Gomes
    Instituto de Bioquímica Médica and Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Ilha do Fundao, 21941 590 Rio de Janeiro, RJ, Brazil
    Free Radic Biol Med 47:152-8. 2009
    As a protozoan parasite of hematophagous insects, Trypanosoma rangeli epimastigotes are exposed to reactive oxygen species during development in hosts...
  22. pmc Molecular epidemiology of camel trypanosomiasis based on ITS1 rDNA and RoTat 1.2 VSG gene in the Sudan
    Bashir Salim
    Department of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001 0020, Japan
    Parasit Vectors 4:31. 2011
    ....
  23. ncbi Sleeping sickness--a re-emerging disease in the Serengeti?
    Magai T Kaare
    Department of Veterinary Medicine and Public Health, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P O Box 3021, Morogoro, Tanzania
    Travel Med Infect Dis 5:117-24. 2007
    ..PCR analysis, directed against the human serum resistance associated gene SRA, identified human infective Trypanosoma brucei rhodesiense parasites in both cattle and warthogs.
  24. pmc Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
    Jingwen Wang
    Department of Epidemiology of Microbial Diseases, Yale School of Public Heath, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:12133-8. 2009
    ..A dynamic interplay between Wigglesworthia and host immunity apparently is influential in tsetse's ability to transmit trypanosomes...
  25. pmc Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections
    B Bucheton
    Institut de recherche pour le developpement IRD, Unité Mixte de Recherche IRD CIRAD 177, Campus International de Baillarguet, Montpellier, France
    Parasite Immunol 33:438-47. 2011
    ..Increasing data however argue that infection by Trypanosoma brucei gambiense, the causative agent of HAT, results in a wide range of outcomes in its human host and ..
  26. pmc Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
    De Hua Lai
    Biology Centre, Institute of Parasitology, Czech Academy of Sciences, 37005 Ceske Budejovice, Czech Republic
    Proc Natl Acad Sci U S A 105:1999-2004. 2008
    b>Trypanosoma brucei is a kinetoplastid flagellate, the agent of human sleeping sickness and ruminant nagana in Africa...
  27. ncbi Species-specific loop-mediated isothermal amplification (LAMP) for diagnosis of trypanosomosis
    Oriel M M Thekisoe
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Acta Trop 102:182-9. 2007
    ..8S rRNA-internal transcribed spacer 2 (ITS2) gene for Trypanosoma brucei gambiense, 18S rRNA for both T. congolense and T. cruzi, and VSG RoTat 1.2 for T. evansi...
  28. pmc RNA polymerase transcription machinery in trypanosomes
    Anish Das
    Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, 225 Warren St, Newark, NJ 07103, USA
    Eukaryot Cell 7:429-34. 2008
  29. pmc Repertoire, genealogy and genomic organization of cruzipain and homologous genes in Trypanosoma cruzi, T. cruzi-like and other trypanosome species
    Luciana Lima
    Departamento de Parasitologia, ICB, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brasil
    PLoS ONE 7:e38385. 2012
    b>Trypanosoma cruzi, the agent of Chagas disease, is a complex of genetically diverse isolates highly phylogenetically related to T...
  30. ncbi Molecular cloning and functional characterisation of a cathepsin L-like proteinase from the fish kinetoplastid parasite Trypanosoma carassii
    Aleksandra Ruszczyk
    Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, Wageningen, The Netherlands
    Fish Shellfish Immunol 24:205-14. 2008
    b>Trypanosoma carassii is a fish kinetoplastid parasite that belongs to the family Trypanosomatida. In the present study we cloned a cathepsin L-like proteinase from T. carassii...
  31. ncbi Trypanosoma irwini n. sp (Sarcomastigophora: Trypanosomatidae) from the koala ( Phascolarctos cinereus)
    L M McInnes
    Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Perth 6150, Western Australia
    Parasitology 136:875-85. 2009
    ..18S rDNA and gGAPDH loci demonstrated this trypanosome species to be genetically distinct and most similar to Trypanosoma bennetti, an avian trypanosome with a genetic distance of 0.9% at the 18S rDNA and 10.7% at the gGAPDH locus...
  32. ncbi Novel trypanosome Trypanosoma gilletti sp. (Euglenozoa: Trypanosomatidae) and the extension of the host range of Trypanosoma copemani to include the koala ( Phascolarctos cinereus)
    L M McInnes
    Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Perth, WA 6150, Australia
    Parasitology 138:59-70. 2011
    b>Trypanosoma irwini was previously described from koalas and we now report the finding of a second novel species, T. gilletti, as well as the extension of the host range of Trypanosoma copemani to include koalas...
  33. ncbi Landmarks in the evolution of technologies for identifying trypanosomes in tsetse flies
    John C Enyaru
    Department of Biochemistry, Makerere University, P O Box 7062, Kampala, Uganda
    Trends Parasitol 26:388-94. 2010
    ..Over this period, methods for detecting and identifying trypanosomes have evolved through various landmark discoveries. This review describes the evolution of methods for identifying African trypanosomes in their tsetse fly vectors...
  34. ncbi Spatio-temporal distribution of tsetse and other biting flies in the Mouhoun River basin, Burkina Faso
    N Kone
    Centre International de Recherche Développement sur l Elevage en zone Subhumide, Bobo Dioulasso, Burkina Faso
    Med Vet Entomol 25:156-68. 2011
    ..The most frequent infection was Trypanosoma vivax (1.4%), followed by Trypanosoma congolense (0.3%) and Trypanosoma brucei (0.05%)...
  35. ncbi Cytokines in rats experimentally infected with Trypanosoma evansi
    Francine C Paim
    Laboratory of Veterinary Clinical Analysis LACVet, Federal University of Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Exp Parasitol 128:365-70. 2011
    ..TNF-α), interleukin 1 (IL-1) and interleukin 6 (IL-6) in the serum of rats experimentally infected with Trypanosoma evansi and to correlate these levels with hematological parameters...
  36. pmc Characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the Luangwa Valley, Zambia
    Neil E Anderson
    Centre for Infectious Diseases, Division of Pathway Medicine, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e1211. 2011
    ..The objective of this study was to characterise the nature of the reservoir community for trypanosomiasis in the absence of influence from domesticated hosts...
  37. ncbi Trypanosoma rangeli: RAPD-PCR and LSSP-PCR analyses of isolates from southeast Brazil and Colombia and their relation with KPI minicircles
    D S Marquez
    Departamento de Ciencias Biologicas, Universidade Federal do Triangulo Mineiro, Avenida Frei Paulino, 30, Uberaba, Minas Gerais CEP 38025 180, Brazil
    Exp Parasitol 117:35-42. 2007
    This study presents the first genetic characterization of five Trypanosoma rangeli isolates from Minas Gerais, in the southeast of Brazil and their comparison with Colombian populations by minicircle classification, RAPD-PCR and LSSP-PCR ..
