arthrodermataceae

Summary

Summary: A family of ascomycetous fungi, order Onygenales, characterized by smooth ascospores. The two genera in the family are Arthroderma and Ctenomyces. Several well-known anamorphic forms are parasitic upon the skin.

Top Publications

  1. ncbi A study of dermatophytes and their in-vitro antifungal sensitivity
    M N Sumana
    Department of Microbiology, Govt Medical College, Mysore
    Indian J Pathol Microbiol 45:169-72. 2002
  2. ncbi Treatment of onychomycosis caused by dermatophytes--an opinion proposed by Committee for Standardization of the Japanese Society for Medical Mycology 2007
    Shinobu Mohri
    Yokohama City Hospital
    Nihon Ishinkin Gakkai Zasshi 49:1-3. 2008
  3. ncbi Disseminated nodular granulomatous perifolliculitis
    S Das
    Department of Microbiology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi 110 095, India
    Indian J Med Microbiol 25:288-90. 2007
  4. ncbi Species distribution and antifungal susceptibilities of dermatophytes during a one year period at a university hospital in Turkey
    Aydan Ozkutuk
    Department of Microbiology and Clinical Microbiology, Dokuz Eylul University School of Medicine, Inciralti Izmir, Turkey
    Mycoses 50:125-9. 2007
  5. ncbi Prevalence of dermatophytic fungal infections in children: a recent study in Anambra state, Nigeria
    E I Nweze
    Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria
    Mycopathologia 160:239-43. 2005
  6. pmc Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi
    Anke Burmester
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstrasse 11a, Jena, 07745, Germany
    Genome Biol 12:R7. 2011
  7. pmc Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Clin Microbiol 37:920-4. 1999
  8. ncbi Keratinophilic fungi of poultry farm and feather dumping soil in Tamil Nadu, India
    Periasamy Anbu
    Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, 600 025, Chennai, India
    Mycopathologia 158:303-9. 2004
  9. ncbi Successful mating of Trichophyton rubrum with Arthroderma simii
    Kazushi Anzawa
    Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan
    Med Mycol 48:629-34. 2010
  10. pmc Sequenced dermatophyte strains: growth rate, conidiation, drug susceptibilities, and virulence in an invertebrate model
    Rebecca R Achterman
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Fungal Genet Biol 48:335-41. 2011

Research Grants

Detail Information

Publications174 found, 100 shown here

  1. ncbi A study of dermatophytes and their in-vitro antifungal sensitivity
    M N Sumana
    Department of Microbiology, Govt Medical College, Mysore
    Indian J Pathol Microbiol 45:169-72. 2002
    ..Griseofulvin proved to be the best drug with a sensitivity of 94.4% followed by Miconazole (75% sensitive). Tolnaftate showed a sensitivity of 47.22%. For Clotrimazole only 30.55% of the isolates were sensitive...
  2. ncbi Treatment of onychomycosis caused by dermatophytes--an opinion proposed by Committee for Standardization of the Japanese Society for Medical Mycology 2007
    Shinobu Mohri
    Yokohama City Hospital
    Nihon Ishinkin Gakkai Zasshi 49:1-3. 2008
    ..Finally, with consideration of already published therapeutic guidelines, we stress the necessity of "order-made" therapy for each patient with his/her medical status and wishes taking into account...
  3. ncbi Disseminated nodular granulomatous perifolliculitis
    S Das
    Department of Microbiology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi 110 095, India
    Indian J Med Microbiol 25:288-90. 2007
    ..Fungal examination by direct potassium hydroxide mount and culture revealed Trichophyton rubrum. Granulomatous changes were seen on histopathological examination. The patient completely responded to systemic antifungal therapy...
  4. ncbi Species distribution and antifungal susceptibilities of dermatophytes during a one year period at a university hospital in Turkey
    Aydan Ozkutuk
    Department of Microbiology and Clinical Microbiology, Dokuz Eylul University School of Medicine, Inciralti Izmir, Turkey
    Mycoses 50:125-9. 2007
    ..In general, all antifungals were shown to be highly effective and itraconazole and naftifine appeared more active than ketoconazole and oxiconazole...
  5. ncbi Prevalence of dermatophytic fungal infections in children: a recent study in Anambra state, Nigeria
    E I Nweze
    Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria
    Mycopathologia 160:239-43. 2005
    ....
  6. pmc Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi
    Anke Burmester
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstrasse 11a, Jena, 07745, Germany
    Genome Biol 12:R7. 2011
    ....
  7. pmc Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Clin Microbiol 37:920-4. 1999
    ..The ITS1 sequences of 11 clinical isolates were also determined to identify the species, and all strains were successfully identified by comparison of their base sequences with those in the ITS1 DNA sequence database...
  8. ncbi Keratinophilic fungi of poultry farm and feather dumping soil in Tamil Nadu, India
    Periasamy Anbu
    Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, 600 025, Chennai, India
    Mycopathologia 158:303-9. 2004
    ..3%) and Geomyces pannorum (23%). Non-dermatophyte fungi were represented by 28 species belonging to 14 genera and one non-sporulating fungus...
