trypanosoma brucei rhodesiense

Summary

Summary: A hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans. It is carried by Glossina pallidipes, G. morsitans and occasionally other species of game-attacking tsetse flies.

Top Publications

  1. pmc Options for field diagnosis of human african trypanosomiasis
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Clin Microbiol Rev 18:133-46. 2005
  2. pmc The burden of human African trypanosomiasis
    Eric M Fèvre
    Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 2:e333. 2008
  3. ncbi Intrathecal cytokine responses in Trypanosoma brucei rhodesiense sleeping sickness patients
    Lorna MacLean
    Department of Zoology, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Trans R Soc Trop Med Hyg 100:270-5. 2006
  4. ncbi Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
  5. pmc New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289
    Tanja Wenzler
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Antimicrob Agents Chemother 53:4185-92. 2009
  6. ncbi Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys
    M Ngotho
    Institute of Primate Research, Karen, Nairobi, Kenya
    Trop Med Int Health 14:736-47. 2009
  7. pmc Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania
    Harriet K Auty
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    PLoS Negl Trop Dis 6:e1501. 2012
  8. pmc Focus-specific clinical profiles in human African Trypanosomiasis caused by Trypanosoma brucei rhodesiense
    Lorna M MacLean
    Department of Biology, Hull York Medical School, Centre for Immunology and Infection, University of York, York, United Kingdom
    PLoS Negl Trop Dis 4:e906. 2010
  9. ncbi A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence
    Jeremy M Sternberg
    Institute of Biological and Environmental Sciences, University of Aberdeen, Zoology Building, Aberdeen AB242TZ, UK
    Parasitology 137:2007-15. 2010
  10. pmc Eliminating human African trypanosomiasis: where do we stand and what comes next?
    Pere P Simarro
    World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland
    PLoS Med 5:e55. 2008

Detail Information

Publications205 found, 100 shown here

  1. pmc Options for field diagnosis of human african trypanosomiasis
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Clin Microbiol Rev 18:133-46. 2005
    ..Apart from the urgent need for better tools for the field diagnosis of this neglected disease, improved access to diagnosis and treatment for the population at risk remains the greatest challenge for the coming years...
  2. pmc The burden of human African trypanosomiasis
    Eric M Fèvre
    Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 2:e333. 2008
    Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b...
  3. ncbi Intrathecal cytokine responses in Trypanosoma brucei rhodesiense sleeping sickness patients
    Lorna MacLean
    Department of Zoology, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Trans R Soc Trop Med Hyg 100:270-5. 2006
    Intrathecal cytokine levels and blood-cerebrospinal fluid (CSF) barrier function were studied in 91 Trypanosoma brucei rhodesiense-infected patients...
  4. ncbi Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
    Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by normal human serum (NHS)...
  5. pmc New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289
    Tanja Wenzler
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Antimicrob Agents Chemother 53:4185-92. 2009
    ..In conclusion, DB868 with oral and DB829 with parenteral application are potential candidates for further development of a second-stage African sleeping sickness drug...
  6. ncbi Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys
    M Ngotho
    Institute of Primate Research, Karen, Nairobi, Kenya
    Trop Med Int Health 14:736-47. 2009
    ..To determine the usefulness of IL-10 and immunoglobulin M (IgM) as biomarkers for staging HAT in vervet monkeys, a useful pathogenesis model for humans...
  7. pmc Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania
    Harriet K Auty
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    PLoS Negl Trop Dis 6:e1501. 2012
    Measuring the prevalence of transmissible Trypanosoma brucei rhodesiense in tsetse populations is essential for understanding transmission dynamics, assessing human disease risk and monitoring spatio-temporal trends and the impact of ..
  8. pmc Focus-specific clinical profiles in human African Trypanosomiasis caused by Trypanosoma brucei rhodesiense
    Lorna M MacLean
    Department of Biology, Hull York Medical School, Centre for Immunology and Infection, University of York, York, United Kingdom
    PLoS Negl Trop Dis 4:e906. 2010
    Diverse clinical features have been reported in human African trypanosomiasis (HAT) foci caused by Trypanosoma brucei rhodesiense (T.b...
  9. ncbi A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence
    Jeremy M Sternberg
    Institute of Biological and Environmental Sciences, University of Aberdeen, Zoology Building, Aberdeen AB242TZ, UK
    Parasitology 137:2007-15. 2010
    ..has been known that there are considerable differences in the severity and rate of progression of both Trypanosoma brucei rhodesiense and T. b. gambiense infection between individuals...
  10. pmc Eliminating human African trypanosomiasis: where do we stand and what comes next?
    Pere P Simarro
    World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland
    PLoS Med 5:e55. 2008
  11. ncbi Review Article: cerebrospinal fluid in human African trypanosomiasis: a key to diagnosis, therapeutic decision and post-treatment follow-up
    V Lejon
    Department of Parasitology, Institute of Tropical Medicine, Antwerpen, Belgium
    Trop Med Int Health 10:395-403. 2005
    ..This paper reviews clinical presentation, diagnosis and treatment of the disease, with emphasis on CSF characteristics and interpretation of the CSF results for therapeutic decision and post-treatment follow-up...
