staphylococcus epidermidis

Summary

Summary: A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.

Top Publications

  1. ncbi Pathogenesis of infections due to coagulase-negative staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Lancet Infect Dis 2:677-85. 2002
  2. pmc Staphylococcal biofilm disassembly
    Blaise R Boles
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, MI 48109, USA
    Trends Microbiol 19:449-55. 2011
  3. ncbi Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis
    Zhiqiang Qin
    Key Laboratory of Medical Molecular Virology of Ministry of Education and Public Health, Institutes of Biomedical Sciences and Medical Microbiology, Shanghai Medical School of Fudan University Box 228, Yi Xue Yuan Road 138, Shanghai 200032, P R China
    Microbiology 153:2083-92. 2007
  4. pmc Staphylococcus epidermidis--the 'accidental' pathogen
    Michael Otto
    National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 9000 Rockville Pike Building 33 1W10, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 7:555-67. 2009
  5. pmc Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 121:238-48. 2011
  6. ncbi Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization
    Tadayuki Iwase
    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105 8461 Japan
    Nature 465:346-9. 2010
  7. pmc Differential roles of poly-N-acetylglucosamine surface polysaccharide and extracellular DNA in Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Era A Izano
    Medical Science Building, Room C 636, 185 S Orange Ave, Newark, NJ 07103, USA
    Appl Environ Microbiol 74:470-6. 2008
  8. pmc Molecular basis of Staphylococcus epidermidis infections
    Michael Otto
    Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Semin Immunopathol 34:201-14. 2012
  9. ncbi Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis
    C Heilmann
    Universitat Tubingen, Germany
    Mol Microbiol 20:1083-91. 1996
  10. ncbi A novel staphylococcal internalization mechanism involves the major autolysin Atl and heat shock cognate protein Hsc70 as host cell receptor
    Nina Hirschhausen
    Institute of Medical Microbiology, Department of Infectiology, University Hospital of Munster, Munster, Germany
    Cell Microbiol 12:1746-64. 2010

Detail Information

Publications300 found, 100 shown here

  1. ncbi Pathogenesis of infections due to coagulase-negative staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Lancet Infect Dis 2:677-85. 2002
    ..the pathogenesis of infections due to CoNS and particularly focuses on virulence factors of the species Staphylococcus epidermidis. S epidermidis has been identified as a major cause of nosocomial infections, especially in patients ..
  2. pmc Staphylococcal biofilm disassembly
    Blaise R Boles
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, MI 48109, USA
    Trends Microbiol 19:449-55. 2011
    Staphylococcus aureus and Staphylococcus epidermidis are a frequent cause of biofilm-associated infections that are a tremendous burden on our healthcare system...
  3. ncbi Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis
    Zhiqiang Qin
    Key Laboratory of Medical Molecular Virology of Ministry of Education and Public Health, Institutes of Biomedical Sciences and Medical Microbiology, Shanghai Medical School of Fudan University Box 228, Yi Xue Yuan Road 138, Shanghai 200032, P R China
    Microbiology 153:2083-92. 2007
    b>Staphylococcus epidermidis has become a serious nosocomial pathogen frequently causing infections associated with implanted foreign materials. Biofilm formation is considered a major factor determining S...
  4. pmc Staphylococcus epidermidis--the 'accidental' pathogen
    Michael Otto
    National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 9000 Rockville Pike Building 33 1W10, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 7:555-67. 2009
    Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host...
  5. pmc Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 121:238-48. 2011
    ..involving biofilms frequently develop on indwelling medical devices in hospitalized patients, and Staphylococcus epidermidis is the leading cause of infection in this setting...
  6. ncbi Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization
    Tadayuki Iwase
    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105 8461 Japan
    Nature 465:346-9. 2010
    ..Here we show that the serine protease Esp secreted by a subset of Staphylococcus epidermidis, a commensal bacterium, inhibits biofilm formation and nasal colonization by Staphylococcus aureus, a ..
  7. pmc Differential roles of poly-N-acetylglucosamine surface polysaccharide and extracellular DNA in Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Era A Izano
    Medical Science Building, Room C 636, 185 S Orange Ave, Newark, NJ 07103, USA
    Appl Environ Microbiol 74:470-6. 2008
    Staphylococcus aureus and Staphylococcus epidermidis are major human pathogens of increasing importance due to the dissemination of antibiotic-resistant strains...
  8. pmc Molecular basis of Staphylococcus epidermidis infections
    Michael Otto
    Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Semin Immunopathol 34:201-14. 2012
    b>Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin...
  9. ncbi Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis
    C Heilmann
    Universitat Tubingen, Germany
    Mol Microbiol 20:1083-91. 1996
    The Staphylococcus epidermidis genes icaABC are involved in the synthesis of the polysaccharide intercellular adhesin (PIA), which is located mainly on the cell surface, as shown by immunofluorescence studies with PIA-specific antiserum...
  10. ncbi A novel staphylococcal internalization mechanism involves the major autolysin Atl and heat shock cognate protein Hsc70 as host cell receptor
    Nina Hirschhausen
    Institute of Medical Microbiology, Department of Infectiology, University Hospital of Munster, Munster, Germany
    Cell Microbiol 12:1746-64. 2010
    Staphylococcus aureus and Staphylococcus epidermidis can cause serious chronic and recurrent infections that are difficult to eradicate. An important pathogenicity factor in these infections caused by S...
  11. ncbi Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface
    C Heilmann
    Institut fur Medizinische Mikrobiologie, Munster, Germany
    Mol Microbiol 24:1013-24. 1997
    ..multilayered cell clusters (intercellular adhesion) is proposed to be the major pathogenicity factor in Staphylococcus epidermidis foreign-body-associated infections...
  12. ncbi Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles
    Danielle Da Silva Trentin
    Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    J Ethnopharmacol 137:327-35. 2011
    ..The aim of this study was to investigate the antibiofilm and antibacterial activities of 45 aqueous extracts from 24 Caatinga plant species...
  13. ncbi A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence
    Cuong Vuong
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:54881-6. 2004
    ..b>Staphylococcus epidermidis is an important human pathogen that frequently causes persistent infections by biofilm formation on ..
  14. ncbi Staphylococcus epidermidis infections
    Cuong Vuong
    Rocky Mountain Laboratories, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 903 S 4th Street, Hamilton, MT 59840, USA
    Microbes Infect 4:481-9. 2002
    The opportunistic human pathogen Staphylococcus epidermidis has become the most important cause of nosocomial infections in recent years. Its pathogenicity is mainly due to the ability to form biofilms on indwelling medical devices...
