cardiac myocytes

Summary

Summary: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).

Top Publications

  1. ncbi Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
    Wilhelm Roell
    Institute of Physiology I, Life and Brain Center, University of Bonn, Bonn 53105, Germany
    Nature 450:819-24. 2007
  2. ncbi Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    Michael A Laflamme
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Nat Biotechnol 25:1015-24. 2007
  3. pmc Cytoplasmic cAMP concentrations in intact cardiac myocytes
    Radu V Iancu
    Dept of Physiology and Biophysics, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Cell Physiol 295:C414-22. 2008
  4. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  5. ncbi Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    Lei Yang
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 453:524-8. 2008
  6. ncbi Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    Alessandra Moretti
    Massachusetts General Hospital Cardiovascular Research Center, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 127:1151-65. 2006
  7. pmc Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    Shweta Rane
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Division of Nephrology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Circ Res 104:879-86. 2009
  8. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
  9. ncbi Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens
    Rachel Ruckdeschel Smith
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:896-908. 2007
  10. ncbi Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
    Abeel A Mangi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115 USA
    Nat Med 9:1195-201. 2003

Detail Information

Publications352 found, 100 shown here

  1. ncbi Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
    Wilhelm Roell
    Institute of Physiology I, Life and Brain Center, University of Bonn, Bonn 53105, Germany
    Nature 450:819-24. 2007
    ..Thus, engraftment of Cx43-expressing myocytes has the potential to reduce life-threatening post-infarct arrhythmias through the augmentation of intercellular coupling, suggesting autologous strategies for cardiac cell-based therapy...
  2. ncbi Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    Michael A Laflamme
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Nat Biotechnol 25:1015-24. 2007
    ..The ability of hES cell-derived cardiomyocytes to partially remuscularize myocardial infarcts and attenuate heart failure encourages their study under conditions that closely match human disease...
  3. pmc Cytoplasmic cAMP concentrations in intact cardiac myocytes
    Radu V Iancu
    Dept of Physiology and Biophysics, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Cell Physiol 295:C414-22. 2008
    In cardiac myocytes there is evidence that activation of some receptors can regulate protein kinase A (PKA)-dependent responses by stimulating cAMP production that is limited to discrete intracellular domains...
  4. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  5. ncbi Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    Lei Yang
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 453:524-8. 2008
    ..Together, these findings identify a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development...
  6. ncbi Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    Alessandra Moretti
    Massachusetts General Hospital Cardiovascular Research Center, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 127:1151-65. 2006
    ....
  7. pmc Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    Shweta Rane
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Division of Nephrology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Circ Res 104:879-86. 2009
    ..We report here that miR-199a is acutely downregulated in cardiac myocytes on a decline in oxygen tension...
  8. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
    ..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
  9. ncbi Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens
    Rachel Ruckdeschel Smith
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:896-908. 2007
    ..Ex vivo expansion of resident cardiac stem cells, followed by delivery to the heart, may favor regeneration and functional improvement...
  10. ncbi Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
    Abeel A Mangi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115 USA
    Nat Med 9:1195-201. 2003
    ..Thus, mesenchymal stem cells genetically enhanced with Akt1 can repair infarcted myocardium, prevent remodeling and nearly normalize cardiac performance...
  11. ncbi Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    Christine Mummery
    Hubrecht Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 107:2733-40. 2003
    ..Here, we induced cardiomyocyte differentiation of hES cells by a novel method and compared their electrophysiological properties and coupling with those of primary human fetal cardiomyocytes...
  12. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    ..These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration...
  13. ncbi Isolation and expansion of adult cardiac stem cells from human and murine heart
    Elisa Messina
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Circ Res 95:911-21. 2004
    b>Cardiac myocytes have been traditionally regarded as terminally differentiated cells that adapt to increased work and compensate for disease exclusively through hypertrophy...
  14. ncbi Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
    Ildiko Bock-Marquette
    Department of Pediatrics, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 432:466-72. 2004
    ..These findings suggest that thymosin beta4 promotes cardiomyocyte migration, survival and repair and the pathway it regulates may be a new therapeutic target in the setting of acute myocardial damage...
  15. ncbi Generation of functional murine cardiac myocytes from induced pluripotent stem cells
    Christina Mauritz
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 118:507-17. 2008
    ..The aim of this study was to characterize the cardiac differentiation potential of a murine iPS cell clone in comparison to a well-established murine ES cell line...
  16. ncbi Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages
    Steven J Kattman
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 11:723-32. 2006
    ..Isolation and characterization of this previously unidentified population suggests that the mammalian cardiovascular system develops from multipotential progenitors...
  17. ncbi Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Nature 425:968-73. 2003
    ..These observations provide the first in vivo evidence for cell fusion of BMDCs with neurons and cardiomyocytes, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types...
  18. ncbi Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
    Tomosaburo Takahashi
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 107:1912-6. 2003
    ..In appropriate culture conditions, ES cells can differentiate into specialized cells, including cardiac myocytes, but the efficiency is typically low and the process is incompletely understood.
  19. ncbi Calcium cycling and signaling in cardiac myocytes
    Donald M Bers
    Department of Physiology and Cardiovascular Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Annu Rev Physiol 70:23-49. 2008
    ..This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophysiology (including action potentials and arrhythmias), excitation-contraction ..
  20. ncbi Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes
    Nobuhiro Suematsu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 107:1418-23. 2003
    ..However, the cause and consequences of this agonist-mediated ROS production in cardiac myocytes have not been well defined...
  21. pmc Adiponectin-mediated modulation of hypertrophic signals in the heart
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, Massachusetts 02118, USA
    Nat Med 10:1384-9. 2004
    ..In cultures of cardiac myocytes, adiponectin activated AMPK and inhibited agonist-stimulated hypertrophy and ERK activation...
  22. ncbi Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes
    Jin Song Bian
    Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    J Pharmacol Exp Ther 316:670-8. 2006
    ..cell viability and the amplitude of electrically induced calcium transients after ischemia/reperfusion in cardiac myocytes. Both IP and SP also significantly attenuated the decreased H(2)S production during ischemia...
