exocrine pancreas

Summary

Summary: The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.

Top Publications

  1. pmc Hedgehog signaling is required for effective regeneration of exocrine pancreas
    Volker Fendrich
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 135:621-31. 2008
  2. pmc Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    Akari Inada
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19915-9. 2008
  3. ncbi Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas
    Ilkka Ketola
    Children s Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, Room B525b, 00014 University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 226:51-7. 2004
  4. ncbi Ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells: role of fatty acid ethyl esters
    Hai Wu
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Alcohol Alcohol 43:1-8. 2008
  5. pmc Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicent
    S Desplat-Jego
    Laboratoire d Immunologie, CHU de la Conception, 147, Bd Baille, Marseille 13005, France
    World J Gastroenterol 13:2312-8. 2007
  6. ncbi Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter
    Haiyan Wan
    Department of Biological Sciences, National University of Singapore, Singapore
    Exp Cell Res 312:1526-39. 2006
  7. pmc Protein tyrosine phosphatase kappa and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas
    J Schnekenburger
    Department of Medicine B, Westfalische Wilhelms Universitat Munster, Germany
    Gut 54:1445-55. 2005
  8. ncbi Association of antibodies to exocrine pancreas with subtypes of Crohn's disease
    Frank H Klebl
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Gastroenterol Hepatol 17:73-7. 2005
  9. pmc Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish
    Zhi Jiang
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing, People s Republic of China
    PLoS Biol 6:e293. 2008
  10. ncbi IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108 0071, Japan
    Science 309:2232-4. 2005

Detail Information

Publications233 found, 100 shown here

  1. pmc Hedgehog signaling is required for effective regeneration of exocrine pancreas
    Volker Fendrich
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 135:621-31. 2008
    Although both endocrine and the exocrine pancreas display a significant capacity for tissue regeneration and renewal, the existence of progenitor cells in the adult pancreas remains uncertain...
  2. pmc Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    Akari Inada
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19915-9. 2008
    ..after replication undergo a regression to a less differentiated state and then can form new endocrine and exocrine pancreas. To directly test whether ductal cells serve as pancreatic progenitors after birth and give rise to new ..
  3. ncbi Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas
    Ilkka Ketola
    Children s Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, Room B525b, 00014 University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 226:51-7. 2004
    ..We conclude that GATA-4 is a marker of exocrine pancreatic differentiation, whereas GATA-6 is a marker of endocrine pancreatic development...
  4. ncbi Ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells: role of fatty acid ethyl esters
    Hai Wu
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Alcohol Alcohol 43:1-8. 2008
    ..To understand the mechanism(s) of alcoholic pancreatitis and role of fatty acid ethyl esters (FAEEs, non-oxidative metabolites of ethanol) in ethanol-induced pancreatic injury...
  5. pmc Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicent
    S Desplat-Jego
    Laboratoire d Immunologie, CHU de la Conception, 147, Bd Baille, Marseille 13005, France
    World J Gastroenterol 13:2312-8. 2007
    ..cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn's disease (CrD) and ulcerative colitis (UC)...
  6. ncbi Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter
    Haiyan Wan
    Department of Biological Sciences, National University of Singapore, Singapore
    Exp Cell Res 312:1526-39. 2006
    In contrast to what we know on development of endocrine pancreas, the formation of exocrine pancreas remains poorly understood...
  7. pmc Protein tyrosine phosphatase kappa and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas
    J Schnekenburger
    Department of Medicine B, Westfalische Wilhelms Universitat Munster, Germany
    Gut 54:1445-55. 2005
    ..We have previously shown that cell contacts between pancreatic acinar cells dissociate early in pancreatitis and that this is a prerequisite for the development of pancreatic oedema. Here we studied the underlying mechanism...
  8. ncbi Association of antibodies to exocrine pancreas with subtypes of Crohn's disease
    Frank H Klebl
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Gastroenterol Hepatol 17:73-7. 2005
    ..This study tested whether antibodies against exocrine pancreatic tissue (PAbs) are associated with Vienna classification subtypes of CD...
  9. pmc Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish
    Zhi Jiang
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing, People s Republic of China
    PLoS Biol 6:e293. 2008
    ..Conversely, overexpression of exdpf resulted in an overgrowth of the exocrine pancreas and a severe reduction of the endocrine cell mass, suggesting an inhibitory role for exdpf in endocrine cell ..
  10. ncbi IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108 0071, Japan
    Science 309:2232-4. 2005
    ..Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth...
  11. pmc PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion
    L Andy Chen
    Department of Surgery and Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    J Biol Chem 284:2459-71. 2009
    ..These findings reveal a novel distinction between the exocrine and endocrine cells of the pancreas and further identify PKD3 as a signaling molecule that promotes hormone-stimulated amylase secretion...
  12. ncbi Exocrine pancreas trans-differentiation to hepatocytes--a physiological response to elevated glucocorticoid in vivo
    Karen Wallace
    Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, UK
    J Steroid Biochem Mol Biol 116:76-85. 2009
    ..These data suggest that a pathological response of the pancreas in vivo to elevated glucocorticoid is a differentiation of exocrine pancreatic cells or pancreatic progenitor cells to an hepatocyte-like phenotype...
  13. ncbi Cystic neoplasms of the exocrine pancreas: an update of a nationwide survey in Korea
    Won Jae Yoon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Pancreas 37:254-8. 2008
    ..The purpose of this study was to update a previous study of cystic neoplasms of the pancreas (PCNs) conducted in Korea by the authors...
  14. ncbi ER-stress caused by accumulated intracistanal granules activates autophagy through a different signal pathway from unfolded protein response in exocrine pancreas cells of rats exposed to fluoride
    Mie Ito
    Laboratory of Toxicology, Course of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University, 1 1 Gakuen cho, Nakaku, Sakai 599 8531, Japan
    Arch Toxicol 83:151-9. 2009
    In rat exocrine pancreas cells, fluoride treatment causes autophagy resulting from intracisternal granule accumulation. Excessive autophagy might promote a type of programmed cell death different from apoptosis...
  15. ncbi The changing face of the exocrine pancreas in cystic fibrosis: the correlation between pancreatic status, pancreatitis and cystic fibrosis genotype
    Arie Augarten
    CF Center, Chaim Sheba Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Eur J Gastroenterol Hepatol 20:164-8. 2008
    ....
  16. pmc CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth
    Stephen J Crozier
    Department of 1Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1154-63. 2010
    ..Prolonged mTORC1 activation is thus required for dietary protein-induced pancreatic growth in the absence of CCK...
  17. pmc Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    Seung Woo Park
    Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 134:2080-90. 2008
    ..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos...
