adherens junctions

Summary

Summary: Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of MICROFILAMENTS attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.

Top Publications

  1. ncbi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
  2. ncbi Cadherin switching
    Margaret J Wheelock
    University of Nebraska Medical Center, Department of Oral Biology and Eppley Cancer Center, Omaha, NE 68198 7696, USA
    J Cell Sci 121:727-35. 2008
  3. pmc Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
    Buzz Baum
    University College London, London WC1E 6BT, England, UK
    J Cell Biol 192:907-17. 2011
  4. ncbi Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
  5. pmc Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner
    Quint le Duc
    Hubrecht Institute, University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands
    J Cell Biol 189:1107-15. 2010
  6. pmc Pulsed contractions of an actin-myosin network drive apical constriction
    Adam C Martin
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 457:495-9. 2009
  7. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
  8. pmc Integration of contractile forces during tissue invagination
    Adam C Martin
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 188:735-49. 2010
  9. ncbi Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 13:529-40. 2011
  10. pmc Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping
    Katsutoshi Taguchi
    RIKEN Center for Developmental Biology, Minatojima Minamimachi, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 194:643-56. 2011

Detail Information

Publications261 found, 100 shown here

  1. ncbi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
    ..Endothelial permeability is regulated in part by the dynamic opening and closure of cell-cell adherens junctions (AJs)...
  2. ncbi Cadherin switching
    Margaret J Wheelock
    University of Nebraska Medical Center, Department of Oral Biology and Eppley Cancer Center, Omaha, NE 68198 7696, USA
    J Cell Sci 121:727-35. 2008
    The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another...
  3. pmc Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
    Buzz Baum
    University College London, London WC1E 6BT, England, UK
    J Cell Biol 192:907-17. 2011
    ..This turnover contributes to junction formation and to the maintenance of epithelial integrity during tissue homeostasis and remodeling...
  4. ncbi Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
    ..b>Adherens junctions (AJs) and the cadherin-catenin complexes at their core are therefore the subjects of intense research...
  5. pmc Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner
    Quint le Duc
    Hubrecht Institute, University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands
    J Cell Biol 189:1107-15. 2010
    ..These findings have implications for barrier function, morphogenesis, cell migration, and invasion and may extend to all soft tissues in which classical cadherins regulate cell-cell adhesion...
  6. pmc Pulsed contractions of an actin-myosin network drive apical constriction
    Adam C Martin
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 457:495-9. 2009
    ..purse-string-like contraction of a circumferential actin and non-muscle myosin-II (myosin) belt underlying adherens junctions. However, it is unclear whether other force-generating mechanisms can drive this process...
  7. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
    ..In the endothelium, junctional complexes comprise tight junctions, adherens junctions, and gap junctions...
  8. pmc Integration of contractile forces during tissue invagination
    Adam C Martin
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 188:735-49. 2010
    ..Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis...
  9. ncbi Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 13:529-40. 2011
    ..Finally, we provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin...
  10. pmc Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping
    Katsutoshi Taguchi
    RIKEN Center for Developmental Biology, Minatojima Minamimachi, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 194:643-56. 2011
    ..These findings suggest that epithelial cells remodel their junctional architecture by responding to mechanical forces, and the αE-catenin-bound EPLIN acts as a mechanosensitive regulator for this process...
  11. ncbi Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts
    Wenxiang Meng
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Cell 135:948-59. 2008
    ..We propose that the PLEKHA7/Nezha/MT complex regulates the ZA integrity by recruiting KIFC3 to this junctional site...
  12. ncbi Sticky business: orchestrating cellular signals at adherens junctions
    Mirna Perez-Moreno
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 112:535-48. 2003
    ..are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, ..
  13. pmc Mechanical tugging force regulates the size of cell-cell junctions
    Zhijun Liu
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:9944-9. 2010
    ..To investigate the responsiveness of adherens junctions (AJ) to force, we adapted a system of microfabricated force sensors to quantitatively report cell-cell ..
  14. pmc Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
    Andrea Hartsock
    Departments of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5430, USA
    Biochim Biophys Acta 1778:660-9. 2008
    b>Adherens junctions and Tight junctions comprise two modes of cell-cell adhesion that provide different functions...
  15. ncbi Tight junctions/adherens junctions: basic structure and function
    Carien M Niessen
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:2525-32. 2007
    ..The current review provides an overview of the crucial molecular constituents of these structures and highlights some recent results on their regulation. In particular, I will discuss their importance in skin biology...
  16. pmc Links between signal transduction, transcription and adhesion in epithelial bud development
    Colin Jamora
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nature 422:317-22. 2003
    ....
  17. pmc The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins
    Oliver J Harrison
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    Structure 19:244-56. 2011
    b>Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains extended from opposing cell surfaces...
  18. pmc Differential regulation of adherens junction dynamics during apical-basal polarization
    Juan Huang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    J Cell Sci 124:4001-13. 2011
    b>Adherens junctions (AJs) in epithelial cells are constantly turning over to modulate adhesion properties under various physiological and developmental contexts, but how such AJ dynamics are regulated during the apical-basal polarization ..
  19. ncbi Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis
    Milena Pellikka
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nature 416:143-9. 2002
    ..Defects in such scaffolds may contribute to human CRB1-related retinal dystrophies...
  20. pmc Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
    Kaelyn D Sumigray
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 199:513-25. 2012
    ..assay, we show that cortical microtubules recruit myosin II to the cell cortex in order to engage adherens junctions, resulting in an increase in mechanical integrity of the cell sheets...
  21. pmc Desmosomes: new perpetrators in tumour suppression
    Rachel L Dusek
    Department of Radiation Oncology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nat Rev Cancer 11:317-23. 2011
    b>Adherens junctions, which are intercellular adhesive complexes that are crucial for maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour progression...
  22. ncbi Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells
    Mathieu Boissan
    UPMC Universite Paris 06, Paris, France
    Cancer Res 70:7710-22. 2010
    ....
  23. pmc EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
    Kentaro Abe
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:13-9. 2008
    ....