  23. ncbi Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
    Sean M Wu
    Division of Hematology Oncology, Children s Hospital, Boston, MA 02115, USA
    Cell 127:1137-50. 2006
    ..5(+) cells from mouse embryos and demonstrated their capacity for bipotential differentiation in vivo. Taken together, these results support the existence of a common precursor for cardiovascular lineages in the mammalian heart...
  24. pmc MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101 1709, USA
    J Mol Cell Cardiol 47:5-14. 2009
    ..Currently, the effects of ROS on miRNA expression and the roles of miRNAs in ROS-mediated injury on cardiac myocytes are uncertain...
  25. ncbi Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    Kevin Bersell
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Cell 138:257-70. 2009
    ..Undifferentiated progenitor cells did not contribute to NRG1-induced cardiomyocyte proliferation. Thus, increasing the activity of the NRG1/ErbB4 signaling pathway may provide a molecular strategy to promote myocardial regeneration...
  26. pmc Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
    Maria Mirotsou
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:1643-8. 2007
    ..These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease...
  27. ncbi Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
    Jiajia Fu
    Department of Pharmacology and Toxicology, Sun Yat Sen University, Guangzhou, 510080, PR China
    Eur J Pharmacol 568:213-21. 2007
    ..Taken together, these data for the first time provide convincing evidence that tan protects cardiac myocytes against oxidative stress-induced apoptosis...
  28. pmc Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes
    Priscila Y Sato
    Center for Arrhythmia Research, University of Michigan, 5025 Venture Dr, Ann Arbor, MI 48108, USA
    Circ Res 105:523-6. 2009
    ..Recent data show that it interacts with other molecules of the intercalated disc. Separate studies show preferential localization of the voltage-gated sodium channel (Na(V)1.5) to this region...
  29. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    ..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
  30. pmc Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
    Patrick C H Hsieh
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Med 13:970-4. 2007
    ..5% in areas bordering a myocardial infarction, 76.6% in areas away from a myocardial infarction, and 75.7% in hearts subjected to pressure overload, indicating that stem cells or precursor cells had refreshed the cardiomyocytes...
  31. pmc Human cardiac stem cells
    Claudia Bearzi
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 104:14068-73. 2007
    ..Thus, hCSCs can be isolated and expanded in vitro for subsequent autologous regeneration of dead myocardium in patients affected by heart failure of ischemic and nonischemic origin...
  32. pmc Role of glycogen synthase kinase-3beta in cardioprotection
    Magdalena Juhaszova
    Laboratory of Cardiovascular Science, Gerontology Research Center, Box 13, National Institute on Aging, NIH, Baltimore, Maryland 21224 6825, USA
    Circ Res 104:1240-52. 2009
    ....
  33. pmc Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes
    Tetsuro Ago
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Newark, NJ 07103, USA
    Circ Res 106:1253-64. 2010
    ..NADPH oxidases are a major source of superoxide (O(2)(-)) in the cardiovascular system. The function of Nox4, a member of the Nox family of NADPH oxidases, in the heart is poorly understood...
  34. pmc CXCR4 modulates contractility in adult cardiac myocytes
    Robert T Pyo
    Zena and Michael A Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Mol Cell Cardiol 41:834-44. 2006
    ..Murine papillary muscles and adult rat cardiac myocytes treated with CXCL12, the only identified ligand of CXCR4, demonstrate blunted inotropic responses to ..
  35. ncbi Hypertrophy of the heart: a new therapeutic target?
    Norbert Frey
    Department of Cardiology, University of Heidelberg N F, H A K, Heidelberg, Germany
    Circulation 109:1580-9. 2004
    ..We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy...
  36. ncbi Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes
    Liliana R V Castro
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Inserm U769, Chatenay Malabry Cedex, France
    Circ Res 107:1232-40. 2010
    ..We have shown recently that particulate (pGC) and soluble guanylyl (sGC) cyclases synthesize cGMP in different compartments in adult rat ventricular myocytes (ARVMs)...
  37. ncbi Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization
    Jia Qiang He
    Department of Anatomy, University of Wisconsin, Madison, Wis 53792 3248, USA
    Circ Res 93:32-9. 2003
    ..Thus, hES provide a renewable source of distinct types of human cardiac myocytes for basic research, pharmacological testing, and potentially therapeutic applications.
  38. ncbi Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function
    Steven M White
    Dept of Biochemistry and Molecular Biology, Louisiana State Univ Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Am J Physiol Heart Circ Physiol 286:H823-9. 2004
    ....
  39. pmc Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages
    Katja Schenke-Layland
    Department of Medicine and Physiology, Cardiovascular Research Laboratory, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1760, USA
    Stem Cells 26:1537-46. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  40. pmc Paracrine mechanisms in adult stem cell signaling and therapy
    Massimiliano Gnecchi
    Mandel Center for Hypertension Research, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 103:1204-19. 2008
    ..Furthermore, cardiac remodeling, contractility, and metabolism may also be influenced in a paracrine fashion. This article reviews the potential paracrine mechanisms involved in adult stem cell signaling and therapy...
  41. ncbi Isolation and culture of adult mouse cardiac myocytes
    Manoj C Rodrigo
    Department of Medicine, The University of South Dakota, Sioux Falls, USA
    Methods Mol Biol 357:271-96. 2007
    b>Cardiac myocytes are activated by hormonal and mechanical signals and respond in a variety of ways, from altering contractile function to inducing cardio-protection and growth responses...
  42. ncbi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  43. ncbi CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation
    Otmar Pfister
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 97:52-61. 2005
    ....
  44. ncbi SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction
    Ming Zhang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    FASEB J 21:3197-207. 2007
    ..Whether the improved cardiac function results from regeneration of cardiac myocytes, modulation of remodeling, or preservation of injured tissue through paracrine mechanisms is actively debated...