  18. ncbi Cystic neoplasms of the exocrine pancreas
    F Campbell
    Department of Pathology, Royal Liverpool University Hospital, Liverpool, UK
    Histopathology 52:539-51. 2008
    ..immunohistochemistry, molecular biology, pathogenesis and management of cystic neoplasms of the exocrine pancreas. These include the serous, the mucinous cystic, the intraductal papillary mucinous and the solid ..
  19. ncbi Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis
    Yuan Li
    Institute of Digestive Surgery, West China Hospital, Sichuan University Chengdu, Sichuan, China
    Pancreas 30:375-81. 2005
    ..To detect Toll-like receptor 4 (TLR4) expression and distribution in rat pancreas and the change of TLR4 expression in cerulein-induced pancreatitis (CIP)...
  20. ncbi The role of aquaporin water channels in fluid secretion by the exocrine pancreas
    B Burghardt
    Molecular Oral Biology Research Group, Department of Oral Biology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    J Membr Biol 210:143-53. 2006
    The mammalian exocrine pancreas secretes a near-isosmotic fluid over a wide osmolarity range. The role of aquaporin (AQP) water channels in this process is now becoming clearer...
  21. ncbi Ethanol impairs calcium homeostasis following CCK-8 stimulation in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Cell Physiology Research Group, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, PO Box 643, Caceres, Spain
    Alcohol 42:565-73. 2008
    ..The actions of ethanol on CCK-8 stimulation of cells create a situation potentially leading to Ca2+ overload, which is a common pathological precursor that mediates pancreatitis...
  22. ncbi Origin of the zebrafish endocrine and exocrine pancreas
    Andrea B Ward
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60615, USA
    Dev Dyn 236:1558-69. 2007
    ..Endocrine vs. exocrine pancreas show a similar pattern of progenitors, consistent with descriptions of the dorsal bud being strictly ..
  23. ncbi Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells
    Z Landau
    Ben Gurion University of the Negev, Beer Sheva, 84105, Israel
    Apoptosis 11:717-24. 2006
    ..The influence of fat overflow on the exocrine pancreas is not known...
  24. pmc Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation
    Bihui Zhong
    Department of Medicine, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA 94304, USA
    Mol Biol Cell 18:4969-78. 2007
    ..Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and ..
  25. pmc Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process
    J Matthias Lohr
    Molecular Gastroenterology, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 105:2060-71. 2010
    ..The objective was to identify novel markers of disease and to unravel the pathogenesis of AIP...
  26. ncbi Fecal chymotrypsin and elastase-1 determination on one single stool collected at random: diagnostic value for exocrine pancreatic status
    Isabelle Molinari
    Biochemistry Laboratory, Hopital Pellegrin, Bordeaux, France
    Clin Biochem 37:758-63. 2004
    ..The aim of our study was to investigate the diagnostic advantage from measuring fecal proteases in stool samples collected for two or three consecutive days in comparison to one single stool sample collected at random...
  27. pmc Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion
    Vijay P Singh
    Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
    Gut 56:958-64. 2007
    ..However, the mechanism by which it protects against pancreatitis still remains to be elucidated. Acute pancreatitis is associated with premature zymogen activation and a blockage in digestive enzyme secretion...
  28. ncbi Ethanol induces secretion of oxidized proteins by pancreatic acinar cells
    V O Palmieri
    Section of Internal Medicine, Department of Internal and Public Medicine DIMIMP, University Medical School of Bari, Bari, Italy
    Cell Biol Toxicol 23:459-64. 2007
    ..These findings may account for the decreased exocrine function, intraductular plug formation, and protein precipitation in alcoholic pancreatitis...
  29. ncbi Hypoplasia of endocrine and exocrine pancreas in homozygous transgenic TGF-beta1
    Maki Moritani
    Institute for Genome Research, Division of Genetic Information, The University of Tokushima, Tokushima 770 8503, Japan
    Mol Cell Endocrinol 229:175-84. 2005
    ..endocrine and exocrine pancreatic hypoplasia, second that TGF-beta1decrease the final size of endocrine and exocrine pancreas presumably through regulating cell cycle via p15(INK4b) at least in endocrine pancreas, and third that ..
  30. ncbi An illustrated review of early pancreas development in the mouse
    Mette Christine Jørgensen
    Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK 2820 Gentofte, Denmark
    Endocr Rev 28:685-705. 2007
    ..We further discuss how this global analysis of the developing pancreas confirms and extends previous studies, and we envisage that this type of analysis can be instrumental for evaluating mutant phenotypes in the future...
  31. ncbi Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction
    Tino Klein
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Pancreas 38:36-48. 2009
    We aimed to characterize a serum-free culture system resulting in highly enriched duct cells from human exocrine pancreas. In addition, we tested the effect of vascular endothelial growth factor (VEGF) on endothelial cell proliferation ..
  32. ncbi Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development
    Reto M Baertschiger
    Department of Surgery, Surgical Research Unit, University Hospital Geneva, Geneva, Switzerland
    Pancreas 37:75-84. 2008
    ..The aim of this study was to isolate, expand, and characterize cells from human exocrine pancreas and analyze their potential to differentiate into beta cells.
  33. ncbi Exocrine meets endocrine: pancreatic stone protein and regenerating protein--two sides of the same coin
    Rolf Graf
    Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    J Surg Res 133:113-20. 2006
    ..Regenerating protein (reg) and pancreatic stone protein (PSP) have been discovered independently in the fields of diabetes and pancreatitis...
  34. ncbi The changing face of the exocrine pancreas in cystic fibrosis: pancreatic sufficiency, pancreatitis and genotype
    Jarosław Walkowiak
    Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
    Eur J Gastroenterol Hepatol 20:157-60. 2008
    ..Potential appearance of this complication in individuals with pancreatic insufficiency demands elucidation...
  35. pmc PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
    Kaori Iida
    Department of History of Science and Technology, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Cell Biol 8:38. 2007
    ..To determine if the exocrine pancreatic atrophy is due to a cell-autonomous defect, the Perk gene was specifically ablated in acinar cells of the exocrine pancreas in mice.
  36. ncbi Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation
    Hana Algül
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Int J Cancer 121:1410-6. 2007
    ..In this study, the role of ErbB2 in the exocrine pancreas was examined by ectopic overexpression under the control of the proximal rat elastase promoter...
  37. ncbi Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells
    David Stafford
    The Committee on Developmental Biology, The University of Chicago, 1027 East 57th Street, IL 60637, USA
    Development 133:949-56. 2006
    ..These findings suggest that RA will have important applications in the quest to induce islets from stem cells for therapeutic uses...
  38. ncbi Secretion from acinar cells of the exocrine pancreas: role of enteropancreatic reflexes and cholecystokinin
    Manfred V Singer
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Cell Biol Int 33:1-9. 2009
    Although the molecular machinery and mechanism of cell secretion in acinar cells of the exocrine pancreas is well documented and clear, only recently has the pharmacophysiology of pancreatic exocrine secretion come to light...
