infectious bursal disease virus

Summary

Summary: A species of AVIBIRNAVIRUS causing severe inflammation of the bursa of Fabricius in chickens and other fowl. Transmission is thought to be through contaminated feed or water. Vaccines have been used with varying degrees of success.

Top Publications

  1. ncbi Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus
    C C Wu
    Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 1175, USA
    Vet Immunol Immunopathol 74:145-52. 2000
  2. ncbi Infectious Bursal disease virus: ribonucleoprotein complexes of a double-stranded RNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, C Darwin No 3, Cantoblanco, E 28049 Madrid, Spain
    J Mol Biol 386:891-901. 2009
  3. ncbi Alteration of amino acids in VP2 of very virulent infectious bursal disease virus results in tissue culture adaptation and attenuation in chickens
    A A W M van Loon
    Intervet International BV, PO Box 31, 5830 AA Boxmeer, The Netherlands
    J Gen Virol 83:121-9. 2002
  4. ncbi Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: implications in virion assembly and immunogenicity
    Cheng Chung Lee
    Structural Biology Program, Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 11221, Taiwan, ROC
    J Struct Biol 155:74-86. 2006
  5. ncbi Characterization of the RNA-binding activity of VP3, a major structural protein of Infectious bursal disease virus
    G Kochan
    Departamento de Biologia Molecular y Celular, Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, Madrid, Spain
    Arch Virol 148:723-44. 2003
  6. pmc Infectious bursal disease virus capsid protein VP3 interacts both with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA
    Mirriam G J Tacken
    Division of Infectious Diseases and Food Chain Quality, Institute for Animal Science and Health ID Lelystad B V, NL 8200 AB Lelystad, The Netherlands
    J Virol 76:11301-11. 2002
  7. ncbi Structural polymorphism of the major capsid protein of a double-stranded RNA virus: an amphipathic alpha helix as a molecular switch
    Irene Saugar
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Structure 13:1007-17. 2005
  8. pmc Rescue of very virulent and mosaic infectious bursal disease virus from cloned cDNA: VP2 is not the sole determinant of the very virulent phenotype
    H J Boot
    Department of Avian Virology, Institute for Animal Science and Health, Lelystad, The Netherlands
    J Virol 74:6701-11. 2000
  9. pmc Infectious bursal disease virus is an icosahedral polyploid dsRNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, Cantoblanco, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 106:2148-52. 2009
  10. ncbi Current status of vaccines against infectious bursal disease
    Hermann Muller
    Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, Leipzig, Germany
    Avian Pathol 41:133-9. 2012

Research Grants

  1. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward H Egelman; Fiscal Year: 2012

Detail Information

Publications230 found, 100 shown here

  1. ncbi Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus
    C C Wu
    Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 1175, USA
    Vet Immunol Immunopathol 74:145-52. 2000
    ..05). Dietary supplementation of ascorbic acid may ameliorate the immunosuppression caused by IBDV vaccination and improve humoral and cellular immune responses...
  2. ncbi Infectious Bursal disease virus: ribonucleoprotein complexes of a double-stranded RNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, C Darwin No 3, Cantoblanco, E 28049 Madrid, Spain
    J Mol Biol 386:891-901. 2009
    ..We used electron microscopy and functional analysis to characterize these RNP complexes of infectious bursal disease virus, the best characterized member of the Birnaviridae family...
  3. ncbi Alteration of amino acids in VP2 of very virulent infectious bursal disease virus results in tissue culture adaptation and attenuation in chickens
    A A W M van Loon
    Intervet International BV, PO Box 31, 5830 AA Boxmeer, The Netherlands
    J Gen Virol 83:121-9. 2002
    Reverse genetics technology offers the possibility to study the influence of particular amino acids of infectious bursal disease virus (IBDV) on adaptation to tissue culture...
  4. ncbi Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: implications in virion assembly and immunogenicity
    Cheng Chung Lee
    Structural Biology Program, Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 11221, Taiwan, ROC
    J Struct Biol 155:74-86. 2006
    The structural protein VP2 of infectious bursal disease virus (IBDV) spontaneously forms a dodecahedral T=1 subviral particle (SVP), and is a primary immunogen of the virus...
  5. ncbi Characterization of the RNA-binding activity of VP3, a major structural protein of Infectious bursal disease virus
    G Kochan
    Departamento de Biologia Molecular y Celular, Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, Madrid, Spain
    Arch Virol 148:723-44. 2003
    b>Infectious bursal disease virus (IBDV) is the agent of an immune-depressive disease affecting the poultry industry worldwide. Infection of IBDV leads to expression of five mature virus-encoded proteins...
  6. pmc Infectious bursal disease virus capsid protein VP3 interacts both with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA
    Mirriam G J Tacken
    Division of Infectious Diseases and Food Chain Quality, Institute for Animal Science and Health ID Lelystad B V, NL 8200 AB Lelystad, The Netherlands
    J Virol 76:11301-11. 2002
    b>Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus of the Birnaviridae family...
  7. ncbi Structural polymorphism of the major capsid protein of a double-stranded RNA virus: an amphipathic alpha helix as a molecular switch
    Irene Saugar
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Structure 13:1007-17. 2005
    The infectious bursal disease virus T=13 viral particle is composed of two major proteins, VP2 and VP3...
