human respiratory syncytial virus

Summary

Summary: The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

Top Publications

  1. pmc Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene
    S Techaarpornkul
    Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA
    J Virol 75:6825-34. 2001
  2. ncbi Respiratory syncytial virus with the fusion protein as its only viral glycoprotein is less dependent on cellular glycosaminoglycans for attachment than complete virus
    Sunee Techaarpornkul
    Department of Biopharmacy, Silpakorn University, Sanamchan Palace Campus, Nakornpathom, 73000, Thailand
    Virology 294:296-304. 2002
  3. ncbi Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
    Malcolm G Semple
    Department of Child Health, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:382-6. 2005
  4. pmc Respiratory syncytial virus infection in adults
    A R Falsey
    Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    Clin Microbiol Rev 13:371-84. 2000
  5. pmc Subgroup prevalence and genotype circulation patterns of human respiratory syncytial virus in Belgium during ten successive epidemic seasons
    Kalina T Zlateva
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Clin Microbiol 45:3022-30. 2007
  6. ncbi Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Gen Virol 84:3115-20. 2003
  7. pmc Genetic variability and molecular evolution of the human respiratory syncytial virus subgroup B attachment G protein
    Kalina T Zlateva
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Virol 79:9157-67. 2005
  8. pmc Ten years of global evolution of the human respiratory syncytial virus BA genotype with a 60-nucleotide duplication in the G protein gene
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Virol 84:7500-12. 2010
  9. pmc Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G
    S A Feldman
    Laboratory of Pediatric and Respiratory Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 73:6610-7. 1999
  10. ncbi The histopathology of fatal untreated human respiratory syncytial virus infection
    Joyce E Johnson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Mod Pathol 20:108-19. 2007

Research Grants

Detail Information

Publications281 found, 100 shown here

  1. pmc Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene
    S Techaarpornkul
    Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA
    J Virol 75:6825-34. 2001
    ....
  2. ncbi Respiratory syncytial virus with the fusion protein as its only viral glycoprotein is less dependent on cellular glycosaminoglycans for attachment than complete virus
    Sunee Techaarpornkul
    Department of Biopharmacy, Silpakorn University, Sanamchan Palace Campus, Nakornpathom, 73000, Thailand
    Virology 294:296-304. 2002
    ..This alternative pathway presumably is mediated by the sole remaining viral surface protein, F, although the formal possibility exists that some other virion-associated protein is involved...
  3. ncbi Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
    Malcolm G Semple
    Department of Child Health, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:382-6. 2005
    The association between severe bronchiolitis and dual infection by human metapneumovirus (hMPV) and human respiratory syncytial virus (hRSV) was investigated in <2-year-old infants with bronchiolitis who were admitted to the hospital ..
  4. pmc Respiratory syncytial virus infection in adults
    A R Falsey
    Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    Clin Microbiol Rev 13:371-84. 2000
    ..An effective RSV vaccine has not yet been developed, and thus prevention of RSV infection is limited to standard infection control practices such as hand washing and the use of gowns and gloves...
  5. pmc Subgroup prevalence and genotype circulation patterns of human respiratory syncytial virus in Belgium during ten successive epidemic seasons
    Kalina T Zlateva
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Clin Microbiol 45:3022-30. 2007
    b>Human respiratory syncytial virus (HRSV) is the leading viral cause of severe respiratory illness for infants and young children worldwide...
  6. ncbi Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Gen Virol 84:3115-20. 2003
    The entire nucleotide sequence of the G gene of three human respiratory syncytial virus (HRSV) isolates (antigenic group B) has been determined...
  7. pmc Genetic variability and molecular evolution of the human respiratory syncytial virus subgroup B attachment G protein
    Kalina T Zlateva
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Virol 79:9157-67. 2005
    b>Human respiratory syncytial virus (HRSV) is the most important cause of acute respiratory disease in infants. Two major subgroups (A and B) have been identified based on antigenic differences in the attachment G protein...
  8. pmc Ten years of global evolution of the human respiratory syncytial virus BA genotype with a 60-nucleotide duplication in the G protein gene
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Virol 84:7500-12. 2010
    The emergence of natural isolates of human respiratory syncytial virus group B (HRSV-B) with a 60-nucleotide (nt) duplication in the G protein gene in Buenos Aires, Argentina, in 1999 (A. Trento et al., J. Gen. Virol...
  9. pmc Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G
    S A Feldman
    Laboratory of Pediatric and Respiratory Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 73:6610-7. 1999
    ..These results indicate that the sequence 184A/183K-->198T/K197 for RSV subgroups A and B, respectively, defines an important determinant of RSV-G interactions with heparin...
  10. ncbi The histopathology of fatal untreated human respiratory syncytial virus infection
    Joyce E Johnson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Mod Pathol 20:108-19. 2007
    ..These findings inform our understanding of RSV pathogenesis and may facilitate the development of new approaches for prevention and treatment...
  11. pmc Human respiratory syncytial virus A2 strain replicates and induces innate immune responses by respiratory epithelia of neonatal lambs
    Alicia Olivier
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Int J Exp Pathol 90:431-8. 2009
    b>Human respiratory syncytial virus (hRSV) is a pneumovirus that causes significant respiratory disease in premature and full-term infants...
  12. ncbi Respiratory syncytial virus epidemics: the ups and downs of a seasonal virus
    Lone Graff Stensballe
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Copenhagen, Denmark
    Pediatr Infect Dis J 22:S21-32. 2003
    ..Generally RSV mortality is low, with a median value of zero. However, RSV mortality in developing countries is significantly higher than RSV mortality in developed countries...
