cimicifuga

Summary

Summary: A plant genus of the family RANUNCULACEAE that contains triterpenoid saponins. Remifemin from C. racemosa is used to suppress LUTEINIZING HORMONE. It is reclassified by some to ACTAEA. The common name of black snakeroot is also used with ASARUM and SANICULA.

Top Publications

  1. ncbi Muscle damage induced by black cohosh (Cimicifuga racemosa)
    P L Minciullo
    Department of Human Pathology, Division and School of Allergy and Clinical Immunology, University of Messina, Italy
    Phytomedicine 13:115-8. 2006
  2. ncbi Black cohosh does not exert an estrogenic effect on the breast
    Rachel L Ruhlen
    Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
    Nutr Cancer 59:269-77. 2007
  3. ncbi Dichloromethane fraction of Cimicifuga heracleifolia decreases the level of melanin synthesis by activating the ERK or AKT signaling pathway in B16F10 cells
    Ji Yeon Jang
    Department of Oriental Medicine, College of Oriental Medicine, Dongeui University, Busan, South Korea
    Exp Dermatol 18:232-7. 2009
  4. ncbi Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway
    Zhong Ze Fang
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    Phytother Res 25:17-24. 2011
  5. ncbi Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1
    Barbara A Pockaj
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 24:2836-41. 2006
  6. ncbi First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055
    Karel Raus
    Department of Obstetrics and Gynecology, Charles University Teaching Hospital, Prague, Czech Republic
    Menopause 13:678-91. 2006
  7. ncbi Estrogen-like effect of a Cimicifuga racemosa extract sub-fraction as assessed by in vivo, ex vivo and in vitro assays
    P Bolle
    Department of Human Physiology and Pharmacology, University La Sapienza Ple Aldo Moro, 5 00185 Rome, Italy
    J Steroid Biochem Mol Biol 107:262-9. 2007
  8. ncbi Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study
    Wolfgang Wuttke
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynaecology, University of Gottingen, Germany
    Menopause 13:185-96. 2006
  9. ncbi Three cycloartane glycosides from Cimicifuga rhizome and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction
    Makiko Nishida
    Faculty of Engineering, Kyushu Kyoritsu University, Kitakyushu, Japan
    Chem Pharm Bull (Tokyo) 51:354-6. 2003
  10. ncbi Immunosuppressive effects of new cyclolanostane triterpene diglycosides from the aerial part of Cimicifuga foetida
    Rui Le Pan
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Arch Pharm Res 32:185-90. 2009

Research Grants

Detail Information

Publications169 found, 100 shown here

  1. ncbi Muscle damage induced by black cohosh (Cimicifuga racemosa)
    P L Minciullo
    Department of Human Pathology, Division and School of Allergy and Clinical Immunology, University of Messina, Italy
    Phytomedicine 13:115-8. 2006
    Extracts of black cohosh (Cimicifuga racemosa) are commonly used for the treatment of symptoms associated with menopause. Adverse events with black cohosh are rare, mild and reversible...
  2. ncbi Black cohosh does not exert an estrogenic effect on the breast
    Rachel L Ruhlen
    Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
    Nutr Cancer 59:269-77. 2007
    ..Triterpene content in commercially available black cohosh preparations varies. BCE standardized to 2.5% triterpenes relieved menopausal symptoms without systemic or breast-specific estrogenic effects...
  3. ncbi Dichloromethane fraction of Cimicifuga heracleifolia decreases the level of melanin synthesis by activating the ERK or AKT signaling pathway in B16F10 cells
    Ji Yeon Jang
    Department of Oriental Medicine, College of Oriental Medicine, Dongeui University, Busan, South Korea
    Exp Dermatol 18:232-7. 2009
    b>Cimicifuga rhizoma has long been used in traditional Korean medicine...
  4. ncbi Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway
    Zhong Ze Fang
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    Phytother Res 25:17-24. 2011
    ..study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including ..
  5. ncbi Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1
    Barbara A Pockaj
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 24:2836-41. 2006
    ..Hot flashes can cause significant morbidity in postmenopausal women undergoing or finished with breast cancer treatment. Black cohosh has been used to treat hot flashes, but definitive clinical data about efficacy have been equivocal...
  6. ncbi First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055
    Karel Raus
    Department of Obstetrics and Gynecology, Charles University Teaching Hospital, Prague, Czech Republic
    Menopause 13:678-91. 2006
    To investigate endometrial safety by assessment of endometrial biopsy samples and the tolerability and efficacy of the special Actaea or Cimicifuga racemosa extract (CR BNO 1055).
  7. ncbi Estrogen-like effect of a Cimicifuga racemosa extract sub-fraction as assessed by in vivo, ex vivo and in vitro assays
    P Bolle
    Department of Human Physiology and Pharmacology, University La Sapienza Ple Aldo Moro, 5 00185 Rome, Italy
    J Steroid Biochem Mol Biol 107:262-9. 2007
    Black cohosh (Cimicifuga racemosa) is used in the treatment of painful menstruation and menopausal symptoms...