  12. pmc Infections with immunogenic trypanosomes reduce tsetse reproductive fitness: potential impact of different parasite strains on vector population structure
    Changyun Hu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Negl Trop Dis 2:e192. 2008
    The parasite Trypanosoma brucei rhodesiense and its insect vector Glossina morsitans morsitans were used to evaluate the effect of parasite clearance (resistance) as well as the cost of midgut infections on tsetse host fitness...
  13. pmc Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration
    R E Mdachi
    Kenya Agricultural Research Institute Trypanosomiasis Research Centre, Kikuyu, Kenya
    Antimicrob Agents Chemother 53:953-7. 2009
    ..Five groups of three animals each were infected intravenously with 10(4) Trypanosoma brucei rhodesiense KETRI 2537 cells. On the seventh day postinfection (p.i...
  14. ncbi Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro
    Abraham Abebe Wube
    Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Karl Franzens University Graz, Universitaetsplatz 4 1, A 8010 Graz, Austria
    Phytother Res 24:1468-72. 2010
    ..and chloroquine-resistant (K1) strains of Plasmodium falciparum and antitrypanosomal activity against Trypanosoma brucei rhodesiense. The dichloromethane extract displayed strong antiplasmodial and antitrypanosomal activities with IC(..
  15. ncbi Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense
    Maina Ngotho
    Institute of Primate Research, Nairobi, Kenya
    Acta Trop 119:14-8. 2011
    ..this study was to characterise the sequential haematological changes in vervet monkeys infected with Trypanosoma brucei rhodesiense and subsequently treated with sub-curative diminazene aceturate (DA) and curative melarsoprol (MelB) ..
  16. ncbi Trypanosomiasis and the brain
    Jean Rodgers
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow
    Parasitology 137:1995-2006. 2010
    ....
  17. pmc A search for Trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning
    Theresa Manful
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 5:e9630. 2010
    ..The only available diagnostic method for East African trypanosomiasis is light microscopy of blood samples. A simple immunodiagnostic would greatly aid trypanosomiasis control...
  18. ncbi Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products (Review)
    Stefanie Gehrig
    Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Int J Mol Med 22:411-9. 2008
    ..This study provides an overview of the recently discovered small molecules with trypanocidal activity against T. b. gambiense and T. b. rhodesiense. In addition, former promising compounds are touched upon...
  19. ncbi Synthesis and antiprotozoal activity of aza-analogues of furamidine
    Mohamed A Ismail
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303 3083, USA
    J Med Chem 46:4761-9. 2003
    ..of less than 10 nM. Against P. f. 8a, 8b, and 14b exhibited IC(50) values less than 10 nM. In an in vivo mouse model for T. b. r. four compounds 6a, 6c, 6d, and 8a were curative. Compound 6a produced cures at an oral dosage of 5 mg/kg...
  20. ncbi Antitrypanosomal and antiplasmodial activity of medicinal plants from Côte d'Ivoire
    K Kamanzi Atindehou
    Laboratoire de Botanique, UFR Biosciences, Universite de Cocody, Abidjan, Ivory Coast
    J Ethnopharmacol 90:221-7. 2004
    ..ethanol extracts derived from 88 medicinal plants from Côte d'Ivoire was determined in vitro using Trypanosoma brucei rhodesiense. Of those extracts 8 showed good activity (IC50 values < or =8 microg/ml), 37 revealed a weak ..
  21. pmc Bromopyrrole alkaloids as lead compounds against protozoan parasites
    Fernando Scala
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano, 49, I 80131, Napoli, Italy
    Mar Drugs 8:2162-74. 2010
    ..Tests against the mammalian L6 cells revealed important clues on therapeutic index of the metabolites. This is the first detailed study on the antiprotozoal potential of marine bromopyrrole alkaloids...
  22. ncbi The continuing problem of human African trypanosomiasis (sleeping sickness)
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, Faculty of Medicine, University of Glasgow Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK
    Ann Neurol 64:116-26. 2008
    ..of the genus Trypanosoma and comes in two types: East African human African trypanosomiasis caused by Trypanosoma brucei rhodesiense and the West African form caused by Trypanosoma brucei gambiense...
  23. pmc Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response
    Lorna MacLean
    Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom
    PLoS Negl Trop Dis 6:e1857. 2012
    ....
  24. ncbi Drug transport and drug resistance in African trypanosomes
    Pascal Maser
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    Drug Resist Updat 6:281-90. 2003
    ..brucei causes melarsoprol resistance. It will be important to determine the role of TbAT1 and TbMRPA in sleeping sickness treatment failures...
