carotid arteries

Summary

Summary: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.

Top Publications

  1. ncbi Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis
    Matthias W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Circulation 115:459-67. 2007
  2. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
  3. ncbi Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    D H O'Leary
    Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
    N Engl J Med 340:14-22. 1999
  4. pmc Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA
    Stroke 41:9-15. 2010
  5. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
  6. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:139-46. 2003
  7. doi Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease
    Michael H Davidson
    Radiant Research and University of Chicago, Chicago, IL, USA
    Am J Cardiol 104:936-42. 2009
  8. pmc Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes
    Qin Li
    Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China
    Cardiovasc Diabetol 10:72. 2011
  9. ncbi Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
  10. ncbi Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
    J H von der Thüsen
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, Leiden, The Netherlands
    Circulation 103:1164-70. 2001

Research Grants

  1. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
  2. Ralph L Sacco; Fiscal Year: 2014
  3. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    Akira Sekikawa; Fiscal Year: 2012
  4. Raj Kishore; Fiscal Year: 2014
  5. Role of miR-145 in Vascular Smooth Muscle Cell BiologyRole of
    Chunxiang Zhang; Fiscal Year: 2013
  6. Genetic Predisposition for Intimal Hyperplasia in Mice
    Renee C LeBoeuf; Fiscal Year: 2013
  7. Cellular and molecular mechanisms of preterm white matter injury
    Art Riddle; Fiscal Year: 2013
  8. Role of Ribosomal Proteins in Vascular Smooth Muscle Cell Proliferation
    Elaine M Smolock; Fiscal Year: 2010
  9. Sharon Francis; Fiscal Year: 2014
  10. PATRICK ANDRIES MURPHY; Fiscal Year: 2014

Detail Information

Publications363 found, 100 shown here

  1. ncbi Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis
    Matthias W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Circulation 115:459-67. 2007
    ..Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association...
  2. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
    ..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
  3. ncbi Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    D H O'Leary
    Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
    N Engl J Med 340:14-22. 1999
    ..We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease...
  4. pmc Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA
    Stroke 41:9-15. 2010
    ....
  5. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  6. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:139-46. 2003
  7. doi Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease
    Michael H Davidson
    Radiant Research and University of Chicago, Chicago, IL, USA
    Am J Cardiol 104:936-42. 2009
    ....
  8. pmc Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes
    Qin Li
    Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China
    Cardiovasc Diabetol 10:72. 2011
    ..We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes...
  9. ncbi Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
    ....
  10. ncbi Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
    J H von der Thüsen
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, Leiden, The Netherlands
    Circulation 103:1164-70. 2001
    ..In mice, however, atherosclerosis-like lesions have thus far not been obtained by this method. The aim of this study was the development of a mouse model of rapid, site-controlled atherogenesis...
  11. ncbi Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 107:2089-95. 2003
    ..In nondiabetic individuals, increased arterial stiffness is an important cause of cardiovascular disease. Associations between DM-2 and IGM and arterial stiffness have not been systematically investigated...
  12. pmc Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice
    Yanhua Hu
    Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, London, United Kingdom
    J Clin Invest 113:1258-65. 2004
    ..Our findings indicate that ex vivo expansion of these progenitor cells may have implications for cellular, genetic, and tissue engineering approaches to vascular disease...
  13. doi Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey
    Teemu Koivistoinen
    Department of Clinical Physiology, University of Tampere and Tampere University Hospital, FI 33521, Tampere, Finland
    Atherosclerosis 220:387-93. 2012
    ....
  14. ncbi Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury
    Aesim Cho
    Department of Pathology, University of Washington, Seattle 98026, USA
    Circ Res 91:845-51. 2002
    ..Thus, our present data indicate that MMP-9 is critical for the development of arterial lesions by regulating both SMC migration and proliferation...
  15. ncbi Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study
    Angel Brea
    Lipid Clinic, Internal Medicine Service, Hospital San Millán San Pedro, Logrono, Spain
    Arterioscler Thromb Vasc Biol 25:1045-50. 2005
    Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. We examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries.
  16. pmc Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy
    Allison C Ross
    Rainbow Babies and Children s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Clin Infect Dis 49:1119-27. 2009
    ....
  17. pmc Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study
    Joseph F Polak
    Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Diabetes 60:607-13. 2011
    ..This study investigated the long-term effects of intensive diabetic treatment on the progression of atherosclerosis, measured as common carotid artery intima-media thickness (IMT)...
  18. ncbi Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, WA, USA
    Stroke 37:818-23. 2006
    ..We tested the hypothesis that the characteristics of carotid plaque, as assessed by MRI, are possible predictors of future ipsilateral cerebrovascular events...
  19. ncbi Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006
    P J Touboul
    Cerebrovasc Dis 23:75-80. 2007
    ..This will help to improve the power of randomized clinical trials incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses...
  20. ncbi Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses
    Priscilla Y Hsue
    Divisions of Cardiology, San Francisco General Hospital, University of California, San Francisco, USA
    AIDS 20:2275-83. 2006
    ....
  21. ncbi Cellular and morphological changes during neointimal hyperplasia development in a porcine arteriovenous graft model
    Li Li
    Department of Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Nephrol Dial Transplant 22:3139-46. 2007
    ..The nature of the proliferating cells in these lesions is not well understood. A better understanding of the cells contributing to NH is important to the development of preventive strategies...
  22. doi Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity
    Stefano Coli
    Department of Cardiothoracic and Vascular Diseases, University Vita Salute, San Raffaele Scientific Institute, Milan, Italy
    J Am Coll Cardiol 52:223-30. 2008
    ..This study was designed to evaluate contrast-enhanced ultrasound imaging of carotid atherosclerosis as a clinical tool to study intraplaque neovascularization...
  23. doi Sixty-four-section multidetector CT angiography of carotid arteries: a systematic analysis of image quality and artifacts
    J J Kim
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, California 94143 0628, USA
    AJNR Am J Neuroradiol 31:91-9. 2010
    ..The goals of this study were to systematically measure image quality and determine the prevalence of various types of artifacts produced by a 64-section scanner...
  24. pmc Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency
    Sanjay Misra
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Alfred 6460, Rochester, MN 55905, USA
    J Vasc Interv Radiol 21:1255-61. 2010
    ....