  8. ncbi Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study
    Wolfgang Wuttke
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynaecology, University of Gottingen, Germany
    Menopause 13:185-96. 2006
    In this study, the effects of the Cimicifuga racemosa (CR) preparation CR BNO 1055 on markers of bone metabolism, hormones, sex hormone-binding globulin (SHBG), lipometabolism, vaginal maturity, and routine laboratory parameters were ..
  9. ncbi Three cycloartane glycosides from Cimicifuga rhizome and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction
    Makiko Nishida
    Faculty of Engineering, Kyushu Kyoritsu University, Kitakyushu, Japan
    Chem Pharm Bull (Tokyo) 51:354-6. 2003
    ..3), were isolated from a commercial Cimicifuga Rhizome...
  10. ncbi Immunosuppressive effects of new cyclolanostane triterpene diglycosides from the aerial part of Cimicifuga foetida
    Rui Le Pan
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Arch Pharm Res 32:185-90. 2009
    ..cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae)...
  11. ncbi A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health
    H Xu
    UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, Chicago, Illinois, USA
    Phytomedicine 9:757-62. 2002
    ..The test materials included samples from three species each of the genera Cimicifuga (Actaea) and Trifolium, as well as samples of Vitex agnus-castus L., Glycyrrhiza glabra L., Gingko biloba L...
  12. ncbi Evaluation of the antiosteoporotic potential of Cimicifuga heracleifolia in female mice
    Byung Su Ahn
    College of Veterinary Medicine, Chonnam National University, Gwangju, 500 757, South Korea
    Phytother Res 26:663-8. 2012
    Cimicifugae rhizoma might be protective against osteoporosis. This study investigated the effects of Cimicifuga heracleifolia (CH), an Asian species of Cimicifugae rhizome, on bone loss in ovariectomized (OVX) mice...
  13. pmc Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma
    Ze Tian
    Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Cancer 7:237. 2007
    ..Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines...
  14. ncbi Cutaneous pseudolymphoma induced by Cimicifuga racemosa
    S Meyer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 214:94-6. 2007
    ..had been taking Remifemin(R), a phytotherapeutical agent containing a standardized extract of black cohosh (Cimicifuga racemosa) rhizome for 1 year...
  15. ncbi In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh)
    Benjamin M Johnson
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 16:838-46. 2003
    Botanical dietary supplements containing Cimicifuga racemosa (Actaea racemosa; black cohosh) are used commonly by women to assuage menopausal symptoms including hot flashes and sleep disorders...
  16. ncbi Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages
    Cindy L H Yang
    Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
    J Med Chem 52:6707-15. 2009
    b>Cimicifuga species have been used as traditional medicinal herbs to treat inflammation and symptoms associated with menopause in Asia, Europe, and North America...
  17. pmc Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7
    Friedemann Gaube
    Institute of Pharmacy, Department of Pharmaceutical Biology, University of Jena, Semmelweisstr, 10, 07743 Jena, Germany
    BMC Pharmacol 7:11. 2007
    Extracts from the rhizome of Cimicifuga racemosa (black cohosh) are increasingly popular as herbal alternative to hormone replacement therapy (HRT) for the alleviation of postmenopausal disorders...
  18. ncbi Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms
    Gail B Mahady
    Department of Pharmacy Practice, UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, Illinois 60612, USA
    Treat Endocrinol 4:177-84. 2005
    ..Black cohosh (Actaea racemosa, syn. Cimicifuga racemosa) is one such alternative that has been used in the US for over 100 years...
  19. ncbi Hepatic effects of Cimicifuga racemosa extract in vivo and in vitro
    S Lude
    Division of Clinical Pharmacology and Toxicology and Department of Research, University Hospital Basel, CH 4031 Basel, Switzerland
    Cell Mol Life Sci 64:2848-57. 2007
    Extracts of Cimicifuga racemosa are used frequently for menopausal complaints. Cimicifuga is well tolerated but can occasionally cause liver injury. To assess hepatotoxicity of cimicifuga in more detail, ethanolic C...
  20. ncbi Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients
    Rishma Walji
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    Support Care Cancer 15:913-21. 2007
    ..This paper will present the results of a systematic review of the safety and efficacy of black cohosh (Cimicifuga racemosa [L.] Nutt.) in patients with cancer.
  21. ncbi Black cohosh and St. John's wort for climacteric complaints: a randomized trial
    Ralf Uebelhack
    Clinic of Psychiatry, Clinic of Gynecology and St Gertrauden Krankenhaus, University Hospital Charité of the Humboldt University, Berlin, Germany
    Obstet Gynecol 107:247-55. 2006
    To investigate the efficacy of the fixed combination of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) extracts in women with climacteric complaints with a pronounced psychological component.
  22. ncbi Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP
    Hubertus Jarry
    Division of Clinical and Experimental Endocrinology, University of Gottingen, Gottingen, Germany
    Planta Med 73:184-7. 2007
    Extracts of Cimicifuga racemosa (L.) Nutt. (syn.: Actaea racemosa L.) (CR) inhibit the proliferation of the human prostate cancer cell line LNCaP...
  23. ncbi The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa)
    Alyson Huntley
    Universities of Exeter and Plymouth, Complementary Medicine, Peninsula Medical School, 25 Victoria Park Road, Exeter, EX2 4NT, UK
    Expert Opin Drug Saf 3:615-23. 2004
    Black cohosh (Actaea racemosa/Cimicifuga racemosa) is a North American perennial plant that has been used for traditional medicinal purposes by the native Indian population...
