rhinovirus

Summary

Summary: A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD.

Top Publications

  1. pmc Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    Peter A B Wark
    The Brooke Laboratories, University of Southampton, Southampton SO16 6YD, UK
    J Exp Med 201:937-47. 2005
  2. ncbi Role of deficient type III interferon-lambda production in asthma exacerbations
    Marco Contoli
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 12:1023-6. 2006
  3. pmc Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander
    Alicia M Fry
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e17780. 2011
  4. pmc Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life
    Daniel J Jackson
    University of Wisconsin, Madison, 53792, USA
    Am J Respir Crit Care Med 185:281-5. 2012
  5. pmc Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation
    Patrick Mallia
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Am J Respir Crit Care Med 183:734-42. 2011
  6. ncbi Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 9988, USA edu
    J Allergy Clin Immunol 116:571-7. 2005
  7. pmc Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
    Y A Bochkov
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Mucosal Immunol 3:69-80. 2010
  8. ncbi Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously
    Jong Hwan Wang
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Laryngoscope 119:1406-11. 2009
  9. pmc MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness
    Qiong Wang
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 7:e1002070. 2011
  10. ncbi Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells
    Tomoko Suzuki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 165:1113-8. 2002

Detail Information

Publications239 found, 100 shown here

  1. pmc Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    Peter A B Wark
    The Brooke Laboratories, University of Southampton, Southampton SO16 6YD, UK
    J Exp Med 201:937-47. 2005
    ..underlying mechanisms of this increased susceptibility, we examined virus replication and innate responses to rhinovirus (RV)-16 infection of primary bronchial epithelial cells from asthmatic and healthy control subjects...
  2. ncbi Role of deficient type III interferon-lambda production in asthma exacerbations
    Marco Contoli
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 12:1023-6. 2006
    Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections...
  3. pmc Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander
    Alicia M Fry
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e17780. 2011
    We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.
  4. pmc Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life
    Daniel J Jackson
    University of Wisconsin, Madison, 53792, USA
    Am J Respir Crit Care Med 185:281-5. 2012
    ..Aeroallergen sensitization and virus-induced wheezing are risk factors for asthma development during early childhood, but the temporal developmental sequence between them is incompletely understood...
  5. pmc Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation
    Patrick Mallia
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Am J Respir Crit Care Med 183:734-42. 2011
    ..We hypothesized that experimental rhinovirus infection in subjects with COPD would reproduce the features of naturally occurring COPD exacerbations and is a ..
  6. ncbi Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 9988, USA edu
    J Allergy Clin Immunol 116:571-7. 2005
    ..The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established...
  7. pmc Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
    Y A Bochkov
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Mucosal Immunol 3:69-80. 2010
    b>Rhinovirus (RV) infections trigger asthma exacerbations...
  8. ncbi Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously
    Jong Hwan Wang
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Laryngoscope 119:1406-11. 2009
    ..We investigate the effect of rhinovirus infection on the expression of cell adhesion molecules and bacterial adherence to primary human nasal epithelial ..
  9. pmc MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness
    Qiong Wang
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 7:e1002070. 2011
    b>Rhinovirus (RV), a single-stranded RNA picornavirus, is the most frequent cause of asthma exacerbations...
  10. ncbi Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells
    Tomoko Suzuki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 165:1113-8. 2002
    To examine the effects of erythromycin on rhinovirus (RV) infection in airway epithelium, primary cultures of human tracheal epithelial cells were infected with the RV major subgroup, RV14, and the minor subgroup, RV2...
  11. ncbi Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells
    Satoshi Ishizuka
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Infect Dis 188:1928-39. 2003
    To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S...
  12. ncbi Uncoating of human rhinoviruses
    Renate Fuchs
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Rev Med Virol 20:281-97. 2010
    ..Alternatively, the membrane may be ruptured allowing subviral particles and RNA to enter the cytosol. Whether a channel is formed or the membrane is disrupted most probably depends on the respective HRV receptor...
  13. ncbi The role of viruses in acute exacerbations of asthma
    David J Jackson
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 125:1178-87; quiz 1188-9. 2010
    ....
  14. pmc Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium
    Louise Slater
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS Pathog 6:e1001178. 2010
    ..We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epithelial cells...
  15. pmc Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses
    Xiaoyan Lu
    Gastroenteritis and Respiratory Virus Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 46:533-9. 2008
    ..The assay was successfully applied in an investigation of a coincidental outbreak of HRV respiratory illness among laboratory staff...
  16. pmc Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease
    Dina Schneider
    University of Michigan, Ann Arbor, MI 48109 5688, USA
    Am J Respir Crit Care Med 182:332-40. 2010
    Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection.
  17. ncbi Viruses in community-acquired pneumonia in children aged less than 3 years old: High rate of viral coinfection
    Gustavo Cilla
    Microbiology Department, Hospital Donostia, San Sebastian, Spain
    J Med Virol 80:1843-9. 2008
    ..syncytial virus (n = 67: 33 subgroup A, 33 subgroup B, 1 not typed), followed by human bocavirus (n = 48), rhinovirus (n = 46), human metapneumovirus (n = 39: 13 genotype A2, 8 B1, 5 B2, 1 A1, 12 not genotyped) and parainfluenza ..
  18. pmc Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection
    Clare A Stokes
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom
    J Virol 85:7912-21. 2011
    ..In this study we explored the roles of IL-1β and its signaling pathways in the responses of airway cells to rhinovirus-1B (RV-1B) and further determined how responses to RV-1B were modified in a model of bacterial coinfection...
  19. pmc Genetics, recombination and clinical features of human rhinovirus species C (HRV-C) infections; interactions of HRV-C with other respiratory viruses
    Anne Wisdom
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, United Kingdom
    PLoS ONE 4:e8518. 2009
    ..HRV-C's disease associations, its prevalence and evidence for interfering effects on other respiratory viruses mandates incorporation of rhinoviruses into future diagnostic virology screening...
  20. ncbi Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus
    Julie A Cakebread
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine and National Institute for Health Research Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 127:1148-54.e9. 2011
    ..studies suggest that primary bronchial epithelial cells (PBECs) from asthmatic subjects are more susceptible to rhinovirus infection because of deficient IFN-β production...
