premature infant


Summary: A human infant born before 37 weeks of GESTATION.

Top Publications

  1. ncbi Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis
    Adnan T Bhutta
    Department of Pediatrics, Arkansas University for Medical Sciences, Little Rock, USA
    JAMA 288:728-37. 2002
  2. ncbi Neurodevelopmental outcome of the premature infant
    Bonnie E Stephens
    Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Pediatr Clin North Am 56:631-46, Table of Contents. 2009
  3. ncbi Neurologic and developmental disability at six years of age after extremely preterm birth
    Neil Marlow
    School of Human Development, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:9-19. 2005
  4. ncbi Abnormal cerebral structure is present at term in premature infants
    Terrie E Inder
    Murdoch Children s Research Institute, Royal Women s Hospital, University of Melbourne, Melbourne, Australia
    Pediatrics 115:286-94. 2005
  5. ncbi A new and improved population-based Canadian reference for birth weight for gestational age
    M S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Canada
    Pediatrics 108:E35. 2001
  6. ncbi Outcomes in young adulthood for very-low-birth-weight infants
    Maureen Hack
    Department of Pediatrics, Case Western Reserve University, Cleveland, USA
    N Engl J Med 346:149-57. 2002
  7. ncbi Neurobiology of periventricular leukomalacia in the premature infant
    J J Volpe
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 50:553-62. 2001
  8. ncbi Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants
    Bradley S Peterson
    Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 111:939-48. 2003
  9. pmc Mycoplasmas and ureaplasmas as neonatal pathogens
    Ken B Waites
    Department of Pathology, University of Alabama, Birmingham, Alabama 35249, USA
    Clin Microbiol Rev 18:757-89. 2005
  10. ncbi Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms
    Barbara Schmidt
    Department of Pediatrics, McMaster University, HSC 3N11E, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 289:1124-9. 2003

Detail Information

Publications370 found, 100 shown here

  1. ncbi Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis
    Adnan T Bhutta
    Department of Pediatrics, Arkansas University for Medical Sciences, Little Rock, USA
    JAMA 288:728-37. 2002
    ..The cognitive and behavioral outcomes of school-aged children who were born preterm have been reported extensively. Many of these studies have methodological flaws that preclude an accurate estimate of the long-term outcomes of prematurity...
  2. ncbi Neurodevelopmental outcome of the premature infant
    Bonnie E Stephens
    Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Pediatr Clin North Am 56:631-46, Table of Contents. 2009
    ..There is now increasing evidence of sustained adverse outcomes into school age and adolescence, not only for ELBW infants but for infants born late preterm...
  3. ncbi Neurologic and developmental disability at six years of age after extremely preterm birth
    Neil Marlow
    School of Human Development, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:9-19. 2005
    ..Birth before 26 weeks of gestation is associated with a high prevalence of neurologic and developmental disabilities in the infant during the first two years of life...
  4. ncbi Abnormal cerebral structure is present at term in premature infants
    Terrie E Inder
    Murdoch Children s Research Institute, Royal Women s Hospital, University of Melbourne, Melbourne, Australia
    Pediatrics 115:286-94. 2005
    ..However, there is a limited understanding of the nature of the cerebral abnormality underlying these adverse neurologic outcomes...
  5. ncbi A new and improved population-based Canadian reference for birth weight for gestational age
    M S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Canada
    Pediatrics 108:E35. 2001
  6. ncbi Outcomes in young adulthood for very-low-birth-weight infants
    Maureen Hack
    Department of Pediatrics, Case Western Reserve University, Cleveland, USA
    N Engl J Med 346:149-57. 2002
    ..Very-low-birth-weight infants (those weighing less than 1500 g) born during the initial years of neonatal intensive care have now reached young adulthood...
  7. ncbi Neurobiology of periventricular leukomalacia in the premature infant
    J J Volpe
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 50:553-62. 2001
    Brain injury in the premature infant is a problem of enormous importance...
  8. ncbi Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants
    Bradley S Peterson
    Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 111:939-48. 2003
    ..To compare regional brain volumes measured in term and preterm infants, and to correlate regional volumes with measures of neurodevelopmental outcome...
  9. pmc Mycoplasmas and ureaplasmas as neonatal pathogens
    Ken B Waites
    Department of Pathology, University of Alabama, Birmingham, Alabama 35249, USA
    Clin Microbiol Rev 18:757-89. 2005
  10. ncbi Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms
    Barbara Schmidt
    Department of Pediatrics, McMaster University, HSC 3N11E, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 289:1124-9. 2003
    ..Despite more than 2 decades of outcomes research after very preterm birth, clinicians remain uncertain about the extent to which neonatal morbidities predict poor long-term outcomes of extremely low-birth-weight (ELBW) infants...
  11. pmc Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Child Neurol 24:1085-104. 2009
    ..appears to be especially common and relates to a particular vulnerability of the cerebellum of the small premature infant. Central to this vulnerability are the extraordinarily rapid and complex developmental events occurring in ..
  12. ncbi Preterm delivery
    Michael M Slattery
    Department of Obstetrics and Gynaecology, National University of Ireland Galway, Clinical Science Institute, University College Hospital Galway, Galway, Ireland
    Lancet 360:1489-97. 2002
    ..The continuing elucidation of the mechanisms that regulate preterm labour, combined with rigorous clinical assessment, offer hope for future solutions...
  13. ncbi Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia
    Rita M Ryan
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Buffalo, NY, USA
    Clin Rev Allergy Immunol 34:174-90. 2008
  14. ncbi Academic attainment and special educational needs in extremely preterm children at 11 years of age: the EPICure study
    S Johnson
    Institute for Women s Health, University College, 286 96 Chenies Mews, London WC1E 6HX, UK
    Arch Dis Child Fetal Neonatal Ed 94:F283-9. 2009
    ..To assess academic attainment and special educational needs (SEN) in extremely preterm children in middle childhood...