  24. ncbi Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy
    V Beck
    Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    J Steroid Biochem Mol Biol 84:259-68. 2003
    Extracts from red clover (Trifolium pratense), soybean (Glycine max.) and black cohosh (Cimicifuga racemosa) are frequently used as alternative compounds for hormone replacement therapy (HRT) to treat menopausal disorders...
  25. ncbi Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis
    K Hostanska
    Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Breast Cancer Res Treat 84:151-60. 2004
    Hormone replacement therapy is contraindicated in women with breast cancer. Extracts from the rhizomes of Cimicifuga racemosa, have gained acceptance as a natural alternative for the treatment of menopausal symptoms...
  26. ncbi Black cohosh: just another phytoestrogen?
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Trends Endocrinol Metab 16:214-21. 2005
    ..Furthermore, several studies suggest that A. racemosa extracts might help control psychic problems typically found during menopausal transition...
  27. ncbi Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells
    Linda Saxe Einbond
    Herbert Irvign Comperhensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Breast Cancer Res Treat 83:221-31. 2004
    ..Further studies are in progress to identify the mechanisms by which actein and related compounds present in black cohosh inhibit growth of human breast cancer cells...
  28. ncbi Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages
    Diethart Schmid
    Institute for Physiology, Section of Vegetative Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Austria
    J Pharm Pharmacol 61:1089-96. 2009
    b>Cimicifuga racemosa (Actaea racemosa, black cohosh) is used as an anti-inflammatory, antipyretic and analgesic remedy in traditional medicines. The present study focuses on the effects of C...
  29. ncbi Inhibition of mast cell-dependent allergy reaction by extract of black cohosh (Cimicifuga racemosa)
    Chang Deok Kim
    Oriental Hospital, Oriental Medical College of Daejeon University, Daejeon, South Korea
    Immunopharmacol Immunotoxicol 26:299-308. 2004
    Black cohosh (Cimicifuga racemosa) has been used as therapeutics for pain and inflammation in Korean folk medicine...
  30. ncbi Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells
    Katarina Hostanska
    Department of Internal Medicine F GEL 102, University Hospital Zurich, Switzerland
    Biol Pharm Bull 27:1970-5. 2004
    ..In addition, TTG and CAE compounds significantly contributed to its apoptotic effect, CAE being the more potent inhibitor of proliferation and apoptosis inducer...
  31. ncbi Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract
    Johannes Freudenstein
    Schaper and Brümmer GmbH and Co KG, D 38259 Salzgitter, Germany
    Cancer Res 62:3448-52. 2002
    b>Cimicifuga racemosa (CR) is widely used in the treatment of menopausal symptoms. Mechanistic studies suggest that unlike hormone-replacement therapy, CR does not stimulate estrogen-receptor positive breast cancer cells...
  32. ncbi In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex
    Hye Young Kim
    Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea
    J Clin Virol 41:122-8. 2008
    ..A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of severe acute respiratory syndrome (SARS)...
  33. ncbi Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol
    Rossella E Nappi
    Department of Obstetrics and Gynecology, IRCCS S Matteo, University of Pavia, Pavia, Italy
    Gynecol Endocrinol 20:30-5. 2005
    To investigate, in a randomized clinical study, the efficacy of an isopropanolic aqueous extract of Cimicifuga racemosa (CR) on climacteric complaints in comparison with low-dose transdermal estradiol (TTSE2)...
  34. ncbi Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cells
    Cornelia Bodinet
    Research and Development Department, Schaper and Brümmer GmbH and Co KG, Salzgitter, Germany
    Breast Cancer Res Treat 76:1-10. 2002
    ..To determine the influence of one such alternative, black cohosh (Cimicifuga racemosa [CR]), on estrogen-dependent mammary cancers, we conducted an in vitro investigation of the effect of ..
  35. ncbi Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Agric Food Chem 50:7022-8. 2002
    The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action...
  36. pmc Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products
    Kan He
    Department of Research and Development, Naturex Pure World Botanicals, Inc, 375 Huyler Street, South Hackensack, NJ 07606, USA
    J Chromatogr A 1112:241-54. 2006
    ..It is manufactured from roots and rhizomes of Cimicifuga racemosa (Ranunculaceae)...
  37. ncbi Cytotoxicity of three cycloartane triterpenoids from Cimicifuga dahurica
    Ze Tian
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, People s Republic of China
    Cancer Lett 226:65-75. 2005
    ..In addition, inhibition of cdc2 protein expression correlates with mechanism of G(2)/M arrest...
  38. ncbi Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity
    Hilke Winterhoff
    Institute for Pharmacology and Toxicology, Central Clinic, University of Munster, Domagkstrasse 12, 48149 Munster, Germany
    Maturitas 44:S51-8. 2003
    Ethanolic- and isopropanolic-aqueous extracts of Cimicifuga racemosa are used for the treatment of climacteric complaints...