  8. pmc Rescue of very virulent and mosaic infectious bursal disease virus from cloned cDNA: VP2 is not the sole determinant of the very virulent phenotype
    H J Boot
    Department of Avian Virology, Institute for Animal Science and Health, Lelystad, The Netherlands
    J Virol 74:6701-11. 2000
    ..disease in commercial chicken flocks worldwide are due to the spread of very virulent strains of infectious bursal disease virus (vvIBDV)...
  9. pmc Infectious bursal disease virus is an icosahedral polyploid dsRNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, Cantoblanco, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 106:2148-52. 2009
    ..We performed an in-depth characterization of infectious bursal disease virus (IBDV), a non-enveloped icosahedral dsRNA virus with a bisegmented genome...
  10. ncbi Current status of vaccines against infectious bursal disease
    Hermann Muller
    Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, Leipzig, Germany
    Avian Pathol 41:133-9. 2012
    b>Infectious bursal disease virus (IBDV) is the aetiological agent of the acute and highly contagious infectious bursal disease (IBD) or "Gumboro disease"...
  11. ncbi Development of reverse-transcription loop-mediated isothermal amplification for the detection of infectious bursal disease virus
    Jiangtao Xu
    College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China
    J Virol Methods 162:267-71. 2009
    ..reverse-transcription loop-mediated isothermal amplification (RT-LAMP) method for rapid detection of infectious bursal disease virus (IBDV), four primers specific to six regions of the VP3 gene were designed; the VP3 region was ..
  12. ncbi The VP5 protein of infectious bursal disease virus promotes virion release from infected cells and is not involved in cell death
    Yongping Wu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention, Ministry of Agriculture, Zhejiang University, Zhejiang, People s Republic of China
    Arch Virol 154:1873-82. 2009
    The VP5 protein of infectious bursal disease virus (IBDV) was shown in previous reports to be involved in the cytopathogenicity of IBDV...
  13. ncbi Reversion of molecularly engineered, partially attenuated, very virulent infectious bursal disease virus during infection of commercial chickens
    R Raue
    Institute for Virology, Faculty of Veterinary Medicine University of Leipzig D 04103 Leipzig
    Avian Pathol 33:181-9. 2004
    A molecularly cloned, tissue culture-adapted infectious bursal disease virus (BD-3tc) was generated from a very virulent strain by the reverse genetics approach following site-directed mutagenesis (Q253H and A284T in VP2)...
  14. ncbi Protection of chickens, with or without maternal antibodies, against IBDV infection by a recombinant IBDV-VP2 protein
    Xuemei Zhou
    College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
    Vaccine 28:3990-6. 2010
    ..The use of avian herpesviruses (Marek's disease virus, MDV) as vectors to express the capsid protein of infectious bursal disease virus (IBDV) was well established, and its protection against IBDV challenge has been evaluated previously...
  15. pmc The 2.6-Angstrom structure of infectious bursal disease virus-derived T=1 particles reveals new stabilizing elements of the virus capsid
    Damiá Garriga
    Institut de Biologia Molecular Barcelona, CSIC, Josep Samitier 1 5, 08028 Barcelona, Spain
    J Virol 80:6895-905. 2006
    b>Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is a double-stranded RNA virus that causes a highly contagious disease in young chickens leading to significant economic losses in the poultry industry...
  16. pmc The oligomerization domain of VP3, the scaffolding protein of infectious bursal disease virus, plays a critical role in capsid assembly
    Antonio Maraver
    Department of Biología Molecular y Celular, Centro Nacional de Biotecnologia, Cantoblanco, 28049 Madrid, Spain
    J Virol 77:6438-49. 2003
    b>Infectious bursal disease virus (IBDV) capsids are formed by a single protein layer containing three polypeptides, pVP2, VP2, and VP3...
  17. pmc Identification and molecular characterization of the RNA polymerase-binding motif of infectious bursal disease virus inner capsid protein VP3
    Antonio Maraver
    Departamento de Biologia Molecular y Celular, Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 77:2459-68. 2003
    b>Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is the causative agent of one of the most important infectious poultry diseases...
  18. ncbi VP1 protein of infectious bursal disease virus modulates the virulence in vivo
    Meihong Liu
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Virology 330:62-73. 2004
    ..Taken together, our results demonstrate that the VP1 protein of IBDV is involved in the efficiency of viral replication and modulates the virulence in vivo...
  19. pmc Complete, long-lasting protection against lethal infectious bursal disease virus challenge by a single vaccination with an avian herpesvirus vector expressing VP2 antigens
    K Tsukamoto
    Department of Infectious Diseases, National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Virol 76:5637-45. 2002
    ..In this study, two herpesvirus of turkey recombinants (rHVTs) expressing large amounts of infectious bursal disease virus (IBDV) VP2 antigen under the control of a human cytomegalovirus (CMV) promoter or CMV/beta-actin ..
  20. pmc Adaptation of very virulent infectious bursal disease virus to chicken embryonic fibroblasts by site-directed mutagenesis of residues 279 and 284 of viral coat protein VP2
    B L Lim
    Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Virol 73:2854-62. 1999
    The full-length RNA genomes of a chicken embryonic fibroblast (CEF)-nonpermissive, very virulent infectious bursal disease virus (IBDV) (strain HK46) were amplified into cDNAs by reverse transcription-PCR...
  21. ncbi Protection of chickens against very virulent infectious bursal disease virus (IBDV) and Marek's disease virus (MDV) with a recombinant MDV expressing IBDV VP2
    K Tsukamoto
    Department of Virology, National Institute of Animal Health, Tsukuba, Japan
    Virology 257:352-62. 1999
    ..for an extended period, a recombinant Marek's disease (MD) virus (MDV) CVI-988 strain expressing infectious bursal disease virus (IBDV) host-protective antigen VP2 at the US2 site (rMDV) was developed under the control of an SV40 ..