  39. pmc Wnt/beta-catenin signaling is required for development of the exocrine pancreas
    James M Wells
    Department of Developmental Biology, Cincinnati Children s Hospital Research 45267, Cincinnati, OH 45267, USA
    BMC Dev Biol 7:4. 2007
    ..A Pdx1-cre mouse line was used to delete a floxed beta-catenin allele specifically in the developing pancreas, and embryonic pancreata were studied by immunohistochemistry and microarray analysis...
  40. ncbi Proteomic of lipid rafts in the exocrine pancreas from diet-induced obese rats
    Amine Adda Berkane
    Universite Paul Cezanne, FST Institut Méditerranéen de Recherche en Nutrition IMRN, UMR INRA 1111 PNV UMR 6153 1147, Marseille, France
    Biochem Biophys Res Commun 355:813-9. 2007
    In the present work, we induced obesity in rats with high-energy-starch diet and studied exocrine pancreas response...
  41. ncbi Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors
    Julia V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX United Kingdom
    J Biol Chem 281:40154-63. 2006
    ..Bile acid-elicited intracellular Ca(2+) liberation from both the ER and the apical acidic stores depends on both RyRs and IP(3)Rs...
  42. ncbi Can beta-cells be derived from exocrine pancreas?
    L Baeyens
    Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel Free University of Brussels, Brussels, Belgium
    Diabetes Obes Metab 10:170-8. 2008
    ..It will now be important to translate these findings to human cells...
  43. ncbi Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis
    Agnes S Kowalik
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G1123-32. 2007
    ..the Mist1 gene [Mist1 knockout (KO) mice] exhibit cellular disorganization and functional defects in the exocrine pancreas but no gross morphological defects...
  44. pmc All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas
    Chia Ning Shen
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Differentiation 75:62-74. 2007
    ....
  45. ncbi Conditional inactivation of Myc impairs development of the exocrine pancreas
    Hassan Nakhai
    Department of Internal Medicine, Technical University of Munich, Munich, Germany
    Development 135:3191-6. 2008
    Recent studies have shown that Wnt/beta-catenin signaling is essential for development of the exocrine pancreas, but the role of beta-catenin-dependent target genes such as Myc during pancreatic development is not well known...
  46. ncbi Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland
    James L McManaman
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center at Fitzsimons, Mail Stop 8309, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 11:249-68. 2006
    ..Comparisons of current secretion and transport models in the mammary gland, exocrine pancreas and salivary gland indicate that significant differences exist between the mammary gland and other exocrine ..
  47. ncbi Interactions between the endocrine and exocrine pancreas and their clinical relevance
    Laszlo Czako
    First Department of Medicine, University of Szeged, Szeged, Hungary
    Pancreatology 9:351-9. 2009
    ..This may improve the nutritional condition of the patient and decrease the metabolic instability...
  48. ncbi Giessen international workshop on interactions of exocrine and endocrine pancreatic diseases. Castle of Rauischholzhausen of the Justus-Liebig-University, Giessen, Germany. March 18-19, 2005
    Ake Andren-Sandberg
    Department of Gastrointestinal Surgery, Sntralsjukehuset i Rogaland, Bergen University, Stavanger, Norway
    JOP 6:382-405. 2005
    ..The meeting resulted in more cooperation and a number of new concepts for clinical study which will provide data for future developments...
  49. ncbi The outcome of a long-term follow-up of pancreatic function after recovery from acute pancreatitis
    Tomas Symersky
    Department of Gastroenterology Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    JOP 7:447-53. 2006
    ..It is generally assumed that pancreatic function recovers completely after mild but not after severe acute pancreatitis...
  50. ncbi Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells
    L Fischer
    Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Veterans Affairs Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 292:G875-86. 2007
    ..The findings have important implications for the mechanism of acute pancreatitis since [Ca(2+)](i) increases and trypsinogen activation mediate key pathological processes in this disorder...
  51. ncbi Evaluation of two novel peptide safety markers for exocrine pancreatic toxicity
    Jennie L Walgren
    Pfizer Global Research and Development, Drug Safety Research and Development, Chesterfield, Missouri 63017, USA
    Toxicol Sci 96:184-93. 2007
    ..In conclusion, the RA1609 and RT2864 peptides are sensitive indicators of exocrine pancreatic damage that may be useful as safety markers for general pancreatic toxicity in multiple species...
  52. pmc Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats
    You Dai Chen
    Instistute of Digestive Surgery Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:538-44. 2005
    ..We investigated the actions of PACAP and its receptor antagonists in acute pancreatitis on rats...
  53. ncbi Tubular complexes as a source for islet neogenesis in the pancreas of diabetes-prone BB rats
    Gen Sheng Wang
    The Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Lab Invest 85:675-88. 2005
    ..5. This study demonstrates that TC are upregulated during beta-cell destruction and contain potential endocrine progenitors...
  54. ncbi Identification of novel peptide safety markers for exocrine pancreatic toxicity induced by cyanohydroxybutene
    Jennie L Walgren
    Pfizer Global Research and Development, Drug Safety Research and Development, Chesterfield, Missouri 63017, USA
    Toxicol Sci 96:174-83. 2007
    ....
  55. ncbi Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    Jan Nygaard Jensen
    Barbara Davis Center for Childhood Diabetes, U Colorado, HSC, 4200 E 9th Avenue, B140, Denver, Colorado 80262 USA
    Gastroenterology 128:728-41. 2005
    ..To define cell differentiation changes associated with pancreatic regeneration in adult mice, we compared regeneration following caerulein-induced pancreatitis to that of normal pancreatic development...
  56. ncbi Role of FGF1, FGF2 and FGF7 in the development of the pancreas from control and streptozotocin-treated hamsters
    M Inchovska
    Bulgarian Academy of Sciences IEMA, G Bonchev str Bl 25, Sofia, Bulgaria
    Cell Prolif 39:537-50. 2006
    ..Taken together these data strongly suggest that FGF1 and FGF2 induce proliferation of pancreatic epithelial cells during the early post-natal period whereas FGF7 is not strictly specific for pancreatic cell proliferation...
  57. ncbi Response of the exocrine pancreas to the CCK on offspring rats of ethanol dams. Effects of folic acid
    M J Cano
    Department of Physiology and Zoology, Pharmacy Faculty, School of Pharmacy, University of Seville, c Tramontana s n 41012 Seville, Spain
    Alcohol Alcohol 42:277-84. 2007
    ....