  15. ncbi Longitudinal growth of hospitalized very low birth weight infants
    R A Ehrenkranz
    Yale University, New Haven, Connecticut, USA
    Pediatrics 104:280-9. 1999
    ..The interpretation of growth rates for very low birth weight infants is obscured by limited data, recent changes in perinatal care, and the uncertain effects of multiple therapies...
  16. ncbi Factors affecting low birthweight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection
    W Shih
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
    Hum Reprod 23:1644-53. 2008
    ..Factors associated with low birthweight (LBW) after assisted reproduction technology (ART) were studied...
  17. ncbi The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis
    Rahul J Anand
    Division of Pediatric Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Shock 27:124-33. 2007
    ..This review will serve to provide an overview of recent evidence regarding the components of the intestinal barrier, and the mechanisms by which disruptions in barrier function may contribute to the pathogenesis of NEC...
  18. ncbi Nutrient deficiencies in the premature infant
    Malika D Shah
    Department of Pediatrics, Division of Neonatology, Northwestern University s Feinberg School of Medicine, 250 East Superior Street, Suite 05 2146, Chicago, IL 60611, USA
    Pediatr Clin North Am 56:1069-83. 2009
    ..This article reviews the normal accretion of nutrients in the fetus, discusses specific nutrient deficiencies that are exacerbated in the postnatal period, and identifies key areas for future research...
  19. ncbi Nasal CPAP or intubation at birth for very preterm infants
    Colin J Morley
    Neonatal Services, Royal Women s Hospital, Melbourne, Australia
    N Engl J Med 358:700-8. 2008
  20. ncbi Regional brain volume abnormalities and long-term cognitive outcome in preterm infants
    B S Peterson
    Yale Child Study Center, 230 S Frontage Rd, New Haven, CT 06520, USA
    JAMA 284:1939-47. 2000
    ..However, it is not known whether the stresses associated with premature birth disrupt regionally specific brain maturation or whether abnormalities in brain structure contribute to cognitive deficits...
  21. pmc Volumetric analysis of regional cerebral development in preterm children
    Shelli R Kesler
    Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Pediatr Neurol 31:318-25. 2004
    ..Lower birth weight and the presence of intraventricular hemorrhage may increase the risk for neuroanatomic abnormality...
  22. pmc Prenatal predictors of chronic lung disease in very preterm infants
    D J Henderson-Smart
    Centre for Perinatal Health Services Research, University of Sydney, Sydney, Australia
    Arch Dis Child Fetal Neonatal Ed 91:F40-5. 2006
    ..To identify prenatal risk factors for chronic lung disease (CLD) at 36 weeks postmenstrual age in very preterm infants...
  23. ncbi Caudate and hippocampal volumes, intelligence, and motor impairment in 7-year-old children who were born preterm
    Laurence J Abernethy
    Department of Medical Imaging, Royal Liverpool Children s Hospital, Eaton Road, Liverpool L12 2AP, United Kingdom
    Pediatr Res 55:884-93. 2004
    ..These findings suggest abnormal brain development after perinatal injury or postnatal nutritional deficits is responsible for cognitive deficits in preterm children...
  24. ncbi Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort
    E S Draper
    Department of Health Sciences, University of Leicester, 22 28, Princess Road West, Leicester LE1 6TP, UK
    Arch Dis Child Fetal Neonatal Ed 94:F158-63. 2009
    ..To investigate the variation in the survival rate and the mortality rates for very preterm infants across Europe...
  25. pmc Quantitative magnetic resonance imaging of the brain in survivors of very low birth weight
    L J Abernethy
    Department of Child Health, Royal Liverpool Childrens Hospital, Alder Hey, Liverpool, UK
    Arch Dis Child 87:279-83. 2002
    ..Children who survive very low birth weight (VLBW) without major disability have a high prevalence of learning difficulty, attention deficit, and dyspraxia...
  26. pmc Socioeconomic status and perinatal outcomes in a setting with universal access to essential health care services
    K S Joseph
    Perinatal Epidemiology Research Unit, Department of Obstetrics and Gynaecology, Dalhousie University and the IWK Health Centre, Halifax, NS
    CMAJ 177:583-90. 2007
    ..Our objective was to determine whether perinatal and infant outcomes varied by family income and other socioeconomic factors in this setting...
  27. ncbi Reduced lung function in healthy preterm infants in the first months of life
    Luciana Friedrich
    Department of Pediatrics, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Respir Crit Care Med 173:442-7. 2006
    ..Reduced flows have been reported in children and adolescents born prematurely...
  28. ncbi Executive functioning in school-aged children who were born very preterm or with extremely low birth weight in the 1990s
    Peter J Anderson
    Royal Women s Hospital, Melbourne, Australia
    Pediatrics 114:50-7. 2004
  29. ncbi The interrelationship of maternal stress, endocrine factors and inflammation on gestational length
    Roberta J Ruiz
    Department of Family Nursing Care, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229, USA
    Obstet Gynecol Surv 58:415-28. 2003
    ..This review addresses the role of maternal stress on the regulation of maternal hormone and inflammatory responses and how aberrations in these systems may lead to preterm birth...
  30. ncbi Perinatal risk factors altering regional brain structure in the preterm infant
    Deanne K Thompson
    Howard Florey Institute, University of Melbourne, Melbourne, Australia
    Brain 130:667-77. 2007
    ..These findings add to our understanding of the potential pathways leading to altered brain structure and outcome in the preterm infant...
  31. ncbi Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm
    Justine Bacchetta
    Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques, Hopital Femme Mere Enfant, Bron Cedex, France
    Kidney Int 76:445-52. 2009
    ..Extrauterine growth restriction represents a new risk factor for long-term renal impairment in premature children...
