anaplasma phagocytophilum

Summary

Summary: A species of gram-negative bacteria in the genus ANAPLASMA, family ANAPLASMATACEAE, formerly called Ehrlichia phagocytophila or Ehrlichia equi. This organism is tick-borne (IXODES) and causes disease in horses and sheep. In humans, it causes human granulocytic EHRLICHIOSIS.

Top Publications

  1. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
  2. pmc Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Clin Microbiol Rev 24:469-89. 2011
  3. pmc Multiplex real-time PCR for detection of anaplasma phagocytophilum and Borrelia burgdorferi
    Joshua W Courtney
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 13, Atlanta, GA 30333, USA
    J Clin Microbiol 42:3164-8. 2004
  4. ncbi The natural history of Anaplasma phagocytophilum
    Zerai Woldehiwet
    University of Liverpool, Department of Veterinary Pathology, Veterinary Teaching Hospital, Leahurst, Neston, South Wirral CH64 7TE, UK
    Vet Parasitol 167:108-22. 2010
  5. ncbi Identification of Anaplasma phagocytophilum in tick populations in Estonia, the European part of Russia and Belarus
    O Katargina
    National Institute for Health Development, Tallinn, Estonia
    Clin Microbiol Infect 18:40-6. 2012
  6. pmc Prevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in questing Ixodes ricinus ticks in relation to the density of wild cervids
    Olav Rosef
    Telemark University College, Bø i Telemark, Norway
    Acta Vet Scand 51:47. 2009
  7. pmc Tick-borne zoonotic bacteria in wild and domestic small mammals in northern Spain
    J F Barandika
    NEIKER, Instituto Vasco de Investigación y Desarrollo Agrario, 48160 Derio Bizkaia, Spain
    Appl Environ Microbiol 73:6166-71. 2007
  8. pmc Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 12:1213-21. 2010
  9. ncbi Epidemiology and control of human granulocytic anaplasmosis: a systematic review
    Hongtao Jin
    Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin Province, People s Republic of China
    Vector Borne Zoonotic Dis 12:269-74. 2012
  10. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003

Detail Information

Publications256 found, 100 shown here

  1. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
    Ehrlichia chaffeensis and Anaplasma phagocytophilum are agents of human monocytic and granulocytic ehrlichioses, respectively. They are extremely sensitive to mechanical stress and are pleomorphic gram-negative bacteria...
  2. pmc Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Clin Microbiol Rev 24:469-89. 2011
    b>Anaplasma phagocytophilum persists in nature by cycling between mammals and ticks. Human infection by the bite of an infected tick leads to a potentially fatal emerging disease called human granulocytic anaplasmosis. A...
  3. pmc Multiplex real-time PCR for detection of anaplasma phagocytophilum and Borrelia burgdorferi
    Joshua W Courtney
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 13, Atlanta, GA 30333, USA
    J Clin Microbiol 42:3164-8. 2004
    A multiplex real-time PCR assay was developed for the simultaneous detection of Anaplasma phagocytophilum and Borrelia burgdorferi...
  4. ncbi The natural history of Anaplasma phagocytophilum
    Zerai Woldehiwet
    University of Liverpool, Department of Veterinary Pathology, Veterinary Teaching Hospital, Leahurst, Neston, South Wirral CH64 7TE, UK
    Vet Parasitol 167:108-22. 2010
    b>Anaplasma phagocytophilum is the recently designated name replacing three species of granulocytic bacteria, Ehrlichia phagocytophila, Ehrlichia equi and the agent of human granulocytic ehrlichiosis, after the recent reorganization of the ..
  5. ncbi Identification of Anaplasma phagocytophilum in tick populations in Estonia, the European part of Russia and Belarus
    O Katargina
    National Institute for Health Development, Tallinn, Estonia
    Clin Microbiol Infect 18:40-6. 2012
    b>Anaplasma phagocytophilum is associated with diseases of goats, sheep, cattle, dogs and horses...
  6. pmc Prevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in questing Ixodes ricinus ticks in relation to the density of wild cervids
    Olav Rosef
    Telemark University College, Bø i Telemark, Norway
    Acta Vet Scand 51:47. 2009
    Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum have been considered as pathogens in animals and humans. The role of wild cervids in the epidemiology is not clear...
  7. pmc Tick-borne zoonotic bacteria in wild and domestic small mammals in northern Spain
    J F Barandika
    NEIKER, Instituto Vasco de Investigación y Desarrollo Agrario, 48160 Derio Bizkaia, Spain
    Appl Environ Microbiol 73:6166-71. 2007
    The prevalence and diversity of tick-borne zoonotic bacteria (Borrelia spp., Anaplasma phagocytophilum, Coxiella burnetii, and spotted fever group rickettsiae) infecting 253 small mammals captured in the Basque Country (Spain) were ..
  8. pmc Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 12:1213-21. 2010
    b>Anaplasma phagocytophilum is an obligatory intracellular bacterium that infects neutrophils, the primary host defence cells...
  9. ncbi Epidemiology and control of human granulocytic anaplasmosis: a systematic review
    Hongtao Jin
    Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin Province, People s Republic of China
    Vector Borne Zoonotic Dis 12:269-74. 2012
    Granulocytic anaplasmosis caused by Anaplasma phagocytophilum is an emerging tick-borne zoonosis worldwide...
  10. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
    ..67%) Ixodes pacificus ticks and in 3 of 58 (5.17%) Dermacentor variabilis ticks. Anaplasma phagocytophilum, the causative agent of HGE, was detected by PCR in 48 (6.19%) I. pacificus ticks and 5 (8.62%) D...
  11. ncbi Questing ticks in suburban forest are infected by at least six tick-borne pathogens
    Caroline Reis
    USC INRA Bartonella Tiques, Anses, Maisons Alfort Cedex, France
    Vector Borne Zoonotic Dis 11:907-16. 2011
    ..burgdorferi s.l. (32% of adult females and 10% of nymphs) and low to moderate ones of Anaplasma phagocytophilum (~1%), spotted fever group Rickettsia spp. (~6%), Babesia sp. EU1 (~1%), Bartonella birtlesii (0...
  12. pmc Prevalence and seasonality of tick-borne pathogens in questing Ixodes ricinus ticks from Luxembourg
    Anna L Reye
    Institute of Immunology, National Public Health Laboratory CRP Santé, Luxembourg, Luxembourg
    Appl Environ Microbiol 76:2923-31. 2010
    ..3% for Borrelia burgdorferi sensu lato, 5.1% for Rickettsia sp., 2.7% for Babesia sp., and 1.9% for Anaplasma phagocytophilum. No tick was found to be infected with Coxiella sp., Francisella tularensis subsp...