  13. ncbi Palivizumab-resistant human respiratory syncytial virus infection in infancy
    Ortwin Adams
    Institute of Virology, University Children s Hospital, Heinrich Heine University, Dusseldorf, Germany
    Clin Infect Dis 51:185-8. 2010
    ..A stable mutation at codon 276 led to a nearly complete resistance to palivizumab. Additional studies revealed a second mutation at codon 272. Further passage of the virus led to a complete loss of binding of palivizumab...
  14. pmc The fusion glycoprotein of human respiratory syncytial virus facilitates virus attachment and infectivity via an interaction with cellular heparan sulfate
    S A Feldman
    Laboratory of Pediatric and Respiratory Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20852 1448, USA
    J Virol 74:6442-7. 2000
    b>Human respiratory syncytial virus (RSV) F glycoprotein (RSV-F) can independently interact with immobilized heparin and facilitate both attachment to and infection of cells via an interaction with cellular heparan sulfate...
  15. pmc Emerging genotypes of human respiratory syncytial virus subgroup A among patients in Japan
    Yugo Shobugawa
    Department of Infectious Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata City, Japan
    J Clin Microbiol 47:2475-82. 2009
    b>Human respiratory syncytial virus (HRSV) is a common etiological agent of acute lower respiratory tract disease in infants...
  16. pmc Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007
    Janine Reiche
    FG12 Virale Infektionen, NRZ Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Microbiol 47:1800-10. 2009
    ..This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons...
  17. pmc Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines
    Kirsten M Spann
    Laboratory of Infectious Diseases, NIAID, Building 50, Room 6503, 50 South Dr, MSC 8007, Bethesda, MD 20892 8007, USA
    J Virol 79:5353-62. 2005
    b>Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives...
  18. ncbi Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life
    D James Nokes
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    J Infect Dis 190:1828-32. 2004
    ..RSV contributed significantly to total LRTI disease in this vaccine-target group...
  19. pmc Molecular evolution and circulation patterns of human respiratory syncytial virus subgroup a: positively selected sites in the attachment g glycoprotein
    Kalina T Zlateva
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    J Virol 78:4675-83. 2004
    b>Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life...
  20. ncbi Heparin-dependent attachment of respiratory syncytial virus (RSV) to host cells
    T Krusat
    Department of Medical Microbiology and Virology, Ruhr University, Bochum, Germany
    Arch Virol 142:1247-54. 1997
    ..Therefore heparin-like proteoglycans showed properties required for attachment of RSV to host cells...
  21. ncbi Respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo
    Allison L Miller
    University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan 48109, USA
    J Infect Dis 189:1419-30. 2004
    ..Our results suggest that viral replication is necessary for optimal chemokine production...
  22. pmc Human respiratory syncytial virus glycoproteins are not required for apical targeting and release from polarized epithelial cells
    Melissa Batonick
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908 0904, USA
    J Virol 82:8664-72. 2008
    b>Human respiratory syncytial virus (HRSV) is released from the apical membrane of polarized epithelial cells...
  23. pmc Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein
    Margarita Magro
    Laboratorio de Biología Viral, Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Virol 84:7970-82. 2010
    b>Human respiratory syncytial virus (HRSV) fusion (F) protein is an essential component of the virus envelope that mediates fusion of the viral and cell membranes, and, therefore, it is an attractive target for drug and vaccine development...
  24. ncbi Bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 368:312-22. 2006
    ..Careful mapping of the inflammatory pathways in the pathogenesis of bronchiolitis should lead to development of new therapies to alleviate symptoms...
  25. ncbi Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion
    Enxiu Wang
    Department of Molecular Virology and Bio Engineering, Institute of Microbiology, Chinese Academy of Sciences, Zhongguancun Beiyitiao, Beijing 100080, China
    Biochem Biophys Res Commun 302:469-75. 2003
    ..However, in other members, only HR2 gives strong inhibition whereas HR1 does not. Human respiratory syncytial virus (hRSV) is a member of paramyxovirus and its crystal structure of HR1 and HR2 six-helix bundle was ..
  26. pmc Infection and maturation of monocyte-derived human dendritic cells by human respiratory syncytial virus, human metapneumovirus, and human parainfluenza virus type 3
    Cyril Le Nouen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 385:169-82. 2009
    b>Human respiratory syncytial virus (HRSV), human metapneumovirus (HMPV), and human parainfluenza virus type 3 (HPIV3) are common, important respiratory pathogens, but HRSV has a substantially greater impact with regard to acute disease, ..
  27. ncbi Design and characterization of human respiratory syncytial virus entry inhibitors
    Ling Ni
    Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Antivir Ther 10:833-40. 2005
    b>Human respiratory syncytial virus (hRSV) is a pathogen of worldwide health concern...
  28. pmc Respiratory syncytial virus vaccine development
    Yoshihiko Murata
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Lab Med 29:725-39. 2009
    ..The scientific rationale, preclinical testing, and clinical development of each of these approaches are reviewed...
  29. ncbi Structural properties of the human respiratory syncytial virus P protein: evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors
    María T Llorente
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    Proteins 72:946-58. 2008
    The oligomeric state and the hydrodynamic properties of human respiratory syncytial virus (HRSV) phosphoprotein (P), a known cofactor of the viral RNA-dependent RNA polymerase (L), and a trypsin-resistant fragment (X) that includes its ..
  30. ncbi Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanism
    M Begoña Ruiz-Argüello
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Gen Virol 85:3677-87. 2004
    Anchorless fusion (F) proteins () of human respiratory syncytial virus (RSV) are seen by electron microscopy as unaggregated cones when the proteolytic cleavage at two furin sites required for membrane-fusion activity is incomplete, but ..
