multipotent stem cells

Summary

Summary: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)

Top Publications

  1. ncbi Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers
    Giampiero La Rocca
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Via del Vespro 129, 90127, Palermo, Italy
    Histochem Cell Biol 131:267-82. 2009
  2. ncbi Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    M Dominici
    Laboratory of Cell Biology and Advanced Cancer Therapy, Oncology Hematology Department, University of Modena and Reggio Emilia, Modena, Italy
    Cytotherapy 8:315-7. 2006
  3. pmc Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes
    Séverine Kirchner
    Department of Developmental and Cell Biology, 2011 Biological Sciences 3, University of California, Irvine, California 92697 2300, USA
    Mol Endocrinol 24:526-39. 2010
  4. ncbi Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
    E M Horwitz
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytotherapy 7:393-5. 2005
  5. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  6. ncbi Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    Ichiro Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Stem Cells 20:530-41. 2002
  7. pmc Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL 60612, USA
    BMC Med 10:3. 2012
  8. ncbi Isolation and characterization of multipotent skin-derived precursors from human skin
    Jean G Toma
    Department of Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Stem Cells 23:727-37. 2005
  9. pmc Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Clin Invest 115:326-38. 2005
  10. ncbi Yield of human adipose-derived adult stem cells from liposuction aspirates
    L Aust
    Artecel Sciences, Inc, Durham, NC, USA
    Cytotherapy 6:7-14. 2004

Detail Information

Publications321 found, 100 shown here

  1. ncbi Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers
    Giampiero La Rocca
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Via del Vespro 129, 90127, Palermo, Italy
    Histochem Cell Biol 131:267-82. 2009
    ....
  2. ncbi Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    M Dominici
    Laboratory of Cell Biology and Advanced Cancer Therapy, Oncology Hematology Department, University of Modena and Reggio Emilia, Modena, Italy
    Cytotherapy 8:315-7. 2006
    ....
  3. pmc Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes
    Séverine Kirchner
    Department of Developmental and Cell Biology, 2011 Biological Sciences 3, University of California, Irvine, California 92697 2300, USA
    Mol Endocrinol 24:526-39. 2010
    ..Hence, TBT alters the stem cell compartment by sensitizing multipotent stromal stem cells to differentiate into adipocytes, an effect that could likely increase adipose mass over time...
  4. ncbi Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
    E M Horwitz
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytotherapy 7:393-5. 2005
    ..The International Society for Cellular Therapy (ISCT) encourages the scientific community to adopt this uniform nomenclature in all written and oral communications...
  5. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  6. ncbi Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    Ichiro Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Stem Cells 20:530-41. 2002
    ..The results indicate that, when preparing cultures of human MSCs, it is necessary to compromise between conditions that provide the highest overall yields and those that provide the highest content of early progenitor cells...
  7. pmc Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL 60612, USA
    BMC Med 10:3. 2012
    ..Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can control autoimmune responses by altering regulatory T cells (Tregs) and human islet β cell-..
  8. ncbi Isolation and characterization of multipotent skin-derived precursors from human skin
    Jean G Toma
    Department of Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Stem Cells 23:727-37. 2005
    ..Together, these data indicate that SKPs are an endogenous multipotent precursor cell present in human skin that can be isolated and expanded and differentiate into both neural and mesodermal cell types...
  9. pmc Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction
    Young Sup Yoon
    Division of Cardiovascular Medicine, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    J Clin Invest 115:326-38. 2005
    ..Based on surface marker expression, these clonally expanded human BM-derived multipotent stem cells (hBMSCs) do not appear to belong to any previously described BM-derived stem cell population...
  10. ncbi Yield of human adipose-derived adult stem cells from liposuction aspirates
    L Aust
    Artecel Sciences, Inc, Durham, NC, USA
    Cytotherapy 6:7-14. 2004
    ..Primary cultures of isolated human adipose-derived adult stem (ADAS) cells are multipotent and differentiate in vitro along the adipocyte, chondrocyte, neuronal, osteoblast, and skeletal muscle pathways...
  11. ncbi Pluripotent and multipotent stem cells in adult tissues
    M Z Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Kentucky, USA
    Adv Med Sci 57:1-17. 2012
    ..These different populations of stem cells will be reviewed in this paper...
  12. ncbi Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells
    Paola Bonfanti
    Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Nature 466:978-82. 2010
    ..These cells can irreversibly adopt the fate of hair follicle multipotent stem cells when exposed to an inductive skin microenvironment; this change in fate is correlated with robust changes ..
  13. pmc Generation of functional multipotent adult stem cells from GPR125+ germline progenitors
    Marco Seandel
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York 10065, USA
    Nature 449:346-50. 2007
    ....
  14. ncbi Mesenchymal stem cells for clinical application
    L Sensebe
    Etablissement Français du Sang GECSoM, Tours cedex 3, France
    Vox Sang 98:93-107. 2010
    ..For answering to the numerous challenges in this fast developing field of biology and medicine, integrative networks linking together research teams, cell therapy laboratories and clinical teams are needed...
  15. ncbi Multipotent stem cells from umbilical cord: cord is richer than blood!
    Mariane Secco
    Human Genome Research Center, Department of Genetic and Evolutive Biology, University of Sao Paulo, Rua do Matao, n 106, Cidade Universitaria, Sao Paulo, SP, CEP 05508 090, Brazil
    Stem Cells 26:146-50. 2008
    ....
  16. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  17. ncbi Human mesenchymal stem cells modulate allogeneic immune cell responses
    Sudeepta Aggarwal
    Osiris Therapeutics, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Blood 105:1815-22. 2005
    ....
  18. ncbi Stem cells and their niches
    Kateri A Moore
    Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, NJ 08544, USA
    Science 311:1880-5. 2006
    ..We focus on three mammalian stem cell systems where large numbers of mature cells must be continuously produced throughout adult life: intestinal epithelium, epidermal structures, and bone marrow...