  15. pmc Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections
    Yuping Lai
    Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California 92161, USA
    J Invest Dermatol 130:2211-21. 2010
    ..In this study we evaluated whether the commensal microorganism Staphylococcus epidermidis may enhance production of antimicrobial peptides by keratinocytes and thus augment skin defense against ..
  16. pmc Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections
    C R Arciola
    Research Laboratory on Biocompatibility of Implant Materials, Rizzoli Orthopedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Clin Microbiol 39:2151-6. 2001
    Both Staphylococcus epidermidis and Staphylococcus aureus are important causes of infections associated with catheters and other medical devices. It has recently been shown that not only S. epidermidis but also S...
  17. pmc Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin
    Anna L Cogen
    Division of Dermatology, Department of Medicine, University of California San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 130:192-200. 2010
    ..In this study, we hypothesized that peptides produced by a normal microbial resident of human skin, Staphylococcus epidermidis, might also act as an antimicrobial shield and contribute to normal defense at the epidermal interface...
  18. ncbi The giant extracellular matrix-binding protein of Staphylococcus epidermidis mediates biofilm accumulation and attachment to fibronectin
    Martin Christner
    Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Mol Microbiol 75:187-207. 2010
    Virulence of nosocomial pathogen Staphylococcus epidermidis is essentially related to formation of adherent biofilms, assembled by bacterial attachment to an artificial surface and subsequent production of a matrix that mediates ..
  19. pmc Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state
    Nuno Cerca
    Centro de Engenharia Biólogica, Universidade do Minho, Braga, Portugal
    Infect Immun 74:4849-55. 2006
    b>Staphylococcus epidermidis is an important cause of nosocomial infections. Virulence is attributable to elaboration of biofilms on medical surfaces that protect the organisms from immune system clearance...
  20. pmc Staphylococcus epidermidis strategies to avoid killing by human neutrophils
    Gordon Y C Cheung
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001133. 2010
    b>Staphylococcus epidermidis is a leading nosocomial pathogen. In contrast to its more aggressive relative S. aureus, it causes chronic rather than acute infections. In highly virulent S...
  21. ncbi Immune evasion by staphylococci
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Nat Rev Microbiol 3:948-58. 2005
    ..In contrast, Staphylococcus epidermidis must rely primarily on cell-surface polymers and the ability to form a biolfilm to survive in the host.
  22. ncbi Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2
    Gabriel Colon
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907 2022, USA
    J Biomed Mater Res A 78:595-604. 2006
    ..These bacteria (namely, Staphylococcus epidermidis) irreversibly adhere to an implant surface while various physiological stresses induce alterations in ..
  23. pmc Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis
    Yu Ming Chang
    Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan
    Proc Natl Acad Sci U S A 107:8617-22. 2010
    ..and their presence prevents the poly-N-acetylglucosamine production and biofilm formation in Staphylococcus epidermidis. Although TcaR was shown to interact with the ica promoter, the precise binding region and the mechanism ..
  24. ncbi Structure, function and contribution of polysaccharide intercellular adhesin (PIA) to Staphylococcus epidermidis biofilm formation and pathogenesis of biomaterial-associated infections
    Holger Rohde
    Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Eur J Cell Biol 89:103-11. 2010
    b>Staphylococcus epidermidis is of major importance in infections associated with indwelling medical devices. The tight pathogenic association is essentially linked to the species ability to form adherent biofilms on artificial surfaces...
  25. ncbi Human cathelicidin peptide LL37 inhibits both attachment capability and biofilm formation of Staphylococcus epidermidis
    E Hell
    Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Lett Appl Microbiol 50:211-5. 2010
    The aim of this work was to investigate the possible effect of human cathelicidin antimicrobial peptide LL37 on biofilm formation of Staphylococcus epidermidis, a major causative agent of indwelling device-related infections.
  26. ncbi ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus
    James P O'Gara
    School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Belfield, Dublin, Ireland
    FEMS Microbiol Lett 270:179-88. 2007
    ..now emerging for the existence of ica-independent biofilm mechanisms in both Staphylococcus aureus and Staphylococcus epidermidis. Teichoic acids, which are a major carbohydrate component of the S...
  27. ncbi Induction of Staphylococcus epidermidis biofilm formation via proteolytic processing of the accumulation-associated protein by staphylococcal and host proteases
    Holger Rohde
    Institut für Infektionsmedizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Mol Microbiol 55:1883-95. 2005
    Because of its biofilm forming potential Staphylococcus epidermidis has evolved as a leading cause of device-related infections. The polysaccharide intercellular adhesin (PIA) is significantly involved in biofilm accumulation...
  28. ncbi Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes
    Ketul C Popat
    Department of Physiology, Division of Bioengineering, University of California, 1700 4th Street, Box 2520, San Francisco, CA 94143 2520, USA
    Biomaterials 28:4880-8. 2007
    ..Also, there is enhanced osteoblast differentiation on nanotubes filled with gentamicin...
  29. ncbi Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways
    Ines Wanke
    Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Invest Dermatol 131:382-90. 2011
    ..These data indicate that commensal and pathogenic microorganisms evolved specific mechanisms to modulate innate immunity of the skin...
  30. pmc Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry
    Nuno Cerca
    Centro de Engenharia Biólogica, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Antimicrob Chemother 56:331-6. 2005
    To quantitatively compare the antibiotic susceptibility of biofilms formed by the coagulase-negative staphylococci (CoNS) Staphylococcus epidermidis and Staphylococcus haemolyticus with the susceptibility of planktonic cultures.
  31. pmc An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization
    C Mehlin
    Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    J Exp Med 189:907-18. 1999
    b>Staphylococcus epidermidis releases factors that activate the HIV-1 long terminal repeat, induce cytokine release, and activate nuclear factor B in cells of macrophage lineage...
  32. ncbi The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant staphylococcus
    Honglue Tan
    Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People s Hospital, Shanghai Jiao Tong University, School of Medicine, China
    Biomaterials 33:365-77. 2012
    ..Two clinical isolates, Staphylococcus epidermidis 389 and methicillin-resistant S. epidermidis (MRSE287), and two standard strains, S...
  33. ncbi High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms
    Kristina Flemming
    Department of Paediatrics, University Hospital of North Norway, Tromsø, Norway
    J Antimicrob Chemother 63:136-45. 2009
    ..The aim of the study was to investigate the antimicrobial effect of different antibiotics and synthetic antimicrobial peptidomimetics (SAMPs) on staphylococcal biofilms...
  34. pmc An Enterotoxin-Bearing Pathogenicity Island in Staphylococcus epidermidis
    Jyoti Madhusoodanan
    Department of Oral Biology, NYS Center of Excellence in Bioinformatics and Life Sciences, The State University of New York, NY, USA
    J Bacteriol 193:1854-62. 2011
    ..coagulase-negative staphylococci, no associated pathogenicity islands have been found in the genome of Staphylococcus epidermidis, a generally less virulent relative of S. aureus. We show here the first evidence of a composite S...
