human herpesvirus 1

Summary

Summary: The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.

Top Publications

  1. pmc Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro
    Chris Boutell
    Medical Research Council Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 76:841-50. 2002
  2. ncbi TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
  3. ncbi A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry
    D Shukla
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell 99:13-22. 1999
  4. pmc Roles for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cells
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:5324-32. 2003
  5. pmc MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs
    Jennifer Lin Umbach
    Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 454:780-3. 2008
  6. ncbi Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
    R J Geraghty
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 280:1618-20. 1998
  7. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
  8. pmc Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathway
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    J Virol 79:7609-16. 2005
  9. pmc Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:1315-20. 2004
  10. ncbi Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    A Wald
    Department of Medicine, University of Washington, Seattle 98122, USA
    N Engl J Med 342:844-50. 2000

Detail Information

Publications306 found, 100 shown here

  1. pmc Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro
    Chris Boutell
    Medical Research Council Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 76:841-50. 2002
    ..We conclude that ICP0 has the potential to act as an E3 ubiquitin ligase during viral infection and to target specific cellular proteins for destruction by the 26S proteasome...
  2. ncbi TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
    ..Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3...
  3. ncbi A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry
    D Shukla
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell 99:13-22. 1999
    ....
  4. pmc Roles for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cells
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:5324-32. 2003
    ..The results suggest that HSV can utilize two distinct entry pathways, depending on the type of cell encountered...
  5. pmc MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs
    Jennifer Lin Umbach
    Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 454:780-3. 2008
    ..Thus, HSV-1 expresses at least two primary miRNA precursors in latently infected neurons that may facilitate the establishment and maintenance of viral latency by post-transcriptionally regulating viral gene expression...
  6. ncbi Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
    R J Geraghty
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 280:1618-20. 1998
    ..HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system...
  7. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response...
  8. pmc Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathway
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    J Virol 79:7609-16. 2005
    ..Thus, HSV utilizes fundamentally different cellular entry pathways to infect important target cell populations...
  9. pmc Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:1315-20. 2004
    ..Thus, these studies suggest the TLR2-mediated cytokine response to HSV-1 is detrimental to the host...
  10. ncbi Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    A Wald
    Department of Medicine, University of Washington, Seattle 98122, USA
    N Engl J Med 342:844-50. 2000
    ..Historically, it has been assumed that these persons have less frequent viral reactivation than those with symptomatic infection...
  11. pmc Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid
    P Desai
    Virology Laboratories, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 72:7563-8. 1998
    ....
  12. ncbi Glycoprotein-D-adjuvant vaccine to prevent genital herpes
    Lawrence R Stanberry
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
    N Engl J Med 347:1652-61. 2002
    ..An effective prophylactic vaccine would help control the spread of genital herpes...
  13. ncbi Herpes simplex virus epidemiology and ocular importance
    T J Liesegang
    Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Cornea 20:1-13. 2001
    ..To review the changing epidemiology of herpes simplex disease and correlate it with the epidemiology of ocular herpes simplex disease...
  14. pmc Cellular and viral requirements for rapid endocytic entry of herpes simplex virus
    Anthony V Nicola
    Medical Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    J Virol 78:7508-17. 2004
    ..Thus, similar to entry via direct penetration at the cell surface, HSV entry into cells by wortmannin-sensitive endocytosis is efficient, involves rapid cellular uptake of viral particles, and requires gB, gD, and gH-gL...
  15. ncbi Three-dimensional structure of herpes simplex virus from cryo-electron tomography
    Kay Grünewald
    Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 302:1396-8. 2003
    ..The envelope contained 600 to 750 glycoprotein spikes that varied in length, spacing, and in the angles at which they emerge from the membrane. Their distribution was nonrandom, suggesting functional clustering...
  16. pmc Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response
    Diethilde Theil
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 163:2179-84. 2003
    ..The chronic immune response seems to maintain viral latency and influence viral reactivation...
  17. pmc Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1
    Richard S B Milne
    Department of Microbiology, University of Pennsylvania, School of Dental Medicine, 215 Levy Building, 240 South 40th Street, Philadelphia, PA 19104 6002, USA
    J Virol 79:6655-63. 2005
    ..Resistance to similar reagents should therefore not be taken as proof of HSV entry by a nonendosomal pathway. These data define a novel gD receptor-dependent acid-independent endocytic entry pathway for HSV...
  18. pmc Specific histone tail modification and not DNA methylation is a determinant of herpes simplex virus type 1 latent gene expression
    Nicole J Kubat
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610 0266, USA
    J Virol 78:1139-49. 2004
    ..These data suggest that histone composition may be a major regulatory determinant of HSV latency...
  19. pmc Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus
    B Sodeik
    Yale University School of Medicine, Department of Cell Biology, New Haven, Connecticut 06520 8002, USA
    J Cell Biol 136:1007-21. 1997
    ..We propose that the incoming capsids bind to microtubules and use dynein to propel them from the cell periphery to the nucleus...
  20. pmc Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
    Lawrence T Feldman
    Department of Microbiology and Immunology, University of California Medical Center, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 99:978-83. 2002
    ..In the absence of detectable infectious virus in these ganglia, we propose the term "spontaneous molecular reactivation" to describe this ongoing process...