  25. pmc Markers of atherosclerosis and inflammation and mortality in patients with HIV infection
    Alexandra Mangili
    Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Atherosclerosis 214:468-73. 2011
    ..We examined the association of all-cause mortality in HIV-infected patients with carotid artery intima-media thickness (cIMT) and high-sensitivity C-reactive protein (hsCRP)...
  26. pmc T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    J Infect Dis 203:452-63. 2011
    ..It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults...
  27. doi Computed tomography angiography of the carotid arteries at low kV settings: a prospective randomised trial assessing radiation dose and diagnostic confidence
    Dietrich Beitzke
    Division of Cardiovascular and Interventional Radiology, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur Radiol 21:2434-44. 2011
    ..To assess radiation dose and diagnostic image quality of a low-dose (80 kV) versus a standard-dose (120 kV) protocol for computed tomography angiography (CTA) of the supra-aortic arteries...
  28. doi Arterial stiffness is associated with minimally elevated high-sensitivity cardiac, troponin T levels in a community-dwelling population
    Yongyi Bai
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Atherosclerosis 218:493-8. 2011
    ..The current study investigated the relationship between plasma hsTnT levels and alterations in arterial stiffness in a community-based population...
  29. pmc Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling
    Mehmet H Kural
    Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, United States
    J Biomech 45:790-8. 2012
    ..The goal of this study is to characterize the behavior of diseased human coronary and carotid arteries using planar biaxial testing...
  30. ncbi Naringenin inhibits angiotensin II-induced vascular smooth muscle cells proliferation and migration and decreases neointimal hyperplasia in balloon injured rat carotid arteries through suppressing oxidative stress
    Changwu Xu
    Department of Cardiology, Renmin Hospital of Wuhan University Cardiovascular Research Institute of Wuhan University
    Biol Pharm Bull 36:1549-55. 2013
    ..II-induced VSMCs proliferation and migration and decrease neointimal hyperplasia in balloon injured rat carotid arteries. VSMCs were treated with or without naringenin before stimulation with 1 µM angiotensin II and twenty-four ..
  31. doi Dietary intervention to reverse carotid atherosclerosis
    Iris Shai
    Department of Epidemiology and Health Systems Evaluation, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Circulation 121:1200-8. 2010
    ..It is currently unknown whether dietary weight loss interventions can induce regression of carotid atherosclerosis...
  32. ncbi Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall
    Sebastian Albinsson
    Vascular Physiology Group, Department of Experimental Medical Science, Lund University, BMC D12, Lund SE 221 84, Sweden
    Am J Physiol Cell Physiol 294:C271-9. 2008
    ..KO carotid arteries had increased wall cross sections and responded to pressurization (120 mmHg) for 1 h with increased ERK1/2 ..
  33. doi The association between carotid or femoral atherosclerosis and low bone mass in postmenopausal women referred for osteoporosis screening. Does osteoprotegerin play a role?
    P Pennisi
    Department of Internal Medicine, University of Catania, Catania, Italy
    Maturitas 67:358-62. 2010
    ..057; p=0.042). The association between OPG and the number of plaques was significant only in patients with concomitant involvement of carotid and femoral districts (r(2)=0.758; p<0.0001)...
  34. doi Study of carotid arterial plaque stress for symptomatic and asymptomatic patients
    Hao Gao
    Centre for excellence in Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow G11XW, UK
    J Biomech 44:2551-7. 2011
    ..The combined analyses of plaque MR image and plaque stress will advance our understanding of plaque rupture, and provide a useful tool on assessing plaque rupture risk...
  35. ncbi Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia
    Masafumi Kuzuya
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Toyonaka, Nagoya 466 8550, Japan
    Circulation 108:1375-81. 2003
    ..To define the role of MMP-2 in arterial remodeling, we evaluated the influence of the targeted deletion of the MMP-2 gene on vascular remodeling after flow cessation in the murine carotid arteries.
  36. ncbi Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology and PET Centre, University of Turku, Turku
    JAMA 290:2277-83. 2003
    ..Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life...
  37. ncbi Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries
    Tongrong He
    Mayo Clinic of Medicine, Rochester, Minn 55905, USA
    Stroke 35:2378-84. 2004
    ..The present study was designed to determine the effect of EPCs transplantation on the regeneration of endothelium and recovery of endothelial function in denuded carotid arteries.
  38. ncbi The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study
    Isabel Ferreira
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Arch Intern Med 165:875-82. 2005
    ..We therefore examined whether the metabolic syndrome was associated with arterial stiffness and whether any such associations were independent of cardiopulmonary fitness and subcutaneous trunk fat...
  39. ncbi Global vasomotor dysfunction and accelerated vascular aging in beta-thalassemia major
    George Hahalis
    Department of Cardiology, University Hospital of Patras, Greece
    Atherosclerosis 198:448-57. 2008
    ..We investigated the arterial vasorelaxing capacity and sought for early carotid atherosclerosis and underlying pathophysiological correlates in these transfusion-dependent patients...
  40. doi Segmentation in ultrasonic B-mode images of healthy carotid arteries using mixtures of Nakagami distributions and stochastic optimization
    Francois Destrempes
    Laboratoire de Biorhéologie et d Ultrasonographie Médicale LBUM, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, QC, H2L 2W5 Canada
    IEEE Trans Med Imaging 28:215-29. 2009
    The goal of this work is to perform a segmentation of the intimamedia thickness (IMT) of carotid arteries in view of computing various dynamical properties of that tissue, such as the elasticity distribution (elastogram)...
  41. doi An echolucent carotid artery intima-media complex is a new and independent predictor of mortality in an elderly male cohort
    M Wohlin
    Department of Public Health and Caring Sciences, Uppsala University, Sweden
    Atherosclerosis 205:486-91. 2009
    ..We investigated the prognostic value of intima-media (IM) echogenicity (measured as the grey scale median [GSM]) for mortality compared with intima-media thickness (IMT) in a population-based sample of elderly men...
  42. doi Atherosclerotic plaque disruption induced by stress and lipopolysaccharide in apolipoprotein E knockout mice
    Mei Ni
    Shandong Univ Qilu Hospital, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, P R China
    Am J Physiol Heart Circ Physiol 296:H1598-606. 2009
    ..Plasma fibrinogen levels were remarkably elevated in the stress and stress+LPS groups. In conclusion, stress- and LPS-costimulated apoE(-/-) mice provide a useful model for studies of plaque vulnerability and interventions...