  9. ncbi Successful mating of Trichophyton rubrum with Arthroderma simii
    Kazushi Anzawa
    Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan
    Med Mycol 48:629-34. 2010
    ..Hybrids were observed within the genotypes of four different genes, i.e., rRNA, actin, DNA topoisomerase II and cytochrome b. These results strongly suggest that T. rubrum is not an asexual or clonal species...
  10. pmc Sequenced dermatophyte strains: growth rate, conidiation, drug susceptibilities, and virulence in an invertebrate model
    Rebecca R Achterman
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Fungal Genet Biol 48:335-41. 2011
    ..These results increase our understanding of the microbiology and molecular biology of these dermatophyte strains and will be of use in advancing hypothesis-driven research about dermatophytes...
  11. ncbi Differential gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus during infection
    Peter Staib
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Junior Research Group Fundamental Molecular Biology of Pathogenic Fungi, Beutenbergstr 11a, D 07745 Jena, Germany
    Microbiology 156:884-95. 2010
    ....
  12. ncbi The new species concept in dermatophytes-a polyphasic approach
    Yvonne Gräser
    Department of Parasitology, Institute of Microbiology and Hygiene, Charite, Humboldt University, Dorotheenstr 96, 10117 Berlin, Germany
    Mycopathologia 166:239-56. 2008
    ..The molecular data require some reinterpretation of results seen in conventional phenotypic tests, but in most cases, phylogenetic insight is readily integrated with current laboratory testing procedures...
  13. pmc Gene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins
    Christophe Zaugg
    Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Av de Beaumont 29, 1011 Lausanne, Switzerland
    Eukaryot Cell 8:241-50. 2009
    ..This broad-scale transcriptional analysis of dermatophytes during growth on proteins reveals new putative pathogenicity-related host adaptation mechanisms of these human pathogenic fungi...
  14. ncbi Antifungal activity of xanthones: evaluation of their effect on ergosterol biosynthesis by high-performance liquid chromatography
    Eugénia Pinto
    Research Center of Medicinal Chemistry University of Porto CEQUIMED UP, R Anibal Cunha, 164, 4050 047, Porto, Portugal
    Chem Biol Drug Des 77:212-22. 2011
    ..In summary, 1,2-dihydroxyxanthone was found to be the most active compound against all strains tested, showing its effect on sterol biosynthesis by reducing the amount of ergosterol detected...
  15. ncbi Survey of keratinophilic fungi isolated from city park soils of Pisa, Italy
    R Papini
    Dipartimento di Clinica Veterinaria, Facolta di Medicina Veterinaria, Pisa, Italy
    Mycopathologia 143:17-23. 1998
    ..terrestre (8%), M. fulvum, Ch. luteum, Ch. indicum (5% each) and M. cookei (2%). The presence of the different species is discussed in relation to the risk of fungal skin infections...
  16. ncbi Isolation of keratinophilic fungi from soil in Isfahan province, Iran
    R Kachuei
    Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
    J Mycol Med 22:8-13. 2012
    ..To evaluate the epidemiology of keratophilic fungi in Isfahan province, Iran...
  17. ncbi Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety
    Eugénia Pinto
    Centro de Química Medicinal, Faculdade de Farmacia, Rua Anibal Cunha, 164, 4050 047 Porto, Portugal
    Bioorg Med Chem 16:8172-7. 2008
    ..Furthermore, the spectrum of activity in the pyridine derivatives was broadened by the absence of the ester group on position 2 of the benzo[b]thiophene system...
  18. ncbi Conventional methods for the diagnosis of dermatophytosis
    Raymond Robert
    Laboratoire de Parasitologie Mycologie, Faculte de Pharmacie, Groupe d Etude des Interactions Hote Pathogene, UPRES EA 3142, Universite d Angers, 16 Boulevard Daviers, 49100 Angers, France
    Mycopathologia 166:295-306. 2008
    ....
  19. ncbi Identification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic pH
    Dev Sriranganadane
    Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Proteomics 11:4422-33. 2011
    ..Our findings also suggest the existence of different pathways of protein degradation into amino acids and short peptides in these highly specialized pathogenic fungi...
  20. pmc Two different secondary metabolism gene clusters occupied the same ancestral locus in fungal dermatophytes of the arthrodermataceae
    Han Zhang
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 7:e41903. 2012
    Dermatophyte fungi of the family Arthrodermataceae (Eurotiomycetes) colonize keratinized tissue, such as skin, frequently causing superficial mycoses in humans and other mammals, reptiles, and birds...
  21. ncbi Dermatophyte infections
    Barry L Hainer
    Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am Fam Physician 67:101-8. 2003
    ..The diagnosis of onychomycosis should be confirmed by KOH microscopy, culture, or histologic examination before therapy is initiated, because of the expense, duration, and potential adverse effects of treatment...
  22. ncbi Pets as the main source of two zoonotic species of the Trichophyton mentagrophytes complex in Switzerland, Arthroderma vanbreuseghemii and Arthroderma benhamiae
    Stéphane Drouot
    Service de Dermatologie, Département Clinique de Médecine Vétérinaire, Faculté Vetsuisse, Universite de Berne, Berne, Switzerland
    Vet Dermatol 20:13-8. 2009
    ..canis. Therefore, it can be suspected that infection with A. vanbreuseghemii occurred during hunting and that the natural source of this dermatophyte is either soil or an animal other than the cat, most probably a rodent...