  35. pmc Role of surface protein SasG in biofilm formation by Staphylococcus aureus
    Joan A Geoghegan
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Bacteriol 192:5663-73. 2010
    ..Extensively purified recombinant B domain protein is very labile, and we propose that cleavage occurs spontaneously at labile peptide bonds and that this is necessary for biofilm formation...
  36. ncbi Foreign body infections due to Staphylococcus epidermidis
    Ilker Uckay
    University of Geneva Hospitals and Faculty of Medicine, Switzerland
    Ann Med 41:109-19. 2009
    ..a significant reduction of the threshold at which contaminating Gram-positive bacteria, particularly Staphylococcus epidermidis, become infectious and develop a biofilm with phenotypic resistance to almost all antibiotics...
  37. pmc Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain
    Steven R Gill
    Microbial Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    J Bacteriol 187:2426-38. 2005
    ..b>Staphylococcus epidermidis has emerged as a causative agent of infections often associated with implanted medical devices...
  38. ncbi Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections
    Holger Rohde
    Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Biomaterials 28:1711-20. 2007
    ..of polysaccharide intercellular adhesin (PIA) in clonally independent Staphylococcus aureus and Staphylococcus epidermidis strains isolated from prosthetic joint infections after total hip or total knee arthroplasty...
  39. ncbi Success through diversity - how Staphylococcus epidermidis establishes as a nosocomial pathogen
    Sonja M K Schoenfelder
    Queen s University Belfast, Centre for Infection and Immunity, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    Int J Med Microbiol 300:380-6. 2010
    b>Staphylococcus epidermidis normally is a commensal inhabitant of the healthy human skin and mucosa, but also a common nosocomial pathogen in immunocompromised patients. Living at the edge between commensalism and pathogenicity, S...
  40. ncbi Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development
    Linda M Holland
    School of Biomolecular and Biomedical Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Microbiology 157:408-18. 2011
    ..polysaccharide intercellular adhesin (PIA) and wall teichoic acids (WTA) are structural components of Staphylococcus epidermidis biofilms...
  41. pmc Staphylococcus epidermidis uses distinct mechanisms of biofilm formation to interfere with phagocytosis and activation of mouse macrophage-like cells 774A.1
    Nina N Schommer
    Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Zentrum für Diagnostik, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Infect Immun 79:2267-76. 2011
    Assembly of adherent biofilms is the key mechanism involved in Staphylococcus epidermidis virulence during device-associated infections...
  42. pmc Detection of virulence-associated genes not useful for discriminating between invasive and commensal Staphylococcus epidermidis strains from a bone marrow transplant unit
    Holger Rohde
    Institut für Infektionsmedizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Clin Microbiol 42:5614-9. 2004
    Because of their biofilm-forming capacity, invasive Staphylococcus epidermidis isolates, which cause the majority of nosocomial catheter-related bloodstream infections (BSIs), are thought to be selected at the time of catheter insertion ..
  43. pmc Extracellular carbohydrate-containing polymers of a model biofilm-producing strain, Staphylococcus epidermidis RP62A
    Irina Sadovskaya
    Laboratoire de Recherche sur les Biomatériaux et les Biotechnologies, Universite du Littoral Cote d Opale, Quai Masset, Bassin Napoleon, BP 120, 62327 Boulogne sur mer Cedex, France
    Infect Immun 73:3007-17. 2005
    Staphylococcus aureus and coagulase-negative staphylococci, primarily Staphylococcus epidermidis, are recognized as a major cause of nosocomial infections associated with the use of implanted medical devices...
  44. pmc Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing
    Robin K Pettit
    Cancer Research Institute, Arizona State University, Tempe, Arizona 85287 2404, USA
    Antimicrob Agents Chemother 49:2612-7. 2005
    ..b>Staphylococcus epidermidis ATCC 35984 biofilms treated with eight different approved antibiotics and five different experimental ..
  45. ncbi Characterization of the N-acetylglucosaminyltransferase activity involved in the biosynthesis of the Staphylococcus epidermidis polysaccharide intercellular adhesin
    C Gerke
    Mikrobielle Genetik, Universitat Tubingen, Waldhäuser Strasse 70 8, 72076 Tubingen, Germany
    J Biol Chem 273:18586-93. 1998
    ..intercellular adhesin (PIA) is an important factor in the colonization of medical devices by Staphylococcus epidermidis. The genes encoding PIA production are organized in the icaADBC (intercellular adhesion) operon...
  46. ncbi Lysostaphin as a potential therapeutic agent for staphylococcal biofilm eradication
    Elzbieta Walencka
    Department of Immunology and Infectious Biology, Institute of Microbiology and Immunology, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Pol J Microbiol 54:191-200. 2005
    ..Also BICOXA for S. epidermidis RP12 and A4c strains, but not for 6756/99 MRSE biofilms was reduced when lysostaphin was simultaneously used...
  47. ncbi Detection of icaA and icaD loci by polymerase chain reaction and biofilm formation by Staphylococcus epidermidis isolated from dialysate and needles in a dialysis unit
    K Chaieb
    Laboratoire de Bactériologie de l Hôpital Ibn El Jazzar, rue Ibn Eljazzr, Kairouan 3140, Tunisia
    J Hosp Infect 61:225-30. 2005
    b>Staphylococcus epidermidis, a coagulase-negative staphylococcus, is a major cause of infections associated with indwelling medical devices...
  48. ncbi Phagocytosis of staphylococci biofilms by polymorphonuclear neutrophils: S. aureus and S. epidermidis differ with regard to their susceptibility towards the host defense
    Frank Guenther
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Int J Artif Organs 32:565-73. 2009
    ....
  49. pmc CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis
    Marat R Sadykov
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, NE, USA
    Microbiology 157:3458-68. 2011
    b>Staphylococcus epidermidis is an opportunistic bacterium whose infections often involve the formation of a biofilm on implanted biomaterials. In S...
  50. ncbi Scenery of Staphylococcus implant infections in orthopedics
    Lucio Montanaro
    Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Future Microbiol 6:1329-49. 2011
    ..Staphylococcus aureus and Staphylococcus epidermidis are the leading etiologic agents of orthopedic implant infection...
  51. pmc SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development
    Maria Angeles Tormo
    Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera CEU, Carretera Náquera Moncada, Km 4, 5 46113 Moncada, Valencia, Spain
    J Bacteriol 187:2348-56. 2005
    b>Staphylococcus epidermidis biofilm formation is associated with the production of the polysaccharide intercellular adhesin (PIA)--poly-N-acetylglucosamine polysaccharide (PNAG) by the products of the icaADBC operon...
