candida glabrata

Summary

Summary: A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.

Top Publications

  1. pmc Candida glabrata PHO4 is necessary and sufficient for Pho2-independent transcription of phosphate starvation genes
    Christine L Kerwin
    Department of Biology, Villanova University, Villanova, PA19085, USA
    Genetics 182:471-9. 2009
  2. ncbi Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med 125:S3-13. 2012
  3. pmc The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
    Diane O Inglis
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D667-74. 2012
  4. pmc Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia
    Jong Hee Shin
    Department of Laboratory Medicine, Chonnam National University Medical School, 8 Hakdong Dongku, Gwangju 501 757, South Korea
    J Clin Microbiol 45:2385-91. 2007
  5. ncbi Mixed Candida albicans and Candida glabrata populations associated with the pathogenesis of denture stomatitis
    B J Coco
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland, UK
    Oral Microbiol Immunol 23:377-83. 2008
  6. ncbi The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation
    Katja Seider
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, 07745 Jena, Germany
    J Immunol 187:3072-86. 2011
  7. pmc Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice
    Sélène Ferrari
    Institute of Microbiology, University of Lausanne and University Hospital Center, Rue du Bugnon 48, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 55:1852-60. 2011
  8. pmc Recognition of yeast by murine macrophages requires mannan but not glucan
    Sabine Keppler-Ross
    Department of Biochemistry and Cell Biology, Stony Brook University, NY 11794, USA
    Eukaryot Cell 9:1776-87. 2010
  9. pmc Coevolution within a transcriptional network by compensatory trans and cis mutations
    Dwight Kuo
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
    Genome Res 20:1672-8. 2010
  10. ncbi Proteomics of drug resistance in Candida glabrata biofilms
    C Jayampath Seneviratne
    Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong
    Proteomics 10:1444-54. 2010

Detail Information

Publications242 found, 100 shown here

  1. pmc Candida glabrata PHO4 is necessary and sufficient for Pho2-independent transcription of phosphate starvation genes
    Christine L Kerwin
    Department of Biology, Villanova University, Villanova, PA19085, USA
    Genetics 182:471-9. 2009
    Comparative genomic analyses of Candida glabrata and Saccharomyces cerevisiae suggest many signal transduction pathways are highly conserved. Focusing on the phosphate signal transduction (PHO) pathway of C...
  2. ncbi Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med 125:S3-13. 2012
    ..Candidemia due to Candida glabrata is becoming increasingly common, and C glabrata isolates are increasingly resistant to both azole and ..
  3. pmc The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
    Diane O Inglis
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D667-74. 2012
    ..All of these data are freely available at http://www.candidagenome.org/. We welcome feedback from the research community at candida-curator@lists.stanford.edu...
  4. pmc Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia
    Jong Hee Shin
    Department of Laboratory Medicine, Chonnam National University Medical School, 8 Hakdong Dongku, Gwangju 501 757, South Korea
    J Clin Microbiol 45:2385-91. 2007
    We examined the changes in genotypes and azole susceptibilities among sequential bloodstream isolates of Candida glabrata during the course of fungemia and the relationship of these changes to antifungal therapy...
  5. ncbi Mixed Candida albicans and Candida glabrata populations associated with the pathogenesis of denture stomatitis
    B J Coco
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland, UK
    Oral Microbiol Immunol 23:377-83. 2008
    ..The aim of this study was to examine the mycological ecology in patients with denture stomatitis, using an improved sampling technique, to determine whether species diversity and species quantity were related to oral pathology...
  6. ncbi The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation
    Katja Seider
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, 07745 Jena, Germany
    J Immunol 187:3072-86. 2011
    Although Candida glabrata is an important human pathogenic yeast, its pathogenicity mechanisms are largely unknown...
  7. pmc Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice
    Sélène Ferrari
    Institute of Microbiology, University of Lausanne and University Hospital Center, Rue du Bugnon 48, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 55:1852-60. 2011
    Mitochondrial dysfunction is one of the possible mechanisms by which azole resistance can occur in Candida glabrata. Cells with mitochondrial DNA deficiency (so-called "petite mutants") upregulate ATP binding cassette (ABC) transporter ..
  8. pmc Recognition of yeast by murine macrophages requires mannan but not glucan
    Sabine Keppler-Ross
    Department of Biochemistry and Cell Biology, Stony Brook University, NY 11794, USA
    Eukaryot Cell 9:1776-87. 2010
    ..b>Candida glabrata and Saccharomyces cerevisiae are taken up by J774 macrophage cells more rapidly than C. albicans, and C...
  9. pmc Coevolution within a transcriptional network by compensatory trans and cis mutations
    Dwight Kuo
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
    Genome Res 20:1672-8. 2010
    ..We pinpoint a single species, the fungal pathogen Candida glabrata, in which a trans mutation has occurred very recently in a single AP-1 family member, distinguishing it from ..
  10. ncbi Proteomics of drug resistance in Candida glabrata biofilms
    C Jayampath Seneviratne
    Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong
    Proteomics 10:1444-54. 2010
    b>Candida glabrata is a fungal pathogen that causes a variety of mucosal and systemic infections among compromised patient populations with higher mortality rates...
  11. pmc Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing
    Tracy Nevitt
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 7:e1001322. 2011
    The fungal pathogen Candida glabrata has risen from an innocuous commensal to a major human pathogen that causes life-threatening infections with an associated mortality rate of up to 50%...
  12. pmc A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata
    Rupinder Kaur
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Hunterian 617, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 104:7628-33. 2007
    b>Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C. glabrata with macrophages...
  13. pmc Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei
    Chiatogu Onyewu
    Departments of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 47:956-64. 2003
    ....