  38. ncbi Phylogeny of Trypanosoma ( Megatrypanum ) theileri and related trypanosomes reveals lineages of isolates associated with artiodactyl hosts diverging on SSU and ITS ribosomal sequences
    A C Rodrigues
    Department of Parasitology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Parasitology 132:215-24. 2006
    ..Moreover, positioning of trypanosomes infecting tabanids in the T. theileri clade is consistent with the role of these flies as important vectors of these trypanosomes...
  39. ncbi Penetration of the salivary glands of Rhodnius domesticus Neiva & Pinto, 1923 (Hemiptera: Reduviidae) by Trypanosoma rangeli Tejera, 1920 (Protozoa: Kinetoplastida)
    Rosane M S Meirelles
    Laboratório de Biologia Celular de Microrganismos, Departamento de Ultra estrutura e Biologia Celular, Instituto Oswaldo Cruz FIOCRUZ, Avenida Brasil 4365, Manguinhos, 21040 900 Rio de Janeiro, RJ, Brazil
    Parasitol Res 97:259-69. 2005
    Penetration of the heteroxenous protozoan Trypanosoma rangeli into the salivary glands of its invertebrate host Rhodnius domesticus has been investigated here using different approaches...
  40. ncbi Evolutionary insights from bat trypanosomes: morphological, developmental and phylogenetic evidence of a new species, Trypanosoma (Schizotrypanum) erneyi sp. nov., in African bats closely related to Trypanosoma (Schizotrypanum) cruzi and allied species
    Luciana Lima
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Protist 163:856-72. 2012
    Parasites of the genus Trypanosoma are common in bats and those of the subgenus Schizotrypanum are restricted to bats throughout the world, with the exception of Trypanosoma (Schizotrypanum) cruzi that also infects other mammals and is ..
  41. ncbi Ecto-phosphatase activity on the external surface of Rhodnius prolixus salivary glands: modulation by carbohydrates and Trypanosoma rangeli
    Suzete A O Gomes
    Setor de Morfologia, Ultraetrutura e Bioquímica de Artrópodes e Parasitos, Laboratório de Transmissores de Leishmaniose Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 22045900, Brazil
    Acta Trop 106:137-42. 2008
    ..Rhodnius prolixus an important vector of Trypanosoma cruzi can also transmit Trypanosoma rangeli by bite...
  42. ncbi Multilocus phylogeographical analysis of Trypanosoma (Megatrypanum) genotypes from sympatric cattle and water buffalo populations supports evolutionary host constraint and close phylogenetic relationships with genotypes found in other ruminants
    Herakles A Garcia
    Departamento de Parasitologia, Universidade de Sao Paulo, Instituto de Ciencias Biomedicas II, Av Prof Lineu Prestes 1374, 05508 900 Sao Paulo, SP, Brazil
    Int J Parasitol 41:1385-96. 2011
    Species of the subgenus Trypanosoma (Megatrypanum) have been reported in cattle and other domestic and wild ruminants worldwide...
  43. pmc Multiple Trypanosoma infections are common amongst Glossina species in the new farming areas of Rufiji district, Tanzania
    Imna I Malele
    Tsetse and Trypanosomiasis Research Institute TTRI, Box 1026 Tanga, Tanzania
    Parasit Vectors 4:217. 2011
    ..Over the years Rufiji District was excluded from livestock production owing to tsetse fly infestation, however, a few years ago there was an influx of livestock following evictions aimed at conserving the Usangu wetlands...
  44. pmc Vaccination against trypanosomiasis: can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?
    Florencia La Greca
    Laboratory for Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Vaccin 7:1225-33. 2011
    ....
  45. ncbi A new species of trypanosome, Trypanosoma desterrensis sp. n., isolated from South American bats
    E C Grisard
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, CA 90095 1747, USA
    Parasitology 127:265-71. 2003
    Trypanosomes isolated from South American bats include the human pathogen Trypanosoma cruzi. Other Trypanosoma spp...
  46. pmc Trypanosoma vivax, T. congolense "forest type" and T. simiae: prevalence in domestic animals of sleeping sickness foci of Cameroon
    H Nimpaye
    Laboratoire de Biologie Générale, Département de Biologie et Physiologie Animales, Faculte des Sciences, Universite de Yaounde I, BP 812, Yaounde, Cameroun
    Parasite 18:171-9. 2011
    ..trypanosomiasis that occur together in sleeping sickness foci, a study of prevalences of animal parasites (Trypanosoma vivax, T. congolense "forest type", and T...
  47. ncbi Comparative phylogeography of Trypanosoma rangeli and Rhodnius (Hemiptera: Reduviidae) supports a long coexistence of parasite lineages and their sympatric vectors
    F Maia da Silva
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Mol Ecol 16:3361-73. 2007
    To make reliable interpretations about evolutionary relationships between Trypanosoma rangeli lineages and their insect vectors (triatomine bugs of the genus Rhodnius) and, thus, about the determinant factors of lineage segregation ..
  48. ncbi Prevalence and source of trypanosome infections in field-captured vector flies (Glossina pallidipes) in southeastern Zambia
    Hirohisa Mekata
    Department of Disease Control, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 70:923-8. 2008
    ..pallidipes, 58 (10.5%) flies were found to harbor trypanosome DNA. Infection rates of tsetse with Trypanosoma vivax universal, Trypanosoma congolense savannah, T. congolense forest and T. congolense kilifi were 4...
  49. ncbi Preventing and containing trypanocide resistance in the cotton zone of West Africa
    P H Clausen
    Institute for Parasitology and Tropical Veterinary Medicine, Freie Universitaet Berlin, Berlin, Germany
    Transbound Emerg Dis 57:28-32. 2010
    ..Engagement was initiated with actors involved in the problem of resistance and for its solution, including manufacturers, sellers and users of drugs, regulators and extension providers...
  50. ncbi Eco-epidemiological aspects of Trypanosoma cruzi, Trypanosoma rangeli and their vector (Rhodnius pallescens) in Panama
    Ana Maria de Vasquez
    Instituto Conmemorativo Gorgas de Estudios de la Salud ICGES, Panama, Republic of Panama
    Rev Inst Med Trop Sao Paulo 46:217-22. 2004
    ..However, the area is an imminent risk of infection for its population, consequently it is important to implement a community educational program regarding disease knowledge and control measures...