  25. ncbi Nitric oxide and cytokine synthesis in human African trypanosomiasis
    L Maclean
    Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom
    J Infect Dis 184:1086-90. 2001
    ..The results indicate that human African trypanosomiasis leads to the development of a strong anti-inflammatory cytokine response...
  26. ncbi Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense
    M Salomé Gachet
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl Franzens University Graz, Universitatsplatz 4, 8010 Graz, Austria
    J Nat Prod 74:559-66. 2011
    ..was found to show significant in vitro activity against the Plasmodium falciparum K1 strain and Trypanosoma brucei rhodesiense. Subsequently, activity-guided isolation of the n-hexane and dichloromethane extracts from the bark of ..
  27. pmc Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
    M P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Br J Pharmacol 152:1155-71. 2007
    ..Finally we report on new initiatives that might allow progress to be made in developing new and satisfactory drugs for this terrible disease...
  28. pmc Loop-mediated isothermal amplification (LAMP) method for rapid detection of Trypanosoma brucei rhodesiense
    Zablon Kithinji Njiru
    School of Nursing, Murdoch University, Mandurah, Western Australia, Australia
    PLoS Negl Trop Dis 2:e147. 2008
    ..In the present study, a LAMP test was designed from the serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense, the cause of the acute form of African sleeping sickness, and used to detect parasite DNA from ..
  29. pmc Clinical presentation of T.b. rhodesiense sleeping sickness in second stage patients from Tanzania and Uganda
    Irene Kuepfer
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e968. 2011
    A wide spectrum of disease severity has been described for Human African Trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense (T.b...
  30. pmc Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles
    Stanislav A Bakunov
    Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Med Chem 53:254-72. 2010
    ..nature of aromatic substituents influenced in vitro antiprotozoal activities of compounds 1-60 against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and their cytotoxicity for mammalian cells...
  31. ncbi Activity of bisphosphonates against Trypanosoma brucei rhodesiense
    Michael B Martin
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA
    J Med Chem 45:2904-14. 2002
    ..molecular field analysis (CoMFA) investigation of the growth inhibition of the bloodstream form of Trypanosoma brucei rhodesiense trypomastigotes by bisphosphonates...
  32. ncbi Public-private partnership works to stamp out sleeping sickness in Uganda
    John D Kabasa
    Trends Parasitol 23:191-2. 2007
  33. pmc Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site
    Jill A Inverso
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    DNA Cell Biol 29:215-27. 2010
    ..The VSG gene sequences expressed by clones LouTat 1 and LouTat 1A of Trypanosoma brucei rhodesiense were identical, and gene expression in both clones occurred precisely by the same gene conversion ..
  34. pmc Dot enzyme-linked immunosorbent assay for more reliable staging of patients with Human African trypanosomiasis
    Bertrand Courtioux
    IENT EA 3174 Neuroparasitologie et Neuroépidémiologie Tropicale, Faculty of Medicine, Limoges, France
    J Clin Microbiol 43:4789-95. 2005
    ..2% sensitivity and 100.0% specificity. Dot-ELISA could be a useful test to diagnose CNS involvement in HAT in the less-equipped laboratories or in the field situation and to improve patient treatment...
  35. pmc Severity of human african trypanosomiasis in East Africa is associated with geographic location, parasite genotype, and host inflammatory cytokine response profile
    Lorna MacLean
    School of Biological Sciences, University of Aberdeen, Zoology Building, Aberdeen AB24 2TZ, Scotland, United Kingdom
    Infect Immun 72:7040-4. 2004
    ..1%), despite infections of several months' duration. All infections were confirmed to be Trypanosoma brucei rhodesiense by testing for the presence of the serum resistance-associated (SRA) gene, but trypanosomes isolated ..
  36. ncbi Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation
    Christophe Dardonville
    Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
    J Med Chem 47:2296-307. 2004
    The in vitro screening for trypanocidal activity against Trypanosoma brucei rhodesiense of an in-house library of 62 compounds [i.e...
  37. ncbi Human African trypanosomiasis and human immunodeficiency virus co-infection in Western Kenya
    G O Matete
    KARI Trypanosomiasis Research Centre, P O Box 362, Kikuyu, Kenya
    East Afr Med J 82:20-3. 2005
    To determine possible interaction between infections of Trypanosoma brucei rhodesiense sleeping sickness and HIV/AIDS in Western Kenya.
  38. ncbi O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection
    John H Ansede
    Division of Drug Delivery and Disposition, School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7360, USA
    J Med Chem 47:4335-8. 2004
    ..analogues of the prodrug 2,5-bis[4-methoxyamidinophenyl]furan were synthesized and evaluated against Trypanosoma brucei rhodesiense in the STIB900 mouse model by oral administration...
  39. ncbi The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense
    Magdalena Radwanska
    Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    Am J Trop Med Hyg 67:684-90. 2002
    In the search for new diagnostic methods that would distinguish Trypanosoma brucei rhodesiense from T. b. brucei and T. b. gambiense, we have developed two polymerase chain reaction (PCR) primer sets...