  19. pmc Facile isolation and the characterization of human retinal stem cells
    Brenda L K Coles
    Departments of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:15772-7. 2004
    ..Their facile isolation, integration, and differentiation suggest that human RSCs eventually may be valuable in treating human retinal diseases...
  20. ncbi The biliary tree--a reservoir of multipotent stem cells
    Vincenzo Cardinale
    Division of Gastroenterology, Department of Medico Surgical Sciences and Biotechnology, Fondazione Eleonora Lorillard Spencer Cenci, Polo Pontino, Corso della Repubblica 79, 04100 Latina, Italy
    Nat Rev Gastroenterol Hepatol 9:231-40. 2012
    ..Peribiliary glands contain multipotent stem cells, which self-replicate and can differentiate into hepatocytes, cholangiocytes or pancreatic islets, ..
  21. pmc Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment
    Yoshinori Nagai
    Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Immunity 24:801-12. 2006
    ..Thus, the preferential pathogen-mediated stimulation of myeloid differentiation pathways may provide a means for rapid replenishment of the innate immune system during infection...
  22. ncbi Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture
    Shinsuke Tada
    Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Development 132:4363-74. 2005
    ..Finally, we show that the defined culture condition and surface markers developed in this study are applicable for obtaining pure mesendodermal cells and their immediate progenies from genetically unmanipulated ES cells...
  23. ncbi Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice
    Fernando E Ezquer
    Instituto de Ciencias, Facultad de Medicina, Clinica Alemana Universidad Del Desarrollo, Santiago, Chile
    Biol Blood Marrow Transplant 14:631-40. 2008
    ..Our preclinical results suggest bone marrow-derived MSC transplantation as a cell therapy strategy to treat type 1 diabetes and prevent diabetic nephropathy, its main complication...
  24. ncbi Pluripotent embryonic stem cells and multipotent adult germline stem cells reveal similar transcriptomes including pluripotency-related genes
    S Meyer
    Institute of Human Genetics, Georg August University Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    Mol Hum Reprod 16:846-55. 2010
    ..This is the first study, at transcriptome level, to compare ESCs and a pluripotent cell line derived from an adult organism (maGSCs)...
  25. ncbi Isolation procedure and characterization of multipotent adult progenitor cells from rat bone marrow
    Kartik Subramanian
    Department of Chemical Engineering and Materials Science, Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA
    Methods Mol Biol 636:55-78. 2010
    ..We elaborate on several aspects of the isolation protocol including, cell density and medium components, and methods for selecting and obtaining potential MAPC clones and their characterization...
  26. ncbi Placenta-derived multipotent stem cells induced to differentiate into insulin-positive cells
    Chia Ming Chang
    Department of Obstetrics and Gynecology, Taipei, Taiwan
    Biochem Biophys Res Commun 357:414-20. 2007
    ..The potential of these insulin producing cells derived from PDMSCs was also demonstrated functionally by the demonstration of secreted insulin in vitro and effective control of blood glucose levels in vivo...
  27. ncbi Lectin microarray analysis of pluripotent and multipotent stem cells
    Masashi Toyoda
    Department of Reproductive Biology, National Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Genes Cells 16:1-11. 2011
    ..These results suggest that glycomic analysis of stem cells leads to a novel comprehensive approach for quality control in cell-based therapy and regenerative medicine...
  28. pmc Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
    Ji Won Jung
    Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
    Cell Mol Life Sci 67:1165-76. 2010
    Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular senescence in vitro...
  29. ncbi Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis
    Elena A Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 50:817-27. 2004
    ..To evaluate synovial fluid (SF) for the presence of mesenchymal progenitor cells (MPCs), to compare SF MPCs with bone marrow (BM) MPCs, and to enumerate these cells in both inflammatory arthritis and osteoarthritis (OA)...
  30. ncbi Isolation of multipotent cells from human term placenta
    B Linju Yen
    Stem Cell Research Center, National Health Research Institutes, Min Chuan E Road, Taipei, 114, Taiwan
    Stem Cells 23:3-9. 2005
    ..PDMCs could provide an ethically uncontroversial and easily accessible source of multipotent cells for future experimental and clinical applications...
  31. pmc Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells
    Nina Kossack
    Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California 94304 5542, USA
    Stem Cells 27:138-49. 2009
    ..Thus, these data suggest the potential to derive pluripotent cells from human testis biopsies but indicate a need for novel strategies to optimize hMGSC culture conditions and reprogramming...
  32. pmc Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart
    Yuichi Tomita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cell Biol 170:1135-46. 2005
    ..results suggest that cardiac neural crest-derived cells migrate into the heart, remain there as dormant multipotent stem cells-and under the right conditions-differentiate into cardiomyocytes and typical neural crest-derived cells, ..
  33. ncbi Pluripotency of spermatogonial stem cells from adult mouse testis
    Kaomei Guan
    Department of Cardiology and Pneumology, Heart Center, Georg August University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Nature 440:1199-203. 2006
    ..Furthermore, these cells may provide new opportunities to study genetic diseases in various cell lineages...
  34. pmc Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse
    Anne Marie Rodriguez
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 Centre National de la Recherche Scientifique, 06108 Nice Cedex 2, France
    J Exp Med 201:1397-405. 2005
    ....
  35. ncbi Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both?
    Chien Wen Chen
    Stem Cell Research Center, Children s Hospital of Pittsburgh and UPMC, Pittsburgh, PA 15213, USA
    Cytokine Growth Factor Rev 20:429-34. 2009
    ..Pericytes can differentiate into diverse cell lineages, but also secrete multiple paracrine growth factors/cytokines, which likely explains in part their robust regenerative potential...
  36. pmc Long-term renewal of hair follicles from clonogenic multipotent stem cells
    Stéphanie Claudinot
    Laboratory of Stem Cell Dynamics, Ecole Polytechnique Fédérale de Lausanne and Lausanne University Hospital, Station 15, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 102:14677-82. 2005
    ....