  45. ncbi Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
    Ralph R Alcendor
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Circ Res 95:971-80. 2004
    ..We examined whether or not the mammalian ortholog Sir2 affects growth and death of cardiac myocytes. Cardiac myocytes express Sir2alpha predominantly in the nucleus...
  46. ncbi PKC-alpha regulates cardiac contractility and propensity toward heart failure
    Julian C Braz
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Nat Med 10:248-54. 2004
    ..Adenoviral gene transfer of dominant-negative or wild-type PKC-alpha into cardiac myocytes enhances or reduces contractility, respectively...
  47. ncbi G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
    Mutsuo Harada
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nat Med 11:305-11. 2005
    ..These results suggest that G-CSF promotes survival of cardiac myocytes and prevents left ventricular remodeling after myocardial infarction through the functional communication ..
  48. pmc Activation of Notch-mediated protective signaling in the myocardium
    Natalie A Gude
    San Diego State University Heart Institute, Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Circ Res 102:1025-35. 2008
    ..This mutually supportive crosstalk suggests a positive survival feedback mechanism between Notch and Akt signaling in adult myocardium following injury...
  49. ncbi Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    Charles E Murry
    Department of Pathology, Box 357470, Room D 514 HSB, University of Washington, Seattle, Washington 98195, USA
    Nature 428:664-8. 2004
    ..These results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair...
  50. ncbi Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    Anne Hamacher-Brady
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:29776-87. 2006
    b>Cardiac myocytes undergo programmed cell death as a result of ischemia/reperfusion (I/R). One feature of I/R injury is the increased presence of autophagosomes...
  51. pmc Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function
    Marcello Rota
    Department of Anesthesia and Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:107-16. 2008
    ..These forms of treatments could be repeated over time to reduce progressively tissue scarring and expand the working myocardium...
  52. ncbi Calcium homeostasis and signaling in yeast cells and cardiac myocytes
    Jiangjun Cui
    Department of Computer Science, National University of Singapore, Singapore, Singapore
    FEMS Yeast Res 9:1137-47. 2009
    ..detailed comparison between the calcium homeostasis/signaling networks in yeast cells and those in mammalian cardiac myocytes. This comparison covers not only the components, structure and function of the networks but also includes ..
  53. ncbi Localised Ca channel phosphorylation modulates the distribution of L-type Ca current in cardiac myocytes
    Anabelle Chase
    Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Mol Cell Cardiol 49:121-31. 2010
    ..This may have important implications in heart disease, in which changes of phosphorylation and t-tubule density have been reported...
  54. ncbi Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling
    Mohamed Nemir
    Ludwig Institute for Cancer Research, Lausanne Branch, University Lausanne, Epalinges VA 1066, Switzerland
    Circ Res 98:1471-8. 2006
    ..These findings should help to optimize the production of specific cell types via modulation of the Notch pathways and, in particular, to improve the production of embryonic stem cell-derived cardiomyocytes...
  55. ncbi Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes
    Huichao Sun
    Heart Centre, Children s Hospital of Chongqing Medical University, Chongqing, PR China
    Life Sci 87:707-14. 2010
    ..In this study, we investigated the relationship between histone hypo-acetylation and the expression of cardiac-specific genes to explore the underlying mechanisms...
  56. pmc Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart
    Alexander R Lyon
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 106:6854-9. 2009
    ..This study confirms the loss of T-tubules as part of the phenotypic change in the failing human myocyte, but it also shows that this is part of a wider spectrum of alterations in surface morphology...
  57. ncbi Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells
    Genta Narazaki
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Circulation 118:498-506. 2008
    ..However, detailed differentiation properties and the directional differentiation system of iPS cells have not been demonstrated...
  58. pmc Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes
    Casey D Wright
    Cardiovascular Research Center, Sanford Research USD, Sioux Falls, SD 57105, USA
    Circ Res 103:992-1000. 2008
    ..alpha1A-adrenergic receptor-extracellular signal-regulated kinase) survival signaling pathway in adult cardiac myocytes. Here, we investigated localization of alpha1-AR subtypes (alpha1A and alpha1B) and how their localization ..
  59. ncbi GATA-4 promotes the differentiation of P19 cells into cardiac myocytes
    De Liang Hu
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China
    Int J Mol Med 26:365-72. 2010
    ..The overexpression of GATA-4 enhances the differentiation of P19 cells into cardiac myocytes, whereas its down-regulation suppresses this trend.
  60. ncbi Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes
    C N White
    Department of Cardiology, Royal North Shore Hospital, Sydney, Australia
    Am J Physiol Cell Physiol 294:C572-8. 2008
    ..To image NO, we loaded isolated rabbit cardiac myocytes with 4,5-diaminofluorescein-2 diacetate (DAF-2 DA) and measured fluorescence with confocal microscopy...
  61. pmc p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
    Felix B Engel
    Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:1175-87. 2005
    ..Our findings establish p38 as a key negative regulator of cardiomyocyte proliferation and indicate that adult cardiomyocytes can divide...
  62. ncbi Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes
    Yuan Yan
    Institute of Molecular Medicine, National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China
    Cardiovasc Res 77:432-41. 2008
    ..In cardiac myocytes, arrayed RyRs or Ca(2+) release units are packed in the close proximity of mitochondria, the primary source ..
  63. pmc Stem cell niches in the adult mouse heart
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 103:9226-31. 2006
    ..Thus, CSCs regulate myocyte turnover that is heterogeneous across the heart, faster at the apex and atria, and slower at the base-midregion of the ventricle...
  64. pmc Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart
    Juliano L Sartoretto
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 297:H1697-710. 2009
    ..significant increase in basal VASP expression, along with an increase in VASP phosphorylation, compared with cardiac myocytes isolated from sham-operated mice...
  65. ncbi Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor
    E Ann Tallant
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 289:H1560-6. 2005
    ..ANG type 1-7 (AT(1-7)) receptor antagonist, blocked the ANG-(1-7)-mediated reduction in protein synthesis in cardiac myocytes, whereas the AT(1) and AT(2) angiotensin peptide receptors were ineffective...