  23. ncbi Molecular analysis and mating behaviour of the Trichophyton mentagrophytes species complex
    Francoise Symoens
    Scientific Institute of Public Health, Mycology Aerobiology Section, Brussels, Belgium
    Int J Med Microbiol 301:260-6. 2011
    ..vanbreuseghemii tester strains, but had lost their ability to give fertile cleistothecia. Therefore, T. interdigitale has to be considered as a humanized species derived from the sexual relative A. vanbreuseghemii...
  24. ncbi First report of Arthroderma benhamiae in Switzerland
    Janine Fumeaux
    Service de Dermatologie DHURDV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Dermatology 208:244-50. 2004
    ..Identification of dermatophytes often remains difficult or uncertain because there are variations from one isolate to another and overlapping characteristics between species...
  25. pmc rRNA gene internal transcribed spacer 1 and 2 sequences of asexual, anthropophilic dermatophytes related to Trichophyton rubrum
    R C Summerbell
    Laboratories Branch, Ontario Ministry of Health, University of Toronto, Toronto, Ontario, Canada
    J Clin Microbiol 37:4005-11. 1999
    ..equinum by only 1 bp, while the ITS sequence of the recently described species T. krajdenii had a sequence identical to that of T. mentagrophytes isolates related to the teleomorph Arthroderma vanbreuseghemii...
  26. ncbi Closely related dermatophyte species produce different patterns of secreted proteins
    Karin Giddey
    Dermatology Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    FEMS Microbiol Lett 267:95-101. 2007
    ..These results suggest that a switch of habitat could be related to a differential expression of genes encoding homologous secreted proteins...
  27. ncbi Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry
    Marcel Erhard
    AnagnosTec GmbH, Am Muhlenberg, Potsdam Golm, Germany
    Exp Dermatol 17:356-61. 2008
    ..Costs for consumables as well as preparation time are considerably lower than for PCR analysis...
  28. ncbi The epidemiology and mating behavior of Arthroderma benhamiae var. erinacei in household four-toed hedgehogs (Atelerix albiventris) in Japan
    Yoko Takahashi
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan
    Nihon Ishinkin Gakkai Zasshi 44:31-8. 2003
    ..These results show that A. benhamiae var. erinacei, the teleomorph of T. mentagrophytes var. erinacei, belongs to a different mating group (e.g. hedgehog race) than the Americano-European and African races in A. benhamiae...
  29. pmc Generating and testing molecular hypotheses in the dermatophytes
    Theodore C White
    Seattle Biomedical Research Institute, 307 Westlake Ave North, Suite 500, Seattle, WA 98109 5129, USA
    Eukaryot Cell 7:1238-45. 2008
  30. ncbi Phylogeny and taxonomy of the family Arthrodermataceae (dermatophytes) using sequence analysis of the ribosomal ITS region
    Y Graser
    Institute of Microbiology and Hygiene, Department of Dermatology, Humboldt University, Berlin, Germany
    Med Mycol 37:105-14. 1999
    ..8S ribosomal DNA was used to evaluate phylogenetic relationships within the fungal family Arthrodermataceae. Sequences of variable length, ranging between 522 and 684 base pairs were aligned...
  31. ncbi Molecular approaches to the study of dermatophytes
    G Kac
    Laboratoire de Parasitologie Mycologie, Hopital Tenon, Paris, France
    Med Mycol 38:329-36. 2000
    ..In contrast, in all but a few cases distinction between dermatophyte strains has failed, which has hindered the development of molecular-based epidemiological investigations...
  32. ncbi PCR-based identification of common dermatophyte species using primer sets specific for the DNA topoisomerase II genes
    Toshio Kanbe
    Laboratory of Medical Mycology, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Aichi 466 8550, Nagoya, Japan
    J Dermatol Sci 32:151-61. 2003
    ..We have determined nucleotide sequences of the DNA topoisomerase II genes of the dermatophyte species, and conducted a PCR-based identification system using species-specific primers for the nucleotide sequences...
  33. pmc Repetitive-sequence-PCR-based DNA fingerprinting using the Diversilab system for identification of commonly encountered dermatophytes
    June I Pounder
    ARUP, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    J Clin Microbiol 43:2141-7. 2005
    ..canis-was excellent. Moreover, the DiversiLab system is technically simple and provides results in < 24 h once a pure culture is available for testing, which is considerably more rapid than conventional identification tests...
  34. ncbi Molecular taxonomy of dermatophytes and related fungi by chitin synthase 1 (CHS1) gene sequences
    Asuka Hirai
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Antonie Van Leeuwenhoek 83:11-20. 2003
    ..The molecular taxonomy of the CHS1 gene sequences revealed that Microsporum was genetically distinct from Chrysosporium and Trichophyton, as classified by morphological characteristics...
  35. ncbi Antifungal resistance mechanisms in dermatophytes
    Nilce M Martinez-Rossi
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Mycopathologia 166:369-83. 2008
    ....