  58. ncbi Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis
    Francisco Miralles
    Département de Génétique et Développement, Institut Cochin, INSERM U567, CNRS UMR8104, Universite Rene Descartes Paris V, Paris, France
    Lab Invest 86:1020-36. 2006
    ..However, after weaning, these mice developed profound morphological alterations of the exocrine pancreas, which were reminiscent of severe pancreatitis...
  59. ncbi Effect of jejunal nutrition on pancreatic exocrine secretion in pancreatitis rats and the involvement of the nucleus tractus solitarius
    Hang Zhao
    Changhai Hospital, Department of Gastroenterology, Second Military Medical University, 174 Chang Hai Road, Shanghai 200433, China
    Auton Neurosci 124:90-5. 2006
    ..It is likely that the central integration mechanism, pathway of vagal efferent nerve or status of effector in acute pancreatitis may be different from normal physiological conditions...
  60. ncbi Effects of high dose retinoic acid on TGF-beta2 expression during pancreatic organogenesis
    Neriman Colakoglu
    Histology and Embryology Department, Medical Faculty, Firat University, Elazig, Turkey
    J Mol Histol 36:413-8. 2005
    ..However, its administration after neurulation had less adverse affect on pancreatic organogenesis and TGF-beta2 immune reactivity...
  61. ncbi Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1
    S Chen
    Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Baylor Heart and Vascular Institute, Dallas, TX 75226, USA
    Gene Ther 14:1102-10. 2007
    ..These cells co-expressed amylase and insulin and demonstrated several beta-cell markers by reverse transcription-PCR. Gene therapy by UTMD can reverse diabetes in vivo in adult rats by restoring pancreatic insulin production...
  62. ncbi Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells
    Constanze H Kubisch
    The Univ of Texas M D Anderson Cancer Center, Dept of Cancer Biology, Unit 0953, SCRB2 2021, 7435 Fannin St, PO Box 301429, Houston, TX 77230 1429, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1804-12. 2007
    ..In conclusion, ER stress response mechanisms appear to be involved in both pancreatic physiology and pathophysiology, and future efforts should be directed at understanding the roles of these mechanisms in the pancreas...
  63. ncbi Presence of endocrine and exocrine markers in EGFP-positive cells from the developing pancreas of a nestin/EGFP mouse
    Andreia S Bernardo
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Cell Endocrinol 253:14-21. 2006
    ..These results support the conclusion that nestin expressing cells can give rise to both endocrine and exocrine cells. The ability to purify these putative progenitor cells may provide further insights into their properties and function...
  64. ncbi Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism
    J A Tapia
    Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1763:25-38. 2006
    ..Our results give reasons for a more careful choice of rottlerin for PKC-delta investigation...
  65. pmc Embryonic pig pancreatic tissue transplantation for the treatment of diabetes
    Smadar Eventov-Friedman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 3:e215. 2006
    ..In the present study we examined growth potential, functionality, and immunogenicity of pig embryonic pancreatic tissue harvested at different gestational ages...
  66. pmc Zymogen activation in a reconstituted pancreatic acinar cell system
    Edwin C Thrower
    Veterans Administration Medical Center, Bldg 27, 950 Campbell Avenue, West Haven, CT 06516, USA
    Am J Physiol Gastrointest Liver Physiol 290:G894-902. 2006
    ..A component of the activation of some zymogens, such as chymotrypsinogen and procarboxypeptidase, may depend on ATP but not on trypsin or cathepsin B...
  67. ncbi Haemodynamic and exocrine effects of caerulein at submaximal and supramaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes
    Thomas Griesbacher
    Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Pancreatology 6:65-75; discussion 75-6. 2006
    ..We have investigated the involvement of cholecystokinin (CCK) receptor subtypes in haemodynamic changes in the pancreas of anaesthetized rats during submaximal and supramaximal stimulation with the CCK analogue, caerulein...
  68. ncbi Cholecystokinin stimulates the recruitment of the Src-RhoA-phosphoinositide 3-kinase pathway by Vav-2 downstream of G(alpha13) in pancreatic acini
    Minil Kim
    Second Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai Shinagawa ku, Tokyo 142 8666, Japan
    Biochem Biophys Res Commun 339:271-6. 2006
    ..CCK also enhanced Vav-2 and RhoA to coimmunoprecipitate with G(alpha13). We conclude that CCK stimulates the recruitment of the Src-RhoA-PI3-K signaling pathway by Vav-2 downstream of G(alpha13) in pancreatic acini...
  69. ncbi Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin
    Maria Dolors Sans
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Nutr 136:1792-9. 2006
    ..We conclude that leucine may participate, as a signal as well as a substrate, in activating the translational machinery in pancreatic acinar cells independently of hormonal effects and that this action is through the mTOR pathway...
  70. ncbi Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c
    Laura I Cosen-Binker
    Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 282:13047-58. 2007
    The pancreatic acinus is the functional unit of the exocrine pancreas whose role is to secrete zymogens into the gut lumen for food digestion via apical exocytosis...
  71. pmc The ryanodine receptor mediates early zymogen activation in pancreatitis
    Sohail Z Husain
    Department of Pediatrics, Yale University School of Medicine and Veterans Affairs Connecticut Health Care, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:14386-91. 2005
    ..Inhibition of RYR also inhibited zymogen activation in vivo. We propose that Ca(2+) release from the RYR mediates zymogen activation but not enzyme secretion. The findings imply a role for the RYR in acute pancreatitis...
  72. ncbi Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells
    Ramasamy Tamizhselvi
    Department of Pharmacology, National University of Singapore, Yong Loo Lin School of Medicine, Centre for the Sciences, 28 Medical Drive, Singapore 117456
    J Cell Mol Med 11:315-26. 2007
    ..These results suggest that the pro-inflammatory effect of H(2)S may be mediated by SP-NK-1R related pathway in mouse pancreatic acinar cells...
  73. ncbi Duct ligation and pancreatic islet blood flow in rats: physiological growth of islets does not affect islet blood perfusion
    Leif Jansson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Eur J Endocrinol 153:345-51. 2005
    ..The aim of this study was to evaluate islet blood-flow changes during stimulated growth of the islet organ without any associated functional impairment of islet function...
  74. ncbi Oxidant-impaired intracellular Ca2+ signaling in pancreatic acinar cells: role of the plasma membrane Ca2+-ATPase
    Jason I E Bruce
    Faculty of Life Sciences, 2nd Floor Core Technology Facility, 46 Grafton St, The Univ of Manchester, Manchester M13 9NT, UK
    Am J Physiol Cell Physiol 293:C938-50. 2007
    ..1-1 mM) inactivated the plasma membrane Ca(2+)-ATPase. This may be important in facilitating "Ca(2+) overload," resulting in cell injury associated with pancreatitis...