  66. ncbi Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin
    Giedrius Gaudesius
    Department of Physiology, University of Bern, Switzerland
    Circ Res 93:421-8. 2003
    ..This synchronization is accompanied by extremely large local conduction delays, which might contribute to the generation of arrhythmias in fibrotic hearts...
  67. ncbi Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury
    Denise Hilfiker-Kleiner
    Department of Cardiology, Medical School Hannover, Germany
    Circ Res 95:187-95. 2004
    ....
  68. pmc MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes
    Hitoo Nishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 285:4920-30. 2010
    ..The present results suggest that miR-15b may decrease mitochondrial integrity by targeting Arl2 in the heart...
  69. ncbi Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure
    Xun Ai
    Department of Medicine, University of Illinois at Chicago, IL 60612, USA
    Circ Res 97:1314-22. 2005
    ..Our results suggest that CaMKII-dependent phosphorylation of RyR2 is involved in enhanced SR diastolic Ca leak and reduced SR Ca load in HF, and may thus contribute to arrhythmias and contractile dysfunction in HF...
  70. pmc TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy
    Naoya Onohara
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka
    EMBO J 25:5305-16. 2006
    ..production of diacylglycerol (DAG) but not IP(3) is essential for Ang II-induced NFAT activation in rat cardiac myocytes. NFAT activation and hypertrophic responses by Ang II stimulation required the enhanced frequency of Ca(2+) ..
  71. ncbi Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes
    Abdelkarim Sabri
    Department of Physiology and Biophysics, University of Alabama Birmingham, Birmingham, AL 35294, USA
    Antioxid Redox Signal 5:731-40. 2003
    ..This review will focus on the mechanisms by which ROS/RNS modulate cardiac myocyte growth and apoptosis induced by neurohormones and cytokines, and will discuss evidence for a role in the pathophysiology of heart failure...
  72. pmc Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
    Stefan Wagner
    Department of Cardiology and Pneumology, Georg August University Gottingen, Gottingen, Germany
    J Clin Invest 116:3127-38. 2006
    ..In mice, enhanced CaMKIIdelta(C) activity predisposed to VT. Thus, CaMKII-dependent regulation of Na(+) channel function may contribute to arrhythmogenesis in HF...
  73. ncbi Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes
    Donna J Thuerauf
    San Diego State University Heart Institute and the Department of Biology, San Diego State University, Calif 92182, USA
    Circ Res 99:275-82. 2006
    ..Moreover, mouse hearts subjected to in vivo myocardial infarction exhibited increased GRP78 expression in cardiac myocytes near the infarct, but not in healthy cells distal to the infarct...
  74. ncbi Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes
    Ralica Petrova
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8640, Japan
    J Mol Cell Cardiol 34:1425-31. 2002
    ..transgenic mice that overexpressed human RAGE in the heart and analyzed the Ca(2+) transients in cultivated cardiac myocytes (CM) from the RAGE-transgenic and non-transgenic control fetuses...
  75. pmc CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes
    Scott M MacDonnell
    Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Circ Res 105:316-25. 2009
    ..Cytoplasmic CaMKII regulates Ca(2+) handling proteins but whether or not it is directly involved in hypertrophic and survival signaling is not known...
  76. ncbi The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
    Kunhua Song
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 125:453-66. 2006
    Postnatal cardiac myocytes respond to diverse signals by hypertrophic growth and activation of a fetal gene program...
  77. pmc Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 102:3766-71. 2005
    ..The results establish CSCs as candidates for cardiac regeneration and support an approach in which the heart's own stem cells could be collected, expanded, and stored for subsequent therapeutic repair...
  78. pmc Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium
    Eugen Kolossov
    Axiogenesis AG, 50931 Cologne, Germany
    J Exp Med 203:2315-27. 2006
    ..Hence, our results demonstrate that ES-based cell therapy is a promising approach for the treatment of impaired myocardial function and provides better results than BM-derived cells...
  79. pmc Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes
    David Baddeley
    Department of Physiology, University of Auckland, Auckland 1142, New Zealand
    Proc Natl Acad Sci U S A 106:22275-80. 2009
    ..We suggest that calcium sparks may be the result of the concerted activation of several RyR clusters forming a functional "supercluster" whose gating is controlled by both cytosolic and sarcoplasmic reticulum luminal calcium levels...
  80. ncbi Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy
    Zhao Yang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Res 99:646-55. 2006
    ..These data suggest DSP expression in cardiomyocytes is crucial for maintaining cardiac tissue integrity, and DSP abnormalities result in ARVD/C by cardiomyocyte death, changes in lipid metabolism, and defects in cardiac development...
  81. pmc Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles
    Sylvain Brunet
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110 1093, USA
    J Physiol 559:103-20. 2004
    ....
  82. ncbi Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes?
    Masamichi Koyanagi
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Germany
    Circ Res 96:1039-41. 2005
    ..Thus, the present study shows a novel type of cell-to-cell communication between progenitor cells and CM in vitro, which may contribute to the acquisition of a cardiomyogenic phenotype independent of permanent cellular or nuclear fusion...
  83. pmc Evidence for cardiomyocyte renewal in humans
    Olaf Bergmann
    Department of Cell and Molecular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Science 324:98-102. 2009
    ..The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies...
  84. pmc Death begets failure in the heart
    Roger S Y Foo
    Department of Medicine, Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 115:565-71. 2005
    ..Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications...
  85. ncbi The Rac and Rho hall of fame: a decade of hypertrophic signaling hits
    Joan Heller Brown
    Department of Pharmacology, University of California, San Diego, USA
    Circ Res 98:730-42. 2006
    ..In this review, we assess the evolution of knowledge related to Rac1 and RhoA in the context of hypertrophy and heart failure and highlight the direction that future exploration will lead...
  86. ncbi High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes
    Vivek P Singh
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 293:H939-48. 2007
    ..Significantly, NRVM synthesized and retained ANG II intracellularly, which redistributed to the nucleus under high-glucose conditions, suggesting a role for an intracrine mechanism in diabetic conditions...