  13. pmc Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters
    Wiebke Scharf
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 49:790-6. 2011
    b>Anaplasma phagocytophilum is a gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals...
  14. pmc Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold
    Girish Neelakanta
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8022, USA
    J Clin Invest 120:3179-90. 2010
    ..overwinter in the Northeast and Upper Midwest and transmit the agent of human granulocytic anaplasmosis, Anaplasma phagocytophilum, among other pathogens. We now show that the presence of A. phagocytophilum in I...
  15. ncbi Pathogens and symbionts in ticks: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp., Rickettsia sp., and Babesia sp. in Southern Germany
    Kathrin Hartelt
    Baden Wuerttemberg State Health Office, Stuttgart, Germany
    Int J Med Microbiol 293:86-92. 2004
    ..research now gives an additional focus to a broad range of other bacteria and parasites in ticks like Anaplasma phagocytophilum, former Ehrlichia sp., Rickettsia sp. and Babesia sp...
  16. pmc Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks
    Hameeda Sultana
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 207:1727-43. 2010
    b>Anaplasma phagocytophilum, the agent of human anaplasmosis, persists in ticks and mammals. We show that A...
  17. pmc Tickborne pathogen detection, Western Siberia, Russia
    Vera A Rar
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch Russian Academy of Sciences, Lavrentyev s Avenue 8, 630090 Novosibirsk, Russia
    Emerg Infect Dis 11:1708-15. 2005
    ..6% +/- 4.3% [standard deviation]), Anaplasma phagocytophilum (2.4% +/- 1.4%), Ehrlichia muris (8.8% +/- 2.5%), and Bartonella spp. (37.6% +/- 4.3%). D...
  18. ncbi Prevalence of Anaplasma phagocytophilum in Ixodes ricinus in Bavarian public parks, Germany
    Sabine Schorn
    Comparative Tropical Medicine and Parasitology, Ludwig Maximilians University, Munich, Germany
    Ticks Tick Borne Dis 2:196-203. 2011
    ..this study was to investigate the tick abundance (ticks/100 m(2)) in urban areas and the prevalence of Anaplasma phagocytophilum. Collection of ticks was performed by the flagging method in selected Bavarian public parks in a 2-year ..
  19. ncbi Isolation, propagation and preliminary characterisation of Anaplasma phagocytophilum from roe deer (Capreolus capreolus) in the tick cell line IDE8
    Cornelia Silaghi
    Institute for Comparative Tropical Medicine and Parasitology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Ticks Tick Borne Dis 2:204-8. 2011
    b>Anaplasma phagocytophilum is an obligate intracellular bacterium causing granulocytic anaplasmosis in dogs, horses, and humans and tick-borne fever of ruminants...
  20. ncbi Prevalence of Anaplasma phagocytophilum and coinfection with Borrelia burgdorferi sensu lato in the hard tick Ixodes ricinus in the city of Hanover (Germany)
    Sabine Schicht
    Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany
    Vector Borne Zoonotic Dis 11:1595-7. 2011
    ..bean tick Ixodes ricinus has been found to be the main vector for Lyme borreliosis spirochetes and Anaplasma phagocytophilum in Central Europe. 1646 I...
  21. ncbi The clinical characteristics and outcomes of patients with human granulocytic anaplasmosis in China
    Huiyu Li
    Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Int J Infect Dis 15:e859-66. 2011
    ..granulocytic anaplasmosis (HGA), a tick-borne disease caused by the obligate intracellular bacterium Anaplasma phagocytophilum, has increased across the world. However, information on HGA is lacking in China...
  22. pmc Prevalence of tick-borne pathogens in Ixodes ricinus and Dermacentor reticulatus ticks from different geographical locations in Belarus
    Anna L Reye
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
    PLoS ONE 8:e54476. 2013
    ..4%). Pathogens with low prevalence rates in ticks were Anaplasma phagocytophilum (2.2%), Coxiella burnetii (0.9%), Francisella tularensis subspecies (0.7%), Bartonella henselae (0...
  23. pmc Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles
    Kevin J Bown
    University of Liverpool, Liverpool, UK
    Emerg Infect Dis 15:1948-54. 2009
    The emerging tick-borne pathogen Anaplasma phagocytophilum is under increasing scrutiny for the existence of subpopulations that are adapted to different natural cycles. Here, we characterized the diversity of A...
  24. pmc Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice
    Juliana E Mastronunzio
    Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    J Bacteriol 194:2238-47. 2012
    ..Here we apply proteomics and transcriptome sequencing to Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis, in Ixodes scapularis tick salivary glands, to detect ..
  25. ncbi Investigation of Anaplasma phagocytophila infections in Ixodes ricinus and Dermacentor reticulatus ticks in Austria
    Wolfdieter Sixl
    Institute of Hygiene, University of Graz, Graz, Austria
    Ann N Y Acad Sci 990:94-7. 2003
  26. ncbi Molecular detection of Anaplasma phagocytophilum in the European hedgehog (Erinaceus europaeus) and its ticks
    Jasmin Skuballa
    Department of Ecology and Parasitology, Zoological Institute, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Vector Borne Zoonotic Dis 10:1055-7. 2010
    ..Thus, this species may play a role in human contact with zoonotic diseases. Here we report the presence of the pathogen Anaplasma phagocytophilum in hedgehogs and their ticks in Germany.
  27. pmc Rapid, simple, and sensitive detection of Anaplasma phagocytophilum by loop-mediated isothermal amplification of the msp2 gene
    Lei Pan
    Department of Rickettsiology, National Institute of Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, People s Republic of China
    J Clin Microbiol 49:4117-20. 2011
    b>Anaplasma phagocytophilum is the causative agent of human granulocytic anaplasmosis, which is prevalent throughout China...
  28. pmc Tick-borne agents in rodents, China, 2004-2006
    Lin Zhan
    Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    Emerg Infect Dis 15:1904-8. 2009
    ..and autonomous regions of mainland People's Republic of China were tested by PCRs for tick-borne agents (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, spotted fever group rickettsiae, and Francisella tularensis)...