  51. ncbi Schizotrypanum in British bats
    R A Gardner
    Department of Biological Sciences, University of Salford
    Parasitology 97:43-50. 1988
    ..d. dionisii was found to have cyst-like structures in thoracic skeletal muscle containing amastigotes. The study provided the strongest evidence yet that C. pipistrelli is the vector of Schizotrypanum in British bats...
  52. ncbi Differential contribution of neutrophilic granulocytes and macrophages to nitrosative stress in a host-parasite animal model
    Maria Forlenza
    Department of Animal Sciences, Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, P O Box 338, 6700 AH Wageningen, The Netherlands
    Mol Immunol 45:3178-89. 2008
    ..The potential of T. borreli to serve as an alternative tool for pharmacological studies on human anti-trypanosome drugs is discussed...
  53. ncbi Evaluation of loop-mediated isothermal amplification (LAMP), PCR and parasitological tests for detection of Trypanosoma evansi in experimentally infected pigs
    Oriel M M Thekisoe
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 130:327-30. 2005
    Six surra negative piglets (6-week-old) were infected with Trypanosoma evansi and two uninfected piglets were used as negative controls...
  54. ncbi A new lineage of trypanosomes from Australian vertebrates and terrestrial bloodsucking leeches (Haemadipsidae)
    P B Hamilton
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Int J Parasitol 35:431-43. 2005
    ..and PCR-based methods using primers specific to the small subunit ribosomal RNA (SSU rRNA) gene of genus Trypanosoma. Trypanosome isolates were obtained in culture from two common wombats, one swamp wallaby and an Australian ..
  55. ncbi Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm
    Benoit Stijlemans
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    J Biol Chem 279:1256-61. 2004
    ..This was illustrated by the specific trypanolysis induced by an antibody::beta-lactamase fusion activating a prodrug...
  56. pmc Factors associated with acquisition of human infective and animal infective trypanosome infections in domestic livestock in Western Kenya
    Beatrix von Wissmann
    Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e941. 2011
    ..Busia District also remains endemic for human sleeping sickness with sporadic cases of sleeping sickness reported...
  57. ncbi Prevalence of Trypanosoma evansi infection and associated risk factors in camels in eastern Chad
    Arnaud Delafosse
    Laboratoire de Recherches Vétérinaires et Zootechniques de Farcha, BP 433, N Djamena, Chad
    Vet Parasitol 119:155-64. 2004
    A cross-sectional study was conducted to estimate the prevalence of Trypanosoma evansi infection (Surra) in herds of camels from the eastern area of Chad. The risk factors associated with disease were also identified...
  58. ncbi Development and application of a quantitative real-time PCR for the diagnosis of Surra in water buffaloes
    Satoru Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Infect Genet Evol 9:449-52. 2009
    b>Trypanosoma evansi (T. evansi) causes the disease called Surra in domestic animals, which is of great economic importance in South Asian countries...
  59. ncbi Camel trypanosomosis in the Canary Islands: assessment of seroprevalence and infection rates using the card agglutination test (CATT/T. evansi) and parasite detection tests
    C Gutierrez
    Department of Veterinary Internal Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
    Vet Parasitol 90:155-9. 2000
    Trypanosomosis due to Trypanosoma evansi (surra) is a major enzootic disease of the dromedary camel...
  60. ncbi Tripartite interactions between tsetse flies, Sodalis glossinidius and trypanosomes--an epidemiological approach in two historical human African trypanosomiasis foci in Cameroon
    Oumarou Farikou
    University of Yaounde I, Faculty of Science, BP 812, Yaounde, Cameroon
    Infect Genet Evol 10:115-21. 2010
    ..This hypothesis was statistically tested and assessed, showing that S. glossinidius is potentially an efficient target for controlling tsetse fly vectorial competence and consequently sleeping sickness...
  61. ncbi The flagellum of trypanosomes
    Linda Kohl
    INSERM U565, CNRS UMR5153, and MNHN USM 0503, Museum national d histoire naturelle, 75231 Paris, France
    Int Rev Cytol 244:227-85. 2005
    ..The most striking phenomenon is the involvement of the flagellum in several aspects of the trypanosome cell cycle, including cell morphogenesis, basal body migration, and cytokinesis...
  62. ncbi Role of superoxide and reactive nitrogen intermediates in Rhodnius prolixus (Reduviidae)/Trypanosoma rangeli interactions
    M M Whitten
    Biomedical and Physiological Research Group, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, SA2 8PP, United Kingdom
    Exp Parasitol 98:44-57. 2001
    ..nitric oxide and prophenoloxidase pathways in Rhodnius prolixus hemolymph, measured in parallel, in response to Trypanosoma rangeli inoculation. Responses to two strains of T...
  63. ncbi Identification of trypanosomes in wild animals from southern Cameroon using the polymerase chain reaction (PCR)
    S Herder
    LRCT IRD CIRAD, TA 207 G, Campus International de Baillarguet, F 34398 Montpellier, France
    Parasite 9:345-9. 2002
    ..monticola), in carnivores (Nandinia binotata and Genetta servalina) and in rodents (Cricetomys gambianus and Atherurus africanus). 13 species (54%) were carrying T. brucei s.l. identified as non-gambiense group 1...
  64. pmc Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model
    Maria Pilar Molina-Portela
    Department of Medical Parasitology, New York University Langone Medical Center School of Medicine, New York, NY 10010, USA
    J Exp Med 205:1721-8. 2008
    ..a unique subset of high-density lipoproteins (HDLs) called trypanosome lytic factors (TLFs) that kill many Trypanosoma parasite species...
  65. ncbi Polymerase chain reaction as a diagnosis tool for detecting trypanosomes in naturally infected cattle in Burkina Faso
    P Solano
    CIRAD EMVT campus de Baillarguet, Montpellier, France
    Vet Parasitol 86:95-103. 1999
    ..The PCR was applied on a subset of 260 buffy-coat samples using primers specific for Trypanosoma congolense savannah and riverine-forest groups, T. vivax, and T. brucei...
  66. ncbi Natural and induced dyskinetoplastic trypanosomatids: how to live without mitochondrial DNA
    Achim Schnaufer
    Seattle Biomedical Research Institute, 4 Nickerson Street, Suite 200, Seattle, WA 98109, USA
    Int J Parasitol 32:1071-84. 2002
    ..The most infamous parasites of this group are the African subspecies of the Trypanosoma brucei group, which cause sleeping sickness in humans and nagana in cattle...
  67. ncbi The cytoskeleton of trypanosomatid parasites
    K Gull
    School of Biological Sciences, University of Manchester, United Kingdom
    Annu Rev Microbiol 53:629-55. 1999
    Species of the trypanosomatid parasite genera Trypanosoma and Leishmania exhibit a particular range of cell shapes that are defined by their internal cytoskeletons...