  75. ncbi Nestin-positive cells in adult pancreas express amylase and endocrine precursor Cells
    Hiroyuki Ueno
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Pancreas 31:126-31. 2005
    ..These findings demonstrate that nestin-positive cells comprise a portion of pancreatic exocrine cells and suggest that they can be differentiated into pancreatic endocrine cells...
  76. ncbi Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice
    Qihong Zhang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Lab Invest 85:45-64. 2005
    ..These findings are interesting in light of the recently proposed role for polaris, the protein encoded by the Tg737 gene, in the hedgehog pathway and hedgehog signaling in insulin production and glucose homeostasis...
  77. ncbi Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin
    Sohail Z Husain
    Dept of Pediatrics, 333 Cedar St, FMP408, PO Box 208064, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1594-9. 2007
    ..These findings suggest that calcineurin mediates caerulein-induced intra-acinar zymogen activation but not enzyme secretion or the initial caerulein-induced cytosolic Ca(2+) signal...
  78. ncbi Notch signaling is required for exocrine regeneration after acute pancreatitis
    Jens T Siveke
    Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munchen, Germany
    Gastroenterology 134:544-55. 2008
    ..To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling in cerulein-induced pancreatitis in mice...
  79. pmc Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors
    Cécile Haumaitre
    INSERM U845, Centre de Recherche Croissance et Signalisation, Universite Paris Descartes, Faculte de Medecine, Hopital Necker, Paris, France
    Mol Cell Biol 28:6373-83. 2008
    ..They show the powerful use of HDACi to switch pancreatic cell determination and amplify specific cellular subtypes, with potential applications in cell replacement therapies in diabetes...
  80. pmc Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells
    Vijay P Singh
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 19:2339-47. 2008
    ..In addition, they suggest a potential use for Src inhibitors as an approach to reduce cell injury...
  81. ncbi Selective expansion of the beta-cell compartment in the pancreas of keratinocyte growth factor transgenic mice
    Martin Wagner
    Department of Internal Medicine I, University Ulm, Germany
    Am J Physiol Gastrointest Liver Physiol 294:G1139-47. 2008
    ..Furthermore, the observed phenotype demonstrates that an increase in the beta-cell compartment does not necessarily result in an improved glucose tolerance in vivo...
  82. ncbi Immunogold labeling of cryosections from high-pressure frozen cells
    Elly van Donselaar
    Department of Cell Biology, Institute of Biomembranes, University Medical Centre Utrecht, The Netherlands
    Traffic 8:471-85. 2007
    ..cryosections from high-pressure frozen cells (HepG2 cells, primary chondrocytes) and tissues (cartilage and exocrine pancreas)...
  83. ncbi Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models
    H Nakamura
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku Kitakyushu 807 8555, Japan
    Gut 57:788-98. 2008
    ..Smad6 is implicated in the inhibition of bone morphogenetic protein signalling. However, the function of Smad6 in the pancreas remains obscure...
  84. pmc Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells
    Daisuke Hashimoto
    Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Cell Biol 181:1065-72. 2008
    ..These results suggest that autophagy exerts devastating effects in pancreatic acinar cells by activation of trypsinogen to trypsin in the early stage of acute pancreatitis through delivering trypsinogen to the lysosome...
  85. ncbi Collagenase penetrates human pancreatic islets following standard intraductal administration
    Sarah E Cross
    Nuffield Department of Surgery, Islet Transplant Research Group, University of Oxford, Oxford, United Kingdom
    Transplantation 86:907-11. 2008
    ..The aim of this study was to characterize collagenase distribution in relation to islets in infused human pancreases...
  86. ncbi C-type natriuretic peptide stimulates pancreatic exocrine secretion in the rat: role of vagal afferent and efferent pathways
    Maria E Sabbatini
    Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Eur J Pharmacol 577:192-202. 2007
    ..Present results suggest that CNP may play a role as a local regulator of the exocrine pancreas.
  87. ncbi Pancreatic duct after pancreatoduodenectomy: morphologic and functional evaluation with secretin-stimulated MR pancreatography
    Josep Monill
    Department of Radiology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Sant Antoni M Claret 167, Barcelona 08025, Spain
    AJR Am J Roentgenol 183:1267-74. 2004
    ..The purpose of this study was to evaluate the usefulness of secretin-enhanced MR pancreatography in evaluating morphologic changes and pancreatic function after pancreatoduodenectomy...
  88. ncbi JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells
    E Gallmeier
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Cell Physiol 203:209-16. 2005
    ..Besides stimulating immune cells via cytokine secretion, acinar cells are in turn capable of responding to IFN-gamma via JAK2 and STAT1 which may have an impact on the development of AP...
  89. ncbi Influence of an intravenous infusion of amino acids and glucose on the pancreatic exocrine in rats
    Bo Guang Fan
    Center for Gastrointestinal Disease, Taizhou Hospital, Wenzhou Medical College, Taizhou 318000, China
    Chin Med J (Engl) 117:1659-64. 2004
    ..investigations have pointed out that total parenteral nutrition (TPN) suppresses the function of the exocrine pancreas. Even though pancreatic hypotrophy and dysfunction resulting from TPN may be explained by several mechanisms,..
  90. ncbi In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes
    Francis J Descamps
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroederstraat 10, B 3000 Leuven, Belgium
    J Pathol 204:555-61. 2004
    ..In conclusion, gelatinase B itself is not a causative factor but, when activated by endogenous trypsin, is a permissive factor for insulin degradation and diabetes...
  91. ncbi The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas
    Kit Ching Lai
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Pancreas 35:e1-8. 2007
    ..This ghrelin system may play a role in regulating insulin secretion and glucose homeostasis. The aim of the present study was to investigate whether a functional ghrelin system also exists in the exocrine pancreas.
  92. pmc Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell
    A Chaudhuri
    Gastrointestinal Research Laboratory, Veterans Affairs Healthcare Connecticut, West Haven, CT 06516, USA
    Am J Physiol Gastrointest Liver Physiol 288:G235-43. 2005
    ..This study demonstrates that increasing acinar cell cAMP can overcome the inhibition of enzyme secretion caused by high concentrations of carbachol and eliminate acinar cell injury...
  93. ncbi Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes
    L Rossi
    University Hospital, Department of Medicine, Basel, Switzerland
    Pancreatology 4:461-7. 2004
    ..Testing pancreatic function, we investigated whether selective beta-cell impairment triggers diabetes associated with tropical pancreatitis...
  94. ncbi Disruption of paracellular sealing is an early event in acute caerulein-pancreatitis
    Marcus Schmitt
    Clinic for Gastroenterology, Hepatology, and Infectiology Universitätsklinikum Düsseldorf, Heinrich Heine Universität Düssseldorf, Germany
    Pancreas 28:181-90. 2004
    ....