  52. ncbi Prevalence of the ica operon and insertion sequence IS256 among Staphylococcus epidermidis prosthetic joint infection isolates
    A Koskela
    Clinical Research Center, Orebro University Hospital, 701 85, Orebro, Sweden
    Eur J Clin Microbiol Infect Dis 28:655-60. 2009
    ..b>Staphylococcus epidermidis is the most important pathogen involved in foreign-body infections. S...
  53. ncbi Differential innate immune responses of a living skin equivalent model colonized by Staphylococcus epidermidis or Staphylococcus aureus
    Diana B Holland
    Skin Research Centre, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    FEMS Microbiol Lett 290:149-55. 2009
    b>Staphylococcus epidermidis is a commensal on skin, whereas Staphylococcus aureus is a transient pathogen. The aim was to determine whether the skin's innate defence systems responded differently to these microorganisms...
  54. pmc Augmented expression of polysaccharide intercellular adhesin in a defined Staphylococcus epidermidis mutant with the small-colony-variant phenotype
    Nahed Al Laham
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstr 10, 48149 Munster, Germany
    J Bacteriol 189:4494-501. 2007
    ..a stable mutant in electron transport by interrupting one of the hemin biosynthetic genes, hemB, in Staphylococcus epidermidis. In fact, this mutant displayed a stable SCV phenotype with tiny colonies showing strong adhesion to the ..
  55. ncbi Studies on the enhanced production of extracellular lipase by Staphylococcus epidermidis
    Babu Joseph
    Department of Microbiology and Microbial Technology, College of Biotechnology and Allied Sciences, Allahabad Agricultural Institute Deemed University, Allahabad, India
    J Gen Appl Microbiol 52:315-20. 2006
    b>Staphylococcus epidermidis isolated from spoiled frozen marine fish samples exhibited optimum lipase activity of 8.1 U within 72 h in batch fermentation...
  56. ncbi Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition
    P Chaignon
    Laboratoire de Recherche sur les Biomatériaux et les Biotechnologies, Universite du Littoral Cote d Opale, Bassin Napoleon, BP 120, 62327, Boulogne sur Mer Cedex, France
    Appl Microbiol Biotechnol 75:125-32. 2007
    Bacterial infections are serious complications after orthopaedic implant surgery. Staphylococci, with Staphylococcus epidermidis as a leading species, are the prevalent and most important species involved in orthopaedic implant-related ..
  57. ncbi Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Rachna Singh
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Antimicrob Chemother 65:1955-8. 2010
    This study was carried out to elucidate the role of reduced antibiotic penetration in the resistance of Staphylococcus aureus and Staphylococcus epidermidis biofilms to different antibiotics.
  58. ncbi 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo
    Vincent Dioszeghy
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:6514-24. 2008
    ..in the regulation of cytokine/growth factor production both basally and after stimulation with Staphylococcus epidermidis cell-free supernatant...
  59. pmc Enzymatic detachment of Staphylococcus epidermidis biofilms
    Jeffrey B Kaplan
    Medical Science Building, Room C 636, 185 S Orange Avenue, Newark NJ 07103, USA
    Antimicrob Agents Chemother 48:2633-6. 2004
    The gram-positive bacterium Staphylococcus epidermidis is the most common cause of infections associated with catheters and other indwelling medical devices. S...
  60. pmc Lysostaphin disrupts Staphylococcus aureus and Staphylococcus epidermidis biofilms on artificial surfaces
    Julie A Wu
    Biosynexus Incorporated, Gaithersburg, Maryland 20877, USA
    Antimicrob Agents Chemother 47:3407-14. 2003
    ..001 to 0.064 microg/ml) and is also effective against Staphylococcus epidermidis at higher concentrations (MIC(90), 12.5 to 64 microg/ml)...
  61. pmc Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus
    Anna L Cogen
    Division of Dermatology, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 5:e8557. 2010
    ..Recently, phenol-soluble modulins (PSMs) from Staphylococcus epidermidis (S...
  62. pmc Current concepts in biofilm formation of Staphylococcus epidermidis
    Paul D Fey
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198 5900, USA
    Future Microbiol 5:917-33. 2010
    b>Staphylococcus epidermidis is a highly significant nosocomial pathogen mediating infections primarily associated with indwelling biomaterials (e.g., catheters and prostheses)...
  63. ncbi Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms
    Yufeng Yao
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 191:289-98. 2005
    ..To gain insight into the pathophysiology of the leading nosocomial pathogen, Staphylococcus epidermidis, we analyzed the genome of biofilm-forming S...
  64. ncbi Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis
    Zhiqiang Qin
    Division of Infectious Diseases, Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    Microbiology 155:2148-56. 2009
    ..pathogen, Pseudomonas aeruginosa, uses extracellular products to interact with the nosocomial pathogen Staphylococcus epidermidis. S. epidermidis biofilms and planktonic cultures were challenged with P...
  65. pmc Diversity of staphylococcal cassette chromosome mec structures in methicillin-resistant Staphylococcus epidermidis and Staphylococcus haemolyticus strains among outpatients from four countries
    Etienne Ruppe
    Laboratoire Associé CNR Résistance Dans les Flores Commensales, Hopital Bichat Claude Bernard, Paris, France
    Antimicrob Agents Chemother 53:442-9. 2009
    ..Ninety-six MR-CoNS strains, comprising 75 (78%) Staphylococcus epidermidis strains, 19 (20%) Staphylococcus haemolyticus strains, 1 (1%) Staphylococcus hominis strain, and 1 (1%) ..
  66. pmc Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat model
    M E Rupp
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Infect Immun 67:2656-9. 1999
    Biofilm production is thought to be a crucial factor in the ability of Staphylococcus epidermidis to produce a biomaterial-based infection...
  67. ncbi A microtiter-plate screening method for biofilm disinfection and removal
    Betsey Pitts
    Center for Biofilm Engineering, Montana State University, Bozeman, MT 59717, USA
    J Microbiol Methods 54:269-76. 2003
    ..Biofilms of Pseudomonas aeruginosa or Staphylococcus epidermidis were grown in 96-well plates, treated with an agent, then stained with either the biomass indicator ..
  68. pmc Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses
    Jakob Begun
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Pathog 3:e57. 2007
    b>Staphylococcus epidermidis and Staphylococcus aureus are leading causes of hospital-acquired infections that have become increasingly difficult to treat due to the prevalence of antibiotic resistance in these organisms...
  69. ncbi Staphylococcus epidermidis biofilms: importance and implications
    J P O'Gara
    Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin
    J Med Microbiol 50:582-7. 2001
    The coagulase-negative staphylococci and, in particular, Staphylococcus epidermidis, have emerged as major nosocomial pathogens associated with infections of implanted medical devices...