  24. ncbi Cadherin-actin interactions at adherens junctions
    Shigenobu Yonemura
    Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, 650 0047, Japan
    Curr Opin Cell Biol 23:515-22. 2011
    ..Here, I provide an overview of cadherin-actin interaction from morphological aspects and of possible molecular mechanisms revealed by recent studies...
  25. ncbi folded gastrulation, cell shape change and the control of myosin localization
    Rachel E Dawes-Hoang
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544, USA
    Development 132:4165-78. 2005
    ..a flattening and constriction of the cell surface through a tethering of the actinomyosin cytoskeleton to the apical adherens junctions. Our analysis of fog function therefore provides a direct link from patterning to cell shape change.
  26. ncbi Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2
    Verena Kölsch
    Institute of Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Science 315:384-6. 2007
    ..Together with G protein signaling, T48 recruits adherens junctions and the cytoskeletal regulator RhoGEF2 to the sites of apical constriction, ensuring rapid and intense ..
  27. pmc A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens
    Suzie Verma
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, St Lucia, Brisbane 4072, Australia
    Mol Biol Cell 23:4601-10. 2012
    ..WAVE2-Arp2/3 disruption depleted junctions of both myosin IIA and IIB, suggesting that dynamic actin assembly may support junctional tension by facilitating the local recruitment of myosin...
  28. ncbi Rap1: a key regulator in cell-cell junction formation
    Matthijs R H Kooistra
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Cell Sci 120:17-22. 2007
    ..Indeed, inhibition of Rap1 generates immature adherens junctions, whereas activation of Rap1 tightens cell-cell junctions...
  29. pmc A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension
    Jessica K Sawyer
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 22:2491-508. 2011
    ..We propose a model in which an actomyosin network linked at AP AJs by Canoe and coupled to apical polarity proteins regulates convergent extension...
  30. pmc Discovering the molecular components of intercellular junctions--a historical view
    Werner W Franke
    Helmholtz Group for Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cold Spring Harb Perspect Biol 1:a003061. 2009
    ..three decades: Desmosomes, which connect epithelial and some other cell types, and the almost ubiquitous adherens junctions are based on closely cis-packed glycoproteins, cadherins, which are associated head-to-head with those of ..
  31. ncbi Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells
    Tatsuhiro Sato
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:5288-99. 2006
    ..adhesion and then assembles cadherin at nectin-based cell-cell adhesion sites, resulting in the formation of adherens junctions (AJs). Afadin is a nectin- and actin filament-binding protein that connects nectin to the actin cytoskeleton...
  32. ncbi ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 4:408-15. 2002
    b>Adherens junctions (AJs) are crucial for maintaining the integrity of epithelial tissues and are often disrupted during tumour progression. Rho family proteins have been shown to regulate adherens junctions...
  33. pmc Adherens junctions connect stress fibres between adjacent endothelial cells
    Jaime Millan
    University College London, Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, London WC1E6BT, UK
    BMC Biol 8:11. 2010
    ..However, in the endothelium, cell-cell junctions are highly dynamic and morphologically heterogeneous...
  34. pmc An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration
    F Palacios
    Department of Biological Sciences and the Walther Cancer Institute, University of Notre Dame, Notre Dame, IN 46556-0369, USA
    EMBO J 20:4973-86. 2001
    ..Finally, we show that ARF6 exerts its role downstream of v-Src activation during the disassembly of AJs. These findings document an essential role for ARF6- regulated membrane traffic in AJ disassembly and epithelial cell migration...
  35. pmc The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species
    Elizabeth Monaghan-Benson
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 284:25602-11. 2009
    ..Collectively, these data suggest that VEGF leads to a Rac-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity...
  36. ncbi alpha-Catenin as a tension transducer that induces adherens junction development
    Shigenobu Yonemura
    Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 12:533-42. 2010
    b>Adherens junctions (AJs), which are organized by adhesion proteins and the underlying actin cytoskeleton, probably sense pulling forces from adjacent cells and modulate opposing forces to maintain tissue integrity, but the regulatory ..
  37. pmc Structure and biochemistry of cadherins and catenins
    Lawrence Shapiro
    Department of Biochemistry and Molecular Biophysics and Edward S Harkness Eye Institute, Columbia University, New York, New York 10032, USA
    Cold Spring Harb Perspect Biol 1:a003053. 2009
    Classical cadherins mediate specific adhesion at intercellular adherens junctions. Interactions between cadherin ectodomains from apposed cells mediate cell-cell contact, whereas the intracellular region functionally links cadherins to ..
  38. pmc Molecular bases of cell-cell junctions stability and dynamics
    Matthieu Cavey
    IBDML, UMR CNRS Université de la Méditerranée, Marseille, France
    Cold Spring Harb Perspect Biol 1:a002998. 2009
    Epithelial cell-cell junctions are formed by apical adherens junctions (AJs), which are composed of cadherin adhesion molecules interacting in a dynamic way with the cortical actin cytoskeleton...
  39. ncbi Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function
    Laura Fernández-Martín
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Arterioscler Thromb Vasc Biol 32:e90-102. 2012
    ..b>Adherens junctions (AJ) play a central role in regulating this barrier...
  40. ncbi CCM1 regulates vascular-lumen organization by inducing endothelial polarity
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    J Cell Sci 123:1073-80. 2010
    ..In this paper we show that lumen formation correlates with endothelial polarization. Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5) are required for endothelial apicobasal polarity in vitro and ..
  41. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
    In developing mammalian telencephalon, the loss of adherens junctions and cell cycle exit represent crucial steps in the differentiation of neuroepithelial cells into neurons, but the relationship between these cellular events remains ..
  42. pmc Differential positioning of adherens junctions is associated with initiation of epithelial folding
    Yu Chiun Wang
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 484:390-3. 2012
    ..Here we describe an alternative mechanism that requires differential positioning of adherens junctions controlled by modulation of epithelial apical-basal polarity...
