anaplasma

Summary

Summary: A genus of gram-negative bacteria whose organisms are obligate parasites of vertebrates. Species are transmitted by arthropod vectors with the host range limited to ruminants. Anaplasma marginale is the most pathogenic species and is the causative agent of severe bovine anaplasmosis.

Top Publications

  1. ncbi Antibodies to Anaplasma marginale major surface proteins 1a and 1b inhibit infectivity for cultured tick cells
    Edmour F Blouin
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078 2007, USA
    Vet Parasitol 111:247-60. 2003
  2. ncbi Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combi
    J S Dumler
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Int J Syst Evol Microbiol 51:2145-65. 2001
  3. pmc Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The Netherlands
    Peter R Wielinga
    Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, Bilthoven 3720 BA, The Netherlands
    Appl Environ Microbiol 72:7594-601. 2006
  4. ncbi Evolution of clinical, haematological and biochemical findings in young dogs naturally infected by vector-borne pathogens
    Donato de Caprariis
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Vet Microbiol 149:206-12. 2011
  5. pmc Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study
    Domenico Otranto
    Department of Veterinary Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano, Bari, Italy
    J Clin Microbiol 48:3316-24. 2010
  6. ncbi Characterization of the functional domain of major surface protein 1a involved in adhesion of the rickettsia Anaplasma marginale to host cells
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, 74078 2007, Stillwater, OK, USA
    Vet Microbiol 91:265-83. 2003
  7. ncbi Prevalence and incidence of tick-borne diseases in smallholder farming systems in the western-Kenya highlands
    O S Okuthe
    National Veterinary Research Centre, Kenya Agricultural Research Institute NVRC KARI, PO Box 32, Kikuyu, Kenya
    Vet Parasitol 141:307-12. 2006
  8. ncbi Anaplasma, Ehrlichia, and "Candidatus Neoehrlichia" bacteria: pathogenicity, biodiversity, and molecular genetic characteristics, a review
    Vera Rar
    Institute of Chemical Biology and Fundamental Medicine, SB RAS, 630090 Novosibirsk, Russian Federation
    Infect Genet Evol 11:1842-61. 2011
  9. pmc Antigenic variation of Anaplasma marginale: major surface protein 2 diversity during cyclic transmission between ticks and cattle
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611, USA
    Infect Immun 69:3057-66. 2001
  10. ncbi Genetic diversity of Anaplasma and Ehrlichia in the Asian part of Russia
    Vera A Rar
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, prosp Lavrent eva 8, 630090 Novosibirsk, Russian Federation
    Ticks Tick Borne Dis 1:57-65. 2010

Detail Information

Publications219 found, 100 shown here

  1. ncbi Antibodies to Anaplasma marginale major surface proteins 1a and 1b inhibit infectivity for cultured tick cells
    Edmour F Blouin
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078 2007, USA
    Vet Parasitol 111:247-60. 2003
    Major surface protein 1 (MSP1) of the cattle pathogen Anaplasma marginale (Rickettsiales: Anaplasmataceae) is a complex of two proteins, MSP1a and MSP1b...
  2. ncbi Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combi
    J S Dumler
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Int J Syst Evol Microbiol 51:2145-65. 2001
    The genera Anaplasma, Ehrlichia, Cowdria, Neorickettsia and Wolbachia encompass a group of obligate intracellular bacteria that reside in vacuoles of eukaryotic cells and were previously placed in taxa based upon morphological, ..
  3. pmc Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The Netherlands
    Peter R Wielinga
    Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, Bilthoven 3720 BA, The Netherlands
    Appl Environ Microbiol 72:7594-601. 2006
    ..Tick densities were calculated, and infection with Borrelia burgdorferi and Anaplasma and Ehrlichia species was investigated by reverse line blot analysis...
  4. ncbi Evolution of clinical, haematological and biochemical findings in young dogs naturally infected by vector-borne pathogens
    Donato de Caprariis
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Vet Microbiol 149:206-12. 2011
    ..In addition, 10 4-month-old beagles were enrolled in each group and used as sentinel dogs. At baseline, Anaplasma platys was the most frequently detected pathogen, followed by Babesia vogeli, Bartonella spp...
  5. pmc Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study
    Domenico Otranto
    Department of Veterinary Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano, Bari, Italy
    J Clin Microbiol 48:3316-24. 2010
    ..Overall, PCR detected the highest number of dogs infected with Anaplasma platys, Babesia vogeli, and Ehrlichia canis, whereas seroconversion was a more sensitive indicator of exposure ..
  6. ncbi Characterization of the functional domain of major surface protein 1a involved in adhesion of the rickettsia Anaplasma marginale to host cells
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, 74078 2007, Stillwater, OK, USA
    Vet Microbiol 91:265-83. 2003
    The major surface protein (MSP) 1a of the genus type species Anaplasma marginale (Rickettsiales: Anaplasmataceae) has been shown to mediate adhesion, infection and transmission of the organism, as well as to contribute to protective ..
  7. ncbi Prevalence and incidence of tick-borne diseases in smallholder farming systems in the western-Kenya highlands
    O S Okuthe
    National Veterinary Research Centre, Kenya Agricultural Research Institute NVRC KARI, PO Box 32, Kikuyu, Kenya
    Vet Parasitol 141:307-12. 2006
    ..05). The difference in disease frequencies in two areas in close proximity shows the importance of monitoring disease events in order to understand and advice farmers in different production and farming systems appropriately...
  8. ncbi Anaplasma, Ehrlichia, and "Candidatus Neoehrlichia" bacteria: pathogenicity, biodiversity, and molecular genetic characteristics, a review
    Vera Rar
    Institute of Chemical Biology and Fundamental Medicine, SB RAS, 630090 Novosibirsk, Russian Federation
    Infect Genet Evol 11:1842-61. 2011
    ..The genera Anaplasma and Ehrlichia as well as the recently specified cluster "Candidatus Neoehrlichia" comprise all bacteria of the ..
  9. pmc Antigenic variation of Anaplasma marginale: major surface protein 2 diversity during cyclic transmission between ticks and cattle
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611, USA
    Infect Immun 69:3057-66. 2001
    The rickettsial pathogen Anaplasma marginale expresses a variable immunodominant outer membrane protein, major surface protein 2 (MSP2), involved in antigenic variation and long-term persistence of the organism in carrier animals...
  10. ncbi Genetic diversity of Anaplasma and Ehrlichia in the Asian part of Russia
    Vera A Rar
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, prosp Lavrent eva 8, 630090 Novosibirsk, Russian Federation
    Ticks Tick Borne Dis 1:57-65. 2010
    ..silvarum ticks--exclusively adults--from the Far East were examined for the presence of Ehrlichia and Anaplasma by nested PCR based on the 16S rRNA gene. Both Anaplasma phagocytophilum and Ehrlichia muris were found in I...
  11. ncbi Ehrlichia platys (Anaplasma platys) in dogs from Maracaibo, Venezuela: an ultrastructural study of experimental and natural infections
    C Arraga-Alvarado
    Unidad de Investigacioned Clínicas Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela
    Vet Pathol 40:149-56. 2003
    Since 1982 Ehrlichia platys, now emended as Anaplasma platys, has been diagnosed in dogs from Maracaibo, Venezuela, using buffy coat smears stained with Dip Quick. Three dogs were inoculated with an A. platys strain...