  21. ncbi Rhinoviruses delayed the circulation of the pandemic influenza A (H1N1) 2009 virus in France
    J S Casalegno
    Hospices Civils de Lyon, National Influenza Centre South of France, Laboratory of Virology, Bât A3, Bron Cedex, France
    Clin Microbiol Infect 16:326-9. 2010
    ..Systematic analysis for the detection of A(H1N1)2009 (H1N1) and human rhinovirus (HRV) was performed by RT-PCR from week 36 to week 48 on respiratory samples sent to the diagnostic laboratory ..
  22. pmc Analysis of genetic diversity and sites of recombination in human rhinovirus species C
    Chloe L McIntyre
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Virol 84:10297-310. 2010
    ..The extensive sequence data from multiple genome regions of HRV-C and analyses of recombination in the current study will assist future formulation of consensus criteria for HRV-C type assignment and identification...
  23. pmc Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses
    Qiong Wang
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 183:6989-97. 2009
    b>Rhinovirus (RV), a ssRNA virus of the picornavirus family, is a major cause of the common cold as well as asthma and chronic obstructive pulmonary disease exacerbations...
  24. pmc Liposomal nanocontainers as models for viral infection: monitoring viral genomic RNA transfer through lipid membranes
    Gerhard Bilek
    Max F Perutz Laboratories, Dept Med Biochemistry, Medical University of Vienna, Vienna, Austria
    J Virol 85:8368-75. 2011
    ..We here demonstrate the in vitro transfer of the single-stranded positive-sense RNA genome of human rhinovirus 2 into liposomes decorated with recombinant very-low-density lipoprotein receptor fragments...
  25. pmc Receptor priming of major group human rhinoviruses for uncoating and entry at mild low-pH environments
    Ghasem Nurani
    Karolinska Institute, Department of Biosciences at Novum, Center for Biotechnology, 141 57 Huddinge, Sweden
    J Virol 77:11985-91. 2003
    ..5 to 6.0). Agents preventing endosomal acidification reduced or blocked rhinovirus cell infection, while nocodazole had no effect on infection of any serotype tested...
  26. ncbi Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells
    N G Papadopoulos
    University Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 31:1060-6. 2001
    ..Induction of eosinophil chemoattractants could represent a central mechanism, as well as a prime target for intervention...
  27. ncbi Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection
    Jason C L Spurrell
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Alberta
    Am J Physiol Lung Cell Mol Physiol 289:L85-95. 2005
    Human rhinovirus (HRV) infections trigger exacerbations of asthma and chronic obstructive pulmonary disease (COPD) and are associated with lymphocytic infiltration of the airways...
  28. ncbi Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages
    B G G Oliver
    Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    Thorax 63:519-25. 2008
    b>Rhinovirus infection is responsible for considerable morbidity and mortality as the major cause of exacerbations of asthma, and is also known to induce exacerbations of cystic fibrosis and chronic obstructive pulmonary disease...
  29. ncbi Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells
    M R Khaitov
    Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute of Infection and Immunity and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London, UK
    Allergy 64:375-86. 2009
    ..Impaired production of interferon-beta in rhinovirus infected bronchial epithelial cells (BECs) and of the newly discovered interferon-lambdas in both BECs and ..
  30. pmc High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France
    Nathalie Schnepf
    Universite Paris Diderot, Sorbonne Paris Cité, Microbiology Department, Saint Louis Hospital, APHP, Paris, France
    PLoS ONE 6:e23514. 2011
    ..Clinical observations are of little help to recognise myxovirus infection and implement appropriate prevention measures. The limited use of molecular tools underestimates the role of other common pathogens...
  31. pmc Viruses and bacteria in the etiology of the common cold
    M J Mäkelä
    Department of Pediatrics, University of Turku, Finland
    J Clin Microbiol 36:539-42. 1998
    ..Bacterial infections were rare, supporting the concept that the common cold is almost exclusively a viral disease...
  32. ncbi Proposals for the classification of human rhinovirus species C into genotypically assigned types
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, UK
    J Gen Virol 91:2409-19. 2010
    ....
  33. ncbi Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays
    M T Coiras
    Laboratorio de Virus Respiratorios, Servicio de Virologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    J Med Virol 72:484-95. 2004
    ..regions of human parainfluenza virus haemagglutinin, human coronavirus spike protein, and human enterovirus and rhinovirus polyprotein genes...
  34. pmc Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    Nathan W Bartlett
    Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 14:199-204. 2008
    ..disease pathogenesis and to the development of effective therapies has been the lack of a small-animal model for rhinovirus infection...
  35. pmc Rhinovirus disrupts the barrier function of polarized airway epithelial cells
    Umadevi Sajjan
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0688, USA
    Am J Respir Crit Care Med 178:1271-81. 2008
    Secondary bacterial infection following rhinovirus (RV) infection has been recognized in chronic obstructive pulmonary disease.
  36. ncbi The major human rhinovirus receptor is ICAM-1
    J M Greve
    Molecular Therapeutics, Inc, Miles Research Center, West Haven, Connecticut 06516
    Cell 56:839-47. 1989
    The major human rhinovirus receptor has been identified with monoclonal antibodies that inhibit rhinovirus infection...
  37. ncbi Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD
    Tom M A Wilkinson
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London School of Medicine, St Bartholomew s Hospital, London, UK
    Chest 129:317-24. 2006
    ....
  38. ncbi Similar frequency of rhinovirus-infectible cells in upper and lower airway epithelium
    Anne G Mosser
    Department of Medicine, Division of Allergy and Immunology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Infect Dis 185:734-43. 2002
    b>Rhinovirus (RV) infections can alter lower airway physiology and inflammation, yet the characteristics of RV replication in lower airway cells are incompletely understood...
