alpharetrovirus

Summary

Summary: A genus of the family RETROVIRIDAE with type C morphology, that causes malignant and other diseases in wild birds and domestic fowl.

Top Publications

  1. pmc Two retroviral entry pathways distinguished by lipid raft association of the viral receptor and differences in viral infectivity
    Shakti Narayan
    Cellular and Molecular Biology Program, Department of Oncology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 77:1977-83. 2003
  2. pmc Critical role for the cysteines flanking the internal fusion peptide of avian sarcoma/leukosis virus envelope glycoprotein
    S E Delos
    Department of Cell Biology, School of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Virol 74:9738-41. 2000
  3. pmc Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome
    Stephen D Barr
    University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 79:12035-44. 2005
  4. ncbi Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro
    Karen Moreau
    Universite Claude Bernard, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Lyon, France
    Eur J Biochem 270:4426-38. 2003
  5. pmc Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 82:3131-4. 2008
  6. ncbi Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization
    Karen Moreau
    Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Universite Claude Bernard, Lyon, France
    Virology 318:566-81. 2004
  7. ncbi Analysis of conserved and non-conserved amino acids critical for ALSV (Avian leukemia and sarcoma viruses) integrase functions in vitro
    K Moreau
    Centre de Genetique Moleculaire et Cellulaire, Institut National de la Recherche Agronomique, Universite Claude Bernard, Villeurbanne, France
    Arch Virol 147:1761-78. 2002
  8. ncbi Avian sarcoma and leukemia virus (ASLV) integration in vitro: mutation or deletion of integrase (IN) recognition sequences does not prevent but only reduces the efficiency and accuracy of DNA integration
    Karen Moreau
    Institut National de la Recherche Agronomique, UMR754, Lyon, F 69007, France
    Virology 392:94-102. 2009
  9. pmc Role of basic residues in the subgroup-determining region of the subgroup A avian sarcoma and leukosis virus envelope in receptor binding and infection
    L Rong
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Virol 71:3458-65. 1997
  10. pmc The avian retrovirus env gene family: molecular analysis of host range and antigenic variants
    C A Bova
    Department of Biochemistry, University of North Carolina, Chapel Hill 27599
    J Virol 62:75-83. 1988

Research Grants

Scientific Experts

  • Sue E Delos
  • Andrew B Allison
  • Jeffrey E Lee
  • Filip Senigl
  • Mark T McNally
  • Amelia Still
  • Mostafa Rajabzadeh
  • Kyung Mee Choi
  • E C Holland
  • Sandra Orsulic
  • B C Lewis
  • M Hartl
  • J Svoboda
  • Karen Moreau
  • Eric Johnson
  • Akihiro Ochi
  • Gérard Verdier
  • Corinne Ronfort
  • Claudine Faure
  • Markéta Reinisová
  • Caroline Torne-Celer
  • Sayuri Nakamura
  • John M Coffin
  • Kenji Ochiai
  • Takashi Umemura
  • John A T Young
  • Shakti Narayan
  • Masaaki Ono
  • Kerstin B Kaufmann
  • Martijn H Brugman
  • Christopher Baum
  • Yuji Sunden
  • Axel Schambach
  • Julia D Suerth
  • Allison Ballandras-Colas
  • Emily I C Nikolic
  • Chaonan Liu
  • Eleanor R Gray
  • Cornelius Bondzi
  • Jonathan P Stoye
  • Jiri Plachy
  • Josef Geryk
  • Jiri Hejnar
  • Eugene Valkov
  • R Damico
  • Gulnahar B Mortuza
  • Nolwenn Jouvenet
  • You Jung Kim
  • Mark J Federspiel
  • Carmen Butan
  • Stefan K Siwko
  • Virginie S Vervoort
  • Hitoshi Hatai
  • Barbara Seidler
  • Audelia Munguia
  • Heather L Wiegand
  • David Derse
  • Angeline Rose Babel
  • Kristin L Butterfield-Gerson
  • E S Johnson
  • G Jonah A Rainey
  • Alexander G Holman
  • Stephen D Barr
  • Lori F Maxfield
  • Vesco Mutskov
  • L Borisenko
  • Nikolajs Sjakste
  • Y Tomioka
  • Eun Gyung Lee
  • Sebastien Violot
  • R J O Barnard
  • A D Beniaminov
  • Amy L Harper
  • Igor Kanevsky
  • Kelly M McNagny
  • P Bates
  • K Zingler
  • A K Ghosh
  • K Moreau
  • Lioba Lobmayr
  • Sophie Snitkovsky
  • Hiroki Yabushita
  • Asumi Abe
  • Sayaka Kishi
  • Severina A La Rocca
  • P M Chesters
  • L Rong
  • Michael Rothe
  • Erik Serrao
  • Olga Kustikova

Detail Information

Publications148 found, 100 shown here

  1. pmc Two retroviral entry pathways distinguished by lipid raft association of the viral receptor and differences in viral infectivity
    Shakti Narayan
    Cellular and Molecular Biology Program, Department of Oncology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 77:1977-83. 2003
    ..The TVA800/ASLV-A system should prove useful for the molecular analysis of lipid raft-dependent endocytosis and may provide a tool for the biochemical dissection of the poorly understood uncoating step of retroviral replication...