  12. pmc First case of Anaplasma platys infection in a dog from Croatia
    Viktor Dyachenko
    Institute for Infectious Diseases and Zoonoses, Department for Veterinary Sciences, Faculty for Veterinary Medicine, LMU Munich, Veterinarstrasse 13, 80539 Munich, Germany
    Parasit Vectors 5:49. 2012
    It is known that Anaplasma (A.) platys, the causative agent of infectious canine cyclic thrombocytopenia, is endemic in countries of the Mediterranean basin. However, few reports are available from the Balkans...
  13. pmc Anaplasma phagocytophilum infection in domestic animals in ten provinces/cities of China
    Lijuan Zhang
    Department of Rickettsiology, National Institute of Communicable Disease Control and Prevention, China CDC, Beijing, China
    Am J Trop Med Hyg 87:185-9. 2012
    ..Serum samples from a total of 707 goats, 433 cattle, and 219 dogs were collected for detecting Anaplasma phagocytophilum IgG antibody by immunofluorescence assays and the average seroprevalences were 10...
  14. pmc Multiplex detection of Ehrlichia and Anaplasma species pathogens in peripheral blood by real-time reverse transcriptase-polymerase chain reaction
    Kamesh R Sirigireddy
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, Kansas 66506, USA
    J Mol Diagn 7:308-16. 2005
    ..These include human infections with Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii...
  15. ncbi Detection of Anaplasma phagocytophilum from Wild Boars and Deer in Japan
    Toshiyuki Masuzawa
    Laboratory of Microbiology and Immunology, Faculty of Pharmacy, Chiba Institute of Science, Choshi 288 0025, Japan
    Jpn J Infect Dis 64:333-6. 2011
    This study was conducted to determine the prevalence and geographic distribution of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, in wild deer and boars in Japan...
  16. pmc CD4(+) T lymphocytes from calves immunized with Anaplasma marginale major surface protein 1 (MSP1), a heteromeric complex of MSP1a and MSP1b, preferentially recognize the MSP1a carboxyl terminus that is conserved among strains
    W C Brown
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 69:6853-62. 2001
    Native major surface protein 1 (MSP1) of the ehrlichial pathogen Anaplasma marginale induces protective immunity in calves challenged with homologous and heterologous strains...
  17. ncbi Emergence and genetic variability of Anaplasma species in small ruminants and ticks from Central Europe
    Marketa Derdakova
    Parasitological Institute, Slovak Academy of Sciences, Kosice, Slovak Republic
    Vet Microbiol 153:293-8. 2011
    ..are common tick-borne zoonotic bacterial diseases of livestock and free-living ungulates from the genus Anaplasma that are recently emerging in Central Europe...
  18. ncbi Survey on blood-sucking lice (Phthiraptera: Anoplura) of ruminants and pigs with molecular detection of Anaplasma and Rickettsia spp
    S Hornok
    Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent Istvan University, Istvan u 2, 1078 Budapest, Hungary
    Vet Parasitol 174:355-8. 2010
    ..transmitted by them, anopluran lice (n=1182) were collected in Hungary, and evaluated for the presence of anaplasma, rickettsia and haemotropic mycoplasma DNA...
  19. ncbi Ehrlichiosis and related infections
    Leah A Cohn
    College of Veterinary Medicine, University of Missouri Columbia, 379 East Campus, Clydesdale Hall, Columbia, MO 65211, USA
    Vet Clin North Am Small Anim Pract 33:863-84. 2003
    ..reclassification has resulted in the transfer of several species previously known as Ehrlichia to the genus Anaplasma or Neorickettsia...
  20. ncbi Phylogenetic analysis of the genus Anaplasma in Southwestern China based on 16S rRNA sequence
    Zuoyong Zhou
    Department of Veterinary Medicine, Rongchang Campus of Southwest University, 160 Xueyuan Road, Rongchang County, Chongqing 402460, China
    Res Vet Sci 89:262-5. 2010
    To identify the species within the genus Anaplasma circulating among ruminants in the Southwest of China, we performed the phylogenetic analysis of the 16S rRNA gene of two Anaplasma isolates from cattle and seven from goats...
  21. ncbi Phylogenetic analysis of the erythrocytic Anaplasma species based on 16S rDNA and GroEL (HSP60) sequences of A. marginale, A. centrale, and A. ovis and the specific detection of A. centrale vaccine strain
    Ala E Lew
    Department of Primary Industries, Agency for Food and Fibre Sciences, c o Animal Research Institute, 665 Fairfield Rd, Locked Mail Bag No 4, Yeerongpilly, Moorooka, Queensland 4105, Australia
    Vet Microbiol 92:145-60. 2003
    Phenotypic criteria for the identification of erythrocytic ruminant Anaplasma species has relied on subjective identification methods such as host pathogenicity (virulence for cattle or sheep) and/or the location of Anaplasma inclusion ..
  22. ncbi PCR detection of granulocytic Anaplasma and Babesia in Ixodes ricinus ticks and birds in west-central Poland
    Bogumiła Skotarczak
    Departament of Genetics, Faculty of Biology, Szczecin University, al Piastow 40b, 71 065 Szczecin, Poland
    Ann Agric Environ Med 13:21-3. 2006
    The aim of the study was to establish the role of forest birds as reservoirs of Anaplasma phagocytophilum and Babesia spp. in Wielkopolski National Park. A total of 108 birds from 9 species were collected between May-September 2002...
  23. ncbi Differential adhesion of major surface proteins 1a and 1b of the ehrlichial cattle pathogen Anaplasma marginale to bovine erythrocytes and tick cells
    J de la Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Int J Parasitol 31:145-53. 2001
    b>Anaplasma marginale is a tick-borne ehrlichial pathogen of cattle for which six major surface proteins (MSPs) have been described...
  24. pmc Transovarial transmission of Francisella-like endosymbionts and Anaplasma phagocytophilum variants in Dermacentor albipictus (Acari: Ixodidae)
    Gerald D Baldridge
    Department of Entomology, University of Minnesota, 219 Hodson Hall, 1980 Folwell Ave, St Paul, MN 55108, USA
    J Med Entomol 46:625-32. 2009
    ..albipictus ticks collected from Minnesota white-tailed deer (Odocoileus virginianus) for bacteria of the genera Anaplasma, Ehrlichia, Francisella, and Rickettsia using polymerase chain reaction (PCR) gene amplification and sequence ..
  25. ncbi ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    b>Anaplasma phagocytophilum is an obligate intracellular pathogen that resides within neutrophils and can cause fever, pancytopenia, or death. IFN-gamma plays a critical role in the control of A...
  26. ncbi Detection of Anaplasma platys and Babesia canis vogeli and their impact on platelet numbers in free-roaming dogs associated with remote Aboriginal communities in Australia
    G K Brown
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan NSW 2308, Australia
    Aust Vet J 84:321-5. 2006
    To detect Anaplasma platys and Babesia canis vogeli infection, using polymerase chain reaction (PCR)-based assays, in free-roaming dogs associated with eight Aboriginal communities in remote areas of Australia and to determine the impact ..