  68. ncbi Towards an understanding of the interactions of Trypanosoma cruzi and Trypanosoma rangeli within the reduviid insect host Rhodnius prolixus
    Patricia Azambuja
    Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Rio de Janeiro, RJ 21045 900, Brazil
    An Acad Bras Cienc 77:397-404. 2005
    This review outlines aspects on the developmental stages of Trypanosoma cruzi and Trypanosoma rangeli in the invertebrate host, Rhodnius prolixus...
  69. ncbi Trypanosoma brucei infection induces apoptosis and up-regulates neuroleukin expression in the cerebellum
    J K Stiles
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA 30310 1495, USA
    Ann Trop Med Parasitol 95:797-810. 2001
    Human infection with Trypanosoma brucei may result in meningo-encephalitis, neuronal demyelination, blood-brain-barrier dysfunction, peri-vascular infiltration, astrocytosis and neuronal apoptosis...
  70. ncbi Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers
    N Biteau
    Laboratoire de Parasitologie Moleculaire, université Victor Segalen de Bordeaux II, UPRESA 5016 CNRS, France
    Mol Biochem Parasitol 105:185-201. 2000
    ..Here we analyse a repeated DNA coding sequence and eleven new microsatellites identified within the Trypanosoma (Trypanozoon) brucei genome...
  71. ncbi Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite
    J D Barry
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Scotland, UK
    Adv Parasitol 49:1-70. 2001
    ....
  72. ncbi Expression of fluorescent genes in Trypanosoma cruzi and Trypanosoma rangeli (Kinetoplastida: Trypanosomatidae): its application to parasite-vector biology
    Palmira Guevara
    Instituto de Biologia Experimental, Universidad Central de Venezuela, Caracas 1041A, Venezuela
    J Med Entomol 42:48-56. 2005
    Two Trypanosoma cruzi-derived cloning vectors, pTREX-n and pBs:CalB1/CUB01, were used to drive the expression of green fluorescent protein (GFP) and DsRed in Trypanosoma rangeli Tejera, 1920, and Trypanosoma cruzi Chagas, 1909, isolates, ..
  73. ncbi Transcription of signal-3 cytokines, IL-12 and IFN alpha beta, coincides with the timing of CD8 alpha beta up-regulation during viral infection of common carp (Cyprinus carpio L)
    Maria Forlenza
    Department of Animal Sciences, Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, PO Box 338, 6700 AH, Wageningen, The Netherlands
    Mol Immunol 45:1531-47. 2008
    ..The relevance of our findings to future vaccination strategies in fish is discussed...
  74. ncbi Parasite-specific trypanothione reductase as a drug target molecule
    R Luise Krauth-Siegel
    Biochemie Zentrum Heidelberg, Universitat Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany
    Parasitol Res 90:S77-85. 2003
    ..The (dis)advantages of the different types of compounds as potential drug candidates as well as modern computer-based approaches to the identification of new leads are discussed...
  75. pmc Activity of trypanosome lytic factor: a novel component of innate immunity
    Russell Thomson
    Medical Parasitology, New York University Langone Medical Center, 341 East 25th Street, New York, NY 10010, USA
    Future Microbiol 4:789-96. 2009
    ..TLFs are characterized by their ability to kill extracellular protozoon parasites of the genus Trypanosoma. Two subspecies of Trypanosoma brucei have evolved resistance to TLFs and can consequently infect humans, ..
  76. pmc Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor
    Karen McLuskey
    Westchem School of Chemistry, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom
    J Biol Chem 285:39249-59. 2010
    ..It could facilitate the development of specific OPB inhibitors with therapeutic potential by exploiting its unique substrate recognition properties as well as providing a model for OPBs in general...
  77. ncbi Phylogenetic analyses based on small subunit rRNA and glycosomal glyceraldehyde-3-phosphate dehydrogenase genes and ultrastructural characterization of two snake Trypanosomes: Trypanosoma serpentis n. sp. from Pseudoboa nigra and Trypanosoma cascavelli fr
    Laerte B Viola
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    J Eukaryot Microbiol 56:594-602. 2009
    ..The isolate from P. nigra is described as a new species, Trypanosoma serpentis n. sp., whereas the isolate from C. d. terrificus is redescribed here as Trypanosoma cascavelli.
  78. ncbi Unravelling the phylogenetic relationships of African trypanosomes of suids
    W C Gibson
    School of Biological Sciences, University of Bristol, UK
    Parasitology 122:625-31. 2001
    ..Neither the recently described Trypanosoma (Nannomonas) godfreyi nor Trypanosoma (Nannomonas) congolense Tsavo have been isolated from mammalian hosts, ..
  79. ncbi [Eco-distribution and Trypanosoma infection of Glossina palpalis palpalis in the Banco forest of and its relics, Abidjan (Côte d'Ivoire)]
    K Allou
    Université d Abidjan Cocody, Laboratoire de Zoologie, 22 BP 582, Abidjan 22, Cote d Ivoire
    Parasite 16:289-95. 2009
    ..One species of tsetse fly (Glossina polpalis palpalis) and two species of trypanosomes (Trypanosoma congolense, T. vivax) have been revealed...
  80. ncbi Patterns of co-evolution between trypanosomes and their hosts deduced from ribosomal RNA and protein-coding gene phylogenies
    Patrick B Hamilton
    School of Biosciences, University of Exeter, Exeter, UK
    Mol Phylogenet Evol 44:15-25. 2007
    Trypanosomes (genus Trypanosoma) are widespread blood parasites of vertebrates, usually transmitted by arthropod or leech vectors...
  81. ncbi Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
    Cedric S Graebin
    Lab de Síntese Orgânica Medicinal LaSOM, Faculdade de Farmacia, UFRGS, Avenida Ipiranga, 2752, sala 705, 90610 000 Porto Alegre, RS, Brazil
    Eur J Med Chem 45:1524-8. 2010
    The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V...
  82. ncbi Infection rates and genotypes of Trypanosoma rangeli and T. cruzi infecting free-ranging Saguinus bicolor (Callitrichidae), a critically endangered primate of the Amazon Rainforest
    F Maia da Silva
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo USP, Sao Paulo, SP, Brazil
    Acta Trop 107:168-73. 2008
    ..In the Amazon region, non-human primates are commonly infected by Trypanosoma cruzi and T. rangeli, which are also infective to man and several mammals...
  83. ncbi Inside and outside of the trypanosome flagellum:a multifunctional organelle
    P Bastin
    Department of Biochemistry, School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Microbes Infect 2:1865-74. 2000
    ..This is the case of the flagellum, containing conventional and unique structures whose role in infectivity is still enigmatic...