  2. pmc Critical role for the cysteines flanking the internal fusion peptide of avian sarcoma/leukosis virus envelope glycoprotein
    S E Delos
    Department of Cell Biology, School of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Virol 74:9738-41. 2000
    ..The fusion peptide of the Ebola virus GP glycoprotein may conform to a similar structure...
  3. pmc Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome
    Stephen D Barr
    University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 79:12035-44. 2005
    ..Further analysis indicated that ERVs in humans, mice, and rats showed similar distributions, suggesting purifying selection dictated their distributions as well...
  4. ncbi Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro
    Karen Moreau
    Universite Claude Bernard, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Lyon, France
    Eur J Biochem 270:4426-38. 2003
    ..This study points to the important role of residues at the IN C-terminal domain in the folding and dimerization of the enzyme as well as in the concerted DNA integration of viral DNA ends...
  5. pmc Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 82:3131-4. 2008
    ..These findings indicate that the cysteines flanking the internal fusion peptide of EnvA (and perhaps by analogy Ebola virus glycoprotein) are important for the foldback stage of the conformational changes that lead to membrane merger...
  6. ncbi Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization
    Karen Moreau
    Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Universite Claude Bernard, Lyon, France
    Virology 318:566-81. 2004
    ..This study points to the important role of core domain residues in the concerted integration of viral DNA ends as well as in the oligomerization of the enzyme...
  7. ncbi Analysis of conserved and non-conserved amino acids critical for ALSV (Avian leukemia and sarcoma viruses) integrase functions in vitro
    K Moreau
    Centre de Genetique Moleculaire et Cellulaire, Institut National de la Recherche Agronomique, Universite Claude Bernard, Villeurbanne, France
    Arch Virol 147:1761-78. 2002
    ..Finally, for some mutations, we observed differences between the ALSV and HIV (Human immunodeficiency virus) IN corresponding residues...
  8. ncbi Avian sarcoma and leukemia virus (ASLV) integration in vitro: mutation or deletion of integrase (IN) recognition sequences does not prevent but only reduces the efficiency and accuracy of DNA integration
    Karen Moreau
    Institut National de la Recherche Agronomique, UMR754, Lyon, F 69007, France
    Virology 392:94-102. 2009
    ..However, efficiency and accuracy (i.e. fidelity of size duplication and of end cleavage) of integration were reduced...
  9. pmc Role of basic residues in the subgroup-determining region of the subgroup A avian sarcoma and leukosis virus envelope in receptor binding and infection
    L Rong
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Virol 71:3458-65. 1997
    ..These results demonstrate that the basic residues in the ASLV envelope have roles in both receptor recognition and post-receptor binding events during viral entry...
  10. pmc The avian retrovirus env gene family: molecular analysis of host range and antigenic variants
    C A Bova
    Department of Biochemistry, University of North Carolina, Chapel Hill 27599
    J Virol 62:75-83. 1988
    ..Using a molecular recombinant, we demonstrated that type-specific neutralization of two subgroup A viruses was associated with the gp85-coding domain of the virus...
  11. ncbi Alpharetrovirus envelope-receptor interactions
    R J O Barnard
    McArdle Laboratories for Cancer Research, Department of Oncology, University of Wisconsin Madison, 1400 University Ave, Madison, WI 53706, USA
    Curr Top Microbiol Immunol 281:107-36. 2003
    ..However, recent work has indicated that the alpharetrovirus, avian sarcoma and leukosis virus (ASLV), utilizes a novel entry mechanism that combines aspects of both pH-..
  12. ncbi The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors
    J Schaefer-Klein
    Molecular Medicine Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, 55905, USA
    Virology 248:305-11. 1998
    ..The cell line responds appropriately to the expression of a transforming oncogene (v-myc) to a growth suppressor gene [p21(waf1)] and can be sorted (using FACS) if infected by an ASLV vector that expresses GFP...
  13. pmc Mutational analysis of the candidate internal fusion peptide of the avian leukosis and sarcoma virus subgroup A envelope glycoprotein
    L D Hernandez
    Department of Biochemistry, University of California, San Francisco 94143, USA
    J Virol 72:3259-67. 1998
    ..Furthermore, none of the mutants displayed activity in a cell-cell fusion assay. Our results support the contention that residues 21 to 42 of ALSV subgroup A Env constitute its fusion peptide...