  40. ncbi Sleeping sickness and the brain
    B Enanga
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Scotland, United Kingdom
    Cell Mol Life Sci 59:845-58. 2002
    ....
  41. ncbi A multiplex PCR that discriminates between Trypanosoma brucei brucei and zoonotic T. b. rhodesiense
    Kim Picozzi
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, Royal Dick School of Veterinary Science, The University of Edinburgh, Edinburgh EH25 9RG, UK
    Exp Parasitol 118:41-6. 2008
    ..b. rhodesiense), inclusion of GPI-PLC as an internal control indicates whether sufficient genomic material is present for detection of a single copy T. brucei gene in the PCR reaction...
  42. ncbi Evidence for multiple origins of human infectivity in Trypanosoma brucei revealed by minisatellite variant repeat mapping
    A MacLeod
    Wellcome Centre of Molecular Parasitology, Anderson College, University of Glasgow, Scotland
    J Mol Evol 52:290-301. 2001
    ....
  43. pmc Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda
    Thomas Zoller
    Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117Berlin, Germany
    BMC Infect Dis 8:88. 2008
    ..e. within affected villages. In the present work, we use a case-control methodology to analyse both behavioural and spatial risk factors for HAT in an endemic area...
  44. ncbi Lessons learned from the emergence of a new Trypanosoma brucei rhodesiense sleeping sickness focus in Uganda
    O C Hutchinson
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Lancet Infect Dis 3:42-5. 2003
    During the latter months of 1998, cases of sleeping sickness caused by Trypanosoma brucei rhodesiense presented in Soroti district, eastern Uganda, a region which had not previously experienced cases of the disease...
  45. pmc C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009
    ..In addition, they provide a possible explanation for the ability of Papio serum to kill T. b. rhodesiense, and offer a perspective to generate transgenic cattle resistant to both T. b. brucei and T. b. rhodesiense...
  46. pmc Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis
    John K Thuita
    Trypanosomiasis Research Centre, KARI TRC, Kikuyu, Kenya
    PLoS Negl Trop Dis 2:e238. 2008
    We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys...
  47. ncbi Treatment and control of human African trypanosomiasis
    J Jannin
    World Health Organization, 1211 Geneva, Switzerland
    Curr Opin Infect Dis 17:565-71. 2004
    ..This paper reviews the development of new diagnostic tools and drugs and the opportunity offered by new technologies for their further improvement...
  48. ncbi Quantifying the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness cases
    M Odiit
    UACP, Kampala, Uganda
    Trop Med Int Health 10:840-9. 2005
    To formally quantify the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness (SS) during an epidemic in Uganda, a decision tree (under-detection) model was developed; concurrently, to quantify the subset of ..
  49. ncbi A burgeoning epidemic of sleeping sickness in Uganda
    E M Fèvre
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian, UK
    Lancet 366:745-7. 2005
    The epidemic of Trypanosoma brucei rhodesiense sleeping sickness in eastern Uganda, which began in 1998 as a result of movements of the livestock reservoir of the parasite, has continued to spread...
  50. ncbi Traversal of human and animal trypanosomes across the blood-brain barrier
    Dennis J Grab
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurovirol 14:344-51. 2008
    ..A clear understanding of how trypanosomes enter the CNS is critical for both understanding the neuropathogenesis of HAT and in developing more effective drug therapies for late-stage disease...
  51. ncbi Expression of alternative oxidase inhibits programmed cell death-like phenomenon in bloodstream form of Trypanosoma brucei rhodesiense
    Akiko Tsuda
    Laboratory of Infectious Disease, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Parasitol Int 54:243-51. 2005
    b>Trypanosoma brucei rhodesiense is one of the causative agents of African Trypanosomiasis. Programmed cell death (PCD) is fundamental in the development, homeostasis and immune mechanisms of multicellular organisms...
  52. ncbi Human African trypanosomiasis: clinical presentation and immune response
    J M Sternberg
    Zoology Building, School of Biological Sciences, University of Aberdeen, UK
    Parasite Immunol 26:469-76. 2004
    ..The impact of dysregulated inflammatory responses in both systemic and CNS pathology will be examined and the potential for host genotype variation in disease severity and control will be discussed...
  53. pmc TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
    J Naessens
    International Livestock Research Institute, Nairobi, Kenya
    Clin Exp Immunol 139:405-10. 2005
    ..In contrast, during an infection with the human pathogen Trypanosoma brucei rhodesiense, the number of red blood cells in TNF-alpha-deficient mice remained significantly higher than in the ..
  54. ncbi Anaemia in human African trypanosomiasis caused by Trypanosoma brucei rhodesiense
    J E Chisi
    College of Medicine, University of Malawi, Private Bag 360, Chichiri, Blantyre 3, Malawi
    East Afr Med J 81:505-8. 2004
    ..To find out if indeed anaemia is a major sign in human trypanosomiasis caused by Trypanosoma brucei rhodensiense...
