pancreatic juice

Summary

Summary: The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.

Top Publications

  1. ncbi Relationship between grade of fibrosis in pancreatic stump and postoperative pancreatic exocrine activity after pancreaticoduodenectomy: with special reference to insufficiency of pancreaticointestinal anastomosis
    Eiji Uchida
    First Department of Surgery, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 69:549-56. 2002
  2. ncbi The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate
    M J Rindler
    Department of Cell Biology, New York University Medical Center, NY 10016
    Eur J Cell Biol 53:154-63. 1990
  3. pmc Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers
    Shalini Makawita
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Proteomics 10:M111.008599. 2011
  4. pmc Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    Mei Tian
    Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China
    BMC Cancer 8:241. 2008
  5. ncbi Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer
    Jeong Youp Park
    Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    J Cancer Res Clin Oncol 137:1229-38. 2011
  6. ncbi Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 11:2285-92. 2005
  7. ncbi Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer
    Yasushi Hashimoto
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Surgery 143:113-25. 2008
  8. ncbi Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification
    K Seki
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8122, Japan
    Clin Cancer Res 7:1976-81. 2001
  9. ncbi A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice
    Koushiro Ohtsubo
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    JOP 9:37-45. 2008
  10. ncbi Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters
    D Lombardo
    Biochim Biophys Acta 611:147-55. 1980