  31. ncbi Unravelling the complexities of respiratory syncytial virus RNA synthesis
    Vanessa M Cowton
    Division of Pathology and Neuroscience, University of Dundee Medical School, Dundee DD1 9SY, UK
    J Gen Virol 87:1805-21. 2006
    b>Human respiratory syncytial virus (RSV) is the leading cause of paediatric respiratory disease and is the focus of antiviral- and vaccine-development programmes...
  32. pmc Evaluation of the Hexaplex assay for detection of respiratory viruses in children
    S C Kehl
    Department of Pathology, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Microbiol 39:1696-701. 2001
    ..4, 100, 100, and 83.3% for EIA; and 95.8, 98.7, 92.0, and 99.3% for Hexaplex. Hexaplex is a rapid, sensitive, and specific method for the detection of the seven most common respiratory viruses in children...
  33. ncbi Variations in transcription termination signals of human respiratory syncytial virus clinical isolates affect gene expression
    Robin M Moudy
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Virology 313:250-60. 2003
    b>Human respiratory syncytial virus (HRSV) has a single-stranded, negative-sense RNA genome with 10 genes encoding 11 proteins...
  34. pmc Genetic recombination during coinfection of two mutants of human respiratory syncytial virus
    Kirsten M Spann
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 8007, USA
    J Virol 77:11201-11. 2003
    ..However, the isolation of only a single rec-RSV under these optimized conditions supports the idea that RSV recombination is rare indeed...
  35. ncbi Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons
    Rodica Gilca
    Laval University, Quebec, Canada
    J Infect Dis 193:54-8. 2006
    Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children &..
  36. pmc A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats
    Myra N Widjojoatmodjo
    Laboratory of Vaccine Research, Netherlands Vaccine Institute, Bilthoven, The Netherlands
    Virol J 7:114. 2010
    ..Using reverse genetics, recombinant (r)RSV and an rRSV lacking the G gene (DeltaG) were constructed based on a clinical RSV isolate (strain 98-25147-X)...
  37. ncbi Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity
    Imene Fodha
    Research Unit UR06SP20, Laboratory of bacteriology virology, University Hospital Sahloul, Sousse, Tunisia
    J Med Virol 79:1951-8. 2007
    ..Analysis also showed that disease severity was not associated significantly with RSV subgroup. Thus, RSV disease severity is likely to be determined by an interplay between host and virus factors, including RSV load...
  38. pmc Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology
    Liqun Zhang
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    J Virol 76:5654-66. 2002
    ..Most gene transfer vectors so far tested have not provided the efficiency required. Although human respiratory syncytial virus (RSV), a common respiratory virus, is known to infect the respiratory epithelium, the mechanism of ..
  39. ncbi Human respiratory syncytial virus (hRSV) RNA quantification in nasopharyngeal secretions identifies the hRSV etiologic role in acute respiratory tract infections of hospitalized infants
    Giulia Campanini
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Virol 39:119-24. 2007
    b>Human respiratory syncytial virus (hRSV) detection in nasopharyngeal aspirates (NPAs) from infants with acute respiratory tract infection (ARTI) does not prove the hRSV etiology of the current ARTI episode...
  40. ncbi Recombinant human respiratory syncytial virus (RSV) from cDNA and construction of subgroup A and B chimeric RSV
    H Jin
    Aviron, 297 North Bernardo Avenue, Mountain View, California, 94043, USA
    Virology 251:206-14. 1998
    Infectious human respiratory syncytial virus (RSV) was produced from a cDNA clone that contains 15,222 nucleotides of RSV genome derived from the A2 strain of subgroup A...
  41. pmc The cytoplasmic tail of the human respiratory syncytial virus F protein plays critical roles in cellular localization of the F protein and infectious progeny production
    Antonius G P Oomens
    Department of Pathology, University of Virginia, MR5 Building, P O Box 800904, Charlottesville, VA 22908 0904, USA
    J Virol 80:10465-77. 2006
    The importance of the F protein cytoplasmic tail (CT) for replication of human respiratory syncytial virus (HRSV) was examined by monitoring the behavior of viruses expressing F proteins with a modified COOH terminus...
  42. ncbi Isolation and characterisation of potential respiratory syncytial virus receptor(s) on epithelial cells
    Rajneesh Malhotra
    Respiratory and Inflammation CEDD, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
    Microbes Infect 5:123-33. 2003
    ..Recombinant annexin II binds to RSV G-protein, heparin and plasminogen and the binding is inhibited by a selectin antagonist, TBC1269. These findings indicate that inhibitors of annexin II could have potential in treating RSV infection...
  43. ncbi Variations in intergenic region sequences of Human respiratory syncytial virus clinical isolates: analysis of effects on transcriptional regulation
    Robin M Moudy
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Virology 327:121-33. 2004
    Sequences at the beginnings and ends of Human respiratory syncytial virus (HRSV) genes are necessary for efficient initiation and termination of transcription...
  44. ncbi Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001--a review
    Juan Arbiza
    Facultad de Ciencias, Universidad de la Republica, Igua 4225, Montevideo, Uruguay
    Mem Inst Oswaldo Cruz 100:221-30. 2005
    ....
  45. ncbi Transgenic apple expressing an antigenic protein of the human respiratory syncytial virus
    Joann M Lau
    Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
    J Plant Physiol 167:920-7. 2010
    A gene coding for the human respiratory syncytial virus (RSV)-F protein, driven by the constitutively expressed CaMV 35S promoter, was introduced into leaf tissues of apple, Malusxdomestica Borkh. cv...
  46. pmc The NS2 protein of human respiratory syncytial virus suppresses the cytotoxic T-cell response as a consequence of suppressing the type I interferon response
    Alexander Kotelkin
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8007, USA
    J Virol 80:5958-67. 2006
    The NS1 and NS2 proteins of human respiratory syncytial virus (HRSV) have been shown to antagonize the type I interferon (IFN) response, an effect subject to host range constraints...