  29. pmc Babesia spp. and Anaplasma phagocytophilum in questing ticks, ticks parasitizing rodents and the parasitized rodents--analyzing the host-pathogen-vector interface in a metropolitan area
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Parasit Vectors 5:191. 2012
    The aims of this study were to evaluate the host-tick-pathogen interface of Babesia spp. and Anaplasma phagocytophilum in restored areas in both questing and host-attached Ixodes ricinus and Dermacentor reticulatus and their small ..
  30. ncbi Epidemiological, clinical and laboratory characteristics of patients with human granulocytic anaplasmosis in Slovenia
    Stanka Lotric-Furlan
    Department of Infectious Diseases, University Medical Center Ljubljana, University of Ljubljana, Slovenia
    Wien Klin Wochenschr 118:708-13. 2006
    ..Several reports indicate the presence of infection with Anaplasma phagocytophilum in Europe...
  31. ncbi Anaplasma spp. in wild mammals and Ixodes ricinus from the north of Spain
    Aranzazu Portillo
    Área de Enfermedades Infecciosas Centro de Rickettsiosis y Enfermedades Transmitidas por Artrópodos Vectores, Hospital San Pedro CIBIR, Logrono, Spain
    Vector Borne Zoonotic Dis 11:3-8. 2011
    ..Twelve deer blood samples were found to be infected with Anaplasma centrale (n = 7) or Anaplasma phagocytophilum (n = 5). No wild boar blood samples gave positive polymerase chain reaction results. Further, A...
  32. ncbi First report of Anaplasma phagocytophilum and its co-infections with Borrelia burgdorferi sensu lato in Ixodes ricinus ticks (Acari: Ixodidae) from Republic of Moldova
    Juraj Koci
    Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava 84245, Slovakia
    Exp Appl Acarol 41:147-52. 2007
    ..198 questing Ixodes ricinus ticks collected in Chisinau City, Republic of Moldova by PCR assays for Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and co-infection of both pathogens, which were detected in 9%, 25...
  33. pmc Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007
    F Scott Dahlgren
    Division of Vectorborne Infectious Diseases, National Center for Enteric, Zoonotic, and Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 85:124-31. 2011
    Ehrlichia chaffeensis causes human monocytic ehrlichiosis, and Anaplasma phagocytophilum causes human granulocytic anaplasmosis. These related tick-borne rickettsial organisms can cause severe and fatal illness...
  34. pmc Sequence analysis of the msp4 gene of Anaplasma phagocytophilum strains
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    J Clin Microbiol 43:1309-17. 2005
    The causative agent of human granulocytic ehrlichiosis was recently reclassified as Anaplasma phagocytophilum, unifying previously described bacteria that cause disease in humans, horses, dogs, and ruminants...
  35. ncbi Expression of heat shock proteins and subolesin affects stress responses, Anaplasma phagocytophilum infection and questing behaviour in the tick, Ixodes scapularis
    A T Busby
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, U S A
    Med Vet Entomol 26:92-102. 2012
    ..scapularis Say (Acari: Ixodidae) stress responses to heat shock and feeding, questing behaviour and Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae) infection...
  36. ncbi Anaplasma phagocytophilum groEL gene heterogeneity in Ixodes ricinus larvae feeding on roe deer in Northeastern Italy
    Giovanna Carpi
    Centre for Alpine Ecology, Edmund Mach Foundation, Trento, Italy
    Vector Borne Zoonotic Dis 9:179-84. 2009
    b>Anaplasma phagocytophilum is an emerging tick-borne pathogen with both veterinary and human health implications...
  37. pmc Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Microbiol 12:1222-34. 2010
    ..Thus, we used the tick-borne bacterium Anaplasma phagocytophilum- the agent of human granulocytic anaplasmosis to understand these processes. Here we show that A...
  38. ncbi Nosocomial transmission of human granulocytic anaplasmosis in China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, China, CDC, Beijing, China, PO Box 5, Changping, Beijing, China 102206
    JAMA 300:2263-70. 2008
    ..A cluster of cases among health care workers and family members following exposure to a patient with fulminant disease consistent with HGA prompted investigation...
  39. pmc An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands
    Bindu Sukumaran
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 203:1507-17. 2006
    b>Anaplasma phagocytophilum is the agent of human anaplasmosis, the second most common tick-borne illness in the United States...
  40. ncbi Prevalence and geographic distribution of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in dogs in the United States: results of a national clinic-based serologic survey
    Dwight Bowman
    Department of Microbiology and Immunology, Cornell College of Veterinary Medicine, C4 119 Veterinary Medical Center, Ithaca, NY 14853, United States
    Vet Parasitol 160:138-48. 2009
    ..to, four vector-borne disease agents, Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in order to assess geographic trends in rates of positive tests...
  41. ncbi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
    Anaplasma spp. and Ehrlichia spp. cause several emerging human infectious diseases. Anaplasma phagocytophilum and Ehrlichia chaffeensis are transmitted between mammals by blood-sucking ticks and replicate inside mammalian white blood ..
  42. pmc Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Appl Environ Microbiol 74:7118-25. 2008
    ..ricinus and I. trianguliceps in the transmission of Anaplasma phagocytophilum and Babesia microti among United Kingdom field voles (Microtus agrestis), which serve as reservoir hosts ..
  43. pmc High diversity of ankA sequences of Anaplasma phagocytophilum among Ixodes ricinus ticks in Germany
    Friederike D von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, Germany
    J Clin Microbiol 41:5033-40. 2003
    ..Here, we characterized three different genes of Anaplasma phagocytophilum strains infecting German Ixodes ricinus ticks in order to test whether they differ from strains in other ..
  44. ncbi A study of the presence of B. burgdorferi, Anaplasma (previously Ehrlichia) phagocytophilum, Rickettsia, and Babesia in Ixodes ricinus collected within the territory of Belluno, Italy
    G Piccolin
    Observatory for the Study, Surveillance and Prevention of Tick Borne Diseases, ULSS, Veneto, Belluno, Italy
    Vector Borne Zoonotic Dis 6:24-31. 2006
    ..4% were positive for Ehrlichia, 1.6% were positive for Rickettsia, and 1.6% were positive for Babesia. The co-presence of Borrelia and Ehrlichia (1.2%) and Babesia (0.5%), Borrelia, Ehrlichia and Rickettsia (0.1%) was also found...
  45. ncbi Anaplasma phagocytophilum seroprevalence in equids: a survey in Sicily (Italy)
    Elisabetta Giudice
    Dipartimento di Sanità Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Messina, Polo Universitario dell Annunziata, 98168 Messina, Italy
    Parasitol Res 111:951-5. 2012
    This study was undertaken to determine the prevalence of Anaplasma phagocytophilum infection in Equidae and investigate the possibility of exposure to the organism in Sicily (Southern Italy)...