  43. doi Extended-release niacin or ezetimibe and carotid intima-media thickness
    Allen J Taylor
    Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
    N Engl J Med 361:2113-22. 2009
    ....
  44. pmc Impaired endothelial function in preadolescent children with type 1 diabetes
    Ghufran S Babar
    Department of Pediatric Endocrinology, Children s Mercy Hospital, Kansas City, Missouri, USA
    Diabetes Care 34:681-5. 2011
    ....
  45. doi Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population
    Minghua Zhang
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Clin Cardiol 34:622-7. 2011
    ..Moreover, the association between pulse wave velocity (PWV) and augmentation index (AIx) in diabetes is poorly understood...
  46. doi Early adverse effect of abnormal glucose metabolism on arterial stiffness in drug naive hypertensive patients
    Gregory Vyssoulis
    Hypertension and Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
    Diab Vasc Dis Res 9:18-24. 2012
    ..Given the prognostic significance of arterial stiffness, aims should be towards closer monitoring and intensive care of hypertensive patients with abnormal glucose metabolism...
  47. pmc Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Norwood, MA 02062, USA
    Brain 134:3398-407. 2011
    ..We hypothesized that disproportionate stiffening of the proximal aorta as compared with the carotid arteries reduces wave reflection at this important interface and thereby facilitates transmission of excessive ..
  48. ncbi Altered expression balance of matrix metalloproteinases and their inhibitors in human carotid plaque disruption: results of quantitative tissue analysis using real-time RT-PCR method
    Takeo Higashikata
    Division of Cardiovascular Medicine and Bioscience, National Cardiovascular Center and Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 185:165-72. 2006
    ....
  49. pmc Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Circulation 111:576-82. 2005
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis...
  50. ncbi Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromsø Study
    Stein Harald Johnsen
    Department of Neurology, University Hospital North Norway, N 9038 Tromsø, Norway
    Stroke 38:2873-80. 2007
    Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease...
  51. pmc Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women
    Christina M Parrinello
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 205:1788-96. 2012
    ..We hypothesized that CMV is associated with vascular disease in HIV-infected adults...
  52. pmc Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage
    Zhongzhao Teng
    University Department of Radiology, University of Cambridge, UK
    Atherosclerosis 223:321-6. 2012
    ..Local mechanical environments around neovessels and their relevant pathophysiologic significance have not yet been examined...
  53. ncbi Functional profile of activated dendritic cells in unstable atherosclerotic plaque
    Christian Erbel
    Department of Cardiology, Internal Medical Clinic III University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 102:123-32. 2007
    ..This study established a functional profile of plaque-residing dendritic cells (DC) to examine whether they can function as Ag-presenting cells to facilitate in situ T-cell activation...
  54. pmc Noninvasive assessment of preclinical atherosclerosis
    Helen A Lane
    Department of Endocrinology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Vasc Health Risk Manag 2:19-30. 2006
    ..This review outlines the various modalities, indications, and limitations of available methods to assess arterial dysfunction and vascular risk...
  55. ncbi VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries
    S Bhardwaj
    University of Kuopio, Kuopio, Finland
    Eur J Clin Invest 35:669-76. 2005
    ..This investigation conducted a comparative study with adenoviruses encoding different VEGFs in a rabbit carotid artery collar model of intimal hyperplasia in order to analyze the role of VEGFs in the formation of intimal hyperplasia...
  56. ncbi Both long-term HIV infection and highly active antiretroviral therapy are independent risk factors for early carotid atherosclerosis
    M W Lorenz
    Johann Wolfgang Goethe University Hospital, Department of Neurology, Frankfurt am Main, Germany
    Atherosclerosis 196:720-6. 2008
    ..We investigated the relationship between HIV infection, antiretroviral medication and ultrasound evidence of early atherosclerosis in the context of vascular risk factors...
  57. doi Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement
    Thomas Weber
    Cardiology Department, Klinikum Wels Grieskirchen, Grieskirchnerstrasse 42, Wels 4600, Austria
    J Hypertens 27:1624-30. 2009
    ..The aim of our study was to compare cfPWV, calculated with commonly used noninvasive methods for travel distance assessment, against aortic PWV measured invasively...
  58. ncbi RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium
    P von Hundelshausen
    , , Munich, Germany
    Circulation 103:1772-7. 2001
    ..Immunohistochemistry revealed that RANTES is present on the luminal surface of carotid arteries of apolipoprotein E-deficient mice with early atherosclerotic lesions after wire-induced injury or cytokine ..
  59. ncbi Increased intima-media thickness of the carotid artery wall, normal blood pressure profile and normal left ventricular mass in subjects with primary hyperparathyroidism
    V Nuzzo
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Eur J Endocrinol 147:453-9. 2002
    ..Given the multiple influence of PHPT on the cardiovascular system, this study aimed to assess the effects of PHPT on blood pressure profile, and on features of the heart and arterial vessels in normotensive symptomless patients...
  60. ncbi In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI
    Rikin A Trivedi
    University Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Stroke 35:1631-5. 2004
    ..The purpose of this study was to determine the time course for macrophage visualization with in vivo contrast-enhanced MRI using an ultrasmall superparamagnetic iron oxide (USPIO) agent in symptomatic human carotid disease...
  61. ncbi High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Divisions of Rheumatology and Cardiology, Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 32:1219-23. 2005
    ..We examined the relationship between carotid IMT to C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are the most commonly assessed markers of inflammatory response in patients with RA...
  62. doi Age-associated elongation of the ascending aorta in adults
    Jun Sugawara
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712 1204, USA
    JACC Cardiovasc Imaging 1:739-48. 2008
    ..To determine whether human aorta lengthens with aging and to evaluate the impact of the hypothesized aortic elongation on pulse wave velocity (PWV) measurements...
  63. doi Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Department of Medicine, University of Turku and Turku University Central Hospital, PO Box 52, 20500 Turku, Finland
    Eur Heart J 31:1745-51. 2010
    ..The aim of this study is to evaluate whether childhood risk factors are associated with a 6-year change in carotid intima-media thickness (IMT) in young adulthood independent of the current risk factors...
  64. ncbi Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial
    Rainer Rauramaa
    Kuopio Research Institute of Exercise Medicine, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
    Ann Intern Med 140:1007-14. 2004
    ..Although regular physical activity is recommended for prevention of cardiovascular diseases, no data are available on its antiatherosclerotic effects in the general population...