  22. pmc Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus
    Tobias Letzel
    Institute of Molecular Biology, Federal Research Institute for Animal Health, Boddenblick 5a, 17493 Greifswald Insel Riems, Germany
    J Virol 81:12827-35. 2007
    b>Infectious bursal disease virus (IBDV), a member of the family Birnaviridae, is responsible for a highly contagious and economically important disease causing immunosuppression in chickens...
  23. ncbi Transcriptional profiles of chicken embryo cell cultures following infection with infectious bursal disease virus
    Y P Li
    Department of Poultry, Fish and Fur Animals, Danish Institute for Food and Veterinary Research, Aarhus, Denmark
    Arch Virol 152:463-78. 2007
    b>Infectious bursal disease virus (IBDV) is the causative agent of infectious bursal disease in chickens and causes a significant economic loss for the poultry industry...
  24. ncbi Identification and characterization of two distinct bursal B-cell subpopulations following infectious bursal disease virus infection of White Leghorn chickens
    Daniel I Petkov
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Avian Dis 53:347-55. 2009
    b>Infectious bursal disease virus (IBDV) is an immunosuppressive virus which primarily infects IgM B-cells in the bursa of Fabricius...
  25. ncbi Naturally occurring mutations at residues 253 and 284 in VP2 contribute to the cell tropism and virulence of very virulent infectious bursal disease virus
    Xiaole Qi
    Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, PR China
    Antiviral Res 84:225-33. 2009
    b>Infectious bursal disease virus (IBDV) is responsible for the highly contagious infectious bursal disease in chickens...
  26. ncbi Studies on naturally occurring infectious bursal disease viruses suggest that a single amino acid substitution at position 253 in VP2 increases pathogenicity
    D J Jackwood
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Virology 377:110-6. 2008
    ..Together, the molecular and pathogenicity data indicate that a single amino acid mutation from Histidine (H) to Glutamine (Q) or Asparagine (N) at position 253 in VP2 will markedly increase the virulence of an attenuated IBDV...
  27. ncbi Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2
    E Mundt
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Insel Riems, Germany
    J Gen Virol 80:2067-76. 1999
    Two types of strains of serotype I of infectious bursal disease virus (IBDV) have been described, on the basis of their ability (IBDV-TC) or inability (IBDV-BU) to infect chicken embryonic cells in culture...
  28. ncbi The enhanced virulence of very virulent infectious bursal disease virus is partly determined by its B-segment
    H J Boot
    Animal Sciences Group, Wageningen University and Research Centre, Lelystad, The Netherlands
    Arch Virol 150:137-44. 2005
    There is a remarkable difference in virulence of infectious bursal disease virus (IBDV) strains ranging from sub-clinical infections for serotype 2 and cell culture adapted serotype 1 strains, to 100% mortality for very virulent serotype ..
  29. ncbi Identification of sequence changes responsible for the attenuation of highly virulent infectious bursal disease virus
    T Yamaguchi
    Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Japan
    Virology 223:219-23. 1996
    The genetic changes responsible for the attenuation of infectious bursal disease virus (IBDV) have not been defined at the molecular level, although passage of the virus in cell culture results in the loss of virulence...
  30. ncbi Oral DNA vaccination with the polyprotein gene of infectious bursal disease virus (IBDV) delivered by the attenuated Salmonella elicits protective immune responses in chickens
    Long Li
    Institute of Protective Veterinary, College of Animal Science, Zhejiang University, Hangzhou, 310029, PR China
    Vaccine 24:5919-27. 2006
    Our previous study showed that vaccination with plasmid DNA containing infectious bursal disease virus (IBDV) gene which encodes complete polyprotein (VP2/4/3) induced protective immune responses...
  31. ncbi Rapid detection of Infectious bursal disease virus by reverse transcription loop-mediated isothermal amplification assay
    Chunyi Xue
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, PR China
    J Vet Diagn Invest 21:841-3. 2009
    ..loop-mediated isothermal amplification (RT-LAMP) assay was developed for the rapid identification of Infectious bursal disease virus (IBDV)...
  32. pmc Self-guanylylation of birnavirus VP1 does not require an intact polymerase activity site
    Junhua Pan
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX 77005, USA
    Virology 395:87-96. 2009
    ..The guanylylation site was further mapped to the VP1 N-terminal domain. Our results support a mechanism in which VP1 self-guanylylation is catalyzed by a novel active site different from the polymerase active site...
  33. pmc A one-step reverse transcription loop-mediated isothermal amplification for detection and discrimination of infectious bursal disease virus
    Yongqiang Wang
    Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150001, China
    Virol J 8:108. 2011
    ..bursal disease (IBD) is a highly contagious immunosuppressive disease in young chickens caused by infectious bursal disease virus (IBDV). It causes huge economic losses to the poultry industry...
  34. ncbi Oral immunization with transgenic rice seeds expressing VP2 protein of infectious bursal disease virus induces protective immune responses in chickens
    Jianxiang Wu
    State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou 31009, China
    Plant Biotechnol J 5:570-8. 2007
    The expression of infectious bursal disease virus (IBDV) host-protective immunogen VP2 protein in rice seeds, its immunogenicity and protective capability in chickens were investigated...