  87. ncbi Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
    Yi Lisa Lyu
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    Cancer Res 67:8839-46. 2007
    ....
  88. ncbi Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    Izhak Kehat
    The Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium, Department of Biophysics and Physiology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa, Israel
    Nat Biotechnol 22:1282-9. 2004
    ..These results demonstrate the potential of hES-cell cardiomyocytes to act as a rate-responsive biological pacemaker and for future myocardial regeneration strategies...
  89. ncbi WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1
    Zhiqiang Liu
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, 38 Xue Yuan Road, Hai Dian District, Beijing, 100191, China
    Biochim Biophys Acta 1793:300-11. 2009
    ..Our data suggest that WNT signaling pathway plays important roles in the regulation of Hdac1 during the early stage of cardiomyocyte differentiation and that the downregulation of Hdac1 promotes cardiac differentiation...
  90. pmc Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes
    Tatyana N Andrienko
    Department of Pharmacology, University of California Davis, Davis, CA 95616 8636, USA
    J Mol Cell Cardiol 46:1027-36. 2009
    ..Thus small phasic [Ca(2+)](mito) transients and gradually integrating [Ca(2+)](mito) signals occur during repeating [Ca(2+)](i) transients...
  91. pmc Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status
    Miguel A Aon
    Institute of Molecular Cardiobiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 282:21889-900. 2007
    ..The results indicate that GSH/GSSG redox status governs the sequential opening of mitochondrial ion channels (IMAC before PTP) triggered by thiol oxidation in cardiomyocytes...
  92. pmc RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes
    Mickael Derangeon
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, F 86022 Poitiers, France
    J Biol Chem 283:30754-65. 2008
    ..The inhibition of Rho downstream kinase effectors had no effect on GJIC. The present results provide further insight into the gating and regulation of junctional channels and identify a new downstream target for the small G-protein RhoA...
  93. ncbi Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes
    Mélanie Métrich
    INSERM, U769, Signalisation et Physiopathologie Cardiaque, Chatenay Malabry, France
    Pharmacol Rep 61:146-53. 2009
    ..This review will focus on recent pharmacological and biochemical studies aiming at understanding the role of Epac in cardiomyocyte signaling and hypertrophy...
  94. pmc Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death
    Dmitry Terentyev
    Department of Physiology, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210 1252, USA
    Biophys J 95:2037-48. 2008
    ..Furthermore, two CPVT-inducing CASQ2 mutations, which cause mechanistically different defects in CASQ2 and RyR2 function, lead to increased diastolic SR Ca release events and exhibit a similar CPVT disease phenotype...
  95. ncbi Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers
    Tian Xue
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Circulation 111:11-20. 2005
    ..Although CMs can be derived from hESCs ex vivo, it remains uncertain whether a functional syncytium can be formed between donor and recipient cells after engraftment...
  96. pmc Notch1 regulates the fate of cardiac progenitor cells
    Alessandro Boni
    Department of Anesthesia and Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:15529-34. 2008
    ..In conclusion, Notch1 may have critical implications in the control of heart homeostasis and its adaptation to pathologic states...
  97. ncbi Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium
    Sunshine Lahmers
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Wash 99164, USA
    Circ Res 94:505-13. 2004
    ..Changes in titin expression are likely to impact functional transitions and diastolic filling behavior during development of the heart...
  98. pmc Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents
    Isabelle Deschenes
    Department of Medicine, Division of Cardiology, Johns Hopkins University, 720 N Rutland Avenue, Ross 844, Baltimore, MD 21205, USA
    J Mol Cell Cardiol 45:336-46. 2008
    ..current (I(to)) encoded by the Kv4 family of potassium channels, is central to normal repolarization of cardiac myocytes. KChIPs are a group of Ca(2+)-binding accessory subunits that modulate Kv4-encoded currents...
  99. pmc Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase
    H Lal
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, Central Texas Veterans Health Care System, 1901 South 1st Street, Bldg 205, Temple, TX 76504, USA
    J Mol Cell Cardiol 43:137-47. 2007
    ..Both angiotensin II (Ang II) and mechanical stretch activate MAP kinases in cardiac myocytes. In this study, we used a neonatal rat ventricular myocyte (NRVM) model to determine the role of focal-..
  100. pmc Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes
    Chiao Po Hsu
    Cardiovascular Research Institute, UMDNJ Newark, 185 S Orange Ave, MSB G609, Newark, NJ 07103, USA
    Circ Res 105:481-91. 2009
    ..The cellular NAD+ synthesis is regulated by both the de novo and the salvage pathways. Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the salvage pathway...
  101. ncbi Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study
    Hiroaki Nakamura
    Department of Bio Informational Pharmacology, Medical Research Institute, Tokyo, Japan
    Circulation 116:2913-22. 2007
    ..Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardiac repolarization remains undetermined...

Research Grants69

  1. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Diabetic cardiomyopathy may develop because of the dysfunctional accumulation of lipids in cardiac myocytes. Insulin action is dependent on the activation of an intracellular signaling pathway that stimulates the ..
  2. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..Stimulation of 2-adrenergic receptor (2-AR) increases apoptosis in cardiac myocytes in vitro and in vivo...
  3. JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.
    Keith A Webster; Fiscal Year: 2010
    ..We previously described an energy-dependent switch in the function of JNK in cultured cardiac myocytes. The switch occurred when cardiac myocyte ATP level fell by below 50%, a condition that sensitized myocytes ..
  4. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..stressed hearts first undergo hypertrophy, but ultimately fail in part due to apoptotic loss of cardiac myocytes. Importantly, hypertrophy develops in the surviving myocardium after an acute infarct to counterbalance ..
  5. Extracellular ubiquitin: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2010
    ..biochemical strategies, we have identified increased levels of ubiquitin in the conditioned media of adult cardiac myocytes following ?-AR stimulation, a stimulus which induces cardiac myocyte apoptosis in vitro and in vivo...