  32. ncbi Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants
    Mustafa Anjari
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK
    Neuroimage 35:1021-7. 2007
    ..This study demonstrates that TBSS provides an observer-independent method of identifying white matter abnormalities in the preterm brain at term equivalent age in the absence of focal lesions...
  33. ncbi Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin
    Eloisa Gitto
    Institute of Medical Pediatrics, Neonatal Intensive Care Unit, University of Messina, Italy
    J Pineal Res 36:250-5. 2004
    ..Two of the nonmelatonin-treated newborns died while no children who received melatonin died. Melatonin was well tolerated by the newborns...
  34. ncbi Patterns of motor disability in very preterm children
    Melanie Bracewell
    Academic Division of Child Health, University of Nottingham, United Kingdom
    Ment Retard Dev Disabil Res Rev 8:241-8. 2002
    ..Interventions to prevent cerebral palsy or to reduce these late disabilities in very preterm children are needed...
  35. ncbi Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality
    Serena J Counsell
    Robert Steiner Magnetic Resonance Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
    Pediatrics 112:1-7. 2003
  36. ncbi Very preterm birth is associated with disabilities in multiple developmental domains
    Anneloes L van Baar
    Department of Psychology and Health, Pediatric Psychology, Tilburg University, Tilburg, The Netherlands
    J Pediatr Psychol 30:247-55. 2005
    ..Presence of disabilities in more than one developmental domain will show a more serious outcome picture for extreme preterm infants and may be related to a different degree of perinatal problems...
  37. ncbi Looking back in time: outcome of a national cohort of very preterm infants born in The Netherlands in 1983
    F J Walther
    Department of Pediatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Early Hum Dev 59:175-91. 2000
    ..Abnormalities found during early, standardized clinical neurological examination are highly predictive for these later problems...
  38. ncbi Improved obstetric outcomes and few maternal toxicities are associated with antiretroviral therapy, including highly active antiretroviral therapy during pregnancy
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 38:449-73. 2005
    ..3, 95% CI: 0.2-0.7). Benefits of ART continue to outweigh observed risks...
  39. pmc A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format
    Tanis R Fenton
    Department of Community Health Sciences, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    BMC Pediatr 3:13. 2003
    ..The purpose of this study was to develop an updated growth chart beginning at 22 weeks based on a meta-analysis of published reference studies...
  40. ncbi Oral supplementation with probiotics in very-low-birth-weight preterm infants: a randomized, double-blind, placebo-controlled trial
    Carole Rouge
    INRA UMR 1280, Physiologie des Adaptations Nutritionnelles, INRA and University of Nantes, Human Nutrition Research Center, Nantes, France
    Am J Clin Nutr 89:1828-35. 2009
  41. ncbi Definitions and diagnostic criteria for bronchopulmonary dysplasia
    Eduardo Bancalari
    Division of Newborn Medicine, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
    Semin Perinatol 30:164-70. 2006
    ..In view of all these shortcomings, it is essential to develop more objective physiologic tools to define the degree of lung damage and improve the prediction for long-term outcome in these infants...
  42. ncbi The intestinal bacterial colonisation in preterm infants: a review of the literature
    Elisabeth A M Westerbeek
    Department of Pediatrics, Subdivision of Neonatology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Nutr 25:361-8. 2006
    ..As antibiotics delay the normal intestinal colonisation, caution should be given to the treatment with broadspectrum antibiotics in preterm infants at birth and every attempt has to be made to restrict the period of treatment...
  43. ncbi The impact of preterm birth on hospital inpatient admissions and costs during the first 5 years of life
    Stavros Petrou
    National Perinatal Epidemiology Unit, Institute of Health Sciences, University of Oxford, Oxford, United Kingdom
    Pediatrics 112:1290-7. 2003
    ..To compare the cumulative use and cost of hospital inpatient services to 5 years of age by individuals divided into 4 subgroups by gestational age at birth...
  44. ncbi Outcome at 5 years of age of children 23 to 27 weeks' gestation: refining the prognosis
    L W Doyle
    Department of Obstetrics and Gynaecology, Royal Women s Hospital, Carlton, Australia
    Pediatrics 108:134-41. 2001
    ..To determine the changes with postnatal age for survival, with and without major sensorineural disability, to 5 years of age in very preterm infants and to contrast their prognosis with normal birth weight (NBW) control participants...
  45. pmc Maturation of oral feeding skills in preterm infants
    N Amaizu
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Acta Paediatr 97:61-7. 2008
    ..Safe and successful oral feeding requires proper maturation of sucking, swallowing and respiration. We hypothesized that oral feeding difficulties result from different temporal development of the musculatures implicated in these functions...
  46. ncbi Increased blood pressure but normal renal function in adult women born preterm
    A Kistner
    Institute of Woman s and Child s Health, Karolinska Institute, Astrid Lindgren Children s Hospital Q2 09, 171 77 Stockholm, Sweden
    Pediatr Nephrol 15:215-20. 2000
    ..The objective of this study was to investigate the relationship between birth weight, blood pressure, and kidney function in adult subjects who were born preterm or born small for gestational age (SGA)...
  47. pmc Neurocognitive outcome after very preterm birth
    N Marlow
    Academic Division of Child Health, Queen s Medical Centre, Nottingham, UK
    Arch Dis Child Fetal Neonatal Ed 89:F224-8. 2004
    ..This review looks at outcomes of premature birth at various stages of life with a view to developing and benchmarking perinatal services...
  48. ncbi Depressive symptoms in mothers of prematurely born infants
    Margaret Shandor Miles
    School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7460, USA
    J Dev Behav Pediatr 28:36-44. 2007
    ..The framework for the study was guided by an ecological developmental systems perspective and an adaptation of the Preterm Parental Distress Model...