  43. ncbi Working out the strength and flexibility of desmosomes
    Spiro Getsios
    Department of Pathology, Robert H Lurie Cancer Center, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 5:271-81. 2004
  44. ncbi N-glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435
    Hongbo Zhao
    Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China
    J Cell Biochem 104:162-75. 2008
    ..Analysis of the composition of adherens junctions (AJs) revealed that removal of N-glycans on E-cadherin resulted in elevated tyrosine phosphorylation level ..
  45. pmc Spontaneous assembly and active disassembly balance adherens junction homeostasis
    Soonjin Hong
    Department of Dermatology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:3528-33. 2010
    The homeostasis of adherens junctions was studied using E-cadherin and its two mutants tagged by the photoconvertible protein Dendra2 in epithelial A-431 cells and in CHO cells lacking endogenous cadherin...
  46. pmc Molecular components of the adherens junction
    Carien M Niessen
    Center for Molecular Medicine, University of Cologne, LFI, 05, Room 59, Joseph Stelzmannstrasse 9, D 50931 Cologne, Germany
    Biochim Biophys Acta 1778:562-71. 2008
    b>Adherens junctions serve to couple individual cells into various arrangements required for tissue structure and function...
  47. ncbi Effects of indoxyl sulfate on adherens junctions of endothelial cells and the underlying signaling mechanism
    Yu Sen Peng
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 113:1034-43. 2012
    ..This study explored the effects of IS on the adherens junctions of vascular endothelial cells and revealed the underlying mechanism...
  48. ncbi Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts
    Ruei Jiun Hung
    Lombardi Cancer Center, Georgetown Univ Medical Center 3970 Reservoir Rd NW, Washington, DC 20057 1412, USA
    Am J Physiol Cell Physiol 286:C1159-69. 2004
    ..Concomitantly, S1P induced assembly of adherens junctions and subcortical actin belts...
  49. ncbi Desmoplakin is essential in epidermal sheet formation
    V Vasioukhin
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Cell Biol 3:1076-85. 2001
    ..b>Adherens junctions are also reduced. In vitro, DP transgene expression rescues these defects...
  50. pmc Caveolae mediate growth factor-induced disassembly of adherens junctions to support tumor cell dissociation
    Lidiya Orlichenko
    Mayo Clinic, Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Rochester, MN 55905, USA
    Mol Biol Cell 20:4140-52. 2009
    ..Together, these findings provide new insights into how cells might disassemble cell-cell contacts to help mediate the remodeling of adherens junctions, and tumor cell metastasis and invasion.
  51. ncbi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..Although formed by different molecules, tight junctions (TJs) and adherens junctions (AJs) are functionally and structurally linked, but the signalling pathways behind this interaction are ..
  52. pmc Adherens junction: molecular architecture and regulation
    Wenxiang Meng
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Cold Spring Harb Perspect Biol 1:a002899. 2009
    ..Thus, elucidating the molecular architecture of the AJs and their regulatory mechanisms are crucial for understanding how the multicellular system is organized...
  53. pmc Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm
    Jeremiah F Roeth
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS ONE 4:e7634. 2009
    ..Tissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this plasticity in cell adhesion involves regulated trafficking of junctional proteins...
  54. ncbi Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells
    Michael Shtutman
    Cancer Center, Ordway Research Institute, Albany, New York 12208, USA
    Cancer Res 66:11370-80. 2006
    The first steps of invasion and metastasis include the dissociation of adherens junctions and the induction of migratory phenotype, through a program that resembles epithelial-mesenchymal transition (EMT)...
  55. ncbi Adherens junction assembly and function in the Drosophila embryo
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Canada
    Int Rev Cell Mol Biol 293:45-83. 2012
    b>Adherens junctions are essential for the development and physiology of epithelial tissues. The Drosophila embryo is an excellent model for understanding adherens junction assembly, maintenance, and regulation during tissue development...
  56. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    ..The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120...
  57. pmc Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin
    Xiao Peng
    Department of Biochemistry, University of Iowa Roy J Carver College of Medicine, Iowa City, IA 52242, USA
    J Cell Sci 123:567-77. 2010
    Vinculin was identified as a component of adherens junctions 30 years ago, yet its function there remains elusive. Deletion studies are consistent with the idea that vinculin is important for the organization of cell-cell junctions...
  58. pmc α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction
    Vivian W Tang
    Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
    J Cell Biol 196:115-30. 2012
    ..These findings demonstrate that α-actinin-4 plays an important role in coupling actin nucleation to assembly at cadherin-based cell-cell adhesive contacts...
  59. pmc Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools
    Yoonseok Kam
    Cancer Biology Department, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 4:e4580. 2009
    Beta-catenin is an essential component of two cellular systems: cadherin-based adherens junctions (AJ) and the Wnt signaling pathway...
  60. ncbi The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface
    Silvia Cappello
    GSF, National Research Center for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Munich, Germany
    Nat Neurosci 9:1099-107. 2006
    ..orientation of cell division and basement membrane contact, the apical location of the Par complex and adherens junctions are gradually lost, leading to an increasing failure of apically directed interkinetic nuclear migration...
  61. pmc p120-catenin mediates inflammatory responses in the skin
    Mirna Perez-Moreno
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 124:631-44. 2006
    ..Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function...
  62. ncbi Establishment and characterization of cultured epithelial cells lacking expression of ZO-1
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:44785-94. 2004
    ..cells at the initial phase of polarization, these proteins are recruited to cadherin-based spotlike adherens junctions (AJs)...
  63. pmc The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions
    Rie Yamamura
    Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Mol Biol Cell 19:971-83. 2008
    The assembly of tight junctions (TJs) and adherens junctions (AJs) is regulated by the transport of integral TJ and AJ proteins to and/or from the plasma membrane (PM) and it is tightly coordinated in epithelial cells...
  64. ncbi Establishment of cell polarity by afadin during the formation of embryoid bodies
    Hitomi Komura
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Genes Cells 13:79-90. 2008
    ..directly links nectin, an immunoglobulin-like cell-cell adhesion molecule, to actin filaments (F-actin) at adherens junctions (AJs)...
  65. pmc Crumbs stabilises epithelial polarity during tissue remodelling
    Kyra Campbell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Cell Sci 122:2604-12. 2009
    ....