  14. pmc Intestinal resident yeast Candida glabrata requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine
    Keigo Ueno
    Medical Mycology Research Center MMRC, Chiba University, Chiba, Japan
    PLoS ONE 6:e24759. 2011
    The intestinal resident Candida glabrata opportunistically infects humans. However few genetic factors for adaptation in the intestine are identified in this fungus. Here we describe the C...
  15. pmc Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata
    Sélène Ferrari
    Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland
    PLoS ONE 6:e17589. 2011
    In Candida glabrata, the transcription factor CgPdr1 is involved in resistance to azole antifungals via upregulation of ATP binding cassette (ABC)-transporter genes including at least CgCDR1, CgCDR2 and CgSNQ2...
  16. pmc The antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasm
    A Brian Mochon
    Department of Biological Chemistry, University of California, Irvine, CA, USA
    PLoS Pathog 4:e1000190. 2008
    ..This mechanism of cell membrane disruption may provide species-specific killing with minimal damage to microflora and the host and may be used by many other antimicrobial peptides...
  17. pmc Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata
    Samantha C Halliwell
    School of Biology, University of Nottingham, University Park, Nottingham, United Kingdom
    Eukaryot Cell 11:141-50. 2012
    ..the relevance of gene expression heterogeneity to virulence properties of a major fungal pathogen, Candida glabrata. The organism's key virulence-associated factors include glycosylphosphatidylinositol-anchored adhesins, ..
  18. ncbi Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae
    K A Hammer
    Microbiology Discipline, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley
    J Antimicrob Chemother 53:1081-5. 2004
    The aim of this study was to investigate the mechanism of action of tea tree oil and its components against Candida albicans, Candida glabrata and Saccharomyces cerevisiae.
  19. ncbi Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, Nagasaki, Japan
    FEMS Yeast Res 10:343-52. 2010
    ..of SLT2 deletion and overexpression on drug susceptibility and virulence in the opportunistic fungal pathogen Candida glabrata. While the Deltaslt2 strain showed decreased tolerance to elevated temperature and cell wall-damaging agents, ..
  20. pmc Uneven distribution of mating types among genotypes of Candida glabrata isolates from clinical samples
    Sylvain Brisse
    Institut Pasteur, Genotyping of Pathogens and Public Health, F 75015 Paris, France
    Eukaryot Cell 8:287-95. 2009
    In order to shed light on its basic biology, we initiated a population genetic analysis of Candida glabrata, an emerging pathogenic yeast with no sexual stage yet recognized...
  21. pmc Regulation of Candida glabrata oxidative stress resistance is adapted to host environment
    Andreas Roetzer
    Max F Perutz Laboratories, University of Vienna, Department of Biochemistry, Vienna, Austria
    FEBS Lett 585:319-27. 2011
    The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species...
  22. pmc FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance
    Alicia J Zimbeck
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop G 11, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 54:5042-7. 2010
    b>Candida glabrata is the second leading cause of candidemia in the United States...
  23. pmc Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 54:1639-43. 2010
    A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence...
  24. pmc Multilocus sequence typing of Candida glabrata reveals geographically enriched clades
    Andrew R Dodgson
    School of Medicine, University of Manchester, Manchester, United Kingdom
    J Clin Microbiol 41:5709-17. 2003
    The haploid pathogenic yeast Candida glabrata is the second most common Candida species isolated from cases of bloodstream infection. The clinical relevance of C. glabrata is enhanced by its reduced susceptibility to fluconazole...
  25. pmc Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth
    Patrick Vandeputte
    Groupe d Etude des Interactions Hôte Parasite, UPRES EA 3142, Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49933 Angers Cedex 9, France
    Antimicrob Agents Chemother 51:982-90. 2007
    ..A clinical isolate of Candida glabrata with a poor susceptibility to polyenes, as determined by disk diffusion method and confirmed by determination ..
  26. ncbi Functional characterization of the CgPGS1 gene reveals a link between mitochondrial phospholipid homeostasis and drug resistance in Candida glabrata
    Monika Batova
    Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynska dolina B 2, 842 15 Bratislava 4, Slovak Republic
    Curr Genet 53:313-22. 2008
    ..To assess their role in mitochondrial and cellular functions in the pathogenic yeast Candida glabrata, a functional characterization of the CgPGS1 gene encoding the phosphatidylglycerolphosphate synthase has ..
  27. pmc Multicenter evaluation of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization method for simultaneous dual-color identification of C. albicans and C. glabrata directly from blood culture bottles
    Janeen R Shepard
    AdvanDx, Inc, 10A Roessler Road, Woburn, MA 01801, USA
    J Clin Microbiol 46:50-5. 2008
    We evaluated the performance of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization (PNA FISH) method, a rapid two-color assay for detection of C. albicans and C. glabrata, in a multicenter study...
  28. pmc Live Candida albicans suppresses production of reactive oxygen species in phagocytes
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA
    Infect Immun 77:405-13. 2009
    ..Live C. albicans also suppressed ROS in response to external stimuli. C. albicans and Candida glabrata suppressed ROS production by phagocytes, whereas Saccharomyces cerevisiae stimulated ROS production...
  29. ncbi Genomic polymorphism in the population of Candida glabrata: gene copy-number variation and chromosomal translocations
    Héloïse Muller
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, UPMC Univ Paris 06, CNRS URA 2171, 25 rue du Dr Roux, Paris, France
    Fungal Genet Biol 46:264-76. 2009
    The genomic sequence of the type strain of the opportunist human pathogen Candida glabrata (CBS138, ATCC 2001) is available since 2004. This allows the analysis of genomic structure of other strains by comparative genomic hybridization...
  30. pmc Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy
    I D Jacobsen
    Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    Infect Immun 78:1066-77. 2010
    b>Candida glabrata has emerged as an important fungal pathogen of humans, causing life-threatening infections in immunocompromised patients. In contrast, mice do not develop disease upon systemic challenge, even with high infection doses...