  36. ncbi Chitin synthase 1 gene of Arthroderma benhamiae isolates in Japan
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Fujisawa, Kanagawa, 252 8510, Japan
    Mycoses 45:277-81. 2002
    ..benhamiae were included in the same cluster, and that the African race of A. benhamiae formed a cluster that was distinct from the Americano-European race of A. benhamiae, A. simii and A. vanbreuseghemii...
  37. pmc Use of the sensititre colorimetric microdilution panel for antifungal susceptibility testing of dermatophytes
    I Pujol
    Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus Unitat de Microbiologia, Facultat de Medicina Institut d Estudis Avançats, Universitat Rovira i Virgili, Reus, Tarragona, Spain
    J Clin Microbiol 40:2618-21. 2002
    ..The levels of agreement between the two methods (<or=2 dilutions) were 81.6% with amphotericin B, 87.7% with itraconazole, 67.3% with fluconazole, and 69.4% with ketoconazole...
  38. pmc Analysis of the dermatophyte Trichophyton rubrum expressed sequence tags
    Lingling Wang
    State Key Lab for Molecular Virology and Genetic Engineering, Beijing 100176, China
    BMC Genomics 7:255. 2006
    ..It is therefore necessary to identify genes whose expression is relevant to growth, metabolism and virulence of T. rubrum...
  39. ncbi Eastern cottontail (sylvilagus floridanus) as carrier of dermatophyte fungi
    M G Gallo
    Department of Animal Production Epidemiology and Ecology, University of Turin, Grugliasco, TO, Italy
    Mycopathologia 160:163-6. 2005
    ..As Eastern cottontail has been showed to be a carrier of dermatophytes transmissible to man (M. canis, T. mentagrophytes and M. gypseum), it may represent a source of infection for gamekeepers, hunters and veterinarians...
  40. ncbi Survey of dermatophytes on clinically normal cats in the southeast of England
    A Patel
    Dermatology Unit, Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, Hertfordshire
    J Small Anim Pract 46:436-9. 2005
    ..Asymptomatic cats are often blamed for transmission of dermatophytes between animals and humans. This study may help to clarify whether cats are responsible for the increase in fungal infections among the human population...
  41. ncbi [Enzyme activities of dermatophytes isolated from different clinical samples by ApiZYM method]
    Nurver Ulger Toprak
    Marmara Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Istanbul
    Mikrobiyol Bul 39:183-9. 2005
    ..001). The results of this study suggest that alpha-mannosidase activity may play a role in both cutaneous inflammatory response caused by dermatophytes and the chronicity of the lesions...
  42. ncbi Seasonal 4-year investigation into the role of the alpine marmot (Marmota marmota) as a carrier of zoophilic dermatophytes
    M G Gallo
    Dipartimento di Produzioni Animali, Epidemiologia ed Ecologia, Sezione Parassitologia e Malattie Parassitarie, Grugliasco, Turin, Italy
    Med Mycol 43:373-9. 2005
    ..This seems to be confirmed by the fact that the fungus has never been found in the control samples collected at a distance of 300 m from the outer edge of the sampled burrow systems...
  43. ncbi Dermatophytes growth curve and in vitro susceptibility test: a broth micro-titration method
    A B Alió
    Dermatology Department and Mycology Laboratory, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela
    Med Mycol 43:319-25. 2005
    ..Fluconazole demonstrated no efficacy. Our MIC results differ from other authors and this difference is due to the timing of the MIC determination based on the growth curve of each fungi tested...
  44. ncbi [In vitro antifungal activity of voriconazole against dermatophytes and superficial isolates of Scopulariopsis brevicaulis]
    Alfonso Javier Carrillo-Muñoz
    Departamento de Microbiologia, ACIA, Apartado Postal 10178, E 08080, Barcelona, Spain
    Rev Iberoam Micol 22:110-3. 2005
    ..However, S. brevicaulis isolates were highly resistant to all azoles used in this study. Voriconazole might be an interesting antifungal alternative to refractory superficial mycoses...
  45. ncbi Antifungal susceptibilities of dermatophytic agents isolated from clinical specimens
    Zafer Cetinkaya
    Afyon Kocatepe University, Faculty of Medicine, Department of Microbiology, Afyon, Turkey
    Eur J Dermatol 15:258-61. 2005
    ....
  46. ncbi Neonatal cutaneous fungal infections
    Kara N Smolinski
    Division of Emergency Medicine, and Section of Pediatric Dermatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 17:486-93. 2005
    ....
  47. ncbi Ethnoveterinary medicine in the search for antimicrobial agents: antifungal activity of some species of Pterocaulon (Asteraceae)
    Ana Cristina Stein
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul Av Ipiranga 2752, 90610 000 Porto Alegre, RS, Brazil
    J Ethnopharmacol 99:211-4. 2005
    ..Pterocaulon balansae crude methanolic extract was the less active but its lipophilic fractions showed remarkable activity mainly against the dermatophytes...
  48. ncbi Dermatophyte infections in the Ljubljana region, Slovenia, 1995-2002
    Mateja Dolenc-Voljc
    Department of Dermatovenereology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
    Mycoses 48:181-6. 2005
    ..During the period studied, we recorded a decline in the rate of M. canis infections, while infections produced by T. rubrum increased in frequency...