  39. pmc Elastase- and LPS-exposed mice display altered responses to rhinovirus infection
    Umadevi Sajjan
    Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W Medical Center Dr, Rm 3570, MSRBII, Box 5688, Ann Arbor, MI 48109 5688, USA
    Am J Physiol Lung Cell Mol Physiol 297:L931-44. 2009
    ..of elastase and LPS, a constituent of cigarette smoke and a risk factor for development of COPD, with rhinovirus serotype 1B, and examined animals for viral persistence, airway resistance, lung volume, and cytokine responses...
  40. ncbi Gene expression profiles during in vivo human rhinovirus infection: insights into the host response
    David Proud
    Department of Physiology and Biophysics, Health Sciences 1626, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
    Am J Respir Crit Care Med 178:962-8. 2008
    Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases.
  41. pmc New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses
    Caroline Tapparel
    University of Geneva Hospitals, Switzerland
    Emerg Infect Dis 15:719-26. 2009
    ..and identify forces shaping picornavirus evolution, we screened persons with respiratory illnesses by using rhinovirus-specific or generic real-time PCR assays...
  42. pmc Evidence of recombination and genetic diversity in human rhinoviruses in children with acute respiratory infection
    Ting Huang
    Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai Institute of Biological Sciences, Unit of Emerging Viruses, Shanghai, PR China
    PLoS ONE 4:e6355. 2009
    ....
  43. pmc High rate of viral identification and coinfections in infants with acute bronchiolitis
    Milena Siciliano Nascimento
    Departamento de Saúde Materno Infantil, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Clinics (Sao Paulo) 65:1133-7. 2010
    ..To determine the viruses and risk factors associated with hospital and intensive care unit (ICU) admissions in infants with acute bronchiolitis...
  44. pmc Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope
    Gail Ferstandig Arnold
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854 5638, USA
    J Virol 83:5087-100. 2009
    ....
  45. pmc Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection
    Tuende Konecsni
    Max F Perutz Laboratories, University Department at the Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    J Virol 83:10922-30. 2009
    ..This is a nice example of a virus exploiting high-avidity multimodule receptor binding with an intrinsic release mechanism...
  46. ncbi Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
    J Nutr Biochem 20:577-85. 2009
    b>Rhinovirus infection results in increased release of inflammatory mediators from airway epithelial cells in asthma. As an antioxidant, lycopene offers protection from adverse effects of inflammation...
  47. pmc Structural analysis of human rhinovirus complexed with ICAM-1 reveals the dynamics of receptor-mediated virus uncoating
    Li Xing
    Department of Biosciences, Karolinska Institute, 141 57 Huddinge, Sweden
    J Virol 77:6101-7. 2003
    ..These observations suggest that receptor-mediated uncoating could be a consequence of restrained capsid motion, where the bound receptors maintain the viral capsid in an expanded open state for subsequent genome release...
  48. pmc Insights into minor group rhinovirus uncoating: the X-ray structure of the HRV2 empty capsid
    Damiá Garriga
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Barcelona, Spain
    PLoS Pathog 8:e1002473. 2012
    ..The structural comparison between native and empty HRV2 particles unveils a number of pH-sensitive amino acid residues, conserved in rhinoviruses, which participate in the structural rearrangements involved in the uncoating process...
  49. pmc Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes
    Kelly Watters
    Institute for Molecular Virology, Robert M Bock Laboratories, University of Wisconsin Madison, 1525 Linden Dr, Madison, WI 53706, USA
    J Virol 85:10874-83. 2011
    ....
  50. pmc Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53716, USA
    J Allergy Clin Immunol 128:532-8.e1-10. 2011
    Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood.
  51. ncbi Modulation of the epithelial inflammatory response to rhinovirus in an atopic environment
    M Xatzipsalti
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Exp Allergy 38:466-72. 2008
    Immune responses to rhinovirus (RV) as well as direct effects of RV on respiratory epithelium may contribute to the induction of asthma exacerbations.
  52. ncbi Virus interference. Did rhinoviruses activity hamper the progress of the 2009 influenza A (H1N1) pandemic in Norway?
    Gabriel Anestad
    Department of Virology, Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
    Med Hypotheses 77:1132-4. 2011
    ..If so, cytokines, in particular interferon, are the most probable executor of this effect...
  53. ncbi Wortmannin delays transfer of human rhinovirus serotype 2 to late endocytic compartments
    Marianne Brabec
    Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Biochem Biophys Res Commun 348:741-9. 2006
    Human rhinovirus 2 (HRV2) is internalized by members of the low-density lipoprotein receptor family into early endosomes (pH 6.2-6.0) where it dissociates from its receptors...
  54. ncbi Effect of clarithromycin on rhinovirus-16 infection in A549 cells
    Y J Jang
    Dept of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2dong, Songpa Gu, Seoul, 138 736, South Korea
    Eur Respir J 27:12-9. 2006
    ..of interleukin (IL)-6 and IL-8, which may have beneficial effects on the pathophysiological changes related to rhinovirus (RV) infection. The effect of CM on RV infection in A549 cells was therefore investigated...
  55. pmc A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Respir Crit Care Med 185:508-16. 2012
    ..Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear...
  56. pmc Recombinant VP4 of human rhinovirus induces permeability in model membranes
    Matthew P Davis
    Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 82:4169-74. 2008
    ..Here we show that recombinant VP4 of human rhinovirus 16 has the ability to associate with and induce membrane permeability in otherwise intact liposomes...
  57. pmc Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport
    Reena Ghildyal
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Virol 83:7349-52. 2009
    The degradation of nuclear pore components and disruption of nucleocytoplasmic trafficking during rhinovirus infection have been attributed to viral 2A protease...
  58. ncbi Effects of tumor necrosis factor-alpha, epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by, and human rhinovirus replication in, bronchial epithelial cells
    M C Subauste
    Johns Hopkins Asthma and Allergy Center, Unit Office 2, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6801, USA
    Int Immunopharmacol 1:1229-34. 2001
    ..Moreover, TNF-alpha increased viral replication in the presence of EGF but not TGF-alpha. In conclusion, this study demonstrates that both EGF and TGF-alpha play an active role in the pathogenesis of airway inflammation...