  27. ncbi Identification of Borrelia burgdorferi sensu lato, Anaplasma and Ehrlichia species, and spotted fever group Rickettsiae in ticks from Southeastern Europe
    I Christova
    Department of Microbiology, National Center of Infectious and Parasitic Diseases, Boulevard Yanko Sakazov 26, 1504 Sofia, Bulgaria
    Eur J Clin Microbiol Infect Dis 22:535-42. 2003
    ..In this study the presence and identity of Borrelia burgdorferi sensu lato, Ehrlichia, Anaplasma, and Rickettsia species in Bulgarian Ixodes ricinus ticks and in non- Ixodes ticks from Turkey and Albania was ..
  28. pmc Evidence of the importance of host habitat use in predicting the dilution effect of wild boar for deer exposure to Anaplasma spp
    Agustin Estrada-Pena
    Department of Parasitology, Veterinary Faculty, Zaragoza, Spain
    PLoS ONE 3:e2999. 2008
    ..The objective of this study was to explain changes in the exposure rate (ER) of red deer to Anaplasma spp...
  29. pmc Isolation of an Anaplasma sp. organism from white-tailed deer by tick cell culture
    Ulrike G Munderloh
    Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA
    J Clin Microbiol 41:4328-35. 2003
    ..Buffy coat cells were added to ISE6 tick cell cultures and incubated at 34 degrees C, and 8 days later, Anaplasma-like inclusions were demonstrated in Giemsa-stained culture samples...
  30. ncbi Conservation of a gene conversion mechanism in two distantly related paralogues of Anaplasma marginale
    Patrick F M Meeus
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32611 0880, USA
    Mol Microbiol 47:633-43. 2003
    ..b>Anaplasma marginale establishes persistent infection characterized by sequential cycles of rickettsaemia in which new ..
  31. pmc CD4(+) T-lymphocyte and immunoglobulin G2 responses in calves immunized with Anaplasma marginale outer membranes and protected against homologous challenge
    W C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 66:5406-13. 1998
    Protective immunity against the ehrlichial pathogen Anaplasma marginale has been hypothesized to require induction of immunoglobulin G2 (IgG2) antibody against outer membrane protein epitopes and coordinated activation of macrophages for ..
  32. pmc Equine and canine Anaplasma phagocytophilum strains isolated on the island of Sardinia (Italy) are phylogenetically related to pathogenic strains from the United States
    Alberto Alberti
    Istituto di Patologia Speciale e Clinica Medica Veterinaria, Universita degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy
    Appl Environ Microbiol 71:6418-22. 2005
    The presence of Anaplasma phagocytophilum, a tick-transmitted zoonotic pathogen, was investigated in Sardinia using a molecular approach...
  33. pmc Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection
    CHRISTIANE V LOHR
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:6005-12. 2002
    The antigenically variant major surface protein 2 (MSP2) of Anaplasma marginale is expressed from a 3.5-kb operon that contains, in a 5'-to-3' direction, four open reading frames, opag3, opag2, opag1, and msp2...
  34. ncbi Prevalence of four species of Borrelia burgdorferi sensu lato and coinfection with Anaplasma phagocytophila in Ixodes ricinus ticks in central Germany
    A Hildebrandt
    Institute of Medical Microbiology, Friedrich Schiller University, Semmelweisstrasse 4, 07743 Jena, Germany
    Eur J Clin Microbiol Infect Dis 22:364-7. 2003
    ..of Thuringia in central Germany were investigated for infection with Borrelia burgdorferi sensu lato species and Anaplasma phagocytophila. Overall, 11.1% were infected with Borrelia burgdorferi and 2.3% with Anaplasma phagocytophila...
  35. ncbi A sero-epidemiological survey of blood parasites in cattle in the north-eastern Free State, South Africa
    M S Mtshali
    Parasitology Research Programme, Qwa Qwa Campus, University of the Free State, Private Bag X 13, Phuthaditjhaba, 9866 South Africa
    Onderstepoort J Vet Res 71:67-75. 2004
    ..were sero-positive for Babesia bigemina by indirect fluorescent antibody test while 87% were sero-positive for Anaplasma by enzyme-linked immunosorbent assay...
  36. ncbi Molecular survey for Anaplasma bovis and Anaplasma phagocytophilum infection in cattle in a pastureland where sika deer appear in Hokkaido, Japan
    - Jilintai
    Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Jpn J Infect Dis 62:73-5. 2009
    b>Anaplasma bovis and Anaplasma phagocytophilum infection were examined by species-specific nested polymerase chain reaction in cattle in a pastureland where sika deer appear in Hokkaido, Japan...
  37. ncbi The hypervariable region of Anaplasma marginale major surface protein 2 (MSP2) contains multiple immunodominant CD4+ T lymphocyte epitopes that elicit variant-specific proliferative and IFN-gamma responses in MSP2 vaccinates
    Wendy C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 170:3790-8. 2003
    Major surface protein 2 (MSP2) is an immunodominant outer membrane protein of Anaplasma marginale and Anaplasma phagocytophilum pathogens that cause bovine anaplasmosis and human granulocytic ehrlichiosis, respectively...
  38. ncbi Functional genomics and evolution of tick-Anaplasma interactions and vaccine development
    Jose De La Fuente
    Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078, USA
    Vet Parasitol 167:175-86. 2010
    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health...
  39. ncbi Genetic characterization of Anaplasma (Ehrlichia) platys in dogs in Spain
    E Aguirre
    Departamento de Medicina y Cirugia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Vet Med B Infect Dis Vet Public Health 53:197-200. 2006
    This paper reports the first genetic characterization of Anaplasma (Ehrlichia) platys in Spain from a naturally infected dog. The dog presented clinical signs compatible with canine ehrlichiosis...
  40. ncbi Prevalence and genetic diversity of Babesia and Anaplasma species in cattle in Sudan
    Hoyam Awad
    Central Veterinary Research Laboratories, Al Amarat, P O Box 8067, Khartoum, Sudan
    Vet Parasitol 181:146-52. 2011
    ..Sudan were collected from apparently healthy cattle (n=692), DNA was extracted and the prevalence of Babesia and Anaplasma species was analyzed by PCR...
  41. pmc Major histocompatibility complex class II DR-restricted memory CD4(+) T lymphocytes recognize conserved immunodominant epitopes of Anaplasma marginale major surface protein 1a
    Wendy C Brown
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 70:5521-32. 2002
    Native major surface protein 1 (MSP1) of Anaplasma marginale, composed of covalently associated MSP1a and MSP1b proteins, stimulates protective immunity in cattle against homologous and heterologous strain challenge...
  42. pmc Comparison of surface proteins of Anaplasma marginale grown in tick cell culture, tick salivary glands, and cattle
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville USA
    Infect Immun 67:102-7. 1999
    b>Anaplasma marginale, a tick-borne rickettsial pathogen of cattle, infects bovine erythrocytes, resulting in mild to severe hemolytic disease that causes economic losses in domestic livestock worldwide. Recently, the Virginia isolate of A...
  43. ncbi The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs in China
    Z Xia
    Internal Medicine Laboratory, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    J Helminthol 86:185-9. 2012
    A survey of the occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs was undertaken in the People's Republic of China between October 2008 and October 2009...