  95. ncbi Macroamylasemia attributable to gluten-related amylase autoantibodies: a case report
    G Barera
    Department of Pediatrics, Scientific Institute H San Raffaele, University of Milan, Milan, Italy
    Pediatrics 107:E93. 2001
    ..We report a girl with CD, autoimmune thyroiditis, and MA, in whom CD-related antibodies to amylase and to exocrine pancreas tissue resolved with a gluten-free diet.
  96. ncbi The role of lipid antigen presentation, cytokine balance, and major histocompatibility complex in a novel murine model of adoptive transfer of insulitis
    L Ylinen
    Department of Pediatrics, University of Turku, Finland
    Pancreas 20:197-205. 2000
    ..IL-10 was expressed in almost all the animals: in exocrine pancreas, large groups of infiltrating lymphocytes, endothelia of blood vessels, pancreatic islets, and interstitial ..
  97. pmc Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro
    I H Waschulewski
    Department of Pharmacology, University of Cambridge, Germany
    Br J Pharmacol 108:892-900. 1993
    ..the immunosuppressive drugs cyclosporin A (CsA) and FK 506 on exocytosis in two in vitro preparations of the exocrine pancreas-lobules and dispersed acini. 2...
  98. ncbi Serological differentiation of inflammatory bowel diseases
    Karsten Conrad
    Institute of Immunology, Medical Faculty of the Technical University Dresden, Germany
    Eur J Gastroenterol Hepatol 14:129-35. 2002
    ..value of a newly developed assay for the determination of antibodies to mannan of Saccharomyces cerevisiae in combination with antibodies to antigens of exocrine pancreas, goblet cells, human neutrophils and tissue transglutaminase.
  99. ncbi Beer but not wine, hard liquors, or pure ethanol stimulates amylase secretion of rat pancreatic acinar cells in vitro
    Andreas Gerloff
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Alcohol Clin Exp Res 33:1545-54. 2009
    In contrast to pure ethanol, the effect of alcoholic beverages on the exocrine pancreas is greatly unknown...
  100. ncbi A co-localization study on the ovine pancreas innervation
    Marcin Bartłomiej Arciszewski
    Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, Agricultural University, Akademicka 12, 20 033 Lublin, Poland
    Ann Anat 189:157-67. 2007
    ..Single SP-immunoreactive (IR) nerve fibers of the exocrine pancreas and interlobular connective tissue as well as SP-positive intrapancreatic neurons additionally showed the ..
  101. ncbi Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas
    B R Douglas
    Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands
    Cancer Res 49:2438-41. 1989
    ..such as camostate is a well-established method for promoting growth of (pre)neoplastic foci induced in the exocrine pancreas of rats by azaserine...

Research Grants62

  1. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Chronic pancreatitis is a serious and painful disorder of exocrine pancreas with no effective therapeutic measures...
  2. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2012
    ..metabolic processes are connected by the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in kidney and intestinal mucosa in lower amounts...
  3. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..Enteral exclusion of bile-pancreatic juice by the stone causes feedback hyperstimulation of the exocrine pancreas that induces pancreatic overproduction of acute inflammatory mediators...
  4. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..transporter-2 in pancreatic beta cells and in sympathetic nerve terminals that innervate islets and exocrine pancreas, was targeted using the specific radioligand 11C-DTBZ...
  5. Early Pathogenesis of Cystic Fibrosis Related Diabetes
    Andrew W Norris; Fiscal Year: 2013
    ..Bet-cell in CF, with a focus on (i) CFTR-dependent intrinsic functions within the islet, (ii) CFTR-dependent exocrine pancreas contributions to islet dysfunction, and (iii) CFTR-dependent alterations in the intestine that influence ..
  6. Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ..Given the close relationship between the endocrine and exocrine pancreas, a unique feature of the pancreatic microenvironment is the potential influence of locally produced insulin ..
  7. Pancreas Transcription Factors and Disease Model Systems
    Stephen F Konieczny; Fiscal Year: 2013
    ..pancreatic cell function lead to several critical human diseases, including diabetes and two diseases of the exocrine pancreas - pancreatitis and pancreatic cancer...
  8. Alcohol abuse and Endoplasmic Reticulum dysfunction in exocrine pancreas
    Aurelia Lugea; Fiscal Year: 2013
    ..Alcohol is known to alter metabolism and function in distinct subcellular compartments. The exocrine pancreas has the most extensive endoplasmic reticulum (ER) system of any tissue, in order to maintain a high rate of ..
  9. Phytochemicals &Metabolism in Pancreatic Diseases/Pandol, Stephen
    Vay Liang W Go; Fiscal Year: 2011
    ..to design experiments to test the phytochemicals for prevention and/or treatment of the two disorders of the exocrine pancreas involving proliferative disorders of stellate and cancer cells-chronic pancreatitis and pancreatic cancer ..
  10. Apoptosis and Necrosis in Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2012
    ..leads to impaired autophagy and massive accumulation of autophagic vacuoles, especially in the heart and exocrine pancreas. LAMPs are glycoproteins, and they become unstable and rapidly degraded if underglycosylated...
  11. Mitochondrial Dysfunction, Permeability Transition Pore, and Acute Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2013
    ..Aims: Acute pancreatitis is a potentially fatal disease of exocrine pancreas, the pathogenesis of which remains obscure and specific treatments for which do not exist...
  12. Dissecting stromal-epithelial interactions in the adult exocrine pancreas
    Andrew D Rhim; Fiscal Year: 2013
    ..Through understanding how these cells cooperate, we hope to shed new light on the development of new ways of diagnosing and treating these diseases. ..
  13. Deciphering the Tissue Specificity of MEN1 Related Tumorigenesis
    STEVEN KENNETH LIBUTTI; Fiscal Year: 2013
    ..Specifically, we will compare tissues from the endocrine pancreas (develops tumors) versus the exocrine pancreas (does not develop tumors)...
  14. Lysosomal Damage, Impaired Autophagy, and Alcoholic Pancreatitis
    Olga A Mareninova; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pancreatitis is a potentially fatal disease of exocrine pancreas the pathogenesis of which remains obscure and for which no specific treatment has been developed...
  15. The role of cigarette smoke toxin and alcohol in pancreatitis
    Edwin C Thrower; Fiscal Year: 2013
    ..Although the harmful effects of combining smoking and alcohol on the exocrine pancreas have been established clinically, the cellular mechanisms underlying these responses are unknown...
  16. HUMAN ISLET ANTGEN DISCOVERY AND IMAGING
    Paul E Harris; Fiscal Year: 2012
    ..VMAT2 is highly expressed in beta cells of the human pancreas relative to other cells of the endocrine and exocrine pancreas. Thus dynamic measurements of the uptake and clearance of DTBZ radioligands in the pancreas provide a ..