  14. ncbi Selection of a subgroup A avian leukosis virus [ALV(A)] envelope resistant to soluble ALV(A) surface glycoprotein
    S L Holmen
    Molecular Medicine Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Virology 273:364-73. 2000
    ..This virus had a six-amino-acid deletion in the subgroup A hr1 that altered receptor usage. This approach may identify regions of SU that play a critical role in receptor specificity...
  15. pmc The central proline of an internal viral fusion peptide serves two important roles
    S E Delos
    Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville, Virginia 22908, USA
    J Virol 74:1686-93. 2000
    ..Our findings suggest that the central proline in the ASLV fusion peptide is important for the formation of the native (metastable) Env structure as well as for membrane interactions that lead to fusion...
  16. pmc Substitutions in the receptor-binding domain of the avian sarcoma and leukosis virus envelope uncouple receptor-triggered structural rearrangements in the surface and transmembrane subunits
    R Damico
    Department of Microbiology, Graduate Program in Cellular and Molecular Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6076, USA
    J Virol 73:3087-94. 1999
    ..Analysis of these mutants continues earlier observations that binding to the cellular receptor provides the trigger for efficient activation of this pH-independent viral envelope protein...
  17. pmc Evolution of broad host range in retroviruses leads to cell death mediated by highly cytopathic variants
    G Jonah A Rainey
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA, USA
    J Virol 80:562-70. 2006
    ..Here, we show that mutants of a subgroup B avian retrovirus (Alpharetrovirus) cause a very dramatic CPE in certain susceptible avian cells that is coincident with elevated levels of ..
  18. pmc Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other
    N Miyajima
    Institute of Medical Science, University of Tokyo, Japan
    Nucleic Acids Res 16:11057-74. 1988
    ..Hybridization analysis of DNAs from sorted chromosomes shows that the ear-2 gene is located on chromosome 19 and ear-3 on chromosome 5, indicating that the two genes are clearly different from each other...
  19. pmc Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites
    Alexander G Holman
    Department of Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 102:6103-7. 2005
    ....
  20. ncbi An epizootic of subcutaneous tumors associated with subgroup A avian leukosis/sarcoma virus in young layer chickens
    Masaaki Ono
    JA Zen noh National Federation of Agricultural Cooperative Associations, Institute of Animal Health, 7 Ohja machi, Sakura, Chiba 285 0043, Japan
    Avian Dis 48:940-6. 2004
    ..The virus was isolated from the tumors. Seventeen of 20 clinically normal chickens in the affected flock showed antibodies against ALSV. These results suggest that subcutaneous tumors are associated with subgroup A ALSV infection...
  21. pmc Relationship between retroviral DNA-integration-site selection and host cell transcription
    Lori F Maxfield
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 102:1436-41. 2005
    ..Last, transcription might lead to remodeling of chromatin into a structure that is less favorable for integration...
  22. ncbi Site-specific excision or protection of an alpha A globin gene genomic site in apoptotic transformed chicken erythroblasts
    Nikolajs Sjakste
    Faculty of Medicine of the University of Latvia, Sharlotes Street 1a, Riga LV1001, Latvia
    Cell Mol Biol Lett 9:429-37. 2004
    ..Transcription of the non-erythroid NIK gene, transcribed in the upstream part of the domain, did not depend on the level of apoptotic DNA fragmentation...
  23. pmc In vitro characterization of a base pairing interaction between the primer binding site and the minimal packaging signal of avian leukosis virus genomic RNA
    Igor Kanevsky
    Unité Mixte de Recherche 8113 du CNRS, LBPA Alembert, Ecole Normale Superieure de Cachan, 94235 Cachan Cedex, France
    Nucleic Acids Res 31:7070-82. 2003
    ..Interestingly, we found that in other retroviruses the PBS sequence can also base pair with a terminal loop of the stem-loops involved in RNA packaging...
  24. pmc A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor
    A Baniahmad
    Max Planck Institut fur Biochemie, Genzentrum, Martinsried, FRG
    EMBO J 11:1015-23. 1992
    ..However, the activity of this domain can be neutralized by an additional domain in the C-terminus which functions cell specifically...
  25. pmc Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product
    D K Watson
    Proc Natl Acad Sci U S A 80:3642-5. 1983
    ..In the latter domain, the amino acid variation between v-myc and chicken c-myc is less than 2%, whereas that between the chicken v-myc and the human is 27%, with the variation concentrated in the region that flanks the splicing points...
  26. ncbi A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature
    Virginie S Vervoort
    Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Transgenic Res 17:403-15. 2008
    ..The Flk1-TVA mouse model in conjunction with the RCAS gene delivery system will be useful to study molecular mechanisms underlying adult forms of angiogenesis...