  70. pmc The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection
    Valentin Antoci
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biomaterials 29:4684-90. 2008
    ..These findings indicate that antibiotic derivatization of implants can result in a surface that can resist bacterial colonization. This technology holds great promise for the prevention and treatment of periprosthetic infections...
  71. ncbi A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells
    Mizuho Natsuka
    Department of Microbiology and Immunology, Tohoku University School of Dentistry, Aoba ku, Sendai, Japan
    Innate Immun 14:298-308. 2008
    ..the pro-inflammatory cytokine-inducing abilities of PGNs and their fragments enzymatically prepared from Staphylococcus epidermidis ATCC 155: a polymer-type water-soluble PGN possessing an intact glycan chain (SEPS) and a monomer-type ..
  72. pmc Bacterial competition for human nasal cavity colonization: role of Staphylococcal agr alleles
    Gerard Lina
    Centre National de Référence des Staphylocoques, INSERM E 0230, IFR 62, Faculte de Medecine Laennec, Lyon, France
    Appl Environ Microbiol 69:18-23. 2003
    ....
  73. ncbi Quorum-sensing control of biofilm factors in Staphylococcus epidermidis
    Cuong Vuong
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 188:706-18. 2003
    b>Staphylococcus epidermidis is the most frequent cause of nosocomial sepsis and catheter-related infections, in which biofilm formation is considered to be the main virulence mechanism...
  74. pmc Bacterial adhesion: seen any good biofilms lately?
    W Michael Dunne
    Department of Pathology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Clin Microbiol Rev 15:155-66. 2002
    ..That this model does not reflect conditions found in nature might help explain the difficulties encountered in the management and treatment of biomedical implant infections...
  75. pmc Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate
    Juan E Velasquez
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Chem Biol 18:857-67. 2011
    ..The recently discovered lantibiotic epilancin 15X produced by Staphylococcus epidermidis 15X154 contains an unusual N-terminal lactate group...
  76. ncbi Mixed species biofilms of Candida albicans and Staphylococcus epidermidis
    Berit Adam
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    J Med Microbiol 51:344-9. 2002
    ..system was used to study the development in vitro of mixed species biofilms of Candida albicans and Staphylococcus epidermidis, two organisms commonly found in catheter-associated infections. Two strains of S...
  77. pmc Penetration of rifampin through Staphylococcus epidermidis biofilms
    Zhilan Zheng
    Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University Bozeman, Bozeman, Montana 59717 3980, USA
    Antimicrob Agents Chemother 46:900-3. 2002
    Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria...
  78. ncbi Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering
    Anne Catherine Raby
    Department of Medical Biochemistry and Immunology, Cardiff University, United Kingdom
    J Immunol 183:506-17. 2009
    ....
  79. ncbi Biofilm formation by Staphylococcus epidermidis on intraocular lens material
    Yukinobu Okajima
    First Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:2971-5. 2006
    To compare biofilm formation by Staphylococcus epidermidis on different intraocular lens (IOL) materials.
  80. pmc A critical concentration of neutrophils is required for effective bacterial killing in suspension
    Yongmei Li
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:8289-94. 2002
    We have examined the effect of neutrophil concentration on killing of a clinical isolate of Staphylococcus epidermidis. Human neutrophils at concentrations varying from 10(5) to 10(7) per ml were mixed in suspension with S...
  81. pmc Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis
    N Kobayashi
    Department of Hygiene, Sapporo Medical University School of Medicine, Japan
    Antimicrob Agents Chemother 42:717-20. 1998
    ..region was analyzed for clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE)...
  82. pmc Impact of the Staphylococcus epidermidis LytSR two-component regulatory system on murein hydrolase activity, pyruvate utilization and global transcriptional profile
    Tao Zhu
    Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College of Fudan University, Shanghai, PR China
    BMC Microbiol 10:287. 2010
    b>Staphylococcus epidermidis has emerged as one of the most important nosocomial pathogens, mainly because of its ability to colonize implanted biomaterials by forming a biofilm...
  83. ncbi Phenotypic and genotypic markers of Staphylococcus epidermidis virulence
    A Gelosia
    Department of Applied Biology and Biotechnology, RMIT University, 124 Latrobe Street, 3000 Melbourne, Victoria, Australia
    Clin Microbiol Infect 7:193-9. 2001
    OBJECTIVES: To analyze Staphylococcus epidermidis strains, previously tested for their virulence in a mouse model of subcutaneous infection, for various phenotypic traits (biofilm density, extracellular polysaccharide, slime-associated ..
  84. ncbi Isolation of methicillin-resistant coagulase-negative staphylococci from patients undergoing continuous ambulatory peritoneal dialysis (CAPD) and comparison of different molecular techniques for discriminating isolates of Staphylococcus epidermidis
    Elaine Marques de Mattos
    Laboratorio de Biologia Molecular de Bacterias, Instituto de Microbiologia Prof Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Diagn Microbiol Infect Dis 45:13-22. 2003
    ..primed polymerase chain reaction (AP-PCR) for characterizing isolates of methicillin-resistant Staphylococcus epidermidis (MRSE). Seventy-nine CNS isolates were recovered from the 11 CAPD patients studied...
  85. pmc TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia
    Tobias Strunk
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    PLoS ONE 5:e10111. 2010
    b>Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms...
  86. pmc Molecular characterization of methicillin-resistant Staphylococcus epidermidis clones: evidence of geographic dissemination
    Maria Miragaia
    Molecular Genetics Laboratory, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Clin Microbiol 40:430-8. 2002
    ..The large majority (87.4%) of the MRSE isolates studied were multiresistant...
  87. pmc Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus
    J H Heinrichs
    MedImmune, Inc, Gaithersburg, Maryland 20878, USA
    J Bacteriol 181:1436-43. 1999
    ..aureus culture medium. sir-encoded proteins may be involved in iron acquisition in vivo and therefore may be targets for antimicrobial agents...
  88. pmc The terminal A domain of the fibrillar accumulation-associated protein (Aap) of Staphylococcus epidermidis mediates adhesion to human corneocytes
    Robin L Macintosh
    Faculty of Life Sciences, D1401 Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Bacteriol 191:7007-16. 2009
    The opportunistic pathogen Staphylococcus epidermidis colonizes indwelling medical devices by biofilm formation but is primarily a skin resident. In many S...
  89. ncbi Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus
    Francois Barbier
    Bacteriology Unit and National Reference Center for Emergence of Resistance in Commensal Flora, 2EA 3964, Bichat Claude Bernard Hospital, Assistance Publique Hôpitaux de Paris and Xavier Bichat Medical School, Denis Diderot Paris 7 University, Paris, France
    J Infect Dis 202:270-81. 2010
    ..We assessed their potential role as a reservoir of staphylococcal cassette chromosome mec (SCCmec) IVa, the leading SCCmec subtype in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)...