  46. pmc Correlation between tick density and pathogen endemicity, New Hampshire
    Seth T Walk
    University of Massachusetts, Amherst, Massachusetts, USA
    Emerg Infect Dis 15:585-7. 2009
    ..Pathogens were more prevalent in areas of high tick density, suggesting a correlation between tick establishment and pathogen endemicity. Infection rates in ticks correlated with disease frequency in humans...
  47. ncbi Experimental infection of C3H/HeJ mice with the NY18 isolate of Anaplasma phagocytophilum
    U Blas-Machado
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA
    Vet Pathol 44:64-73. 2007
    ..HGA), an emerging disease of public health concern in many areas of the world, is caused by Anaplasma phagocytophilum. Small animal models of A phagocytophilum in laboratory mice have been developed and used to study the ..
  48. ncbi Molecular evidence for persistence of Anaplasma phagocytophilum in the absence of clinical abnormalities in horses after recovery from acute experimental infection
    P Franzen
    Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Vet Intern Med 23:636-42. 2009
    b>Anaplasma phagocytophilum infects several mammalian species, and can persist in sheep, dogs, and calves. However, whether this organism persists in horses or induces long-term clinical abnormalities is not known.
  49. ncbi The common shrew (Sorex araneus): a neglected host of tick-borne infections?
    Kevin J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Vector Borne Zoonotic Dis 11:947-53. 2011
    ..Of 647 blood samples collected from shrews, 121 (18.7%) showed evidence of infection with Anaplasma phagocytophilum and 196 (30.3%) with Babesia microti. By comparison, of 1505 blood samples from field voles, 96 (6...
  50. pmc Role of the lizard Teira dugesii as a potential host for Ixodes ricinus tick-borne pathogens
    R De Sousa
    National Institute of Health Dr Ricardo Jorge, Aguas de Moura, Portugal
    Appl Environ Microbiol 78:3767-9. 2012
    ....
  51. ncbi Prevalence of Rickettsia spp., Anaplasma phagocytophilum, and Coxiella burnetii in adult Ixodes ricinus ticks from 29 study areas in central and southern Sweden
    Katarina Wallménius
    Unit of Clinical Bacteriology, Dept of Medical Sciences, Uppsala University, Uppsala, Sweden
    Ticks Tick Borne Dis 3:100-6. 2012
    ..Coxiella burnetii DNA was not detected in any of the ticks. The detection of R. helvetica and A. phagocytophilum in several of the localities sampled suggests that these potentially human-pathogenic agents are common in Sweden...
  52. pmc Anaplasma phagocytophilum: deceptively simple or simply deceptive?
    Maiara S Severo
    Department of Entomology and Center for Disease Vector Research, 900 University Avenue, University of California Riverside, Riverside, CA 92521, USA
    Future Microbiol 7:719-31. 2012
    b>Anaplasma phagocytophilum is an obligate intracellular rickettsial pathogen transmitted by ixodid ticks...
  53. pmc Genetic variants of Anaplasma phagocytophilum from 14 equine granulocytic anaplasmosis cases
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Faculty of Veterinary Medicine, Ludwig Maximilians Universitat, Leopoldstr, 5, 80802 Munich, Germany
    Parasit Vectors 4:161. 2011
    Equine Granulocytic Anaplasmosis (EGA) is caused by Anaplasma phagocytophilum, a tick-transmitted, obligate intracellular bacterium. In Europe, it is transmitted by Ixodes ricinus. A large number of genetic variants of A...
  54. ncbi The potential role of migratory birds in transmission cycles of Babesia spp., Anaplasma phagocytophilum, and Rickettsia spp
    Anke Hildebrandt
    Institute of Medical Microbiology, Medical University Laboratories, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Thuringia, Germany
    Ticks Tick Borne Dis 1:105-7. 2010
    Babesia spp., Anaplasma phagocytophilum, and Rickettsia spp. are potentially emerging tick-borne pathogens, whereas many issues about their ecology, e.g. reservoir host specificity, are still unclear...
  55. ncbi Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species
    Toshiyuki Masuzawa
    Laboratory of Microbiology and Immunology, Faculty of Pharmacy, Chiba Institute of Science CIS, Choshi 288 0025, Japan
    J Med Microbiol 57:986-91. 2008
    ..granulocytic anaplasmosis (HGA) and Lyme borreliosis (LB) are tick-borne infectious diseases caused by Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato species, respectively...
  56. pmc Anaplasma phagocytophilum infection in small mammal hosts of Ixodes ticks, western United States
    Janet E Foley
    University of California, Davis, California, USA
    Emerg Infect Dis 14:1147-50. 2008
    A total of 2,121 small mammals in California were assessed for Anaplasma phagocytophilum from 2006 through 2008. Odds ratios were >1 for 4 sciurids species and dusky-footed woodrats. High seroprevalence was observed in northern sites...
  57. ncbi Anaplasma phagocytophilum in livestock and small rodents
    Lin Zhan
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong Da Street, Fengtai District, Beijing 100071, People s Republic of China
    Vet Microbiol 144:405-8. 2010
    To identify the prevalence of Anaplasma phagocytophilum in both wild rodents and domestic animals and to make clear the genetic characteristics of the agents from different animals in China, a total of 105 livestock and 159 small rodents ..
  58. ncbi Cultivation of an ovine strain of Ehrlichia phagocytophila in tick cell cultures
    Z Woldehiwet
    Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool, L69 3BX, UK
    J Comp Pathol 127:142-9. 2002
    ..phagocytophila. A susceptible sheep inoculated with a third passage of the tick cell-adapted E. phagocytophila reacted with fever and rickettsiaemia 5 days later, thus satisfying Koch's postulates...
  59. pmc Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function
    Venetta Thomas
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Infect Immun 76:4905-12. 2008
    b>Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis, is an unusual obligate intracellular pathogen that persists in neutrophils. A...
  60. pmc Coexistence of pathogens in host-seeking and feeding ticks within a single natural habitat in Central Germany
    Jan Franke
    Department of Food and Environmental Hygiene, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 29, 07743 Jena, Germany
    Appl Environ Microbiol 76:6829-36. 2010
    ..their natural transmission cycles, the ticks were tested for the presence of Lyme disease borreliae, Anaplasma phagocytophilum, spotted fever group (SFG) rickettsiae, Francisella tularensis, and babesiae. Altogether, 20...