  6. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..Conversely, overexpression of Cav-3 in cardiac myocytes blocks adrenergic agonist and endothelin-1 induced myocyte hypertrophy...
  7. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..In addition, GRK2 can be found in/on mitochondria in cardiac myocytes through novel protein-protein interaction via the amino-terminus of GRK2...
  8. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..Once cardiac myocytes terminally differentiate they can no longer divide but they retain a remarkable capacity to enlarge...
  9. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..and targeting of cAMP-dependent protein kinase (PKA) by A-kinase anchoring proteins (AKAP) in isolated rat cardiac myocytes and in normal and failing rat heart and assesses the functional implications of disruption of PKA targeting...
  10. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..3 messenger RNA (mRNA), which limits Ito channel expression in humans, is destabilized in cultured cardiac myocytes by stretch and Angiotensin II (AII), a hormone implicated in hypertension and congestive heart failure...
  11. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..S1P is a lysophospholipid produced by mast cells, erythrocytes, platelets, cardiac myocytes, and other cell types in de novo biosynthetic pathways and by metabolism of the plasma membrane phospholipid ..
  12. Mechanisms in transcriptional regulation during cardiac hypertrophy
    Maha Abdellatif; Fiscal Year: 2013
    ..significantly, chromatin immunoprecipitation-deep sequencing analysis (ChIP-Seq) reveals that supplementing cardiac myocytes with miR-1 suppresses de novo pol II recruitment on a subset of genes, while inducing pausing on another, in ..
  13. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..Reduced oxygen availability causes cellular damage and death, particularly in neurons (via stroke) or cardiac myocytes (via heart attack)...
  14. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..We have found that individual cardiac myocytes from these cells have prolonged action potential duration, probably from reduced potassium current...
  15. Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Jeffrey E Saffitz; Fiscal Year: 2010
    ..pathways, genetic expression profiles, and cellular structure and function properties apply to the cardiac myocytes and myocardial tissues of fish and humans3...
  16. Systems Analysis of Cardiac Chromatin Structure
    Thomas M Vondriska; Fiscal Year: 2013
    ..Adult cardiac myocytes reside primarily in interphase but are capable of large-scale changes in gene expression...
  17. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    ..with SERCA pump will be assessed using site directed mutagenesis, and adenoviral gene transfer into cardiac myocytes. In addition, we will determine how SLN interaction with SERCA pump affect the kinetics of the SR calcium ..
  18. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    ..Thus the first specific aim i to determine how SLO causes an increase in intracellular Ca2+ in cardiac myocytes and a decrease in calcium reuptake into storage pools...
  19. Modulation of Ca Control of Cardiac Myofibrils
    R John Solaro; Fiscal Year: 2013
    ..Our approach to Aim #1 includes i) analysis of expression of ssTnI in neonatal cardiac myocytes by gain and loss of function approaches to dissect the relative significance of thyroid related signaling in ..
  20. MECHANISMS OF MALADAPTATION IN HEART FAILURE
    Howard A Rockman; Fiscal Year: 2013
    ..that the identified minimal domain of the b1AR C-tail leads to CaMKII activation when overexpressed in rabbit cardiac myocytes. We will create adeno-associated virus (AAV6) constructs that overexpress the bAR swap mutants, infect these ..
  21. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013
    ..This is tested on progenitor/stem cells and cardiac myocytes in culture and in animal models...
  22. Redox Regulation of Kv Channels
    SRINIVAS TIPPARAJU; Fiscal Year: 2013
    ..of Kv channels, we will examine how metabolic inhibitors or components of ischemia affect Kv currents in cardiac myocytes isolated from wild-type, Kv2-null and Kv22:Y90F mice, and whether loss of Kv2 affects tissue injury and ..
  23. Regulation of IL-6-Type Cytokine Cardioprotective Signaling in the Ischemic Heart
    George W Booz; Fiscal Year: 2012
    ..to occur, we propose that the cellular redox status needs to be maintained and SOCS3 induction in cardiac myocytes must be minimal...
  24. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
    ..known about specific mechanisms that maintain the integrity of FA proteins and determine their stability in cardiac myocytes. One of the primary effectors of monitoring and degrading proteins is the Ubiquitin Proteasome System (UPS)...
  25. Modulating calcineurin signaling pathways in muscle
    Beverly A Rothermel; Fiscal Year: 2012
    ..this portion of the proposal we will use both in vitro and in vivo techniques to test whether RCAN1 protects cardiac myocytes from oxidative damage and assess the involvement of mechanisms studied in Aims 1 and 2 in this process...
  26. Stem cells and the fibroblast/adipocyte lineage in arrhythmogenic cardiomyopathy
    Karen L Vikstrom; Fiscal Year: 2010
    ..Much attention has been given to the changes that occur in cardiac myocytes following disruption of the desmosome...
  27. MRP4 extrudes cAMP for localized regulation of calcium channel activity
    OLIVIA RUTH BUONARATI; Fiscal Year: 2013
    ..a membrane transporter that facilitates cellular extrusion of cAMP in kidney, prostate, gut epithelium, and cardiac myocytes. MRP4 is implicated in the transport of cyclic nucleotides and xenobiotic molecules at the blood-brain ..
  28. Cardiac function and PIP2
    Donald W Hilgemann; Fiscal Year: 2013
    ..trafficking events at the cell surface, starting with immortalized fibroblasts and proceeding to adult cardiac myocytes. Exploiting unprecedented control of the cytoplasmic milieu with high resolution capacitance recording, we ..
  29. Membrane-associated PDE3-binding proteins in human myocardium
    Matthew A Movsesian; Fiscal Year: 2013
    ..In cardiac myocytes, PDE3 activity is found in intracellular compartments represented in cytosolic and microsomal fractions...
  30. The role of phosphorylation of Ulk1 by GSK-3b in myocardial autophagy and aging
    Peiyong Zhai; Fiscal Year: 2013
    ..Glucose deprivation of neonatal rat cardiac myocytes will be used as a model to stimulate autophagy...