  44. ncbi Introduction to the alpha-proteobacteria: Wolbachia and Bartonella, Rickettsia, Brucella, Ehrlichia, and Anaplasma
    Dwight D Bowman
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Top Companion Anim Med 26:173-7. 2011
    ..felis, Anaplasma platys, Ehrlichia canis, E. chaffeensis, and E. ewingii...
  45. ncbi Antibody prevalence of eight ruminant infectious diseases in California mule and black-tailed deer (Odocoileus hemionus)
    B B Chomel
    University of California, School of Veterinary Medicine, Department of Epidemiology and Preventive Medicine, Davis 95616
    J Wildl Dis 30:51-9. 1994
    ..Overall antibody prevalence was 56% for Anaplasma marginale, 31% for Borrelia burgdorferi, 16% for bluetongue virus serotype 17, 15% for epizootic hemorrhagic ..
  46. pmc The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy
    A F Barbet
    Department of Infectious Diseases, College of Veterinary Medicine, University of Florida, Gainesville 32611 0633
    Infect Immun 59:971-6. 1991
    A gene for the beta subunit of the immunoprotective surface antigen MSP-1 of Anaplasma marginale was previously cloned and expressed in Escherichia coli. A nucleic acid probe based on this gene detects A...
  47. ncbi The identification of Anaplasma spp. isolated from fallow deer (Dama dama) on a free-range farm in eastern Poland
    L Adaszek
    Department of Epizootiology and Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 30 Głeboka St 20 612 Lublin, Poland
    Pol J Vet Sci 15:393-4. 2012
    The aim of the present study was to investigate the occurrence of Anaplasma spp...
  48. pmc Strain composition of the ehrlichia Anaplasma marginale within persistently infected cattle, a mammalian reservoir for tick transmission
    G H Palmer
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Clin Microbiol 39:631-5. 2001
    ..In the present study, we examined the strain structure of Anaplasma marginale, a genogroup II ehrlichial pathogen, in both an acute outbreak and in persistently infected cattle ..
  49. ncbi A msp1alpha polymerase chain reaction assay for specific detection and differentiation of Anaplasma marginale isolates
    A E Lew
    Queensland Department of Primary Industries, Agency for Food and Fibre Sciences, c o Animal Research Institute, Locked Mail Bag No 4, Qld 4105, Moorooka, Australia
    Vet Microbiol 86:325-35. 2002
    b>Anaplasma marginale is the causative agent of bovine anaplasmosis, a disease which can be protected by vaccination with the less pathogenic Anaplasma species, A. centrale...
  50. pmc Molecular survey and genetic identification of Anaplasma species in goats from central and southern China
    Zhijie Liu
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, People s Republic of China
    Appl Environ Microbiol 78:464-70. 2012
    b>Anaplasma species are obligate intracellular rickettsial pathogens that impact the health of humans and animals. Few studies have been carried out on Anaplasma infections in central and southern China...
  51. ncbi Anaplasma marginale inactivated vaccine: dose titration against a homologous challenge
    S D Rodriguez
    Centro Nacional de Investigaciones Disciplinarias en Parasitologia Veterinaria, INIFAP, Sagar, Mexico
    Comp Immunol Microbiol Infect Dis 23:239-52. 2000
    The present study was performed to dose-titrate an Anaplasma marginale experimental immunogen derived from partially purified initial bodies from three geographically different Mexican strains...
  52. pmc Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian
    Ricardo G Maggi
    Department of Clinical Sciences, Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA
    Parasit Vectors 6:103. 2013
    ..Prior diagnostic testing resulted in findings that were inconclusive or within normal reference ranges and no etiological diagnosis had been obtained to explain the patient's symptoms...
  53. pmc Specific expression of Anaplasma marginale major surface protein 2 salivary gland variants occurs in the midgut and is an early event during tick transmission
    CHRISTIANE V LOHR
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:114-20. 2002
    Infectivity of Anaplasma spp. develops when infected ticks feed on a mammalian host (transmission feed)...
  54. ncbi Failure to demonstrate Babesia, Anaplasma or Ehrlichia in thrombocytopenic dogs from St Kitts
    Patrick J Kelly
    Ross University School of Veterinary Medicine, PO Box 334, Basseterre, St Kitts, West Indies
    J Infect Dev Ctries 3:561-3. 2009
    Thrombocytopenia is common in dogs on St Kitts but there is no data on the possible etiological role played by infections with Anaplasma, Babesia and Ehrlichia, other than E. canis, which are known to occur in the Caribbean.
  55. ncbi Detection of Anaplasma bovis and Anaplasma phagocytophilum DNA from Haemaphysalis megaspinosa in Hokkaido, Japan
    Kaoru Yoshimoto
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Japan
    Vet Parasitol 168:170-2. 2010
    ..collected by flagging in a pasture in Hidaka district (Hokkaido, Japan) was examined for infection with Anaplasma bovis and A. phagocytophilum by species-specific nested PCR. Of the 48 H. megaspinosa nymphs, examined, 1 (2...
  56. ncbi Molecular basis for vaccine development against the ehrlichial pathogen Anaplasma marginale
    G H Palmer
    Program in Vector Borne Diseases, Washington State University, Pullman, WA 99164 7040, USA
    Parasitol Today 15:281-6. 1999
    b>Anaplasma marginale is a tick-transmitted ehrlichial pathogen causing severe morbidity and mortality in livestock on six continents...
  57. ncbi Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila
    Robert F Massung
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    DNA Cell Biol 21:587-96. 2002
    The rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila have been analyzed. The 16S rRNA genes were previously characterized for both of these agents...
  58. ncbi Detection of Anaplasma bovis and Anaplasma phagocytophilum from cattle on Yonaguni Island, Okinawa, Japan
    Mamoru Ooshiro
    Okinawa Prefectural Institute of Animal Health, Naha, Okinawa 900 0024, Japan
    Vet Parasitol 154:360-4. 2008
    DNA fragments of Anaplasma bovis and Anaplasma phagocytophilum were detected in cattle on Yonaguni Island, Okinawa, Japan...
  59. pmc Differences in prevalence of Borrelia burgdorferi and Anaplasma spp. infection among host-seeking Dermacentor occidentalis, Ixodes pacificus, and Ornithodoros coriaceus ticks in northwestern California
    Robert S Lane
    Dept of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA
    Ticks Tick Borne Dis 1:159-67. 2010
    ..infected occasionally with the agents of Lyme disease (Borrelia burgdorferi) or human granulocytic anaplasmosis (Anaplasma phagocytophilum) and that it is an inefficient experimental vector of B. burgdorferi...
  60. pmc The Anaplasma marginale msp5 gene encodes a 19-kilodalton protein conserved in all recognized Anaplasma species
    E S Visser
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040
    Infect Immun 60:5139-44. 1992
    Immunization with Anaplasma marginale outer membranes induced immunity against clinical disease which correlated with antibody titer to outer membrane proteins, including a 19-kDa protein (N. Tebele, T. C. McGuire, and G. H...