  84. ncbi [Trypanosoma rangeli parasite-vector-vertebrate interactions and their relationship to the systematics and epidemiology of American trypanosomiasis]
    Gustavo Adolfo Vallejo
    Laboratorio de Investigaciones en Parasitología Tropical, Facultad de Ciencias, Universidad del Tolima, Ibague, Colombia
    Biomedica 27:110-8. 2007
    b>Trypanosoma rangeli is a species of trypanosome second to T. cruzi, that is infective to humans in Latin America...
  85. ncbi Blood parasites of chickens in Uganda and Cameroon with molecular descriptions of Leucocytozoon schoutedeni and Trypanosoma gallinarum
    Ravinder N M Sehgal
    Department of Biology, San Francisco State University, 1600 Holloway Ave, San Francisco, California 94132, USA
    J Parasitol 92:1336-43. 2006
    ..3% were infected with Leucocytozoon schoutedeni (Haemosporida, Leucocytozoidae) and 4.1% were infected with Trypanosoma gallinarum (Kinetoplastida, Trypanosomatidae). No other blood parasites were detected...
  86. ncbi Molecular characterization of the kinetoplastid membrane protein-11 genes from the parasite Trypanosoma rangeli
    H Diez
    Laboratorio de Parasitologia Molecular, Departamento de Microbiologia, Facultad Ciencias, Pontificia Universidad Javeriana, Carrera 7a No 43 82, Edificio 50, Laboratorio 113, Bogota, Colombia
    Parasitology 130:643-51. 2005
    Trypanosomatids are early divergent parasites which include several species of medical interest. Trypanosoma rangeli is not pathogenic for humans but shows a high immunological cross-reactivity with Trypanosoma cruzi, the causative agent ..
  87. ncbi Preliminary characterization of a Rhodnius prolixus hemolymph trypanolytic protein, this being a determinant of Trypanosoma rangeli KP1(+) and KP1(-) subpopulations' vectorial ability
    Ximena Carolina Pulido
    Laboratorio de Investigaciones en Parasitología Tropical, Facultad de Ciencias, Universidad del Tolima, Ibague, Colombia
    Mem Inst Oswaldo Cruz 103:172-9. 2008
    Rhodnius prolixus is the main Trypanosoma rangeli vector in several Latin-American countries and is susceptible to infection with KP1(+) strains; however, it presents an invasion-resistant response to KP1(-) strains...
  88. ncbi Trypanosoma (Herpetosoma) kuseli sp. n. (Protozoa: Kinetoplastida) in Siberian flying squirrels (Pteromys volans)
    H Sato
    Faculty of Agriculture, Laboratory of Veterinary Parasitology, Yamaguchi University, 1677 1 Yoshida, Yamaguchi, 753 8515, Japan
    Parasitol Res 101:453-61. 2007
    ..We describe in this paper a novel trypanosome species, Trypanosoma (Herpetosoma) kuseli sp. n...
  89. ncbi Phylogeny, taxonomy and grouping of Trypanosoma rangeli isolates from man, triatomines and sylvatic mammals from widespread geographical origin based on SSU and ITS ribosomal sequences
    F Maia Da Silva
    Department of Parasitology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Parasitology 129:549-61. 2004
    Phylogenetic relationships among Trypanosoma rangeli isolates from man, wild mammals and triatomine bugs from widespread geographical origin were inferred by comparison of the small subunit of ribosomal gene sequences...
  90. ncbi Structure and sequence variation of the trypanosome spliced leader transcript
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol, UK
    Mol Biochem Parasitol 107:269-77. 2000
    ..of using the spliced leader (SL) or mini-exon gene as a marker for molecular phylogenetic analysis of genus Trypanosoma. A total of 27 trypanosome sequences were compared, 18 of these being newly reported...
  91. ncbi Induction and regulation of Trypanosoma brucei VSG-specific antibody responses
    S J Black
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Parasitology 137:2041-9. 2010
    The review addresses how infection with Trypanosoma brucei affects the development, survival and functions of B lymphocytes in mice...
  92. ncbi Susceptibility of Trypanosoma evansi to human blood and plasma in infected mice
    Mateus Anderson Otto
    Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Camobi, Prédio 20, Sala 4232, CEP 97105900, Santa Maria, RS, Brazil
    Vet Parasitol 168:1-4. 2010
    ..Besides the longer longevity, treatments were capable of curing 50% of mice of group B, 37.5% of group C, 37.5% of group D and 25% of the animals from group E...
  93. pmc An outbreak of bovine trypanosomiasis in the Blue Nile State, Sudan
    Bashir Salim
    Department of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Parasit Vectors 4:74. 2011
    ..of bovine trypanosomiasis in Kurmuk District, Blue Nile State, Sudan that involved an infection with four Trypanosoma species in cattle...
  94. ncbi Apicomplexa, trypanosoma and parasitic nematode protein kinases as antiparasitic therapeutic targets
    Fina Liotta
    Montclair State University, Sokol Institute of Pharmaceutical Life Sciences and Department of Chemistry and Biochemistry, 1 Normal Avenue, Montclair, NJ 07043, USA
    Curr Opin Investig Drugs 11:147-56. 2010
    Parasitic infections caused by Plasmodium, Trypanosoma, Leishmania, Toxoplasma and parasitic nematodes affect hundreds of millions of individuals worldwide and are the cause of significant mortality and morbidity, particularly in ..
  95. ncbi Phylogenetic position of the kinetoplastids, Cryptobia bullocki, Cryptobia catostomi, and Cryptobia salmositica and monophyly of the genus Trypanosoma inferred from small subunit ribosomal RNA sequences
    A D Wright
    Department of Zoology, University of Guelph, Ont, Canada
    Mol Biochem Parasitol 99:69-76. 1999
    ..Within the trypanosomatid clade, the genus Trypanosoma is a monophyletic group that divides into two groups, the salivarian trypanosomes and the stercorarian ..
  96. ncbi Genetic relatedness among Trypanosoma evansi stocks by random amplification of polymorphic DNA and evaluation of a synapomorphic DNA fragment for species-specific diagnosis
    R M Ventura
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Prof Lineu Prestes, 1374, 05508 900, Sao Paulo, SP, Brazil
    Int J Parasitol 32:53-63. 2002
    ..we employed randomly amplified polymorphic DNA patterns to assess the genetic relatedness among 14 Brazilian Trypanosoma evansi stocks from domestic and wild hosts, which are known to differ in biological characteristics...