  35. ncbi Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, 55108, USA
    Virus Res 118:70-7. 2006
    In the present study, we show that infection with infectious bursal disease virus (IBDV) causes activation of macrophages, the key cells involved in inflammatory and immune-regulatory functions...
  36. ncbi Comparative study of the replication of infectious bursal disease virus in DF-1 cell line and chicken embryo fibroblasts evaluated by a new real-time RT-PCR
    Yongqiang Wang
    Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Heilongjiang, China
    J Virol Methods 157:205-10. 2009
    A real-time RT-PCR method was developed for the detection of infectious bursal disease virus (IBDV). The VP5 gene of IBDV was chosen as the target binding region for a specific TaqMan probe...
  37. ncbi Research on infectious bursal disease--the past, the present and the future
    Hermann Muller
    Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D 04103 Leipzig, Germany
    Vet Microbiol 97:153-65. 2003
    ....
  38. ncbi Infectious bursal disease virus of chickens: pathogenesis and immunosuppression
    J M Sharma
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Dev Comp Immunol 24:223-35. 2000
    b>Infectious bursal disease virus (IBDV) is an important immunosuppressive virus of chickens. The virus is ubiquitous and, under natural conditions, chickens acquire infection by the oral route. IgM+ cells serve as targets for the virus...
  39. ncbi Changes in VP2 gene during the attenuation of very virulent infectious bursal disease virus strain Gx isolated in China
    X M Wang
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Science, 427 Maduan Street, 150001, Harbin, P R China
    Avian Dis 48:77-83. 2004
    Very virulent (vv) infectious bursal disease virus (IBDV) Gx strain with high pathogenicity was attenuated through replication in specific-pathogen-free (SPF) chicken embryos and in chicken embryo fibroblast (CEF) cell cultures...
  40. pmc Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B
    Chung Chau Hon
    Department of Zoology, The University of Hong Kong, China
    J Virol 80:8503-9. 2006
    b>Infectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease...
  41. ncbi Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa
    Ibrahim Eldaghayes
    Institute for Animal Health, Compton, Berkshire, United Kingdom
    Viral Immunol 19:83-91. 2006
    Little is understood about the immune responses involved in the pathogenesis of infectious bursal disease virus (IBDV)...
  42. ncbi Proteomics analysis of host cells infected with infectious bursal disease virus
    Xiaojuan Zheng
    Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029, China
    Mol Cell Proteomics 7:612-25. 2008
    The effect of infectious bursal disease virus (IBDV) infection on cellular protein expression is essential for viral pathogenesis...
  43. ncbi Role of intrabursal T cells in infectious bursal disease virus (IBDV) infection: T cells promote viral clearance but delay follicular recovery
    S Rautenschlein
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota, USA
    Arch Virol 147:285-304. 2002
    b>Infectious bursal disease virus (IBDV) induces an acute, highly contagious immunosuppressive disease in young chickens. We examined the role of T cells in IBDV-induced immunopathogenesis and tissue recovery...
  44. ncbi Infectious bursal disease virus, a non-enveloped virus, possesses a capsid-associated peptide that deforms and perforates biological membranes
    Marie Galloux
    Unite de Virologie et Immunologie Moleculaires, UR892, Batiment de Biotechnologies, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78350 Jouy en Josas, France
    J Biol Chem 282:20774-84. 2007
    ..We hereby report how infectious bursal disease virus, an avian birnavirus, can disrupt cell membranes and enter into its target cells...
  45. ncbi The C-terminal domain of the pVP2 precursor is essential for the interaction between VP2 and VP3, the capsid polypeptides of infectious bursal disease virus
    Ana Oña
    Department of Biología Molecular y Celular, Centro Nacional de Biotecnologia, Cantoblanco, 28049 Madrid, Spain
    Virology 322:135-42. 2004
    The interaction between the infectious bursal disease virus (IBDV) capsid proteins VP2 and VP3 has been analyzed in vivo using baculovirus expression vectors...
  46. ncbi An improved method for infectious bursal disease virus rescue using RNA polymerase II system
    Xiaole Qi
    Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    J Virol Methods 142:81-8. 2007
    ..In this study, we developed a method to rescue infectious bursal disease virus (IBDV) using RNA polymerase II...
  47. pmc Nonstructural protein of infectious bursal disease virus inhibits apoptosis at the early stage of virus infection
    Meihong Liu
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    J Virol 80:3369-77. 2006
    b>Infectious bursal disease virus (IBDV), the causative agent of a highly contagious disease in chickens, carries a small nonstructural protein (NS). This protein has been implicated to play a role in the induction of apoptosis...
  48. ncbi Confirmation of the existence of two distinct genetic groups of infectious bursal disease virus in Australia
    J Ignjatovic
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag No 24, Geelong, Victoria 3220
    Aust Vet J 80:689-94. 2002
    ..To characterise infectious bursal disease viruses (IBDVs) prevalent at major commercial sites throughout Australia and to compare the nucleic acid sequences of local strains of IBDV with those of characterised overseas strains...
  49. ncbi Large-scale manufacture and use of recombinant VP2 vaccine against infectious bursal disease in chickens
    Jun Rong
    College of Life Science Yangtze University, Jingzhou, Hubei 434025, PR China
    Vaccine 25:7900-8. 2007
    ..Correlation coefficient between the OD values of VP2-based ELISA and the virions-based ELISA was 0.782. The results will make it possible for the vaccine to be produced commercially and used in poultry industry in large scale...