  47. pmc Respiratory syncytial virus (RSV) fusion protein subunit F2, not attachment protein G, determines the specificity of RSV infection
    Jörg Schlender
    Max von Pettenkofer Institute and Gene Center, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    J Virol 77:4609-16. 2003
    b>Human respiratory syncytial virus (HRSV) and bovine RSV (BRSV) infect human beings and cattle in a species-specific manner. We have here analyzed the contribution of RSV envelope proteins to species-specific entry into cells...
  48. pmc N-glycans of F protein differentially affect fusion activity of human respiratory syncytial virus
    G Zimmer
    , , D-30559 Hannover, Germany
    J Virol 75:4744-51. 2001
    The human respiratory syncytial virus (Long strain) fusion protein contains six potential N-glycosylation sites: N27, N70, N116, N120, N126, and N500...
  49. pmc The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P
    Ralph A Tripp
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 77:6580-4. 2003
    ..These data suggest new approaches for treating some aspects of RSV disease...
  50. ncbi Antigenic and genetic variation in human respiratory syncytial virus
    Gail W Wertz
    Department of Microbiology, University of Alabama at Birmingham, USA
    Pediatr Infect Dis J 23:S19-24. 2004
    b>Human respiratory syncytial virus (HRSV) is a leading cause of serious pediatric respiratory disease worldwide. Natural infection provides only partial protection as repeat infections occur throughout life...
  51. pmc The baculovirus GP64 protein mediates highly stable infectivity of a human respiratory syncytial virus lacking its homologous transmembrane glycoproteins
    A G P Oomens
    University of Alabama School of Medicine, Birmingham, Alabama 35294, USA
    J Virol 78:124-35. 2004
    ..expressed in mammalian cells, as well as its capacity to functionally complement a mammalian virus, human respiratory syncytial virus (HRSV)...
  52. ncbi Human respiratory syncytial virus reduces the number of cells in S-phase and increases GADD153 expression in HEp-2 cells
    S Mohapatra
    Department of Molecular Medicine, Joy McCann Culverhouse Airway Disease Center, College of Medicine, University of South Florida, VA Hospital, Tampa, Florida, USA
    Acta Virol 53:207-11. 2009
    b>Human respiratory syncytial virus (HRSV) associated with bronchiolitis and asthma is known to replicate actively in ciliated epithelial cells. However, little is known about the influence of HRSV replication on the cell cycle...
  53. ncbi Characteristics of a respiratory syncytial virus persistently infected macrophage-like culture
    Rosa Elena Sarmiento
    Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
    Virus Res 84:45-58. 2002
    ..In addition, due to the wide array of cellular and humoral reagents in the mouse, studies on immunologic aspects of viral immunity are facilitated...
  54. pmc Multiple, non-conserved, internal viral ligands naturally presented by HLA-B27 in human respiratory syncytial virus-infected cells
    Susana Infantes
    Unidad de Protemica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Mol Cell Proteomics 9:1533-9. 2010
    ..The CTL response is critical for the clearance of human respiratory syncytial virus (HRSV) infection...
  55. ncbi Multiple glycosylated forms of the respiratory syncytial virus fusion protein are expressed in virus-infected cells
    Helen W McL Rixon
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 83:61-6. 2002
    ..Collectively, these data show that multiple F protein species are expressed in RSV-infected cells...
  56. ncbi Characterization of the interaction of the human respiratory syncytial virus phosphoprotein and nucleocapsid protein using the two-hybrid system
    M S Slack
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Virus Res 55:167-76. 1998
    The interaction between the human respiratory syncytial virus phosphoprotein (P) and nucleocapsid (N) protein has been investigated using the two hybrid system in yeast and in tissue culture cells...
  57. pmc Interaction between human respiratory syncytial virus (RSV) M2-1 and P proteins is required for reconstitution of M2-1-dependent RSV minigenome activity
    Stephen W Mason
    Biological Sciences Department, Boehringer Ingelheim Canada Ltd, Laval, Quebec, Canada
    J Virol 77:10670-6. 2003
    ..On the basis of these observations, it is possible that the interaction between RSV M2-1 and P proteins is important for viral replication...
  58. pmc Purification of human respiratory syncytial virus by ultracentrifugation in iodixanol density gradient
    E Gias
    The School of Clinical Medical Sciences, The Medical School, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Virol Methods 147:328-32. 2008
    ..Iodixanol was also found to be non-toxic to HeLa cells used in infectivity assay, eliminating the need of its downstream removal by dialysis...
  59. ncbi Epitope mapping of human respiratory syncytial virus 22K transcription antitermination factor: role of N-terminal sequences in protein folding
    Blanca García-Barreno
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Gen Virol 86:1103-7. 2005
    The reactivity of a panel of 12 monoclonal antibodies raised against the human respiratory syncytial virus 22 kDa (22K) protein was tested by Western blotting with a set of 22K deletion mutants...
  60. ncbi Human respiratory syncytial virus and other viral infections in infants receiving palivizumab
    Guy Boivin
    Research Center in Infectious Diseases, CHUQ CHUL, Quebec City, QC, Canada
    J Clin Virol 42:52-7. 2008
    Palivizumab is a humanized monoclonal antibody that prevents severe human respiratory syncytial virus (HRSV) infections.
  61. ncbi Intragroup antigenic diversity of human respiratory syncytial virus (group A) isolated in Argentina and Chile
    Monica C Galiano
    Laboratorio de Virología Clínica, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Hospital Universitario, Buenos Aires, Argentina
    J Med Virol 77:311-6. 2005
    The intragroup antigenic diversity of the G glycoprotein of 226 human respiratory syncytial virus (HRSV) strains isolated in Buenos Aires (Argentina) and Santiago (Chile) between 1995 and 2002 was evaluated by ELISA with a panel of 14 ..