  21. pmc Determination of interactions between tegument proteins of herpes simplex virus type 1
    Valerio Vittone
    Centre for Virus Research, The Westmead Millennium Institute, Australia
    J Virol 79:9566-71. 2005
    ..Knowledge of HSV-1 tegument protein-protein interactions will provide insights into the pathways of tegument assembly, and the identified interactions are potential targets for new antiviral drugs...
  22. pmc A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells
    Vaibhav Tiwari
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 60612, UK
    J Virol 79:13173-9. 2005
    ..Blocking of entry by anti-herpesvirus entry mediator (HVEM) antibody implicated HVEM as the major receptor for HSV-1 infection...
  23. ncbi Active intranuclear movement of herpesvirus capsids
    Thomas Forest
    Department of Microbiology and Immunology, C5132 Veterinary Education Center, Cornell University, Ithaca, NY 14853 6401, USA
    Nat Cell Biol 7:429-31. 2005
    ....
  24. pmc Detection of Herpes simplex virus DNA by real-time PCR
    H H Kessler
    Institute of Hygiene, Karl Franzens University Graz, A 8010 Graz, Austria
    J Clin Microbiol 38:2638-42. 2000
    ..There was a correlation between the LC assay and the home-brew assay in 55 of 59 specimens. In conclusion, the LC assay allows very rapid detection of HSV DNA in CSF. It was found to be laborsaving and showed sufficient sensitivity...
  25. pmc Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
    M Lopez
    Institute of Cancerology and Immunology, INSERM U119, Marseille, France
    J Virol 74:1267-74. 2000
    ..Binding of wt HSV-1 gD to soluble nectin2 was not detectable. (iv) A major region of nectin2 functional in virus entry mapped to the V domain, located at the N terminus...
  26. pmc Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1
    Miri Yoon
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:9221-31. 2003
    ..The sequence of the N terminus determines whether nectin-2 or 3-O-sulfated heparan sulfate, as well as HVEM, can serve as entry/fusion receptors...
  27. ncbi Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1
    Richard M Coles
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 168:834-8. 2002
    ..This is followed by their dissemination to other compartments such as the spleen, where they further proliferate in an Ag-independent fashion...
  28. pmc Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection
    Martha Simpson-Holley
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, 02115, USA
    J Virol 79:12840-51. 2005
    ..From analyses of HSV infections under various conditions, we conclude that nuclear expansion and chromatin dispersal are dispensable for optimal replication, while lamina rearrangement is associated with efficient replication...
  29. pmc Herpes simplex virus triggers activation of calcium-signaling pathways
    Natalia Cheshenko
    Deparment of Pediatrics and Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 163:283-93. 2003
    ..Defining the pathway of viral invasion may lead to new targets for anti-viral therapy...
  30. ncbi Immune control of herpes simplex virus during latency
    Kamal M Khanna
    Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213 2588, USA
    Curr Opin Immunol 16:463-9. 2004
    ....
  31. pmc U(L)31 and U(L)34 proteins of herpes simplex virus type 1 form a complex that accumulates at the nuclear rim and is required for envelopment of nucleocapsids
    A E Reynolds
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
    J Virol 75:8803-17. 2001
    ....
  32. pmc PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B
    Takeshi Satoh
    Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Cell 132:935-44. 2008
    ..These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection...
  33. pmc Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts
    Roger D Everett
    MRC Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 81:10991-1004. 2007
    ..These observations illustrate that the intimate connections between HSV-1 genomes and ND10 that occur during lytic infection also extend to quiescent infections...
  34. pmc Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry
    C Krummenacher
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 72:7064-74. 1998
    ..Thus, we propose that HSV entry can be mediated by two structurally unrelated gD receptors through related but not identical binding with gD...
  35. pmc Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25
    David Pasdeloup
    MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 83:6610-23. 2009
    ....
  36. pmc Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response
    Dianna E Wilkinson
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Virol 78:4783-96. 2004
    ....
  37. pmc Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0
    Roger D Everett
    MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 78:1763-74. 2004
    ....
  38. pmc A role for heparan sulfate in viral surfing
    Myung Jin Oh
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochem Biophys Res Commun 391:176-81. 2010
    ..Our data demonstrates a novel use of a common receptor, HS, which could also be exploited by multiple viruses and quite possibly, many additional ligands for transport along the plasma membrane...
  39. pmc Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1
    Ashley P E Roberts
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 83:105-16. 2009
    ..Analysis of noninfectious enveloped particles (L-particles) further showed that pUL36 and pUL37 are dependent on each other for incorporation into tegument...
  40. pmc Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
    Jihan Akhtar
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    FEBS J 276:7228-36. 2009
    ..This minireview helps to shed light on recent revelations on the herpes simplex virus entry process...
  41. pmc Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26
    Katinka Döhner
    Institut fur Virologie, OE5230, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623 Hannover, Germany
    J Virol 80:8211-24. 2006
    ..Thus, even in the absence of the potential viral dynein receptor VP26, HSV-1 used MT and dynein for efficient nuclear targeting. These data suggest that besides VP26, HSV-1 encodes other receptors for dynein or dynactin...