  59. ncbi Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro
    Katsuhito Iikura
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 155:27-33. 2011
    Asthmatic patients have a higher susceptibility to rhinovirus (RV) infection, and impaired IFN-β and IFN-λ production has been demonstrated in bronchial epithelial cells from asthmatic adults upon exposure to RV...
  60. ncbi Rhinovirus 16-induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients
    Annemarie Sykes
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 129:1506-1514.e6. 2012
    Asthmatic patients have defective rhinovirus-induced IFN-β and IFN-λ production from bronchial epithelial cells and IFN-λ from bronchoalveolar lavage (BAL) cells...
  61. ncbi Type 2 rhinovirus infection of cultured human tracheal epithelial cells: role of LDL receptor
    T Suzuki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980-8574, Japan
    Am J Physiol Lung Cell Mol Physiol 280:L409-20. 2001
    To examine the role of the low-density lipoprotein (LDL) receptor on minor group human rhinovirus (RV) infection, primary cultures of human tracheal epithelial cells were infected with a minor group (RV2) or a major group (RV14) RV...
  62. pmc Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD
    Jennifer K Quint
    Academic Unit of Respiratory Medicine, University College London, Rowland Hill St, London NW3 2PF, England
    Chest 137:812-22. 2010
    Human rhinovirus (HRV) is the most frequent virus associated with COPD exacerbations. Viral infections increase exacerbation severity and likelihood of hospitalization...
  63. pmc Rhinovirus genome variation during chronic upper and lower respiratory tract infections
    Caroline Tapparel
    Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University of Geneva Hospitals, Geneva, Switzerland
    PLoS ONE 6:e21163. 2011
    ..of lung transplant recipients and hospital patients for respiratory virus infections allowed to identify human rhinovirus (HRV) in the upper and lower respiratory tracts, including immunocompromised hosts chronically infected with the ..
  64. pmc Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16
    Jennifer P DeMore
    Department of Medicine, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 124:245-52, 252.e1-3. 2009
    b>Rhinovirus infections are frequent causes of asthma exacerbations.
  65. pmc Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease
    Manisha Singh
    Department of Medicine, Division of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Tex, USA
    J Allergy Clin Immunol 125:1369-1378.e2. 2010
    ..Acute exacerbation of COPD (AE-COPD) is commonly associated with upper and lower respiratory tract viral infections and can result in respiratory failure in those with advanced lung disease...
  66. ncbi Rhinovirus infections in the upper airway
    Birgit Winther
    University of Virginia Health System, Department of Otolaryngology, Head and Neck Surgery, P O Box 800713, Charlottesville, VA 22908, USA
    Proc Am Thorac Soc 8:79-89. 2011
    ..The clinical complications related to all rhinovirus infections include acute otitis media, acute sinusitis, and acute bronchitis...
  67. ncbi Asian sand dust enhances rhinovirus-induced cytokine secretion and viral replication in human nasal epithelial cells
    Nam Kyung Yeo
    Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea
    Inhal Toxicol 22:1038-45. 2010
    ..Among the most common respiratory illnesses is the common cold caused by rhinovirus (RV) infection. To date, however, the impact of ASD on RV infection has not been studied.
  68. ncbi Clarithromycin inhibits rhinovirus-induced bacterial adhesions to nasal epithelial cells
    Jong Hwan Wang
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Laryngoscope 120:193-9. 2010
    We investigated the inhibitory effects of clarithromycin (CM) on the rhinovirus (RV)-induced expression of fibronectin (Fn) and carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which act as major receptors for ..
  69. ncbi Rhinovirus infection induces extracellular matrix protein deposition in asthmatic and nonasthmatic airway smooth muscle cells
    Curtis Kuo
    Discipline of Pharmacology, University of Sydney, Camperdown, Australia
    Am J Physiol Lung Cell Mol Physiol 300:L951-7. 2011
    ..b>Rhinovirus (RV) infections are associated with increased risk of asthma development in young children and are the most ..
  70. pmc Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response
    Kathy Triantafilou
    University of Sussex, Infection and Immunity Group, School of Life Sciences, Falmer, Brighton, UK
    Virulence 2:22-9. 2011
    ..In this study we investigated the specific recognition of Human rhinovirus 6 (HRV6) the common cold pathogen by the innate immune response in lung epithelial cells...
  71. ncbi Role of rhinovirus C respiratory infections in sick and healthy children in Spain
    Cristina Calvo
    Department of Pediatrics, Hospital Severo Ochoa, Leganes, Madrid, Spain
    Pediatr Infect Dis J 29:717-20. 2010
    Recently a new genogroup of human rhinovirus (HRV) has been described and named HRV-C. The relative importance of HRV-C in viral respiratory tract illnesses is unknown.
  72. ncbi Human rhinoviruses: the cold wars resume
    Ian M Mackay
    Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Queensland, Australia
    J Clin Virol 42:297-320. 2008
    ..Early findings from infection studies and use of inefficient detection methods have shaped the way we think of 'common cold' viruses today...
  73. pmc Rhinovirus genome evolution during experimental human infection
    Samuel Cordey
    Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University of Geneva Hospitals, Geneva, Switzerland
    PLoS ONE 5:e10588. 2010
    ..In vivo, HRV generate new variants rapidly during the course of an acute infection due to mutations that accumulate in hot spot regions located at the capsid level, as well as in 2C and 3C genes...
  74. ncbi Clinical severity and molecular typing of human rhinovirus C strains during a fall outbreak affecting hospitalized patients
    A Piralla
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Clin Virol 45:311-7. 2009
    The circulation rate and the clinical severity of infections caused by members of the new human rhinovirus C (HRV-C) species remain to be defined.
  75. ncbi A novel group of rhinoviruses is associated with asthma hospitalizations
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 9500, USA
    J Allergy Clin Immunol 123:98-104.e1. 2009
    ..Although recent studies have identified new group C human rhinoviruses (HRVCs), their spectrum of pediatric disease is unknown...
  76. pmc Microarray-based detection and genotyping of viral pathogens
    David Wang
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15687-92. 2002
    ..This method is versatile and greatly expands the spectrum of detectable viruses in a single assay while simultaneously providing the capability to discriminate among viral subtypes...