  39. ncbi The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers
    W Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S67-77. 2003
    In the present study, therapeutic effects of the Cimicifuga racemosa preparation CR BNO 1055 (Klimadynon/Menofem) on climacteric complaints, bone metabolism and endometrium will be compared with those of conjugated estrogens (CE) and ..
  40. ncbi Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP
    H Jarry
    Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Phytomedicine 12:178-82. 2005
    Extracts from black cohosh (Cimicifuga racemosa, CR) exert an anti-proliferative action in human breast cancer cell cultures, which has been attributed to an anti-estrogenic effect...
  41. ncbi Black cohosh (Cimicifuga racemosa) for menopausal symptoms: a systematic review of its efficacy
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Pharmacol Res 58:8-14. 2008
    ..These therapies include herbal preparations such as black cohosh (Cimicifuga racemosa)...
  42. ncbi Phenolic esters from the rhizomes of Cimicifuga racemosa do not cause proliferation effects in MCF-7 cells
    Stefan Stromeier
    Institute of Pharmaceutical Biology and Phytochemistry, Westfalische Wilhelms Universitat, Munster, Germany
    Planta Med 71:495-500. 2005
    ..isoferulate (cimiciphenone) were isolated from a commercially available extract of the rhizomes of Cimicifuga racemosa (L.) Nutt. (syn. Actaea racemosa L...
  43. ncbi Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida
    Ze Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100094, PR China
    Fitoterapia 77:39-42. 2006
    Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines...
  44. ncbi Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa
    Daniel S Fabricant
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 68:1266-70. 2005
    ..1), together with the known compound fukinolic acid (2), was isolated from the n-BuOH-soluble fraction of Cimicifuga racemosa roots that showed 5-HT7 receptor binding activity...
  45. ncbi Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Agric Food Chem 51:5661-70. 2003
    Extracts of the rhizome of black cohosh [Actaea racemosa L., formerly called Cimicifuga racemosa (L.) Nutt.] were evaluated for potential mechanisms of action in the alleviation of menopausal hot flashes...
  46. ncbi Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cells
    Linda Saxe Einbond
    Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    Planta Med 72:1200-6. 2006
    ....
  47. ncbi Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus
    D Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S39-50. 2003
    ..Owing to the increased risks of breast cancer and cardiovascular diseases, patients look for alternatives. Cimicifuga racemosa (CR) preparations might be an alternative, because they proved to reduce climacteric complaints as ..
  48. ncbi In vitro effects of the Cimicifuga racemosa extract BNO 1055
    Hubertus Jarry
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S31-8. 2003
    Extracts of Black cohosh (Cimicifuga racemosa or CR) have been used for the treatment of climacteric complaints since decades. Efficacy, particularly concerning neurovegetative and psychic symptoms, has been proven in clinical trials...
  49. ncbi Cimicifuga racemosa: a systematic review of its clinical efficacy
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Eur J Clin Pharmacol 58:235-41. 2002
    b>Cimicifuga racemosa has long been advocated as an alternative to hormone-replacement therapy. However, recent experimental studies and a clinical trial have raised some questions on its utility...
  50. ncbi Effects of an isopropanolic extract of Cimicifuga racemosa on urinary crosslinks and other parameters of bone quality in an ovariectomized rat model of osteoporosis
    Thomas Nisslein
    Schaper and Brümmer, R and D Veterinary Medicine, Bahnhofstr 35, 38259 Salzgitter, Germany
    J Bone Miner Metab 21:370-6. 2003
    ..Because extracts of black cohosh are already recognized as safe and effective in the treatment of certain gynecological disorders, a longer-term clinical trial of this herbal remedy for the treatment of osteoporosis is warranted...
  51. ncbi Two new cyclolanostanol xylosides from the aerial parts of Cimicifuga dahurica
    Yong Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People s Republic of China
    J Nat Prod 65:1486-8. 2002
    From the aerial parts of Cimicifuga dahurica, two new cyclolanostanol xylosides, cimilactone A (1) and cimilactone B (2), and three known compounds were isolated...
  52. ncbi Pharmacological effects of Cimicifuga racemosa
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Life Sci 73:1215-29. 2003
    b>Cimicifuga racemosa is widely employed to relieve menopause symptoms for its hormonal-like action. However, recent experimental studies have not found an estrogenic action by this plant...
  53. pmc Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor
    Mee Ra Rhyu
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research and Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois, Chicago, Illinois 60612, USA
    J Agric Food Chem 54:9852-7. 2006
    ..8 +/- 7.7 microg/mL. These results demonstrate for the first time that black cohosh contains active principle(s) that activate hMOR, supporting its beneficial role in alleviating menopausal symptoms...
  54. ncbi Chemical constituents from Cimicifuga foetida
    Pei Cao
    Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
    J Asian Nat Prod Res 7:145-9. 2005
    From the rhizoma of Cimicifuga foetida L. (Ranunculaceae) a new chromone, 6'-hydroxylangelicain (18), has been isolated together with 20 known compounds...
  55. pmc Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells
    Linda Saxe Einbond
    Department of Rehabilitation Medicine, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, HHSC 1509, 701 W 168th Street, New York, NY 10032, USA
    Phytomedicine 15:504-11. 2008
    ..this report is to explore the growth inhibitory effect of extracts and compounds from black cohosh and related Cimicifuga species on human breast cancer cells and to determine the nature of the active components...