  50. ncbi Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV
    Yong shan Wang
    Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China
    Vaccine 30:2125-30. 2012
    Current infectious bursal disease virus (IBDV) vaccines suffer from maternal antibody interference and mimotope vaccines might be an alternative...
  51. ncbi Molecular epidemiologic evidence of homologous recombination in infectious bursal disease viruses
    Daral J Jackwood
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Avian Dis 56:574-7. 2012
    Nucleotide and predicted amino acid sequences of the infectious bursal disease virus (IBDV) surface protein VP2 have been used to identify strains of the virus and place them into phylogenetic groups...
  52. ncbi Detection of infectious bursal disease virus isolates with unknown antigenic properties by reverse genetics
    Alan H Icard
    Poultry Diagnostic and Research Center, The University of Georgia, 953 College Station Road, Athens, GA 30602, USA
    Avian Dis 52:590-8. 2008
    b>Infectious bursal disease virus (IBDV) serotype 1 is the causative agent of a highly contagious immunosuppressive disease of young chickens. In the past, a number of antigenic, as well as pathogenic, subtypes have been described...
  53. ncbi Rapid and sensitive detection of infectious bursal disease virus by reverse transcription loop-mediated isothermal amplification combined with a lateral flow dipstick
    Su Ming Tsai
    Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, 250 Road Kuo Kuang, National Chung Hsing University, Taichung 402, Taiwan
    J Virol Methods 181:117-24. 2012
    ..RT-LAMP) combined with a chromatographic lateral flow dipstick (LFD) for the detection of infectious bursal disease virus (IBDV) was developed...
  54. pmc Autoproteolytic activity derived from the infectious bursal disease virus capsid protein
    Nerea Irigoyen
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas CSIC, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 284:8064-72. 2009
    ..Here we show that the precursor (pVP2) of the capsid protein VP2 of the infectious bursal disease virus (IBDV), an avian double-stranded RNA virus, has autoproteolytic activity...
  55. ncbi Effects of a multi-strain probiotic (PrimaLac) on performance and antibody responses to Newcastle disease virus and infectious bursal disease virus vaccination in broiler chickens
    A Talebi
    Poultry Diseases Division, Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
    Avian Pathol 37:509-12. 2008
    ....
  56. ncbi Immune response and resistance to infectious bursal disease virus of chicken lines selected for high or low antibody response to Escherichia coli
    J Pitcovski
    MIGAL, Kiryat Shmona, Rosh-Pinah, Israel
    Poult Sci 80:879-84. 2001
    ..of these lines to immunization with a commercial vaccine (whole inactivated virus, WIV) against infectious bursal disease virus (IBDV) or with proteins VP2 and VP3 of that virus, and their resistance to challenge with a virulent ..
  57. ncbi Development of a tailored vaccine against challenge with very virulent infectious bursal disease virus of chickens using reverse genetics
    Li Gao
    Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, PR China
    Vaccine 29:5550-7. 2011
    Due to the problems associated with traditional methods for infectious bursal disease virus (IBDV) vaccine development and the pressure of evolution and variation of very virulent strains, it is urgent to develop IBDV vaccine rapidly ..
  58. ncbi Efficient rescue of infectious bursal disease virus from cloned cDNA: evidence for involvement of the 3'-terminal sequence in genome replication
    H J Boot
    Department of Avian Virology, Institute for Animal Science and Health, Lelystad, The Netherlands
    Virology 265:330-41. 1999
    To study the mechanism of replication of infectious bursal disease virus (IBDV), and to determine factors on the IBDV RNA which are involved in viral replication, we used cloned full-length cDNA of both the A- and B-segments to generate ..
  59. ncbi Assessment of genetic, antigenic and pathotypic criteria for the characterization of IBDV strains
    T P van den Berg
    Avian Virology and Immunology Unit, Veterinary and Agrochemical Research centre Groeselenberg 99 1180 Brussels, Belgium
    Avian Pathol 33:470-6. 2004
    The aim of this work was the selection and comparison of representative infectious bursal disease virus (IBDV) strains...
  60. ncbi Comparative immunopathogenesis of mild, intermediate, and virulent strains of classic infectious bursal disease virus
    Silke Rautenschlein
    Klinik fur Geflugel, Tierarztliche Hochschule Hannover, Bunteweg 17, 30559 Hannover, Germany
    Avian Dis 47:66-78. 2003
    Differences in the immunopathogenesis of several strains of infectious bursal disease virus (IBDV) were compared...
  61. ncbi Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). II. Antigenicity at the epitope level
    Isaac R Rodriguez-Chavez
    Department of Animal and Food Sciences, Allen Biotechnology Laboratory, University of Delaware, 601 Sincock Lane, Newark, DE 19717, USA
    Avian Pathol 31:473-83. 2002
    Antigenic variation of infectious bursal disease virus (IBDV) due to propagation in different host systems (bursa of Fabricius, embryos, or cell cultures) was determined by enzyme-linked immunosorbent assay (indirect and antigen capture) ..
  62. pmc A second form of infectious bursal disease virus-associated tubule contains VP4
    H Granzow
    Institutes of Diagnostic Virology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Insel Riems, Germany
    J Virol 71:8879-85. 1997
    Preparations of density gradient-purified infectious bursal disease virus (IBDV) were found to contain full and empty icosahedral virions, type I tubules with a diameter of about 60 nm, and type II tubules 24 to 26 nm in diameter...