  49. ncbi PCR-RFLP analysis of the dermatophytes isolated from patients in Central Poland
    Anita Dobrowolska
    J Dermatol Sci 42:71-4. 2006
  50. ncbi Onychomycosis incidence in type 2 diabetes mellitus patients
    Patricia Manzano-Gayosso
    Laboratorio de Micologia Medica, Departamento de Microbiologia y Parasitologia, Facultad de Medicina, UNAM, Ciudad Universitaria, Mexico, CP 04510, DF, Mexico
    Mycopathologia 166:41-5. 2008
    ..The fungal mixture corresponded to T. mentagrophytes with C. guilliermondii; T. mentagrophytes with C. glabrata; T. rubrum with C. glabrata; T. rubrum with P. ohmeri...
  51. ncbi Terbinafine susceptibility patterns for onychomycosis-causative dermatophytes and Scopulariopsis brevicaulis
    Alfonso Javier Carrillo-Muñoz
    Departamento de Microbiologia, ACIA, P O Box 10178, E 08080 Barcelona, Spain
    Int J Antimicrob Agents 31:540-3. 2008
    ..The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions...
  52. ncbi A 7-year survey of dermatophytoses in Crete, Greece
    Sofia Maraki
    Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Crete, Crete, Greece
    Mycoses 50:481-4. 2007
    ..Trichophyton rubrum is the predominant dermatophyte in our area. As the epidemiology of dermatophytoses is changing over time it is important to review periodically the incidence of dermatophytes and their distribution...
  53. ncbi In vitro activity of voriconazole against dermatophytes, Scopulariopsis brevicaulis and other opportunistic fungi as agents of onychomycosis
    A J Carrillo-Munoz
    Departamento de Microbiologia, ACIA, PO Box 10178, E 08010 Barcelona, Spain
    Int J Antimicrob Agents 30:157-61. 2007
    ..52 microg/mL; MIC(50) and MIC(90)=16 microg/mL). Although voriconazole is not among the drugs recommended for the management of onychomycosis, it can be a useful alternative for recalcitrant infections...
  54. ncbi Analysis of the dermatophyte species isolated in the British Isles between 1980 and 2005 and review of worldwide dermatophyte trends over the last three decades
    Andrew M Borman
    Health Protection Agency, Mycology Reference Laboratory, Bristol, UK
    Med Mycol 45:131-41. 2007
    ....
  55. ncbi Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species
    Eugénia Pinto
    Department of Microbiology CEQOFF, Faculty of Pharmacy, University of Porto, 4050 Porto, Portugal
    J Med Microbiol 55:1367-73. 2006
    ..The present study indicates that T. pulegioides essential oil has considerable antifungal activity, deserving further investigation for clinical applications...
  56. ncbi In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes
    Masoomeh Shams-Ghahfarokhi
    Department of Mycology, Faculty of Medical Sciences, Tarbiat Modarress University, Tehran 14115 111, Iran
    Fitoterapia 77:321-3. 2006
    ..The results indicate that onion and garlic might be promising in treatment of fungal-associated diseases from important pathogenic genera Candida, Malassezia and the dermatophytes...
  57. ncbi Dermatophyte growth and degradation of human stratum corneum in vitro (pathogenesis of dermatophytosis)
    Azam Jah Samdani
    King Abdul Aziz Hospital, Makkah, Saudi Arabia
    J Ayub Med Coll Abbottabad 17:19-21. 2005
    ..This study was carried out to determine growth of dermatophytes using human stratum corneum in vitro and the degrading effect of Keratinases (Proteinases) on stratum corneum for a complete understanding of the host parasite relationship...
  58. ncbi How do dermatophytes survive in the epidermis?
    Roderick J Hay
    Curr Opin Infect Dis 19:125-6. 2006
  59. ncbi Physicochemical modification of the excretion product of Saccharomyces cerevisiae killer strains results in fungicidal activity against Candida albicans and Tricophyton mentagrophytes
    Nelson Bracesco
    Lab Radiobiología Dpt Biofísica Facultades de Medicina y Ciencias, Univ de la República Uruguay
    FEMS Microbiol Lett 256:132-6. 2006
    ..5 degrees C). It was significantly lethal against Candida albicans and Tricophyton mentagrophytes. SKF showed stability and activity after storage, with a mean half-life of 6 months at 4 degrees C or at -20 degrees C...
  60. ncbi Characteristics of dermatophytoses among children in an area south of Tehran, Iran
    A Rastegar Lari
    Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran
    Mycoses 48:32-7. 2005
    ..rubrum (13.2%), T. mentagrophytes (11.3%), M. gypseum (7.5%), and T. verrucosum (5.7%). Tinea capitis (39.6%) was the most common type of infection, followed by tinea corporis (30.2%), tinea faciei (18.9%), and tinea manuum (7.5%)...
  61. pmc Allergy and dermatophytes
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, P O Box 801355, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Clin Microbiol Rev 18:30-43. 2005
    ..Characterization of additional molecular targets by using new techniques may aid not only in the eradication of infection but also in the resolution of allergic symptoms...