Detail Information

Publications203 found, 100 shown here

  1. ncbi Relationship between grade of fibrosis in pancreatic stump and postoperative pancreatic exocrine activity after pancreaticoduodenectomy: with special reference to insufficiency of pancreaticointestinal anastomosis
    Eiji Uchida
    First Department of Surgery, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 69:549-56. 2002
    ..The aim of this study was to evaluate the local factors that affect the incidence of PIA leakage by evaluation of exocrine function and fibrosis in the pancreatic remnant following PD...
  2. ncbi The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate
    M J Rindler
    Department of Cell Biology, New York University Medical Center, NY 10016
    Eur J Cell Biol 53:154-63. 1990
    GP-2 is the major secretory granule membrane glycoprotein of the exocrine pancreas and appears in the pancreatic juice in a modified sedimentable form...
  3. pmc Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers
    Shalini Makawita
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Proteomics 10:M111.008599. 2011
    ..The present study details the combined mining of pancreatic cancer-related cell line conditioned media and pancreatic juice for identification of putative diagnostic leads...
  4. pmc Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    Mei Tian
    Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China
    BMC Cancer 8:241. 2008
    ..b>Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins ..
  5. ncbi Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer
    Jeong Youp Park
    Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    J Cancer Res Clin Oncol 137:1229-38. 2011
    Protein profiles of endoscopically collected pancreatic juice from normal, chronic pancreatitis patients and pancreatic cancer patients were compared to identify diagnostic biomarkers of pancreatic cancer.
  6. ncbi Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 11:2285-92. 2005
    ..we measured telomerase activity and hTERT expression in pancreatic cancer cell lines, pancreatic tissues, and pancreatic juice samples from patients with different pancreatic diseases...
  7. ncbi Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer
    Yasushi Hashimoto
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Surgery 143:113-25. 2008
    ..of immunohistochemistry (IHC) for the diagnosis of pancreatic cancer, hTERT expression and telomerase activity were assayed in pancreatic tissues, ex vivo brushing, and pancreatic juice samples with various pancreatic diseases.
  8. ncbi Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification
    K Seki
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8122, Japan
    Clin Cancer Res 7:1976-81. 2001
    ..message, a catalytic domain of human telomerase, in endoscopic retrograde pancreatography (ERP)-derived pancreatic juice. EXPERIMENTAL DESIGN: Both hTERT and CD25 expression were detected by reverse transcription-PCR (RT-PCR) in ..
  9. ncbi A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice
    Koushiro Ohtsubo
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    JOP 9:37-45. 2008
    ..There have been some cases of an ambiguous diagnosis although care was taken to differentiate between alcoholic mass-forming pancreatitis, focal type autoimmune pancreatitis and pancreatic cancer...
  10. ncbi Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters
    D Lombardo
    Biochim Biophys Acta 611:147-55. 1980
    ..The other site, unspecific towards bile salts hydroxylation would be located at the active center and would be implicated in substrate recognition...
  11. ncbi Enrichment of mutant KRAS alleles in pancreatic juice by subtractive iterative polymerase chain reaction
    C Fischer
    Department of Clinical Chemistry, Clinic for Internal Medicine, University Hospital Eppendorf, Hamburg
    Lab Invest 81:827-31. 2001
    ..To prove the feasibility of siPCR, pancreatic juice samples were analyzed for KRAS mutations...
  12. ncbi MicroRNA expression analyses in preoperative pancreatic juice samples of pancreatic ductal adenocarcinoma
    Yoshihiko Sadakari
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    JOP 11:587-92. 2010
    Cytological assessment of pancreatic juice is commonly used to diagnose pancreatic ductal adenocarcinoma; however, the sensitivity of cytological assessment has been reported to be low...
  13. ncbi Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma
    Koushiro Ohtsubo
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Gastroenterol 41:791-7. 2006
    ..We analyzed ppENK hypermethylation in pure pancreatic juice (PPJ) in patients with PCa, intraductal papillary mucinous neoplasms (IPMN), and chronic pancreatitis (CP), ..
  14. ncbi Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis
    Hiroyuki Watanabe
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Pancreas 30:349-54. 2005
    ..We evaluated mesothelin mRNA expression in pure pancreatic juice (PPJ) obtained from patients with PCa, chronic pancreatitis (CP), and intraductal papillary mucinous neoplasm ..
  15. pmc MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
    Nils Habbe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Biol Ther 8:340-6. 2009
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  16. ncbi Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology
    Christophe Rosty
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Res 62:1868-75. 2002
    ..ProteinChip technology (Ciphergen Biosystems, Fremont, CA) to screen for differentially expressed proteins in pancreatic juice. Pancreatic juice samples obtained from patients undergoing pancreatectomy for pancreatic adenocarcinoma were ..
  17. ncbi Percutaneous embolization of the distal pancreatic duct to treat intractable pancreatic juice fistula
    M Hirota
    Department of Surgery II, Kumamoto University Medical School, Kumamoto-city, Japan
    Pancreas 22:214-6. 2001