  66. ncbi Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions
    Letizia Carramusa
    Department of Molecular Cell Biology, The Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    J Cell Sci 120:3870-82. 2007
    ..that short-hairpin (sh) RNA-mediated downregulation of Dia1 in human MCF7 epithelial cells disrupts adherens junctions, as manifested by the significantly decreased localization of E-cadherin and associated proteins to cell-..
  67. ncbi Remodeling of the adherens junctions during morphogenesis
    Tamako Nishimura
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Japan
    Curr Top Dev Biol 89:33-54. 2009
    ..The adherens junctions are required for the firm associations between cells, as disruption of them causes disorganization of the ..
  68. pmc Dimer asymmetry defines α-catenin interactions
    Erumbi S Rangarajan
    Department of Cancer Biology, Scripps Research Institute, Jupiter, Florida, USA
    Nat Struct Mol Biol 20:188-93. 2013
    ..interactions of α-catenin with the cytoskeletal protein vinculin appear to be necessary to stabilize adherens junctions. Here we report the crystal structure of nearly full-length human α-catenin at 3.7-Å resolution...
  69. ncbi Ultrastructure of the zonula adherens revealed by rapid-freeze deep-etching
    K Miyaguchi
    Laboratory of Neurobiology, NINDS, NIH, Bethesda, Maryland 20892, USA
    J Struct Biol 132:169-78. 2000
    ..The freeze-etching also revealed a characteristic particle complex on the ZA cytoplasmic surface, which may represent the cytosolic proteins linking cadherins to actin bundles...
  70. ncbi Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctions
    Mehran Haidari
    Division of Cardiology, Department of Internal Medicine, The University of Texas Health Science Center, 6770 Bertner Ave, C1000, Houston, TX 77030, USA
    Cardiovasc Res 92:456-65. 2011
    ..phosphorylation of vascular endothelial cadherin (VE-cad) has been implicated in the dissociation of adherens junctions and the increased paracellular permeability of endothelial cells (ECs) that occur during TEM of monocytes...
  71. ncbi Down-regulated desmocollin-2 promotes cell aggressiveness through redistributing adherens junctions and activating beta-catenin signalling in oesophageal squamous cell carcinoma
    Wang Kai Fang
    Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, China The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, China
    J Pathol 231:257-70. 2013
    In contrast to the well-recognized loss of adherens junctions in cancer progression, the role of desmosomal components in cancer development has not been well explored...
  72. pmc Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions
    Susann Becker
    Research Laboratories, Department of Surgery, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e8507. 2010
    ..enterocytes as well as in colorectal cell lines CD97 was localized preferentially in E-cadherin-based adherens junctions. CD97 overexpression upregulated membrane-bound but not cytoplasmic or nuclear beta-catenin and reduced ..
  73. ncbi Protein myozap--a late addition to the molecular ensembles of various kinds of adherens junctions
    Steffen Rickelt
    Helmholtz Group for Cell Biology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cell Tissue Res 346:347-59. 2011
    ..plaques of the composite junctions (areae compositae) in the myocardiac intercalated disks and of the adherens junctions (AJs) in vascular endothelia...
  74. ncbi Regulation of adherens junctions by Rho GTPases and p120-catenin
    Andre Menke
    Molecular Oncology of Solid Tumors, Internal Medicine V, Justus Liebig University Giessen, Schubertstr 81, BFS Building, 35392 Giessen, Germany
    Arch Biochem Biophys 524:48-55. 2012
    ..The spatiotemporal regulation of E-cadherin-mediated adherens junctions is essential for normal epithelia function and tissue integrity...
  75. ncbi Adherens junction assembly
    Sergey Troyanovsky
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 60611, Chicago, IL, USA
    Subcell Biochem 60:89-108. 2012
    Classical cadherins are a family of transmembrane proteins that mediate cell-cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster...
  76. pmc The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation
    Ilse Timmerman
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 23:4212-25. 2012
    ..Repair of a dysfunctional endothelial barrier requires controlled restoration of adherens junctions, comprising vascular endothelial (VE)-cadherin and associated β-, γ-, α-, and p120-catenins...
  77. pmc A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, 4 Boulevard d Yvoy, 1205 Geneva, Switzerland
    J Biol Chem 286:16743-50. 2011
    Paracingulin is a 160-kDa protein localized in the cytoplasmic region of epithelial tight and adherens junctions, where it regulates RhoA and Rac1 activities by interacting with guanine nucleotide exchange factors...
  78. ncbi Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine
    S Basuroy
    Dept of Physiology, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 289:G367-75. 2005
    ..These results demonstrate that acetaldehyde induces tyrosine phosphorylation and disrupts tight junction and adherens junction in human colonic mucosa, which can be prevented by EGF and glutamine...
  79. pmc Protein tyrosine phosphatase kappa and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas
    J Schnekenburger
    Department of Medicine B, Westfalische Wilhelms Universitat Munster, Germany
    Gut 54:1445-55. 2005
    ..We have previously shown that cell contacts between pancreatic acinar cells dissociate early in pancreatitis and that this is a prerequisite for the development of pancreatic oedema. Here we studied the underlying mechanism...
  80. ncbi Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche
    Marcus Michel
    Center for Regenerative Therapies Dresden CRTD, TU Dresden, Tatzberg, Germany
    Nat Commun 2:415. 2011
    ..spatial specificity of niche signals is maximized by subcellularly restricting signalling to cadherin-based adherens junctions between individual niche and stem cells...
  81. ncbi Microenvironmental regulation of E-cadherin-mediated adherens junctions
    Klaudia Giehl
    Department of Internal Medicine I, University of Ulm, D 89081 Ulm, Germany
    Front Biosci 13:3975-85. 2008
    ..The reduced cellular adhesion influences the tissue integrity and allows tumor cells to disseminate from the primary tumor representing an early step in cancer metastasis...