  37. ncbi Multipotent stem cells from adult olfactory mucosa
    Wayne Murrell
    Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
    Dev Dyn 233:496-515. 2005
    b>Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa...
  38. ncbi Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation
    Amit N Patel
    Center for Cardiac Cell Therapy Heart Lung Esophageal Surgical Institute, University of Pittsburgh UPMC McGowan Institute of Regenerative Medicine, Pittsburgh, PA 15213, USA
    Cell Transplant 17:303-11. 2008
    ..These studies demonstrate the plasticity of MenSCs for potential research in regenerative medicine...
  39. ncbi Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells
    J Kim
    Department of Biotechnology, College of Natural Science, Seoul Women s University, Nowon Gu, Seoul, Korea
    Cell Prolif 40:75-90. 2007
    ..To characterize mesenchymal stem cell-like cells isolated from human amniotic fluid for a new source of therapeutic cells...
  40. ncbi Endothelial differentiation potential of human monocyte-derived multipotential cells
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Stem Cells 24:2733-43. 2006
    ..These findings indicate that human MOMCs can proliferate and differentiate along the endothelial lineage in a specific permissive environment and thus represent an autologous transplantable cell source for therapeutic neovasculogenesis...
  41. ncbi Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 118:635-48. 2004
    ..These findings suggest that the niche microenvironment imposes intrinsic "stemness" features without restricting the establishment of epithelial polarity and changes in gene expression...
  42. pmc The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical School, Saitama 350 1241, Japan
    Mol Cell Biol 24:4207-20. 2004
    ..Thus, SRR2 is the first example of an enhancer in which a single regulatory core sequence is involved in multipotent-state-specific expression in two different stem cells, i.e., ES and neural stem cells...
  43. ncbi Perivascular ancestors of adult multipotent stem cells
    Mirko Corselli
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Arterioscler Thromb Vasc Biol 30:1104-9. 2010
    ..Recent experiments illustrate the therapeutic potential of human pericytes to regenerate skeletal muscle and promote functional recovery in the diseased heart and kidney...
  44. pmc Multipotent stem cells in human corneal stroma
    Yiqin Du
    University of Pittsburgh Medical Center Eye Center, 1009 Eye and Ear Institute, 203 Lothrop St, Pittsburgh, PA 15213 2588, USA
    Stem Cells 23:1266-75. 2005
    ..Further analysis of these cells will aid elucidation of molecular mechanisms of corneal development, differentiation, and wound healing. These cells may be a resource for bioengineering of corneal stroma and for cell-based therapeutics...
  45. ncbi Stable expression of a neuronal dopaminergic progenitor phenotype in cell lines derived from human amniotic fluid cells
    David McLaughlin
    Neuroscience Division, Institute for Biomedical Research of the Academy of Athens, Athens, Greece
    J Neurosci Res 83:1190-200. 2006
    ..Our data show that cell lines can be derived from subcultures of amniocentesis, and are primarily composed of a population of progenitors with a phenotype similar to that of committed mesencephalic dopaminergic neurons...
  46. ncbi Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation
    Zhifeng Xiao
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Cell Res 17:73-9. 2007
    ..Collectively, this study may provide insight into the mechanisms by which microenvironmental niche signals regulate NSCs...
  47. ncbi Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells
    Hongzhen Li
    Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Exp Cell Res 314:92-102. 2008
    ..The results indicate that RC170N/h/clone 7 cells retain the properties of multipotent stem cells and will be useful as a novel cell model for studying the mechanisms of human prostate stem cell ..
  48. ncbi Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Développement et Cander, UMR6543 Centre National de la Recerche Scientifique, Centre de Biochimie, Faculte des Sciences, Université Nice Sophia Antiplis, Nice, France
    Stem Cells 24:2412-9. 2006
    ..Together, our data clearly identify the key function of FGF2 in the maintenance of self-renewal of adipose tissue-derived stem cells...
  49. ncbi Heterogeneity of Flt3-expressing multipotent progenitors in mouse bone marrow
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:5016-23. 2005
    ..These results establish a hierarchy of developmental relationship between MPP subsets and lymphoid and myeloid progenitors. In addition, VCAM-1(+) MPPs may represent the branching point between the lymphoid and myeloid lineages...
  50. ncbi Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye
    Angus Macneil
    Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL UK
    Stem Cells 25:2430-8. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  51. ncbi Neural stem cell systems: physiological players or in vitro entities?
    Luciano Conti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Via Balzaretti 9, Milan, Italy
    Nat Rev Neurosci 11:176-87. 2010
    ..A better understanding of these systems will be crucial to control NSC fate and functional integration following transplantation and to make NSCs suitable for regenerative efforts following injury or disease...
  52. ncbi The regulation of tendon stem cell differentiation by the alignment of nanofibers
    Zi Yin
    Center for Stem Cell and Tissue Engineering, Department of Sports Medicine, School of Medicine, Zhejiang University, and Department of Orthopedic Surgery, 2nd Affiliated Hospital, Hangzhou, China
    Biomaterials 31:2163-75. 2010
    ..In conclusion, the aligned electrospun nanofiber structure provides an instructive microenvironment for hTSPC differentiation and may lead to the development of desirable engineered tendons...
  53. ncbi Human inferior turbinate: an alternative tissue source of multipotent mesenchymal stromal cells
    Se Hwan Hwang
    Department of Otolaryngology Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 147:568-74. 2012
    ..This study aimed to explore potential new sources of multipotent MSCs for use in tissue regeneration and the functional restoration of organs...
  54. ncbi Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells
    Jacek Klaudiusz Pijanka
    Institute for Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Stoke on Trent, UK
    Analyst 135:3126-32. 2010
    ..While vibrational spectroscopy could therefore be of potential use in identifying different populations of stem cells further work is required to better understand these differences...
  55. ncbi Obesity short-circuits stemness gene network in human adipose multipotent stem cells
    Mar Roldan
    Fundacion Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria IMABIS, Malaga, Spain
    FASEB J 25:4111-26. 2011
    The discovery of adipose multipotent stem cells has provided new insights to explore cellular mechanisms involved in adipose tissue function...