  49. ncbi Pathology of new bronchopulmonary dysplasia
    Jacqueline J Coalson
    University of Texas Health Science Center, 7703 Floyd Curl Drive, 78229, San Antonio, TX, USA
    Semin Neonatol 8:73-81. 2003
    ..The alveolar and capillary hypoplasia of new BPD will require the development of specific therapies, but avoiding volutrauma, oxidant injury and inflammation/infection will improve lung morphology...
  50. ncbi Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction
    Cristina Borradori Tolsa
    Department of Pediatrics, University Children s Hospital, 1211 Geneva, Swizerland
    Pediatr Res 56:132-8. 2004
    ..These findings may provide insight into the structural-functional correlate for the developmental deficits associated with IUGR...
  51. ncbi Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants
    Linda J Van Marter
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pediatr 140:171-6. 2002
    ..This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection...
  52. ncbi Low species diversity and high interindividual variability in faeces of preterm infants as revealed by sequences of 16S rRNA genes and PCR-temporal temperature gradient gel electrophoresis profiles
    Fabien Magne
    Laboratoire de Biologie, CNAM, Paris, France
    FEMS Microbiol Ecol 57:128-38. 2006
    ..This study will form a comparative framework for other studies, e.g. on the faecal microbiota of preterm infants with different pathologies or the impact of diet on colonization...
  53. ncbi Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants?
    N E Embleton
    Special Care Baby Unit, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Pediatrics 107:270-3. 2001
    ..RDI are based on needs for maintenance and growth, with no provision to replace this deficit. We, therefore, hypothesized that postnatal malnutrition and growth retardation were inevitable in infants fed current RDI...
  54. ncbi Cerebral white matter injury of the premature infant-more common than you think
    Joseph J Volpe
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 112:176-80. 2003
  55. pmc Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Allergy Clin Immunol 121:878-84.e6. 2008
    ..Prematurity (< 37 weeks) has been inconsistently associated with asthma and wheezing. Chorioamnionitis may promote both prematurity and inflammatory pathways in infants' airways...
  56. ncbi Grey and white matter distribution in very preterm adolescents mediates neurodevelopmental outcome
    Chiara Nosarti
    Department of Psychiatry, King s College London Institute of Psychiatry, Denmark Hill, London, UK
    Brain 131:205-17. 2008
    ..Thus, anatomical brain changes may contribute to specific cognitive deficits associated with VPT birth and could be used in the identification of those individuals who may be at increased risk for cognitive impairment...
  57. ncbi A parent-completed developmental questionnaire: follow up of ex-premature infants
    C Y Skellern
    Royal Childrens Hospital and District Health Service, Brisbane, Queensland, Australia
    J Paediatr Child Health 37:125-9. 2001
    ..To explore the test characteristics of an established parent-completed developmental assessment questionnaire 'Ages and Stages Questionnaire' (ASQ) in follow up of an Australian population of premature infants...
  58. ncbi Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection
    Robert C Welliver
    Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children s Hospital of Buffalo, New York 14222, USA
    J Pediatr 143:S112-7. 2003
    ..Pulmonary hypertension and cyanosis are associated with worse outcomes in infants with congenital heart disease, and prolonged viral replication accounts for more severe illness in immunocompromised individuals...
  59. ncbi Impact of a physiologic definition on bronchopulmonary dysplasia rates
    Michele C Walsh
    Rainbow Babies and Childrens Hospital, Department of Pediatrics, CASE Case Western Reserve University, 11100 Euclid Ave, Mailstop 6010, Cleveland, OH 44106, USA
    Pediatrics 114:1305-11. 2004
    ..Safety (apnea, bradycardia, increased oxygen use) and outcomes of the physiologic definition versus the clinical definition were assessed...
  60. ncbi Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants
    Jeffrey I Berman
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 27:862-71. 2005
    ..coil was employed in conjunction with an MR-compatible incubator to perform high-resolution imaging of the premature infant brain...
  61. ncbi Dysfunction of pulmonary surfactant in chronically ventilated premature infants
    Jeffrey D Merrill
    Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
    Pediatr Res 56:918-26. 2004
    ..We conclude that most premature infants requiring continued respiratory support after 7 d of age experience transient episodes of dysfunctional surfactant that are associated with a deficiency of SP-B and SP-C...
  62. ncbi Neighborhood economic disadvantage, violent crime, group density, and pregnancy outcomes in a diverse, urban population
    Christopher M Masi
    University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Soc Sci Med 65:2440-57. 2007
    ..These results suggest that group density and violent crime may impact birth weight via different mechanisms...
  63. ncbi Prematurity, maternal stress and mother-child interactions
    Carole Muller-Nix
    Department of Child and Adolescent Psychiatry, University Hospital Lausanne, Avenue Pierre Decker 5, Lausanne 1011, Switzerland
    Early Hum Dev 79:145-58. 2004
    ..Few studies have explored the relationship between maternal stress and the quality of parent-infant interaction...
  64. ncbi Excess mortality and morbidity among small-for-gestational-age premature infants: a population-based study
    Rivka H Regev
    Neonatal Department Meir Hospital, Kfar Saba, Israel
    J Pediatr 143:186-91. 2003
    ..We examined the effect of intrauterine growth restriction on mortality and morbidity in the Israel cohort of very low birth weight premature infants...
  65. ncbi Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth
    Ann Hellstrom
    Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of the Health of Women and Children, Sweden
    Pediatrics 112:1016-20. 2003
    ..Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that prolonged low IGF-I in premature infants might be a risk factor for ROP...
  66. ncbi Obstetric intervention, stillbirth, and preterm birth
    K S Joseph
    Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
    Semin Perinatol 26:250-9. 2002
    ..Obstetric intervention at preterm gestation, when indicated, can prevent stillbirth and reduce infant morbidity and mortality despite the increasing rates of preterm delivery...