  27. ncbi Primary structure and expression of a chicken cDNA encoding a protein with zinc-finger motifs
    A Benn
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, F R G
    Gene 106:207-12. 1991
    ..At day 4 of embryonic development strong cKr1 hybridization signals are found in the brain and neural tube, in the mesonephros and in the gut, respectively...
  28. ncbi Targeting retroviral vector infection to cells that express heregulin receptors using a TVA-heregulin bridge protein
    Sophie Snitkovsky
    Massachussetts Institute of Technology, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Virology 292:150-5. 2002
    ..These data confirm that the GATE protein TVA-herbeta1 mediates targeted retroviral infection via cell surface heregulin receptors...
  29. pmc Efficient subgroup C avian sarcoma and leukosis virus receptor activity requires the IgV domain of the Tvc receptor and proper display on the cell membrane
    Audelia Munguia
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Virol 82:11419-28. 2008
    ....
  30. ncbi E26 leukemia virus converts primitive erythroid cells into cycling multilineage progenitors
    Kelly M McNagny
    Biomedical Research Centre, Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Blood 101:1103-10. 2003
    ..These results suggest that the Myb-Ets oncoprotein of the E26 leukemia virus converts primitive erythroid cells into proliferating definitive-type multipotent hematopoietic progenitors...
  31. ncbi An RCAS-TVA-based approach to designer mouse models
    Sandra Orsulic
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mamm Genome 13:543-7. 2002
  32. ncbi Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene
    B Debuire
    Science 224:1456-9. 1984
    ..A src-related oncogene such as erbB in synergy with an activated specific cell-derived gene such as erbA can profoundly affect early erythroid differentiation...
  33. ncbi A common onc gene sequence transduced by avian carcinoma virus MH2 and by murine sarcoma virus 3611
    N C Kan
    Science 223:813-6. 1984
    ..The difference in transformation capabilities of MH2 and MSV 3611 serves as an example...
  34. pmc Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:1218-23. 1998
    ..With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors...
  35. pmc A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo
    Markéta Reinisová
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 14220 Prague 4, Czech Republic
    J Virol 82:2097-105. 2008
    ..These are the first results that demonstrate a possible role of the cysteine-rich domain 3 in the function of the Tvb receptors...
  36. pmc The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active
    D K Watson
    Proc Natl Acad Sci U S A 82:7294-8. 1985
    ..Thus, the tripartite transforming gene of E26 includes four distinct domains that may be functionally relevant for the transforming function of the virus (delta gag, myb, ets-1, and ets-2)...
  37. ncbi Selective repression of myoD transcription by v-Myc prevents terminal differentiation of quail embryo myoblasts transformed by the MC29 strain of avian myelocytomatosis virus
    Severina A La Rocca
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Biologia Cellulare e dello Sviluppo, Sezione di Scienze Microbiologiche, Universita di Roma La Sapienza, 00185 Roma, Italy
    Oncogene 21:4838-42. 2002
    ..These data suggest that transcriptional repression of qmyoD is a major and rate-limiting step in the molecular pathway by which v-Myc severely inhibits terminal differentiation in myogenic cells...
  38. ncbi Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
    A D Levinson
    Cell 15:561-72. 1978
    ..These findings raise the possibility that phosphorylation of specific cellular targets might account for transformation of the host cell by src...
  39. pmc Protein kinase activity associated with the avian sarcoma virus src gene product
    M S Collett
    Proc Natl Acad Sci U S A 75:2021-4. 1978
    ..These results on an enzymatic activity associated with the ASV transforming protein are discussed in terms of protein phosphorylation as a mechanism for viral transformation...
  40. ncbi Molecular analysis of endogenous avian leukosis/sarcoma virus genomes in Korean chicken embryos
    You Jung Kim
    Bio therapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Japan
    J Vet Med Sci 70:17-23. 2008
    ..These results are expected to provide useful information for the control and establishment of a surveillance system for endogenous ALSVs in Korea...
  41. pmc A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors
    Barbara Seidler
    Department of Internal Medicine 2, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 105:10137-42. 2008
    ....
  42. ncbi Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product
    C Weinberger
    Nature 318:670-2. 1985
    ..This suggests a mechanism by which transacting factors may facilitate transformation. We also identify a short region of hGR that is homologous with the Drosophila homoeotic proteins encoded by Antennapedia and fushi tarazu...
  43. ncbi Oncogenic retroviruses of cattle, chickens and turkeys: potential infectivity and oncogenicity for humans
    E S Johnson
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Med Hypotheses 46:354-6. 1996
    ..There is now urgent need to investigate this, particularly because recent epidemiological studies consistently demonstrate excess of cancers in groups occupationally exposed to these viruses...