  42. ncbi Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: implications for multiple sclerosis
    Klemens Ruprecht
    Department of Neurology, Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Wurzburg, Germany
    J Neurovirol 12:65-71. 2006
    ....
  43. pmc Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts
    Vaibhav Tiwari
    University of Illinois at Chicago, Lions of Illinois Eye Research Institute, M C 648, 1855 West Taylor Street, Chicago, IL 60612, USA
    J Virol 80:8970-80. 2006
    ..Taken together, the data in this report provide novel information on the role of 3-OS HS in mediating infection of CF, a natural target cell type...
  44. ncbi Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Blood 103:1433-7. 2004
    ....
  45. ncbi IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology
    Pranita P Sarangi
    Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
    J Immunol 180:6297-306. 2008
    ..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
  46. ncbi Activation of the human endogenous retrovirus W long terminal repeat by herpes simplex virus type 1 immediate early protein 1
    Woo Jung Lee
    Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609 735, Korea
    Mol Cells 15:75-80. 2003
    ....
  47. pmc Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:359-70. 2009
    ..Thus, both migrant and resident DCs play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo...
  48. ncbi Contribution of direct and cross-presentation to CTL immunity against herpes simplex virus 1
    Adan Chari Jirmo
    Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    J Immunol 182:283-92. 2009
    ..We conclude that cross-presentation is of major importance for the induction of CTL immunity in mice...
  49. ncbi Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States
    Fujie Xu
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 296:964-73. 2006
    ..Preexisting HSV-1 antibodies can alleviate clinical manifestations of subsequently acquired HSV-2. Furthermore, HSV-1 has become an important cause of genital herpes in some developed countries...
  50. pmc HSV-1 DNA in tears and saliva of normal adults
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:241-7. 2005
    ..To assess the frequency of shedding of herpes simplex virus type 1 (HSV-1) DNA in tears and saliva of asymptomatic individuals...
  51. ncbi Herpes simplex virus targeting to the EGF receptor by a gD-specific soluble bridging molecule
    Kenji Nakano
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Mol Ther 11:617-26. 2005
    ..These experiments represent the first demonstration that a soluble molecule can direct HSV infection via a new receptor, supporting the possible utility of this approach for HSV retargeting...
  52. ncbi Neonatal herpes simplex virus infection
    Richard Whitley
    University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Curr Opin Infect Dis 17:243-6. 2004
    ..This review considers recent advances that impact on disease management...
  53. pmc Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes
    Roger D Everett
    MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 78:1903-17. 2004
    ..This response is modulated by functional ICP0, and cells that are productively or nonproductively infected in the absence of functional ICP0 can be distinguished by the relative locations of ICP4 foci and ND10 proteins...
  54. pmc ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection
    Roger D Everett
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church St, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 79:5078-89. 2005
    ..These findings are discussed with reference to the nature, location, and potential number of HSV-1 prereplication compartments and to the dynamic aspects of HSV-1 genomes and viral products during the early stages of lytic infection...
  55. pmc Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7
    Chris Boutell
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 79:12342-54. 2005
    ..We propose that the biological significance of the ICP0-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP0 are expressed...
  56. ncbi Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0
    P Lomonte
    Medical Research Council Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
    J Biol Chem 276:5829-35. 2001
    ....
  57. pmc Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR
    Manfred Weidmann
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    J Clin Microbiol 41:1565-8. 2003
    ..In summary, TaqMan PCR is an excellent alternative to conventional nested PCR assays for the rapid detection of HSV-1, HSV-2, and VZV in clinical samples...
  58. pmc Transcriptional coactivators are not required for herpes simplex virus type 1 immediate-early gene expression in vitro
    Sebla B Kutluay
    Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Virol 83:3436-49. 2009
    ....
  59. pmc Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator
    A H Rux
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 72:7091-8. 1998
    ..The binding properties of any gD1(234t)-receptor complex could account for the inability of this form of gDt to block HSV infection...
  60. pmc A novel function of heparan sulfate in the regulation of cell-cell fusion
    Christopher D O'Donnell
    Department of Ophthalmology and Visual Sciences and the Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 284:29654-65. 2009
    ..This could serve as a possible explanation as to why HS-deficient cells showed significantly enhanced cell-cell fusion and suggests that HS could regulate fusion via fine tuning of RhoA and Cdc42 activities...
  61. ncbi Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1
    Guoqing Xia
    Cell and Molecular Biology, Biomedical Center C13, Lund University, Lund S 22184, Sweden
    J Biol Chem 277:37912-9. 2002
    ..These results provide a new insight regarding the mechanism for the biosynthesis of biologically active HS...
  62. pmc Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons
    T Liu
    Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2588, USA
    J Virol 75:11178-84. 2001
    ....
  63. ncbi Redundancy in the immune system restricts the spread of HSV-1 in the central nervous system (CNS) of C57BL/6 mice
    Lorne F Kastrukoff
    Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Virology 400:248-58. 2010
    ....
  64. ncbi A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1
    Vaibhav Tiwari
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Gen Virol 85:805-9. 2004
    ..Taken together, these results indicate that 3-OS HS can play a crucial role in virus entry and cell fusion...