  67. ncbi The effect of averaging time on oximetry values in the premature infant
    Sally Jasmine Maia Ahmed
    Section of Neonatology and Developmental Biology, Departmentof Pediatrics, University of Arizona, Tucson, Arizona 85724, USA
    Pediatrics 125:e115-21. 2010
    ..The effect of a pulse oximeter's averaging time on time spent by premature infants in established saturation ranges, as well as on desaturation events, has not previously been reported...
  68. pmc Randomised trial of early diet in preterm babies and later intelligence quotient
    A Lucas
    Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, London WC1N 1EH, UK
    BMJ 317:1481-7. 1998
    ..To determine whether perinatal nutrition influences cognitive function at 7 1/2 - 8 years in children born preterm...
  69. ncbi Kangaroo Mother Care: 25 years after
    Nathalie Charpak
    Kangaroo Foundation, Bogota, Colombia
    Acta Paediatr 94:514-22. 2005
    ..The psychosocial effects of KMC include reduced stress, enhancement of mother-infant bonding, and positive effects on the family environment and the infant's cognitive development...
  70. ncbi How much sucrose is too much sucrose?
    C Celeste Johnston
    Pediatrics 119:226. 2007
  71. ncbi Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s
    Deanne Wilson-Costello
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Pediatrics 115:997-1003. 2005
  72. ncbi Object working memory deficits predicted by early brain injury and development in the preterm infant
    Lianne J Woodward
    Child Development Research Group, University of Canterbury and Van der Veer Institute for Parkinson s and Brain Research, Christchurch, New Zealand
    Brain 128:2578-87. 2005
    ..These findings add to our understanding of the neuropathological pathways associated with later executive dysfunction in the very preterm infant...
  73. ncbi Correlates of mother-premature infant interactions
    Diane Holditch-Davis
    School of Nursing, Duke University, Durham, NC 27710, USA
    Res Nurs Health 30:333-46. 2007
    ..Greater maternal worry was related to more child irritability. These findings are consistent with the developmental science view that the mother-premature relationship is a complex, reciprocal process...
  74. ncbi Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant
    M Steinbach
    Pediatrix Obstetrix Center for Research and Education and Pediatrix Analytical, Sunrise, FL, USA
    J Perinatol 28:129-35. 2008
    ..The secondary aim of our amino-acid dose comparison trial was to identify factors associated with the development of prolonged cholestatic jaundice...
  75. pmc Socioeconomic inequalities in very preterm birth rates
    L K Smith
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Arch Dis Child Fetal Neonatal Ed 92:F11-4. 2007
    ..To investigate the extent of socioeconomic inequalities in the incidence of very preterm birth over the past decade...
  76. pmc Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review
    W McGuire
    Tayside Institute of Child Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Arch Dis Child Fetal Neonatal Ed 88:F11-4. 2003
    ..To determine if enteral feeding with donor human milk compared with formula milk reduces the incidence of necrotising enterocolitis (NEC) in preterm or low birthweight infants...
  77. ncbi [Brazilian guidelines proposal for screening and treatment of retinopathy of prematurity (ROP)]
    Andrea Zin
    Programa de Saúde da Criança e da Mulher, Instituto Fernandes Figueira, Rio de Janeiro, RJ, Brazil
    Arq Bras Oftalmol 70:875-83. 2007
    ..This document was based on the results of the I Workshop of Retinopathy of Prematurity and presents the attributes for the implementation of an efficient diagnostic and treatment program...
  78. ncbi Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?
    Catherine Limperopoulos
    Department of Neurology and Neurosurgery and School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
    Pediatrics 120:584-93. 2007
    ..We sought to delineate the potential role of cerebellar hemorrhagic injury in the long-term disabilities of survivors of prematurity...
  79. ncbi Delayed childbearing and its impact on population rate changes in lower birth weight, multiple birth, and preterm delivery
    Suzanne C Tough
    Department of Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Pediatrics 109:399-403. 2002
  80. ncbi Reevaluation of the DHA requirement for the premature infant
    Alexandre Lapillonne
    APHP, Paris Descartes University, Paris, France
    Prostaglandins Leukot Essent Fatty Acids 81:143-50. 2009
    ..We estimate that human milk and preterm formula should contain approximately 1.5% of fatty acid as DHA to prevent the appearance of a DHA deficit and to compensate for the early DHA deficit...
  81. ncbi Corpus callosum size and very preterm birth: relationship to neuropsychological outcome
    Chiara Nosarti
    Division of Psychological Medicine, Section of General Psychiatry, PO Box 63, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Brain 127:2080-9. 2004
    ..These results suggest that very preterm birth adversely affects the development of the CC, particularly its posterior quarter, and this impairs verbal skills in boys...
  82. ncbi Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore
    V A Shah
    Department of Neonatology, Singapore General Hospital, Singapore
    Ann Acad Med Singapore 34:169-78. 2005
    ..To determine the incidence, risk factors and need for surgery for retinopathy of prematurity (ROP) among very-low-birth-weight (VLBW) infants...
  83. ncbi Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Acta Paediatr 95:1239-48. 2006
    ..To determine whether gender-specific responses to perinatal and neonatal events and exposures explain the male disadvantage in early childhood outcomes...
  84. ncbi Effects of Bifidobacterium lactis Bb12 supplementation on body weight, fecal pH, acetate, lactate, calprotectin, and IgA in preterm infants
    Ruchika Mohan
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal 14558, Germany
    Pediatr Res 64:418-22. 2008
    ..Fecal calprotectin was lower in the probiotic group (p = 0.041), while fecal IgA was higher in this group compared with the placebo group (p = 0.021)...
  85. ncbi Three-dimensional optical tomography of the premature infant brain
    Jeremy C Hebden
    Department of Medical Physics and Bioengineering, University College London, 11 20 Capper Street, London WC1E 6JA, UK
    Phys Med Biol 47:4155-66. 2002
    ..Results are presented for a premature infant with a cerebral haemorrhage predominantly located within the left ventricle...