  17. Physiology and pathophysiology of human pancreatic acinar cells
    Ashok K Saluja; Fiscal Year: 2013
    ..centers in the US, and to successfully harvest and study human acini in-vitro requires an experienced exocrine pancreas lab. At our center we are uniquely poised to fulfill both pre-requisites...
  18. Regulation of exocrine pancreas formation
    Lori Sussel; Fiscal Year: 2013
    ..and development have been characterized, little is known about the specification and development of the exocrine pancreas. In the studies proposed here, we will investigate the roles of two Gata factor family members, Gata4 and ..
  19. Genetic modifiers of diabetes in cystic fibrosis
    Scott M Blackman; Fiscal Year: 2013
    ..Cystic fibrosis (CF) is a genetic disease involving the exocrine pancreas in which patients develop diabetes at a high rate as they reach adolescence and young adulthood...
  20. Pancreatic Function: G-Protein Mediated Ca2+ Signaling
    David I Yule; Fiscal Year: 2012
    ..secretagogue stimulation plays a fundamental role in underlying digestive enzyme secretion from the exocrine pancreas. The increase in [Ca2+]i is a tightly regulated event and exhibits characteristic temporal and spatial ..
  21. The role of Pcif1 in pancreas development
    JEFFREY CHARLES RAUM; Fiscal Year: 2012
    ..of our Pcif1 null and Cre inducible Pcif1 mouse lines to define the contribution of Pcif1 function in the exocrine pancreas. Specifically, we will assess the role in acinar cell formation by quantifying cell numbers and the levels ..
  22. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..These studies should render support for the association between inositol phospholipid breakdown mediated by PLC and PLA2, CA2+ metabolism, protein phosphorylation, and amylase secretion...
  23. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael S German; Fiscal Year: 2013
    ..These studies will help explain how the differentiated state is established and maintained. Ultimately this information will help guide efforts to generate beta-cells for patients with diabetes. ..
  24. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2009
    ..These studies will help explain how the differentiated state is established and maintained. Ultimately this information will help guide efforts to generate beta-cells for patients with diabetes. ..
  25. Implementation of a pancreas knowledgebase
    John A Williams; Fiscal Year: 2013
    ..This proposal requests support to construct and implement an electronic resource for information on the exocrine pancreas. This pancreas knowledge base will be called "The Pancreapedia"...
  26. Transcriptional Regulators of Exocrine Pancreatic Development
    Raymond J Macdonald; Fiscal Year: 2013
    ..By understanding the control of normal development of the exocrine pancreas we hope to contribute to therapies that may help a pancreas badly damaged by pancreatitis to regenerate, or ..
  27. HETEROTRIMERIC G PROTEINS AND EXOCYTOSIS
    BHANU JENA; Fiscal Year: 1999
    ..of both monomeric as well as heterotrimeric G- proteins with zymogen granule membranes (ZGM) from rat exocrine pancreas. Our studies demonstrates the involvement of one of the rab's (rab3) in regulated exocytosis from exocrine ..
  28. A new curcumin analogue with potent suppressive activity in pancreatic cancer
    Jiayuh Lin; Fiscal Year: 2010
    ..Cancer of the exocrine pancreas is rarely curable and has an overall survival rate of less than 4%. The...
  29. Fibroblast Growth Factor Regulation in the Pancreas
    Sam Holmstrom; Fiscal Year: 2009
    ..Abnormalities in exocrine pancreas function can lead to serious conditions such as pancreatitis and pancreatic cancer...
  30. PROTEIN KINASE C MEDIATION OF EXOCRINE PANCREATIC SECRET
    Dexter Louie; Fiscal Year: 1992
    In the exocrine pancreas the major intracellular transduction pathway for hormone and neurotransmitter stimulated enzyme secretion is the calcium-phosphatidylinositol (PI) system...
  31. SURGICAL STUDIES ON METABOLISM OF GI HORMONES
    Guillermo Gomez; Fiscal Year: 2003
    ..today is to gain a better understanding of the underlying molecular mechanisms for maintenance of the exocrine pancreas and small bowel mucosa. Acute pancreatitis (AP) is a complex and poorly understood disease...
  32. BILE SECRETION AND INTRACELLULAR CA2+ SIGNALS
    Michael Nathanson; Fiscal Year: 1999
    ..for understanding secretion in other organs consisting of polarized epithelia as well, including the kidney, exocrine pancreas and gastrointestinal tract, since similar polarized Ca2+ waves occur in the cells comprising those tissues...
  33. Pioglitazone Therapy for Endocrine and Exocrine Disease in Alcoholic Pancreatitis
    MATTHEW DIMAGNO; Fiscal Year: 2009
    ..Hence, with coexisting endocrine and exocrine pancreas disorders, successful treatment of one disorder may require treatment of both...
  34. ETHANOL AND PANCREATITIS
    Fred Gorelick; Fiscal Year: 1999
    ..that will discuss alcohol-induced injury with particular emphasis on the effect of this agent on the exocrine pancreas. Ethanol toxicity may be related to both its acute and chronic effects...
  35. Analysis of zebrafish exocrine pancreas development
    NELSON YEE; Fiscal Year: 2006
    ..However, the molecular mechanism that regulates histogenesis and cytodifferentiation of the exocrine pancreas is poorly understood...
  36. Zebrafish studies of exocrine pancreatic precursors
    Steven Leach; Fiscal Year: 2005
    The identity and location of epithelial precursor cells in exocrine pancreas remain unknown...
  37. ECOGENETICS OF PANCREATIC CANCER--FAMILY REGISTRY
    John Mulvihill; Fiscal Year: 2000
    DESCRIPTION: Pancreatic cancer, mostly adenocarcinoma of the exocrine pancreas, is the 5th leading cause of cancer deaths, totalling an estimated 26,300 new cases and 27,800 deaths in 1996...
  38. CHARACTERIZATION AND SORTING OF ZYMOGEN GRANULE PROTEINS
    ANSON LOWE; Fiscal Year: 2004
    The exocrine pancreas is responsible for the synthesis and secretion of digestive enzymes into the intestine...
  39. Susceptibility mechanism in alcoholic pancreatitis
    Herbert Gaisano; Fiscal Year: 2007
    ..chronic alcohol treatment could independently induce these downstream events to actually cause damage to the exocrine pancreas! The current consensus is that alcohol induces undefined upstream 'susceptibility' factors, which ..
  40. Developmental Genetics of Gut and Pancreas in Zebrafish
    Alan Mayer; Fiscal Year: 2005
    ..a genetic mutation in the zebrafish which exhibits abnormal intestinal cell polarity, agenesis of the exocrine pancreas, and a structural anomaly resembling imperforate anus, a common human birth defect...