  63. ncbi Infectious bursal disease virus activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of PI3K
    Li Wei
    Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No 9 Shuguang Garden Middle Road, Haidian District, Beijing 100097, People s Republic of China
    Virology 417:211-20. 2011
    ..The present study demonstrated for the first time that infectious bursal disease virus (IBDV), the causative agent of a highly contagious disease in chickens, can induce Akt ..
  64. ncbi High sequence diversity in infectious bursal disease virus serotype 1 in poultry and turkey suggests West-African origin of very virulent strains
    A A Owoade
    Department of Immunology, Laboratoire National de Santé, Luxembourg
    Arch Virol 149:653-72. 2004
    Fifty-eight outbreaks of Infectious bursal disease virus (IBDV) were observed in vaccinated chicken flocks in four Southwestern states of Nigeria between 1995 and 2000...
  65. ncbi VP5-deficient mutant virus induced protection against challenge with very virulent infectious bursal disease virus of chickens
    Liting Qin
    Division of Avian Infectious Diseases, National State Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, 427 Maduan Street, Nangang District, Harbin 150001, PR China
    Vaccine 28:3735-40. 2010
    A mutant infectious bursal disease virus (IBDV) deficient in expressing VP5, rGx-F9VP2DeltaVP5, was generated using reverse genetics technology...
  66. ncbi Protection against infectious bursal disease virulent challenge conferred by a recombinant avian adeno-associated virus vaccine
    F Perozo
    Poultry Diagnostic and Research Center, University of Georgia, Athens, GA 30602, USA
    Avian Dis 52:315-9. 2008
    ..In this experiment, an avian adeno-associated virus (AAAV) expressing the infectious bursal disease virus (IBDV) VP2 protein (rAAAV-VP2) was evaluated for protection against IBDV-virulent challenge...
  67. ncbi Induction of protective immunity in chickens immunized with plant-made chimeric Bamboo mosaic virus particles expressing very virulent Infectious bursal disease virus antigen
    Tsung Hsien Chen
    Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan, ROC
    Virus Res 166:109-15. 2012
    Very virulent Infectious bursal disease virus (vvIBDV) causes a highly contagious disease in young chickens and leads to significant economic loss in the poultry industry. Effective new vaccines are urgently needed...
  68. ncbi Infectious bursal disease subunit vaccination
    Pedro Villegas
    Poultry Diagnostic and Research Center, University of Georgia, Athens, GA 30602, USA
    Avian Dis 52:670-4. 2008
    b>Infectious bursal disease virus (IBDV) is the causative agent of infectious bursal disease, a nosologic entity with global economic importance in poultry. The viral protein 2 (VP2) is recognized as the virus' major antigenic protein...
  69. ncbi Conjugated linoleic acids alleviate infectious bursal disease virus-induced immunosuppression in broiler chickens
    F Y Long
    The State Key Lab of Animal Nutrition, College of Animal Science and Technology, China Agriculture University, Beijing, 100193, PR China
    Poult Sci 90:1926-33. 2011
    ..CLA ameliorates immunosuppression, we developed a viral challenge model by infecting chickens with infectious bursal disease virus (IBDV)...
  70. ncbi Development of a disperse dye immunochromatographic test for the detection of antibodies against infectious bursal disease virus
    Shwu Jinng Wang
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Vet Immunol Immunopathol 125:284-90. 2008
    ..marker, a disperse dye, DADISPERSE NAVY BLUE SP, was selected in analyzing antibody against infectious bursal disease virus (anti-IBDV)...
  71. pmc VP5 of infectious bursal disease virus is not essential for viral replication in cell culture
    E Mundt
    Institutes of Molecular and Cellular Virology, Friedrich Loeffler Institutes, Federal Research Center for Virus Diseases of Animals, Insel Riems, Germany
    J Virol 71:5647-51. 1997
    b>Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, encodes in its bisegmented double-stranded RNA genome four structural virion proteins, VP1, VP2, VP3, and VP4, as well as a nonstructural protein, VP5...
  72. pmc Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via interaction with VP5
    Zhonghua Li
    State Key Laboratory of Agrobiotechnology, Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, and College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 86:1328-38. 2012
    ..Thus, VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death...
  73. ncbi Infectious bursal disease virus (IBDV) induces apoptosis in chicken B cells
    Juan Carlos Rodriguez-Lecompte
    Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada C1A 4P3
    Comp Immunol Microbiol Infect Dis 28:321-37. 2005
    The ability of infectious bursal disease virus (IBDV) serotypes 1 and 2, and the role of VP4 of both serotypes as well as the capacity of three IBDV intermediate serotype 1-specific vaccine strains to induce apoptosis in a chicken B-..
  74. ncbi Immunization of chickens with VP2 protein of infectious bursal disease virus expressed in Arabidopsis thaliana
    H Wu
    Department of Poultry Science, Auburn University, Auburn, AL 36849, USA
    Avian Dis 48:663-8. 2004
    ..Chickens immunized with a commercial vaccine at 1 and 3 wk showed 78% protection. Results supported the efficacy of plant-produced VP2 as a vaccine against IBD...
  75. ncbi DNA vaccination with VP2 gene of very virulent infectious bursal disease virus (vvIBDV) delivered by transgenic E. coli DH5alpha given orally confers protective immune responses in chickens
    M S Mahmood
    Department of Veterinary Microbiology, University of Agriculture, Faisalabad 38040, Pakistan
    Vaccine 25:7629-35. 2007
    ....