  86. ncbi Impaired executive functioning in young adults born very preterm
    Chiara Nosarti
    Division of Psychological Medicine and Psychiatry, Section of General Psychiatry, Institute of Psychiatry and Kings College London, London, United Kingdom
    J Int Neuropsychol Soc 13:571-81. 2007
    ..The results suggest that, although free from major physical disability, VPT young adults perform worse than controls on tasks involving selective aspects of executive processing, such as mental flexibility and response inhibition...
  87. ncbi Crossover trial of analgesic efficacy of glucose and pacifier in very preterm neonates during subcutaneous injections
    Ricardo Carbajal
    Poissy Neonatal Intensive Care Unit, Poissy Saint Germain Hospital, Poissy, France
    Pediatrics 110:389-93. 2002
  88. ncbi Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome
    Beatrice Latal-Hajnal
    Growth and Development Center, University Children s Hospital Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    J Pediatr 143:163-70. 2003
    ..To study the significance of growth status at birth and postnatal growth on neurodevelopmental outcome in very low birth weight (VLBW) infants...
  89. ncbi Declines in low birth weight and preterm birth among infants who were born to HIV-infected women during an era of increased use of maternal antiretroviral drugs: Pediatric Spectrum of HIV Disease, 1989-2004
    Joann Schulte
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Pediatrics 119:e900-6. 2007
    ..Our goal was to determine trends in low birth weight and preterm birth among US infants born to HIV-infected women...
  90. ncbi Rapid cortical oscillations and early motor activity in premature human neonate
    Mathieu Milh
    INMED INSERM U29, Universite de la Mediterranee, Marseille, France
    Cereb Cortex 17:1582-94. 2007
  91. ncbi Neurodevelopmental outcomes of infants born prematurely
    Glen P Aylward
    Division of Developmental and Behavioral Pediatrics, Southern Illinois University School of Medicine, Springfield 62794 9658, USA
    J Dev Behav Pediatr 26:427-40. 2005
    ..Better assessment techniques measuring functions documented to be at higher risk of problems are discussed...
  92. ncbi Increased risk of bronchopulmonary dysplasia and increased mortality in very preterm infants being small for gestational age
    Irwin Reiss
    Pediatric Center, Department of Pediatrics and Neonatology, Justus Liebig University, Feulgenstrasse 12, 35385 Giessen, Germany
    Arch Gynecol Obstet 269:40-4. 2003
    ..The objective was to evaluate the impact of being born small for gestational age (SGA) on neonatal mortality and neonatal pulmonary morbidity in preterm infants <32 weeks of gestation...
  93. ncbi Gestational age and birth weight in relation to school performance of 10-year-old children: a follow-up study of children born after 32 completed weeks
    Ida Kirkegaard
    Department of Obstetrics, Aarhus University Hospital, Skejby Sygehus, 8200 Aarhus N, Denmark
    Pediatrics 118:1600-6. 2006
    ..Much less is known about children of higher gestational ages and birth weights. We studied gestational age after 32 completed weeks and birth weight in relation to the child's school performance at the age of 10 years...
  94. ncbi Hydrolysed protein accelerates the gastrointestinal transport of formula in preterm infants
    W A Mihatsch
    Department of Pediatrics, University of Ulm, Germany
    Acta Paediatr 90:196-8. 2001
    ..Conclusion: The hydrolysate protein formula accelerated gastrointestinal transit of milk and stools, but whether hydrolysate formulas enable a more rapid establishment of full enteral feeding in preterm infants needs to be investigated...
  95. ncbi Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC)
    Catherine J Hunter
    Department of Surgery, University of Southern California, Keck School of Medicine, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    Pediatr Res 63:117-23. 2008
    ..Finally, we comment on the possible role for probiotics in promoting maturation of intestinal defense mechanisms thereby attenuating or preventing the sequence of events that lead to NEC...
  96. ncbi Cerebellar injury in preterm infants: incidence and findings on US and MR images
    Sylke J Steggerda
    Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Albinusdreef 2, J6 S, 2333 ZA Leiden, The Netherlands
    Radiology 252:190-9. 2009
  97. ncbi Polymorphism of tumor necrosis factor-alpha and risk and severity of bronchopulmonary dysplasia among very low birth weight infants
    S Nadya J Kazzi
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Hutzel Women s Hospital, 4707 St Antoine, Detroit, Michigan 48201, USA
    Pediatrics 114:e243-8. 2004
    ..High levels of TNF-alpha may promote chronic inflammation by overwhelming counter-regulatory mechanisms and may lead to the development of BPD. Low levels of TNF-alpha may decrease the risk and/or severity of BPD...
  98. pmc Synthetic orocutaneous stimulation entrains preterm infants with feeding difficulties to suck
    S M Barlow
    Department of Speech Language Hearing Sciences and Disorders, University of Kansas, Lawrence, KS 66045, USA
    J Perinatol 28:541-8. 2008
    ..The extent to which suck can be entrained using a synthetically patterned orocutaneous input to promote its development in preterm infants who lack a functional suck is unknown...
  99. pmc Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants
    G Boehm
    Numico Research Germany, Friedrichsdorf, Germany
    Arch Dis Child Fetal Neonatal Ed 86:F178-81. 2002
    ..The establishment of a balanced intestinal microflora which may protect against infection is desirable for the preterm infant...
  100. ncbi Early alterations of growth factor patterns in bronchoalveolar lavage fluid from preterm infants developing bronchopulmonary dysplasia
    Jasper V Been
    Department of Paediatrics, Maastricht University Medical Centre, Maastricht 6202 AZ, The Netherlands
    Pediatr Res 67:83-9. 2010
    ..01). In conclusion, substantial alterations in BALF growth factor levels are present in infants developing BPD. An early imbalance in pulmonary growth factors may contribute to the developmental arrest of the lung seen in BPD...