  31. Protein Kinase C Isozymes in Ischemic Heart
    Daria Mochly-Rosen; Fiscal Year: 2013
    ..mediated by delta PKC that we have designed, reduced reperfusion injury by 50-70%, as measured in isolated cardiac myocytes, and in rat, mouse and pig models of myocardial infarction...
  32. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2013
    ..effectors which positively and negatively couple to mechanical stretch-induced Ao gene expression in cardiac myocytes and fibroblasts...
  33. CVD protection mechanisms involving ACE2/Ang-(1-7) axis
    Mohan K Raizada; Fiscal Year: 2013
    ..ACE2 or Ang-(1-7) to the site of cardiac injury, would increase vasculogenesis, and protect and regenerate cardiac myocytes leading to a long-term beneficial outcome in HD...
  34. The S1P1 receptor regulates sarcomere assembly and cardiac development
    Roland S Wu; Fiscal Year: 2013
    ..These abnormalities appear to be specific to cardiac myocytes. In Aim 1, the timing of S1P1 function in zebrafish cardiac development will be examined...
  35. Nitroso/redox balance in myocardial infarction
    Joshua M Hare; Fiscal Year: 2013
    ..and others have shown that specific NO synthase (NOS) isoforms reside in precise sub-cellular organelles in cardiac myocytes and interact with oxidative enzymes in a spatially confined matter...
  36. CYTOPROTECTIVE EFFECTS OF INFLAMMATION MEDIATED MEMBRANE REPAIR
    DOUGLAS LOWELL MANN; Fiscal Year: 2013
    ..was the only signaling protein that was common to both receptors, we have performed experiments in isolated cardiac myocytes, as well as transgenic mice with cardiac restricted overexpression of TRAF2 (MHC-TRAF2 mice) and a dominant ..
  37. Epigenetic modification of endothelial progenitor cells into multipotent cells
    Rajasingh Johnson; Fiscal Year: 2010
    ..patients with acute myocardial infarction and chronic heart failure, achieving the consistent regeneration of cardiac myocytes would still of great interest...
  38. Regulation of Cardiac Calcium Channels by an Autoinhibitory Signalling Complex
    William A Catterall; Fiscal Year: 2013
    ..provided by applicant): Voltage-gated calcium (Ca) channels initiate excitation-contraction coupling in cardiac myocytes. Stimulation of the sympathetic nervous system activates [unreadable]-adrenergic receptors, adenylyl cyclase, ..
  39. FKBP Interaction with RYR Calcium Channels in Heart
    Donald M Bers; Fiscal Year: 2013
    ..we will define the molecular architecture of the FKBP/RyR interaction, and test its functional relevance in cardiac myocytes and isolated SR and RyRs (using fluorescent- tagged FKBP and fluorescence resonance energy transfer (FRET)...
  40. Cardiac Dystrophy: Cellular Mechanisms
    NATALIA V SHIROKOVA; Fiscal Year: 2013
    ..An elevated [Na+]i limits the ability of the sarcolemmal Na+-Ca2+ exchanger to extrude Ca2+ from dystrophic cardiac myocytes, thus promoting Ca2+ accumulation in the cytosol and consequently cellular damage. 2b)...
  41. Nuclear mechanics and mechanotransduction in muscular laminopathies
    Jan Lammerding; Fiscal Year: 2013
    ..By using a genetic reporter assay that can detect even transiently compromised nuclear envelope integrity in cardiac myocytes in three mouse models of muscular laminopathies, we can directly assess whether mutations in nuclear envelope ..
  42. Mechanisms of cardiac Ca dysregulation and arrhythmias in ankyrin B deficiency
    Sanda Despa; Fiscal Year: 2013
    ..Na]i and [Ca]i (in the bulk and junctional cleft), patch-clamp and molecular biology techniques in isolated cardiac myocytes in three Specific Aims...
  43. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..One leading hypothesis is that abnormal cell-cell adhesion injures cardiac myocytes and promotes cell death and subsequent replacement by fibro-fatty tissue...
  44. Metabolic Oscillations in Heart
    JAMES N contact WEISS; Fiscal Year: 2010
    ..been characterized extensively in yeast and pancreatic ?-cells, but conditions promoting their occurrence in cardiac myocytes are less established, compared to reactive oxygen species (ROS)-induced metabolic oscillations arising from ..
  45. Novel Aspects of the Cardiac Renin-Angiotensin System
    KENNETH MELVIN BAKER; Fiscal Year: 2012
    ..We reported that cardiac myocytes synthesize high levels of Ang II intracellularly, which redistributes to cytoplasm and nucleus, without ..
  46. Mechanisms of Tolerance to Renal Maternal Microchimerism
    ANNE MARGUERITE STEVENS; Fiscal Year: 2011
    ..The PI has found maternal cells in infant organs differentiated into hematopoietic cells, cardiac myocytes, hepatocytes, and renal tubular epithelial cells...
  47. Inflammation, fibrosis and myocardial function in schleroderma
    Dorothee Weihrauch; Fiscal Year: 2012
    ..matrix instability, induced by defect fibrillin-1, activates cultured fibroblasts, endothelial cells and cardiac myocytes isolated from Tsk-/+ and C57BL/6 mice...
  48. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..termed TRAF2 (tumor necrosis factor receptor associated factor 2), we have performed experiments in isolated cardiac myocytes, as well as transgenic mice with cardiac restricted overexpression of TRAF2 (MHC-TRAF2 mice) and a dominant ..
  49. Deciphering the role of the RNA-binding protein, FXR1, in cardiac muscle assembly
    Carol C Gregorio; Fiscal Year: 2013
    ..These experiments will be complemented by siRNA knock-down coupled with live-cell imaging in primary cardiac myocytes;2) identify mRNA targets of, and determine the manner in which they are regulated by FXR1 using both ..