  56. ncbi Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta
    Dana Seidlova-Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Eur J Endocrinol 149:351-62. 2003
    ..In the present experiments, the effects of the clinically used Cimicifuga racemosa (CR) extract BNO 1055 in the uterus, in the bone and on serum luteinizing hormone (LH) were compared ..
  57. ncbi Black cohosh: a cause of abnormal postmenopausal liver function tests
    D Joy
    Locum Consultant Gastroenterologist, Prince Phillip Hospital, Llanelli, Carmarthenshire, UK
    Climacteric 11:84-8. 2008
    ..Black cohosh is commonly used for postmenopausal symptoms. We present two cases of liver toxicity related to this and recommend close monitoring of women on this herbal preparation...
  58. ncbi Alternative treatments of vasomotor symptoms of menopause
    Baoming Ge
    Ann Intern Med 147:346; author reply 347. 2007
  59. ncbi The Herbal Alternatives for Menopause (HALT) Study: background and study design
    Katherine M Newton
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Maturitas 52:134-46. 2005
    ..Despite inherent challenges, the study of alternative therapies for menopause symptoms is a rewarding and important area deserving of further inquiry...
  60. doi [Adverse effects of Cimicifuga]
    J L Schmutz
    Service de Dermatologie, Hopital Fournier, 36, quai de la Bataille, 54035 Nancy Cedex, France
    Ann Dermatol Venereol 135:170. 2008
  61. ncbi Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study
    Susan D Reed
    Group Health Center for Health Studies, Seattle, WA, USA
    Menopause 15:51-8. 2008
    ..To evaluate vaginal, endometrial, and reproductive hormone effects of three herbal regimens compared with placebo and hormone therapy (HT)...
  62. ncbi The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin
    Leslie Spangler
    Center for Health Studies, Group Health, Seattle, WA 98101, USA
    Maturitas 57:195-204. 2007
    ..Little is known about its effect on other physiologic parameters that could result in untoward events. This study examines the effect of black cohosh on lipids, fibrinogen, glucose and insulin...
  63. ncbi Use of alternative and complementary medicine in menopause
    H J Kang
    Division of Reproduction Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA
    Int J Gynaecol Obstet 79:195-207. 2002
    ..To review the clinical evidence available for the treatment of menopausal symptoms with alternative and complementary medicine...
  64. ncbi Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh
    Adam Ingraffea
    J Am Acad Dermatol 56:S124-6. 2007
  65. ncbi Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study
    Carmela Rotem
    Felsenstein Medical Research Center, Beilinson Campus, Petah Tiqva, Israel
    Gynecol Endocrinol 23:117-22. 2007
    ....
  66. ncbi Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial
    Katherine M Newton
    Group Health Center for Health Studies, The University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98101, USA
    Ann Intern Med 145:869-79. 2006
    ..Herbal supplements are widely used for vasomotor symptoms...
  67. pmc Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms
    Da Jung Chung
    Department of Obstetrics and Gynecology, Yonsei University College of Medicine, 134 Sinchon dong, Seodaemun gu, Seoul, Korea
    Yonsei Med J 48:289-94. 2007
    This study was conducted to investigate the efficacy of black cohosh (Cimicifuga racemosa) and St...
  68. ncbi Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
    Curr Med Chem 13:2927-51. 2006
    ....
  69. ncbi [Complementary and alternative therapies for climacteric symptoms]
    Bettina Reinhard-Hennch
    Ambulanz fur Naturheilkunde und Integrative Medizin, Abteilung Gynakologische Endokrinologie und Fertilitatsstorungen, Universitatsklinikum Heidelberg, Heidelberg, Deutschland
    Gynakol Geburtshilfliche Rundsch 46:197-213. 2006
    ..Review on complementary and alternative therapies for climacteric symptoms...
  70. pmc Chlorination diversifies Cimicifuga racemosa triterpene glycosides
    Shao Nong Chen
    UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 70:1016-23. 2007
    Extracts from the roots and rhizomes of black cohosh (Cimicifuga racemosa) are widely used as dietary supplements to alleviate menopausal symptoms...
  71. ncbi Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial
    Mesut Oktem
    Department of Obstetrics and Gynecology, Baskent University, School of Medicine, Maltepe, Ankara, Turkey
    Adv Ther 24:448-61. 2007
    ..Compared with fluoxetine, black cohosh is more effective for treating hot flushes and night sweats. On the other hand, fluoxetine is more effective in improvements shown on Beck's Depression Scale...
  72. ncbi Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone
    Wenpei Bai
    The First Hospital of Peking University, Department of Gynecology, Beijing, China
    Maturitas 58:31-41. 2007
    To investigate the efficacy-safety balance of the isopropanolic extract of Actaea (=Cimicifuga) racemosa (iCR, Remifemin) in comparison with tibolone in Chinese women with climacteric complaints.
  73. ncbi Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review
    Deepti Cheema
    Royal Worcestershire Hospital, Worcester, UK
    Arch Gynecol Obstet 276:463-9. 2007
    ..Interest in non-hormonal therapies for the treatment of menopausal symptoms has increased since the publication of adverse effects of estrogen replacement therapy...