  44. ncbi Structure of the capsid amino-terminal domain from the betaretrovirus, Jaagsiekte sheep retrovirus
    Gulnahar B Mortuza
    Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Mol Biol 386:1179-92. 2009
    ..We find that the structure is remarkably similar to the amino-terminal domain of the alpharetrovirus, avian leukosis virus, revealing a previously undetected evolutionary similarity...
  45. ncbi Detection of antibodies to avian leukosis/sarcoma viruses (ALSV) and reticuloendotheliosis viruses (REV) in humans by ELISA
    E S Johnson
    Environmental and Molecular Epidemiology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Cancer Detect Prev 19:394-404. 1995
    ..However, definitive tests such as Western Blot analyses are needed to confirm whether indeed antibodies to these viruses were specifically elicited in human sera...
  46. ncbi Detection of antibodies to avian leukosis/sarcoma viruses and reticuloendotheliosis viruses in humans by western blot assay
    E S Johnson
    Environmental and Molecular Epidemiology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Cancer Detect Prev 19:472-86. 1995
    ..The significance of this is not known. Further investigation into whether these findings mean that virus has been integrated into the human genome is needed, to assess the public health implications of these results...
  47. pmc Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin
    Nolwenn Jouvenet
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, USA
    J Virol 83:1837-44. 2009
    ..using the major structural proteins of a variety of prototype retroviruses, including members of the alpharetrovirus, betaretrovirus, deltaretrovirus, lentivirus, and spumaretrovirus families...
  48. pmc Analysis of the N-terminal region of the murine leukemia virus nucleocapsid protein
    Amelia Still
    Department of Biochemistry, University of Wisconsin, United States
    Virus Res 155:181-8. 2011
    ..These results suggest that the alpharetrovirus and lentivirus assembly elements either are not needed for gammaretroviruses, or are replaced by an ..
  49. ncbi Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia
    M M Le Beau
    Cancer Genet Cytogenet 23:269-74. 1986
    ..Another protooncogene, c-mos, is also retained at the conserved junction, suggesting that one or both of these genes may play a role in the pathogenesis of acute myelogenous leukemia...
  50. pmc RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis
    Carmen Butan
    Laboratory of Structural Biology, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 376:1168-81. 2008
    We used cryo-electron tomography to visualize Rous sarcoma virus, the prototypic alpharetrovirus. Its polyprotein Gag assembles into spherical procapsids, concomitant with budding...
  51. pmc Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man
    B U Zabel
    Proc Natl Acad Sci U S A 81:4874-8. 1984
    ..We found c-erb-A sequences on human chromosome 17 (17p11----qter) and located c-erb-B on human chromosome 7 (7pter----q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11...
  52. ncbi Assignment of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) to human chromosome band 17q21.1 by in situ hybridization
    M Muleris
    Institut Curie CNRS UMR 147, Paris, France
    Cytogenet Cell Genet 76:34-5. 1997
  53. pmc RNA processing control in avian retroviruses
    Mark T McNally
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Front Biosci 13:3869-83. 2008
    ..Retroviruses have served as important models to study RNA processing and this review summarizes a body of work using avian retroviruses that has led to the discovery of novel RNA splicing and polyadenylation control mechanisms...
  54. pmc Modulation of ribosomal frameshifting frequency and its effect on the replication of Rous sarcoma virus
    Emily I C Nikolic
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Virol 86:11581-94. 2012
    ..can be modulated before virus replication is compromised, and we have addressed this question using the alpharetrovirus Rous sarcoma virus (RSV) as a model system...
  55. ncbi Development of a flexible and specific gene delivery system for production of murine tumor models
    G H Fisher
    Varmus Lab, NIH NCI DBS, 49 Convent Drive, Building 49, 4A56, Bethesda, Maryland 20892, USA
    Oncogene 18:5253-60. 1999
    ..We discuss the theoretical and practical aspects of using recombinant avian retroviruses with TVA transgenic mice to generate cancer models...
  56. pmc Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples
    Martijn H Brugman
    Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany
    Hum Gene Ther Methods 24:68-79. 2013
    ..The crucial variables causing this variation need to be defined and methodological improvements are required to establish pyrosequencing reads as a quantification measure in polyclonal situations...
  57. pmc Cardiac pathology and molecular epidemiology by avian leukosis viruses in Japan
    Sayuri Nakamura
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS ONE 9:e86546. 2014
    ..native fowls infected with subgroup A of the avian leukosis viruses (ALVs-A), which belong to the genus Alpharetrovirus of the family Retroviridae and mainly induce lymphoid neoplasm in chickens...
  58. pmc Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen?
    Andrew B Allison
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA Electronic address
    Virology 450:2-12. 2014
    ..However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown. ..