  56. pmc Isolation of novel multipotent neural crest-derived stem cells from adult human inferior turbinate
    Stefan Hauser
    Molecular Neurobiology, University of Bielefeld, Bielefeld, Germany
    Stem Cells Dev 21:742-56. 2012
    ..Taken together our study describes a novel, readily accessible source of multipotent human NCSCs for potential cell-replacement therapy...
  57. pmc Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
    F Cavaliere
    Department of Neurosciences and CIBERNED, University of Basque Country UPV EHU, E 48940 Leioa, Spain
    Cell Death Dis 3:e268. 2012
    We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation...
  58. pmc Multipotent stem cells from trabecular meshwork become phagocytic TM cells
    Yiqin Du
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 53:1566-75. 2012
    ..To isolate and characterize stem cells from human trabecular meshwork (TM) and to investigate the potential of these stem cells to differentiate into TM cells...
  59. pmc Defining stem and progenitor cells within adipose tissue
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Stem Cells Dev 17:1053-63. 2008
    ..Isolated, ADSC can be induced to differentiate into additional cell types such as osteoblasts and chondrocytes...
  60. pmc Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineages
    Lauren Crigler
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    FASEB J 21:2050-63. 2007
    ..Moreover, these cells could be available in sufficient quantities for lineage determination or tissue engineering applications...
  61. ncbi bFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells
    Sang Bum Park
    Laboratory of Stem Cell and Tumor Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, South Korea
    Growth Factors 27:425-37. 2009
    ..In human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs), bFGF is associated with an increased number of proliferating cells...
  62. ncbi Global and gene-specific histone modification profiles of mouse multipotent adult germline stem cells
    Tatjana Khromov
    Institute of Human Genetics, Georg August University Goettingen, Heinrich Dueker Weg 12, 37073 Goettingen, Germany
    Mol Hum Reprod 17:166-74. 2011
    ..Collectively, our results demonstrate that maGSCs also closely resemble ESCs with regard to their chromatin state and further evidence their pluripotent nature...
  63. ncbi Differentiation of dermis-derived multipotent cells into insulin-producing pancreatic cells in vitro
    Chun Meng Shi
    Institute of Combined Injury, Third Military Medical University, Gaotanyan 400038, Chongqing City, China
    World J Gastroenterol 10:2550-2. 2004
    ..To observe the plasticity of whether dermis-derived multipotent cells to differentiate into insulin-producing pancreatic cells in vitro...
  64. ncbi Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell-conditioned medium
    Na Huo
    Department of Orthodontics, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Stem Cells Dev 19:93-104. 2010
    ..Our work highlights the potential utility of DMCs as an alternative candidate cell source in hopes of developing more practical strategy of tooth regeneration research and offering promising opportunities for therapeutic approach...
  65. ncbi Pre-clinical safety testing supporting clinical use of allogeneic multipotent adult progenitor cells
    M Kovacsovics-Bankowski
    Center for Hematologic Malignancies, OHSU Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA
    Cytotherapy 10:730-42. 2008
    ....
  66. pmc Modeling sarcomagenesis using multipotent mesenchymal stem cells
    Rene Rodriguez
    Pfizer University of Granada Andalusian Government Centre for Genomics and Oncological Research GENyO, Parque Tecnológico de Ciencias de la Salud, Granada, Spain
    Cell Res 22:62-77. 2012
    ..Here, we comprehensively review the existing MSC-based models of sarcoma and discuss the most common mechanisms leading to tumoral transformation of MSCs and sarcomagenesis...
  67. ncbi Isolation, characterization, and differentiation potential of canine adipose-derived stem cells
    N M Vieira
    Human Genome Research Center, Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil
    Cell Transplant 19:279-89. 2010
    ..In conclusion, like human lipoaspirate, canine adipose tissue may also contain multipotent cells and represent an important stem cell source both for veterinary cell therapy as well as preclinical studies...
  68. ncbi Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain
    Noah M Walton
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Development 133:3671-81. 2006
    ..These findings suggest an unprecedented degree of inducible plasticity is retained by cells of the adult central nervous system...
  69. ncbi Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
    Friederike Gieseke
    University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
    Blood 116:3770-9. 2010
    ..These results identify galectin-1 as the first lectin mediating the immunomodulatory effect of MSCs on allogeneic T cells...
  70. ncbi Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1
    Hideyuki Oguro
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Cell Stem Cell 6:279-86. 2010
    ..Thus, Bmi1 is required to reinforce bivalent domains at key developmental regulator gene loci to maintain lineage specification poised for activation in adult stem cells...
  71. ncbi Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice
    Ashish K Rehni
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India
    Behav Brain Res 183:95-100. 2007
    ..Therefore, it may be concluded that stem cells derived from amniotic fluid exert beneficial effect on the ischaemic brain to an extent comparable to the neuroprotective effect of embryonic neuronal stem cells...
  72. ncbi Matrix cells from Wharton's jelly form neurons and glia
    Kathy E Mitchell
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
    Stem Cells 21:50-60. 2003
    We have identified an easily attainable source of primitive, potentially multipotent stem cells from Wharton's jelly, the matrix of umbilical cord...
  73. ncbi Oligodendrocytes and radial glia derived from adult rat spinal cord progenitors: morphological and immunocytochemical characterization
    Iris Kulbatski
    Institute of Medical Science, University of Toronto, Toronto, Canada
    J Histochem Cytochem 55:209-22. 2007
    ..These findings indicate that adult rat spinal cord ependymal NPCs differentiate preferentially into oligodendrocytes and RG, which may support axonal regeneration in future trials of transplant therapy for spinal cord injury...
  74. pmc Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
    Zia A Khan
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2592-9. 2008
    ..In summary, this study identifies a stem cell as the cellular origin of infantile hemangioma and describes for what we believe is the first time an animal model for this common tumor of infancy...