  61. ncbi Inoculation of white-tailed deer (Odocoileus virginianus) with Ap-V1 Or NY-18 strains of Anaplasma phagocytophilum and microscopic demonstration of Ap-V1 In Ixodes scapularis adults that acquired infection from deer as nymphs
    Mason V Reichard
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Vector Borne Zoonotic Dis 9:565-8. 2009
    Four white-tailed deer were inoculated with either the Ap-V1 or NY-18 strain of Anaplasma phagocytophilum. Ixodes scapularis nymphs were then allowed to acquistion feed on the inoculated deer and molt to adults...
  62. ncbi Established and emerging pathogens in Ixodes ricinus ticks collected from birds on a conservation island in the Baltic Sea
    J Franke
    Department of Food and Environmental Hygiene, Institute of Nutrition, Friedrich Schiller University of Jena, Jena, Germany
    Med Vet Entomol 24:425-32. 2010
    Tick-borne pathogens such as Lyme borreliosis spirochaetes, Anaplasma phagocytophilum, Rickettsia spp. and Babesia spp. cause a great variety of diseases in animals and humans...
  63. ncbi Longitudinal field study on bovine Babesia spp. and Anaplasma phagocytophilum infections during a grazing season in Belgium
    Laetitia Lempereur
    Laboratory of Parasitology and Parasitic Diseases, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
    Parasitol Res 110:1525-30. 2012
    ..7%, 20%, and 12.3% in spring, summer, and autumn, respectively, whereas seroprevalences to Anaplasma phagocytophilum were 30.8%, 77%, and 56.9%, respectively...
  64. ncbi Pathogens of emerging tick-borne diseases, Anaplasma phagocytophilum, Rickettsia spp., and Babesia spp., in ixodes ticks collected from rodents at four sites in Switzerland (Canton of Bern)
    Caroline Burri
    Laboratory of Eco Epidemiology of Parasites, Institute of Biology, University of Neuchatel, Neuchatel, Switzerland
    Vector Borne Zoonotic Dis 11:939-44. 2011
    ..Here we focused on the detection of three intracellular pathogens, Anaplasma phagocytophilum, Rickettsia spp., and Babesia spp., in field-derived ticks that detached from 79 small mammals...
  65. ncbi A survey on Anaplasma phagocytophila in wild small mammals and roe deer (Capreolus capreolus) in Northern Spain
    Beatriz Oporto
    NEIKER, Departamento Sanidad Animal, Berreaga 1, 48160 Derio, Bizkaia, Spain
    Ann N Y Acad Sci 990:98-102. 2003
  66. pmc Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Infect Immun 71:4586-94. 2003
    b>Anaplasma phagocytophilum propagates within neutrophils and causes a disease marked by inflammatory tissue injury or complicated by opportunistic infections. We hypothesized that infection with A...
  67. pmc Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Curr Opin Microbiol 13:59-66. 2010
    ..Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the host cytoplasm via a complex that includes VirD4...
  68. ncbi Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan
    - Gaowa
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, Global Center of Excellence Program, University of Shizuoka, Shizuoka, Japan
    Jpn J Infect Dis 65:79-83. 2012
    b>Anaplasma phagocytophilum is an obligate intracellular bacterium and causes a febrile illness in humans and livestock. In nature, this bacterium is sustained in a tick-mammal cycle...
  69. ncbi Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia
    Y M'Ghirbi
    Service d Entomologie Médicale, Institut Pasteur de Tunis, 1002 Tunis, Tunisia
    Parasitol Res 104:767-74. 2009
    ..in five bioclimatic areas of Tunisia to determine the prevalence of antibodies to Ehrlichia canis and Anaplasma phagocytophilum antigens, surrogate markers of the agents of canine monocytic ehrlichiosis (CME) and canine granulocytic ..
  70. pmc The biological basis of severe outcomes in Anaplasma phagocytophilum infection
    J Stephen Dumler
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEMS Immunol Med Microbiol 64:13-20. 2012
    b>Anaplasma phagocytophilum causes granulocytic anaplasmosis, an acute disease in humans that is also often subclinical. However, 36% are hospitalized, 7% need intensive care, and the case fatality rate is 0.6%...
  71. ncbi Molecular evidence for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from eastern Slovakia
    Marketa Derdakova
    Faculty of Medicine, P J Safarik University, Srobarova 2, 041 80 Kosice, Slovak Republic
    Ann Agric Environ Med 10:269-71. 2003
    ..20 males, 20 females and 20 nymphs) collected in Kosice, Slovakia were examined for the presence of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato (s.l.) by PCR. 38...
  72. ncbi Detection of Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus ticks in a region of Middle Germany (Thuringia)
    Anke Hildebrandt
    Institute of Medical Microbiology, Medical University Laboratories, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Ticks Tick Borne Dis 1:52-6. 2010
    ..and the 16S rRNA gene of Anaplasma phagocytophilum. Positive amplicons were identified with restriction fragment length polymorphism (RFLP) and/or ..
  73. ncbi Genetic variants of Anaplasma phagocytophilum in wild caprine and cervid ungulates from the Alps in Tyrol, Austria
    Cornelia Silaghi
    Faculty of Veterinary Medicine and Parasitology, Institute of Comparative Tropical Medicine and Parasitology, Ludwig Maximilians University, Leopoldstrasse 5, Munich, Germany
    Vector Borne Zoonotic Dis 11:355-62. 2011
    The occurrence of genetic variants of Anaplasma phagocytophilum was studied in wild ungulates from the northern and central eastern Alps in Tyrol, Austria...
  74. ncbi Isolation of Anaplasma phagocytophilum strain Ap-variant 1 in a tick-derived cell line
    Robert F Massung
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 13, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1078:541-4. 2006
    Ten isolates of the Ap-Variant 1 strain of Anaplasma phagocytophilum were made in the Ixodes scapularis (I. scapularis)-derived cell line, ISE6...
  75. pmc Wild boars as hosts of human-pathogenic Anaplasma phagocytophilum variants
    Jerzy Michalik
    Department of Animal Morphology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland
    Emerg Infect Dis 18:998-1001. 2012
    To investigate the potential of wild boars to host Anaplasma phagocytophilum, we analyzed bacterial 16S rRNA and ank genes. DNA sequencing identified several A...