  97. ncbi Parasitemia in a neonatal bison calf
    Anne Lanevschi-Pietersma
    Départements de Pathologie et Microbiologie, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, PQ, Canada
    Vet Clin Pathol 33:173-6. 2004
    ..The organisms ranged in length from 35 to 40 micro meter, excluding the flagellum, and were identified as Trypanosoma theileri...
  98. ncbi Unique behavior of Trypanosoma dionisii interacting with mammalian cells: invasion, intracellular growth, and nuclear localization
    Miriam Pires de Castro Oliveira
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Rua Botucatu 862, Sao Paulo, Brazil
    Acta Trop 110:65-74. 2009
    The phylogenetic proximity between Trypanosoma cruzi and Trypanosoma (Schizotrypanum) dionisii suggests that these parasites might explore similar strategies to complete their life cycles. T...
  99. pmc Population genetics of Trypanosoma evansi from camel in the Sudan
    Bashir Salim
    Department of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    PLoS Negl Trop Dis 5:e1196. 2011
    ..brucei brucei. Though the first hypothesis is the most likely, discriminating between these two incompatible hypotheses will require further studies at much localized scales...
  100. ncbi Short report: Human trypanosomiasis caused by Trypanosoma evansi in a village in India: preliminary serologic survey of the local population
    Vijay R Shegokar
    Department of Microbiology, Government Medical College, Nagpur, India
    Am J Trop Med Hyg 75:869-70. 2006
    After discovery of the first recorded case of human infection with Trypanosoma evansi, serologic screening of 1,806 persons from the village of origin of the patient in India was performed using the card agglutination test for ..
  101. ncbi Trypanosoma rangeli: Differential expression of cell surface polypeptides and ecto-phosphatase activity in short and long epimastigote forms
    Suzete A O Gomes
    Laboratório de Bioquímica Celular, Instituto de Bioquímica Médica IBqM, Bloco H, Centro de Ciencias da Saude CCS, Universidade Federal do Rio de Janeiro UFRJ, Av Brigadeiro Trompowsky s n, Ilha do Fundao, Rio de Janeiro, RJ 21941 590, Brazil
    Exp Parasitol 112:253-62. 2006
    b>Trypanosoma rangeli is a parasite of a numerous wild and domestic animals, presenting wide geographical distribution and high immunological cross-reactivity with Trypanosoma cruzi, which may lead to misdiagnosis. T...

Research Grants71

  1. International Symposium on Proline Metabolism and Human Health
    Donald F Becker; Fiscal Year: 2010
    ..g., Trypanosoma brucei, African sleeping sickness) and pathogenic bacteria (e.g...
  2. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
  3. Pathogenesis of Oxidative Stress in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease is caused by the protozoan Trypanosoma cruzi, and represents the third greatest tropical disease burden globally...
  4. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease, caused by an intracellular parasite Trypanosoma cruzi, is a major public health problem with significant social and economic implications in most Latin American countries and among ..
  5. Mitochondrial Biomarkers of Cardiomyopathy and Cure in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagasic cardiomyopathy (CCM) is caused by the protozoan Trypanosoma cruzi, and represents the third greatest tropical disease burden globally...
  6. The role of polyphosphate and acidocalcisomes in Trypanosoma brucei
    Roberto Docampo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei is the causative agent of sleeping sickness or African trypanosomiasis...
  7. RNA polymerase II transcription in trypanosomes
    ARTHUR GUNZL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The trypanosomatid parasites Trypanosoma brucei, T. cruzi and Leishmania spp. cause the major human diseases African Sleeping Sickness, Chagas'disease, and Leishmaniasis, respectively...
  8. Cytosine DNA Methylation and Transcriptional Repression in African Trypanosomes
    KEVIN MILITELLO; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Trypanosoma brucei is the protozoan parasite responsible for Human African Trypanosomiasis (HAT), otherwise known as African Sleeping Sickness...
  9. Function of mRNA Editing in Trypanosomes
    Stephen L Hajduk; Fiscal Year: 2010
    ..focused on the mRNA for cytochrome c oxidase III (COIII), which we discovered was alternatively edited in Trypanosoma brucei...
  10. Rational Development of Anti-Trypanosoma Cruzi Drugs
    Michael H Gelb; Fiscal Year: 2013
    ..b>Trypanosoma cruzi, the etiologic agent of Chagas disease, is widespread in Latin America and causes cardiomyopathy and ..
  11. International Workshop on Opportunistic Protists (IWOP-12, 13 and 14)
    Louis M Weiss; Fiscal Year: 2012
    ..of other neglected pathogens in AIDS patients including the kinetoplastid flagellates Leishmania and Trypanosoma cruzi...
  12. K777 for treatment of Chagas Disease: IND-enabling Studies and IND Submission
    Robert Don; Fiscal Year: 2012
    ..cysteine protease inhibitor which irreversibly inhibits cruzain, a key protease required for viability of Trypanosoma cruzi, the parasite responsible for Chagas disease...
  13. The Lysosome of Trypanosoma brucei: A Proteomic Analysis
    James D Bangs; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): African trypanosomes (Trypanosoma brucei ssp.) are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness) and nagana in livestock...
  14. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
  15. Role of mucin-type O-glycosylation in Trypanosoma cruzi biology
    Christopher M West; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Trypanosoma cruzi is a single-cell protozoan parasite that causes Chagas disease, characterized by cardiac or gastrointestinal complications in chronically infected patients...
  16. Regulation of a Novel Trypanosome RNA Binding Protein by Arginine Methylation
    Kaylen Lott; Fiscal Year: 2013
    ..Kinetoplastids, including Trypanosoma brucei, T. cruzi, and Leishmania spp...
  17. Olfactory and behavioral responses of kissing bugs (Reduviidae: Triatominae), vec
    John G Hildebrand; Fiscal Year: 2010
    ..known as kissing bugs, vinchuca, chipo, barbeiro, are blood-sucking insects, vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas Disease...
  18. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans...
  19. Geographically robust rapid assay for T. cruzi infection
    SYAMAL X RAYCHAUDHURI; Fiscal Year: 2010
    ..is to develop a standardized and FDA cleared rapid serodiagnostic and confirmatory test for detection of Trypanosoma cruzi (T. cruzi) infections. T...
  20. Synthesis of immunogenic glycolipopeptides for the development of vaccines for Ch
    Katja Michael; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in Central America...
  21. Chagas Disease Confirmatory Assay
    Andrew Levin; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chagas'Disease is a vector-borne parasitic infection of humans with Trypanosoma cruzi, which has recently been identified as an emerging and significant threat to transfusion safety and the ..