  77. pmc Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages
    Deepti R Nagarkar
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:2525-35. 2010
    Human rhinovirus is responsible for the majority of virus-induced asthma exacerbations...
  78. pmc New molecular detection tools adapted to emerging rhinoviruses and enteroviruses
    Caroline Tapparel
    Laboratory of Virology, Division of Infectious Diseases, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    J Clin Microbiol 47:1742-9. 2009
    ..This investigation provides a comprehensive toolbox for accurate molecular identification of the different HEV and HRV circulating in humans...
  79. pmc Human rhinovirus C associated with wheezing in hospitalised children in the Middle East
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN, USA
    J Clin Virol 46:85-9. 2009
    ..Few studies have investigated the disease burden and genetic diversity of human rhinoviruses (HRVs) in developing countries...
  80. pmc Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection
    N L Korpi-Steiner
    Department of Biomolecular Chemistry, Division of Allergy and Immunology, University of Wisconsin Madison, Madison, WI 53706 0450, USA
    Clin Exp Allergy 40:1203-13. 2010
    Human rhinovirus (HRV) infections are a major cause of exacerbations in chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease, but HRV-induced immune responses of the lower airway are poorly understood...
  81. pmc Cleavage of IPS-1 in cells infected with human rhinovirus
    Jennifer Drahos
    Department of Microbiology and Immunology, College of Physicians and Surgeons of Columbia University, 701 West 168th St, New York, NY 10032, USA
    J Virol 83:11581-7. 2009
    ..The innate immune response to rhinovirus infection, which may play an important role in virus-induced asthma induction, has not been comprehensively ..
  82. ncbi Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    Peter A B Wark
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, UK
    Respirology 14:180-6. 2009
    Infection with rhinovirus (RV) is the most common trigger for acute asthma and COPD. The aim of this study was to characterize the variability in the response of primary bronchial epithelial cells to infection with several strains of RV.
  83. ncbi Phylogenetic relationships and molecular adaptation dynamics of human rhinoviruses
    Nicole Lewis-Rogers
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, USA
    Mol Biol Evol 26:969-81. 2009
    ..Our results demonstrate that HRV-A major, HRV-A minor, and HRV-B serotypes have not been similarly influenced by purifying selection...
  84. pmc Multiple receptors involved in human rhinovirus attachment to live cells
    Christian Rankl
    Institute for Biophysics, Christian Doppler Laboratory for Nanoscopic Methods in Biophysics, University of Linz, Altenbergerstrasse 69, A 4040 Linz, Austria
    Proc Natl Acad Sci U S A 105:17778-83. 2008
    ..The number of receptors involved in virus binding was determined, and estimates for on-rate, off-rate, and equilibrium binding constant of the interaction between HRV2 and plasma membrane-anchored receptors were obtained...
  85. ncbi Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms
    Kristiina Malmström
    Department of Allergy, Helsinki University Central Hospital, Finland
    J Allergy Clin Immunol 118:591-6. 2006
    ..Human rhinoviruses (HRVs) are a common cause of upper respiratory tract infections. There is growing evidence that HRVs are also important in lower respiratory tract infections and often induce asthma exacerbations...
  86. ncbi Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells
    Michael R Edwards
    Department of Respiratory Medicine, National Heart Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London W2 1PG, UK
    Mol Immunol 44:1587-97. 2007
    b>Rhinovirus infections cause the majority of acute exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease, with increased pro-inflammatory cytokine production by infected bronchial epithelial cells ..
  87. ncbi Rhinovirus-associated hospitalizations in young children
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
    J Infect Dis 195:773-81. 2007
    ..Rhinoviruses frequently cause the common cold but have not been considered important causes of acute respiratory hospitalizations in children...
  88. pmc Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Respir Res 10:85. 2009
    b>Rhinovirus (RV) associated early wheezing has been recognized as an independent risk factor for asthma. The risk is more important than that associated with respiratory syncytial virus (RSV) disease...
  89. ncbi Rhinovirus infection in hospitalized children in Hong Kong: a prospective study
    Daniel K L Cheuk
    Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    Pediatr Infect Dis J 26:995-1000. 2007
    To analyze the clinical features and estimate the hospitalization disease burden of rhinovirus infection in children in Hong Kong.
  90. ncbi Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants
    F Midulla
    Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00165 Rome, Italy
    Arch Dis Child 95:35-41. 2010
    To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection.
  91. pmc CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection
    Deepti R Nagarkar
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 5688, USA
    J Immunol 183:6698-707. 2009
    Human rhinovirus (RV) infection is responsible for the majority of virus-induced asthma exacerbations...
  92. ncbi Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003
    K E Arden
    Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital, Queensland, Australia
    J Clin Virol 47:219-23. 2010
    ....
  93. pmc Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness
    Peter F Wright
    Vanderbilt University, D 7219 MCN, Nashville, TN 37232, USA
    J Clin Microbiol 45:2126-9. 2007
    ..The limited association of HRV RNA with illness suggests caution in assigning causality of HRV PCR positivity to clinical symptoms of respiratory illness...
  94. ncbi Reduced nasal IL-10 and enhanced TNFalpha responses during rhinovirus and RSV-induced upper respiratory tract infection in atopic and non-atopic infants
    I J van Benten
    Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Med Virol 75:348-57. 2005
    b>Rhinovirus and respiratory syncytial virus (RSV) are the most prevalent inducers of upper respiratory tract infections (URTI) in infants and may stimulate immune maturation...
  95. ncbi Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection
    K Grunberg
    Department of Pulmonology, Department of Medical Decision Making, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Am J Respir Crit Care Med 164:1816-22. 2001
    Asthma exacerbations are frequently linked to rhinovirus infections. However, the associated inflammatory pathways are poorly understood, and treatment of exacerbations is often unsatisfactory...
  96. pmc Human rhinovirus type 2-antibody complexes enter and infect cells via Fc-gamma receptor IIB1
    Günther Baravalle
    Department of Pathophysiology, The Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    J Virol 78:2729-37. 2004
    ..Binding of the minor-group human rhinovirus type 2 (HRV2) to its natural receptors, members of the low-density lipoprotein receptor family, is dependent on ..