  75. pmc Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice
    Ali H Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA 70112, USA
    Lab Invest 90:985-96. 2010
    ..Our novel study data provide evidence that in type II diabetes, stimulated MSCs with EGF enhance the recovery of blood flow and angiogenesis...
  76. ncbi Defining a developmental path to neural fate by global expression profiling of mouse embryonic stem cells and adult neural stem/progenitor cells
    Kazuhiro Aiba
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Stem Cells 24:889-95. 2006
    ..We suggest that this PC1 defines a path to neural fate, providing a scale for the degree of commitment/differentiation...
  77. ncbi Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion
    Dolores Baksh
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada
    Exp Hematol 31:723-32. 2003
    ....
  78. ncbi Multipotent vasculogenic pericytes from human pluripotent stem cells promote recovery of murine ischemic limb
    Ayelet Dar
    Department of Ob Gyn, Rambam Health Care Campus, Haifa 31096, Israel
    Circulation 125:87-99. 2012
    ....
  79. ncbi Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 14:181-7. 2008
    ..These findings establish that the HCELL glycoform of CD44 confers tropism to bone and unveil a readily translatable roadmap for programming cellular trafficking by chemical engineering of glycans on a distinct membrane glycoprotein...
  80. ncbi Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Lab, Cancer Research UK, London Research Institute, UK
    Blood 109:1298-306. 2007
    ..Altogether we are proposing a hierarchical organization of the mesenchymal compartment, placing SSEA-1+ cells at the apex of this hierarchy...
  81. ncbi Human circulating monocytes as multipotential progenitors
    Noriyuki Seta
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Keio J Med 56:41-7. 2007
    ..These observations together indicate that circulating monocytes are more multipotential than previously thought. In addition, cell transplantation therapies using circulating monocytes are a potential approach for tissue regeneration...
  82. ncbi Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis
    Shih Chieh Hung
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2363-70. 2007
    ..The results are consistent with suggestions that administration of MSCs or factors secreted by MSCs may provide a therapeutic method of decreasing apoptosis and enhancing angiogenesis...
  83. ncbi Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    Hye Youn Lee
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 303:1020-3. 2004
    ..Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent...
  84. ncbi Anti-L-NGFR and -CD34 monoclonal antibodies identify multipotent mesenchymal stem cells in human adipose tissue
    Nadia Quirici
    Fondazione Matarelli, Department of Medical Pharmacology, Universita degli Studi di Milano, Milan, Italy
    Stem Cells Dev 19:915-25. 2010
    ..It has been recently shown that adipose tissue is an alternative source of adult multipotent stem cells and human adipose-derived stem cells, selected by plastic adherence (PA hASCs), have been extensively ..
  85. ncbi Concise review: challenging the pluripotency of human testis-derived ESC-like cells
    Natalia Tapia
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Munster, Germany
    Stem Cells 29:1165-9. 2011
    ..Here, we critically review these reports and provide insight to guide future studies on the derivation of human pluripotent cells from testicular tissue...
  86. ncbi A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study
    K S Kang
    Laboratory of Stem Cell and Tumor Biology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Cytotherapy 7:368-73. 2005
    HLA-matched UC blood-derived multipotent stem cells were directly transplanted into the injured spinal cord site of a 37-year-old female patient suffering from spinal cord injury (SPI)...
  87. ncbi Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Ann Neurol 66:343-54. 2009
    ....
  88. ncbi Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea
    Satoru Yoshida
    Cornea Center, Tokyo Dental College, Ichikawa, Chiba, Japan
    Stem Cells 24:2714-22. 2006
    ..Taken together, these data indicate the existence of neural crest-derived, multipotent stem cells in the adult cornea.
  89. ncbi "Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs)
    D J Prockop
    Tulane Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Clin Pharmacol Ther 82:241-3. 2007
    ....
  90. pmc Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
    Christine E Wong
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 175:1005-15. 2006
    ..These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin...
  91. ncbi Isolation of multipotent stem cells from mouse adipose tissue
    Naoki Yamamoto
    Laboratory of Molecular Biology and Histochemistry, Fujita Health University Joint Research Laboratory, 1 98 Toyoake, Aichi 470 1192, Japan
    J Dermatol Sci 48:43-52. 2007
    ..However, there is no specific surface antigen that can be used as a marker of multipotent stem cells.
  92. ncbi Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis
    Koichiro Iohara
    Laboratory of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Aichi, Japan
    Stem Cells 24:2493-503. 2006
    ..Thus, adult pulp contains SP cells, which are enriched for stem cell properties and useful for cell therapy with BMP2 for dentin regeneration...
  93. ncbi The human adipose tissue is a source of multipotent stem cells
    A M Rodriguez
    Faculte des Sciences, Centre de Biochimie, Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Biochimie 87:125-8. 2005
    b>Multipotent stem cells constitute an unlimited source of differentiated cells that could be used in pharmacological studies and in medicine...
  94. ncbi Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system
    Judith A Shizuru
    Division of Blood and Marrow Transplantation, Stanford University Medical Center, California 94305, USA
    Annu Rev Med 56:509-38. 2005
    ....
  95. ncbi Optimization of a flow cytometry-based protocol for detection and phenotypic characterization of multipotent mesenchymal stromal cells from human bone marrow
    Elena A Jones
    Academic Unit of Musculoskeletal Disease, Leeds Institute for Molecular Medicine, University of Leeds, Leeds, United Kingdom
    Cytometry B Clin Cytom 70:391-9. 2006
    ..The purpose of this work was to verify the phenotype of BM MSCs in vivo and to develop flow cytometry-based methods for their evaluation...
  96. pmc Multipotent adult progenitor cells sustain function of ischemic limbs in mice
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 118:505-14. 2008
    ..Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients...
  97. pmc Epithelial stem cells: turning over new leaves
    Cedric Blanpain
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Cell 128:445-58. 2007
    Most epithelial tissues self-renew throughout adult life due to the presence of multipotent stem cells and/or unipotent progenitor cells...