  65. doi Periodontitis and risk for atherosclerosis: an update on intervention trials
    Maurizio S Tonetti
    European Research Group on Periodontology ERGOPERIO, Berne, Switzerland
    J Clin Periodontol 36:15-9. 2009
    ..Intervention trials are critical to explore the relationship. If the association were causal, successful periodontal therapy will lead to an attenuation of the effect - CVD...
  66. ncbi Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
    G Howard
    Department of Public Health Sciences of Wake Forest University, Winston Salem, NC 27157 1063, USA
    JAMA 279:119-24. 1998
    ..Cigarette smoking is a powerful risk factor for incident heart disease and stroke, but the relationship of active and passive smoking with the progression of atherosclerosis has not been described...
  67. ncbi Absence of CD40 signaling is associated with an increase in intimal thickening after arterial injury
    M Remskar
    Division of Cardiology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, California, USA
    Circ Res 88:390-4. 2001
    ..These data suggest that CD40 signaling plays a significant role in the inhibitory effect of T lymphocytes on intimal thickening after arterial injury...
  68. ncbi Ultrasonic echolucent carotid plaques predict future strokes
    M L Grønholdt
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 104:68-73. 2001
    ..We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients...
  69. ncbi Central blood pressure measurements and antihypertensive therapy: a consensus document
    Enrico Agabiti-Rosei
    Clinica Medica and Department of Medicine, University Hospital, Brescia, Italy
    Hypertension 50:154-60. 2007
  70. pmc Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
    C M Giachelli
    Department of Pathology SJ 60 University of Washington School of Medicine, Seattle 98195
    J Clin Invest 92:1686-96. 1993
    ..These data implicate osteopontin as a potentially important mediator of arterial neointima formation as well as dystrophic calcification that often accompanies this process...
  71. ncbi Production of the long pentraxin PTX3 in advanced atherosclerotic plaques
    Michael S Rolph
    Heart Research Institute, Camperdown, New South Wales, Australia
    Arterioscler Thromb Vasc Biol 22:e10-4. 2002
    ..Infrequent expression by smooth muscle cells was also observed. Our results suggest that PTX3 may contribute to the pathogenesis of atherosclerosis...
  72. ncbi Arterial stiffness and cardiovascular risk factors in a population-based study
    J Amar
    Service de Médecine Interne et d Hypertension artérielle, CHU Purpan Toulouse, France
    J Hypertens 19:381-7. 2001
    ..To determine the relationships between pulse wave velocity (PWV), an estimate of arterial distensibility and cardiovascular risk factors...
  73. ncbi Inflammatory response to stent implantation: differences in femoropopliteal, iliac, and carotid arteries
    Martin Schillinger
    Department of Angiology, University of Vienna Medical School, Währinger Gürtel 18 20 6J, 1090 Vienna, Austria
    Radiology 224:529-35. 2002
    To investigate the postintervention course of serum acute-phase reactants after stent implantation in the femoropopliteal, iliac, and carotid arteries.
  74. ncbi Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
    Caroline Cheng
    Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 106:3691-8. 2005
    ..05) compared with nontreated carotid arteries. Colocalization of eNOS-GFP with either the Golgi complex or PECAM-1 also responded to alterations of shear ..
  75. pmc Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries
    Qing H Meng
    Department of Pathology and Laboratory Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK, Canada S7N 0W8
    Am J Pathol 170:1406-14. 2007
    ..15 +/- 0.01 mm(2) versus 0.21 +/- 0.01 mm(2), P < 0.001) of the balloon-injured carotid arteries and reduced the intima/media ratio (1.05 +/- 0.07 versus 1.43 +/- 0.06, P < 0.001)...
  76. ncbi Remodeling of carotid arteries is associated with increased expression of thrombomodulin in a mouse transverse aortic constriction model
    Yi Heng Li
    Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Thromb Haemost 97:658-64. 2007
    ..Doppler (n = 8), morphometric (n = 8), and Q-PCR (n = 8 or 10) studies were performed on carotid arteries at different time points. The RCA lumen and media area increased...
  77. pmc Arterial pulse wave velocity and cognition with advancing age
    Merrill F Elias
    Department of Psychology and Graduate School of Biomedical Sciences, 5472 Little Hall, University of Maine, Orono, ME 04469, USA
    Hypertension 53:668-73. 2009
    ..Early interventions to prevent an increase in arterial stiffness could possibly play an important role in the preservation of cognitive ability...
  78. doi A state of the art review on intima-media thickness (IMT) measurement and wall segmentation techniques for carotid ultrasound
    Filippo Molinari
    BioLab, Department of Electronics, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin, Italy
    Comput Methods Programs Biomed 100:201-21. 2010
    ..developed so far to perform computer-based segmentation and intima-media thickness (IMT) measurement of the carotid arteries in ultrasound images...
  79. pmc Clinical implications of discordance between low-density lipoprotein cholesterol and particle number
    James D Otvos
    LipoScience, Inc, Raleigh, NC, USA
    J Clin Lipidol 5:105-13. 2011
    ..This variability causes concentrations of LDL cholesterol (LDL-C) and LDL particles (LDL-P) to be discordant in many individuals...
  80. doi Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium
    Zhe Zhou
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany
    Cell Metab 13:592-600. 2011
    ..Thus, atherogenic monocyte recruitment mediated by hyperlipidemia and modified LDL crucially depends on LPA, which triggers endothelial deposition of CXCL1, revealing LPA signaling as a target for cardiovascular disease treatments...
  81. pmc In-vivo quantitative T2 mapping of carotid arteries in atherosclerotic patients: segmentation and T2 measurement of plaque components
    Luca Biasiolli
    Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 15:69. 2013
    Atherosclerotic plaques in carotid arteries can be characterized in-vivo by multicontrast cardiovascular magnetic resonance (CMR), which has been thoroughly validated with histology...
  82. doi Autonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors
    Carmine Pizzi
    Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, Italy
    Atherosclerosis 212:292-8. 2010
    ....