  61. ncbi In vitro cultivation of a south African isolate of an Anaplasma sp. in tick cell cultures
    E Zweygarth
    Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort 0110, South Africa
    Onderstepoort J Vet Res 73:251-5. 2006
    This paper describes the first successful in vitro cultivation of a South African isolate of an Anaplasma sp., initially thought to be Anaplasma marginale, in the continuous tick cell line IDE8...
  62. ncbi Molecular detection of Ehrlichia canis, Anaplasma bovis, Anaplasma platys, Candidatus Midichloria mitochondrii and Babesia canis vogeli in ticks from Israel
    S Harrus
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Clin Microbiol Infect 17:459-63. 2011
    ..ticks were collected. Screening by molecular techniques revealed the presence of Ehrlichia canis, Anaplasma platys, Anaplasma bovis and Babesia canis vogeli DNA in R. turanicus ticks. E. canis, A. bovis, B...
  63. pmc Comparative study of Anaplasma parasites in tick carrying buffaloes and cattle
    Z I Rajput
    J Zhejiang Univ Sci B 6:1057-62. 2005
    A comparative study on the prevalence of Anaplasma parasite was conducted on ticks carrying buffaloes and cattle. Five hundred blood samples of both animals (250 of each) were collected during February, March and April...
  64. pmc Expression of Anaplasma marginale major surface protein 2 variants in persistently infected ticks
    J de la Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma 74078 2007, USA
    Infect Immun 69:5151-6. 2001
    b>Anaplasma marginale, an intraerythrocytic ehrlichial pathogen of cattle, establishes persistent infections in both vertebrate (cattle) and invertebrate (tick) hosts. The ability of A...
  65. ncbi New genetic variants of Anaplasma phagocytophilum and Anaplasma bovis from Korean water deer (Hydropotes inermis argyropus)
    Jun Gu Kang
    Laboratory of Veterinary Internal Medicine, Research Institute and BK21 Program for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Vector Borne Zoonotic Dis 11:929-38. 2011
    Wild deer are one of the important natural reservoir hosts of Anaplasma species, which cause granulocytic anaplasmosis in equines, canines, and humans...
  66. ncbi Associations between coinfection prevalence of Borrelia lusitaniae, Anaplasma sp., and Rickettsia sp. in hard ticks feeding on reptile hosts
    Radovan Václav
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 84506 Bratislava, Slovakia
    Microb Ecol 61:245-53. 2011
    ..unexamined host-vector-pathogen system--green lizards Lacerta viridis, hard ticks Ixodes ricinus, and Borrelia, Anaplasma, and Rickettsia pathogens...
  67. pmc Genetic variability and stability of Anaplasma phagocytophila msp2 (p44)
    Karen Caspersen
    Department of Pathology Division of Medical Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Infect Immun 70:1230-4. 2002
    b>Anaplasma (Ehrlichia) phagocytophila's major immunodominant surface protein antigen, Msp2 (P44, 44-kDa antigen), is encoded by a family of paralogous genes characterized by conserved sequences flanking a hypervariable region...
  68. ncbi Amplification of 16S rRNA genes of Anaplasma species in China for phylogenetic analysis
    Zhijie Liu
    Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 11, Lanzhou, Gansu 730 046, China
    Vet Microbiol 107:145-8. 2005
    ..In this study, a phylogenetic tree was inferred through comparing five 16S rRNA gene sequences of four isolates of Anaplasma ovis and one of Anaplasma marginale in China with all nineteen 16S rRNA gene sequences deposited in GenBank (12 ..
  69. pmc Roles of p38 mitogen-activated protein kinase, NF-kappaB, and protein kinase C in proinflammatory cytokine mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to Anaplasma phagocytophila
    Hyung Yong Kim
    Department of Veterinary Biosciences, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 70:4132-41. 2002
    b>Anaplasma phagocytophila, an obligately intracellular bacterium of granulocytes, causes human granulocytic ehrlichiosis. Within 2 h after addition of A...
  70. ncbi Effects of Anaplasma phagocytophilum infection on the molting success of Ixodes scapularis (Acari: Ixodidae) larvae
    Danielle E Ross
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Med Entomol 41:476-83. 2004
    ..the same or overlapping geographic areas) and allopatric (occurring in separate geographic areas) isolates of Anaplasma phagocytophilum on the survival of Ixodes scapularis Say larvae that were derived from ticks collected in ..
  71. pmc Analysis of the 16S rRNA gene sequence of Anaplasma centrale and its phylogenetic relatedness to other ehrlichiae
    H Inokuma
    Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan
    Clin Diagn Lab Immunol 8:241-4. 2001
    The nucleotide sequence of the Anaplasma centrale 16S rRNA gene was determined and compared with the sequences of ehrlichial bacteria. The sequence of A. centrale was closely related to Anaplasma marginale by both level-of-similarity (98...
  72. ncbi Molecular detection and identification of Ehrlichia and Anaplasma species in ixodid ticks
    Munir Aktas
    Department of Parasitology, College of Veterinary Medicine, Firat University, Elazig, Turkey
    Parasitol Res 104:1243-8. 2009
    ..followed by partial sequencing of the 16S ribosomal RNA gene was performed for the presence of Ehrlichia and/or Anaplasma. A total of 242 ixodid ticks were collected from domestic ruminants and their shelters, as well as humans, and ..
  73. ncbi Detection of members of the genera Rickettsia, Anaplasma, and Ehrlichia in ticks collected in the Asiatic part of Russia
    Stanislav Shpynov
    Unité des Rickettsies CNRS UMR6020, IFR48, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Ann N Y Acad Sci 1078:378-83. 2006
    ..heilongjiangensis, R. helvetica, and Anaplasma phagocytophilum...
  74. pmc Simultaneous detection of Anaplasma marginale and a new Ehrlichia species closely related to Ehrlichia chaffeensis by sequence analyses of 16S ribosomal DNA in Boophilus microplus ticks from Tibet
    Bohai Wen
    Department of Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    J Clin Microbiol 40:3286-90. 2002
    ..One sequence was identical to that of the gene of Anaplasma marginale, an etiological agent of animal anaplasmosis...
  75. ncbi Factors contributing to emergence of Ehrlichia and Anaplasma spp. as human pathogens
    B Doudier
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, Marseille, France
    Vet Parasitol 167:149-54. 2010
    ..In this review, we will present human and animal ehrlichioses and anaplasmoses as emerging diseases and present candidate(s) for the future...
  76. ncbi Detection of Anaplasma phagocytophilum in animals by real-time polymerase chain reaction
    Dagmar Hulinska
    National Institute of Public Health, National Reference Laboratory for Lyme Disease, Division of Microbiology and Epidemiology, Prague, Czech Republic
    APMIS 112:239-47. 2004
    The aim of this study was to detect Anaplasma phagocytophilum in wild and domesticated animals and to identify the phylogenetic relationships of different strains of this bacterium...
  77. ncbi Molecular detection of Anaplasma platys and Ehrlichia canis in dogs from the North of Portugal
    Luis Cardoso
    Department of Veterinary Sciences and CECAV, University of Tras os Montes e Alto Douro, P O Box 1013, 5001 801 Vila Real, Portugal
    Vet J 183:232-3. 2010
    Tick-transmitted rickettsial pathogens belonging to the Ehrlichia and Anaplasma genera can infect dogs and humans...