  76. pmc Anaplasma phagocytophilum, Sardinia, Italy
    Alberto Alberti
    Emerg Infect Dis 11:1322-4. 2005
  77. ncbi Occurrence of Dirofilaria immitis and tick-borne infections caused by Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis in domestic dogs in France: results of a countrywide serologic survey
    Nikola Pantchev
    Vet Med Labor GmbH, Division of IDEXX Laboratories, Ludwigsburg, Germany
    Parasitol Res 105:S101-14. 2009
    ..Samples in group A were also tested for specific antibodies against three tick-borne pathogens (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis). Results were plotted in geographical maps...
  78. pmc Anaplasma phagocytophilum from Rodents and Sheep, China
    Lin Zhan
    Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    Emerg Infect Dis 16:764-8. 2010
    To characterize the strains of Anaplasma phagocytophilum in wild and domestic animals in China, we isolated the organism from rodents and sheep in northeastern China...
  79. pmc Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction
    Hua Niu
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA
    PLoS Pathog 6:e1000774. 2010
    b>Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, infects human neutrophils and inhibits mitochondria-mediated apoptosis. Bacterial factors involved in this process are unknown...
  80. ncbi A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in Germany
    F D Von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3 5, 91054, Erlangen, Germany
    Eur J Clin Microbiol Infect Dis 22:303-5. 2003
    ..Thus, the current lack of clinical cases of HGE in Germany is unlikely to result from the absence of pathogenic granulocytic ehrlichiae strains in German ticks...
  81. ncbi Performance of a commercially available in-clinic ELISA for the detection of antibodies against Anaplasma phagocytophilum, Ehrlichia canis, and Borrelia burgdorferi and Dirofilaria immitis antigen in dogs
    Ramaswamy Chandrashekar
    Immunoassay R and D, IDEXX Laboratories, 1 IDEXX Dr, Westbrook, ME 04092, USA
    Am J Vet Res 71:1443-50. 2010
    ..To evaluate the sensitivity and specificity of a commercially available in-clinic ELISA for detection of heartworm infection and tick-borne diseases in dogs...
  82. pmc Anaplasma phagocytophilum AptA modulates Erk1/2 signalling
    Bindu Sukumaran
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8022, USA
    Cell Microbiol 13:47-61. 2011
    b>Anaplasma phagocytophilum causes human granulocytic anaplasmosis, one of the most common tick-borne diseases in North America. This unusual obligate intracellular pathogen selectively persists within polymorphonuclear leucocytes...
  83. ncbi Coincidence of three pathogens (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti) in Ixodes ricinus ticks in the Lublin macroregion
    Angelina Wójcik-Fatla
    Department of Occupational Biohazards, Institute of Agricultural Medicine, Lublin, Poland
    Ann Agric Environ Med 16:151-8. 2009
    ..The aim of the study was to determine the coincidence of 3 pathogens: Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in Ixodes ricinus ticks in south-eastern Poland and to estimate the degree of ..
  84. ncbi Detection of Anaplasma phagocytophilum in Amblyomma flavomaculatum ticks (Acari: Ixodidae) collected from lizard Varanus exanthematicus imported to Poland
    Magdalena Nowak
    Department of Invertebrate Zoology and Parasitology, Institute of Biology, Pedagogical University of Cracow, Krakow, Poland
    Exp Appl Acarol 51:363-71. 2010
    ..None of the tested ticks was positive for the gltA gene of Rickettsia spp. DNA of 16S rRNA gene from Anaplasma phagocytophilum was amplified and sequenced from two adult A...
  85. pmc Variant -and individual dependent nature of persistent Anaplasma phagocytophilum infection
    Erik G Granquist
    Department of Production Animal Clinical Sciences, Section of Small Ruminant Research, Norwegian School of Veterinary Science, Sandnes, N 4325, Norway
    Acta Vet Scand 52:25. 2010
    b>Anaplasma phagocytophilum is the causative agent of tick-borne fever in ruminants and human granulocytotropic anaplasmosis (HGA)...
  86. ncbi Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests
    Joanna Stanczak
    Medical University of Gdansk, Interfaculty Institute of Maritime and Tropical Medicine, 9B Powstania Styczniowego str, 81 519 Gdynia, Poland
    Ann Agric Environ Med 11:109-14. 2004
    ..agents of Lyme disease, human anaplasmosis (HA) and babesiosis: Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti, respectively...
  87. pmc Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions
    Quan Lin
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1093, USA
    Infect Immun 72:5574-81. 2004
    A polymorphic multigene family (p44) of Anaplasma phagocytophilum encodes the immunodominant 44-kDa major outer membrane proteins...
  88. pmc Anaplasma phagocytophilum infection in Ixodes ricinus, Bavaria, Germany
    Cornelia Silaghi
    Ludwig Maximilians University, Munich, Germany
    Emerg Infect Dis 14:972-4. 2008
    b>Anaplasma phagocytophilum DNA was detected by real-time PCR, which targeted the msp2 gene, in 2...
  89. pmc Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane
    Bernice Huang
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0678, USA
    Microb Pathog 49:273-84. 2010
    b>Anaplasma phagocytophilum infects neutrophils and myeloid, endothelial, and tick cell lines to reside within a host cell-derived vacuole that is indispensible for its survival...
  90. pmc Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection
    Jason A Carlyon
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 72:4772-83. 2004
    b>Anaplasma phagocytophilum, the etiologic agent of human anaplasmosis, is a bacterial pathogen that specifically colonizes neutrophils...
  91. pmc Porin activity of Anaplasma phagocytophilum outer membrane fraction and purified P44
    Haibin Huang
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 189:1998-2006. 2007
    b>Anaplasma phagocytophilum, an obligatory intracellular bacterium that causes human granulocytic anaplasmosis, has significantly less coding capacity for biosynthesis and central intermediary metabolism than do free-living bacteria...
  92. pmc Expression of multiple outer membrane protein sequence variants from a single genomic locus of Anaplasma phagocytophilum
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, PO Box 110880, Gainesville, FL 32611, USA
    Infect Immun 71:1706-18. 2003
    b>Anaplasma phagocytophilum is the causative agent of an emerging tick-borne zoonosis in the United States and Europe...
  93. pmc Mechanisms of variable p44 expression by Anaplasma phagocytophilum
    Quan Lin
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Infect Immun 71:5650-61. 2003
    The human intragranulocytic bacterium Anaplasma phagocytophilum promotes variation of P44s, which are surface-exposed proteins encoded by a p44 multigene family...