  83. doi Impact of plaque haemorrhage and its age on structural stresses in atherosclerotic plaques of patients with carotid artery disease: an MR imaging-based finite element simulation study
    Umar Sadat
    University Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Box 218, Level 5, Hills Road, Cambridge CB2 0QQ, UK
    Int J Cardiovasc Imaging 27:397-402. 2011
    ..with atherosclerotic carotid disease underwent high resolution magnetic resonance (MR) imaging of their carotid arteries in a 1.5 Tesla MR system. Twenty-three patients had MR-identifiable PH and were selected...
  84. pmc Associations of cardiovascular risk factors with two surrogate markers of subclinical atherosclerosis: endothelial function and carotid intima media thickness
    Kathleen V Fitch
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Atherosclerosis 217:437-40. 2011
    ..Endothelial function and carotid intima media thickness (cIMT) were investigated in a cohort of 54 healthy adults without known cardiovascular disease...
  85. ncbi Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries
    Kristen M Park
    Ion Channel and Calcium Signaling Unit, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Heart Circ Physiol 294:H1183-7. 2008
    ..A2 (iPLA2)-mediated pathway play a crucial role in agonist-induced constriction of cerebral, mesenteric, and carotid arteries. Intracellular Ca2+ in SMC and intraluminal diameter were measured simultaneously in intact pressurized ..
  86. doi Noninvasive real-time imaging of intima thickness after rat carotid artery balloon injury using ultrasound biomicroscopy
    Anton Razuvaev
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Atherosclerosis 199:310-6. 2008
    ..Here, we evaluated the possibility to determine intima thickness in the rat carotid artery after balloon injury and to monitor intimal hyperplasia formation by UBM during pharmacological treatment...
  87. doi High signal intensity halo around the carotid artery on maximum intensity projection images of time-of-flight MR angiography: a new sign for intraplaque hemorrhage
    Yoo Jeong Yim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Magn Reson Imaging 27:1341-6. 2008
    ..To evaluate the value of the high signal intensity halo sign as a new marker of a fresh or recent intraplaque hemorrhage on the maximum intensity projection (MIP) images of time-of-flight (TOF) MR angiography...
  88. doi Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis
    Constantina Masoura
    1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Atherosclerosis 214:129-38. 2011
    ..To evaluate the impact of familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) on arterial properties and the effects of statins...
  89. doi Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging
    Kiyofumi Yamada
    Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
    Atherosclerosis 215:399-404. 2011
    ..The aim of this study was to elucidate the relationship between the tissue components of carotid plaques and the incidence of new ipsilateral silent ischemic lesions (NISIL) after CAS or CEA...
  90. pmc A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries
    Antonio J Lepedda
    Dipartimento di Scienze Fisiologiche, Biochimiche e Cellulari, Universita di Sassari, Via Muroni 25, 07100 Sassari, Italy
    Atherosclerosis 203:112-8. 2009
    ..By using proteomics we isolated and identified proteins that were expressed/retained in stable and unstable human carotid artery atherosclerotic plaques...
  91. doi 3D time-resolved MR angiography (MRA) of the carotid arteries with time-resolved imaging with stochastic trajectories: comparison with 3D contrast-enhanced Bolus-Chase MRA and 3D time-of-flight MRA
    R P Lim
    Department of Radiology, NYU Langone Medical Center, New York, NY, USA
    AJNR Am J Neuroradiol 29:1847-54. 2008
    ..trajectories (TWIST), which uses a spiral trajectory to undersample k-space, to perform time-resolved MRA of the extracranial internal carotid arteries and compare it to time-of-flight (TOF) and high-resolution contrast-enhanced (HR) MRA.
  92. doi "Vascular age" is advanced in children with atherosclerosis-promoting risk factors
    Joseph Le
    School of Medicine and the Department of Mathematics and Statistics, University of Missouri Kansas City and the Department of Pediatrics, Children s Mercy Hospital, Kansas City, MO, USA
    Circ Cardiovasc Imaging 3:8-14. 2010
    ..Adult CIMT percentile tables were used for comparison because normative CIMT data for children are limited...
  93. doi Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries
    Brad R S Broughton
    Dept of Pharmacology, Monash Univ, Clayton, Victoria, Australia
    Am J Physiol Heart Circ Physiol 298:H1055-61. 2010
    ..responses to the GPR30 agonists, G-1 and 5408-0877 (1 nM-10 microM), in U-46619-precontracted common carotid arteries from Sprague-Dawley rats...
  94. pmc Carotid arterial wall characteristics are associated with incident ischemic stroke but not coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study
    Eric Y Yang
    Section of Atherosclerosis and Vascular Medicine, Department of Internal Medicine, Baylor College of Medicine, Houston TX, USA
    Stroke 43:103-8. 2012
    ..We evaluated the association of carotid ultrasound-derived arterial stiffness measures with incident coronary heart disease (CHD) and ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study...
  95. ncbi The effects of obesity and non-pharmacological weight loss on vascular and ventricular function and structure
    M R Skilton
    Department of Medicine, University of Sydney, Sydney, Australia
    Diabetes Obes Metab 10:874-84. 2008
    ..We sought to characterize the preclinical changes in cardiac and vascular health that accompany obesity and the influence of lifestyle modification on these parameters...
  96. doi Country-based reference values and impact of cardiovascular risk factors on carotid intima-media thickness in a French population: the 'Paroi Artérielle et Risque Cardio-Vasculaire' (PARC) Study
    Pierre Jean Touboul
    INSERM U 698, Paris, France
    Cerebrovasc Dis 27:361-7. 2009
    ..To define reference values for mean common carotid artery intima-media thickness (CCAIMT(mean)) from subjects without conventional cardiovascular risk factors...
  97. doi The value of carotid intima-media thickness for predicting cardiovascular risk
    Alain Simon
    Service de Cardiologie Préventive, Hopital Europeen Georges Pompidou, Universite Paris Descartes, INSERM U970, 75015 Paris, France
    Arterioscler Thromb Vasc Biol 30:182-5. 2010
    ....
  98. ncbi Carotid intima-media thickness and its relations with the complications in patients with type 1 diabetes mellitus
    Kamile Gul
    Department of Endocrinology and Metabolism, Ankara Ataturk Education and Research Hospital, Ankara, Turkey
    Anadolu Kardiyol Derg 10:52-8. 2010
    ..In this study, we aimed to evaluate the CIMT in patients with type 1 DM, and its association with diabetic microvascular complications (nephropathy-retinopathy)...