  78. ncbi Molecular characterization of Thai Ehrlichia canis and Anaplasma platys strains detected in dogs
    Danai Pinyoowong
    Department of Genetics, Faculty of Science, Kasetsart University, Thailand
    Infect Genet Evol 8:433-8. 2008
    ..of this study was to characterize and establish molecular structure and phylogeny of Thai Ehrlichia and Anaplasma strains...
  79. ncbi A new PCR-RFLP method for detection of Anaplasma marginale based on 16S rRNA
    Vahid Noaman
    Veterinary Department of Isfahan Research Center for Agriculture and Natural Resources, Isfahan, Iran
    Vet Res Commun 34:43-50. 2010
    Species of the genus Anaplasma (Rickettsiales: Anaplasmataceae) are obligate intracellular tick borne pathogens. Three species of Anaplasma that infect cattle and sheep (A. marginale, A. centrale and A. ovis) are well recognized...
  80. ncbi Analysis of 16S rRNA gene sequences of Ehrlichia canis, Anaplasma platys, and Wolbachia species from canine blood in Japan
    Ahmet Unver
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1093, USA
    Ann N Y Acad Sci 990:692-8. 2003
    ..sequencing the 16S rRNA genes, each dog was found to be infected either with Ehrlichia canis (Kagoshima 1), Anaplasma platys (Okinawa 1), or Wolbachia sp. (Okinawa 2). Phylogenic analysis was performed on these sequences...
  81. ncbi Simultaneous detection of Anaplasma and Ehrlichia species in ruminants and detection of Ehrlichia ruminantium in Amblyomma variegatum ticks by reverse line blot hybridization
    Cornelis P J Bekker
    Division of Bacteriology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands
    Vet Microbiol 89:223-38. 2002
    The detection of Anaplasma and Ehrlichia species is usually based on species-specific PCR assays, since no assay is yet available which can detect and identify these species simultaneously...
  82. pmc Determination of the nucleotide sequences of heat shock operon groESL and the citrate synthase gene (gltA) of Anaplasma (Ehrlichia) platys for phylogenetic and diagnostic studies
    Hisashi Inokuma
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 753 8515 Yamaguchi, Japan
    Clin Diagn Lab Immunol 9:1132-6. 2002
    ..sequence of the heat shock operon groESL and the 1,236-bp sequence of the citrate synthase gene (gltA) of Anaplasma (Ehrlichia) platys were determined...
  83. ncbi Major surface protein 1a effects tick infection and transmission of Anaplasma marginale
    J de la Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Int J Parasitol 31:1705-14. 2001
    b>Anaplasma marginale, an ehrlichial pathogen of cattle and wild ruminants, is transmitted biologically by ticks. A developmental cycle of A...
  84. ncbi Detection of haemoparasites in cattle by reverse line blot hybridisation with a note on the distribution of ticks in Sicily
    K Georges
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.165, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 99:273-86. 2001
    ..RLB) of 21 oligonucleotides with polymerase chain reaction (PCR) amplified regions of 16S rRNA (Ehrlichia/Anaplasma group) or 18S rRNA (Babesia/Theileria group) genes of haemoparasites detected Theileria annulata, T...
  85. ncbi Phylogenetic relationships of Anaplasma marginale and 'Ehrlichia platys' to other Ehrlichia species determined by GroEL amino acid sequences
    X J Yu
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0609, USA
    Int J Syst Evol Microbiol 51:1143-6. 2001
    The heat-shock protein (GroEL) genes of Anaplasma marginale, Ehrlichia muris and 'Ehrlichia platys' were sequenced and compared with the GroEL of other species of Ehrlichia. The GroEL amino acid sequences of A. marginale and 'E...
  86. ncbi Molecular phylogeny and biogeography of North American isolates of Anaplasma marginale (Rickettsiaceae: Ehrlichieae)
    J de la Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Vet Parasitol 97:65-76. 2001
    b>Anaplasma marginale (A. marginale) is a tick-borne ehrlichial pathogen of cattle that causes the disease anaplasmosis. Six major surface proteins (MSPs) have been identified on A...
  87. ncbi Highly conserved regions of the immunodominant major surface protein 2 of the genogroup II ehrlichial pathogen Anaplasma marginale are rich in naturally derived CD4+ T lymphocyte epitopes that elicit strong recall responses
    W C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 166:1114-24. 2001
    ..including the agent of human granulocytic ehrlichiosis, Ehrlichia phagocytophila, and the bovine pathogen Anaplasma marginale, express a markedly immunodominant outer membrane protein designated major surface protein 2 (MSP2)...
  88. pmc Antigenic variation of Anaplasma marginale by expression of MSP2 mosaics
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611 0880, USA
    Infect Immun 68:6133-8. 2000
    b>Anaplasma marginale is a tick-borne pathogen, one of several closely related ehrlichial organisms that cause disease in animals and humans...
  89. pmc Persistence of Anaplasma ovis infection and conservation of the msp-2 and msp-3 multigene families within the genus Anaplasma
    G H Palmer
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 66:6035-9. 1998
    Goats which have recovered from acute Anaplasma ovis infection remain seropositive, although infected erythrocytes cannot be detected by microscopic examination. Persistence of A...
  90. pmc Anaplasma marginale major surface protein 3 is encoded by a polymorphic, multigene family
    A R Alleman
    Department of Physiological Sciences, University of Florida, Gainesville 32610, USA
    Infect Immun 65:156-63. 1997
    The immunodominant surface protein, MSP3, is structurally and antigenically polymorphic among strains of Anaplasma marginale...
  91. ncbi PCR detection of Anaplasma platys in blood and tissue of dogs during acute phase of experimental infection
    S M Eddlestone
    Louisiana State University School of Veterinary Medicine, Department of Veterinary Clinical Sciences, Baton Rouge, LA 70803, USA
    Exp Parasitol 115:205-10. 2007
    Four dogs were experimentally infected with Anaplasma platys to determine changes in real-time TaqMan PCR detection in blood and tissue, microscopically detectable parasitemia, and platelet concentrations during the first 28 days of ..
  92. pmc Detection of Ehrlichia spp., Anaplasma spp., Rickettsia spp., and other eubacteria in ticks from the Thai-Myanmar border and Vietnam
    Philippe Parola
    Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok
    J Clin Microbiol 41:1600-8. 2003
    ..They were tested by PCR to detect DNA of bacteria of the order RICKETTSIALES: Three Anaplasma spp. were detected in ticks collected in Thailand, including (i) Anaplasma sp...
  93. pmc Molecular characterization of Anaplasma platys strains from dogs in Sicily, Italy
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, 250 McElroy Hall, Oklahoma State University, Stillwater, OK 74078, USA
    BMC Vet Res 2:24. 2006
    The genetic diversity of Anaplasma platys (Rickettsiales: Anaplasmataceae) strains is currently poorly defined. The present study was designed to characterize A...
  94. ncbi Conservation of major surface protein 1 genes of Anaplasma marginale during cyclic transmission between ticks and cattle
    Michael V Bowie
    Department of Pathobiology, University of Florida, PO Box 110880, Gainesville, FL 32611 0880, USA
    Gene 282:95-102. 2002
    Bovine anaplasmosis is a rickettsial disease of world-wide economic importance caused by Anaplasma marginale...