  31. pmc Autophagy supports Candida glabrata survival during phagocytosis
    Andreas Roetzer
    Department of Biochemistry and Cell Biology, Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Cell Microbiol 12:199-216. 2010
    The opportunistic human fungal pathogen Candida glabrata is confronted with phagocytic cells of the host defence system. Survival of internalized cells is thought to contribute to successful dissemination...
  32. pmc Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
    Silvia Polakova
    Department of Cell and Organism Biology, Lund University, SE 22362 Lund, Sweden
    Proc Natl Acad Sci U S A 106:2688-93. 2009
    ..Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability...
  33. ncbi Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient
    Mikkel Krogh-Madsen
    Department of Clinical Microbiology, H S Hvidovre Hospital, Hvidovre, Denmark
    Clin Infect Dis 42:938-44. 2006
    Consecutive Candida glabrata isolates recovered from a patient in an intensive care unit were resistant to amphotericin B (minimum inhibitory concentration, up to 32 mu g/mL; determined by Etest [AB Biodisk])...
  34. ncbi Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata
    Irene Castano
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Mol Microbiol 55:1246-58. 2005
    The pathogenic yeast Candida glabrata is able to bind in vitro to human epithelial cells. This interaction depends on expression of the adhesin Epa1p...
  35. pmc Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants
    Huei Fung Tsai
    Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Antimicrob Agents Chemother 50:1384-92. 2006
    b>Candida glabrata, a yeast with intrinsically low susceptibility to azoles, frequently develops increased azole resistance during prolonged treatment...
  36. ncbi The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, Japan
    FEMS Yeast Res 11:449-56. 2011
    In the pathogenic fungus Candida glabrata, the YPS1 gene, which encodes a glycosylphosphatidylinositol-linked aspartyl protease, is required for cell wall integrity and virulence...
  37. ncbi Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence
    Ana Maria Calcagno
    Department of Infectious Diseases, Imperial College London, Du Cane Road, London W12 ONN, UK
    Yeast 21:557-68. 2004
    ..We have cloned the STE20 homologue from the fungal pathogen Candida glabrata and have shown that it is present in a single copy in the genome...
  38. pmc Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis
    Vishnu Chaturvedi
    Mycology Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA
    Antimicrob Agents Chemother 55:1543-8. 2011
    ..043, C. albicans 20464.007, Candida glabrata 20205.075, and C. parapsilosis 20580.070...
  39. pmc Multilocus microsatellite markers for molecular typing of Candida glabrata: application to analysis of genetic relationships between bloodstream and digestive system isolates
    A Enache-Angoulvant
    AP HP, Hopital Bicetre, Service de Bactériologie Virologie Hygiène, Laboratoire de Parasitologie Mycologie, Kremlin Bicetre, France
    J Clin Microbiol 48:4028-34. 2010
    b>Candida glabrata has emerged as the second most common etiologic agent, after Candida albicans, of superficial and invasive candidiasis in adults...
  40. ncbi Proteogenomic analysis of Candida glabrata using high resolution mass spectrometry
    T S Keshava Prasad
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India
    J Proteome Res 11:247-60. 2012
    b>Candida glabrata is a common opportunistic human pathogen leading to significant mortality in immunosuppressed and immunodeficient individuals. We carried out proteomic analysis of C...
  41. ncbi Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene
    David Stead
    COGEME Proteomics Research Facility 1, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK
    Proteomics 5:1838-48. 2005
    Inactivation of the gene encoding the transcriptional activator Ace2 in the fungal pathogen Candida glabrata results in an almost 200-fold increase in virulence characterised by acute mortality and a massive over-stimulation of the pro-..
  42. ncbi Molecular mechanisms of resistance to 5-fluorocytosine in laboratory mutants of Candida glabrata
    Patrick Vandeputte
    Groupe d Etude des Interactions Hote Pathogene, UPRES EA 3142, Universite d Angers, Bâtiment Montéclair, Centre Hospitalier Universitaire, 4 rue Larrey, 49933, Angers Cedex 9, France
    Mycopathologia 171:11-21. 2011
    Resistance to 5-fluorocytosine (5-FC) has been poorly investigated in the yeast Candida glabrata. This study was conducted on laboratory mutants obtained by exposure of a wild-type isolate to 5-FC...
  43. pmc Mechanism of increased fluconazole resistance in Candida glabrata during prophylaxis
    John E Bennett
    Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antimicrob Agents Chemother 48:1773-7. 2004
    b>Candida glabrata can become resistant to fluconazole, causing persistent colonization and invasive infection during prolonged exposure to the drug...
  44. pmc Murine model of dextran sulfate sodium-induced colitis reveals Candida glabrata virulence and contribution of β-mannosyltransferases
    Samir Jawhara
    Universite Lille Nord de France, 59000 Lille, France
    J Biol Chem 287:11313-24. 2012
    b>Candida glabrata, like Candida albicans, is an opportunistic yeast pathogen that has adapted to colonize all segments of the human gastrointestinal tract and vagina. The C...
  45. pmc New insights into the structure of (1→3,1→6)-β-D-glucan side chains in the Candida glabrata cell wall
    Douglas W Lowman
    Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
    PLoS ONE 6:e27614. 2011
    ..Herein, we report the first detailed structural characterization of the (1→6)-β-linked side chains of Candida glabrata using high-field NMR...
  46. ncbi Significant differences in the cell-wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity
    Shizuka Takahashi
    Department of Infection and Host Defense, Tohoku Pharmaceutical University, Aoba ku, Sendai, Japan
    FEBS J 279:1844-56. 2012
    ..Interestingly, the NBRC 103857 strain, which involved a large amount of the β-1,2-linked mannose residues, exhibited significant sensitivity to these antifungal drugs...
  47. pmc Dynamic evolution of megasatellites in yeasts
    Thomas Rolland
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Department Genomes and Genetics, Paris, France
    Nucleic Acids Res 38:4731-9. 2010
    Megasatellites are a new family of long tandem repeats, recently discovered in the yeast Candida glabrata. Compared to shorter tandem repeats, such as minisatellites, megasatellite motifs range in size from 135 to more than 300 bp, and ..