  65. ncbi Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review
    Jennifer S Smith
    International Agency for Research on Cancer IARC, Unit of Field and Intervention Studies, 69372 Lyon, France
    J Infect Dis 186:S3-28. 2002
    ..HSV-1 infection is acquired during childhood and adolescence and is markedly more widespread than HSV-2 infection. Further studies are needed in many geographic areas...
  66. ncbi Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression
    P Brust
    Institute of Bioinorganic and Radiopharmaceutical Chemistry, Forschungszentrum, Rossendorf, Germany
    Eur J Nucl Med 28:721-9. 2001
    ..Thus, further attempts to develop suitable PET tracers for the assessment of HSV1-tk gene expression should also focus on 18F-labelled uracil derivatives...
  67. pmc Ultrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids
    Ashley E Reynolds
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
    J Virol 76:8939-52. 2002
    ..These data support the herpes simplex virus type 1 deenvelopment-reenvelopment model of virion egress and suggest that the US3 protein plays an important, but nonessential, role in the egress pathway...
  68. pmc A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2
    K J Looker
    Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Sex Transm Infect 81:103-7. 2005
    ..To explore epidemiological evidence about the interaction of herpes simplex virus (HSV) 1 and HSV-2 infections...
  69. pmc In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa
    Melissa M Linehan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 78:2530-6. 2004
    ..Together, these results suggest the importance of nectin-1 in mediating viral entry for both HSV-1 and HSV-2 in the genital mucosa in female hosts...
  70. pmc Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism
    Sharmila Manoj
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:12414-21. 2004
    ....
  71. ncbi Binding of human and animal immunoglobulins to the IgG Fc receptor induced by human cytomegalovirus
    A Antonsson
    Section of Virology, Department of Infectious Diseases and Medical Microbiology, University of Lund, , S-221 85 Lund, Sweden
    J Gen Virol 82:1137-45. 2001
    ....
  72. pmc Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100
    Roger D Everett
    MRC Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 82:2661-72. 2008
    ..These data lend further weight to the hypothesis that ND10 play an important role in the regulation of HSV-1 gene expression...
  73. pmc Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation
    David Khoo
    Department of Microbiology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Virol 76:11971-81. 2002
    ..The ability of Us11 to bind dsRNA may be important for inhibiting activation of the cellular PKR kinase in response to dsRNA...
  74. pmc New concepts in herpes simplex virus vaccine development: notes from the battlefield
    Gargi Dasgupta
    The Gavin S Herbert Eye Institute, Cellular and Molecular Immunology Laboratory, Department of Ophthalmology, University of California, Irvine, College of Medicine, Irvine, CA 92697 4375, USA
    Expert Rev Vaccines 8:1023-35. 2009
    ....
  75. pmc Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences
    N M Sawtell
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Virol 78:7784-94. 2004
    ..This ongoing neurodegeneration could alter even the early virus-host interactions in reactivation, and thus caution in the extrapolation of results obtained in explants to the in vivo interactions initiating reactivation is warranted...
  76. ncbi Natural history of neonatal herpes simplex virus infections in the acyclovir era
    D W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatrics 108:223-9. 2001
    ..The objective of this study was to provide an update of neonatal HSV disease to identify means by which future improvements in the management of HSV-infected neonates can be made...
  77. ncbi A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread
    Christopher D O'Donnell
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Virology 346:452-9. 2006
    ..Demonstrating specificity, the cell fusion was inhibited by soluble 3-O-sulfated forms of HS, but not unmodified HS. Taken together, our results raise the possibility of a role of 3-OST-2 in the spread of HSV-1 infection in the brain...
  78. ncbi Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans
    Magda Marchetti
    Department of Clinical Virology, Goteborg University, S 413 46 Goteborg, Sweden
    Virology 318:405-13. 2004
    ..The results support the hypothesis that the inhibition of HSV-1 infectivity by lactoferrin is dependent on its interaction with cell surface GAG chains of HS and CS...
  79. ncbi Herpes simplex virus-1 and varicella-zoster virus latency in ganglia
    Bradley M Mitchell
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    J Neurovirol 9:194-204. 2003
    ..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation...
  80. pmc Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G(1) into S phase of the cell cycle
    P Lomonte
    MRC Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 73:9456-67. 1999
    ..This factor is of obvious importance to the design of gene therapy vectors based on HSV-1...
  81. ncbi The immune response to ocular herpes simplex virus type 1 infection
    D J Carr
    Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Exp Biol Med (Maywood) 226:353-66. 2001
    ..Therefore, comments in this review will primarily be restricted to those observations pertaining to the mouse model and the assumption (however great) that similar events occur in the human condition...
  82. pmc Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1
    Ding Xu
    Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Biochem J 385:451-9. 2005
    ..The findings add to the growing body of evidence that HSV-1 entry is mediated by 3-O-sulphated HS generated by multiple members of 3-O-sulphotransferases...
  83. pmc Cytoplasmic domain of herpes simplex virus gE causes accumulation in the trans-Golgi network, a site of virus envelopment and sorting of virions to cell junctions
    T N McMillan
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Virol 75:1928-40. 2001
    ..Nascent virions are then sorted from the TGN to cell junctions...