  99. ncbi Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study
    Lloyd E Chambless
    Department of Biostatistics, University of North Carolina, CB 8300, 137 East Franklin Street, Suite 400, Bank of America Center, Chapel Hill, NC 27514 4145, USA
    J Clin Epidemiol 56:880-90. 2003
    ..These factors substantially improved prediction of future CHD for men, less for women, and also increased attributable risks...
  100. ncbi Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device
    Paolo Salvi
    Department of Internal Medicine, Bufalini Hospital, Cesena, Italy
    J Hypertens 22:2285-93. 2004
    ..Its software provides absolute arterial pressure values, an assessment of arterial pulse wave contours, an estimation of reflection waves and measurements of PWV...
  101. ncbi Involvement of the CD1d-natural killer T cell pathway in neointima formation after vascular injury
    Asa Ström
    Department of Experimental Medicine, Lund University, Sweden
    Circ Res 101:e83-9. 2007
    ..The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses...

Research Grants67

  1. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..The vessels will then be implanted as interposition grafts in the carotid arteries of living sheep, and will be imaged in 500[unreadable]m resolution to follow the tissue regeneration and ..
  2. Ralph L Sacco; Fiscal Year: 2014
    ..We have broadened our focus to investigate markers of obesity, subclinical disease measures of the carotid arteries and brain, and predictors of vascular cognitive impairment and decline...
  3. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    Akira Sekikawa; Fiscal Year: 2012
    ..1) the Japanese in Japan had significantly lower levels of subclinical atherosclerosis in the coronary and carotid arteries than US populations, (2) Japanese Americans had similar or higher levels of subclinical atherosclerosis as ..
  4. Raj Kishore; Fiscal Year: 2014
    ..more ethanol compared to those receiving placebo;b) E2-mediated re-endothelialization in denuded carotid arteries and E2-mediated neo-vascularization and blood flow recovery in ischemic hind limbs is blunted in mice ..
  5. Role of miR-145 in Vascular Smooth Muscle Cell BiologyRole of
    Chunxiang Zhang; Fiscal Year: 2013
    ..in VSMC phenotypic modulation, proliferation, migration, and vascular neointimal growth in injured rat carotid arteries in vivo...
  6. Genetic Predisposition for Intimal Hyperplasia in Mice
    Renee C LeBoeuf; Fiscal Year: 2013
    ..by using genetic linkage and association studies to identify genes modulating vascular pathology in carotid arteries. Since the last submission, we have altered the emphasis of our outstanding research team to include family ..
  7. Cellular and molecular mechanisms of preterm white matter injury
    Art Riddle; Fiscal Year: 2013
    ..in which ischemia will be induced in fetuses through the inflation of occluders placed on the bilateral carotid arteries. Acquisition of MRI data, using a Bruker Biospin small animal imaging system that is equipped with an ultra- ..
  8. Role of Ribosomal Proteins in Vascular Smooth Muscle Cell Proliferation
    Elaine M Smolock; Fiscal Year: 2010
    ..Phenotypic analysis of the effect of decreased blood flow in the left carotid arteries of C3HeB/FeJ (C3H/F) showed that these mice are resistant to intima formation when blood flow decreases while ..
  9. Sharon Francis; Fiscal Year: 2014
    ..Further, we found that SGK1 activity is enhanced in injured carotid arteries. To elucidate the molecular mechanism underlying these effects, we conducted a kinase substrate protein ..
  10. PATRICK ANDRIES MURPHY; Fiscal Year: 2014
    ..Examine alternative splicing of fibronectin in response to atheroprone flow in vivo by molecular analysis of carotid arteries experimentally exposed to increased or decreased blood flow...
  11. TGF-beta Complex Serves as a Mechanosensor in the Vascular Wall
    Emily Wilson; Fiscal Year: 2010
    ..b>Carotid arteries from mice that are null for these genes will be used to test whether these proteins contribute to the ..
  12. Transcriptional Regulation and Vascular Protection by IL-10
    Anthony A Cuneo; Fiscal Year: 2012
    ..coronary artery VSMC, and adenoviral delivery of IL-19 reduces intimal hyperplasia in angioplasty injured rat carotid arteries. IL-19 inhibits inflammation-stimulated expression of proliferative and inflammatory gene proteins...
  13. Regulation of eNOS by Shear Stress in Intact Arteries
    Robin C Looft Wilson; Fiscal Year: 2010
    ..Arteries (mesenteric and carotid arteries) will be subjected to various magnitudes of shear stress (with or without specific kinase inhibitors), at ..
  14. Neurodevelopmental Outcomes in Infants with HLHS after Hybrid Stage I Palliation
    Sharon L Hill; Fiscal Year: 2011
    ..upon the blood flow through the stented patent ductus arteriosus and retrograde aortic arch flow to the carotid arteries, similar to fetal life, for approximately 6 months of age when the next staged repair is performed...
  15. ARFI ultrasound for noninvasive, Diagnostic atherosclerosis imaging
    Caterina M Gallippi; Fiscal Year: 2013
    ..ARFI plaque detection and compositional assessment may be validated in FH pig iliac arteries and in human carotid arteries.
  16. Syndecan-1 and the Arterial Response to Injury
    Alexander W Clowes; Fiscal Year: 2013
    ..We have recently found that intimal thickening and medial proliferation are markedly increased in the injured carotid arteries of syndecan-1 null mice...
  17. ELAINE MOTT URBINA; Fiscal Year: 2015
    ..The central hypothesis for this proposal is that more rapid CV aging (thicker heart and carotid arteries, decreased cardiac function, increased arterial stiffness, reduced arterial wall function) will occur over ..
  18. Hai Chao Han; Fiscal Year: 2014
    ..The effect of wall matrix degradation on artery buckling will be evaluated in porcine carotid arteries using elastase and collagenase treatments to degrade specific matrix components...
  19. Suppression of VSMC Activation and Mechanisms of Vascular Protection by IL-19
    Michael V Autieri; Fiscal Year: 2012
    ..transfer significantly reduces neointimal formation and VSMC proliferation in balloon angioplasty-injured rat carotid arteries. The overall goals of this application are designed to characterize the mechanism of IL -19 suppressive ..
  20. Role of endothelins in SCG axon guidance
    Takako Makita; Fiscal Year: 2011
    ..to address and extend a model in which endothelin signaling, emanating from smooth muscle ofthe external carotid arteries, is a required guidance cuefdrSCG axons...