  95. ncbi Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion
    Kelly A Brayton
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Mol Microbiol 43:1151-9. 2002
    The rickettsial pathogen Anaplasma marginale establishes lifelong persistent infection in the mammalian reservoir host, during which time immune escape variants continually arise in part because of variation in the expressed copy of the ..
  96. ncbi Epidemiology of bovine tick-borne diseases in southern Italy
    Giuseppe Cringoli
    Dipartimento di Patologia e Sanita Animale, Universita degli Studi di Napoli Federico II, Italy
    Vet Res 33:421-8. 2002
    ..Serum samples were tested for antibodies of Bahesia bigemina, Babesia bovis and Anaplasma marginale with an ELISA technique. Eight farms (9.8%) out of the 81 examined were positive for B...
  97. ncbi Prevalence of Anaplasma sp. in goats and sheep in Cyprus
    Dimosthenis Chochlakis
    Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine WHO Collaborating Center, Medical School, University of Crete, Heraklion, Greece
    Vector Borne Zoonotic Dis 9:457-63. 2009
    A seroprevalence study of Anaplasma infection was conducted in a stratified random sample of goats and sheep in Cyprus in which the sample locations were recorded using a geographical information system (GIS)...
  98. ncbi Phylogeography of New World isolates of Anaplasma marginale based on major surface protein sequences
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA
    Vet Microbiol 88:275-85. 2002
    Gene and protein sequences of major surface proteins (MSP) 1a and 4 of Anaplasma marginale (Rickettsiales: Anaplasmataceae) were used to infer phylogenetic relationships between New World isolates from Argentina, Brazil, Mexico and the ..
  99. pmc Effects of Anaplasma phagocytophila on NADPH oxidase components in human neutrophils and HL-60 cells
    Jason Mott
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1092, USA
    Infect Immun 70:1359-66. 2002
    The human granulocytic ehrlichiosis agent, Anaplasma phagocytophila, resides and multiplies exclusively in cytoplasmic vacuoles of granulocytes. A...
  100. ncbi Detection and identification of Anaplasma phagocytophilum, Borrelia burgdorferi, and Rickettsia helvetica in Danish Ixodes ricinus ticks
    S Skarphedinsson
    Institute of Clinical Research, University of Southern Denmark, Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark
    APMIS 115:225-30. 2007
    ..The aim of this study was to look for Anaplasma phagocytophilum and related pathogens in Ixodes ricinus ticks and estimate their prevalence, compared to ..
  101. pmc Identification of Anaplasma phagocytophila (formerly Ehrlichia phagocytophila) variants in blood from sheep in Norway
    Snorre Stuen
    Department of Sheep and Goat Research, Norwegian School of Veterinary Science, Sandnes, Norway
    J Clin Microbiol 40:3192-7. 2002
    A total of 41 blood samples were collected from 40 Anaplasma phagocytophila-infected sheep in 11 sheep flocks from four different counties of southern Norway...

Research Grants62

  1. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..Rickettsial group of organisms (Scrub typhus, Spotted fever group, Ehrlichia, Anaplasma etc...
  2. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..we propose to build on key accomplishments from the prior funding period: 1) isolation of non-human-infectious Anaplasma phagocytophilum (Ap) from Camp Ripley, MN, ticks;2) stable transformation of Ap and identification of genes ..
  3. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..provided by applicant): Ixodes scapularis ticks transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among ..
  4. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum and Ehrlichia chaffeensis cause emerging potentially fatal infectious diseases human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME), respectively...
  5. Immunogenicity of the Type IV Secretin System
    WENDY CATHERINE BROWN; Fiscal Year: 2012
    ..We propose to use the Anaplasma marginale model to test the hypothesis that immunization with a linked immunogen composed of naturally ..
  6. Subverted host cell signaling by AnkA in Anaplasma phagocytophilum infection
    Jacob W IJdo; Fiscal Year: 2012
    b>Anaplasma phagocytophilum, is a human pathogen that infects neutrophils and causes Human Granulocytic Ehrlichiosis. In the Unites States it is the second most common tick-associated infection, only surpassed by Lyme disease...
  7. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    ..proteomics, pathogen proteins specifically up-regulated during tick colonization have been identified for both Anaplasma and Ehrlichia...
  8. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2013
    ..The causative agent, Anaplasma phagocytophilum, is an obligate intracellular pathogen that resides in 2 different locations during its life ..
  9. Development of Paratransgenic ticks for Disease Control
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..we will optimize the Himar1 transposase system that we have successfully applied to transformation of tick-borne Anaplasma phagocytophilum, for SFG rickettsiae. This will address the recently found bias of Tn5 for GC rich regions...
  10. Anaplasma regulation of host granulocyte function
    John Stephen Dumler; Fiscal Year: 2013
    ..provided by applicant): Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  11. Human pathogenic bacterium induces actin phosphorylation to selectively regulate
    Hameeda Sultana; Fiscal Year: 2012
    ..Using Ixodes scapularis ticks and Anaplasma phagocytophilum (the agent of human granulocytic anaplasmosis) as an infection model, I provide evidence for the ..
  12. Characterization of an Anaplasma phagocytophilum protein interfering with eukaryo
    Sukanya Narasimhan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum, the causative agent of human Anaplasmosis, is a tick-borne pathogen with an unusual tropism for the front-line immune defense cells (neutrophils)...
  13. Evolution of chronic infection in Anasplasma phagocytophilum
    Anthony F Barbet; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The tick-transmitted rickettsial pathogens Anaplasma phagocytophilum and A. marginale cause potentially fatal, acute or chronic disease of man and animals...
  14. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is a tick-borne obligate intracellular bacterial pathogen and the agent of granulocytic anaplasmosis in humans and animals. A...
  15. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is a tick-borne obligate intracellular bacterial pathogen and the agent of granulocytic anaplasmosis in humans and animals. A...
  16. Antigenic variation in microbial transmission
    GUY HUGHES PALMER; Fiscal Year: 2013
    ..Using Anaplasma marginale as a model in which we can study pathogen infectivity and transmission in a natural mammalian host, we ..
  17. Vector and Host Contributions to the Regulation of E. chaffeensis Gene Expression
    Roman R Ganta; Fiscal Year: 2012
    ..DESCRIPTION (provided by applicant): Illnesses caused by the tick-borne rickettsiales of the genera Ehrlichia and Anaplasma have been a growing health concern in recent years...
  18. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..These equipment and facilities are, however, assumed to be available in the laboratory of Dr. Knowles based on his research activities. ..
  19. Vector and Host Contributions to the Regulation of E. chaffeensis Gene Expression
    Roman R Ganta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Illnesses caused by rickettsiales of the genera Ehrlichia and Anaplasma are a growing human health concern in recent years and are the second leading cause of tick-borne infections in the USA...
  20. Keys to prevent cholesterol robbery and infection by intracellular bacteria
    Yasuko Rikihisa; Fiscal Year: 2013
    ..This disease is caused by infection with the obligatory intracellular bacterium, Anaplasma phagocytophilum. Given the propensity of A...