  55. pmc Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum
    Laixing Hu
    Department of Chemistry, Georgia State University, Atlanta, GA 30303 3083, USA
    Bioorg Med Chem 17:6651-8. 2009
    ..diamidines has been synthesized and evaluated for in vitro antiprotozoal activity against both Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f...
  56. pmc Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda
    Eric M Fèvre
    Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, West Mains Road, Edinburgh, EH9 3JT, UK
    BMC Public Health 8:96. 2008
    Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis), caused by infection with Trypanosoma brucei rhodesiense, is an under-reported and neglected tropical disease...
  57. pmc Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth
    Yuliya V Mishina
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA
    Antimicrob Agents Chemother 51:1852-4. 2007
    Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T...
  58. pmc Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
    Olga V Nikolskaia
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Invest 116:2739-47. 2006
    ..Collectively, these in vitro studies implicate brucipain as a critical driver of T. b. gambiense transendothelial migration of the human BBB...
  59. ncbi IL-10 is up regulated in early and transitional stages in vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense
    Maina Ngotho
    KARI Trypanosomiasis Research Centre, Kikuyu, Kenya
    Parasitol Int 55:243-8. 2006
    ..The IL-10 peak observed on day 42 of infection might indicate onset of parasite neuroinvasion coinciding with a peak in white blood cell counts in the blood and CSF...
  60. ncbi Glossina fuscipes fuscipes in the trypanosomiasis endemic areas of south eastern Uganda: apparent density, trypanosome infection rates and host feeding preferences
    C Waiswa
    Makerere University, Faculty of Veterinary Medicine, P O Box 7062, Kampala, Uganda
    Acta Trop 99:23-9. 2006
    ..The implication of this, in relation to the cycle of transmission for human infective trypanosomes between domestic animals and man, is discussed...
  61. ncbi Human African trypanosomiasis: connecting parasite and host genetics
    Andre Garcia
    Institut de Recherche pour le Developpement, Unité de Recherche 010, Faculte de Pharmacie, 4 avenue de l Observatoire, 75270 Paris, France
    Trends Parasitol 22:405-9. 2006
    ..However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence...
  62. ncbi The trypanolytic factor of human serum
    Etienne Pays
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine IBMM, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Nat Rev Microbiol 4:477-86. 2006
    ..Resistance to this activity has arisen in two subspecies of Trypanosoma brucei - Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense - allowing these parasites to infect humans, and this results in ..
  63. ncbi The rise and fall of sleeping sickness
    Michael P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Lancet 367:1377-8. 2006
  64. ncbi Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance
    Sonja C Bernhard
    Swiss Tropical Institute, Socinstr 57, Basel, Switzerland
    Int J Parasitol 37:1443-8. 2007
    Resistance to melarsoprol and pentamidine was induced in bloodstream-form Trypanosoma brucei rhodesiense STIB 900 in vitro, and drug sensitivity was determined for melarsoprol, pentamidine and furamidine...
  65. ncbi Central point sampling from cattle in livestock markets in areas of human sleeping sickness
    E M Fèvre
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Acta Trop 97:229-32. 2006
    ..We also find that animals infected with trypanosomiasis are more likely to be brought for sale in livestock markets in endemic areas; we discuss these results in relation to the prevention of the spread of sleeping sickness...
  66. pmc Sleeping sickness in Uganda: a thin line between two fatal diseases
    Kim Picozzi
    Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH25 9RG
    BMJ 331:1238-41. 2005
    ..To determine, through the use of molecular diagnostic tools, whether the two species of parasite that cause human African trypanosomiasis have become sympatric...
  67. pmc Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response
    Lorna MacLean
    School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, Scotland
    J Infect Dis 196:1620-8. 2007
    ..The Tororo and Soroti foci of Trypanosoma brucei rhodesiense infection were genetically distinct as characterized by 6 microsatellite and 1 minisatellite ..
  68. ncbi The SRA gene: the key to understanding the nature of Trypanosoma brucei rhodesiense
    W C Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 I UG, UK
    Parasitology 131:143-50. 2005
  69. ncbi Using remote sensing and geographic information systems to identify villages at high risk for rhodesiense sleeping sickness in Uganda
    Martin Odiit
    Sleeping Sickness Programme, National Agricultural Research Organization, LIRI Hospital, P O Box 96, Tororo, Uganda
    Trans R Soc Trop Med Hyg 100:354-62. 2006
    ..These findings demonstrate the potential of remote sensing and GIS to characterize village-level risk of sleeping sickness in endemic regions...
  70. ncbi Detection of Trypanosoma brucei rhodesiense in animals from sleeping sickness foci in East Africa using the serum resistance associated (SRA) gene
    Z K Njiru
    Kenya Trypanosomiasis Research Institute, P O Box 362, Kikuyu, Kenya
    Acta Trop 90:249-54. 2004
    The human serum resistance associated (SRA) gene has been found exclusively in Trypanosoma brucei rhodesiense, allowing the unequivocal detection of this pathogen in reservoir hosts and the tsetse vector without recourse to laborious ..