  90. ncbi Differential effects of Pseudomonas aeruginosa on biofilm formation by different strains of Staphylococcus epidermidis
    Maria Pihl
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmo, Sweden
    FEMS Immunol Med Microbiol 59:439-46. 2010
    Pseudomonas aeruginosa and Staphylococcus epidermidis are common opportunistic pathogens associated with medical device-related biofilm infections...
  91. pmc Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis
    Nuno Cerca
    Centro de Engenharia Biólogica, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Res Microbiol 156:506-14. 2005
    b>Staphylococcus epidermidis is now well established as a major nosocomial pathogen associated with infections of indwelling medical devices...
  92. pmc Biofilm formation by Staphylococcus epidermidis depends on functional RsbU, an activator of the sigB operon: differential activation mechanisms due to ethanol and salt stress
    J K Knobloch
    Institut fur Medizinische Mikrobiologie und Immunologie, Universitatsklinikum Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Bacteriol 183:2624-33. 2001
    b>Staphylococcus epidermidis is a common pathogen in medical device-associated infections. Its major pathogenetic factor is the ability to form adherent biofilms...
  93. pmc Development of real-time in vivo imaging of device-related Staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to infection
    Cuong Vuong
    Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Infect Dis 198:258-61. 2008
    b>Staphylococcus epidermidis is the leading cause of hospital-acquired device-related infections, but there is a lack of suitable methods to investigate the pathogenesis of S. epidermidis infection. We created a bioluminescent strain of S...
  94. ncbi SdrF, a Staphylococcus epidermidis surface protein, binds type I collagen
    Carlos Arrecubieta
    Division of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:18767-76. 2007
    b>Staphylococcus epidermidis is the leading cause of device-related infections. These infections require an initial colonization step in which S. epidermidis adheres to the implanted material...
  95. ncbi Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis
    Miquel B Ekkelenkamp
    University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    FEBS Lett 579:1917-22. 2005
    ..elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry...
  96. pmc Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections
    Zhiqiang Qin
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology, Shanghai Medical School of Fudan University, Shanghai, PR China
    BMC Microbiol 6:96. 2006
    Coagulase-negative Staphylococcus epidermidis has become a major frequent cause of infections in relation to the use of implanted medical devices. The pathogenicity of S...
  97. pmc Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm
    Philip S Stewart
    Center for Biofilm Engineering, Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717 3980, USA
    Antimicrob Agents Chemother 53:3505-7. 2009
    Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water...
  98. pmc Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis
    Marat R Sadykov
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 190:7621-32. 2008
    b>Staphylococcus epidermidis is a major nosocomial pathogen primarily infecting immunocompromised individuals or those with implanted biomaterials (e.g., catheters)...
  99. pmc Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis
    Wen Yih Jeng
    Institute of Biological Chemistry, Taipei, Taiwan
    Nucleic Acids Res 36:1567-77. 2008
    Expression of the gene cluster icaADBC is necessary for biofilm production in Staphylococcus epidermidis. The ica operon is negatively controlled by the repressor IcaR...
  100. ncbi Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Antonia Nostro
    Dipartimento Farmaco Biologico, Facolta di Farmacia, Universita degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
    J Med Microbiol 56:519-23. 2007
    ..the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus (n=6) and S...
  101. ncbi Effect of berberine on Staphylococcus epidermidis biofilm formation
    Xiaoqing Wang
    Department of Orthopaedic Surgery, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    Int J Antimicrob Agents 34:60-6. 2009
    b>Staphylococcus epidermidis is one of the main causes of medical device-related infections owing to its adhesion and biofilm-forming abilities on biomaterial surfaces...

Research Grants63

  1. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..of 20 to 2000 <A substantially reduced established Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms, a phenomenon we termed the "electricidal effect" (Antimicrob Ag Chemother 2009;53:41)...
  2. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..to understand thresholds for effective biofilm prevention (Proteus mirabilis, Enterococcus faecalis, and Staphylococcus epidermidis);(2) to understand the light emission requirements at 590nm to photochemically prevent biofilm formation;..
  3. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..Although Staphylococcus aureus is by far the most virulent of species, Staphylococcus epidermidis and Staphylococcus lugdunensis have also been found to cause severe infections mostly in ..
  4. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..the growth of eight clinically important microorganisms, including Candida albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and ..
  5. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    ..aureus for the anterior nares niche have focused on individual species, e.g. Staphylococcus epidermidis, Streptococcus pneumoniae, Corynebacterium spp., isolated from culture...
  6. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2012
    ..b>Staphylococcus epidermidis and Klebsiella pneumoniae are common causes of intravascular catheter infection, in part due to their ..
  7. Studies of metal-dependent intercellular adhesion in Staphylococcal biofilms
    Andrew B Herr; Fiscal Year: 2013
    ..provided by applicant): Nearly two-thirds of all hospital-acquired infections (HAIs) are caused by Staphylococcus epidermidis and S. aureus...
  8. Characterization of a novel murine model of central nervous system catheter infec
    Jessica Snowden; Fiscal Year: 2013
    ..The most common organisms responsible for these central nervous system (CNS) catheter infections, Staphylococcus epidermidis and Staphylococcus aureus, are both known to form biofilms2,3...
  9. Reduction of Tunneled Dialysis Catheter Dysfunction Via Long Term Nitric Oxide Re
    Prabir Roy-Chaudhury; Fiscal Year: 2013
    ..prototype dual lumen catheters for effective biofilm prevention (Staphylococcus aureus, and Staphylococcus epidermidis);(2) to optimize the polymeric formulation to allow for 3 months of shelf life after proper ..
  10. Citric acid cycle regulation of exopolysaccharide synthesis in staphylococci
    GREG ALAN SOMERVILLE; Fiscal Year: 2013
    Staphylococcus aureus and Staphylococcus epidermidis are opportunistic bacterial pathogens responsible for a wide array of human and animal diseases. Importantly, S. aureus and S...
  11. Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniae
    David S Stephens; Fiscal Year: 2010
    ..had significant homology to the erythromycin resistance ATP-binding cassette (ABC) protein, MsrA, of Staphylococcus epidermidis. The 3'end of mega contains three convergently transcribed ORFs (ORF5, ORF4, ORF3), homologous to ..
  12. Antibiotic pressure and selection of TCA cycle mutants in Staphylococcus epidermi
    Paul D Fey; Fiscal Year: 2010
    ..Data presented in this application demonstrate that 26% of clinical Staphylococcus epidermidis isolates are TCA cycle defective. In addition, oxacillin time-kill studies against a S...