  62. ncbi Immunological mechanisms of severe respiratory syncytial virus bronchiolitis
    Louis Bont
    Wilhelmina Children s Hospital, University Medical Center, POB 85090, 3508 AB Utrecht, The Netherlands
    Intensive Care Med 28:616-21. 2002
    ....
  63. ncbi Detection of human respiratory syncytial virus genotype specific antibody responses in infants
    A McGill
    School of Clinical Medical Sciences, The Medical School, Newcastle upon Tyne, United Kingdom
    J Med Virol 74:492-8. 2004
    Infection and reinfection of infants with human respiratory syncytial virus (HRSV) occur despite the presence of serum anti-viral glycoprotein antibodies similar to those, which afford protection in animal models of infection...
  64. ncbi Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein
    J J Gorman
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 276:38988-94. 2001
    ..nonglycosylated central subdomain, residues 149-197, of the attachment (G) glycoprotein of human respiratory syncytial virus (HRSV) have been assessed for impact on the cytopathic effect (CPE) of respiratory syncytial virus (..
  65. ncbi Genetic variability in the G protein gene of human respiratory syncytial virus isolated from the Campinas metropolitan region, Brazil
    Luciana Helena Antoniassi da Silva
    Faculdade de Ciencias Medicas, Programa Pós Graduação, Clinica Medica, Universidade Estadual de Campinas UNICAMP, Campinas, Brazil
    J Med Virol 80:1653-60. 2008
    b>Human respiratory syncytial virus (hRSV) is recognized as the most important viral agent of serious respiratory tract diseases in the pediatric population worldwide...
  66. pmc Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity
    David R McGivern
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    J Virol 79:2449-60. 2005
    ....
  67. pmc The central conserved cystine noose of the attachment G protein of human respiratory syncytial virus is not required for efficient viral infection in vitro or in vivo
    Michael N Teng
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 8007, USA
    J Virol 76:6164-71. 2002
    The G glycoprotein of human respiratory syncytial virus (RSV) was identified previously as the viral attachment protein...
  68. ncbi Intracellular localization of human respiratory syncytial virus L protein
    C Carromeu
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Arch Virol 152:2259-63. 2007
    Replication and transcription of the human respiratory syncytial virus (hRSV) genome is carried out by the ribonucleocapsid complex (RNA together with N, P, M2-1 and L proteins), with the L protein being responsible for all enzymatic ..
  69. ncbi Distinct gene subsets are induced at different time points after human respiratory syncytial virus infection of A549 cells
    Isidoro Martinez
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    J Gen Virol 88:570-81. 2007
    ..was applied to time course analysis of differentially expressed genes in A549 cells following human respiratory syncytial virus (HRSV) infection...
  70. ncbi Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants
    John P DeVincenzo
    University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
    J Infect Dis 190:975-8. 2004
    ..Palivizumab bound to all 371 RSV isolates able to be evaluated, including 25 from active-palivizumab recipients. The palivizumab epitope appears to be highly conserved, even in infants receiving prophylaxis with palivizumab...
  71. pmc Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells
    Birgit Bossert
    Max von Pettenkofer Institute and Gene Center, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    J Virol 76:4287-93. 2002
    ..The differential IFN escape capacity of RSV NS proteins in cells from different hosts provides a basis for rational development of attenuated live RSV vaccines...
  72. ncbi Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Allergy Clin Immunol 116:550-7. 2005
    ....
  73. ncbi Respiratory syncytial virus infection in adults
    Ann R Falsey
    Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, Rochester, New York 14621, USA
    Semin Respir Crit Care Med 28:171-81. 2007
    ..Infection control measures are critical to limit spread of RSV. Currently, RSV vaccines are not available, but candidate vaccines are being developed...
  74. ncbi Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches
    Peter J Openshaw
    Department of Respiratory Medicine St Mary s, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Hospital, London W2 1PG, UK
    Pediatr Infect Dis J 22:S58-64; discussion S64-5. 2003
    ..Further study is necessary to determine the relative roles of RSV infection and genetic predisposition in explaining the association between RSV infection and asthma/RAD...
  75. ncbi Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection
    L K Hallak
    Immunology Microbiology, Biochemistry and Pathology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Virology 271:264-75. 2000
    ..Thus, the presence of cell surface GAGs containing iduronic acid, like heparan sulfate and chondroitin sulfate B, is required for efficient RSV infection in cell culture...
  76. pmc Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness
    Mindy S Lo
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 79:9315-9. 2005
    ..RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion...
  77. pmc Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I
    Zhenhua Ling
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, 406 Althouse, University Park, PA 16802, USA
    J Virol 83:3734-42. 2009
    ..For human respiratory syncytial virus (RSV), the nonstructural NS1 and NS2 proteins have been shown to block IFN signaling by causing the ..
  78. pmc Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]
    Kirsten M Spann
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8007, USA
    J Virol 78:4363-9. 2004
    Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta)...
  79. ncbi Determination of phosphorylated residues from human respiratory syncytial virus P protein that are dynamically dephosphorylated by cellular phosphatases: a possible role for serine 54
    Ana Asenjo
    Centro Nacional de Microbiología CNM, Instituto de Salud Carlos III ISCIII, Carretera Majadahonda Pozuelo Km 2, Majadahonda, E 28220 Madrid, Spain
    J Gen Virol 86:1109-20. 2005
    ..Nonetheless, dephosphorylation at S54 could facilitate P-M protein interactions that probably occur during the egress of viral particles...