  22. Human serum carbonyl proteome in cardiovascular diseases
    Nisha Jain Garg; Fiscal Year: 2010
    Chagasic cardiomyopathy emerges in 30-40% of the patients infected by Trypanosoma cruzi, and accounts for >50,000 deaths and the loss of 2.74 million disability-adjusted life years per year...
  23. Confirmatory Immunoblot Test for Chagas'Disease
    ANDREW E LEVIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas'Disease is a vector-borne parasitic infection of humans with Trypanosoma cruzi, which has recently been identified as an emerging and significant threat to transfusion safety and the ..
  24. Reprogramming of the Trypanosoma brucei epigenome during human infection: opportu
    Hugh George Patterton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposal aims to study the reprogramming of the Trypanosoma brucei epigenome that accompanies movement of this trypanosome from the insect to the human host. T...
  25. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    CHING CHUNG WANG; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The parasitic protozoa, Trypanosoma brucei spp., are the causative pathogens of African sleeping sickness in humans and nagana in cattle...
  26. Validation and development of trypanosomal phosphodiesterase inhibitors for treat
    Michael P Pollastri; Fiscal Year: 2013
    ..In particular, since the genome for Trypanosoma brucei (the causative parasite for Human African Trypanosomiasis (HAT)) and T...
  27. Translational partitioning of the SL RNA
    David A Campbell; Fiscal Year: 2010
    ..Undermethylated substrate SL RNA is trafficked intracellularly prior to trans-splicing in Trypanosoma brucei and Leishmania tarentolae, introducing potential competitors into the cytosol for translation initiation ..
  28. Pathogenesis of Trypanosoma cruzi infection
    Roberto Docampo; Fiscal Year: 2013
    ..One of the most interesting characteristics of Trypanosoma cruzi, the etiologic agent of Chagas disease, is its possession of two closely associated organelles, the ..
  29. Global sumoylation analysis in Trypanosoma brucei
    David A Campbell; Fiscal Year: 2010
    ..The hypothesis underlying this application is that the stability, function, and localization of a few hundred Trypanosoma brucei proteins will be modified by covalent attachment with the ubiquitin-like protein modifier SUMO...
  30. Polyamine and trypanothione metabolism in Trypanosoma brucei
    Margaret A Phillips; Fiscal Year: 2013
    Human African trypanosomiasis (HAT) is caused by the parasitic protozoan, Trypanosoma brucei...
  31. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): African trypanosomes (Trypanosoma brucei ssp.) are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  32. REGULATION OF TRYPANOSOME DNA REPLICATION
    Dan S Ray; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei, the African trypanosome, is a protozoan parasite that causes sleeping sickness in humans and a similar disease in livestock...
  33. REGULATION OF TRYPANOSOME DNA REPLICATION
    DAN RAY; Fiscal Year: 2009
    ..addresses two related questions: (1) What are the molecular mechanisms that regulate S-phase gene expression in Trypanosoma brucei? and (2) How is the expression of a specific mitochondrial DNA ligase regulated during the cell cycle ..
  34. Characterization of Potassium Channels in the Human Parasite Trypanosoma Cruzi
    Veronica Jimenez; Fiscal Year: 2012
    ..provided by applicant): Chagas disease is a zoonotic tropical pathology, caused by the protozoan parasite Trypanosoma cruzi. Endemic in Latin America, it is one of the leading causes of congestive heart failure in the world...
  35. Cap binding and gene expression in trypanosomes
    David A Campbell; Fiscal Year: 2013
    ..Functional redundancy of the eIF4E5 and eIF4E6 orthologs will be tested in gene knockdown and knockouts in Trypanosoma brucei with the goal of determining the function of eIF4E5...
  36. Transcriptome profiling of Trypanosoma cruzi and its host cell
    Najib M El-Sayed; Fiscal Year: 2012
    ..In the present study, we focus on the kinetoplastid protozoan parasite Trypanosoma cruzi, the causative agent of human Chagas'disease...
  37. Deep sequence profiling of gRNA transcriptomes in two stages of Trypanosoma bruce
    DONNA JAY KOSLOWSKY; Fiscal Year: 2012
    ..deep sequencing technology to characterize the full gRNA transcriptomes in the two main life cycle stages of Trypanosoma brucei...
  38. Trypanosoma cruzi Antioxidant Systems, Virulence and Parasite Persistence in Chag
    Rafael Radi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease caused by the parasitic protozoan Trypanosoma cruzi remains a major public health concern in Latin America and is now spreading worldwide...
  39. Biochemical and Functional Analysis of Trypanin
    Kent L Hill; Fiscal Year: 2013
    ABSTRACT African trypanosomes (e.g. Trypanosoma brucei) are protozoan parasites that cause African sleeping sickness, a fatal disease with devastating health and economic impact...
  40. Location: Its role in protein-RNA contact during trypanosome gene regulation
    Vivian Bellofatto; Fiscal Year: 2013
    ..A particularly serious problem in sub-Saharan Africa is caused by Trypanosoma brucei, a parasite spread by the bite of an infected Tsetse fly. T...
  41. Early Detection of Congenital Chagas Disease
    Robert H Gilman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Twenty-six percent of new Trypanosoma cruzi infections occur through mother-to-child transmission, and as vector and blood donation control improve, the proportion attributable to congenital ..
  42. Regulation of cell division in Trypanosoma brucei
    Ziyin Li; Fiscal Year: 2011
    Project Summary The cell cycle control system in the protozoan parasite Trypanosoma brucei possesses many unusual features, among which mitosis and cytokinesis represent the most unusual aspects to be explored in more detail...
  43. Global gene expression analysis of Trypanosoma cruzi under hyperosmotic stress
    Roberto Docampo; Fiscal Year: 2012
    ..from Mexico in the North to Argentina and Chile in the South, there are 16 to 19 million people infected with Trypanosoma cruzi, the causative agent of Chagas disease. Estimated yearly incidence amounts to 561,000 cases...
  44. Parameters that govern initiation of VSG switching in T.brucei
    F Nina Papavasiliou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The parasitic protozoan Trypanosoma brucei is the causative agent of African trypanosomiasis which causes sleeping sickness in humans and Nagana in farm animals...
  45. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..However, the availability of sophisticated genetic strategies for manipulation of Trypanosoma brucei provides a potent system in which to study general cell biology...
  46. Structural Analysis of the GPI Transamidase Complex
    Anant K Menon; Fiscal Year: 2012
    ..include folate receptor, acetylcholinesterase, renal dipeptidase and the variant surface glycoproteins of Trypanosoma brucei, the causative agent of African sleeping sickness...
  47. Testing DNA Vaccine Against T. cruzi in Large Animal Model (Dogs)
    Nisha Jain Garg; Fiscal Year: 2010
    ..cruzi. Infection by Trypanosoma cruzi causes Chagasic cardiomyopathy in humans...