  59. pmc Soluble receptor-induced retroviral infection of receptor-deficient cells
    R Damico
    Department of Microbiology, Graduate Program in Cellular and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    J Virol 74:6469-75. 2000
    ..These results demonstrate that receptor binding can activate the ASLV-A envelope protein and convert it to a fusogenic conformation competent to mediate the fusion of the viral and cellular membranes...
  60. ncbi Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma
    Akihiro Ochi
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Avian Dis 56:35-43. 2012
    ..Additionally, experimental infection revealed that CTS_5371 induced the proliferation of Schwann cells and perineurial cells. These results suggest that this ALV strain has the ability to induce PNSTs in chickens...
  61. ncbi Detection and molecular characterization of recombinant avian leukosis viruses in commercial egg-type chickens in China
    Chaonan Liu
    Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, 150001, P R China
    Avian Pathol 40:269-75. 2011
    ..The two recombinant viruses presented typical genetic organization of replication-competent genus Alpharetrovirus, and the gag and pol genes were well conserved with those of ALVs...
  62. pmc Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins
    Heather L Wiegand
    Center for Virology and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 81:13694-9. 2007
    ..Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins...
  63. ncbi [The role of structural elements in dimerization of RNA fragments in avian retroviruses]
    A D Beniaminov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
    Mol Biol (Mosk) 37:522-33. 2003
    ..Alternative structures and conformational transitions in RNA dimerization mechanisms in avian retroviruses are discussed...
  64. pmc The hr1 and fusion peptide regions of the subgroup B avian sarcoma and leukosis virus envelope glycoprotein influence low pH-dependent membrane fusion
    Angeline Rose Babel
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 2:e171. 2007
    ..These data indicate that these two regions of EnvB can influence the pH threshold of fusion activation...
  65. ncbi A recombinant avian leukosis virus associated with fowl glioma in layer chickens in Japan
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Avian Pathol 37:127-37. 2008
    ....
  66. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
    ..Induction of both LL and ML by the two chimeric viruses occurred through the activation of c-myc, while the EB tumours were induced by activation of the c-erbB oncogene...
  67. pmc Basic residues of the retroviral nucleocapsid play different roles in gag-gag and Gag-Psi RNA interactions
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 78:8486-95. 2004
    ..We used the yeast two-hybrid system to analyze the role of Alpharetrovirus NC in Gag-Gag interactions and also examined the efficiency of viral assembly and release in vivo...
  68. pmc Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9
    Vesco Mutskov
    Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA
    EMBO J 23:138-49. 2004
    ..We show that the kinetics of silencing exclude histone H3 K9 and promoter DNA methylation as the primary causative events in our transgene system...
  69. ncbi An improved self-deleting retroviral vector derived from avian leukemia and sarcoma virus
    Caroline Torne-Celer
    Universite de Lyon, Lyon, France
    Arch Virol 153:2233-43. 2008
    ..The inactivation procedure achieved here might improve the biosafety of retroviral vectors...
  70. ncbi [The myc oncogene and transdifferentiation of the retinal pigment epithelium]
    J S Beche-Belsot
    CNRS IC UMR 146, Institut Curie Recherche Bâtiment 110, Centre Universitaire 91405 Orsay
    J Soc Biol 195:107-13. 2001
    ..Mitf is expressed in the entire optic cup, later restricted to the pigmented retina. Mitf is involved in the regulation of the pigmented differentiation. We conclude that v-myc can reverse the RPE to the bipotential retinal primordia...
  71. pmc Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors
    Stefan K Siwko
    Breast Center, Baylor College of Medicine, Houston, TX, 77030 USA
    Neoplasia 10:653-62, 1 p following 662. 2008
    ..This work demonstrates the first use of a lentiviral vector to introduce oncogenes for modeling cancer in mice, and this vector system may be especially suitable for introducing genetic alterations into quiescent cells in vivo...
  72. ncbi Avian erythroblastosis: a model system to study oncogene co-operation in leukemia
    M J Hayman
    Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794
    Cancer Surv 15:53-68. 1992
    ..Thus, the avian leukaemia virus model has taught us important lessons that will help us to understand the basic molecular mechanisms that give rise to human leukaemia...
  73. pmc Sequence-specific DNA binding by the v-erbA oncogene protein of avian erythroblastosis virus
    B G Bonde
    Department of Microbiology, University of California, Davis 95616
    J Virol 64:1314-20. 1990
    ....
  74. pmc Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation
    S Massoglia
    Department of Developmental Biology, Genentech, Inc, South San Francisco, California 94080
    Mol Cell Biol 10:3048-55. 1990
    ..These findings provide new insight into the mechanism of receptor-mediated signal transduction and suggest a novel alternative for subversion of cellular control mechanisms and proto-oncogene activation...