  80. ncbi Factors predicting childhood respiratory syncytial virus severity: what they indicate about pathogenesis
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN, USA
    Pediatr Infect Dis J 24:S177-83, discussion S182. 2005
    ..Reviewing and interpreting the clinical risk factors to gain an insight into RSV pathogenesis is important, especially considering the relative lack of parallel between many animal models of RSV infection and observed human disease...
  81. pmc Genetic and antigenic variability of human respiratory syncytial virus (groups a and b) isolated over seven consecutive seasons in Argentina (1995 to 2001)
    Monica C Galiano
    Laboratorio de Virología Clínica, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Hospiatal Universitario, Buenos Aires, Argentina
    J Clin Microbiol 43:2266-73. 2005
    The genetic and antigenic variability of human respiratory syncytial virus (HRSV) strains isolated in Buenos Aires from 1995 to 2001 was evaluated by partial nucleotide sequencing of the G gene and enzyme-linked immunosorbent assay ..
  82. ncbi Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis
    Matti Korppi
    Department of Pediatrics, Kuopio University and University Hospital, Kuopio, Finland
    Pediatr Infect Dis J 23:995-9. 2004
    ..There is increasing evidence that rhinoviruses (RV) are able to cause lower airway infections and to induce wheezing in young children. There are few data on the clinical characteristics of RV infections in infants...
  83. ncbi Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997
    D K Shay
    Respiratory and Enteric Viruses Branch and National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 183:16-22. 2001
    ....
  84. ncbi Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1
    Zhenhua Ling
    Graduate Program in Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Protein Expr Purif 57:261-70. 2008
    ..The availability of purified RSV NS1 will permit biochemical and structural investigations providing insight into the function of NS1 in viral replication and interferon antagonism...
  85. pmc Identification of linear heparin-binding peptides derived from human respiratory syncytial virus fusion glycoprotein that inhibit infectivity
    Roberta L Crim
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 81:261-71. 2007
    It has been shown previously that the fusion glycoprotein of human respiratory syncytial virus (RSV-F) interacts with cellular heparan sulfate...
  86. pmc Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment
    J B Domachowske
    State University of New York Health Science Center at Syracuse, Syracuse, New York 13210
    Clin Microbiol Rev 12:298-309. 1999
    ..Although the treatment of RSV bronchiolitis is primarily supportive, the role of ribavirin is briefly discussed. Novel approaches to the development of new antiviral drugs with promising anti-RSV activity in vitro are also described...
  87. pmc Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain
    Siok Wan Gan
    School of Biological Sciences, Nanyang Technological University, 637551 Singapore
    Protein Sci 17:813-20. 2008
    The small hydrophobic (SH) protein from the human respiratory syncytial virus (hRSV) is a glycoprotein of approximately 64 amino acids with one putative alpha-helical transmembrane domain...
  88. pmc Timing of monoclonal antibody for seasonal RSV prophylaxis in the United Kingdom
    N L Goddard
    Health Protection Agency Centre for Infections, London, UK
    Epidemiol Infect 135:159-62. 2007
    ..Promptly commencing prophylaxis during the second week of each October (week 42) would precede the onset of the RSV season in the United Kingdom, and provide coverage until its decline in mid-March...
  89. pmc Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus
    Joost J Smit
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 203:1153-9. 2006
    ..It is demonstrated that plasmacytoid dendritic cells play a protective role during RSV infection by modulation of local immune responses...
  90. ncbi Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunity
    Caroline F Maher
    Respiratory Medicine, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Microbes Infect 6:1049-55. 2004
    ..Engineered RSV mutants lacking the ability to secrete G are thus promising vaccine candidates...
  91. ncbi Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free
    M G Semple
    Division of Child Health, School of Reproductive and Developmental Medicine, School of Infection and Host Defence, University of Liverpool, United Kingdom
    J Clin Virol 40:241-4. 2007
    ..Nasopharyngeal secretions aspirated from infants with bronchiolitis (NPA) are a valuable resource for the study of virus dynamics and local inflammatory responses, however samples are small and difficult to manipulate...
  92. ncbi Respiratory syncytial virus infections: recent prospects for control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 71:379-90. 2006
    ..In this review, updates on the status of the approved anti-RSV antibodies, ribavirin, and recent results of studies with potential new anti-RSV compounds are summarized and discussed...
  93. pmc Prospective study of human metapneumovirus infection in children less than 3 years of age
    Brigitte König
    Institute of Medical Microbiology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Clin Microbiol 42:4632-5. 2004
    ..Our data support the hypothesis that coinfections with RSV and hMPV are more severe than infections with either RSV or hMPV alone, at least in children younger than 3 years of age...
  94. ncbi Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection
    Hongwei Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London W2 1PG, United Kingdom
    J Immunol 177:6263-70. 2006
    ..In addition to this innate response, pDC also may play an immune regulatory role in reducing pulmonary inflammation and inhibiting the development of airway hyperresponsiveness...
  95. ncbi Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    Joseph P Bradley
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Pediatrics 115:e7-14. 2005
    ..Little is known about what determines the severity of RSV bronchiolitis, which may be helpful in the initial assessment of these children...
  96. ncbi Phosphorylation of human respiratory syncytial virus P protein at threonine 108 controls its interaction with the M2-1 protein in the viral RNA polymerase complex
    Ana Asenjo
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Crta Majadahonda Pozuelo km 2, Majadahonda, 28220 Madrid, Spain
    J Gen Virol 87:3637-42. 2006
    The human respiratory syncytial virus (HRSV) P protein is phosphorylated, with different turnover rates, at several serine (S) and threonine (T) residues...