  48. ncbi In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions
    Zaw M Thein
    Faculty of Dentistry, The University of Hong Kong, Oral Biosciences, 5 F, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong
    Arch Oral Biol 52:761-7. 2007
    ..However, further work is required to fully elucidate how Candida biofilms persist within the oral milieu under such challenging ecological pressures...
  49. pmc Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata
    M A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 50:1199-203. 2012
    ..of antifungal agents is considered to be the first-line treatment of bloodstream infections (BSI) due to Candida glabrata. Recent reports of BSI due to strains of C...
  50. pmc The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eukaryot Cell 7:1951-64. 2008
    The cell wall of the human pathogen Candida glabrata governs initial host-pathogen interactions that underlie the establishment of fungal infections...
  51. ncbi Silver nanoparticles: influence of stabilizing agent and diameter on antifungal activity against Candida albicans and Candida glabrata biofilms
    D R Monteiro
    Department of Dental Materials and Prosthodontics, Araçatuba Dental School, Universidade Estadual Paulista UNESP, Aracatuba, Sao Paulo, Brazil
    Lett Appl Microbiol 54:383-91. 2012
    The purpose of this work was to evaluate the size-dependent antifungal activity of different silver nanoparticles (SN) colloidal suspensions against Candida albicans and Candida glabrata mature biofilms.
  52. ncbi The Candida glabrata adhesin Epa1p causes adhesion, phagocytosis, and cytokine secretion by innate immune cells
    Duncan M Kuhn
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02139, USA
    FEMS Yeast Res 12:398-414. 2012
    While Candida albicans is the most significant fungal pathogen for humans, Candida glabrata accounts for an increasing number of infections. Little is known about how C...
  53. pmc Tn7-based genome-wide random insertional mutagenesis of Candida glabrata
    Irene Castano
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 13:905-15. 2003
    We describe and characterize a method for insertional mutagenesis of the yeast pathogen Candida glabrata using the bacterial transposon Tn7. Tn7 was used to mutagenize a C. glabrata genomic fosmid library...
  54. ncbi Candida glabrata: an emerging pathogen in Brazilian tertiary care hospitals
    Arnaldo L Colombo
    Division of Infectious Diseases Hospital São Paulo, Escola Paulista de Medicina Universidade Federal de Sao Paulo, Rua Botucatu, 740 S ã o Paulo, Brasil
    Med Mycol 51:38-44. 2013
    b>Candida glabrata is an infrequent cause of candidemia in Brazilian public hospitals. We investigated putative differences in the epidemiology of candidemia in institutions with different sources of funding...
  55. ncbi Identification and differential gene expression of adhesin-like wall proteins in Candida glabrata biofilms
    E A Kraneveld
    Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    Mycopathologia 172:415-27. 2011
    ..initial step in biofilm development and subsequent establishment of fungal infections by the human pathogen Candida glabrata is adherence to a surface...
  56. pmc Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint
    Guillermo Garcia-Effron
    Public Health Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Antimicrob Agents Chemother 53:3690-9. 2009
    Thirteen Candida glabrata strains harboring a range of mutations in hot spot regions of FKS1 and FKS2 were studied. The mutations were linked to an echinocandin reduced susceptibility phenotype...
  57. ncbi Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata
    Pirjo Pärnänen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    J Oral Pathol Med 39:275-8. 2010
    ..E-cadherin (E-Cad) is a 120-kDa adhesive protein found in adherens junctions of the digestive tract epithelium. We tested the ability of two Candida strains to degrade human E-Cad in the Candida virulence factor perspective...
  58. ncbi Candida glabrata tryptophan-based pigment production via the Ehrlich pathway
    Sascha Brunke
    Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, Jena, Germany
    Mol Microbiol 76:25-47. 2010
    ..Here, we have dissected the biosynthetic pathway of a tryptophan-derived pigment of the human pathogen Candida glabrata, identified key genes involved in pigment production and have begun to elucidate the possible biological ..
  59. ncbi Biological consequences of petite mutations in Candida glabrata
    Sophie Brun
    Groupe d Etude des Interactions Hôte Parasite, UPRES EA 3142, Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex, France
    J Antimicrob Chemother 56:307-14. 2005
    To define the pathogenicity of respiration-deficient mutants of Candida glabrata, which present a reduced susceptibility to azoles, that are easily induced in vitro by exposure to these drugs or to ethidium bromide and that may be ..
  60. ncbi Dark brown is the more virulent of the switch phenotypes of Candida glabrata
    Thyagarajan Srikantha
    Department of Biology, The University of Iowa, Iowa City, IA 52242, USA
    Microbiology 154:3309-18. 2008
    b>Candida glabrata undergoes reversible, high-frequency core switching between phenotypes that include dark brown (DB), light brown (LB) and white (Wh). These phenotypes in turn can switch to the irregular wrinkle (IWr) phenotype...
  61. ncbi Shifting patterns in the epidemiology of nosocomial Candida infections
    David R Snydman
    Department of Medicine, Division of Geographic Medicine and Infectious Diseases, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Chest 123:500S-3S. 2003
    ..least partially responsible for the proliferation of treatment-resistant, non-albicans isolates, especially Candida glabrata. Thus, selecting the most appropriate candidates for prophylactic antifungal intervention--ie, those with the ..
  62. ncbi Skn7p is involved in oxidative stress response and virulence of Candida glabrata
    Tomomi Saijo
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mycopathologia 169:81-90. 2010
    b>Candida glabrata is an opportunistic fungal pathogen that causes both superficial and deep-seated mycosis in humans...