  75. pmc v-erbA acts on retinoic acid receptors in immature avian erythroid cells
    S Sande
    Department of Microbiology, University of California, Davis 95616
    J Virol 67:1067-74. 1993
    ..These results are consistent with our hypothesis that v-erbA can act in neoplasia by interfering with a retinoic acid-mediated signal transduction pathway...
  76. ncbi v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (band 3) gene
    M Zenke
    European Molecular Biology Laboratory Differentiation Program, Heidelberg, Federal Republic of Germany
    Cell 52:107-19. 1988
    ..Additional evidence obtained with an inhibitor of band 3 activity suggests that the v-erbA-induced inhibition of band 3 gene expression is at least partly responsible for the differentiation block caused by this oncogene...
  77. ncbi The mutated, myeloid cell-specific growth factor receptor v-fms transforms avian erythroid but not myeloid cells
    U Fuhrmann
    European Molecular Biology Laboratory, Heidelberg, FRG
    Genes Dev 3:2072-82. 1989
    ..Unlike the other tyrosine kinases, v-fms did not induce cMGF secretion in myb-myeloblasts, suggesting a nonautocrine mechanism of growth factor independence...
  78. pmc Genetic dissection of functional domains within the avian erythroblastosis virus v-erbA oncogene
    M L Privalsky
    Department of Microbiology, University of California, Davis 95616
    Mol Cell Biol 8:4510-7. 1988
    ....
  79. ncbi [Oncogenes and the origin of leukemia. Acute avian leukemia viruses]
    T Graf
    Europäischen Laboratorium für Molekularbiologie, Heidelberg
    Arzneimittelforschung 38:454-60. 1988
    ..It will be interesting to determine whether the type of mechanisms of oncogene cooperativity elucidated for acute leukemia viruses are also operative during leukemogenesis in humans...
  80. pmc Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector
    S Fuerstenberg
    Department of Molecular Biology, Karolinska Institute, Stockholm, Sweden
    J Virol 64:5891-902. 1990
    ..The ectopic expression of band 3 protein provides a visual marker for vector function in these cells...
  81. pmc Reverse transcriptase activity in chicken embryo fibroblast culture supernatants is associated with particles containing endogenous avian retrovirus EAV-0 RNA
    R N Weissmahr
    Swiss National Center for Retroviruses, University of Zurich
    J Virol 71:3005-12. 1997
    ..Furthermore, complexes of naturally primed EAV-0(B1) RNA with RT were demonstrated. Taken together, these data strongly suggest that EAV-0 is able to produce virus-like particles with an active RT...
  82. ncbi v-erbB oncogene expression accounts for most variations in protein synthesis after avian erythroblastosis virus infection of chicken embryo fibroblasts: a two-dimensional electrophoresis study
    C Desbois
    Immuno Virologie Moleculaire et Cellulaire, Universite Claude Bernard, CNRS UMR 30, Faculte de Medicine Alexis Carrel, Lyon, France
    Electrophoresis 13:383-8. 1992
    ..Moreover, the deregulation of protein synthesis by v-erbB-expressing viruses was correlated with the morphological transformation state of cells...
  83. pmc Gelsolin is expressed in early erythroid progenitor cells and negatively regulated during erythropoiesis
    H Hinssen
    Division of Biology, California Institute of Technology, Pasadena 91125
    J Cell Biol 105:1425-33. 1987
    ....
  84. ncbi Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase
    A J Crowe
    Department of Microbiology, State University of New York, Stony Brook 11794 5222
    Oncogene 9:537-44. 1994
    ..These observations make the phosphorylation of the shc proteins a good candidate for being involved in oncogenic signaling by the env-sea oncoprotein...
  85. ncbi Oncogenes related to growth factor receptors
    K Toyoshima
    Institute of Medical Science, University of Tokyo, Japan
    Acta Neurochir Suppl (Wien) 41:110-7. 1987
    ..Members of each subgroup appeared to be originated from each single ancestral gene during evolutionary process even within the protein kinase super family...
  86. ncbi Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts
    B E Moore
    Department of Microbiology, University of Texas at Austin 78712 1095
    Virology 162:377-87. 1988
    ....
  87. pmc Role of oligomerization of the S13 Env-Sea oncoprotein in cell transformation
    A M Morimoto
    Department of Microbiology, State University of New York at Stony Brook, 11794 5222
    J Virol 68:1837-42. 1994
    ..These results suggest that oligomerization, transport, and intracellular localization represent levels at which the oncogenic activity of the Env-Sea oncoprotein may be regulated...
  88. pmc An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA
    Amy L Harper
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Virol 77:3838-45. 2003
    ..We have now extended these findings to the integrases of a nonprimate lentivirus and a more distantly related alpharetrovirus. We found that substitutions at the analogous positions in visna virus integrase and Rous sarcoma virus ..