  97. pmc Early detection of acute rhinovirus infections by a rapid reverse transcription-PCR assay
    C Steininger
    Institute of Virology, University of Vienna, A-1095 Vienna, Austria
    J Clin Microbiol 39:129-33. 2001
    The development of a rhinovirus (RV)-RNA-specific reverse transcription (RT)-PCR assay is complicated by the close homology between the RV and enterovirus (EV) genomes in the highly conserved 5'-noncoding region, which is chosen for ..
  98. ncbi Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital
    Katherine E Arden
    Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital and Clinical Medical Virology Centre, University of Queensland, Brisbane, Queensland, Australia
    J Med Virol 82:1458-61. 2010
    ..Larger, PCR-based studies are required to elucidate further the true impact of HRV species in childhood asthma exacerbations of both hospitalized and non-hospitalized cohorts...
  99. ncbi Inhibition of clathrin-dependent endocytosis has multiple effects on human rhinovirus serotype 2 cell entry
    N Bayer
    Departments of Pathophysiology and Medical Chemistry, University of Vienna, A-1090 Vienna, Austria
    J Biol Chem 276:3952-62. 2001
    Minor group human rhinoviruses (exemplified by human rhinovirus serotype 2 (HRV2)) use members of the low density lipoprotein receptor family for cell entry; all these receptors possess clathrin-coated pit localization signals...
  100. ncbi Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects
    N G Papadopoulos
    University Medicine, Southampton General Hospital, Southampton, London, UK
    Clin Exp Allergy 32:537-42. 2002
    b>Rhinovirus (RV) infection is the commonest trigger of acute asthma exacerbations; however, the immune response to these viruses and any potential implications in the mechanisms leading to asthma exacerbations are not well understood.
  101. ncbi The role of rhinovirus in asthma exacerbations
    Samuel L Friedlander
    Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 116:267-73. 2005
    ..b>Rhinovirus is a member of the family Picornaviridae, and acute rhinovirus infections occur predominantly in the upper ..

Research Grants62

  1. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..such as respiratory syncytial virus, human parainfluenza virus, human metapneumovirus, influenza virus, and rhinovirus. In Aim 3, we will establish in vitro bacterial biofilms with nontypeable Haemophilus influenzae (NTHi) or with ..
  2. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    DESCRIPTION (as provided by applicant): Recent studies utilizing PCR-based diagnostics have demonstrated that rhinovirus (HRV) is an important cause of lower respiratory illness including bronchiolitis, influenza-like illness, and ..
  3. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013
    ..Our experiments are designed to determine how specific host proteins detect and destroy human enterovirus and rhinovirus mRNAs and how these viruses evade and counteract such host enzymes to maintain the integrity of their RNA ..
  4. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    ..Streptococcus pneumonia, Haemophilus influenza, Staphylococcus aureus, Pseudomonas aeruginosa) and viral (rhinovirus, influenza virus) infections are responsible for a tremendous burden of hospitalizations and deaths...
  5. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..syncytial virus A/B, human adenovirus A/B/C/D/E/F, human coronavirus 229E/NL63/OC43, metapneumovirus, human rhinovirus A/B/C, human bocavirus 1/2/3/4, human parainfluenza virus 1/2/3/4, Haemophilus influenzae, Streptococcus ..
  6. Molecular Biology of Eukaryotic Viruses
    Bert L Semler; Fiscal Year: 2012
    ..being studied include murine leukemia virus, a sheep retrovirus (JSRV), HIV, yeast Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis virus, SARS coronavirus, arenaviruses, herpes simplex virus, Epstein-Barr virus,..
  7. Functions of 5'NCRs of picornavirus and cellular mRNAs
    Bert L Semler; Fiscal Year: 2013
    ..Poliovirus, coxsackievirus, and human rhinovirus are members of the Picornaviridae that share a common RNA secondary structure in their 5'NCRs required for ..
  8. Deep Sequencing for the Detection of Viral Sequences in Primary Progressive Multi
    John D Kriesel; Fiscal Year: 2012
    ..using molecular techniques including hepatitis C (1991), corona virus NL63 (2004), bocavirus (2005), and rhinovirus C group (2007)...
  9. Development of the Cotton Rat Model of Rhinovirus Infection and Disease
    JORGE C BLANCO; Fiscal Year: 2013
    ..The morbidity and mortality attributable to rhinovirus infection is considerable and results in billions of dollars of health care cost every year...
  10. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..These studies will focus on the mechanisms by which Rhinovirus acts to cause exacerbation of allergic asthma...
  11. Stress, Cellular Aging and Susceptibility to Infectious Disease
    Sheldon A Cohen; Fiscal Year: 2010
    ..After completing all baseline measures, subjects are exposed to a safety tested rhinovirus and monitored in quarantine for the development of infection and illness...
  12. Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..related to the pathogenesis of asthma, other chronic pulmonary disorders, and acute viral infection by rhinovirus. The application is based on novel data demonstrating the critical roles of the proposed transcriptional network ..
  13. Co-infections of rhinovirus and bacteria in chronic lung disorders
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..Our pilot studies indicate that pre-infection of well-differentiated airway epithelial cell cultures with rhinovirus (RV), the virus responsible for most respiratory tract infections, increases binding of both non- typeable ..
  14. Sex-specific genetic architecture of asthma risk in children
    Dagan A Loisel; Fiscal Year: 2010
    ..patterns, measured by DMA microarrays, will be used to identify genes that are differentially expressed in rhinovirus stimulated mononuclear cells from children with high levels of interferon-gamma response (i.e...
  15. An Evaluation of Treatment with Omalizumab to Improve the Asthmatic Response to a
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..years of age) and among young adults are triggered by a viral infection, predominantly infections caused by rhinovirus (RV)...
  16. Pathogenesis of Virus-Induced Acute Otitis Media
    Tasnee Chonmaitree; Fiscal Year: 2013
    ..Aim 2: Characterize rhinovirus and RSV that are detected repeatedly in sequential samples, to differentiate new infection from prolonged ..