  63. ncbi Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence
    Ana Maria Calcagno
    Department of Infectious Diseases, Imperial College London, London, UK
    Med Mycol 43:355-64. 2005
    ..We have cloned the STE11 homologue from the fungal pathogen Candida glabrata. The C...
  64. pmc Relationships between respiration and susceptibility to azole antifungals in Candida glabrata
    Sophie Brun
    Groupe d Etude des Interactions Hôte Parasite, UPRES EA 3142, Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, 49033 Angers Cedex 01, France
    Antimicrob Agents Chemother 47:847-53. 2003
    Over the past two decades, the incidence of infections due to Candida glabrata, a yeast with intrinsic low susceptibility to azole antifungals, has increased markedly...
  65. pmc Mitochondrial DNA heteroplasmy in Candida glabrata after mitochondrial transformation
    Jingwen Zhou
    School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China
    Eukaryot Cell 9:806-14. 2010
    ..In this study, the ATP6 gene on mtDNA of the haploid yeast Candida glabrata (Torulopsis glabrata) was deleted by biolistic transformation of DNA fragments with a recoded ARG8(m) ..
  66. ncbi Fluconazole and itraconazole susceptibility of vaginal yeast isolates from Slovakia
    Monika Sojakova
    1st Department of Obstetrics and Gynecology, Faculty of Medicine, Comenius University, Zochova 7, 811 03 Bratislava, Slovak Republic
    Mycopathologia 157:163-9. 2004
    ..These results support the notion that antifungal agents used to treat vaginitis may be contributing to the drug resistance problem by promoting cross-resistance to a range of clinically used antifungals...
  67. ncbi Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation
    Ana Maria Calcagno
    Department of Infectious Diseases and Microbiology, Imperial College London, Du Cane Road, London, W12 0NN, UK
    Mol Microbiol 50:1309-18. 2003
    ..They are also important mediators of fungal virulence. The Candida glabrata STE12 homologue was cloned...
  68. pmc Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence
    Sélène Ferrari
    Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland
    PLoS Pathog 5:e1000268. 2009
    CgPdr1p is a Candida glabrata Zn(2)-Cys(6) transcription factor involved in the regulation of the ABC-transporter genes CgCDR1, CgCDR2, and CgSNQ2, which are mediators of azole resistance...
  69. pmc Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts
    Donna M MacCallum
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 74:5244-8. 2006
    Mutants of Candida albicans, Candida glabrata, and Saccharomyces cerevisiae with disruptions in the ACE2 gene and C. glabrata and S...
  70. pmc Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility
    Santosh Katiyar
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Antimicrob Agents Chemother 50:2892-4. 2006
    ..albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES...
  71. pmc Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae
    Damian J Krysan
    Division of Pediatric Infectious Disease, Department of Pediatrics and Communicable Diseases, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
    Eukaryot Cell 4:1364-74. 2005
    ..The Candida albicans (SAP9) and Candida glabrata (CgYPS1) homologues of YPS1 complement the phenotypes of the yps1Delta mutant...
  72. pmc Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata
    Simon Wong
    Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland
    Genome Biol 4:R10. 2003
    b>Candida glabrata is a pathogenic yeast of increasing medical concern...
  73. pmc Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections
    Cassandra Moran
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    Am J Infect Control 38:78-80. 2010
    We compared costs, length of stay, and mortality between adults with Candida albicans and Candida glabrata bloodstream infections...
  74. pmc Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates
    Huei Fung Tsai
    Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antimicrob Agents Chemother 54:3308-17. 2010
    DNA microarrays were used to analyze Candida glabrata oropharyngeal isolates from seven hematopoietic stem cell transplant recipients whose isolates developed azole resistance while the recipients received fluconazole prophylaxis...
  75. pmc Development of a highly efficient gene targeting system induced by transient repression of YKU80 expression in Candida glabrata
    Keigo Ueno
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chiba 260 8673, Japan
    Eukaryot Cell 6:1239-47. 2007
    In the pathogenic yeast Candida glabrata, gene targeting to generate knockouts and "knockins" is a potentially powerful method for the analysis of gene function. Its importance increased after the C...
  76. ncbi Proteomic analysis of experimentally induced azole resistance in Candida glabrata
    P David Rogers
    Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center Memphis, TN 38163, USA
    J Antimicrob Chemother 58:434-8. 2006
    ..the present study was to identify changes in the proteome of a laboratory-derived azole-resistant strain of Candida glabrata compared with its susceptible parent strain in an effort to identify proteins that are differentially ..
  77. pmc Phenotypic switching and mating type switching of Candida glabrata at sites of colonization
    Paula J Brockert
    Department of Biological Sciences, The University of Iowa, Iowa City 52242, USA
    Infect Immun 71:7109-18. 2003
    b>Candida glabrata switches spontaneously at high frequency among the following four graded phenotypes discriminated on agar containing 1 mM CuSO(4): white, light brown, dark brown (DB), and very dark brown. C...
  78. ncbi Fungaemia caused by Candida glabrata with reduced susceptibility to fluconazole due to altered gene expression: risk factors, antifungal treatment and outcome
    Mario Tumbarello
    Institute of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Antimicrob Chemother 62:1379-85. 2008
    The role of Candida glabrata in fungaemia is attributed in part to its reduced susceptibility to azoles, usually due to altered expression of genes encoding drug efflux pumps...
  79. pmc Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains
    Mariana Castanheira
    JMI Laboratories, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 54:2655-9. 2010
    ..Furthermore, results from this large, geographically diverse Candida spp. collection demonstrated that fks1 HS1 mutations remain uncommon among isolates with various echinocandin MIC levels...
  80. pmc Multiple-locus variable-number tandem-repeat analysis for rapid typing of Candida glabrata
    Frederic Grenouillet
    Mycology Parasitology Department, CHU Jean Minjoz, 25030, Besancon, France
    J Clin Microbiol 45:3781-4. 2007
    ..variable-number tandem-repeat analysis (MLVA) using six microsatellite markers was assessed in 127 Candida glabrata isolates. Thirty-seven different genotypes, stable both in vitro and in vivo, were observed...