  71. ncbi Sleeping sickness: a tale of two diseases
    S C Welburn
    Sir Alexander Robertson Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin, EH25 9RG, Midlothian, UK
    Trends Parasitol 17:19-24. 2001
    ..In this review, Susan Welburn, Eric Fèvre, Paul Coleman, Martin Odiit and Ian Maudlin discuss the biology and distribution of these two diseases in relation to the evolution of hominids in Africa...
  72. ncbi A multi-centre evaluation of the card indirect agglutination test for trypanosomiasis (TrypTect CIATT)
    T Asonganyi
    Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon
    Ann Trop Med Parasitol 92:837-44. 1998
    ..0%) had no detectable trypanosome antigens in their peripheral blood. The test could therefore be used for evaluating chemotherapeutic cure, as well as for diagnosis...
  73. ncbi Will the real Trypanosoma brucei rhodesiense please step forward?
    Wendy Gibson
    School of Biological Sciences, University of Bristol, BS8 1UG, Bristol, UK
    Trends Parasitol 18:486-90. 2002
    The sleeping sickness trypanosomes Trypanosoma brucei rhodesiense and T. brucei gambiense are morphologically indistinguishable from each other and from T. brucei brucei, which does not infect humans...
  74. ncbi The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda
    E M Fèvre
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, EH25 9RG, Scotland, UK
    Lancet 358:625-8. 2001
    Sleeping sickness, caused by two trypanosome subspecies, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, is a parasitic disease transmitted by the tsetse fly in sub-Saharan Africa...
  75. pmc Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)
    Naomi Maina
    Primate Division, Kenya Trypanosomiasis Research Institute, Kikuyu, Kenya Department of Zoology, University of Aberdeen, Aberdeen AB29 2TZ, Scotland, United Kingdom
    Infect Immun 72:3063-5. 2004
    ..At no time were these cytokines detectable in the CSF...
  76. ncbi Eflornithine for the treatment of human African trypanosomiasis
    Christian Burri
    Swiss Tropical Institute, Swiss Center for International Health, Socinstrasse 57, P O Box, 4002 Basel, Switzerland
    Parasitol Res 90:S49-52. 2003
    ..Its efficacy against Trypanosoma brucei rhodesiense is limited due to the innate lack of susceptibility of this parasite based on a higher ornithine ..
  77. ncbi Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
    C R Caffrey
    Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, VAMC, 4150 Clement Street-113B, San Francisco, CA 94121, USA
    Mol Biochem Parasitol 118:61-73. 2001
    ..and further characterize the enzyme, we expressed and purified rhodesain, the target protease of Trypanosoma brucei rhodesiense (MVAT4 strain), in reagent quantities from Pichia pastoris...
  78. pmc Minisatellite marker analysis of Trypanosoma brucei: reconciliation of clonal, panmictic, and epidemic population genetic structures
    A MacLeod
    Wellcome Centre of Molecular Parasitology, Anderson College, University of Glasgow, 56, Dumbarton Road, Glasgow, G11 6NU, United Kingdom
    Proc Natl Acad Sci U S A 97:13442-7. 2000
    ....
  79. ncbi Programmed cell death in procyclic form Trypanosoma brucei rhodesiense --identification of differentially expressed genes during con A induced death
    S C Welburn
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Scotland
    Mem Inst Oswaldo Cruz 94:229-34. 1999
    b>Trypanosoma brucei rhodesiense can be induced to undergo apoptosis after stimulation with Con A...
  80. ncbi Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene
    S C Welburn
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, Edinburgh, UK
    Lancet 358:2017-9. 2001
    The expansion of sleeping sickness caused by Trypanosoma brucei rhodesiense beyond its traditional focus in southeast Uganda has been linked with large-scale livestock restocking...
  81. ncbi The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Infect Genet Evol 1:207-14. 2002
    The human serum resistance associated (SRA) gene isolated from a Ugandan strain of Trypanosoma brucei rhodesiense has been shown to be capable by itself of conferring the trait of human infectivity on T.b. brucei by transfection...
  82. ncbi The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense
    Nuria Campillo
    Department of Biochemistry, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Mol Biochem Parasitol 127:79-84. 2003
  83. ncbi Treatment of human African trypanosomiasis--present situation and needs for research and development
    Dominique Legros
    Epicentre, Paris, France
    Lancet Infect Dis 2:437-40. 2002
    ..At the same time, on a long term basis, ambitious research programmes for new compounds must be supported to ensure the sustainable development of new drugs...
  84. ncbi Assessing the patterns of health-seeking behaviour and awareness among sleeping-sickness patients in eastern Uganda
    M Odiit
    Sleeping Sickness Programme, LIRI Hospital, P O Box 96, Tororo, Uganda
    Ann Trop Med Parasitol 98:339-48. 2004
    ....