  17. Structure and function of icosahedral viruses
    Michael G Rossmann; Fiscal Year: 2013
    ..The first success came in 1985 with the work on human rhinovirus serotype 14...
  18. POLIOVIRUS GENE FUNCTION AND REGULATION
    Bert L Semler; Fiscal Year: 2013
    ..Poliovirus, coxsackievirus, and human rhinovirus are members of the Picornaviridae that share a common RNA replication strategy during their intracellular ..
  19. The PIP2-virus interface and PI 4-kinase: novel biology and validation targets
    Jeffrey S Glenn; Fiscal Year: 2013
    ..Similar BAAPP domains are found in pathogens as diverse as rhinovirus and P. falciparum...
  20. Role of Type I Interferon in Allergic Asthma
    SARAH RUTH GONZALES-VAN HORN; Fiscal Year: 2013
    ..with lower respiratory tract infections in children, including influenza, respiratory syncytial virus and rhinovirus infections...
  21. Towards the Disruption of Viral RNA Replication
    Esther Bullitt; Fiscal Year: 2013
    ..provided by applicant): Diseases caused by positive-sense single-stranded RNA viruses, including poliovirus, rhinovirus, hepatitis C virus, and SARS, are critical health issues worldwide...
  22. Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent Wheezing
    Carlos A Camargo; Fiscal Year: 2013
    ..3- to 1.8-fold difference in the development of recurrent wheezing for comparisons of children with rhinovirus bronchiolitis (vs. RSV or other pathogens), admitted to the intensive care unit (vs...
  23. Developing ICAM-1 for rhinovirus therapeutics
    Moonsoo M Jin; Fiscal Year: 2010
    ..Due to the large number of HRV serotypes, little immunological protection is offered by prior rhinovirus exposure, rendering vaccination approaches ineffective...
  24. Beneficial effects of quercetin in COPD - a preliminary clinical trial
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2013
    ..of chronic obstructive lung disease (COPD) Our pilot studies also suggest that quercetin inhibits replication of rhinovirus, a major cause of COPD exacerbations...
  25. Duox2 Modulation of Viral Infection in Airway Epithelium
    Richart W Harper; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Rhinovirus (RV) is an important pathogen present in the respiratory tract epithelium of a significant proportion of asthma patients during severe pulmonary exacerbations...
  26. Midcareer Investigator Patient-oriented Research Award in Bronchiolitis &Asthma
    Tina V Hartert; Fiscal Year: 2013
    ..Lower respiratory tract infections (LRTI), caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants...
  27. Effect of Rhinovirus on airway epithelial reciprocal pathways influence NK cells.
    Jonathan Koff; Fiscal Year: 2013
    ..This interest arose from knowledge that Rhinovirus (RV) infections are responsible for exacerbations of chronic airway diseases...
  28. Mechanisms of Rhinovirus-Induced Exacerbations of Asthma
    James E Gern; Fiscal Year: 2010
    ..Collectively, these will studies address clinically relevant gaps in our current understanding of virus-induced airway dysfunction and facilitate the development of new and more efficacious therapeutic strategies. ..
  29. Rates of rhinovirus species in adults and children with acute respiratory illness
    EVA KATHRYN MILLER; Fiscal Year: 2013
    ..This may ultimately allow for a more targeted vaccine to be developed against HRV and may shed light on certain groups, such as those with asthma or COPD, at risk for more severe HRV-associated disease. ..
  30. LTQ Velos Pro mass spectrometer with ETD and other options
    Paul D Gershon; Fiscal Year: 2013
    ..Gershon);global cellular responses to polio and rhinovirus (Dr. Semler) and Chlamydia infection (Dr...
  31. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..b>Rhinovirus infections have begun to emerge as principal contributors to many phases of asthma including inception and ..
  32. Rhinovirus and Airway Epithelial Cell Responses
    Marc B Hershenson; Fiscal Year: 2013
    Project Summary/Abstract Viral infections, most commonly by human rhinovirus (HRV), are the most frequent cause of asthma attacks...
  33. Estimates of Influenza Vaccine Effectiveness
    Peter G Szilagyi; Fiscal Year: 2010
    ..cases will be compared with controls who are positive for respiratory syncytial virus, human metapneumovirus, or rhinovirus. Two broad populations will be assessed: children from 6 months of age to 13 years, and adults 50 years of age ..
  34. Lung HRV: G-Protein Coupled Signaling Interactions in Asthma
    Stephen B Liggett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human rhinovirus (HRV) infection causes at least 50% of asthma exacerbations...
  35. Regulation of Pro-Asthmatic and Glucocorticoid Signaling by Airway Smooth Muscle
    MICHAEL MATEIU GRUNSTEIN; Fiscal Year: 2012
    ..regulation of cytokine release and action in ASM sensitized by atopic (IgE) and by non-atopic stimuli including rhinovirus, dust mite allergen, or lipopolysaccharide;2) Gi protein-mediated MAPK activation, resulting in altered PDE4 ..
  36. Rhinovirus Infections and Asthma in Children and Adolescents
    Robert F Lemanske; Fiscal Year: 2013
    ..Our central theme is that human rhinovirus (HRV) infections during childhood and adolescence contribute mechanistically to the development of specific ..
  37. Airway Inflammation and Airway Remodeling
    David H Broide; Fiscal Year: 2013
    ..Croft, Zuraw) that will investigate mechanisms of airway remodeling in asthmatics exposed to allergen and rhinovirus common triggers of asthma...
  38. Leukocyte Signaling in Virus-Induced Asthma Exacerbation
    David Hall; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The long-range goal of this research proposal is to elucidate how rhinovirus (RV) activation of macrophages contributes to the exacerbations of asthma...
  39. Masking the GH-loop: model for human Rhinovirus vaccine
    Peter Nara; Fiscal Year: 2001
    ..Foot and Mouth Disease Virus (FMDV) is to be used as a proof of concept model for studying human rhinovirus infection as there is no useful animal model for human Rhinovirus infection...
  40. THE CLOUD ADULT
    Robert Sherertz; Fiscal Year: 2003
    ..The central hypothesis is that a viral URI (rhinovirus infection) will cause nasal carriers of Staphylococcus aureus to have airborne dispersal of S...