  81. ncbi Early prediction of Candida glabrata fungemia in nonneutropenic critically ill patients
    Yves Cohen
    Hopital Avicenne, Service de Reanimation, Bobigny, France
    Crit Care Med 38:826-30. 2010
    Candida species represent the fourth cause of nosocomial bloodstream infections worldwide. Because Candida glabrata has become the second most frequently identified yeast and because the rate of fluconazole-resistant C...
  82. ncbi Function of Candida glabrata ABC transporter gene, PDH1
    Koichi Izumikawa
    Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Yeast 20:249-61. 2003
    The rapid increase in azole resistance during treatment of patients infected with Candida glabrata may be due to increased azole efflux mediated by ABC transporters, as occurs with increased expression of PDR5 in Saccharomyces cerevisiae...
  83. ncbi Candida glabrata: an emerging oral opportunistic pathogen
    L Li
    Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030 1710, USA
    J Dent Res 86:204-15. 2007
    ..Further investigations on the virulence and host-pathogen interactions of C. glabrata are needed to better define the pathogenesis of oral C. glabrata infection in susceptible hosts...
  84. ncbi Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes
    Brunella Posteraro
    Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy, and Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Antimicrob Chemother 58:458-61. 2006
    ..This is of special concern for Candida glabrata infections that are often resistant to many azole antifungal agents and, consequently, difficult to treat...
  85. pmc Evaluation of the Etest and disk diffusion methods for determining susceptibilities of 235 bloodstream isolates of Candida glabrata to fluconazole and voriconazole
    M A Pfaller
    Department of Pathology Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:1875-80. 2003
    The performances of the Etest and the disk diffusion methods for testing of the susceptibilities of 235 Candida glabrata isolates to fluconazole and voriconazole were compared with that of the National Committee for Clinical Laboratory ..
  86. ncbi [A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation]
    Sachiko Inui
    Department of Clinical Laboratory, Kansai Medical University Hirakata Hospital
    Kansenshogaku Zasshi 85:49-53. 2011
    b>Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura...
  87. pmc Inner kinetochore of the pathogenic yeast Candida glabrata
    Tanja Stoyan
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Eukaryot Cell 3:1154-63. 2004
    The human pathogenic yeast Candida glabrata is the second most common Candida pathogen after Candida albicans, causing both bloodstream and mucosal infections. The centromere (CEN) DNA of C...
  88. ncbi [Molecular mechanisms of fluconazole resistance in clinical isolates of Candida glabrata]
    Yin Zhong Shen
    Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 201508, China
    Zhonghua Nei Ke Za Zhi 49:245-9. 2010
    To determine if changes in the levels of expression of ERG11, CDR1 and CDR2 genes could be associated with resistance phenotype in clinical isolates of Candida glabrata (C. glabrata).
  89. ncbi Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro
    Mark R Harris
    Biomedical Sciences Research Complex, School of Biology, University of St Andrews, The North Haugh, St Andrews KY16 9ST, UK
    Int J Antimicrob Agents 35:347-56. 2010
    ..Further study using alternative peptides will identify whether this combination approach could represent a novel treatment for fungal pathogens...
  90. ncbi Invasive Candida infections: the changing epidemiology
    Kieren A Marr
    University of Washington, School of Medicine, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Oncology (Williston Park) 18:9-14. 2004
    ..While Candida albicans remains the most common pathogen, non-albicans Candida species, including Candida glabrata and Candida krusei, with greater resistance to triazoles are being increasingly isolated...
  91. ncbi Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium
    Sonia Silva
    Institute for Biotechnology and Bioengineering, Universidade do Minho, Campus de Gualtar 4710 057, Braga, Portugal
    J Oral Pathol Med 40:421-7. 2011
    Candida albicans is regarded as the leading of candidosis. However, Candida glabrata has emerged as an important pathogen of oral mucosa, occurring both singly or in mixed species infections, often with C. albicans. Compared with C...
  92. pmc Clinical significance of azole antifungal drug cross-resistance in Candida glabrata
    Anil A Panackal
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, 1100 Fairview Ave, D3 100, Seattle, WA 98109, USA
    J Clin Microbiol 44:1740-3. 2006
    b>Candida glabrata, which can become resistant to fluconazole, is a common cause of bloodstream infection. This study was performed to determine the significance of cross-resistance to new azole drugs among C...
  93. ncbi Differences in patient risk factors and source of candidaemia caused by Candida albicans and Candida glabrata
    Madhuri Segireddy
    Division of Infectious Diseases, St John Hospital and Medical Center, Detroit, MI, USA
    Mycoses 54:e39-43. 2011
    There is an increasing frequency of candidaemia caused by Candida glabrata which has decreased in vitro susceptibility to fluconazole. Differences in risk factors for candidaemia caused by C. glabrata and C...
  94. pmc Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient
    Florence Chapeland-Leclerc
    EA 209 Eucaryotes Pathogènes Transports Membranaires et Chimiorésistance, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 54:1360-2. 2010
    We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C...
  95. pmc Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth
    Patrick Vandeputte
    Groupe d Etude des Interactions Hote Pathogene, UPRES EA 3142, Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, Angers Cedex 9, France
    Antimicrob Agents Chemother 53:3034-41. 2009
    ..We describe a clinical isolate of Candida glabrata with a striking association between increased susceptibility to azoles and respiratory deficiency...
  96. ncbi Molecular analysis of Candida glabrata clinical isolates
    Norbert Berila
    Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynska dolina B 2, 842 15, Bratislava 4, Slovak Republic
    Mycopathologia 170:99-105. 2010
    b>Candida glabrata is an important human pathogen, and an understanding of the genetic relatedness of its clinical isolates is essential for the prevention and control of fungal infections...