  97. pmc Tissue-specific regulation of CD8+ T-lymphocyte immunodominance in respiratory syncytial virus infection
    Sujin Lee
    Department of Pediatrics, Vanderbilt University Medical Center, T 2220 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2905, USA
    J Virol 81:2349-58. 2007
    ..These studies will facilitate investigation of the regulation of immunodominance of RSV-specific CTL epitopes...
  98. pmc Characterization of recombinant respiratory syncytial viruses with the region responsible for type 2 T-cell responses and pulmonary eosinophilia deleted from the attachment (G) protein
    Matthew B Elliott
    Department of Immunology, Wyeth Vaccines Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    J Virol 78:8446-54. 2004
    ..These findings are important for the development of attenuated RSV vaccines...
  99. ncbi CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction
    Allison L Miller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 170:3348-56. 2003
    ..Thus, CXCR2 may be a relevant target in the pathogenesis of RSV bronchiolitis, since it contributes to mucus production and airway hyperreactivity in our model of RSV infection...
  100. ncbi Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms
    N W Lukacs
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    J Immunol 167:1060-5. 2001
    ..Overall, infection of the airways with RSV can induce an IL-13-dependent change in airway function and promotes an environment that contributes to the development of severe allergic asthmatic responses...
  101. ncbi Decreased replication of human respiratory syncytial virus treated with the proteasome inhibitor MG-132
    Christopher Lupfer
    Genetics Program, College of Agricultural Science, 3021 ALS Building, Oregon State University, Corvallis, OR 97331, United States
    Virus Res 149:36-41. 2010
    ..here that treatment of Vero cells with the proteasome inhibitor MG-132 results in the reduction of human respiratory syncytial virus (HRSV) titers by as much as 2.2log(10)...

Research Grants49

  1. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human respiratory syncytial virus (hRSV) is recognized as the most important viral agent of serious pediatric respiratory tract disease...
  2. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..genomes across the following panel of respiratory pathogens: influenza A virus, influenza B virus, human respiratory syncytial virus A/B, human adenovirus A/B/C/D/E/F, human coronavirus 229E/NL63/OC43, metapneumovirus, human ..
  3. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human respiratory syncytial virus (RSV) is a highly infectious member of the paramyxovirus family causing upper and lower respiratory tract infections...
  4. Neutrophil Subsets in Post-Viral Asthma
    Dorothy S Cheung; Fiscal Year: 2013
    ..In a mouse model utilizing Sendai virus (SeV), a paramyxovirus similar to the human Respiratory Syncytial Virus, a subset of the first responding neutrophils is found to be critical to the later development of ..
  5. Structural studies of respiratory syncytial virus
    Elizabeth R Wright; Fiscal Year: 2013
    ..The two families include numerous human pathogens such as human respiratory syncytial virus (hRSV), measles virus (MeV), human parainfluenza virus (hPIV), and the Influenza A, B, and C genera...
  6. Messenger RNA capping and methylation in pneumoviruses
    Jianrong Li; Fiscal Year: 2013
    ..Among the paramyxoviruses, human metapneumovirus (hMPV), human respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (hPIV3) account for more than 70% of acute viral ..
  7. Host factors involved in viral RNA recombination
    Peter Nagy; Fiscal Year: 2006
    ..dengue virus, infectious bronchitis virus, influenza A virus, hantavirus, hepatitis D virus, Human Respiratory Syncytial Virus, Corona-, Rota-, Flavi-, Calici-, Arteri-, Astro-, Entero-; and Alphaviruses...
  8. Humoral Immune Responses to Virus-like Particle Vaccine Candidates for RSV
    Trudy G Morrison; Fiscal Year: 2011
    Abstract Human respiratory syncytial virus (RSV) is recognized as the single most important cause of acute respiratory disease in infants and young children worldwide...
  9. THE HUMAN ANTIBODY RESPONSE TO METAPNEUMOVIRUS: PROPHYLAXIS AND VACCINE DESIGN
    Dennis R Burton; Fiscal Year: 2011
    ..It is closely related to human respiratory syncytial virus (HRSV), and produces an analogous clinical syndrome in infected individuals...
  10. HLA restriction and TCR affinity in HIV
    DANIEL GARRETT KAVANAGH; Fiscal Year: 2011
    ..we transpose a short genetic sequence (encoding and epitope) from a ubiquitous pathogen such as human respiratory syncytial virus (HRSV) into the HIV genome...
  11. MUCOSAL IMMUNE RESPONSE TO A RECOMBINANT RSV IMMUNOGEN
    SHARON ROBERTS; Fiscal Year: 1999
    b>Human respiratory syncytial virus (HRSV) is the most important viral cause of respiratory disease in very young children. Currently there are no vaccines available...
  12. Oncolytic activity of respiratory syncytial virus against prostate cancer
    Santanu Bose; Fiscal Year: 2009
    ..to manage prostate cancer based on selective killing of prostate tumor cells by the oncolytic human respiratory syncytial virus (RSV)...
  13. Heat shock protein modulation of paramyxoviral disease
    Michael Oglesbee; Fiscal Year: 2009
    ..g., human respiratory syncytial virus, an agent whose replication and host immune response can also be modeled in the cotton rat)...
  14. Mechanisms of RNA virus-host interaction
    Sailen Barik; Fiscal Year: 2009
    ..in the gene expression and signal transduction of negative-strand RNA viruses, using primarily the human respiratory syncytial virus (RSV) as a model...
  15. ANTI-ID AB VACCINE FOR HUMAN RESPIRATORY SYNCYTIAL VIRUS
    JOHN SLACK; Fiscal Year: 1992
    ..The implication of these results is that human sera contain antibodies analogous to the original anti-F. We propose to create hybridomas which secrete human antibodies against anti-F to be utilized as an intra-nasal vaccine...