  85. ncbi Evidence for the occurrence of Trypanosoma brucei rhodesiense sleeping sickness outside the traditional focus in south-eastern Uganda
    J C Enyaru
    Livestock Health Research Institute, Tororo, Uganda
    Ann Trop Med Parasitol 93:817-22. 1999
    The occurrence of Trypanosoma brucei rhodesiense west of the River Nile, in Masindi district in the mid-western part of Uganda, is confirmed. Masindi borders the traditional belt of T. b...
  86. ncbi Are fitness costs associated with resistance to human serum in Trypanosoma brucei rhodesiense?
    Paul G Coleman
    Disease Control and Vector Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
    Trends Parasitol 20:311-5. 2004
  87. ncbi Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera
    Philippe Poelvoorde
    Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Biochem Parasitol 134:155-7. 2004
  88. ncbi Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy
    A M Checkley
    Hospital for Tropical Diseases, London, UK University College Hospital, London, UK
    Trans R Soc Trop Med Hyg 101:523-6. 2007
    ..The clinical presentation was subacute, but the infection was shown to be due to Trypanosoma brucei rhodesiense. The infection relapsed twice following treatment and the patient developed a melarsoprol-associated ..
  89. ncbi Chemotherapy of human African trypanosomiasis
    Richard J S Burchmore
    Iinstitute of Biochemical and Life Sciences, Division of Infection and Immunity, University of Glasgow, UK
    Curr Pharm Des 8:256-67. 2002
    ..Coma precedes death during this late phase. Two forms of the disease are recognised, one caused by Trypanosoma brucei rhodesiense, endemic in Eastern and Southern Africa, in which parasites rapidly invade the CNS causing death ..
  90. ncbi Chemotherapeutic strategies against Trypanosoma brucei: drug targets vs. drug targeting
    A Luscher
    University of Bern, Institute of Cell Biology, Bern, Switzerland
    Curr Pharm Des 13:555-67. 2007
    b>Trypanosoma brucei rhodesiense and T. b. gambiense are the causative agents of sleeping sickness, a fatal disease that affects 36 countries in sub-Saharan Africa. Nevertheless, only a handful of clinically useful drugs are available...
  91. ncbi Evaluation of azasterols as anti-parasitics
    Ludovic Gros
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
    J Med Chem 49:6094-103. 2006
    ..the design and synthesis of some novel azasterols is described, followed by their evaluation against Trypanosoma brucei rhodesiense, T...
  92. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa
    Anne C Moore
    N Engl J Med 346:2069-76. 2002
  93. ncbi African trypanosomiasis
    I Maudlin
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Roslin EH25 9RG, UK
    Ann Trop Med Parasitol 100:679-701. 2006
    ..After more than 100 years of effort, trypanosomiasis control remains a controversial topic, subject to the tides of fashion and politics...
  94. ncbi Combination therapy for sleeping sickness: a wake-up call
    Jacques Pepin
    J Infect Dis 195:311-3. 2007
  95. ncbi [Three patients with African sleeping sickness following a visit to Tanzania]
    M Mendonça Melo
    Havenziekenhuis and Instituut voor Tropische ziekten, afd Interne Geneeskunde, Haringvliet 2, 3011 TD Rotterdam
    Ned Tijdschr Geneeskd 146:2552-6. 2002
    ..She died following repatriation. An epidemic of trypanosomiasis is currently raging through Central Africa. In several western countries, trypanosomiasis has been diagnosed recently in tourists who visited Tanzania...
  96. ncbi Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles
    Donald A Patrick
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Med Chem 50:2468-85. 2007
    ..The 43 isoxazole derivatives were assayed against Trypanosoma brucei rhodesiense (T. brucei rhodesiense) STIB900, Plasmodium falciparum (P...
  97. ncbi Synthesis of bicyclic amines and their activities against Trypanosoma brucei rhodesiense and Plasmodium falciparum K1
    Robert Weis
    Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl Franzens University, Universitatsplatz 1, A 8010, Graz, Austria
    Arch Pharm Res 31:688-97. 2008
    ..2.2]nonanes. Some of the 4-aminobicyclo[2.2.2]oct-2-ylamines exhibit moderate in vivo activity in mice against Trypanosoma brucei brucei...
  98. ncbi Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp
    Anthony D Wright
    Institute for Pharmaceutical Biology, Technical University of Braunschweig, Mendelssohnstrasse 1, 38106 Braunschweig, Germany
    J Med Chem 45:3067-72. 2002
    ..These isolates may well serve as lead structures for the development of new antimalarial drugs...
  99. ncbi Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis
    Gerhard Bringmann
    Institut für Organische Chemie der Universität, Am Hubland, D 97074 Wurzburg, Germany
    J Nat Prod 65:1096-101. 2002
    ..Structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were evaluated...
  100. ncbi New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity
    Fernando Rodriguez
    Centre for Synthesis and Chemical Biology, School of Chemistry, Trinity College Dublin, Dublin 2, Ireland
    J Med Chem 51:909-23. 2008
    A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1...