  13. Effects of Shear on Specific Adhesion Receptor Expression and Binding in the Bact
    James D Bryers; Fiscal Year: 2010
    ..With NIH support, we will develop this protocol using the model pure culture system of Staphylococcus epidermidis (SE) binding to immobilized fibronectin (FN). Our specific aims in this two-year project will be: 1...
  14. Mechanisms of CRISPR Interference
    Erik J Sontheimer; Fiscal Year: 2013
    ..We are using the gram-positive pathogen Staphylococcus epidermidis as a model system because of its clinical importance and experimental tractability...
  15. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    JAMES MORLEY ANDERSON; Fiscal Year: 2010
    ..how blood protein adsorption and shear stress mediate genotypic and phenotypic aspects of initial Staphylococcus epidermidis adhesion and biofilm formation, 2) examine the role of biomaterial surface chemistry of clinically ..
  16. Re-engineering the arylomycins for antibiotic activity
    Floyd E Romesberg; Fiscal Year: 2010
    ..we discovered that the mechanism of resistance in the important human pathogens Escherichia coli and Staphylococcus epidermidis is based on the introduction of a proline residue into a conserved region of the SPase substrate binding ..
  17. Skin Microbiome in epidermal immune defense
    Richard L Gallo; Fiscal Year: 2013
    ..data show for the first time that the most commonly cultured bacterium of the human skin microbiome, Staphylococcus epidermidis, can work in three ways to aid skin immune defense. 1. S...
  18. Skin Microbiome in epidermal immune defense
    Richard Gallo; Fiscal Year: 2009
    ..data show for the first time that the most commonly cultured bacterium of the human skin microbiome, Staphylococcus epidermidis, can work in three ways to aid skin immune defense. 1. S...
  19. Prevention of Bacterial Biofilms on CSF Shunts through the Incorporation of Novel
    Eva Garland; Fiscal Year: 2011
    ..to incorporate Agilyte" into silicone catheters. 2. To assess biofilm buildup of Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa on an Agilyte" + antibiotic impregnated (AAI) silicone catheter using an in ..
  20. Population Genomics of Staphylococci
    Ashley Robinson; Fiscal Year: 2013
    ..b>Staphylococcus epidermidis and other coagulase-negative staphylococci, once exclusively considered to be commensal species, have ..
  21. Anti-staphylococcal activities of A. actinomycetemcomitans dispersin B
    Jeffrey B Kaplan; Fiscal Year: 2010
    ..The extracellular matrix of Staphylococcus aureus and Staphylococcus epidermidis, the most common device-associated pathogens, contains a sticky polysaccharide named PNAG (poly-N-..
  22. Novel Chemical Analyses of the Biofilm-Biomaterial Interface
    Luke Hanley; Fiscal Year: 2010
    ..The studies will be performed on antibiotic spiked multilayer model films and Staphylococcus epidermidis biofilms. S...
  23. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..aureus, Staphylococcus epidermidis, or Pseudomonas aeruginosa biofilms exposed to antimicrobials in use in clinical practice and ..
  24. Novel antibacterials targeting the 50S ribosomal subunit
    Joyce Sutcliffe; Fiscal Year: 2005
    ..use in nosocomial infections caused by Gram-positive pathogens, a drug must cover Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Enterococcus faecium...
  25. Mechanisms of Sequence-Based Resistance to Viruses and Plasmids in Eubacteria
    Erik J Sontheimer; Fiscal Year: 2010
    ..database searches have revealed the presence of a relatively simple CRISPR/cas locus in a strain of Staphylococcus epidermidis, and the sequence of the locus suggests that it specifies resistance not only to bacteriophages but also ..
  26. Multi-componet Vaccine for Staphylcoccus epidermidis
    Tomas Maira Litran; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Coagulase-negative staphylococci (CoNS), notably Staphylococcus epidermidis, are a predominant cause of hospital-acquired infections and treatment can be difficult owing to biofilm formation and ..
  27. GENOME ANALYSIS OF STAPHYLOCOCCUS EPIDERMIDIS
    Steven Gill; Fiscal Year: 2001
    The goal of this project is to determine the complete genome sequence of Staphylococcus epidermidis, a coagulase negative staphylococci (CoNS) which is an emerging pathogen of increasing clinical significance. Of the CoNS group, S...
  28. CONTROL OF BACTERIAL TOXINS BY VIRUSES AND PLASMIDS
    Randall Holmes; Fiscal Year: 2004
    ..will determine the molecular basis for function of DtxR, IdeR and the homologous regulator SirR from Staphylococcus epidermidis. The investigators will use structure-based design to develop new antimicrobial drugs called "super-..
  29. ADHESINS OF COAGULASE NEGATIVE STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 1999
    ..applicant's abstract): This application's long- term specific aims are to elucidate mechanisms whereby Staphylococcus epidermidis and other coagulase-negative staphylococci (CoNS) have become one of the most important nosocomial ..
  30. FEEDING STRATEGIES FOR LOW BIRTH WEIGHT INFANTS
    RICHARD SCHANLER; Fiscal Year: 2000
    ..specific functional antibody titers in serial milk samples the incidence of pathogen--specific sepsis (Staphylococcus epidermidis, Staphylococcus aureus), and to determine if specific nursery protocols, such as skin-to--skin contact ..
  31. IRON-SIRR COREGULATION OF S.EPIDERMIDIS VIRULENCE
    Robert Harrison; Fiscal Year: 2001
    ..is an important co-regulator of virulence in many bacterial species including Staphylococcus aurues and Staphylococcus epidermidis both significant human pathogens...
  32. Biomaterials that Promote Healing & Prevent Infection
    JAMES BRYERS; Fiscal Year: 2004
    ..Objectives are: 1. We will isolate and characterize the cognate receptor(s) that the bacterium, Staphylococcus epidermidis (SE), employs to bind to fibronectin (FN)-coated surfaces - i.e...
  33. Prevention of Biofilm Growth on Orthopedic Implant Materials Through Chemical Sur
    ELLEN GAWALT; Fiscal Year: 2009
    ..Biofilm development will be tested by using a model bacterium, Staphylococcus epidermidis and methods that assess biofilm formation on surfaces including counting, imaging and kinetic analysis ..
  34. VIRULENCE AND IMMUNITY TO STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 2000
    ..has previously been determined to be the protective capsular polysaccharide/adhesin (PS/A) antigen of Staphylococcus epidermidis, raising the possibility that PNSG could be used as a "pan-staphylococcal" vaccine...