  82. ncbi FSH regulates the formation of adherens junctions and ectoplasmic specialisations between rat Sertoli cells in vitro and in vivo
    P Sluka
    Prince Henry s Institute of Medical Research, Level 4, Block E, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Endocrinol 189:381-95. 2006
    ..Adjacent Sertoli cells form a junctional complex that includes classical adherens junctions and testis-specific ectoplasmic specialisations (ES)...
  83. ncbi Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 148:3922-31. 2007
    ..Cadherin 1 and beta-catenin, which form adherens junctions, were abundant in the endometrial glands, but decreased after d 10 of pregnancy in the luminal epithelium ..
  84. ncbi Intercellular adhering junctions with an asymmetric molecular composition: desmosomes connecting Merkel cells and keratinocytes
    Steffen Rickelt
    Helmholtz Group for Cell Biology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cell Tissue Res 346:65-77. 2011
    ..We discuss the developmental, tissue-architectonic and functional importance of such asymmetric junctions in normal physiology as well as in diseases, in particular in the formation of distant tumor cell metastasis...
  85. ncbi Internalization of adhesion junction proteins and their association with recycling endosome marker proteins in rat seminiferous epithelium
    J Nelle S Young
    Department of Cellular and Physiological Sciences, Life Sciences Centre, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Reproduction 143:347-57. 2012
    ....
  86. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
  87. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  88. pmc RAC1 regulates adherens junctions through endocytosis of E-cadherin
    N Akhtar
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Mol Biol Cell 12:847-62. 2001
    ..Our data suggest that Rac1 regulates adherens junctions via clathrin independent endocytosis of E-cadherin.
  89. ncbi Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor
    Taofei Yin
    Department of Pathology and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 280:40355-63. 2005
    ..PG) is a member of the Armadillo family of adhesion/signaling proteins that can be incorporated into both adherens junctions and desmosomes...
  90. ncbi SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1
    Simon A Woodcock
    Cell Signalling Group, Cancer Research UK Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Mol Cell 33:639-53. 2009
    ..Thus, our data implicate Tiam1 phosphorylation and consequent degradation in Src-mediated EMT and resultant cell motility and establish a paradigm for regulating local concentrations of Rho-GEFs...
  91. pmc Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:7607-12. 2011
    ..The organization of neural progenitors in the developing mammalian neuroepithelium is marked by cadherin-based adherens junctions. Whereas RhoA, a founding member of the small Rho GTPase family, has been shown to play important roles in ..
  92. pmc Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus
    Mandana Mansouri
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Virol 82:9615-28. 2008
    ....
  93. ncbi Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function
    Ann M Hopkins
    Department of Pathology and Laboratory Medicine, Emory University, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    J Cell Sci 116:725-42. 2003
    ..In contrast to the TJ, the characteristic ring structure of proteins in adherens junctions (AJs) was largely preserved despite CNF-1 treatment...
  94. ncbi Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells
    Steffen Rickelt
    Helmholtz Group for Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2036-48. 2009
    ..normal and malignantly transformed cells derived from mesenchymal tissues and tumors are connected only by adherens junctions (AJs) containing N-cadherins and/or cadherin-11, anchored in a cytoplasmic plaque assembled by alpha- and ..
  95. pmc Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers
    Alejandro P Adam
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 285:7045-55. 2010
    ....
  96. pmc The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
    Jessica K Sawyer
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 186:57-73. 2009
    Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin-afadin complex also localizes to AJs and links to the cytoskeleton...
  97. pmc Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens
    Michael Smutny
    Institute for Molecular Bioscience, Division of Molecular Cell Biology, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Nat Cell Biol 12:696-702. 2010
    ..We propose that these two isoform-based modules cooperate to coordinate adhesion receptor and F-actin organization to form apical cadherin junctions...
  98. ncbi Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, TX 77030, USA
    Development 130:4363-72. 2003
    Apicobasal cell polarity is crucial for morphogenesis of photoreceptor rhabdomeres and adherens junctions (AJs) in the Drosophila eye...
  99. pmc LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye
    Nancy Amin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:8941-6. 2009
    ..We show that adherens junctions expand and apical, junctional, and basolateral domains mix in lkb1 mutants...
  100. pmc Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
    Hideru Togashi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 174:141-51. 2006
    ..These results suggest that the axon-biased localization of N1 and its trans-interaction with N3 in cooperation with the cadherin machinery is critical for the ordered association of axons and dendrites...
  101. pmc Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy
    Alice E Zemljic-Harpf
    Department of Medicine, UCSD School of Medicine, La Jolla, California, USA
    Mol Cell Biol 27:7522-37. 2007
    ..Prior to the onset of cardiac dysfunction, ultrastructural analysis of cVclKO heart tissue showed abnormal adherens junctions with dissolution of the intercalated disc structure, expression of the junctional proteins cadherin and ..

Research Grants70

  1. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..proposal is focused on vinculin, a cytoskeletal protein that is a prominent component of focal adhesions and adherens junctions. Vinculin is critical for cell migration, cell survival and embryogenesis and disruption of vinculin ..
  2. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..VEGFR2 activation directs the disassembly of EC adherens junctions and induces capillary permeability...
  3. Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular react
    Frank W Sellke; Fiscal Year: 2013
    ..processes including vasomotor regulation and the regulation of vascular permeability mediated through adherens junctions and other endothelial cell-cell contacts...
  4. Probiotics and HIF signaling in Alcoholic Liver Disease
    Wenke Feng; Fiscal Year: 2013
    ..intestinal epithelium is provided by paracellular apical junction complexes, including tight junctions and adherens junctions located at the apical end of epithelial cells, and by mucus layers...
  5. Molecular Control of Gut Permeability in Trauma
    Mack H Wu; Fiscal Year: 2013
    ..of this study lies in the potential to establish a new molecular pathway in the regulation of tight and adherens junctions. Data derived from this study would contribute to the advancement of gastrointestinal surgery with ..
  6. Biology of desmosome-gap junctions in the testis
    Dolores D Mruk; Fiscal Year: 2010
    ..phenomena in cell biology is the adhesion of cells to form an organized epithelium, which is facilitated by adherens junctions and desmosomes...