  89. pmc Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site
    Filip Senigl
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic
    Nucleic Acids Res 40:5298-312. 2012
    ..These findings indicate that the epigenomic features of integration sites are crucial for their permissivity to the proviral expression...
  90. pmc Biochemical characterization of novel retroviral integrase proteins
    Allison Ballandras-Colas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e76638. 2013
    ..Here, we characterize five previously unstudied integrase proteins, including those derived from the alpharetrovirus lymphoproliferative disease virus (LPDV), betaretroviruses Jaagsiekte sheep retrovirus (JSRV), and mouse ..
  91. pmc Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing
    Kerstin B Kaufmann
    Institute for Biomedical Research, Georg Speyer Haus, Frankfurt, Germany
    Mol Ther 21:648-61. 2013
    ..Taken together, this highlights the potential of this SIN alpharetroviral system as a platform for new candidate vectors for future gene therapy of hematopoietic disorders...
  92. pmc Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A
    Markéta Reinisová
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Virol 86:2021-30. 2012
    ..We identified defective splicing to be a mechanism of resistance to ASLV and conclude that such a type of mutation could play an important role in virus-host coevolution...
  93. pmc Binding of more than one Tva800 molecule is required for ASLV-A entry
    Eleanor R Gray
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Retrovirology 8:96. 2011
    ..In these studies, we have now investigated the number of target receptors necessary for entry of ASLV Env-pseudotyped virions...
  94. ncbi Industrial hygiene assessment of reticuloendotheliosis viruses exposure in the poultry industry
    Kyung Mee Choi
    Department of Environmental and Occupational Health Sciences, University of North Texas, Health Science Center, School of Public Health, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Int Arch Occup Environ Health 84:375-82. 2011
    ..The objectives of this study are to examine whether a similar association can be found with REV antibody levels and to examine the correlation between REV and ALSV antibody levels...
  95. ncbi Cooperative cell transformation by Myc/Mil(Raf) involves induction of AP-1 and activation of genes implicated in cell motility and metastasis
    M Hartl
    Institute of Biochemistry and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innsbruck, Austria
    Oncogene 25:4043-55. 2006
    ....
  96. ncbi Identification of two additional v-sea-encoded proteins in avian erythroblastosis virus, S13-infected fibroblasts
    J Knight
    Department of Microbiology, State University of New York, Stony Brook 11794
    Virology 178:232-7. 1990
    ..Possible mechanisms for the biosynthesis of these two new proteins are discussed...
  97. ncbi Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation
    S Selmi
    Division of Molecular Endocrinology, New York University School of Medicine, New York 10016
    J Biol Chem 266:11589-93. 1991
    ..Introduction of this Pro to Ser change into DBD- c-erbA resulted in a protein which was inactive both functionally and in blocking receptor dimer formation in vitro...
  98. ncbi A transcription-dependent DNase I-hypersensitive site in a far upstream segment of the chicken alpha-globin gene domain coincides with a matrix attachment region
    C V De Moura Gallo
    Institut Jacques Monod, Universite Paris 7, France
    Biochem Biophys Res Commun 184:1226-34. 1992
    ..A matrix attachment region (MAR) has also been found in the same subfragment, suggesting that it may be involved in the control of transcription of the chicken alpha-globin genes...
  99. pmc Studies of the "chain reversal regions" of the avian sarcoma/leukosis virus (ASLV) and ebolavirus fusion proteins: analogous residues are important, and a His residue unique to EnvA affects the pH dependence of ASLV entry
    Sue E Delos
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 84:5687-94. 2010
    ..We further found that a His residue that is unique to the chain reversal region of ASLV EnvA controls the pH at which ASLV entry occurs...
  100. pmc Avian sarcoma-leukosis virus pol-endo proteins expressed independently in mammalian cells accumulate in the nucleus but can be directed to other cellular compartments
    C Morris-Vasios
    Department of Molecular Oncology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    J Virol 62:349-53. 1988
    ..These and derivative vectors will make it possible to assess the consequence of retroviral pol gene expression in eucaryotic cells...
  101. pmc The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family
    D R Smith
    Imperial Cancer Research Fund Laboratories, Lincolns Inn Fields, London, England
    Proc Natl Acad Sci U S A 86:5291-5. 1989
    ..Sequence comparisons revealed that the v-sea gene was most closely related to the insulin receptor family of protein-tyrosine kinases, the greatest similarity being with the human MET oncogene...

Research Grants1

  1. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
    ..The confirmed demonstration of ALSV pro-viral DNA in the genome of exposed tumor samples but not in that of control tumor samples, will provide definitive evidence incriminating ALSV in human carcinogenesis. ..