  84. ncbi CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2
    Yanira Osorio
    Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars Sinai Burns and Allen Research Institute, CSMC D2024, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Exp Neurol 193:1-18. 2005
    ..However, T cell depletion studies suggest that only central memory CD8+ T cells are directly involved in the demyelination process, with macrophages being involved through a bystander effect...
  85. pmc Live-cell analysis of a green fluorescent protein-tagged herpes simplex virus infection
    G Elliott
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH1 0TL, United Kingdom
    J Virol 73:4110-9. 1999
    ..In this way, we have for the first time visualized the trafficking of a herpesvirus structural component within live, infected cells...
  86. pmc The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells
    F Cocchi
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Bologna, Italy
    J Virol 72:9992-10002. 1998
    ..The high level of expression in samples from nervous system makes the use of these proteins in human tissues very likely. This cluster of molecules may therefore be considered to constitute bona fide receptors for HSV-1 and HSV-2...
  87. pmc Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells
    Vaibhav Tiwari
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois, Chicago, IL, USA
    FEBS J 275:5272-85. 2008
    ..Our findings shed new light on the cellular and molecular mechanisms that help the virus to enter the cells of the inner eye...
  88. pmc New genes from old: redeployment of dUTPase by herpesviruses
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, University of Glasgow, UK
    J Virol 79:12880-92. 2005
    ..The findings clarify the evolutionary history of these genes and provide novel insights for structural and functional studies...
  89. ncbi Receptor cross-linking on human plasmacytoid dendritic cells leads to the regulation of IFN-alpha production
    Stacey L Fanning
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Immunol 177:5829-39. 2006
    ....
  90. pmc During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription
    J R Kent
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Virol 78:10178-86. 2004
    ..These data suggest that productive infection may be accompanied by acquisition of a permissive chromatin state...
  91. pmc Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes
    Malgorzata Gierynska
    Department of Microbiology, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Virol 76:6568-76. 2002
    ..Still, our results indicate that the CpG ODN-peptide immunization system holds promise as a means of selectively inducing a CD8+ T-cell response against HSV...
  92. ncbi Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention
    W E Lafferty
    Dept of Health Services, University of Washington, Seattle, WA 98195 7660, USA
    J Infect Dis 181:1454-7. 2000
    ..Genital HSV-1 may often be acquired through contact with a partner's mouth. These data suggest that seroprevalence studies based solely on HSV-2 type-specific assays underestimate overall prevalence of genital HSV infection...
  93. pmc Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB)
    F Cocchi
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, 40126 Bologna, Italy
    J Virol 74:3909-17. 2000
    ....
  94. ncbi Combinatorial transcription of herpes simplex virus and varicella zoster virus immediate early genes is strictly determined by the cellular coactivator HCF-1
    Aarthi Narayanan
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:1369-75. 2005
    ..The requirements for this protein supports the model whereby the regulated transport of HCF-1 from the cytoplasm to the nucleus in sensory neurons may control IE gene expression and reactivation of these viruses from the latent state...
  95. ncbi Herpes simplex virus replication compartments can form by coalescence of smaller compartments
    Travis J Taylor
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Virology 309:232-47. 2003
    ....
  96. ncbi Inhibition of dendritic cell maturation by herpes simplex virus
    M Salio
    Basel Institute for Immunology Basel, Switzerland
    Eur J Immunol 29:3245-53. 1999
    ..These results reveal yet another strategy used by HSV-1 to evade the immune response, namely the inhibition of signaling pathways involved in DC maturation...
  97. ncbi Epidemiology of genital herpes simplex virus infections in a community-based sample in France: results of the HERPIMAX study
    Denis Malvy
    EA 3677, Universite Bordeaux 2, France
    Sex Transm Dis 32:499-505. 2005
    ..The objective of this study was to provide information on the prevalence of herpes simplex infections in the general population in Europe...
  98. ncbi Role of Stat4-mediated signal transduction events in the generation of aggressor CD4+ T cells in herpetic stromal keratitis pathogenesis
    Kaustuv Banerjee
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37916, USA
    J Interferon Cytokine Res 27:65-75. 2007
    ..The data imply a significant role of Stat4-mediated signaling events in the generation of an aggressor CD4(+) T cell population in stromal keratitis pathogenesis...
  99. ncbi Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation
    Allison van Lint
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Immunol 172:392-7. 2004
    ..Therefore, we propose that the role of CD8+ T cells during the normal course of disease is to clear replicating virus after infection is well established rather than limit the initial spread of HSV from the primary site of inoculation...
  100. ncbi Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus
    Claude Krummenacher
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Virology 322:286-99. 2004
    ..Overall, our data suggest that both receptors play a role during HSV infection in vivo and that both are highly efficient even at low levels of expression...
  101. pmc Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses
    Peter K Hocknell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Virol 76:5565-80. 2002
    ..Taken together, these data strongly support the use of helper-free HSV-1 amplicon particles as vaccine delivery vectors...

Research Grants67

  1. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..Alternatively, mediators of neuropathogenesis can be targeted to alleviate collateral damage and thus, preservation of neurons in patients that suffer from acute or recurrent HSV-1 CNS or peripheral nerve infection. ..