  98. ncbi Placenta-derived multipotent cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-gamma
    Chun Jung Chang
    Stem Cell Research Center, National Health Research Institutes, Zhunan, Taiwan
    Stem Cells 24:2466-77. 2006
    ..The immunosuppressive properties of PDMCs, along with their multilineage differentiation potential, ease of accessibility, and abundant cell numbers, may render these cells as good potential sources for future therapeutic applications...
  99. ncbi Stem cells derived from human fetal membranes display multilineage differentiation potential
    Sivakami Ilancheran
    Center for Women s Health Research, Department of Obstetrics and Gynecology, Monash University, Monash Medical Center, Clayton, Victoria 3168, Australia
    Biol Reprod 77:577-88. 2007
    ..These observations suggest that the term amnion, an abundant and easily accessible tissue, may be a useful source of multipotent stem cells that possess a degree of immune privilege.
  100. ncbi New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Autoimmun Rev 11:137-42. 2011
    ..This review focuses on recent progress in the use of immune modulation in T2D and discusses the potential for future therapies. New insights are provided on the use of cord blood-derived multipotent stem cells (CB-SC) in T2D.
  101. ncbi A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone
    Heng Zhu
    Department of Cell Biology, Institute of Basic Medical Sciences, Beijing, China
    Nat Protoc 5:550-60. 2010
    ..Further identification assays confirm that these cells are MSCs. We provide an easy and reproducible method to harvest mouse MSCs that does not require depletion of hematopoietic cells by sorting or immunomagnetic techniques...

Research Grants62

  1. Multipotent Stem Cells from Adult Rhesus Macaques
    TIMOTHY O BRIEN; Fiscal Year: 2006
    ..Relevance: Completion of these studies will expand our knowlegde of adult stem cells and greatly enhance our ability to develop and test adult stem cell therapies for future application to human diseases. ..
  2. CEREBRAL PROTECTION & RECOVERY AFTER CIRCULATORY ARREST
    Yan Xu; Fiscal Year: 2007
    ..Specific Aim #3: To devise a method for diffusive cerebral transplantation of multipotent stem cells and, in combination with BDNF and VEGF gene therapy, to study interaction of angiogenesis and neurogenesis...
  3. Cell therapy of diabetes using broad spectrum multipotent stem cells
    Shay Soker; Fiscal Year: 2007
    ..Preliminary studies with mouse AFS cells suggest that this approach can provide long-term reversal of diabetes. [unreadable] [unreadable] [unreadable]..
  4. INTERPLAYS BETWEEN THE JAW MESENCHYMAL STEM CELLS AND T LYMPHOCYTES
    Yufang Shi; Fiscal Year: 2010
    Bone marrow mesenchymal stem cells (BMMSCs) are multipotent stem cells capable of differentiating into different lineage cells including osteoblasts, chondrocytes, adipocytes, cardiomyocytes, myoblasts, and neural cells...
  5. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..that tissue-specific extracellular matrix provides a native microenvironment that governs the ability of multipotent stem cells seeded on Alloderm to both self-renew and differentiate into functional full-thickness oral mucosa ..
  6. Cell Adhesion and Cytoskeletal Dynamics in Skin
    Elaine Fuchs; Fiscal Year: 2013
    ..This research focuses on deciphering how different tissue structures are derived from multipotent stem cells in the skin...
  7. Establishment of Marmoset iPS-derived Cranial Neural Crest Cells
    Steven Farnsworth; Fiscal Year: 2013
    ..CNC cells are multipotent stem cells that during vertebrate development give rise to cranial Schwann cells, peripheral neurons, facial bone, ..
  8. Complex Nanocomposites for Bone Regeneration
    Antoni P Tomsia; Fiscal Year: 2013
    ..These will be tested in combination with autologous multipotent stem cells for the ability to promote bone formation in established medium-sized (rabbit) and large-sized (mini-pig) ..
  9. REGULATION OF INTESTINAL EPITHELIAL CELL PROLIFERATION
    Vincent W Yang; Fiscal Year: 2013
    ..Proliferation of multipotent stem cells and progenitor (also called transient amplifying) cells is confined to the crypt epithelium of the ..
  10. Regulation of adipocyte differentiation and metabolism
    Ormond A MacDougald; Fiscal Year: 2010
    ..expanded the role for Wnt10b from simple inhibition of preadipocyte differentiation to modulating fate of multipotent stem cells. Thus, FABP4-Wnt10b mice have a four-fold increase in trabecular bone...
  11. Epigenomic Mapping in Human Tumor Stem Cells
    Richard A Young; Fiscal Year: 2013
    ..will be isolated from the same source and the differences between tumor stem cells and pluripotent and multipotent stem cells will be examined...
  12. Mesenchymal stem cells and the microenvironment
    Christopher S Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human mesenchymal stem cells (MSCs) are multipotent stem cells that differentiate into many of the cells resident in musculoskeletal and stromal tissues of the human body, including fibroblasts, ..
  13. Nutrient regulation of stem cell mediated intestinal renewal in Drosophila
    LUCY ERIN O'BRIEN; Fiscal Year: 2013
    ..With the recent discovery that multipotent stem cells renew the intestinal lining in the adult Drosophila midgut, the powerful advantages of the Drosophila ..
  14. Heterogeneity of forebrain neural precursors
    Tarik F Haydar; Fiscal Year: 2013
    ..we have uncovered in vivo differences between classes of RGCs which suggest that not all RGCs are multipotent stem cells. Taken together, our published and Preliminary Data fundamentally alter our understanding of the ..
  15. Roles for Wnt signaling in adipose tissue
    Ormond A MacDougald; Fiscal Year: 2013
    ..expanded the role for Wnt10b from simple inhibition of preadipocyte differentiation to modulating fate of multipotent stem cells. Thus, FABP4-Wnt10b mice not only have less adipose tissue, but they have a four-fold increase in ..