  41. Pathophysiology of Arginine-induced Pancreatitis in Mice
    Ashok Saluja; Fiscal Year: 2006
    While in recent decades, considerable progress has been made in elucidating the cell biology of the exocrine pancreas, our knowledge of its pathophysiology as well as our ability to either prevent or treat pancreatitis remains very ..
  42. GENETIC SCREEN OF PANCREATIC ISLET DEVELOPMENT
    LARRY MOSS; Fiscal Year: 2002
    ..Specifically, by using molecular markers for the endocrine and exocrine pancreas, we will optimize techniques for detection of early islet development...
  43. GLP-1 regulation of endocrine pancreas growth
    DIVA DE LEON; Fiscal Year: 2001
    ..Exendin-4 also stimulates expression of PDX- 1 (a master regulator of pancreas development) in exocrine pancreas. Overexpression of PDX-1 in the exocrine pancreas increases replication rates and promotes greater response ..
  44. REGULATION OF PANCREATIC EXOCRINE FUNCTION BY MANAGANESE
    Murray Korc; Fiscal Year: 1991
    The acinar cell of the exocrine pancreas synthesizes and secretes approximately 20 digestive enzymes. Both dietary and hormonal factors have been implicated in the regulation of the synthesis of these enzymes...
  45. STIMULUS-SECRETION COUPLING IN THE EXOCRINE PANCREAS
    Michael Steer; Fiscal Year: 1991
    ..These studies will greatly extend our understanding of stimulus-secretion coupling in the exocrine pancreas as well as in other secretory systems.
  46. INOSITOL TRIPHOSPHATE-SENSITIVE CA STORE--CALCIOSOME
    Pompeo Volpe; Fiscal Year: 1990
    ..proposed research is the biochemical, functional and morphological characterization of the calciosomes of exocrine pancreas and brain...
  47. FOLATE, HOMOCYSTEINE AND METHYL GROUP METABOLISM
    Conrad Wagner; Fiscal Year: 2003
    ..first isolated as a folate binding protein, is an abundant tetrameric enzyme in liver cytosol and the exocrine pancreas. It maintains the ratio of S- adenosylmethionine (SAM) to S-adenosylhomocysteine which regulates all ..
  48. The role of Gata 4 in exocrine pancreas development
    Lori Sussel; Fiscal Year: 2007
    ..provided by applicant): The ultimate goal of this study is to elucidate the molecular regulation of exocrine pancreas specification and differentiation...
  49. Exocrine Pancreas & Intestinal Epithelial Development
    Michael Pack; Fiscal Year: 2005
    DESCRIPTION (Provided by Applicant): The exocrine pancreas and intestine play essential roles in vertebrate physiology. For both organs cell renewal also has an important homeostatic role...
  50. Transcriptional regulation of exocrine development
    Lori Sussel; Fiscal Year: 2002
    ..other developmental systems, the molecular mechanisms that direct the development and differentiation of the exocrine pancreas are likely to involve a complex network of regulatory factors...
  51. Cloning of Zebrafish exocrine pancreas mutant
    NELSON YEE; Fiscal Year: 2006
    ..One (1)unique mutant, exocrine and pigmentation (eap), has small exocrine pancreas, normal islet and reduced skin pigment...
  52. Laser Microdissection System
    Eric Olson; Fiscal Year: 2004
    ..of transcription factors that establish and maintain the developmental program specific for the exocrine pancreas (MacDonald); (8) Identification of regulatory genes that control salivary gland development (MacDonald); (9) ..
  53. Proteome of Pancreatic Zymogen Granules
    MICHAEL RINDLER; Fiscal Year: 2006
    This proposal concerns the identification of novel proteins stored in secretory granules from exocrine pancreas by taking advantage of recent improvements in protein sequencing technology and in genomic sequence identification...
  54. Cadmium & Pancreatic Cancer: A Pilot Case-Control Study
    Gary Schwartz; Fiscal Year: 2003
    ..Our Specific Aims are to: 1. Recruit 50 patients with incident cancer of the exocrine pancreas (cases) seen at Wake Forest University Baptist Medical Center (WFUBMC). 2...
  55. Mechanisms of Protein Malnutrition-Induced Exocrine Pancreas Dysfunction
    STEPHEN CROZIER; Fiscal Year: 2009
    ..of food and delivery of nutrients throughout the body is dependent upon the enzymes produced in the exocrine pancreas. Individuals lacking protein in their diet often have pancreatic dysfunction and are unable to properly ..
  56. STAGING PANCREATIC CANCER WITH DIFFERENTIATION MARKERS
    Vito Quaranta; Fiscal Year: 1990
    Major advances in the understanding of carcinoma of the exocrine pancreas (pc) could be spawned by novel means of classifying pc specimens according to (1) normal cell of origin and (2) degree of differentiation...
  57. ACINAR-DUCT CELL COUPLING IN PANCREATIC FUNCTION
    Steven Freedman; Fiscal Year: 2006
    ..excessive inflammatory response characteristic of CF and (ii) play a role in apical membrane events in the exocrine pancreas. This proposal will build upon these observations and (i) determine the mechanism by which defects in CFTR ..
  58. GASTROINTESTINAL AND EXTRAENTERIC ACTIONS OF PEPTIDE YY
    GEORGE GREELEY; Fiscal Year: 1990
    ..4. To investigate the effect of PYY neutralization on the secretory responses of the stomach and of the exocrine pancreas. It is hoped that the above research will contribute to our understanding of the role of PYY in normal gut ..
  59. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
    ..Currently, little is known of the distribution of Hh-responsive cells in the mature exocrine pancreas, the requirement for this pathway in pancreatic epithelial regeneration, and most importantly, the role of ..
  60. Pancreatic Function: G-Protein Mediated Ca2+ Signaling
    David Yule; Fiscal Year: 2007
    ..secretagogue stimulation plays a fundamental role in underlying digestive enzyme secretion from the exocrine pancreas. The increase in [Ca2+] is a tightly regulated event and exhibits characteristic temporal and spatial ..
  61. MEASURING OF PANCREATIC BETA-CELL MASS BY IMAGING
    Anna Moore; Fiscal Year: 2001
    ..binding and accumulation to beta-cells occurs following IV administration with virtually no binding to exocrine pancreas nor stromal tissues, setting an ideal stage for the proposed work...
  62. MECHANISMS OF PANCREATIC ELECTROLYTE & WATER SECRETION
    WILLIAM GALEY; Fiscal Year: 1980
    This work is aimed at determining the mechanisms by which electrolytes and water are secreted by the exocrine pancreas. Micro-pH and PCO2 electrodes as well as micropuncture and microperfusion techniques are being used to measure ionic ..