  2. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    ..The completion of this proposal will shed light on the molecular mechanism of HSV-1 mediated Egr1 expression and assist to develop new strategy to prevent viral replication and blindness caused by HSV-1. ..
  3. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ....
  4. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..Our work will be critical for a better understanding nociceptor pathways and processes underlying hypersensitivity pain and may ultimately lead to novel targets for its treatment. ..
  5. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..Having met all previous milestones, we propose to file for FDA approval towards the end of this U01 proposal. ..
  6. CYTOTOXIC LYMPHOCYTES AND HSV-1 CORNEAL LESIONS
    Robert L Hendricks; Fiscal Year: 2013
    ..abstract_text> ..
  7. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    ..This could indicate those HSV-1 proteins that could be potentially exploited in vaccine design to block reactivation when immunological pressure causes loss of immunodominant epitopes. ..
  8. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..Our innovative approach will define potential agents for neurotrophic keratitis and dry eye after refractive surgery and HSV-1 infection. ..
  9. Screens for host DNA replication and repair factors involved in viral infection
    Matthew D Weitzman; Fiscal Year: 2010
    ..These screens will identify cellular factors that regulate viral infection, will provide insights into virus-host interactions and fundamental cellular processes, and may suggest targets for anti-viral therapies. ..
  10. Corneal Lymphatics &Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2013
    ..abstract_text> ..
  11. SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANS
    Robert J Linhardt; Fiscal Year: 2012
    ..Currently it is difficult to analyze and not possible to sequence these complex polysaccharides. This has prevented a firm understanding of the structure- activity relationship of this important class of biomacromolecules. ..
  12. Genomic systems approach to measure HSV-1-specific T-cell dominance in humans
    David M Koelle; Fiscal Year: 2013
    ..The overall goal of the Project is to identify HSV-1 ORFs for vaccines that stimulate dominant and prevalent CD8 and CD4 epitopes to persons of diverse HLA type that are correlated with mild infection. ..
  13. Virus-Cell Interaction Affecting HSV Gene Expression
    Neal A DeLuca; Fiscal Year: 2013
    ..Detailed knowledge of how HSV genes are transcribed and what interactions contribute to their regulated expression may allow for strategies to block activated transcription and hence virus multiplication. ..
  14. Corneal Expression and Function of Slurp1
    SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2013
    ..The anticipated outcomes will define a novel target for therapeutic intervention in managing inflammatory disorders of the ocular surface. ..
  15. Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 Entry
    Vaibhav Tiwari; Fiscal Year: 2011
    ..Apart from that, our aim is to identify novel peptides to inhibit HSV-1 entry and spread in embryo model of ZF. ..
  16. HSV-1 LAT miRNAs: Neurovirulence, reactivation, mechanism
    Steven L Wechsler; Fiscal Year: 2013
    ..3) Test the hypothesis that the mechanism(s) by which LAT miRNAs influence neurovirulence and/or reactivation is to alter expression of viral genes involved in neurovirulence and reactivation. ..
  17. Molecular Genetics of HSV Reactivation
    David C Bloom; Fiscal Year: 2013
    ..In addition this work may provide new insight into novel mechanisms of PRC regulation of cellular genes. ..
  18. Do the B2 and Alu ncRNAs Repress Host Cell mRNA Transcription During HSV-1 Infect
    James Goodrich; Fiscal Year: 2013
    ....
  19. Structures of the portal vertex in dsDNA viruses and virus-infected cells
    Wah Chiu; Fiscal Year: 2011
    ..Our technical approaches and biological insights will be transformative in the study of viruses, not only in biochemically purified states, but also in their native cellular environments. ..
  20. Circumventing Barriers to Effective Oncolytic Virotherapy of Malignant Gliomas
    E Antonio Chiocca; Fiscal Year: 2013
    ....
  21. Role of DNA damage in the early steps of HSV infection and latency in neurons
    Matthew D Weitzman; Fiscal Year: 2013
    ..Knowledge of HSV-1 neuronal latency will suggest novel targets for developing antivirals against this significant human pathogen. ..
  22. MECHANISMS OF DNA REPLICATION AND RECOMBINATION IN HSV-1
    Paul E Boehmer; Fiscal Year: 2010
    ..They will also increase our overall knowledge of fundamental mechanisms in replication and recombination. ..
  23. Regulation of lytic and latent infection by HSV-1 encoded miRNAs
    David C Bloom; Fiscal Year: 2013
    ....
  24. Alpha-Herpesvirus Transport on Axons
    Gregory Allan Smith; Fiscal Year: 2013
    ..This proposal focuses on understanding the cellular mechanisms used by herpesviruses to spread within the nervous system and cause disease, with the long term goal of developing new treatments to intervene with disease progression. ..
  25. Characterization of the antiviral and nuclear regulatory functions of FEZ1 &NEK1
    MOJGAN HOSSEINI NAGHAVI; Fiscal Year: 2013
    ..As such, these studies are also likely to contribute to our broader understanding of the control of nuclear transport and architecture. ..
  26. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents
    Terry L Bowlin; Fiscal Year: 2013
    ....
  27. Characterization of Antiviral Functions of Sterile Alpha Motif-Containing Domain
    Jia Liu; Fiscal Year: 2013
    ..This is crucial for an in-depth understanding of human cellular innate immune mechanisms that must cope with viruses of many distinct types. ..