  16. Neural crest formation and maintenance of multipotency
    Patricia Labosky; Fiscal Year: 2009
    ..have this intrinsic multipotency, they represent a system in which to explore molecular requirements of multipotent stem cells. Stem cells are a unique tissue with the potential for disease therapy and cell transplantation...
  17. Key nodes in the T-cell developmental gene regulatory network
    Ellen V Rothenberg; Fiscal Year: 2013
    ..T cell development is a model for the mechanism of cell fate choice starting from a physiological pool of multipotent stem cells. Mammalian T-cell development permits highly refined dissection of the process of lineage commitment, ..
  18. The effects of endogenous and dietary estrogens on colonic stem cells
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2013
    ..findings, we propose two specific aims to determine how endogenous (E2) and dietary estrogen (Gen) impact multipotent stem cells in the colon...
  19. Multipotent stem cells for tissue regeneration
    Song Li; Fiscal Year: 2013
    ..stem cell source and an ideal model system to study the lineage commitment and therapeutic potential of multipotent stem cells. In addition, nanofibrous biomaterials will be used as scaffolds to deliver stem cells and provide a well-..
  20. Optimal Generation and Characterization of iPS Cell Lines from Healthy and ADHD S
    Kwang Soo Kim; Fiscal Year: 2012
    ..To further advance our understanding of ADHD's molecular pathogenesis it is desirable to establish multipotent stem cells with the genetic backgrounds of ADHD and healthy subjects for biological and molecular comparisons...
  21. Optimal Generation and Characterization of iPS Cell Lines from Healthy and ADHD S
    Kwang Soo Kim; Fiscal Year: 2010
    ..To further advance our understanding of ADHD's molecular pathogenesis it is desirable to establish multipotent stem cells with the genetic backgrounds of ADHD and healthy subjects for biological and molecular comparisons...
  22. Identification of Novel Endothelial Progenitor Cells
    Young Sup Yoon; Fiscal Year: 2010
    ..BM-derived cells such as endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs) or similar multipotent stem cells are effective to repair or regenerate ischemic cardiovascular diseases...
  23. Development of humanized models using human induced pluripotent stem cells
    John K Critser; Fiscal Year: 2010
    ..reports have demonstrated that making mouse-human chimeras is possible and that human pluripotent and multipotent stem cells are able to respond to the spatial and temporal program of the mouse embryonic environment during ..
  24. Bladder Organogenesis and Tissue Regeneration Derived From Stem Cells
    Chester J Koh; Fiscal Year: 2012
    ..patients in whom suitable donor tissue does not exist, such as with bladder cancer or bladder agenesis, multipotent stem cells are envisioned as a potentially endless and viable source of cells from which the desired tissue can be ..
  25. Generation of therapeutic T cells from cord blood-derived stem cells
    Krishnendu Roy; Fiscal Year: 2009
    ..Therefore, technologies leading to efficient generation and expansion of therapeutic T cells from multipotent stem cells in a synthetic, controlled environment could provide a renewable, on-demand and readily available cell ..
  26. Myocardial Regeneration with Adult Stem Cells
    Young Sup Yoon; Fiscal Year: 2009
    ..We refer to these cells as BM-derived multipotent stem cells (BMSCs)...
  27. Origin and Fate of Myogenic Stem Cells
    Mindy George Weinstein; Fiscal Year: 2006
    ..become incorporated into organs lacking skeletal muscle during gastrulation, and (3) are able to induce multipotent stem cells to form muscle...
  28. Epithelial Cell Linage in the Kidney and Genitourinary Tract
    Peter Igarashi; Fiscal Year: 2007
    ..In the third aim, the origins of renal tubular epithelial cells will be examined using multipotent stem cells in which the Ksp-cadherin promoter directs expression of a GFP reporter gene...
  29. Investigating Novel Memory B Cell-Specific Genes Using Fluorescent Reporter Mice
    Mark Shlomchik; Fiscal Year: 2009
    ..interest because they are well-known to maintain homeostatic self-renewal capacity in pluripotent and multipotent stem cells. Our data, and that of others, is consistent with memory B cells having an extended half-life and ..
  30. REGULATION OF CSF PRODUCTION BY NORMAL HUMAN CELLS
    James Griffin; Fiscal Year: 1990
    ..A small number of self-renewing multipotent stem cells give rise to progenitor cells committed to single hematopoietic lineages...
  31. DIFFERENTIATION OF MEMORY B CELL PRECURSORS
    JOHN FIDLER; Fiscal Year: 1980
    ..Unprimed B lymphocytes are derived from virgin B cells which develop from multipotent stem cells. Memory B cells are generated as a result of antigenic stimulation...
  32. Multipotent Stem Cells in Post Natal Bone Marrow
    Catherine Verfaillie; Fiscal Year: 2006
    ..Whether this unexpected plasticity constitutes "transdifferentiation" or whether a small population of multipotent stem cells persists in post-natal tissues is not known The finding that stem cells exist in post-natal tissues with ..
  33. Biology and Molecular Regulation of Skin Stem Cells
    Isaac Brownell; Fiscal Year: 2010
    ..Recently, highly-plastic multipotent stem cells have been isolated from both the follicular epithelium and associated dermal stroma...
  34. MOLECULAR STUDIES OF HEMATOPOIETIC STEM CELLS
    Ihor Lemischka; Fiscal Year: 2009
    ..The origin of the hematopoietic hierarchy lies in a rare population of self-renewing multipotent stem cells. Much biological and physical information has been obtained which collectively describes hematopoietic ..
  35. Therapeutic Microvascular Pericytes
    SHAYN PEIRCE COTTLER; Fiscal Year: 2009
    ..New data suggests that human adipose tissue contains a sub-population of self-renewing, multipotent stem cells (hASCs) that possess vast differentiation potential and an ability to augment microvascular growth in vivo ..
  36. Osteogenic Potential of Human Bone Marrow Cells
    Michael Long; Fiscal Year: 2007
    ..The central hypothesis is that expression of osteogenic potential resides within a single population of multipotent stem cells that phenotypically differs depending upon its locale...