  21. O-GlyNAcylation: Novel Mechanism of Estrogen-Induced Vasoprotection
    Suzanne Oparil; Fiscal Year: 2012
    ..amino-N-phenylcarbamate (PUGNAc), has anti-inflammatory effects in balloon injured rat carotid arteries. These novel observations provide provocative evidence that enhanced O-GlcNAc modification of proteins has ..
  22. Kris Moe; Fiscal Year: 2014
    ..middle skull base are diverse in their etiology and cause significant morbidity due to close proximity to the carotid arteries, brain, orbits, optic nerves and chiasm...
  23. Christopher N Wyatt; Fiscal Year: 2014
    ..AMP-activated protein kinase and oxygen-sensing Abstract The carotid bodies are small organs located on the carotid arteries. They serve an essential biological function by detecting and relaying information regarding blood gas ..
  24. Peter J Gianaros; Fiscal Year: 2016
    ..to acute psychological stressors is associated with an increased risk for preclinical atherosclerosis in the carotid arteries, a known predictor of premature disability and death by coronary heart disease (CHD)...
  25. Oxidized Phospholipid-Induced Inflammation in Atherosclerosis
    Norbert Leitinger; Fiscal Year: 2010
    ..To mimic accumulation of OxPL in the vascular wall, we will topically apply OxPL to carotid arteries in mice and measure chemokine and adhesion molecule expression...
  26. Carotid plaque characteristics by MRI in AIM-HIGH
    Xue Qiao Zhao; Fiscal Year: 2012
    ..alone, intensive LDL-lowering plus HDL-raising therapy decreases the mean plaque lipid composition in carotid arteries assessed by MRI...
  27. High-Performance Cone-Beam CT Guidance of Head and Neck Surgery
    Jeffrey H Siewerdsen; Fiscal Year: 2010
    ..g., the optic nerves, carotid arteries and brain) poses a major challenge to surgical performance in the absence of intraoperative imaging...
  28. ROBERT JAMES WEBSTER; Fiscal Year: 2016
    ..g. enable physicians to resect tumors by curving around the carotid arteries), while providing the physician with a comfortable and intuitive control interface conceptually similar to ..
  29. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010
    ..Studies in specific aim 1 will further determine the role of MPO on neointima formation in rat carotid arteries after balloon injury...
  30. Stephen J Riederer; Fiscal Year: 2015
    ..performed during Years 20- 23 we will generate high quality images of the vasculature of the aortic arch, carotid arteries, intracranial arteries, and the draining veins of he brain in one comprehensive exam...
  31. Quantitative High Resolution Human Brain PET Imaging
    Richard E Carson; Fiscal Year: 2010
    ..3: Develop and validate methods to extract the arterial input function using image-based measurements of the carotid arteries and suitable brain reference regions...
  32. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
    ..mammalian sterile 20 like kinase 1 (Mst1) strongly prevents neointimal thickening in rat balloon-injured carotid arteries. Mst1 is a serine threonine kinase having versatile functions, including apoptosis and suppression of cell ..
  33. HDL AND PLAQUES--NOVEL MODELS AND IMAGING TECHNIQUES
    Edward Fisher; Fiscal Year: 2001
    ..patients with dyslipidemia and patients with stroke will be screened for plaques in the thoracic aorta and carotid arteries. Plasma lipid levels will be modified by therapy with a statin or statin plus niacin (to raise HDL) and ..
  34. Site-specific delivery of photosensitizer and singlet oxygen in vivo
    Alexander Greer; Fiscal Year: 2013
    ..or unsafe for treatment by traditional surgical and medical methods include major blood vessels such as the carotid arteries, critical areas of the brain, and portions of the eye...
  35. DYNAMICS OF RETINOPATHY AMONG MEXICAN AMERICAN DIABETICS
    Craig Hanis; Fiscal Year: 1990
    ..blood glucose, glycosylated hemoglobin, and linoleic acid level determinations; ultrasound examination of the carotid arteries; and collection of historical information...
  36. Daniel J Taylor; Fiscal Year: 2014
    ..Atherosclerosis will be assessed with 2D ultrasound imaging of the carotid arteries. The carotid ultrasound scan and EMA/ambulatory protocol will be performed at study entry and at a 2 year ..
  37. BIOLOGICAL FACTORS RESPONSIBLE FOR NEUROBEHAVIORAL AGING
    CONSTANCE MEYD; Fiscal Year: 1991
    ..The quantity and composition of atherosclerotic plaque in the carotid arteries will be quantitated with duplex scanning...
  38. Role of endothelins in SCG axon guidance
    Takako Makita; Fiscal Year: 2009
    ..to address and extend a model in which endothelin signaling, emanating from smooth muscle of the external carotid arteries, is a required guidance cue for SCG axons...
  39. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..will utilize an innovative approach which employs syngeneic fibroblasts derived from the adventitia of rat carotid arteries and stably transduced (retrovirally mediated) with a beta-galactosidase (lacZ) reporter gene to define ..
  40. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    ..During phase II, (1996-99) they investigated the prevalence of subclinical atherosclerosis (SCA) of the carotid arteries in women 30+ years of age from the original cohort...
  41. CEREBROVASCULAR TIME RESOLVED CONTRAST ENHANCED 3D MRA
    Patrick Turski; Fiscal Year: 1999
    ..The technique provides a series of 3D images with sufficient temporal resolution to separate the carotid arteries from the jugular veins...
  42. 3T Atherosclerotic MRI and Carotid Artery Scoring System
    Chun Yuan; Fiscal Year: 2009
    ..Optimize MRI techniques for probing the luminal surface conditions and tissue composition of atherosclerotic carotid arteries on 3T. 2...
  43. LASER BALLOON ANGIOPLASTY
    James Spears; Fiscal Year: 1990
    ..Initial results of studies of postmortem human atherosclerotic arteries and of normal canine carotid arteries in vivo indicate that LBA is effective in achieving these effects and that it is well tolerated acutely and ..
  44. Endothelial Function in the Cerebral Circulation
    Frank Faraci; Fiscal Year: 2009
    ..Effects of Ang II on endothelial function appear to be greater in cerebral arteries than in carotid arteries or aorta...