  7. Cell Adhesion and Cytoskeletal Dynamics in Skin
    Elaine Fuchs; Fiscal Year: 2013
    ..Knowledge of the proteins involved in coordinating actin filament (AF) cytoskeletal dynamics with adherens junctions (AJs) and elucidating how these connections are inversely coordinated with integrin-AF dynamics are key to ..
  8. Acetaldehyde and Epithelial Junctions: Role of PP2A and Occludin Phosphorylation
    MITZI LEE DUNAGAN; Fiscal Year: 2011
    ..My preliminary data suggests that acetaldehyde destabilizes tight junctions and adherens junctions and promotes epithelial- to-mesenchymal transition by a PP2A-dependent mechanism...
  9. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2012
    ..of OxPLs promote the lung vascular barrier integrity via activation of Rap1-dependent engagement of adherens junctions and tight junctions...
  10. The Regulation of Tumor Progression by Endothelial HoxA5
    NANCY JOAN BOUDREAU; Fiscal Year: 2013
    ..HoxA5 also stabilizes EC adherens junctions and reduces endothelial cell permeability...
  11. Endothelial Transmigration in Neovascular Age-related Macular Degeneration
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    ..As a result of CEC-RPE contact, Rap1a has reduced associations with cadherin in adherens junctions, with p22phox, and with protein tyrosine phosphatases, and all these contribute to reduce RPE barrier ..
  12. Molecular control of tissue morphogenesis
    Jennifer A Zallen; Fiscal Year: 2013
    ..Cell rearrangements in epithelial tissues are constrained by a network of adherens junctions between cells whose continuity is maintained throughout elongation...
  13. FRET Imaging of Molecular Hierarchy at Subcellular Levels in Mechanotransduction
    Yingxiao Wang; Fiscal Year: 2013
    ..The activated Src can enhance the MLCK-mediated actomyosin contractility to modulate adherens junctions (AJs), which can affect endothelium permeability and consequently atherosclerosis...
  14. Redox Regulation of the rho-GTPases in the vasculature
    Sharon L Campbell; Fiscal Year: 2012
    ..function in response to hypoxia and ischemia/reoxygenation via remodeling of the actin cytoskeleton and adherens junctions in a ROS-dependent manner...
  15. Incorporation of Endothelial Progenitor Cells into Placental Vaculature
    Greg A Johnson; Fiscal Year: 2013
    ..e., gap, tight and adherens junctions) to incorporate into growing vessels...
  16. Junctional exocytosis and breakdown of the intestinal barrier in inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2013
    ..intestinal barrier is caused by disassembly of specialized epithelial structures, tight junctions (TJs) and adherens junctions (AJs)...
  17. The role of MID1/MID2 in regulating epithelial adhesion
    CATHERINE KOTO; Fiscal Year: 2013
    ..E-cadherin endocytosis and thus the maintenance and dynamic control of apical cell-cell junctions including adherens junctions. In this proposal plan, intercellular forces in epithelial cells will be quantified in cels expressing ..
  18. Proteolysis of cadherins in cranial neural crest
    ANDREW THOMAS SCHIFFMACHER; Fiscal Year: 2013
    ..to this goal, we propose to investigate the mechanisms promoting the disassembly of premigratory NCC adherens junctions to facilitate cadherin switching, a common molecular event that underlies EMTs in NCCs and other cell types...
  19. Actin dynamics and regulation of epithelial barrier in intestinal inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2013
    ..integrity of the epithelial barrier is regulated by cellular structures known as tight junctions (TJs) and adherens junctions (AJs)...
  20. Biophysical Mechanisms of Drosophila Development.
    Jennifer A Zallen; Fiscal Year: 2013
    ..Cell intercalation in epithelial tissues occurs in the presence of a networkof adherens junctions that transmits mechanical forces between cells and maintains its integrity as cells make and break contacts ..
  21. STRUCTURAL DYNAMICS OF VINCULIN IN ADHESION JUNCTIONS
    Tina Izard; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The formation of cell-matrix (focal adhesions) and cell-cell (adherens junctions) adhesion complexes links signals at the cell surface to the actin cytoskeleton, and these direct cell migration, cell ..
  22. srGAP and the cadherin complex during morphogenesis in C. elegans
    JEFFREY D HARDIN; Fiscal Year: 2013
    ..test a model in which [unreadable]-catenin and SRGP-1 act together to promote maturation and maintenance of adherens junctions in the following specific aims: Aim 1: Role of the SRGP-1 plasma membrane interaction in AJ maturation and ..
  23. Systemic Effects of Bone Marrow-Derived MSCs on Vascular Stability
    Shibani Pati; Fiscal Year: 2012
    ..data suggests that MSCs in contact with endothelial cells promote endothelial stability by enhancing adherens junctions and tight junctions, which results in a net decrease in EC proliferation, angiogenesis and permeability in ..
  24. PI Signaling Role in Epithelial/Mesenchymal Transition
    Richard A Anderson; Fiscal Year: 2013
    ..a phosphoinositide signaling pathway that regulates E-cadherin trafficking, degradation and assembly into adherens junctions in epithelial cells. The same pathway stimulates the activity of ?-catenin transcription...
  25. The Role of Afadin in Coordinating Cell Adhesion Molecules during Synaptogenesis
    GERARD MJ BEAUDOIN; Fiscal Year: 2010
    ..Junctions analogous to adherens junctions are formed during synaptogenesis...
  26. Mechanisms of PMN and Endothelial-Mediated Lung Inflammation and Injury
    Asrar B Malik; Fiscal Year: 2013
    ..Y. Zhao, P.I. will address the role of the Forkhead transcription factor FoxM1 in the repair of endothelial adherens junctions and in the regeneration of the endothelial monolayer after lung vascular injury...
  27. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2012
    The assembly of cells into tissues depends upon formation of intercellular junctions. In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous ..
  28. Vascular Sphingosine Kinase Signaling in Cerebral Ischemic Tolerance
    BRADLEY KENT WACKER; Fiscal Year: 2010
    ..junction proteins PECAM-1 and VE-cadherin to determine if SphK maintenance of the BBB is mediated through adherens junctions. Aim 2: To elucidate the relationship between SphK2, and HIF-1 and HIF-2 during the induction of an Ischemic ..