  50. Regulatory Mechanisms of Oxidative Stress in Hypertensive Heart Disease
    Karl T Weber; Fiscal Year: 2013
    ..redox state is rooted in parathyroid hormone (PTH)- mediated intracellular Ca2+ overloading, including cardiac myocytes and mitochondria and PBMC, and where the rate of reactive oxygen species (ROS) generation overwhelms the rate ..
  51. Regulation of sympathetic function by infarction
    Beth A Habecker; Fiscal Year: 2013
    ..NE and ACh, which have opposing actions on cardiac myocytes, are not normally present in the same region of the left ventricle...
  52. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2009
    ..from increased reactive oxygen species (ROS) derived from nitric oxide synthase (NOS)-uncoupling in isolated cardiac myocytes and cardiopulmonary endothelial cells...
  53. Nanion Syncro Patch 96
    Gordana Vunjak-Novakovic; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Electrophysiological studies of electrically excitable cells, such as cardiac myocytes, skeletal myoblasts, neurons, osteoblasts, are critically important for the derivation of these cells from ..
  54. SUMO1 and SERCA2a Function
    Roger J Hajjar; Fiscal Year: 2013
    ..of calcium ions which has been shown to be related to abnormal sarcoplasmic reticulum (SR) function in cardiac myocytes. Reduced expression and activity of SERCA2a have been shown in multiple animal models of heart failure and in ..
  55. CHRONIC ADAPTATIONS TO MYOCARDIAL ISCHEMIA
    John M Canty; Fiscal Year: 2013
    ..demonstrated to improve function after intracoronary injection through both di- rect differentiation into cardiac myocytes as well as by stimulating endogenous myocyte proliferation...
  56. Mcl-1 as an essential regulator of cardiac mitochondrial function
    Asa B Gustafsson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mitochondria play critical roles in both the life and death of cardiac myocytes. They are important generators of energy, providing ATP through oxidative phosphorylation...
  57. Alpha-1A-adrenergic agonist therapy for cardiomyopathy and heart failure
    Paul C Simpson; Fiscal Year: 2013
    ..Successful completion of these Aims will provide essential pre-clinical validation of a potential new therapy in CM and HF, and will define a novel endogenous alpha-1A protective and adaptive mechanism in cardiac myocytes.
  58. Novel function and mechanism of CFTR in heart failure
    DAYUE DARREL DUAN; Fiscal Year: 2012
    ..The short-term goal is to explore the functional and mechanistic bases of CFTR in the protection of cardiac myocytes against oxidative stress damage inflicted during myocardial hypertrophy and heart failure...
  59. Cardiomyocyte stretch and intracellular calcium release with advancing age
    TIMOTHY LEE DOMEIER; Fiscal Year: 2013
    ..e., passive stretching of cardiac myocytes) an calcium release from the SR. To directly observe well-defined functional elements (e.g...
  60. NEUROFIBROMIN, NEURAL CREST AND CARDIAC DEVELOPMENT
    Jonathan A Epstein; Fiscal Year: 2012
    ..functions in vascular endothelium and smooth muscle;and preliminary data indicates that Nf1 is important in cardiac myocytes as well...
  61. Structure and Function of Sodium-Calcium Exchangers
    DINESH A YERNOOL; Fiscal Year: 2013
    ..Ca2+ using preexisting Na+-gradient potentials is critical to the normal function of excitable cells such as cardiac myocytes and neurons...
  62. MAVS protein: A role of mitochondria in innate immunity and cardioprotection
    Kirk Peterson; Fiscal Year: 2013
    ..This will contribute to our long-term goal of understanding the molecular mechanisms by which the cardiac myocytes defend themselves against various stresses and maintain homeostasis for a long period of time...
  63. PH AND MYOCARDIAL CONTRACTILITY
    Donghee Kim; Fiscal Year: 1992
    ..Intact cultured and freshly dissociated cardiac myocytes will be used for these studies because they allow accurate sequential measurements of transsarcolemmal ion ..
  64. LIGHT STIMULATED CARDIAC PACING AND DEFIBRILLATION
    JULIET MORGAN; Fiscal Year: 1991
    ..idea is based on the observation that light can increase the beating rate of neonatal rat and embryonic chick cardiac myocytes. With the light intensity normally used for phase contrast viewing, a 60% increase in beating rate was ..
  65. BLOOD FLOW AND ADENINE NUCLEOTIDE METABOLISM
    ROBERT BERNE; Fiscal Year: 1992
    ..relaxes vascular smooth muscle (VSM using endothelial-denuded arterial rings and co-cultured VSM cells, 2) in cardiac myocytes, to what extent adenosine is formed in the cytosol, whether the intracellular concentration can be increased ..
  66. IN VITRO MODEL OF PRECONDITIONING WITH ISOLATED MYOCYTES
    CHARLES GANOTE; Fiscal Year: 2001
    ..Investigator's Abstract) This is a proposal to study mechanisms of ischemic preconditioning using isolated cardiac myocytes from rabbits, as an example of an animal with a fast heart rate, and from pigs, as an example of an animal ..
  67. Role of ATM in Cardiac Myocyte Loss and Myocardial Remodeling
    Krishna Singh; Fiscal Year: 2009
    ..Regulation of ATM gene expression and activity in postmitotic cardiac myocytes, and its role in apoptosis, necrosis and myocardial remodeling is not known...
  68. EXPRESSION & FUNCTION OF HLA ANTIGEN ON CARDIAC MYOCYTES
    Aftab Ansari; Fiscal Year: 1990
    Normal human fetal and adult cardiac myocytes do not express detectable levels of either MHC Class I or Class II histocompatibility antigens...
  69. CARDIAC DISEASE IN COOLEYS ANEMIA--MOLE AND CLIN STUDIES
    Gary Brittenham; Fiscal Year: 2002
    ..and clinical consequences of iron-induced cardiac disease using a coordinated series of studies of cardiac myocytes in culture, of the first animal model of the cardiomyopathy of iron overload, and of patients with ..