  45. INTIMAL THICKENING & ANTITOXIDANTS IN HISPANICS & ANGLOS
    James Dwyer; Fiscal Year: 2003
    ..3 year change in the intima-media thickness (IMT) of the common carotid arteries, causal interpretation of which is supported by the findings that lutein inhibits monocyte attraction by LDL ..
  46. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2006
    ..histological methods to define hypertrophy, and biochemical methods to quantitate superoxide levels in carotid arteries and cerebral arterioles of genetically-altered mice that are deficient in the NADPH oxidase subunit, gp91phox,..
  47. TRIAL OF LOVASTATIN AND ASPIRIN IN ATHEROSCLEROSIS
    Curt Furberg; Fiscal Year: 1992
    ..over an average treatment period of three years, retards the progression of atherosclerotic plaques in the carotid arteries of high risk individuals with asymptomatic carotid stenosis...
  48. ATHEROSCLEROSIS AND RISK OF AGE-RELATED MACULOPATHY
    KAREN CRUICKSHANKS; Fiscal Year: 2002
    ..Generalized atherosclerosis will be measured by intima-medial thickness and the presence of plaque in the carotid arteries. Stored videotapes of B mode ultrasound scans of the carotid arteries were obtained as of the Epidemiology of ..
  49. Ethanol mediated endothelial injury and dysfunction
    Raj Kishore; Fiscal Year: 2007
    ..that chronic ethanol feeding in mice delays endothelial recovery and enhances intimal hyperplasia in denuded carotid arteries. At least, part of ethanol responses are mediated via TNF since TNFRI null mice are protected from ethanol-..
  50. RAPID MR ANGIOGRAPHY WITH REDUCED ARTIFACT
    JAMES PIPE; Fiscal Year: 2000
    ..Applications will be in the carotid arteries and peripheral vasculature, although improvements in pulse sequence design may well be useful in other MRA ..
  51. BRAIN BLOOD FLOW AND METABOLISM IN HYPOXIA-ISCHEMIA
    MYRON GINSBERG; Fiscal Year: 1980
    ..High-grade cerebral ischemia will be produced by occlusion of the basilar and both common carotid arteries and mild hemorrhagic hypotension, resulting in an isoelectric electroencephalogram...
  52. Vascular Function in SOD2-deficient Mice
    Jon Andresen; Fiscal Year: 2003
    ..Studies are planned in the aortae and carotid arteries of wild-type control and SOD2+/- mice because diseases such as hypertension and atherosclerosis, which affect ..
  53. MAPK IN THE CONTRACTILE PHENOTYPE OF SMOOTH MUSCLE
    JOHN BADWEY; Fiscal Year: 2000
    ..h-Caldesmon is phosphorylated in resting porcine carotid arteries and the stoichiometry of phosphorylation increases in response to pharmacological stimulation suggesting that ..
  54. Fibrillin-1 and Pressure-induced Arterial Remodeling
    Emily Wilson; Fiscal Year: 2005
    ..This exploratory grant will utilize a novel computer-controlled system designed to culture mouse carotid arteries ex vivo for days under precise mechanical environments (pressure, flow and stretch) to study interactions ..
  55. QTL analysis of carotid atherosclerosis
    Weibin Shi; Fiscal Year: 2007
    ..mice on the C57BL/6 (B6) genetic background develop all phases of atherosclerotic lesions seen in humans in carotid arteries. Our recent studies show that the lesions can be dramatically diminished by outcross with C3H/HeJ (C3H) mice, ..
  56. MATRIX METALLOPROTEINASE-9 AND ARTERIAL REMODELING
    Zorina Galis; Fiscal Year: 2004
    ..We will examine remodeling of mouse carotid arteries triggered by flow cessation, a model selected based on robust induction of intimal hvperplasia and lumen ..
  57. GLYCEMIA AND RELATED MECHANISMS OF MACROVASCULAR DISEASE
    Lynne Wagenknecht; Fiscal Year: 1999
    ..Atherosclerosis was assessed at the baseline examination via high resolution B-mode ultrasound imaging of the carotid arteries. Insulin sensitivity was assessed using the 'frequently sampled intravenous glucose tolerance test' (FSIGT) ..
  58. EPIDEMIOLOGY OF QUALITY OF LIFE AND AGING
    George Kaplan; Fiscal Year: 1999
    ..Data from extensive laboratory tests, medical history, ultrasonographic examination of the carotid arteries, maximal exercise testing, and extensive spirometry are also available...
  59. New Tracking Approach for 3D Vascular Ultrasound
    WESTLEY ASHE; Fiscal Year: 2003
    ..Sites of particular interest are (1.) carotid arteries for risk of stroke, (2.) lower-limb bypass grafts for risk of limb loss, and (3...
  60. PREVALENCE & PROGRESSION OF SUBCLINICAL ATHEROSCLEROSIS
    KIM TYRRELL; Fiscal Year: 2003
    ..vascular function and accelerates the development of atherosclerosis in the coronary arteries, aorta and carotid arteries will be evaluated...
  61. THREE VESSEL RISK FACTOR ANALYSIS COMPLETION OF CLAS
    Stanley Azen; Fiscal Year: 1993
    ..trial providing information on human atherosclerosis regression/progression in coronary, femoral, and carotid arteries. Two and four year endpoint data have been collected for coronary (panel reading and image processed), ..
  62. NMR STUDIES OF LIPIDS IN DISEASES
    James Hamilton; Fiscal Year: 2000
    ..Plaques from coronary arteries, carotid arteries, and vein grafts that have failed as a result os lipid accumulation will be studied...
  63. PREVALENCE & PROGRESSION OF SUBCLINICAL ATHEROSCLEROSIS
    Lynda Powell; Fiscal Year: 2003
    ..vascular function and accelerates the development of atherosclerosis in the coronary arteries, aorta and carotid arteries will be evaluated...
  64. TRANSCRIPTIONAL CONTROL OF CARDIOVASCULAR PATHOLOGY
    Kenneth Walsh; Fiscal Year: 2001
    ..Similarly, expression of gax is rapidly downregulated in rat carotid arteries following an injury that stimulates VSMC proliferation...
  65. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2004
    ..an interview and physical examination, a resting 12-lead electrocardiogram (ECG), B-mode ultrasound of the carotid arteries, retrospectively gated helical CT (RGHCT), and a spectrum of clinical laboratory measures...