  97. ncbi Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection
    Michael J Klevay
    Department of Medicine, University of Iowa, Iowa City, 52242, USA
    Diagn Microbiol Infect Dis 64:152-7. 2009
    b>Candida glabrata is a common cause of bloodstream infection (BSI) and exhibits decreased susceptibility to fluconazole. We sought to determine whether patients with C...
  98. pmc Mutational analysis of flucytosine resistance in Candida glabrata
    Thomas D Edlind
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Antimicrob Agents Chemother 54:4733-8. 2010
    ..One such organism is Candida glabrata, which has emerged as the second most common agent of bloodstream and mucosal candidiasis...
  99. pmc Expression of Candida glabrata adhesins after exposure to chemical preservatives
    Renee Domergue Mundy
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Infect Dis 199:1891-8. 2009
    Adherence of Candida glabrata, an opportunistic yeast pathogen, to host cells is mediated in part by the Epa family of adhesins, which are encoded largely at subtelomeric loci, where they are subject to transcriptional silencing...
  100. ncbi Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica
    Zhizhi Du
    The State Key Laboratory of Phytochemistry and Plant Resources in West China, P R China
    Planta Med 69:547-51. 2003
    ..B and ordinary activities (MIA approximately 10 micrograms/disc) against Penicillium avellaneum UC-4376, Candida glabrata, Trichosporon beigelii and Pyricularia oryzae...
  101. pmc High-affinity transporters for NAD+ precursors in Candida glabrata are regulated by Hst1 and induced in response to niacin limitation
    Biao Ma
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Mol Cell Biol 29:4067-79. 2009
    The yeast Candida glabrata is an opportunistic pathogen of humans. C. glabrata is a NAD(+) auxotroph, and its growth depends on the availability of niacin (environmental vitamin precursors of NAD(+))...

Research Grants46

  1. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..Phase I research and development will focus on the detection and differentiation of Candida albicans and Candida glabrata, two of the most common strains of Candida...
  2. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2013
    ..glabrata. PUBLIC HEALTH RELEVANCE: The ability of Candida glabrata, an important yeast pathogen, to cause disease is not well understood...
  3. Identifying novel small molecules for improved antifungal drug treatment
    Martha L Bulyk; Fiscal Year: 2012
    ..antifungal drug resistance in Saccharomyces cerevisiae as well as the pathogenic species Candida albicans and Candida glabrata. Libraries of diverse compounds will be screened by small molecule microarrays (SMMs) to identify those ..
  4. Identification of broad-spectrum antifungal efflux pump inhibitors
    Richard Cannon; Fiscal Year: 2009
    ..of yeast strains expressing efflux pumps from the following clinically relevant fungi: Candida albicans, Candida glabrata, Candida krusei and Cryptococcus neoformans...
  5. Role of transcriptional regulation in Aspergillus fumigatus drug resistance
    W Scott Moye-Rowley; Fiscal Year: 2012
    ..Previous work in fungal pathogens such as Candida albicans and Candida glabrata has provided clear implication of gene transcription as a key determinant of drug resistance...
  6. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Scott Moye-Rowley; Fiscal Year: 2013
    ..cerevisiae) that efflux drugs out of the cell. The pathogenic Candida species, Candida albicans and Candida glabrata, express homologues of ScPdr5 and can acquire similar multidrug resistant phenotypes...
  7. Virulence Mechanisms in Candida Glabrata
    Carlos A Gomez; Fiscal Year: 2010
    ....
  8. Genome-wide investigations in fungal pathogens utilizing an invertebrate model ho
    Eleftherios Mylonakis; Fiscal Year: 2010
    ..Implement whole animal C. elegans assays to identify virulence traits associated with Candida albicans and Candida glabrata infection. Based on our previous C. elegans assays, including C...
  9. Echinocandin Reduced/Increased Susceptibility: Mechanism
    Santosh Kumar Katiyar; Fiscal Year: 2013
    ..In parallel, Candida glabrata has emerged as an important pathogen, largely because it is refractory to treatment with widely used azole ..
  10. Targeting DHFR to Design Antimicrobial Agents
    Amy C Anderson; Fiscal Year: 2012
    Fungal infections have become a significant and increasing cause of severe illness and death. Candida glabrata is emerging as a lethal fungal pathogen, contributing significantly to the mortality already caused by the prevalent pathogen, ..
  11. AIDS Opportunistic Pathogens: Targeting the Methyl Citrate Cycle
    BRENDAN PATRICK CORMACK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Candida glabrata is an important opportunistic pathogen in HIV seropositive and HIV seronegative populations. In the United States, most clinical series over the last 15 years show that C...
  12. ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
    Tadeusz F Molinski; Fiscal Year: 2010
    ..strains of Candida albicans and inherently fluconazole-resistant non-albicans species, including Candida glabrata and Candida krusei and use these as prototype leads for antifungal drugs...
  13. CENTROMERE STRUCTURE AND FUNCTION
    John Carbon; Fiscal Year: 2007
    ..in the two most common and clinically significant pathogenic budding yeasts, Candida albicans and Candida glabrata. All budding yeast species examined to date contain relatively small point centromeres (CEN less than 400 bp ..
  14. SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATA
    David Soll; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The emergence of Candida glabrata as a major commensal in the oral cavity of the elderly, and as the second most common yeast blood stream infection is a matter of dire concern...
  15. Candida Glabrata Gene Activation During Mucosal Infection
    Caroline Westwater; Fiscal Year: 2010
    ..responsible for the largest number of fungal infections, with the majority attributed to Candida albicans and Candida glabrata. Both pathogens produce a similar array of superficial mucosal and life-threatening systemic infections;..
  16. Chromatin-based regulation of multidrug resistance genes
    Karl Henry; Fiscal Year: 2006
    ..Lastly, I will delete genes that encode histone modifying enzymes in the opportunistic pathogen Candida glabrata to determine if these regulatory systems also control drug susceptibility and MDR gene expression...