  35. FOREIGN BODY REACTION AND DEVICE CENTERED INFECTION
    Liping Tang; Fiscal Year: 2001
    ..bactericidal products, such as superoxide, and indirectly promoting the survival of implant-associated Staphylococcus epidermidis. However, it is still unclear how adsorbed fibrinogen actually enhances the persistence of implant-..
  36. FOREIGN BODY REACTION AND DEVICE CENTERED INFECTION
    Liping Tang; Fiscal Year: 2002
    ..bactericidal products, such as superoxide, and indirectly promoting the survival of implant-associated Staphylococcus epidermidis. However, it is still unclear how adsorbed fibrinogen actually enhances the persistence of implant-..
  37. Environmental Regulation of Staphylococcus epidermidis PIA Synthesis
    GREG SOMERVILLE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Staphylococcus epidermidis causes about 250,000 hospital-acquired infections per year in the U.S.A., making it the leading cause of nosocomial infections...
  38. IRON ACQUISITION BY STAPHYLOCOCCI
    Loreen Herwaldt; Fiscal Year: 1993
    ..Recently Staphylococcus epidermidis has become one of the most common causes of nosocomial bloodstream infections...
  39. Menaquinone biosynthesis: a drug target in Gram-positive bacteria
    Dean Crick; Fiscal Year: 2007
    ..these compounds are also active against organisms such as methicillin resistant Stapylococcus aureus and Staphylococcus epidermidis, and are expected to be effective against Bacillus anthracis and Listeria monocytogenes as well...
  40. Biofilm growth and detachment of an oral pathogen
    Jeffrey Kaplan; Fiscal Year: 2007
    ..abstract_text> ..
  41. Antibiotic Susceptibility of Bacteria in Biofilms
    Philip Stewart; Fiscal Year: 2005
    ..This project will afford a rich interdisciplinary training experience for the three participating graduate students. ..
  42. Toll-Like Receptors in Bacterial Antigen Induced HIV-LTR
    Ozlem Equils; Fiscal Year: 2004
    ..abstract_text> ..
  43. ica phase variation in Staphylococcus epidermidis
    PAUL FEY; Fiscal Year: 2005
    b>Staphylococcus epidermidis is the preeminent cause of infections involving biomaterial-based devices. The most important step in the pathogenesis of S...
  44. Salivary Amylase: Role in Dental Caries Pathogenesis
    Narayanan Ramasubbu; Fiscal Year: 2007
    ..Finally, we are excited that our approach in dissecting the contribution of amylase to foster the colonization of S. mutans may serve as a model to study the role of other salivary proteins in the oral cavity. ..
  45. PCR assays to detect individual pneumococcal serotypes
    LORRY RUBIN; Fiscal Year: 2006
    ..Furthermore, they will be critical for determining the effects of current and future pneumococcal vaccines on serotype-specific carriage. ..
  46. Role(s) of Microglia in Alzheimer's Disease
    Samuel Silverstein; Fiscal Year: 2004
    ..5. Determine the effects of fAbeta immunization of CD18 null -/Tg hAPP+/- and Fcgamma receptor null/Tg hAPP+/- mice on AD-like pathology...
  47. ARYL BRANCHED CHAIN ACYL COA ESTERS INHIBIT MYCOBACTERIU
    Samuel Silverstein; Fiscal Year: 2003
    ..tb growth, and to test the effects of GFZ and of its 3- and 6-propylene analogs, alone and in combination with other anti-tuberculosis drugs, on M.tb growth in macrophages and in mice. ..
  48. Novel Therapies for BioFilm-Related Infections
    Timothy Opperman; Fiscal Year: 2005
    ..epidermidis. The work in Phase I will provide all the molecular genetic tools and screening methods needed in Phase II for the discovery of potent small molecule inhibitors of staphylococcal biofilm formation. ..
  49. THE CLOUD ADULT
    Robert Sherertz; Fiscal Year: 2003
    ..aureus associated with a viral URI, have been shown to cause outbreaks. Understanding the "cloud phenomenon" may facilitate S.aureus outbreak prevention and possibly the transmission of other pathogens, as well. ..
  50. PROTEOGLYCANS WOUND REPAIR AND INFLAMMATION
    Richard Gallo; Fiscal Year: 2005
    ..The GAG ligand(s) responsible for activation will be sought and gene expression profiles investigated. Successful completion of these aims will reveal fundamental events in wound repair and may suggest new approaches to wound therapy. ..
  51. UNDERSTANDING THE PATHOGENESIS OF STAPHYLOCOCCUS AUREUS
    Vance Fowler; Fiscal Year: 2003
    ..Accomplishing the aims of this proposal will contribute to improved clinical management of patients with S. aureus bacteremia, and will add to the understanding of S. aureus virulence factors. ..
  52. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
  53. Novel Targets for Treatment of Pseudomonas aeruginosa
    Philip Lister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Epithelial Innate Immune Response to Oral Bacteria
    WHASUN CHUNG; Fiscal Year: 2008
    ..This work will lay the groundwork for identifying new therapeutic targets to prevent and treat periodontal diseases. [unreadable] [unreadable]..
  55. 2007 Antimicrobial Peptides Gordon Conference
    Richard Gallo; Fiscal Year: 2007
    ..The organizational philosophy is to encourage diverse[unreadable] participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with[unreadable] physical limitations. ..
  56. Regulation of Beta-Defensin Expression in Oral Epithelia
    WHASUN CHUNG; Fiscal Year: 2009
    ..These studies will lead to new insights on the role of innate immunity and new potential targets for therapeutic drug development for oral infections. ..
  57. c-diGMP Signal Transduction Proteins are Biofilm Drug Targets
    Timothy Opperman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  58. Regulation of Human Beta-Defensins in Epithelia
    WHASUN CHUNG; Fiscal Year: 2006
    ..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
  59. ROLE OF MONONUCLEAR LEUKOCYTES IN IMMUNITY
    Samuel Silverstein; Fiscal Year: 2009
    ..In other words, must cytotoxic lymphocytes reach a critical concentration within a tumor bed to effect a reduction in tumor mass? ..
  60. Controlled Drug Delivery to Colon Tumors Via Ultrasound
    WILLIAM PITT; Fiscal Year: 2006
    ..The research outcomes will prove hypotheses, which will become the basis for understanding and exploiting this therapy in the treatment of localized cancers, hopefully paving the way for clinical application. ..
  61. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  62. THERAPEUTIC APPROACHES TO BIOFILM ANTIBIOTIC RESISTANCE
    Timothy Opperman; Fiscal Year: 2005
    b>Staphylococcus epidermidis and Staphylococcus aureus are the leading causes of indwelling-device related infections, affecting up to 400,000 patients/year in the United States...
  63. Health Sciences Research: Educating the Public - PHASE II
    Samuel Silverstein; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..