  76. ncbi Differences in genetic background influence the induction of innate and acquired immune responses in chickens depending on the virulence of the infecting infectious bursal disease virus (IBDV) strain
    Merve Aricibasi
    Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, Germany
    Vet Immunol Immunopathol 135:79-92. 2010
    Previous studies and field observations have suggested that genetic background influences infectious bursal disease virus (IBDV) pathogenesis...
  77. ncbi Molecular and antigenic characterization of Bangladeshi isolates of infectious bursal disease virus demonstrate their similarities with recent European, Asian and African very virulent strains
    M R Islam
    Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Germany
    J Vet Med B Infect Dis Vet Public Health 48:211-21. 2001
    Three isolates of infectious bursal disease virus (IBDV), obtained from chickens in Bangladesh in 1999 and designated as BD 1/99, BD 2/99 and BD 3/99, were characterized...
  78. ncbi Development and large-scale use of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens
    Jacob Pitcovski
    MIGAL, South Industrial Area, P O Box 831, Kiryat Shmona 11016, Israel
    Vaccine 21:4736-43. 2003
    b>Infectious bursal disease virus (IBDV) is the causative agent of Gumboro disease, an infectious disease of global economic importance in poultry...
  79. ncbi Effects of early age feed restriction and heat conditioning on heat shock protein 70 expression, resistance to infectious bursal disease, and growth in male broiler chickens subjected to heat stress
    P K Liew
    Department of Animal Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Poult Sci 82:1879-85. 2003
    ..We concluded that FRHT could improve weight gain and resistance to IBD in male broiler chickens under heat stress conditions. The improved heat tolerance and disease resistance in FRHT birds could be attributed to better HSP 70 response...
  80. ncbi Effects of chicken anemia virus and infectious bursal disease virus in commercial chickens
    H Toro
    Department of Pathobiology, College of Veterinary Medicine, 264 Greene Hall, Auburn University, AL 36849 5519, USA
    Avian Dis 53:94-102. 2009
    The effects of chicken anemia virus (CAV) and infectious bursal disease virus (IBDV) coinfection in commercial layer-type and meat-type (broiler) chickens with specific maternal immunity were evaluated...
  81. ncbi Enhancement of the immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with plasmid encoding chicken interleukin 2
    Jianrong Li
    Institute of Preventive Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310029, PR China
    Virology 329:89-100. 2004
    ..interleukin 2 (IL-2), chicken IL-2 (chIL-2), was investigated using a DNA vaccine against infectious bursal disease virus (IBDV) as a model...
  82. ncbi Apoptosis is induced by infectious bursal disease virus replication in productively infected cells as well as in antigen-negative cells in their vicinity
    A Jungmann
    , , , An den Tierkliniken 29, D-04103 Leipzig, Germany
    J Gen Virol 82:1107-15. 2001
    The kinetics of infectious bursal disease virus (IBDV) replication and induction of apoptosis were investigated in vitro and in vivo...
  83. ncbi Infectious bursal disease virus-induced immunosuppression exacerbates Campylobacter jejuni colonization and shedding in chickens
    Kathryn A Subler
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Avian Dis 50:179-84. 2006
    ..b>Infectious bursal disease virus (IBDV) causes an immunosuppressive disease in young chickens...
  84. pmc Detection of vvIBDV in vaccinated SPF chickens
    S Kabell
    Danish Institute for Food and Veterinary Research, Hangøvej 2, DK 8200 Aarhus N Denmark
    Acta Vet Scand 46:219-27. 2005
    ..investigate, if apparently healthy, vaccinated chickens may be involved in maintaining and spreading infectious bursal disease virus (IBDV) in poultry environments...
  85. ncbi Infection and activation of bursal macrophages by virulent infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Virus Res 113:44-50. 2005
    In this study the effect of infectious bursal disease virus (IBDV) on bursal macrophages during the acute phase of the infection was examined...
  86. pmc Inactivation of infectious bursal disease virus by binary ethylenimine and formalin
    M Habib
    Department of Veterinary Microbiology, University of Agriculture, Faisalabad 38040, Pakistan
    J Zhejiang Univ Sci B 7:320-3. 2006
    In this experiment conducted to study the inactivation dynamics of infectious bursal disease virus (IBDV) by binary ethylenimine (BEI) in comparison with formalin, IBDV was isolated from the bursa of infected chickens and its ..
  87. ncbi Development of a multiplex PCR for detection of avian adenovirus, avian reovirus, infectious bursal disease virus, and chicken anemia virus
    Kristen M Caterina
    Department of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Road, Storrs, CT 06269 3089, USA
    Mol Cell Probes 18:293-8. 2004
    ..simultaneous detection and differentiation of avian reovirus (ARV), avian adenovirus group I (AAV-I), infectious bursal disease virus (IBDV), and chicken anemia virus (CAV)...
  88. ncbi Sequence analysis of the VP2 hypervariable region of eight very virulent infectious bursal disease virus isolates from the northeast of China
    Yanqing Yuwen
    Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    Avian Dis 52:284-90. 2008
    ..The other isolates were similar to the UK661 strain. Our findings demonstrated that the vvlBDV strains in the northeast of China could be diverse...
  89. ncbi Evidence for functional significance of the permuted C motif in Co2+-stimulated RNA-dependent RNA polymerase of infectious bursal disease virus
    Tobias Letzel
    Institute of Molecular Biology, Friedrich Loeffler Institut, 17493 Greifswald Insel Riems, Germany
    J Gen Virol 88:2824-33. 2007
    Segment B of bisegmented infectious bursal disease virus (IBDV) encodes virus protein 1 (VP1), possessing RNA-dependent RNA polymerase (RdRp) activity...