  17. Role of the OPI1 gene in controlling viability of Candida glabrata
    TODD REYNOLDS; Fiscal Year: 2008
    ..For example, Candida glabrata was isolated from HIV positive patients with denture stomatitis nearly as often as C. albicans (41.3% and 48...
  18. Oral Yeast Carriage and Salivary Antifungal Activity
    EVA HELMERHORST; Fiscal Year: 2008
    ..The experiments outlined here will provide the basis for a better understanding of antifungal mechanisms exerted by saliva in the oral cavity. [unreadable] [unreadable] [unreadable]..
  19. AIDS Opportunistic Pathogens/Fungal Cell Wall Drug Targets
    Brendan Cormack; Fiscal Year: 2006
    ..antifungal agents are available for treatment and to compound the problem, some species of Candida, notably Candida glabrata, are innately resistant to the important triazole class of antifungals...
  20. Mutational Analysis of Fks1: Intrinsic Echinocandin Resistance
    Thomas D Edlind; Fiscal Year: 2010
    ..These studies will accelerate the development of second generation ECs that provide a broader spectrum of protection from fungal pathogens. ..
  21. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..albicans yeast and hyphal forms. MDR gene fragments will be amplified from Candida glabrata, Aspergillus fumigatus, and Cryptococcus neoformans and used as probes for MDR induction studies in those ..
  22. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2005
    ..Finally, the signalling pathway responsible for azole-dependent upregulation of ERG expression will be elucidated with a focus on Rox1p and Haplp transcription factors. ..
  23. Prevention/diagnosis/fungal infections/transplantation
    Barbara Alexander; Fiscal Year: 2005
    ..This approach will shorten the time from development to clinical implementation in therapeutic trials and guidelines. ..
  24. Transplant Associated Infection Surveillance Network
    Peter Pappas; Fiscal Year: 2008
    ..Finally, the establishment of a bank will be invaluable in the development and validation of newer diagnostic assays. ..
  25. Oral and Vaginal Gene Expression by Candida During AIDS
    CORNELIUS CLANCY; Fiscal Year: 2004
    ..abstract_text> ..
  26. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  27. ANALYSIS OF TELOMERASE REVERSE TRANSCRIPTASE
    Neal F Lue; Fiscal Year: 2010
    ....
  28. Molecular Diagnosis of pathogenic fungi
    Robert Akins; Fiscal Year: 2007
    ..We expect that the protocols and strategies developed here for fungi will extend to other, non-culturable organisms. ..
  29. Elucidating the origins and functions of unknown genes
    Howard Ochman; Fiscal Year: 2009
    ..By combining experimental and bioinformatic approaches, the present proposal will analyze the origins, functions and structural properties of ORFans, and how they have assumed key roles in cellular function. ..
  30. Pharmacogenomics/natural products + antifungal activity
    John Cleary; Fiscal Year: 2004
    ..Probing this array with eukaryotic mRNA from cells exposed to novel antifungals would predict common mechanism of action and likelihood of toxicity, activity and resistance. ..
  31. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2004
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  32. Cryptococcus gatti mating 1oci; mapping and gene study
    Vishnu Chaturvedi; Fiscal Year: 2004
    ..abstract_text> ..
  33. Receptor Affects Fungal Mucosal Colonization in HIV
    Mary Ann Jabra Rizk; Fiscal Year: 2005
    ..dubliniensis to be preferentially selected. ..
  34. High Purity Amphotericin B: A Safer Antimycotic in AIDS
    John Cleary; Fiscal Year: 2005
    ..abstract_text> ..
  35. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  36. Probiotic Microbes "The Scientific Basis"
    Carol Wells; Fiscal Year: 2005
    ....
  37. Syndecan and Bacterial Translocation in Shock and Trauma
    Carol Wells; Fiscal Year: 2006
    ..faecalis and S. aureus. ..
  38. Aspergillus Angioinvasion and Dissemination
    Scott Filler; Fiscal Year: 2006
    ..These studies are designed to lay the essential foundation for a comprehensive research program aimed at elucidating the molecular mechanisms by which A. fumigatus invades blood vessels and hematogenously disseminates. ..
  39. MOLECULAR BASIS OF VIRULENCE FACTORS OF ORAL FUNGAL SP.
    Mary Ann Jabra Rizk; Fiscal Year: 2006
    ..Long range plans include using the mutants generated to study Candida mannoprotein-specific host immunomodulation, such as stimulation of cytokines and chemokines. ..
  40. Genome Erosion in Infectious Microorganisms
    Howard Ochman; Fiscal Year: 2007
    ..abstract_text> ..
  41. CANDIDA PATHOGENESIS IN SURGERY AND TRAUMA
    Carol Wells; Fiscal Year: 2007
    ..Such knowledge should accelerate our ability to diagnose, treat, and control systemic candidiasis. ..
  42. THE YEAST ERGOSTEROL PATHWAY
    Martin Bard; Fiscal Year: 2007
    ..Finally, we will complete our analysis of the ERG9 promoter which encodes the squalene synthase, the first enzyme in the mevalonate-sterol pathway dedicated to sterol synthesis. [unreadable] [unreadable]..
  43. Role of Oxidative Mechanisms in the Toxicity of Metals
    SIMON AVERY; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  44. Telomerase function and regulation in a new model system
    Neal Lue; Fiscal Year: 2007
    ..We anticipate that our findings will contribute to a detailed molecular understanding of telomerase function and regulation. ..
  45. PHOSPHOLIPASE B: A VIRULENCE FACTOR FOR CANDIDA GLABRATA
    CORNELIUS CLANCY; Fiscal Year: 2002
    ..long-term research interest is in identifying and studying virulence factors for the yeast pathogen Candida glabrata, now a leading bloodstream fungal infection in the United States. C...
  46. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..