  21. Anaplasma phagocytophilum induce Ixodes scapularis antifreeze glycoprotein gene e
    Girish Neelakanta; Fiscal Year: 2012
    ..Upper Midwest parts of United States, and transmit various human pathogens that include human anaplasmosis agent Anaplasma phagocytophilum. My preliminary data show that the presence of A...
  22. CRITICAL ROLE OF THE ASC/CASPASE-1 PATHWAY IN TICK-BORNE RICKETTSIOSES
    JOAO PEDRA; Fiscal Year: 2009
    ..The research will focus on the mechanisms of immunity against Anaplasma phagocytophilum and Rickettsia conorii, two pathogens from the tick-borne rickettsial group...
  23. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is an obligate intracellular bacterium and rickettsial pathogen that invades neutrophils and endothelial cells to cause the emerging and potentially fatal infection, human ..
  24. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is an obligate intracellular bacterial pathogen that invades neutrophils and endothelial cells to cause the emerging and potentially fatal infection, human granulocytic ..
  25. Ehrlichiacidal Mechanism in Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2011
    ..This disease is caused by Anaplasma phagocytophilum, a Gram-negative obligatory intracellular bacterium. A...
  26. Rickettsial Immunity During Tick Transmission
    JOAO PEDRA; Fiscal Year: 2013
    ..salivary protein - modulates inflammasome activation and facilitates transmission of the rickettsial pathogen Anaplasma phagocytophilum to a mammalian host...
  27. A. phagocytophilum and NF-kB signaling
    John Stephen Dumler; Fiscal Year: 2010
    Human granulocytic anaplasmosis (HGA) is tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  28. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
    ..ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum...
  29. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..MSP2 was initially defined in Anaplasma marginale and infections of cattle and ticks with this pathogen provide an excellent model for discovering the ..
  30. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    DENISE STEINLEIN; Fiscal Year: 2005
    ..This project examines the infection and coinfection prevalence of Bartonella species, Borrelia burgdorferi, and Anaplasma phagocytophilum, in field-captured rodents and ectoparasites in northern California...
  31. Immunity directed against MSP 2 during anaplasmosis
    Jeffrey Abbott; Fiscal Year: 2004
    ..Many of these agents persist in the host thus acting as potential reservoirs for further spread of disease. Anaplasma marginale is closely related genetically (16S rRNA) with E...
  32. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2007
    Human ehrlichiosis is caused by three agents including Ehrlichia chaffeensis, Anaplasma phagocytophila and by E. ewengii...
  33. Early tick salivary antigens as vaccine targets
    Sukanya Narasimhan; Fiscal Year: 2006
    ..Vaccines targeting the tick would have the advantage of blocking multiple tick-transmitted diseases. While Anaplasma phagocytophila is transmission commences after about 24 h of tick feeding, B...
  34. MALDI TOF/TOF Mass Spectrometer System for Proteomics
    James Bruce; Fiscal Year: 2006
    ..components of cellular motility (Co-Pi Cole) and proteomics investigations of immunoresponse relevant to Anaplasma maginalis (Co-Pi Brown)...
  35. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..chaffeensis virulence determinants and their pathogenic mechanisms. The results may point to potential chemotherapy, chemopreventive and/or vaccine candidates for treatment and prevention of human ehrlichiosis. ..
  36. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  37. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne infection caused by Anaplasma (Ehrlichia) phagocytophila, an obligate intracellular bacteria that infects neutrophils...
  38. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008
    ..While studies have shown that persistence of Anaplasma spp...
  39. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  40. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    Ehrlichia chaffeensis and Anaplasma phagocytophilum cause emerging infectious diseases, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), respectively...
  41. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ABSTRACT Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils...
  42. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    Research Proposal: Pathogens within the genus Anaplasma (order Rickettsiales) cause human and animal diseases including human granulocytic ehrlichiosis (HGE), equine ehrlichiosis, and bovine and ovine anaplasmosis...
  43. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    Ulrike Munderloh; Fiscal Year: 2001
    ....
  44. Granulocytic Ehrlichiosis: Cell-Pathogen Interactions
    Dori Borjesson; Fiscal Year: 2005
    ..Although Anaplasma phagocytophila, formerly the HGE agent, lives and replicates primarily within granulocytes, multiple cytopenias, ..
  45. Identifying human genes required by tick-borne pathogens
    Ulrike Munderloh; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The biology of Anaplasma phagocytophilum (Ap) and its host are intertwined...
  46. Identification of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2006
    ..It is the second most common tick-borne infection in endemic areas of the United States. HGA is caused by Anaplasma phagocytophilum, an obligate intracellular bacterium that colonizes a most unusual host cell - the neutrophil...
  47. Natural History of Borrelia lonestari
    Susan Little; Fiscal Year: 2006
    ..S., enhancing public health efforts in those areas where people are risk of infection; reduction in human disease from these pathogens should result. [unreadable] [unreadable] [unreadable] [unreadable]..
  48. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. Tyrosine phosphorylation during A. phagocytophilum invasion
    Jacob Ijdo; Fiscal Year: 2008
    ..These pathogens alter cellular processes by introducing bacterial factors into the host cell. Anaplasma phagocytophilum, which[unreadable] causes Human Granulocytic Ehrlichiosis, is a unique intracellular organism ..
  50. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2008
    ..g., Anaplasma phagocytophilum [Ap]) infect humans and their clinical correlates; and to complete the molecular and modeling ..
  51. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2002
    ..chaffeensis and other closely related organisms. ..
  52. Antigenic variation of Anaplasma marginale
    PATRICK MEEUS; Fiscal Year: 2003
    ..b>Anaplasma marginale, a bovine pathogen, is closely related to Anaplasma (Ehrlichia) phagocytophila, the causative agent of ..
  53. MOLECULAR BASIS OF PERSISTENT EHRLICHIA INFECTION
    XUE JIE YU; Fiscal Year: 2004
    ..chaffeensis. This will provide valuable information regarding the potential use of these antigens as subunit vaccines. ..
  54. Regulation of Recall Responses During Ehrlichiosis
    Gary M Winslow; Fiscal Year: 2010
    ..By defining optimal CD4 T cell immune correlates, and the role of memory CD8 T cells during recall responses, the proposed studies will contribute to the development of therapies and vaccines for ehrlichioses and related infections. ..
  55. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  56. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2007
    ..In addition, these studies will lead to a more thorough understanding of neutrophil biology, specifically he factors that regulate rac2 mRNA expression and NADPH oxidase activation. ..
  57. Blood-brain barrier traversal by African trypanosomes
    DENNIS GRAB; Fiscal Year: 2005
    ..Armed with this knowledge we will be better able to design therapies that will stop the parasites from entering the brain and prevent many of the agonizing neurological symptoms, which eventually lead to death. ..
  58. Anaplasma - B. burgorferi/endothelijm interactions
    DENNIS GRAB; Fiscal Year: 2006
    ..Human granulocytic anaplasmosis (HGA) is caused by Anaplasma phagocytophilum, a rickettsia of neutrophils that is also transmitted by the deer tick, Ixodes scapularis...
  59. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  60. American Society for Rickettsiology Conference 2006
    ROMAN GANTA; Fiscal Year: 2006
    ..abstract_text> ..
  61. Symposium on the Landscape Ecology of Infectious Disease
    MICHAEL WIMBERLY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..