  74. ncbi [Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials]
    Wiesław Maciej Kanadys
    Poradnia Ginekologiczno Połoznicza Przychodni Specjalistycznej NZOZ Specjalistyka Czechów w Lublinie
    Ginekol Pol 79:287-96. 2008
    ..The following paper reviews professional literature about Black Cohosh (Actaea/Cimicifuga racemosa), either used alone or in combination with other medicinal herbs administered in management of ..
  75. ncbi Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial
    S Frei-Kleiner
    Institute of Pharmaceutical Biology, University of Basel, Switzerland
    Maturitas 51:397-404. 2005
    ..To compare the efficacy and safety of the black cohosh root extract Cr 99 with placebo in women with climacteric complaints...
  76. ncbi Treating hot flushes without hormone replacement therapy
    Machelle M Seibel
    University of Massachusetts School of Medicine, Worcester, USA
    J Fam Pract 52:291-6. 2003
  77. ncbi Definitive statements should only be made with evidence
    Bruce Bonde
    Am Fam Physician 70:1448, 1450; author reply 1450-1. 2004
  78. ncbi Clinical inquiries. What nonhormonal therapies are effective for postmenopausal vasomotor symptoms?
    Dan Brewer
    Department of Family Medicine, University of Tennessee Knoxville, USA
    J Fam Pract 52:324-5, 329. 2003
  79. ncbi Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief
    Tieraona Low Dog
    1Integrative Medicine Education Associates, Corrales, NM, and 2Innovative Science Solutions, LLC, Morristown, NJ 87048, USA
    Menopause 10:299-313. 2003
    This comprehensive review examines the safety of Cimicifuga racemosa for the treatment of menopause symptoms, particularly in populations in which conventional menopause treatment regimens, including estrogen replacement, are ..
  80. ncbi [Phytotherapy in menopausal symptoms]
    Rüdiger Osmers
    Fachabteilung Frauenheilkunde, Städt Krankenhaus Hildesheim GmbH
    Pharm Unserer Zeit 33:384-91. 2004
  81. ncbi Influence of marketed herbal menopause preparations on MCF-7 cell proliferation
    Cornelia Bodinet
    Schaper and Brümmer GmbH and Co KG, Research and Development Department, Salzgitter, Germany
    Menopause 11:281-9. 2004
    ....
  82. ncbi Herbal & dietary supplements for hot flashes: here's what works--and what doesn't
    Marcia Phillips
    Rush University College of Health Sciences, IL, Chicago, USA
    AWHONN Lifelines 7:414-20. 2003
  83. ncbi Alternatives to estrogen
    Lorraine A Fitzpatrick
    Endocrine Research Unit, Department of Endocrinology, Diabetes, Metabolism, Nutrition and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Med Clin North Am 87:1091-113, x. 2003
    ..This article reviews the challenges and problems with the use of alternative medicines, and the clinical trials that prove their efficacy, and discusses the safety issues that may occur with these types of products...
  84. ncbi Drug-herb interactions with herbal medicines for menopause
    Alyson Huntley
    Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK
    J Br Menopause Soc 10:162-5. 2004
    ..This article outlines the major known and theoretical drug-herb interactions of herbal medicines thought to be of benefit for menopausal symptoms, as well as discussing the implications for the medical profession...
  85. ncbi Phytoestrogens for hormone replacement therapy?
    W Wuttke
    Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    J Steroid Biochem Mol Biol 83:133-47. 2002
    ..In the urogenital tract, including the vagina, soy and red clover derived isoflavones are without effects. Cimicifuga racemosa extracts are traditionally used for the treatment of climacteric complaints...
  86. ncbi Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer
    Gerardo Hernández Muñoz
    Centro Clínico de Maternidad Leopoldo Aguerrevere, Av Rio Manapire, Parque Humboldt, Prados del Este, Caracas, Venezuela
    Maturitas 44:S59-65. 2003
    To examine the effect of Cimicifuga racemosa (CR BNO 1055) on hot flushes caused by tamoxifen adjuvant therapy in young premenopausal breast cancer survivors. This treatment presents an off-label use of CR BNO 1055.
  87. ncbi Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study
    Marieke O Verhoeven
    Project Ageing Women, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Menopause 12:412-20. 2005
    To investigate the effects of a novel dietary supplement containing soy isoflavones and Actaea racemosa Linnaeus (formerly called Cimicifuga racemosa L.) on climacteric symptoms in healthy perimenopausal women.
  88. ncbi The effects of remifemin on subjective symptoms of menopause
    Gabor Vermes
    2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    Adv Ther 22:148-54. 2005
    ..in subjective symptoms of menopause in 2016 Hungarian women who had been treated with an isopropanol extract of Cimicifuga racemosa (black cohosh). The inclusion criteria were age (40-65 y)...
  89. ncbi Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine
    Briant E Burke
    Research Service, Department of Veterans Affairs Medical Center, Boise, ID 83702, USA
    Biomed Pharmacother 56:283-8. 2002
    ..3 +/- 2.4 (mean +/- s.e.m.) in placebo treated patients to 4.7 +/- 1.8 (P < 0.01) in patients treated with the phytoestrogen preparation...