  94. ncbi Spatial distribution of seroprevalence for Anaplasma phagocytophilum, Borrelia burgdorferi, Ehrlichia canis, and Dirofilaria immitis in dogs in Washington, Oregon, and California
    Danielle Carrade
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Vet Clin Pathol 40:293-302. 2011
    ..In the US little spatially defined information regarding exposure to most vector-borne pathogens in dogs is available for the states of California (CA), Oregon (OR), and Washington (WA)...
  95. ncbi Infections of wild animals with Anaplasma phagocytophila in Austria and the Czech Republic
    Miroslav Petrovec
    Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Ann N Y Acad Sci 990:103-6. 2003
  96. ncbi Prevalence of seropositivity to spotted fever group rickettsiae and Anaplasma phagocytophilum in a large, demographically diverse US sample
    Paul C F Graf
    Viral and Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
    Clin Infect Dis 46:70-7. 2008
    ..Most epidemiologic studies of tick-borne rickettsial diseases in the United States are small and have limited demographic scope, making broader risk assessment difficult...
  97. ncbi Prevalence of Bartonella species, haemoplasma species, Ehrlichia species, Anaplasma phagocytophilum, and Neorickettsia risticii DNA in the blood of cats and their fleas in the United States
    Michael R Lappin
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Feline Med Surg 8:85-90. 2006
    ..were digested and assessed in polymerase chain reaction assays that amplify DNA of Ehrlichia species, Anaplasma phagocytophilum, Neorickettsia risticii, Mycoplasma haemofelis, 'Candidatus M haemominutum' and Bartonella species...
  98. ncbi Use of imidacloprid-permethrin to prevent transmission of Anaplasma phagocytophilum from naturally infected Ixodes scapularis ticks to dogs
    Byron L Blagburn
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849, USA
    Vet Ther 5:212-7. 2004
    ..and permethrin 7 days before exposure to Ixodes scapularis ticks that were naturally infected with Anaplasma phagocytophilum. A second group of eight beagles was not treated and was also exposed to infected ticks...
  99. ncbi New genetic variants of Anaplasma phagocytophilum and Anaplasma bovis from Korean water deer (Hydropotes inermis argyropus)
    Jun Gu Kang
    Laboratory of Veterinary Internal Medicine, Research Institute and BK21 Program for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Vector Borne Zoonotic Dis 11:929-38. 2011
    ..Using 16S rRNA-based nested PCR, Anaplasma phagocytophilum and Anaplasma bovis were detected in 42 (63.6%) and 23 (34.8%) of 66 KWD spleens, respectively. The 42 A...
  100. ncbi Wild game as a reservoir of Anaplasma phagocytophilum in north-western Poland
    Małgorzata Adamska
    Department of Genetics, University of Szczecin, Piastow 40B, 71 065 Szczecin, Poland
    Wiad Parazytol 53:103-7. 2007
    The aim of the study was to determine the role of game animals as reservoirs of Anaplasma phagocytophilum, a bacteria species transmitted by Ixodes ricinus ticks, from north-western Poland (Zachodniopomorskie vovoidship)...
  101. pmc Anaplasma phagocytophilum dense-cored organisms mediate cellular adherence through recognition of human P-selectin glycoprotein ligand 1
    Matthew J Troese
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0678, USA
    Infect Immun 77:4018-27. 2009
    b>Anaplasma phagocytophilum is an obligate intracellular bacterium that infects granulocytes to cause human granulocytic anaplasmosis. The susceptibilities of human neutrophils and promyelocytic HL-60 cells to A...

Research Grants54

  1. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..to build on key accomplishments from the prior funding period: 1) isolation of non-human-infectious Anaplasma phagocytophilum (Ap) from Camp Ripley, MN, ticks;2) stable transformation of Ap and identification of genes required for ..
  2. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..provided by applicant): Ixodes scapularis ticks transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among other ..
  3. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum and Ehrlichia chaffeensis cause emerging potentially fatal infectious diseases human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME), respectively...
  4. Subverted host cell signaling by AnkA in Anaplasma phagocytophilum infection
    Jacob W IJdo; Fiscal Year: 2012
    b>Anaplasma phagocytophilum, is a human pathogen that infects neutrophils and causes Human Granulocytic Ehrlichiosis. In the Unites States it is the second most common tick-associated infection, only surpassed by Lyme disease...
  5. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2013
    ..The causative agent, Anaplasma phagocytophilum, is an obligate intracellular pathogen that resides in 2 different locations during its life cycle -- ..
  6. Development of Paratransgenic ticks for Disease Control
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..optimize the Himar1 transposase system that we have successfully applied to transformation of tick-borne Anaplasma phagocytophilum, for SFG rickettsiae. This will address the recently found bias of Tn5 for GC rich regions...
  7. Anaplasma regulation of host granulocyte function
    John Stephen Dumler; Fiscal Year: 2013
    ..by applicant): Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  8. Human pathogenic bacterium induces actin phosphorylation to selectively regulate
    Hameeda Sultana; Fiscal Year: 2012
    ..Using Ixodes scapularis ticks and Anaplasma phagocytophilum (the agent of human granulocytic anaplasmosis) as an infection model, I provide evidence for the first ..
  9. Characterization of an Anaplasma phagocytophilum protein interfering with eukaryo
    Sukanya Narasimhan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum, the causative agent of human Anaplasmosis, is a tick-borne pathogen with an unusual tropism for the front-line immune defense cells (neutrophils)...
  10. Evolution of chronic infection in Anasplasma phagocytophilum
    Anthony F Barbet; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The tick-transmitted rickettsial pathogens Anaplasma phagocytophilum and A. marginale cause potentially fatal, acute or chronic disease of man and animals...
  11. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is a tick-borne obligate intracellular bacterial pathogen and the agent of granulocytic anaplasmosis in humans and animals. A...
  12. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is a tick-borne obligate intracellular bacterial pathogen and the agent of granulocytic anaplasmosis in humans and animals. A...
  13. Vector and Host Contributions to the Regulation of E. chaffeensis Gene Expression
    Roman R Ganta; Fiscal Year: 2012
    ..ewingii and Anaplasma phagocytophilum, respectively...
  14. Keys to prevent cholesterol robbery and infection by intracellular bacteria
    Yasuko Rikihisa; Fiscal Year: 2013
    ..This disease is caused by infection with the obligatory intracellular bacterium, Anaplasma phagocytophilum. Given the propensity of A...