  29. The Role of the Vasculature in the Pathogenesis of Arthritis
    DEAN YAW LI; Fiscal Year: 2013
    ..MYD88 binds to ARNO, an ARF-GEF that activates the small GTPase ARF6. Active ARF6 disrupts adherens junctions by reducing the levels of cell surface VE-cadherin, which leads to vascular destabilization and increased ..
  30. Calcium Dependent Signaling in Airway Epithelial Cells
    Alice S Prince; Fiscal Year: 2013
    ..across the tight junctions of the epithelial barrier, several membrane spanning proteins of the tight and adherens junctions must be modified...
  31. Role Of p120 Catenin In Sepsis-Induced Lung Injury
    Guochang Hu; Fiscal Year: 2013
    ..p120-catenin, a component of adherens junctions in endothelial cells and other polarized adherent cells, has recently been implicated in the intrinsic ..
  32. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2010
    ..of catenin proteins related to beta-catenin that also bind to E-cadherin and stabilizes E-cadherin at adherens junctions. As a result, expression of E-cadherin and p120ctn appear to be coordinately regulated in many cell lines ..
  33. Role of Cilia/IFT in Skin and Hair
    Bradley K Yoder; Fiscal Year: 2012
    ..in the epidermis alters Wnt signaling by disrupting the formation of the 2-catenin destruction complex and adherens junctions, thereby disrupting the balance between canonical and non-canonical Wnt responsiveness...
  34. Cellular and Molecular Mechanisms in Periventricular Heterotopia
    Volney L Sheen; Fiscal Year: 2013
    ..binds BIG2 and directs BIG2 localization and BIG2-dependent ARF activation, and 3) whether loss of Napa or ARFGEF2 function in neural progenitors alters apical and/or basal adherens junctions leading to PH formation.
  35. Beta-catenin biology in regeneration of uterine smooth muscle
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ..Additionally, 2-catenin plays an essential role in linking adherens junctions with the actin cytoskeleton...
  36. Sphingolipid Signaling in Endothelial Function
    Menq Jer Lee; Fiscal Year: 2012
    ..that S1P1, a Gi-coupled GPCR, regulates endothelial cytoskeletal architectures, chemotaxis, formation of adherens junctions (AJs) and tight junctions (TJs), as well as morphogenic and angiogenic responses...
  37. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2012
    ..In other studies, the role of cell-cell adherens junctions in cell clustering and cell migration will be assessed...
  38. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
    ..Cell contacts provide structural tissue support (mechanical junctions: adherens junctions;desmosomes) and allow fast impulse propagation and the synchronous contraction of the heart muscle (..
  39. Regulation and Function of PTP-PEST in colon carcinoma
    SARITA KANDULA SASTRY; Fiscal Year: 2012
    ..kinase signaling at cell-cell contacts contributes to the invasion of colon carcinomas through disruption of adherens junctions. Cadherin engagement promotes cell-cell adhesion and contact inhibition of cell motility through regulation ..
  40. EPITHELIAL MORPHOGENESIS IN DEVELOPMENT AND DISEASE
    GREGORY LONGMORE; Fiscal Year: 2013
    ..Unfortunately, epithelial cells are also the most common cell type implicated in cancer. Cadherin-based adherens junctions (AJ) mediate initial epithelial cell-cell adhesion allowing cells to assemble into polarized multicellular ..
  41. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2013
    ..of catenin proteins related to beta-catenin that also bind to E-cadherin and stabilizes E-cadherin at adherens junctions. As a result, expression of E-cadherin and p120ctn appear to be coordinately regulated in many cell lines ..
  42. Cell-cell adhesion and signal transduction
    Valeri Vasioukhin; Fiscal Year: 2012
    ..While cells use different types of cell-cell adhesion structures, the Adherens Junctions appear to be often perturbed in human cancers...
  43. THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITY
    Asrar B Malik; Fiscal Year: 2012
    ..The endothelial adherens junctions (AJs) consisting of VE-cadherin and its associated catenins is a major determinant of fluid and plasma ..
  44. Actin Assembly at cadherin dependent adherens junctions
    William M Brieher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adherens junctions are specialized sites of strong cell-cell adhesion built around cadherin adhesion molecules that organize an actin cytoskeleton to mechanically couple adjacent cells...
  45. Function of Mesendoderm in Closure of the Anterior Neural Tube
    Jennifer O Liang; Fiscal Year: 2012
    ..Our objectives are to: (1) identify the sequential biochemical changes that establish adherens junctions, tight junctions, and asymmetric protein localization in the developing neuroepithelium, (2) define which of ..
  46. Targeting cytokine-mediated pathologies for neuroprotection in treatment of AMD
    Kirill Ostanin; Fiscal Year: 2013
    ..validated as a promising drug target that, by virtue of its central role in destabilizig interendothelial adherens junctions, is prominently involved in promoting cytokine-mediated vascular hyperpermeability, angiogenesis and immune ..
  47. Heg-CCM Signaling in Cardiovascular Development and Disease
    Mark L Kahn; Fiscal Year: 2013
    ..CCM2 knockdown blocks endothelial cord formation ex vivo and endothelial adherens junctions are abnormally shortened in the dilated chambers of fish lacking Heg or CCM2...
  48. INTEGRIN SIGNALING DURING BREAST TUMORIGENESIS
    Filippo G Giancotti; Fiscal Year: 2013
    ..The signaling pathways through which hyperactivation of Rac causes disassembly of adherens junctions will be studied by using biochemical analysis, silencing, and imaging methods;3) To Study the Molecular ..
  49. Function of Cerebral Cavernous Malformation Proteins
    Gary L Johnson; Fiscal Year: 2013
    ..E3 ubiquitination of RhoA and Rap1 resulting in dysregulated control of the actin cytoskeleton and adherens junctions in ECs...