  90. ncbi A comparison of immune responses to infection with virulent infectious bursal disease virus (IBDV) between specific-pathogen-free chickens infected at 12 and 28 days of age
    Silke Rautenschlein
    Clinic for Poultry, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Vet Immunol Immunopathol 115:251-60. 2007
    Previous studies indicated that the pathogenesis of infectious bursal disease virus (IBDV) may vary depending on the age of the infected chicken...
  91. ncbi Genetic reassortment of infectious bursal disease virus in nature
    Yongwei Wei
    Institute of Preventive Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou 310029, PR China
    Biochem Biophys Res Commun 350:277-87. 2006
    b>Infectious bursal disease virus (IBDV), a double-stranded RNA virus, is a member of the Birnaviridae family. Four pathotypes of IBDV, attenuated, virulent, antigenic variant, and very virulent (vvIBDV), have been identified...
  92. ncbi Reassortant infectious bursal disease virus isolated in China
    Yongwei Wei
    Institute of Preventive Veterinary Medicine, College of Animal Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, PR China
    Virus Res 131:279-82. 2008
    b>Infectious bursal disease virus (IBDV) is a bi-segmented, double-stranded RNA virus which belongs to the genus Avibirnavirus of the family Birnavirideae...
  93. ncbi In vivo activation of chicken macrophages by infectious bursal disease virus
    J M Palmquist
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA
    Viral Immunol 19:305-15. 2006
    b>Infectious bursal disease virus (IBDV) infects and replicates in the dividing B lymphocytes of chickens. In the present study, the in vivo effect of IBDV infection on chicken macrophage populations and macrophage activation were examined...
  94. ncbi Adaptation of a mallard H5N2 low pathogenicity influenza virus in chickens with prior history of infection with infectious bursal disease virus
    Gloria Ramirez-Nieto
    Department of Veterinary Medicine, University of Maryland, College Park 20742 3711, USA
    Avian Dis 54:513-21. 2010
    ..had been previously infected at 2 days of age with, and recovered from, the immunosuppressive agent infectious bursal disease virus (IBDV; herein referred to as IBDV chickens)...
  95. ncbi Expression of perforin-granzyme pathway genes in the bursa of infectious bursal disease virus-infected chickens
    Abdul Rauf
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, United States
    Dev Comp Immunol 35:620-7. 2011
    ..The findings of this study highlight the mechanisms of IBD pathogenesis and the role of cytotoxic T cells in the clearance of virus-infected cells...
  96. ncbi Relative quantification and detection of different types of infectious bursal disease virus in bursa of Fabricius and cloacal swabs using real time RT-PCR SYBR green technology
    Y P Li
    Department of Poultry, Fish and Fur Animals, Danish Institute for Food and Veterinary Research, Hangøvej 2, DK 8200 Aarhus N, Denmark
    Res Vet Sci 82:126-33. 2007
    In present study, different types of infectious bursal disease virus (IBDV), virulent strain DK01, classic strain F52/70 and vaccine strain D78 were quantified and detected in infected bursa of Fabricius (BF) and cloacal swabs using ..
  97. ncbi Effect of sulfated astragalus polysaccharide on cellular infectivity of infectious bursal disease virus
    Xiaoyan Huang
    Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Int J Biol Macromol 42:166-71. 2008
    ....
  98. ncbi Effect of a variant infectious bursal disease virus (E/Del) on Salmonella typhimurium infection in commercial broiler chickens
    D A Bautista
    Virginia Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, University of Maryland, College Park, MD 20742 3711, USA
    Avian Dis 48:361-9. 2004
    The effect of infectious bursal disease virus (IBDV) on Salmonella typhimurium (ST) infections in broilers was investigated in terms of Salmonella shedding and persistence, pathogenicity, and isotype specific humoral immune responses...
  99. pmc VP1, the putative RNA-dependent RNA polymerase of infectious bursal disease virus, forms complexes with the capsid protein VP3, leading to efficient encapsidation into virus-like particles
    E Lombardo
    , , Cantoblanco, 28049 Madrid, Spain
    J Virol 73:6973-83. 1999
    A cDNA corresponding to the coding region of VP1, the putative RNA-dependent RNA polymerase, of infectious bursal disease virus (IBDV) was cloned and inserted into the genome of a vaccinia virus inducible expression vector...
  100. ncbi Induction of apoptosis in vitro by the 17-kDa nonstructural protein of infectious bursal disease virus: possible role in viral pathogenesis
    K Yao
    Center for Agricultural Biotechnology, University of Maryland, College Park, Maryland 20742, USA
    Virology 285:50-8. 2001
    b>Infectious bursal disease virus (IBDV) causes severe immunodeficiency in young chickens by destroying the precursors of antibody-producing B cells in the bursa of Fabricius...
  101. pmc Modifications of the 3'-UTR stem-loop of infectious bursal disease virus are allowed without influencing replication or virulence
    Hein J Boot
    Animal Sciences Group, Wageningen University and Research Centre, Lelystad, The Netherlands
    Nucleic Acids Res 32:211-22. 2004
    ..the initiation of replication and translation of the segmented, double-stranded RNA genome of infectious bursal disease virus (IBDV) remain to be solved...

Research Grants1

  1. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward H Egelman; Fiscal Year: 2012
    ..The proposed focus is on capsid proteins from bacteriophage P22, Infectious Bursal Disease Virus, and Murine Leukemia virus...