  62. ncbi In vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates
    A J Carrillo-Munoz
    Department of Microbiology, ACIA, Barcelona, Spain
    J Chemother 15:555-7. 2003
    ..59 microg/ml). Considering MIC50 and MIC90 these differences were significantly in favor of the activity of sertaconazole against E. floccosum (0.06 and 0.5 microg/ml respectively)...
  63. ncbi Toenail onychomycosis in Estonia
    H Järv
    Department of Clinical Microbiology, United Laboratories, Tartu University Clinics
    Mycoses 47:57-61. 2004
    ....
  64. ncbi Dermatophyte-related granular parakeratosis
    Kenneth S Resnik
    Institute for Dermatopathology, Conshohocken, PA 19428, USA
    Am J Dermatopathol 26:70-1. 2004
    ..Biopsies of this process revealed dermatophytosis and concurrent granular parakeratosis. This patient's eruption resolved completely with antifungal therapy suggesting that the fungal organisms caused the granular parakeratosis...
  65. ncbi In vitro activity of sertaconazole against dermatophyte isolates with reduced fluconazole susceptibility
    A J Carrillo-Munoz
    Department of Microbiology, ACIA, Barcelona, Spain
    Chemotherapy 49:248-51. 2003
    ..None of the isolates was resistant to sertaconazole during the study while for four isolates the MIC of fluconazole was >/=64 microg/ml. No evidence of cross-resistance between both antifungals was found...
  66. ncbi Flurbiprofen, a unique non-steroidal anti-inflammatory drug with antimicrobial activity against Trichophyton, Microsporum and Epidermophyton species
    B Chowdhury
    Department of Biology, Memorial University of Newfoundland, St John s, Newfoundland A1B 3X9, Canada
    Lett Appl Microbiol 37:158-61. 2003
    ..The objective of this study was to determine the antifungal activity of flurbiprofen against dermatophytes like Trichophyton, Microsporum and Epidermophyton species...
  67. pmc Clinical benefit of recovering dermatophytes from skin swabs sent for bacterial culture
    Gillian Mabbott
    Department of Microbiology, Diagnostic Medlab, Panmure, Auckland, New Zealand
    J Clin Microbiol 42:4838-9. 2004
    ..3%) of 22,613 cultures. Twenty-one patients received specific antifungal treatment when their dermatophyte was reported. Most clinicians thought recovering and reporting the dermatophyte contributed to patient management...
  68. ncbi Dermatophytes in the rural area of Duzce, Turkey
    Idris Sahin
    Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Abant Izzet Baysal University, Duzce, Turkey
    Mycoses 47:470-4. 2004
    ..This is the first paper to report the prevalence of fungal infections in Duzce, a western Black Sea region of Turkey...
  69. ncbi In vitro evaluation of griseofulvin against clinical isolates of dermatophytes from Isfahan
    Mostafa Chadeganipour
    Mycology and Parasitology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Mycoses 47:503-7. 2004
    ..At least some of the isolates tested might be difficult to eradicate in clinical terms with griseofulvin treatment in Isfahan...
  70. ncbi Inhibition of dermatophytes by optical brighteners
    J Brasch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Mycoses 46:120-5. 2003
    ..Optical brighteners of stilbenedisulfonic acid type may be rewarding objects for the development of new antifungal agents...
  71. ncbi Anti dermatophytic activity of Azardirachta indica (neem) by invitro study
    V Natarajan
    Departments of Microbiology and Dermatology, Rajah Muthiah Medical College, Annamalai University, Annamalai Nagar, Tamil Nadu
    Indian J Pathol Microbiol 45:311-3. 2002
    ..The minimum Inhibitory concentration (MIC) of neem seed extract was found to be lower tan that of neem leaf when tested against different species of Dermatophytes...
  72. ncbi In vitro antagonistic activity of monoterpenes and their mixtures against 'toe nail fungus' pathogens
    Russel S Ramsewak
    Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Phytother Res 17:376-9. 2003
    ..The MIC(100) for mixtures of these four components in various carrier solvents revealed that formulations consisting of 5 mg/mL concentrations of each have a potential to be efffective in controlling onychomycosis...
  73. ncbi [Modern antimycotics. What the treating physician needs to know]
    C Seebacher
    Dresden, Germany
    Hautarzt 55:150-6. 2004
    ..Preadolescent children do not have functioning sebaceous glands; this explains the difficulties in the treatment of pediatric tinea capitis...
  74. ncbi An isolate of Arthroderma benhamiae with Trichophyton mentagrophytes var. erinacei anamorph isolated from a four-toed hedgehog (Atelerix albiventris) in Japan
    Yoko Takahashi
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8673, Japan
    Nihon Ishinkin Gakkai Zasshi 43:249-55. 2002
    ..mentagrophytes var. erinacei (DDBJ/EMBL/GenBank accession numbers Z97996 and Z97997) by more than 99.7%. Therefore, our case is the first isolation of A. benhamiae with T. mentagrophytes var. erinacei anamorph in Japan...