  101. ncbi Case-control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33-35 weeks in Spain
    Jose Figueras-Aloy
    Hospital Clinic, Unitat Integrada Pediatría, Institut d Investigacions Biomediques August Pi i Sunyer, 0828 Barcelona, Spain
    Pediatr Infect Dis J 23:815-20. 2004
    ..The aim of this study was to identify those risk factors most likely to lead to the development of RSV-related respiratory Infection and subsequent hospital admission among premature infants born at 33-35 WGA (FLIP study)..

Research Grants72

  1. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..Marketing approval for TLF to treat NIs would be of great benefit to the patients and the community, and would also be of a substantial commercial value. ..
  2. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
  3. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..SGS is preventable and is caused by endotracheal intubation during the critical first days of life. In the premature infant and newborn, this condition may pass undetected or present as a life-threatening event...
  4. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..The heart will undergo morphometric analysis for evidence of PAH (as shown by right ventricular (RV) hypertrophy). ..
  5. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..provided by applicant): Respiratory Distress Syndrome (RDS) is a life-threatening condition of the premature infant, wherein the lung is developmentally unprepared for ex utero function and rapidly develops edema, poor ..
  6. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..g., dihydroethidium);and NADPH oxidase activation. ..
  7. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    ..g., dihydroethidium);and NADPH oxidase activation. ..
  8. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..The data generated from the proposed studies will directly lead to decisions concerning future randomized safety and efficacy trials of LGG to prevent NEC in the preterm population. ..
  9. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
  10. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
  11. DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
    LYNETTE KAY ROGERS; Fiscal Year: 2013
  12. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..Pain will be quantified using a validated pain scoring tool, the Premature Infant Pain Profile (PIPP)...
  13. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..Reducing the preterm birth rate to 7% in the United States is a goal of the Healthy People 2010 initiative, and it is only by reducing the incidence of preterm birth that infant mortality in the United States can be addressed. ..
  14. Foxf1 Transcription Factor in Development of Pulmonary Capillaries
    Vladimir V Kalinichenko; Fiscal Year: 2013
  15. Downregulation of Rod Metabolism in Retinopathy of Prematurity
    JAMES DANIEL AKULA; Fiscal Year: 2010
    ..Thus, suppression of metabolically demanding processes in the rods promises preservation of visual function and prevention of vascular disease. ..
  16. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    ..We have a unique and important opportunity to investigate the consequences of BPD on lung and right heart function in this population, which will inform treatment strategies and predictions of disease progression in the future. ..
  17. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
  18. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..abstract_text> ..
  19. Research Career Development in Child Health
    Michael W Konstan; Fiscal Year: 2012
    ..abstract_text> ..
  20. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
  21. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
  22. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2013
    ..abstract_text> ..
  23. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..A better understanding of how angiogenesis is regulated will aid in development of new and more effective therapies for these blinding diseases, as well as other diseases with a neovascular component. ..
  24. Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
    Sarosh Rana; Fiscal Year: 2013
    ..The combined expertise of mentors and collaborators provide a unique opportunity for the applicant to achieve the goals of this project and to start a career as an independent investigator. ..
  25. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..Therefore, we propose to conduct a randomized, double-blind, controlled, vaccine trial in Guatemala to evaluate the efficacy of influenza immunization in pregnancy for protecting mothers and their infants. ..
  26. A Cohort Study of Preterm Delivery in Relation to Partner Abuse, Mood and Anxiety
    Michelle A Williams; Fiscal Year: 2013
    ..S. Congress'passing of the Prematurity Research Expansion and Education for Mothers who Deliver Infants Early (PREEMIE) Act (P.L. 109-450)234. ..
  27. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - Clinical Coordinatin
    Ronald Wapner; Fiscal Year: 2012
    ..However the very premature infant accounts for a relatively small portion of preterm birth...
  28. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..This proposal will provide new insights into the molecular mechanisms of CCN1 activities in vivo and may foster future safer, less destructive, and more effective therapies to harness ischemia-induced neovascularization in ROP. ..
    Jack L Feldman; Fiscal Year: 2012
    ..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
    Ronald M Evans; Fiscal Year: 2013
  31. Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies
    RITA MARIE RYAN; Fiscal Year: 2013
    ..The future of many vulnerable children depends on this pioneering approach to the Prematurity and Respiratory Outcomes Program, PROP. ..
  32. Modulation of TLR4 and TLR9 Signaling in NEC
    David J Hackam; Fiscal Year: 2013
    ..unrecognized effects on the induction of endoplasmic reticulum (ER) stress in the intestinal mucosa of the premature infant. ER stress reflects a cellular state of accumulated mis-folded proteins within the lumen of the ER, which ..
  33. Placental shape features, gestational timing and maternal and infant health
    Carolyn M Salafia; Fiscal Year: 2011
    Paul Gray; Fiscal Year: 2013
    ..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..
  35. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..Finally, any study involving the premature infant and the data associated with it must be viewed in light of the critical relationship between the mother and ..
  36. Probiotics and Innate Intestinal Defense
    ..period elicits an exaggerated inflammatory response by the "immature" intestinal epithelial cells of the premature infant. Furthermore, recently, aberrant or excessive apoptosis of the gut epithelia has been recognized as either an ..
  37. Maturation of intestinal innate immunity and NEC
    W Allan Walker; Fiscal Year: 2013
    ..The hypothesis is that colonization of the premature infant gut prior to maturation of the TLR signaling pathway can lead to excessive inflammation of the infant gut ..
  38. XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung Disease
    SEAN BEDILION FAIN; Fiscal Year: 2013
    ..To apply ventilation/perfusion MRI to clinical research investigations of early disease in asthma, CF, and BPD, while supporting ongoing studies of adult lung disease and expansion to new opportunities. ..
  39. Cooperative Multicenter Maternal Fetal Medicine Units Networks
    John M Thorp; Fiscal Year: 2013
    ..This is particularly important in North Carolina as the state ranks in the bottom third of the nation with regard to perinatal/maternal health and infant mortality. ..