  37. Behavior and plasticity of grafted adult human neural stem cells in injured CNS
    Dong Sun; Fiscal Year: 2009
    ..Recent studies show that the mature mammalian CNS harbors multipotent stem cells capable of differentiation into neurons and glia in various regions...
  38. Pathogenesis of Laminin-alpha2 Deficiency
    Jeffrey Miller; Fiscal Year: 2005
    ..For Aim 3, we will determine if muscle stem cell function is altered in CMD 1. Postnatal muscle contains multipotent stem cells, but no studies have examined these recently identified stem cells in diseased muscle...
  39. Evaluation of Stem Cell Plasticity In Vivo
    Graca Almeida Porada; Fiscal Year: 2004
    ..a mixed population each member of which is committed to its own embryonic fate, or a pooi of truly multipotent stem cells exists within various tissues...
  40. Cranial Bone Repair with Adipose-Derived Stem Cells
    Roy Ogle; Fiscal Year: 2003
    ..The central hypothesis of this study is that ADASCs can be maintained as replicating multipotent stem cells, which can be induced to differentiate into osteoblasts in vitro and, when delivered appropriately, will ..
  41. Adult Multipotent Stem Cells from Rhesus Macaques
    TIMOTHY O BRIEN; Fiscal Year: 2003
    ..e., bone marrow-derived multipotent stem cells)...
  42. CHARACTERIZATION OF CNS STEM CELLS USING SOMATIC MOSAICS
    William Bowers; Fiscal Year: 2000
    The existence of multipotent stem cells in the primarily post-mitotic cellular environment of the adult brain has sparked intense research into identification of putative cell type(s) and potential functions...
  43. Initial Characterization of Pig Hemangioblasts
    Thomas Quertermous; Fiscal Year: 2002
    DESCRIPTION (Verbatim from the application): Multipotent stem cells exist in a variety of embryonic and post-embryonic tissues, and include neural and hematopoietic stem cells...
  44. Potential of Cord Blood Cells to Rescue Aging Brain
    Alison Willing; Fiscal Year: 2006
    ..The potential for therapeutic intervention with multipotent stem cells from adult tissues such as human umbilical cord blood (human UCB or HUCB) holds promise, yet has not been ..
  45. Expression Programs of Intestinal Cell Differentiation
    Xin Chen; Fiscal Year: 2006
    ..This self-renewal is maintained by a group of multipotent stem cells located at intestinal crypts...
  46. Regulation of Progenenitor Cell Maturation in the Cortex
    Laura Lillien; Fiscal Year: 2007
    ..The EGFR-hi subset is heterogeneous and includes multipotent stem cells. EGFR-hi cells have also been suggested as a source of gliomas...
  47. Identity and Function of CNS Progenitor Cell Genes
    Harley Kornblum; Fiscal Year: 2007
    ..with these constructs will be sorted using FACS and assayed for their ability to serve as self-renewing, multipotent stem cells. The hypothesis that MELK, TOPK and PSP regulate neural stem/progenitor self-renewal will be directly ..
  48. COMPARATIVE BIOLOGY OF HEMATOPOIETIC STEM CELLS
    David Scadden; Fiscal Year: 1999
    ..recently developed in vitro systems: (1) a directed suicide selection technique for enriching quiescent, multipotent stem cells, and (2) an in vitro T-lymphopoiesis model...
  49. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  50. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  51. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2008
    ..The results obtained from this research proposal will allow us to better understand not only normal hematopoiesis but also aberrant hemato/lymphopoiesis that can result in leukemia or immunodeficiency. ..
  52. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor, which drive specific steps in lymphocyte development, and to determine the genes involved in this process. ..
  53. Spiralian developmental system for the study of multipotency
    Cesar Arenas Mena; Fiscal Year: 2008
    ..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. Understanding the molecular mechanisms that control multipotency will greatly enhance future therapeutic ..
  54. 2008 Musculoskeletal Biology and Bioengineering Gordon Research Conference
    Farshid Guilak; Fiscal Year: 2008
    ..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
  55. 3D Woven Scaffolds for Tissue Engineering
    Farshid Guilak; Fiscal Year: 2003
    ..An improved level of biomechanical function will increase the level of success in the engineered repair of various tissues of the musculoskeletal system as well as other organ systems of the body. ..
  56. Training in Biomolecular and Tissue Engineering
    Farshid Guilak; Fiscal Year: 2007
    ..We will also take advantage of several long-standing and successful initiatives at Duke University to enhance the recruitment of underrepresented minorities as part of this post-doctoral training program. ..
  57. Neural Progenitor Cells as Cancer Therapy Vectors
    Karen Aboody; Fiscal Year: 2009
    ..The described approach might then be adapted to the treatment of other solid tumors by careful choice of appropriate therapeutic transgenes. ..
  58. Meeting: Development of the Spinal Cord and Neural Crest
    Marianne Bronner Fraser; Fiscal Year: 2002
    ....
  59. Conference on Stem Cells: Origins, Fate and Functions
    Fred Gage; Fiscal Year: 2002
    ..Evaluation of the current application of stem cells for diagnosis and therapy should provide a measure of how much progress has been made and is needed. ..
  60. Characterization of A Novel 65kDa E-selectin Ligand on G-CSF Mobilized Leukocytes
    Robert Sackstein; Fiscal Year: 2008
    ..It is anticipated that the results obtained will lead to new approaches for preventing or alleviating G-CSF-induced vascular and inflammatory complications [unreadable] [unreadable] [unreadable]..
  61. HAIR FOLLICLE BULGE CELLS IN TUMORIGENESIS AND ALOPECIA
    George Cotsarelis; Fiscal Year: 2009
    ..Patients with alopecia, hair shaft disorders, basal cell carcinoma, hair follicle tumors, or chronic wounds could potentially benefit from this research. ..
  62. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..