  41. ANTIVIRAL EFFECTS OF EOSINOPHILS IN THE LUNGS
    David Jacoby; Fiscal Year: 2007
    ..In specific aim #1, we will test the ability of human eosinophils to kill virus (parainfluenza, influenza, rhinovirus, and respiratory syncytial virus) in vitro...
  42. STRUCTURE, SYNTHESIS AND ASSEMBLY OF PICORNAVIRUSES
    ROLAND RUECKERT; Fiscal Year: 1991
    ..organized as 12 pentamers, and the atomic structure of the protein subunit is now known for three of them: human rhinovirus 14 (HRV14), type 1 poliovirus (PV1) and mengovirus...
  43. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..hypothesis is that glutaminase can be downregulated by interferon-gamma (IFN-gamma) from T cells responding to rhinovirus (RV), and that the pH fall acts on already inflamed lung to exacerbate attacks of asthma...
  44. STRUCTURE OF POLIOVIRUS/ANTIVIRAL DRUG COMPLEXES
    JAMES HOGLE; Fiscal Year: 1991
    ..These drugs are of considerable medical and economic significance for prophylaxis of rhinovirus induced common cold (which account for 80% of the colds in the United States) and for early intervention in ..
  45. INHIBITION OF NUCLEO-CYTOPLASMIC TRANSPORT BY RHINOVIRUS
    KURT GUSTIN; Fiscal Year: 2005
    ..form of viral respiratory illness is the common cold, which is itself most often associated with infection by rhinovirus. Viral respiratory infections are the most common acute illness in the US and children are the most frequent ..
  46. Exhaled Biomarkers During Treatment of Rhinovirus
    John Hunt; Fiscal Year: 2004
    b>Rhinovirus is a well-recognized, epidemiologically important cause of exacerbations of lower respiratory diseases including asthma, COPD, and cystic fibrosis...
  47. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 2000
    ..These studies will use PCR for rhinovirus and simple markers of inflammation (e.g...
  48. Immune Dampening the OMPs of non-typeable H. influenzae
    Peter Nara; Fiscal Year: 2004
    ..influenzae (NTHI), Streptococcus pneumoniae and Moraxella catarrhalis), their viral co-pathogens (Influenza, Rhinovirus, Adenovirus etc) and our inadequate understanding of the pediatric immune response during OM has presented ..
  49. TRANSLATION-INHIBITION OF HEPATITIS C AND POLIO VIRUSES
    Asim Dasgupta; Fiscal Year: 2003
    ..A) and chronic hepatitis (hepatitis C), common cold (rhinovirus), and myocarditis and encephalitis (coxsackie) among others...
  50. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..Of the respiratory viruses associated with exacerbations of asthma, rhinovirus (RV) is the most frequent and important cause of these episodes...
  51. CONSTRAINED HIV1 GP41 ELDKWA PEPTIDES FOR AIDS VACCINES
    John Taylor; Fiscal Year: 2000
    ..New structural insights obtained from separate, parallel studies of combinatorial libraries of human rhinovirus/ELDKWA chimeras will also be incorporated...
  52. INTERLEUKIN 11 IN VIRAL ASTHMA
    Jack Elias; Fiscal Year: 2000
    ..IL-11 in response to cytokines, histamine, eosinophil major basic protein, respiratory syncytial virus (RSV), rhinovirus and parainfluenza virus Type 3...
  53. HIV COMPONENTS FOR THE DESIGN--ANTIVIRAL DESIGN/ANALYSIS
    MICHAEL ROSSMANN; Fiscal Year: 1992
    ..To obtain experience we shall continue to study such drugs bounds to various rhinovirus strains, design drugs for other picornaviruses (of yet unknown structures) (program D1) and attempt to inhibit ..
  54. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2002
    ..The specific aims are to: 1a) Determine whether rhinovirus and respiratory syncytial virus (RSV), two viruses associated with human asthma activate PKR; b) By transfection ..
  55. ASTHMA AND ALLERGIC DISEASE CENTER GRANT
    William Busse; Fiscal Year: 1992
    ..with human leukocytes, parainfluenza-3 infected guinea pigs, and patients experimentally infected with rhinovirus, we hypothesize that a major mechanism for virus induced airway hyperresponsiveness is enhanced activity of ..
  56. IMMUNOGENICITY & STRUCTURES OF RHINOVIRUS-HIV CHIMERAS
    GAIL ARNOLD; Fiscal Year: 1999
    ....
  57. Rhinovirus accelerates wound repair via surface signaling EGFR activation
    Jonathan Koff; Fiscal Year: 2007
    ..b>Rhinovirus (RV) infection is responsible for exacerbations of several of these diseases...
  58. RHINOVIRUS REPLICONS AS VECTORS FOR MUCOSAL IMMUNIZATION
    STANLEY LEMON; Fiscal Year: 2000
    ..Specific Aim 4 is to the production of a replicon packaging system under GMP conditions in order to facilitate early phase I testing of candidate replicon vaccines in humans. ..
  59. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2002
    Upper respiratory infections due to rhinovirus have been shown to be the most common cause of asthma exacerbations in adults and children over the age of 2...
  60. Tetravalent Humanized Anti-ICAM for Rhinovirus Infection
    Fang Fang; Fiscal Year: 2001
    ..a high functional affinity antibody construct directed against ICAM-1 for the prevention and treatment of human rhinovirus (HRV) infections. Several multivalent, humanized antibody constructs will be expressed in E...
  61. Rhinoviruses, Epithelial Cells, and Airway Function
    Homer Boushey; Fiscal Year: 2004
    The goal of this application is to examine how rhinovirus (RV) infection induces worsening of asthma...
  62. IMMUNOGENICITY AND STRUCTURES OF RHINOVIRUS:HIV CHIMERAS
    GAIL ARNOLD; Fiscal Year: 2000
    ..HRV:HIV chimeras have the potential to serve as live-virus vaccine components, capable of stimulating humoral, mucosal and, perhaps, cell-mediated immune responses. ..