  101. ncbi Increased trypanolytic activity in sera of sleeping sickness patients after chemotherapy
    A Fischer
    Abteilung Parasitologie, , Heidelberg, Germany
    Trop Med Int Health 6:1070-4. 2001
    ..These results suggest that trypanolytic activity of sera increases after African sleeping sickness and is directed against trypanosomes expressing metacyclic VSG...

Research Grants18

  1. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2013
    ..b. brucei by destabilization of the lysosomal membrane. The human sleeping sickness parasite Trypanosoma brucei rhodesiense has evolved a defense against TLF. T. b...
  2. Evidence based control strategies of Sleeping Sickness vectors
    Serap Aksoy; Fiscal Year: 2012
    ..epidemics in neighboring Uganda and increased movement of people and cattle (known reservoirs for Trypanosoma brucei rhodesiense)...
  3. Origin of Virulence Factors in African Trypanosomes
    ANDREW MCARTHUR; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are protozoan parasites that cause African sleeping sickness in humans while Trypanosoma brucei brucei causes a wasting disease in ..
  4. DEVELOPMENT OF GENETIC TOOLS FOR TRYPANOSOMA BRUCEI
    GEORGE CROSS; Fiscal Year: 2006
    ..remains a significant problem and is a major source of human infection with the virulent Trypanosoma brucei rhodesiense. New drugs are urgently required for all forms of Trypanosomiasis and Leishmaniasis, and understanding ..
  5. IMMUNOBIOLOGY OF AFRICAN TRYPANOSOMIASIS
    John Mansfield; Fiscal Year: 2002
    ..will be studied in which inbred strains of mice differing in immune responsiveness and susceptibility are infected with well characterized Trypanosoma brucei rhodesiense clones that express different antigenic and biological traits.
  6. BIOLOGICAL VARIATION AMONG AFRICAN TRYPANOSOMES
    John Mansfield; Fiscal Year: 2002
    ..transcribed mRNAs and synthesized proteins in genetically related members of the LouTat 1 clone of Trypanosoma brucei rhodesiense and to characterize the genomic organization of these genes...
  7. PROBING THE S' SUBSITES OF CALPAIN
    ISAAC DONKOR; Fiscal Year: 2002
    ..Selected potent and cell permeable inhibitors will be tested in the rat isolated heart ischemia model for cardioprotective effect. ..
  8. Targeting Calpain for Novel Anticancer Agents
    ISAAC DONKOR; Fiscal Year: 2005
    ..Additionally, the compounds are useful biomedical tools for investigating the intracellular roles of Calpain due to their metabolic stability. The compounds are also potential anticancer agents. ..
  9. Water-Soluble and Metabolically Stable Calpain Inhibitors as Cardioprotectants
    ISAAC DONKOR; Fiscal Year: 2008
    ..Furthermore, the proposed studies will provide mechanistic insight into the mode of action of calpain inhibitors as cardioprotectants. ..
  10. Chemoprevention Potential of Calpain Inhibitors
    ISAAC DONKOR; Fiscal Year: 2007
    ..The proposal is significant and innovative because it seeks to investigate calpain as a pharmacological target for the discovery of a new class of chemoprevention agents. [unreadable] [unreadable] [unreadable]..
  11. Adaptive evolution of pathogenesis towards symbiosis
    Serap Aksoy; Fiscal Year: 2009
    ..The role of functions typically associated with pathogenic microorganisms will be pursued in these beneficial microbes. ..
  12. Gene expression in commensal tsetse symbionts
    Brian Weiss; Fiscal Year: 2007
    ..These 'paratransgenic' flies and their offspring will then be monitored for changes in fitness, stability of recombinant protein expression and trypanosome vectorial capacity. ..
  13. Trypanosome gene expression in tsetse
    Serap Aksoy; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  14. INTERACTION OF TSETSE--ITS SYMBIONTS AND TRYPANOSOMES
    Serap Aksoy; Fiscal Year: 2001
    ..The basic knowledge obtained will strengthen our understanding of tsetse biology and will also provide information relevant to other important disease vectors which harbor similar symbionts (e.g., ticks, fleas, reduviid bugs etc.). ..
  15. Modulation of innate immunity by microbial factors
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  16. MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  17. Anaplasma - B. burgorferi/endothelijm interactions
    DENNIS GRAB; Fiscal Year: 2006
    ..burgdorferi. The elucidation of the steps that explain the enhancement may allow for more intensive basic and clinical investigation into mechanisms of virulence for Lyme disease, HGE, and coinfections. ..
  18. Blood-brain barrier traversal by African trypanosomes
    DENNIS GRAB; Fiscal Year: 2005
    ..Armed with this knowledge we will be better able to design therapies that will stop the parasites from entering the brain and prevent many of the agonizing neurological symptoms, which eventually lead to death. ..