  40. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
  41. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2013
  42. Sensorimotor Control of the Human Orofacial System
    Steven M Barlow; Fiscal Year: 2012
  43. Assessment of lung function in neonates and infants
    IULIAN CONSTANTIN RUSET; Fiscal Year: 2013
    ..One subject will be a neonate born prematurely who has early BPD. The second subject will be a neonate under care due to an hypoxic ischemic event. This subject's lungs should be structurally normal. ..
  44. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    ..Here, the natural structural and biochemical cues provided by native interphotoreceptor matrix (IPM) will be used to promote RPC survival and integration into adjacent host retina. ..
  45. International Epidemiologic Databases to Evaluate AIDS-Southern Africa (IeDEA-SA)
    Matthias Egger; Fiscal Year: 2013
    ..Operational, clinical and public health research is urgently needed to guide the long-term delivery of HIV care and ART to the many patients in need, including pregnant women, infants, children and adolescents. ..
  46. The control of retinal vascular development by Norrin and Frizzled4
    Jeremy Nathans; Fiscal Year: 2013
    ..1 ..
  47. Cytokines and the blood-brain barrier in the ovine fetus
    Barbara S Stonestreet; Fiscal Year: 2012
    ..This project may provide new insights into novel strategies to prevent brain injury in the human fetus and/or premature infant. Perinatal hypoxic/ischemic brain injury often results in cerebral palsy (CP) and mental retardation...
  48. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2009
  49. NICHD Cooperative Multicenter Neonatal Research Network
    Abbot R Laptook; Fiscal Year: 2013
    ..Serious neonatal problems may also afflict infants born at term. This application uses a multi- center network to perform rigorous clinical research to improve the outcome of preterm and term infants. ..
    Carole R Mendelson; Fiscal Year: 2013
    ..We propose that these interrelated projects, carried out by a highly interactive research team, will achieve the long-range goals of this Program and contribute to a reduction in the incidence of preterm birth. ..
  51. Ophthalmologic Follow-up Care for Children Born Very-Low-Birth-Weight
    CHIHHUNG JASON WANG; Fiscal Year: 2012
    ..The findings will have important public health implications for tracking their health, development, and educational outcomes. ..
  52. Artificial Placenta Device
    KATHRYN R OSTERHOLZER; Fiscal Year: 2013
    ..This project has high translational potential and would impact substantially upon the care of high risk premature newborns. Successful completion of this research will lead to a clinical trial in moribund premature infants. ..
  53. The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity
    John P Cooke; Fiscal Year: 2013
    ..abstract_text> ..
  54. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Such an approach will provide a rational basis for the development of potentially powerful and effective therapeutics for ocular neovascularization. ..
  55. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
  56. Thiamine Deficiency and Acquired Auditory Neuropathy
    M Charles Liberman; Fiscal Year: 2013
  57. Long-term effects of caffeine therapy for apnea of prematurity on sleep disorders
    Carole L Marcus; Fiscal Year: 2012
    ..These studies will help determine the long-term consequences of neonatal methylxanthine therapy, ultimately resulting in improved management of apnea of prematurity. ..
  58. Atlas - A Handheld High Resolution Wide-field Retinal Imager
    PAUL ANDREW YATES; Fiscal Year: 2013
    ..abstract_text> ..
  59. Generation of Respiratory Rhythm
    Jack L Feldman; Fiscal Year: 2013
  60. Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary Dysplasia
    Aaron Hamvas; Fiscal Year: 2013
    ..Identifying the role that these bacteria play will permit early treatment in an effort to prevent the development of these lung problems. (End of Abstract) ..
  61. Functional dissection of medullary respiratory microcircuits
    Jack L Feldman; Fiscal Year: 2013
    ..Analysis of such perturbations will provide an extraordinary window into understanding mechanisms of respiratory rhythm and pattern generation. ..
    Gail Cassell; Fiscal Year: 1991
    ..Particular attention will be given to the duration of labor prior to culture...
  63. Multiple Chronic Conditions in VLBW Infants: Epidemiology, NICU Care, and Outcome
    William Gardner; Fiscal Year: 2010
    ..Because PVLBW babies are often subject to multiple chronic disorders and are over-represented in an underserved community, they are a priority population for comparative effectiveness research. ..
    PETER MCGOVERN; Fiscal Year: 2004
    ..We will then test the hypothesis that this novel protocol, by preventing the hypersecretion of luteal products in gonadotropin-induced pregnancies, will result in safer infertility therapy. ..
    Michael Gravett; Fiscal Year: 2005
    ..These studies will clarify the pathophysiology of infection-associated preterm labor and will suggest effective interventional strategies. ..
  66. A Model Statewide Trial to Detect and Treat Maternal Hypothyroidism in Pregnancy
    James Haddow; Fiscal Year: 2009
    ..This approach can eventually be implemented throughout the United States. ..
  67. Induction of the blood-retinal barrier
    DAVID ANTONETTI; Fiscal Year: 2010
    ..Understanding this mechanism will lead to new therapies to restore the blood-retinal barrier in retinal vascular diseases, with limited side effects. ..
  68. A Novel Model to Study Retinopathy of Prematurity
    David Moscatelli; Fiscal Year: 2003
    ..Our model will provide a useful tool to directly examine the roles of various factors in retinal vascular diseases in a setting that maintains normal tissue architecture. ..
    MARY REUSS; Fiscal Year: 1993
  70. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2005
    ..If this study confirms the benefits seen in the pilot study, it will result in a significant improvement in health care for premature infants, both by introducing a beneficial new therapy, and by avoiding higher dose dexamethasone. ..
  71. Neonatal apnea: Online risk score from new analyses of bedside monitor waveforms
    JOSEPH RANDALL contact MOORMAN; Fiscal Year: 2010