  75. ncbi Terbinafine is more effective than itraconazole in treating toenail onychomycosis: results from a meta-analysis of randomized controlled trials
    Alexander H Krob
    Westwood Squibb Center for Dermatology Research, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1071, USA
    J Cutan Med Surg 7:306-11. 2003
    ....
  76. ncbi In vitro modulation of human keratinocyte pro- and anti-inflammatory cytokine production by the capsule of Malassezia species
    Daniel S Thomas
    Skin Research Centre, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK
    FEMS Immunol Med Microbiol 54:203-14. 2008
    ..001). These results support the hypothesis that the lipid layer of Malassezia spp. modulates cytokine production by keratinocytes. This has implications in the pathogenesis of seborrhoeic dermatitis...
  77. pmc Lobomycosis in offshore bottlenose dolphins (Tursiops truncatus), North Carolina
    David S Rotstein
    National Oceanic and Atmospheric Administration, Silver Springs, Maryland, USA
    Emerg Infect Dis 15:588-90. 2009
    ....
  78. ncbi Evaluation of internal transcribed spacer 2-RFLP analysis for the identification of dermatophytes
    Thierry de Baere
    Laboratory for Bacteriology Research, University of Ghent, Ghent, Belgium
    J Med Microbiol 59:48-54. 2010
    ....
  79. ncbi Epidemiological and mycological data of onychomycosis in Goiania, Brazil
    L K H Souza
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Goiania, Brazil
    Mycoses 53:68-71. 2010
    ..Trichosporon sp., Geotrichum sp. and Fusarium sp. In our study, yeast of the genus Candida were the dominant cause of onychomycosis in women and dermatophytes were the principal cause of this condition in men...
  80. ncbi Value of the ethnomedical information for the discovery of plants with antifungal properties. A survey among seven Latin American countries
    Laura Svetaz
    Farmacognosia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Rosario, Argentina
    J Ethnopharmacol 127:137-58. 2010
    ....
  81. ncbi Mechanisms of skin adherence and invasion by dermatophytes
    A Baldo
    Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    Mycoses 55:218-23. 2012
    ..To date, research on mechanisms of dermatophyte infection focused mainly on both secreted endoproteases and exoproteases, but their precise role in both fungal adherence and skin invasion should be further explored...
  82. ncbi Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
    Fernando D Suvire
    Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis U N S L, Chacabuco 917, 5700 San Luis, Argentina
    Bioorg Med Chem 14:1851-62. 2006
    ..Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties...
  83. ncbi Synthesis, in vitro/in vivo antifungal evaluation and structure-activity relationship study of 3(2H)-pyridazinones
    László Károlyházy
    Departement of Organic Chemistry, Semmelweis University, Budapest, Hungary
    Arzneimittelforschung 53:738-43. 2003
    ....
  84. pmc Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets
    Deepu Alex
    Georgetown University Medical Center, Washington, DC, USA
    Antimicrob Agents Chemother 56:4630-9. 2012
    ..Also, the same compound has activity when cells are grown in a medium containing glycerol (mitochondrial substrate) but is much less active when cells are grown anaerobically...
  85. ncbi Identification of dermatophytes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Sophie De Respinis
    Institute of Microbiology, Via Mirasole 22A, 6501 Bellinzona, Switzerland
    Med Mycol 51:514-21. 2013
    ..8%) strains were correctly identified by MALDI-TOF MS compared to 128/141 (90.8%) by morphology. Therefore, MALDI-TOF MS has proven to be a useful and rapid identification method for dermatophytes...
  86. pmc PCR fingerprinting for identification of common species of dermatophytes
    Elisabetta Faggi
    J Clin Microbiol 40:4804-5. 2002
  87. ncbi Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones
    Paula Boeck
    Departamento de Quimica, Universidade Federal de Santa Catarina, Florianopolis, Brasil
    Arch Pharm (Weinheim) 338:87-95. 2005
    ..This work strongly contributes to the knowledge of the antifungal properties of hydroxy-chalcones...
  88. ncbi Sertaconazole antifungal profile determined by a microdilution method versus nine topical substances against dermatophyte fungi
    A J Carrillo-Munoz
    Department of Microbiology Mycology, ACIAM, Barcelona, Spain
    Chemotherapy 58:399-404. 2012
    ....
  89. pmc Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis
    T Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Br J Dermatol 158:1239-46. 2008
    ..Topical application of germicidal ultraviolet (UV) C radiation may be an acceptable and effective therapy for infected nails...
  90. ncbi Differentiating the dermatophytes
    Jeremy R Caddell
    Mayo Foundation, Rochester, MN 55905, USA
    Clin Lab Sci 15:13-5. 2002
  91. ncbi The diagnostic value of fungal fluorescence in onychomycosis
    Munir H Idriss
    Ackerman Academy of Dermatology, New York, NY 10016, USA
    J Cutan Pathol 40:385-90. 2013
    ..We hypothesize that this phenomenon could aid in the evaluation of nail specimens for onychomycosis...
  92. ncbi Tinea incognito in children: 54 cases
    J del Boz
    Department of Dermatology of the Hospital Costa del Sol Marbella, Marbella, Spain
    Mycoses 54:254-8. 2011
    ..4%). This is the largest case series of childhood TI reported to date. TI has increased over recent years and important differences were found between these TI and the other tineas in children over the same period...