  28. Modification of a Tegument Protein during the Assembly of HSV-1
    Richard J Courtney; Fiscal Year: 2010
    ..An understanding of these dynamic events that occur within the virus may provide insight as to new targets for disrupting the assembly of this human virus. ..
  29. TNF SIGNALING IN THE ABSENCE OF FUNCTIONAL TNF RECEPTORS.
    EDOUARD M CANTIN; Fiscal Year: 2012
    ..Results from these studies will significantly enhance understanding TNF signaling in the context of innate immunity, in various autoimmune diseases in which TNF plays a central role as well as in regulation of inflammation. ..
  30. Innate Immunity and Herpes Simplex Pathogensis
    Robert Finberg; Fiscal Year: 2009
    ..abstract_text> ..
  31. Virulence Genes in Herpes Simplex Virus Ocular Infection
    Curtis R Brandt; Fiscal Year: 2013
    ..This highly novel approach will allow us to identify the contribution of multiple genes in virulence and potentially identify a role for epistasis in determining the virulence phenotype of a given virus. ..
  32. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Donald M Coen; Fiscal Year: 2010
    ..Collectively, these studies will provide new insight into the mechanisms of HSV-1 latency and reactivation and define novel approaches to intervention in the HSV-1 life-cycle...
  33. Personality, Stress, and HSV-1 Infection: A Twin Study
    ERIC DANIEL STRACHAN; Fiscal Year: 2010
    ..In this study, we will examine the relationships among personality, stress, and HSV-1 in twins to better elucidate how the person, the virus, and the environment interact. ..
  34. Role of Optineurin in Ocular Herpes Infection
    Deepak Shukla; Fiscal Year: 2013
    ..Overall, our studies are expected to shed new lights, and for the first time, implicate OPTN as an important co-factor in HSV-1 infection of the cells in the cornea. ..
  35. Glycine Receptor Expression in Sensory Afferents to Modulate Pain Signaling
    Joseph C Glorioso; Fiscal Year: 2013
    ....
  36. Alpha-Herpevirus Transport in Axons
    Gregory Smith; Fiscal Year: 2009
    ..abstract_text> ..
  37. The Role of VP22 in Protein Synthesis and mRNA Accumulation During HSV-1 Infectio
    CAROL LYNN DUFFY; Fiscal Year: 2010
    ..The studies proposed herein will enable us to elucidate mechanisms utilized by HSV-1 for virus replication and spread as a prerequisite to the development of improved therapeutics for use in attenuating the above diseases. ..
  38. Preclinical Toxicity Evaluation of a Potent Oncolytic Virus
    E Antonio Chiocca; Fiscal Year: 2012
    ..5v.2 + CPA immunomodulation and subsequently a phase I trial in newly diagnosed glioma using rQNestin34.5v.2 + CPA immunomodulation + standard therapy. ..
  39. Ocular Lymphangiogenesis
    DANIEL J CARR; Fiscal Year: 2010
    ....
  40. Avirulent CD8+ T-cell Evading Oncolytic HSV-1 for the Treatment of Bladder Cancer
    MATTHEW CHARLES MULVEY; Fiscal Year: 2012
    ..We believe this could be safer and more effective that existing treatments. ..
  41. Corneal HSV-1: Newly discovered LAT miRNAs and latency
    Steven L Wechsler; Fiscal Year: 2011
    ..The approach and analyses are similar to those in aim 1. In addition, a mutant knocked out for all 6 LAT miRNAs (Δ6KO) will also be constructed and analyzed as above. ..
  42. Significance of heparan sulfate in HSV-1 spread
    Deepak Shukla; Fiscal Year: 2013
    ..The virus via its envelope proteins interacts with receptors on our cells and this interaction is crucial for the initiation of the infection. Our research may suggest new strategies to stop virus transmission and spread among humans. ..
  43. Bell's Palsy-Randomized Clinical Trial
    John Neely; Fiscal Year: 2007
    ..This revised planning grant application is to support necessary preparation for the multicenter trial. [unreadable] [unreadable] [unreadable]..
  44. Membrane fusion during HSV-1 entry
    ROBERT JAMES GERAGHTY; Fiscal Year: 2010
    ..HSV-1 enters cells by multiple routes so the intricate understanding of the mechanism of each route is required to facilitate the design of anti-virals to block virus entry and spread. ..
  45. Genetics and Functions of HSV Membrane Fusion Proteins
    KONSTANTIN KOUSOULAS; Fiscal Year: 2009
    ....
  46. IMPROVING SUICIDE GENES FOR CANCER GENE THERAPY
    Margaret Black; Fiscal Year: 2009
    ..abstract_text> ..
  47. MOLECULAR ANALYSIS OF CARCINOGEN-INDUCED MUTATIONS
    Norman Drinkwater; Fiscal Year: 1992
    ....
  48. IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATION
    JOHN KRIESEL; Fiscal Year: 2002
    ..Novel and specific viral mutants will be constructed based on the results of HSV-DNA binding and transient expression assays. ..