  15. Anaplasma phagocytophilum induce Ixodes scapularis antifreeze glycoprotein gene e
    Girish Neelakanta; Fiscal Year: 2012
    ..parts of United States, and transmit various human pathogens that include human anaplasmosis agent Anaplasma phagocytophilum. My preliminary data show that the presence of A. phagocytophilum in ticks increases the ability of I...
  16. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is an obligate intracellular bacterium and rickettsial pathogen that invades neutrophils and endothelial cells to cause the emerging and potentially fatal infection, human ..
  17. CRITICAL ROLE OF THE ASC/CASPASE-1 PATHWAY IN TICK-BORNE RICKETTSIOSES
    JOAO PEDRA; Fiscal Year: 2009
    ..The research will focus on the mechanisms of immunity against Anaplasma phagocytophilum and Rickettsia conorii, two pathogens from the tick-borne rickettsial group...
  18. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum is an obligate intracellular bacterial pathogen that invades neutrophils and endothelial cells to cause the emerging and potentially fatal infection, human granulocytic ..
  19. Ehrlichiacidal Mechanism in Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2011
    ..This disease is caused by Anaplasma phagocytophilum, a Gram-negative obligatory intracellular bacterium. A...
  20. Rickettsial Immunity During Tick Transmission
    JOAO PEDRA; Fiscal Year: 2013
    ..protein - modulates inflammasome activation and facilitates transmission of the rickettsial pathogen Anaplasma phagocytophilum to a mammalian host...
  21. A. phagocytophilum and NF-kB signaling
    John Stephen Dumler; Fiscal Year: 2010
    Human granulocytic anaplasmosis (HGA) is tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  22. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
    ..ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum. Maps of these and other emerging pathogens can play an important role in the assessment of regional ..
  23. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..A similar gene conversion mechanism is used by Anaplasma phagocytophilum to express a large repertoire of outer membrane proteins in human patients and studies by others support ..
  24. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    DENISE STEINLEIN; Fiscal Year: 2005
    ..examines the infection and coinfection prevalence of Bartonella species, Borrelia burgdorferi, and Anaplasma phagocytophilum, in field-captured rodents and ectoparasites in northern California...
  25. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    ..This information will provide the framework for rational design of new therapies aimed at modulating immune mechanisms and design of preventative measures aimed at immunization. ..
  26. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ABSTRACT Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils...
  27. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..chaffeensis virulence determinants and their pathogenic mechanisms. The results may point to potential chemotherapy, chemopreventive and/or vaccine candidates for treatment and prevention of human ehrlichiosis. ..
  28. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  29. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  30. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    Ehrlichia chaffeensis and Anaplasma phagocytophilum cause emerging infectious diseases, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), respectively...
  31. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    Ulrike Munderloh; Fiscal Year: 2001
    ....
  32. Granulocytic Ehrlichiosis: Cell-Pathogen Interactions
    Dori Borjesson; Fiscal Year: 2005
    ..Currently, the candidate is a junior faculty member at a strong research institution with a clear mandate and desire to pursue an independent research program. ..
  33. Identification of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2006
    ..HGA is caused by Anaplasma phagocytophilum, an obligate intracellular bacterium that colonizes a most unusual host cell - the neutrophil...
  34. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2008
    ..g., Anaplasma phagocytophilum [Ap]) infect humans and their clinical correlates; and to complete the molecular and modeling components ..
  36. Tyrosine phosphorylation during A. phagocytophilum invasion
    Jacob Ijdo; Fiscal Year: 2008
    ..These pathogens alter cellular processes by introducing bacterial factors into the host cell. Anaplasma phagocytophilum, which[unreadable] causes Human Granulocytic Ehrlichiosis, is a unique intracellular organism because it ..
  37. Identifying human genes required by tick-borne pathogens
    Ulrike Munderloh; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The biology of Anaplasma phagocytophilum (Ap) and its host are intertwined...
  38. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  39. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2002
    ..chaffeensis and other closely related organisms. ..
  40. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..The sponsor has an active research program in vector borne disease has successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  41. Tissue Specific Borrelia Gene Expession
    Erol Fikrig; Fiscal Year: 2005
    ....
  42. Immunopathogenesis of Human Granulocytic Anaplasmosis
    Erol Fikrig; Fiscal Year: 2008
    ..The causative agent, Anaplasma phagocytophilum, is an obligate intracellular pathogen that resides in 2 different locations during its life cycle -- ..
  43. Neutrophil gene expression induced by A. phagocytophila
    Erol Fikrig; Fiscal Year: 2004
    ..phagocytophila uses to interfere with neutrophil differentiation and function ..
  44. Blood-brain barrier traversal by African trypanosomes
    DENNIS GRAB; Fiscal Year: 2005
    ..Armed with this knowledge we will be better able to design therapies that will stop the parasites from entering the brain and prevent many of the agonizing neurological symptoms, which eventually lead to death. ..
  45. Anaplasma - B. burgorferi/endothelijm interactions
    DENNIS GRAB; Fiscal Year: 2006
    ..Human granulocytic anaplasmosis (HGA) is caused by Anaplasma phagocytophilum, a rickettsia of neutrophils that is also transmitted by the deer tick, Ixodes scapularis...
  46. American Society for Rickettsiology conference
    ROMAN GANTA; Fiscal Year: 2005
    ..abstract_text> ..
  47. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2006
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about important bacterial defenses mounted in response to this hostile environment. ..
  48. Regulating I. scapularis and the Role of Entomopathogenic Fungi
    Thomas Daniels; Fiscal Year: 2008
    ..scapularis in lab studies. Long- term health benefits might also accrue with the reduction in pesticide use those results from the availability of an effective biocontrol agent. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. American Society for Rickettsiology Conference 2006
    ROMAN GANTA; Fiscal Year: 2006
    ..abstract_text> ..
  50. Toll-like receptor responses to West Nile virus
    Erol Fikrig; Fiscal Year: 2007
    ..These studies should increase our understanding of the role of TLR3 in viral recognition, and may lead to new strategies to prevent, or treat, WN virus infection. [unreadable] [unreadable]..
  51. Regulation of gp91phox by Anaplasma phagocytophila
    Venetta Thomas; Fiscal Year: 2007
    ..Aim 2. To define the effect of A. phagocytophila infection on the activity of the activator proteins and their binding capacity of the gp91phox promoter. ..
  52. Symposium on the Landscape Ecology of Infectious Disease
    MICHAEL WIMBERLY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2007
    ..In addition, these studies will lead to a more thorough understanding of neutrophil biology, specifically he factors that regulate rac2 mRNA expression and NADPH oxidase activation. ..