  93. ncbi Presence of dermatophytes on the nails of tinea capitis patients. Prospective study in the area of Sfax (Tunisia)
    F Cheikhrouhou
    Laboratory of Parasitology Mycology, Sfax Faculty of Medicine, Sfax, Tunisia
    Mycoses 46:334-5. 2003
    ..Dermatophyte colonization of the nails in tinea patients could be a factor of tinea capitis transmission and could explain some recurrent tinea capitis cases and therapy resistance...
  94. ncbi Antifungal activity of sakurasosaponin from the root extract of Jacquinia flammea
    K García-Sosa
    Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No 130 Col Chuburná de Hidalgo, Merida, Yucatan, 97200 México
    Nat Prod Res 25:1185-9. 2011
    ....
  95. ncbi Common fungal infections of the feet in patients with diabetes mellitus
    James S Tan
    Department of Internal Medicine, Northeastern Ohio Universities College of Medicine, Ohio, USA
    Drugs Aging 21:101-12. 2004
    ..Over the past decade, fungal foot infections of the skin and nail are more effectively treated with the introduction of numerous topical and oral agents...
  96. ncbi Antifungal Activity of the Essential Oils of Callitris neocaledonica and C. sulcata Heartwood (Cupressaceae)
    Jean Waikedre
    UMR217, Laboratoire Substances Naturelles Terrestres and Savoirs Traditionnels SNT and ST, IRD, BP A5, 98848, Noumea, Nouvelle Calédonie
    Chem Biodivers 9:644-53. 2012
    ..2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity. C. neocaledonica essential oil was more active than C. sulcata oil (93.3 vs. 32.2% DPPH(.) scavenged at 250 μg/ml)...
  97. ncbi Antidermatophytic action of new 1-naphthylmethyl and benzo[b]thiophen-7-ylmethyl hydrazones related to inhibitors of squalene epoxidase
    L Auzzas
    Dipartimento Farmaco Chimico Tossicologico, University of Sassari, Italy
    Pharmazie 55:483-9. 2000
    ....
  98. ncbi [In vitro antifungal activity of mercurobutol]
    P Boiron
    Unite de Mycologie, Institut Pasteur, Paris, France
    Pathol Biol (Paris) 38:719-22. 1990
    ..Minimal inhibitory concentrations on this antiseptic indicate a high susceptibility of the species tested, that could justify the enlargement of the indication of the drug to the complementary treatment of most cutaneous mycosis...
  99. ncbi Two arthroderma benhamiae isolates showing mitochondrial DNA type of Trichophyton verrucosum
    Masako Kawasaki
    Department of Dermatology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Nihon Ishinkin Gakkai Zasshi 43:103-6. 2002
    ..benhamiae African race. These results suggest that there are three genetic types of A. benhamiae - an Americano-European type, an African type and a T. verrucosum type - and that T. verrucosum is an anamorph of A. benhamiae...
  100. pmc Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay
    Bertrand Favre
    Novartis Research Institute, Vienna, Austria
    J Clin Microbiol 41:4817-9. 2003
    ..Terbinafine was the most potent systemic drug while tolnaftate and amorolfine were the most active topical agents...
  101. pmc Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans
    Wen Bing Yin
    Department of Chemical and Biomolecular Engineering and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States
    ACS Synth Biol 2:629-34. 2013
    ..When integrated into the model Aspergillus nidulans host, a structurally related compound neosartoricin B was formed, suggesting a possible role of this compound in the pathogenesis of these strains...

Research Grants9

  1. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..abstract_text> ..
  2. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006
    ..abstract_text> ..
  3. Azoles and Candida in AIDS - A Whole Cell Response
    THEODORE WHITE; Fiscal Year: 2004
    ....
  4. In Vivo Expression of Candida Drug Resistance Genes
    THEODORE WHITE; Fiscal Year: 2004
    ..abstract_text> ..
  5. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    ..albicans biofilms. By studying biofilm model systems and applying this knowledge to the patient population, we will gain a wealth of data about the biology and drug resistance of C. albicans in biofilms. ..
  6. Azoles and Candida in AIDS-Transcriptional Regulation
    THEODORE WHITE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. MECHANISM OF IL-12 INHIBITION BY CANDIDA ALBICANS
    Mahmoud Ghannoum; Fiscal Year: 2009
    ..Data obtained from these studies will lead to a better understanding of the complex immune response to CA infection and may identify novel prevention/treatment strategies for candidiasis. ..
  8. AIDS Related Oral Candidiasis: Drugs, Sterols, and Fungal Cells
    Theodore C White; Fiscal Year: 2010
    ..Understanding the interactions between azoles and fungal cells is a clinically significant issue, with the potential for improving diagnosis, treatment and prevention of fungal infections and resistance. ..
  9. AIDS Related Candidiasis: Dynamic Expression of Drug Resistant Genes
    Theodore C White; Fiscal Year: 2010
    ..This has clinical significance, as fungi in a patient are never simply exposed to one defined set of drug/fungus conditions. ..