  90. ncbi Morning/evening menopausal formula relieves menopausal symptoms: a pilot study
    Jidong Sun
    Enzymatic Therapy, Inc, Green Bay, WI 54311, USA
    J Altern Complement Med 9:403-9. 2003
    ....
  91. ncbi [Pharmacologic and clinical studies using Cimicifuga racemosa in climacteric complaints]
    H Winterhoff
    Institut für Pharmakologie und Toxikologie des Universitätsklinikums Münster, Deutschland
    Wien Med Wochenschr 152:360-3. 2002
    ..These complaints are usually treated with estrogens, but extracts of Cimicifuga racemosa are used for this indication, too...
  92. ncbi The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathways
    Marcela Garita-Hernandez
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Cordoba, Spain
    Planta Med 72:317-23. 2006
    Despite the wide use of Cimicifuga racemosa (CR) extract to treat symptoms associated with menopause and other gynecological disorders, very little is known about its mechanism of action...
  93. ncbi Black cohosh: an alternative therapy for menopause?
    Gail B Mahady
    UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois, Chicago, Illinois, USA
    Nutr Clin Care 5:283-9. 2002
    ..One such alternative is black cohosh (Actaea racemosa, syn. Cimicifuga racemosa), which has been used in the United States for the treatment of gynecologic complaints for more than ..
  94. ncbi Botanicals' effect on menopausal symptoms
    Julia Wilson
    Planned Parenthood Federation of America, New York, NY, USA
    Holist Nurs Pract 18:274. 2004
  95. ncbi Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?
    Wolfgang Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S9-20. 2003
    ..from the literature as well as own results of effects of soy, red clover and their isoflavones as well as of the Cimicifuga racemosa extract BNO 1055...
  96. ncbi Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process
    Ken Wojcikowski
    Molecular and Cellular Pathology, School of Medicine, University of Queensland, Brisbane, Queensland, Australia
    J Altern Complement Med 13:103-9. 2007
    ..The prevalence of chronic renal disease exceeds 10% in industrialized societies. Oxidative damage is thought to be one of the main mechanisms involved in nearly all chronic renal pathologies...
  97. ncbi The Cimicifuga racemosa special extract BNO 1055 prevents hot flashes in ovariectomized rats
    Priya Kapur
    Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand, India
    Phytomedicine 17:890-4. 2010
    ..Need therefore arises to search for non-estrogenic alternatives. It is well established that extracts of Cimicifuga racemosa (CR) ease climacteric complaints but solid animal experimental data supporting such effects are not ..
  98. ncbi Development of a fast and convenient method for the isolation of triterpene saponins from Actaea racemosa by high-speed countercurrent chromatography coupled with evaporative light scattering detection
    Serhat Sezai Cicek
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innsbruck, Austria
    Planta Med 76:467-73. 2010
    ..9 mg). Purity of the isolated substances was 96.8 %, 96.2 %, 97.9 %, and 98.4 %, respectively. The same method was suitable for the purification of actein and 23-epi-26-deoxyactein, with purities of 97.0 % and 98.3 %...
  99. ncbi Phytoestrogens in botanical dietary supplements: implications for cancer
    Colleen E Piersen
    UIC NIH Center for Botanical Dietary Supplements Research in the Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois at Chicago, College of Pharmacy, 60612, USA
    Integr Cancer Ther 2:120-38. 2003
    ..The review will focus on 5 popular botanical dietary supplements: Trifolium pratense (red clover), Cimicifuga racemosa (black cohosh), Humulus lupulus (hops), Angelica sinensis (dong quai), and Glycyrrhiza glabra (licorice)..
  100. ncbi Analysis of terpene compounds in Cimicifuga foetida L. by reversed-phase high-performance liquid chromatography with evaporative light scattering detection
    L Kong
    National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 161 Zhongshan Road, Dalian 116011, China
    J Chromatogr A 936:111-8. 2001
    ..Actein, 27-deoxyactein and cimicifugoside in a typical Chinese medicine of Cimicifuga foetida L. were quantitatively analyzed...
  101. ncbi [Herbal medicine in womens' life cycle]
    Eran Ben-Arye
    The Complementary and Traditional Medicine Unit, Department of Family Medicine, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Harefuah 145:738-42, 782. 2006
    ..agnus) in the treatment of PMS, Ginger (Zingiber officinale) in the treatment of hyperemesis gravidarum and (Cimicifuga racemosa) in the treatment of menopausal hot flushes...

Research Grants31

  1. Serotonergic Botanicals for Menopausal Treatment
    SHARLA POWELL; Fiscal Year: 2009
    ..b>Cimicifuga racemosa (Black Cohosh), Angelica sinensis (Dong Quai), and Valerian officinalis (Valerian) have all proven ..
  2. Botanicals for Treatment of Depression
    GREGORY THATCHER; Fiscal Year: 2006
    ..A long term goal of the project, is the development of an in vitro screen for identifying antidepressant botanicals. ..
  3. A NEW CULTIVATION SYSTEM FOR CLEAN CONSISTENT ROOT CROPS
    ANITA HAYDEN; Fiscal Year: 2004
    ..Urtica dioica), purple coneflower (Echinacea purpurea), yerba mansa (Anemopsis califomica), and black cohosh (Cimicifuga racemosa)...