  48. Mechanistic and structural studies of eukaryotic UDP-galactopyranose mutases
    Pablo Sobrado; Fiscal Year: 2013
    ..fumigatus and Trypanosoma cruzi as prototypes from fungal and protozoan parasites, respectively...
  49. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    Ching Wang; Fiscal Year: 2009
    ..6. ti' IL' I.) PROJECT SUMMARY/ABSTRACT <c .-U. The parasitic protozoa, Trypanosoma brucei spp., are the causative pathogens of spp., African sleeping sickness in humans and nagana in cattle...
  50. Protein Arginine Methylation in Trypanosomes
    Laurie K Read; Fiscal Year: 2013
    ..In Trypanosoma brucei, gene regulation is largely effected posttranscriptionally, and thus likely involves a plethora of RNA ..
  51. Targeting Trypanosoma brucei S-adenosylmethionine decarboxylase in Drug Discovery
    NAHIR VELEZ; Fiscal Year: 2012
    Human African Trypanosomiasis (HAT), commonly called sleeping sickness, is caused by single-celled parasites, Trypanosoma brucei, which are transmitted to humans by infected tsetse flies...
  52. Characterization of Potassium Channels in the Human Parasite Trypanosoma Cruzi
    Veronica Jimenez; Fiscal Year: 2013
    Abstract Chagas disease is a zoonotic tropical pathology, caused by the protozoan parasite Trypanosoma cruzi. Endemic en Latin America, it is one of the leading causes of congestive heart failure in the world...
  53. Kinetoplastid SL RNA biogenesis
    David A Campbell; Fiscal Year: 2013
    ..outlines experiments that detail the maturation pathway of the SL RNA common to Leishmania tarentolae and Trypanosoma brucei at the level of individual proteins and interacting complexes, and probe the role of the SL in ..
  54. The Role of Trypanosome Calcium Signaling in Parasite Virulence and Transmission
    Brian T Emmer; Fiscal Year: 2010
    The long-term objective of this application is to understand the molecular mechanisms by which Trypanosoma cruzi and Trypanosoma brucei are able to survive within the mammalian host and cause such profound disease...
  55. RNA CAPPING IN TRYPANOSOMES
    Christian Tschudi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This application focuses on African trypanosomes of the Trypanosoma brucei subspecies, the causative agents of human African trypanosomiasis, a fatal disease unless treated, with a calculated disease ..
  56. Role of the guide RNA binding protein RBP16 in the bloodstream form of T. brucei
    John C Fisk; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The parasitic protozoan, Trypanosoma brucei, is the causative agent of sleeping sickness in humans and nagana in domestic livestock. Sleeping sickness is invariably fatal if left untreated...
  57. Biosynthesis and function of base J in T. brucei
    Robert S Sabatini; Fiscal Year: 2011
    African trypanosomes (Trypanosoma brucei) are protozoan parasites that cause a fatal disease known as African sleeping sickness in humans and related diseases in animals. These diseases have devastating health and economic consequences...
  58. Mechanisms of the Unusual Cytokinesis in Trypanosomes
    Ziyin Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cytokinesis in Trypanosoma brucei, a parasitic protozoan and the causative agent of human sleeping sickness, is known to be totally different from that in its human host...
  59. Small RNAs and their role in trypanosome biology
    Elisabetta Ullu; Fiscal Year: 2012
    ..Many laboratories, including our own, have been engaged in studying the biology of Trypanosoma brucei and have contributed to the understanding of several mechanisms that are unique to trypanosomes...
  60. Guide RNA Binding Complex
    RUSLAN AFASIZHEV; Fiscal Year: 2013
    ..The causative agent of African sleeping sickness, Trypanosoma brucei, is also an important model organism for several areas of research, including antigenic variation, host-..
  61. Protein Arginine Methylation in Trypanosomes
    LAURIE READ; Fiscal Year: 2009
    ..In Trypanosoma brucei, gene regulation is largely effected posttranscriptionally, and thus likely involves a plethora of RNA ..
  62. A novel vacuolar compartment in Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2010
    ..AQP), a property that it shares with the plant cell vacuole and the contractile vacuole and acidocalcisomes of Trypanosoma cruzi. Our hypotheses are that: (1) the T...
  63. Sterol Biosynthesis in Trypanosomatid Parasites
    Frederick Buckner; Fiscal Year: 2004
    ..is fatal if untreated and cutaneous leishmaniasis causes serious morbidity, Chagas disease is caused by Trypanosoma cruzi and is endemic in over 20 countries in Latin America...
  64. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant) [unreadable] Chagas' disease, caused by Trypanosoma cruzi, is an important cause of heart disease in Brazil...
  65. ANALYSIS OF THE TRYPANOSOMA BRUCEI GENOME USING TILING ARRAYS
    Christian Tschudi; Fiscal Year: 2009
    ..The completion of the genomes of three trypanosomatids, namely Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, has opened insights into the coding potential and evolution of ..
  66. MUTATIONAL ANALYSIS OF A PARASITE PURINE SALVAGE ENZYME
    SYDNEY CRAIG; Fiscal Year: 2001
    ..The enzyme that is the subject of this study is the hypoxanthine phosphoribosyltransferase (HPRT) of Trypanosoma cruzi, etiologic agent of Chagas' disease...
  67. MITOCHONDRIAL RNA EDITING IN TRYPANOSOMA BRUCEI
    DONNA KOSLOWSKY; Fiscal Year: 1999
    ..In Trypanosoma brucei, there is a transcript specific mechanism that regulates editing during the life cycle of the parasite...
  68. TRYPANASOMA CRUZI GENOME-SBRI
    Kenneth Stuart; Fiscal Year: 2004
    We propose to sequence the genome of Trypanosoma cruzi, a human pathogen of global importance, as part of an interactive research project...
  69. Origin of Virulence Factors in African Trypanosomes
    ANDREW MCARTHUR; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are protozoan parasites that cause African sleeping sickness in humans while Trypanosoma brucei brucei causes a wasting disease in ..
  70. Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesis
    Samuel Black; Fiscal Year: 2009
    ..hypothesis in the following specific aims: i) identify the stage at which B lineage development is arrested in Trypanosoma brucei-infected mice ii) determine whether the block in B cell development results from truncated or aberrant B ..
  71. ACIDOCALCISOMES IN TRYPANOSOMA CRUZI
    Roberto Docampo; Fiscal Year: 2002
    ..from Mexico in the North to Argentina and Chile in the South, there are 16 to 19 million people infected with Trypanosoma cruzi, the causative agent of Chagas' disease...