  49. Innate & adaptive immunities in control of ocular HSV
    Homayon Ghiasi; Fiscal Year: 2007
    ....
  50. Anti-Viral Gene Delivery in the Nervous System
    Daniel Carr; Fiscal Year: 2005
    ..abstract_text> ..
  51. Modification of RNA polymerase II by HSV-1 proteins
    Stephen Rice; Fiscal Year: 2006
    ..This research will also help to elucidate the fundamental replication mechanisms of HSV-1 and other pathogenic herpesviruses. ..
  52. MECHNISM OF HERPES ST ROMAL KERATITIS
    Edouard Cantin; Fiscal Year: 2001
    ..Given that sex hormones are known to affect antigen presentation we propose examining their effects on inflammatory responses mediated by HSV-1 DNA in vitro and the incidence and/or severity of HSK in vivo. ..
  53. Retargeting HSV-1 Vectors to Motor Neurons
    Joseph Glorioso; Fiscal Year: 2005
    ..The soluble HveC adapter will be expected to block gD binding to cellular HveC while directly or indirectly re-targeting the virus to TTx receptors. ..
  54. MOLECULAR CHARACTERIZATION OF HERPES SIMPLEX VIRUS ICP27
    Stephen Rice; Fiscal Year: 2003
    ..Overall, this research will increase our understanding of pathogenic herpesviruses and provide novel insight into post-transcriptional gene regulation. ..
  55. NEUROENDOCRINE REGULATION OF HSV 1 INDUCED CYTOKINES
    GRISELLE ORTIZ; Fiscal Year: 2001
    ..Correlations of the clinical, histological, and immunological findings will be done in order to understand the mechanisms in which restrain stress modulates HSV-1 infections. ..
  56. TRANS-ACTIVATED EXPRESSION OF HSV IMMEDIATE EARLY GENES
    STEVEN TRIEZENBERG; Fiscal Year: 2001
    ..These experiments will bring a greater understanding not only of VP16 as a model transcriptional activator, but also of VP16 in its biological role as a key regulator of gene expression of an important human pathogen. ..
  57. HSV 1 PROCESSING/PACKAGING GENES
    Sandra K Weller; Fiscal Year: 2010
    ..This grant will further our understanding of the mechanism by which this occurs and provide novel strategies for future antiviral therapies. - ..
  58. Maintenance of Herpes Simplex Type 1 Neuronal Latency by CD8 T cells
    JARED EVAN KNICKELBEIN; Fiscal Year: 2010
    ..Therefore, understanding the protective immune response to latent HSV-1 neuronal infection in hopes of developing an immune-based therapeutic vaccine to inhibit HSV-1 reactivation is an important global public health issue. ..
  59. STRUCTURAL STUDIES OF HERPESVIRUS CAPSIDS
    Wah Chiu; Fiscal Year: 2005
    ..The outcome of our investigations will provide insights on the structural assembly of this important human pathogen and also advance the structural approaches for studying large macromolecular machines. ..
  60. Ocular HSV-1, Stromal Keratitis, & T Cell Costimulation
    Byoung Kwon; Fiscal Year: 2006
    ..These studies will aid in understanding the immunological mechanisms involved in the blinding eye condition, HSK, and allow development of strategies for the treatment of this and other ocular inflammatory diseases. ..
  61. Gene Therapy for Glioma
    Pedro Lowenstein; Fiscal Year: 2004
    ..Our long term aim is to translate this novel therapeutic approach into a Phase I clinical trial for GBM. ..
  62. PROPERTIES OF HSV-1 GYLCOPROTEINS AND MEMBRANE PROTEINS
    Thomas Holland; Fiscal Year: 1992
    ..Several methods will be used to identify the primary translation product of this gene, including the production of antibodies against synthetic peptides and in vitro translation of messenger RNA...
  63. MECHANISMS OF THE HSV-1 UL42 PROTEIN
    DEBORAH PARRIS; Fiscal Year: 2002
    ..It is important to understand an the mechanism of UL42 action since disruption of the pol/UL42 complex has been proposed for development of antivirals. ..
  64. FUNCTION AND ROLE OF HSV-1 ICP34.5 IN ENCEPHALITIS
    KENNETH ROSENTHAL; Fiscal Year: 2000
    ..5 variants in neuronal and other cells and a mouse model of encephalitis and also the protein expressed from eukaryotic expression vectors containing PCR amplified ICP34.5 gene sequences from the same variants. ..
  65. GLYCOSAMINOGLYCAN RECEPTORS FOR HSV-1 AND HSV-2
    Betsy Herold; Fiscal Year: 1999
    ....
  66. Ocular HSV-1: Preventing Recurrent Corneal Disease
    STEVEN WECHSLER; Fiscal Year: 2004
    ..3) Determine the optimal HIMII treatment regimen required for optimal suppression of HSV-1 spontaneous reactivation. ..
  67. HERPES SIMPLEX VIRUS TYPE 1 GLYCOPROTEINS
    Subhendra Chattopadhyay; Fiscal Year: 1990
    ..Finally, the roles of glycoproteins in viral assembly and in induction of cell fusion will be studied through mammalian cell lines expressing cloned glycoprotein genes and by the analysis of deletion mutants in these glycoprotein genes...