  50. Reorganization of the Actin Cytoskeleton in Airway Smooth Muscle
    Dale D Tang; Fiscal Year: 2013
    ..In Aim 3, the formation and/or assembly of adherens junctions in airway smooth muscle upon contractile stimulation will be assessed...
  51. Mechanisms of cell contact inhibition and their dysregulation in cancer.
    JOSEPH KISSIL; Fiscal Year: 2013
    ..Angiomotins, members of the Motin protein family, as Merlin-interacting proteins that localize to tight and adherens junctions. Importantly, we determined that Merlin's ability to regulate mitogenic signaling is mediated through ..
  52. Apoptotic Signaling Induces Hyperpermeability Following Hemorrhagic Shock
    Ed W Childs; Fiscal Year: 2010
    ..The research plan focuses on the regulation of endothelial cell-cell adherens junctions to prevent microvascular hyperpermeability following hemorrhagic shock...
  53. Maintenance of Stem Cell Fates in Drosophila
    Edwin L Ferguson; Fiscal Year: 2010
    ..The GSCs are anchored to the cap cells by adherens junctions. Moreover, Bone Morphogenetic Protein (BMP) family members act as intercellular signals necessary for GSC ..
  54. Regulation of endothelial adhesion by VE-cadherin endocytosis
    BENJAMIN ANDREW NANES; Fiscal Year: 2013
    ..in the regulation of vascular endothelial cadherin (VE-cadherin), the main adhesion molecule in endothelial adherens junctions. Despite the importance of VE-cadherin to vessel development, angiogenesis, and inflammation, relatively ..
  55. Regulation of epithelial contact inhibition by Rac effector proteins
    MIRJAM M ZEGERS; Fiscal Year: 2010
    ..Epithelial cell-cell contacts are mainly formed by E-cadherin-based adherens junctions, which function as a focal point of many signaling pathways regulating various cellular behaviors, including ..
  56. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea I McClatchey; Fiscal Year: 2013
    ..the initial funding of this proposal, we discovered that Merlin coordinates the establishment of stable adherens junctions (AJs) between cells with the inhibition of Epidermal Growth Factor Receptor (EGFR) internalization and ..
  57. ZO-1 &Cytoplasmic Scaffolding of the Tight Junction
    ALAN SCOTT FANNING; Fiscal Year: 2012
    ..for TJ assembly and are directly involved in linking early spot-like cadherin contacts to continuous adherens junctions and subsequent recruitment of TJ proteins into barrier strands...
  58. Mechanisms Directing Adherens Junctions and Actin Network Interactions
    Tina Izard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The formation and stabilization of cell-cell adhesion complexes (adherens junctions) is essential for metazoan development, organogenesis and tissue homeostasis, and is also necessary for some ..
  59. Pathogen-host Interactions that Remodel the Cytoskeleton
    Tina Izard; Fiscal Year: 2010
    ..as talin, which binds to integrin receptors in focal adhesions, or to a- actinin, which plays key roles in adherens junctions. Our recent studies have shown that talin and a-actinin activate vinculin by disrupting the intramolecular ..
  60. Signaling of Endothelial Permeability and Lung Vascular Injury
    Asrar B Malik; Fiscal Year: 2013
    ..and novel relationship between endothelial caveolin-1, the structural and signaling protein of caveolae, and adherens junctions (AJs), the structures known to regulate permeability of the junctions based on the postulate of a cross-talk ..
  61. Cytokine induction of Claudin-1 in epicardial border zone of ischemic heart
    Heather S Duffy; Fiscal Year: 2010
    In normal myocardium multiple cell-cell junctions allow for close membrane apposition (via adherens junctions) that are very stable (via desmosomes) and support the formation of electrical junctions (gap junctions)...
  62. Role of TGF beta receptor III localization in breast cancer progression
    ALISON MEYER; Fiscal Year: 2013
    ..As components of adherens junctions have been demonstrated to interact with other TGF- receptors, I hypothesize that localization of T RIII at ..
  63. Xenobiotics and Breast Epithelial Cell-ECM Signaling
    Raymond Novak; Fiscal Year: 2005
    ..Other types of structures that link cells to each other or to the ECM include adherens junctions and desmosomes...
  64. Communication Between Laminin 5 and Gap Junctions
    William Carter; Fiscal Year: 2005
    ..Cell-cell interactions are mediated by at least three types of intercellular junctions: adherens junctions (AJs), desmosomes and gap junctions (GJs)...
  65. ADHESION MOLECULES AND EPIDERMAL STRATIFICATION
    ROBERT LAVKER; Fiscal Year: 2001
    ..Although desmosomes apparently provide the mechanical strength in adhesion, adherens junctions provide the specificity, and are essential for the proper formation of desmosomes as well...
  66. MECHANISMS OF VASCULAR BARRIER REGULATION
    Kane Schaphorst; Fiscal Year: 2001
    ..interactions between the endothelial cytoskeleton and tethering mechanisms involving focal adhesions and adherens junctions. SA #1 Will examine the regulation of focal adhesion plaque proteins in MLCK-independent barrier dysfunction...
  67. Determinants of Phenotype in Retinal Pigment Epithelium
    Janice Burke; Fiscal Year: 2007
    ..E-cadherin accumulation in RPE cells is suppressed by proteolytic degradation during the interval when adherens junctions are forming...
  68. Regulation of Proteins in the Apical Junctional Complex by Citrobacter rodentium
    Jan Michael Klapproth; Fiscal Year: 2009
    ..addition, we provide evidence that the protease activity leads to dissociation of [unreadable]-catenin from adherens junctions by activating RhoA...
  69. CYTOCHALASIN AND PROTEINS THAT AFFECT ENDS OF F-ACTIN
    Shin Lin; Fiscal Year: 1999
    ..signal transduction: (1) Tensin has been immunolocalized to muscle Z-lines and cell-cell and cell-substrate adherens junctions, locations where actin filament ends are associated with other structures...
  70. DESMOSOMES--STRUCTURE/FUNCTION
    EDWARD O KEEFE; Fiscal Year: 2000
    Two types of epithelial cell-cell junctions, desmosomes and adherens junctions, are important in maintaining the integrity of epithelium...