  16. Generation of bPIV3-vectored PIV and RSV Vaccines
    AURELIA HALLER; Fiscal Year: 2002
    DESCRIPTION: (Adapted from Applicant's Abstract) Human parainfluenza virus (hPIV) and human respiratory syncytial virus (hRSV) are the main causes of acute respiratory diseases during infancy and early childhood worldwide, often ..
  17. BOVINE PARAINFLUENZA 3 VIRUS AS A NOVEL VACCINE VECTOR
    AURELIA HALLER; Fiscal Year: 1999
    ..the surface glycoproteins of human parainfluenza virus types l, 2 and 3 (hPIV1, 2, 3) and human respiratory syncytial virus (hRSV) (subgroups A and B) into the genetic genome of bPIV3. Both, hPIV and hRSV...
  18. MICROENCAPSULATED RESPIRATORY SYNCYTIAL VIRUS VACCINE
    Narayanasamy Elango; Fiscal Year: 1993
    The long term objective of this proposal is to develop a commercial subunit vaccine for human respiratory syncytial virus (RSV)...
  19. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  20. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ....
  22. Vulnerability to Smallpox Due to Declining CTL Immunity
    Innocent Mbawuike; Fiscal Year: 2003
    ..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
  23. IMMUNOGENETICS AND THE PATHOGENESIS OF RSV INFECTION
    John DeVincenzo; Fiscal Year: 2004
    ..With the help of this award, this goal can be achieved. ..
  24. Pathogenesis of RSV disease in the Elderly
    Edward Walsh; Fiscal Year: 2008
    ..abstract_text> ..
  25. PGE2 Regulation of Allergic Inflammation in the Lung
    RAY PEEBLES; Fiscal Year: 2007
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. [unreadable] [unreadable]..
  26. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..
  27. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  28. The Role of a Novel Coronavirus In Kawasaki Disease
    Jeffrey Kahn; Fiscal Year: 2007
    ..We have identified a novel human virus, designated the New Haven coronavirus that is associated with KD. The goals of this study is to investigate the role of this novel virus in KD. [unreadable] [unreadable]..
  29. Prostacyclin (PG12) Regulation of Respiratory Syncytial Virus (RS)induced Illness
    RAY PEEBLES; Fiscal Year: 2007
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  30. Congenital HHV6 Infection: Characteristics and Outcome
    Caroline Hall; Fiscal Year: 2007
    ..Correlation of these measurements with the viral and clinical characteristics in Aim I may allow early identification of risk factors that are predictive of future disabilities. ..
  31. CONTROL OF EPIDEMIC INFLUENZA
    PEDRO PIEDRA; Fiscal Year: 2007
    ..abstract_text> ..
  32. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  33. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  34. Antibody inhibition of respiratory syncytial virus G protein activity
    Ralph A Tripp; Fiscal Year: 2010
    ..abstract_text> ..
  35. PRIMARY HHV6 INFECTION--CLINICAL & VIRAL CHARACTERISTICS
    Caroline Hall; Fiscal Year: 2001
    ..A matched subgroup of 180 (90 with seizures from HHV-6 and 90 with seizures not from HHV-6) will be compared for neurologic development after 3 years by neurologic examinations and standardized neuropsychologic testing. ..
  36. Impact of Oseltamivir on Outcomes and Costs of Pediatric Influenza
    Susan Coffin; Fiscal Year: 2008
    ..The proposed project will enhance our understanding of influenza-specific antiviral therapy and its ability to alter the outcomes of children hospitalized with the influenza virus. [unreadable] [unreadable] [unreadable]..
  37. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2008
    ..abstract_text> ..
  38. Role of Virus and Genetic Susceptibility in Otitis Media
    Cuneyt Alper; Fiscal Year: 2006
    ..These results will be used in the design of future studies that prevent OM by moderating vURI pathogenesis. [unreadable] [unreadable]..
  39. Neonatal Immunization with Acellular Pertussis Vaccines
    Natasha Halasa; Fiscal Year: 2007
    ....
  40. BETAZAR POLYMORPHISMS AND AIRWAY SMOOTH MUSCLE
    Paul Moore; Fiscal Year: 2004
    ..Defining the beta2-AR genotypes that alter beta-agonist responses may thus have significant therapeutic consequences on the use of beta-agonists. ..
  41. Lymphocyte homing to the spleen
    MITCHELL GRAYSON; Fiscal Year: 2005
    ..Identification of mechanisms controlling entry of lymphocytes into the lymphoid compartment of the spleen will provide new targets for immunomodulatory drug therapy. ..
  42. Surfactant protein variants in pediatric lung injury
    Neal Thomas; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..Specific Aim 4: To determine if this multiplex assay is equivalent to these "singleplex" assays in a clinical trial. ..
  44. Immunobiology of Influenza Virus Infection: Approaches for an Emerging Zoonotic D
    Ralph Tripp; Fiscal Year: 2007
    ..abstract_text> ..
  45. HIV-1 entry inhibitors targeting Phe43 cavity in gp120
    Asim Debnath; Fiscal Year: 2003
    ..The long-term goal of this proposal is to optimize the lead compounds through chemical synthesis and structure activity analyses and select 3-4 best compounds for further preclinical studies as novel ianti-HIV-1 chemotherapeutic agents. ..
  46. Rational Design of CCR5 Antagonists as Anti-HIV-1 Drugs
    Asim Debnath; Fiscal Year: 2006
    ..The long term goal is to optimize the lead compounds through chemical syntheses and structure activity relationship (SAR) analyses and select the 3-4 best compounds for further preclinical studies. ..
  47. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2005
    ..4) explore the role of attachment in initiation of fusion. ..