  4. DNA and Phytochemical Fingerprinting of Actaea Species
    Edward Kennelly; Fiscal Year: 2007
    Black cohosh (Actaea racemosa, syn. Cimicifuga racemosa) is a popular dietary supplement and currently one of the most promising alternative approaches to hormone replacement therapy for menopausal women...
  5. Beta-amyloid 1-42 lowering agent for Alzheimer's Disease
    MARK FINDEIS; Fiscal Year: 2006
    ..This compound will be of interest for other neurological disorders where Ap-related toxicity may be a contributing factor. [unreadable] [unreadable]..
  6. Anticancer Potential of Black Cohosh on Breast Cancer
    LINDA EINBOND; Fiscal Year: 2007
    ..Black cohosh, Actaea racemosa L. (= Cimicifuga racemosa), is a North American perennial in the buttercup family (Ranunculaceae) used for various women's ..
  7. Botanicals from Central America for Menopause
    Gail Mahady; Fiscal Year: 2005
    ..Successful validation and standardization of traditional plant-based medicines used to treat menopause has great significance not only for the women of Central America but the rest of the world as well. ..
  8. Botanicals for Chlamydia pneumonia infections-Revision 1
    Gail Mahady; Fiscal Year: 2005
    ..Data and active standardized extracts developed during this work will be used as the basis for future clinical trials. ..
  9. HRT Decision Making in the Post-WHI Era
    Katherine Newton; Fiscal Year: 2006
    ..This study will provide key information about HRT decision making, and experiences with HRT discontinuation, in an era of increased scientific clarity about HRT's risks and benefits. [unreadable] [unreadable]..
  10. Conference on Emerging Research Technologies
    Gail Mahady; Fiscal Year: 2004
    ....
  11. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  12. ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIAL
    Katherine Newton; Fiscal Year: 2004
    ....
  13. EVALUATION OF BOTANICALS FOR H .PYLORI INFECTIONS
    Gail Mahady; Fiscal Year: 2002
    ..pylori strains. Active extracts will be utilized for in vivo studies. The long-term objectives are to develop safe and effective botanical extracts for the treatment and prevention of H. pylori infections. ..
  14. Mechanisms of prostate cancer prevention by lycopene
    Richard van Breemen; Fiscal Year: 2007
    ..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. [unreadable] [unreadable] [unreadable]..
  15. Black cohosh therapy for menopause-related anxiety
    Jay Amsterdam; Fiscal Year: 2006
    ..We hypothesize that Black Cohosh will result in superior QOL measures compared to placebo. ..
  16. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
    ..abstract_text> ..
  17. 2D-HPLC-Tandem Mass Spectrometer for Proteomics
    Richard van Breemen; Fiscal Year: 2005
    ..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
  18. HYPOTHALAMIC AGING AND MENOPAUSE
    Nancy Reame; Fiscal Year: 2001
    ....
  19. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  20. Multidiscipli. GCRC-Mentorship Program in Womens Health
    Lorraine Fitzpatrick; Fiscal Year: 2003
    ..abstract_text> ..
  21. Pharmacogenetic Epidemiology of Birth Defects and Cancer
    Timothy Rebbeck; Fiscal Year: 2004
    ....
  22. VENLAFAXINE FOR HOT FLASHES FOLLOWING BREAST CANCER
    JANET CARPENTER; Fiscal Year: 2003
    ..e., t-tests, linear regression, GEE, mixed model). Study findings will significantly contribute to the scientific basis of hot flash management in women following treatment for breast cancer. ..
  23. Estrogen Receptors and Maintenance of Lens Transparency
    Vicki Davis; Fiscal Year: 2005
    ..This study will provide the gateway for future studies to investigate how exposure to various estrogens influence risk of age-related cataracts and the potential of estrogens as a therapy for cataract prevention. ..
  24. HPLC time-of-flight mass spectrometer for accurate mass measurements
    Richard van Breemen; Fiscal Year: 2007
    ..to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs [unreadable] [unreadable] [unreadable]..
  25. Interactions of Black Cohosh with Cancer Therapy
    Sara Rockwell; Fiscal Year: 2005
    DESCRIPTION (provided by applicant) Black cohosh (Cimicifuga racemosa), is a widely used herbal medicine which is often assumed to be a safe and effective natural remedy for menopausal symptoms in women who have been advised by their ..
  26. The Bioavilaibility of Folate in Humans
    Richard van Breemen; Fiscal Year: 2004
    ..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..
  27. Computerized Assessment of Cancer Symptoms
    JANET CARPENTER; Fiscal Year: 2005
    ....
  28. Effects of Botanicals on Cognition in Midlife Women
    Pauline Maki; Fiscal Year: 2005
    ..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
  29. SPECT Brain Imaging as a Biomarker of Major Depression
    Jay Amsterdam; Fiscal Year: 2007
    ..We will compare these results to measurements of striatal DAT levels in 22 non-depressed, healthy subjects studied under similar conditions with [99mTc]TRODAT-1 SPECT on two separate occasions 8 weeks apart. ..
  30. Chamomile therapy for generalized anxiety disorder
    Jay Amsterdam; Fiscal Year: 2006
    ....