    ..In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region...
  18. ncbi Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy
    Melissa Oliveira-Cunha
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, UK
    Pancreas 39:171-4. 2010
    There is a need to develop methods of early diagnosis for pancreatic cancer. Pancreatic juice is easily collected by endoscopic retrograde cholangiopancreatography and may facilitate diagnosis using molecular markers...
  19. pmc Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia
    Ru Chen
    GI Division Department of Medicine, University of Washington, Seattle, WA 98195 USA
    Mol Cancer 9:149. 2010
    ..We applied quantitative proteomics to identify aberrantly elevated proteins in pancreatic juice samples derived from patients with PanIN3.
  20. ncbi Protein profiling in pancreatic juice for detection of intraductal papillary mucinous neoplasm of the pancreas
    Yoshihiko Shirai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Hepatogastroenterology 55:1824-9. 2008
    ..Recent advances in proteomic analysis are remarkable; therefore we explored novel biomarkers for IPMN using Surface-Enhanced Laser Desorption and Ionization (SELDI) Mass Spectrometry...
  21. ncbi In situ telomerase activity in pancreatic juice may discriminate pancreatic cancer from other pancreatic diseases
    Hiroyuki Uehara
    Departments of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Pancreas 36:236-40. 2008
    Detection of telomerase activity in pancreatic juice samples by telomeric repeat amplification protocol (TRAP) has been shown to be a useful diagnostic test for pancreatic cancer...
  22. ncbi Identification of tobacco-derived compounds in human pancreatic juice
    Bogdan Prokopczyk
    American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:677-85. 2002
    ..was conducted to determine whether cotinine and tobacco-specific nitrosamines (TSNA) are present in human pancreatic juice. Smoking status was assessed by the determination of levels of urinary cotinine and was further supported by ..
  23. ncbi Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs
    Carmelle D Rogers
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:1383-9. 2006
    ..We hypothesized that gene expression alterations indicative of pancreatic cancer can be detected by profiling the RNA of pancreatic juice.
  24. ncbi Evidence for the existence of procolipase in chicken pancreas and pancreatic juice
    I Bosc-Bierne
    Biochimie 66:413-6. 1984
    ..those of the precursor form of colipase (procolipase) previously isolated from porcine and equine pancreas or pancreatic juice. Further evidence for the existence of procolipase was obtained from kinetic studies of the hydrolysis of the ..
  25. ncbi Squeezing data from pancreatic juice
    Craig R Tomlinson
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Cancer Biol Ther 5:1390-1. 2006
  26. ncbi Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice
    A M De Caro
    Centre de Biochimie et de Biologie Moleculaire du CNRS, Marseille, France
    Eur J Biochem 168:201-7. 1987
    ..The protein studied was the lowest-Mr form prepared from human pancreatic juice (PSP S1). The N-terminal sequence up to residue 65 had already been determined...
  27. ncbi Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma
    Koji Yoshida
    Division of Functional Genomics, Jichi Medical School, Kawachi gun, Tochigi
    Cancer Sci 94:263-70. 2003
    ..effect, the pancreatic ductal epithelial cells were purified by MUC1-based affinity chromatography from pancreatic juice isolated from both healthy individuals and PDC patients...
  28. ncbi Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs
    Yansong Bian
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:1392-9. 2006
    ..We applied this assay to detect p53 and p16 mutations in pancreatic juice obtained from patients undergoing evaluation and treatment of pancreatic disease...
  29. ncbi Diagnostic utility of aberrant methylation of tissue factor pathway inhibitor 2 in pure pancreatic juice for pancreatic carcinoma
    Peihong Jiang
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Cancer Sci 97:1267-73. 2006
    ..We analyzed the aberrant methylation of TFPI-2 in the pure pancreatic juice (PPJ) aspirated endoscopically from patients with various pancreatic diseases...
  30. ncbi DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease
    Hiroyuki Matsubayashi
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Cancer Res 66:1208-17. 2006
    ..Methylation analysis was done on pancreatic juice collected endoscopically or surgically from 155 individuals with suspected pancreatic disease: 56 patients ..
  31. ncbi Progress on molecular markers of pancreatic cancer
    Tobias Grote
    Department of Cancer Biology, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Curr Opin Gastroenterol 23:508-14. 2007
    ..To describe advances in the development of biomarkers for pancreatic cancer over the past year...
  32. ncbi Matrix metalloproteinase-2 in pancreatic juice for diagnosis of pancreatic cancer
    Motohiro Yokoyama
    Department of Laboratory Medicine, Okayama University Medical School, Okayama, Japan
    Pancreas 24:344-7. 2002
    ..Matrix metalloproteinase-2 (MMP-2) has an activity to degrade type IV collagen and is associated with invasion angiogenesis of malignant tumor...
  33. pmc Identifying molecular markers for the early detection of pancreatic neoplasia
    Michael Goggins
    Department of Pathology, Medicine, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Semin Oncol 34:303-10. 2007
    ..As we continue to characterize the genetic, epigenetic, and proteomics alterations that occur in pancreatic cancers and their percursors, better diagnostic markers of pancreatic cancer are expected to follow...
  34. ncbi S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Cancer Epidemiol Biomarkers Prev 16:649-54. 2007
    ..did quantitative real-time reverse transcription-PCR to measure mRNA expression in microdissected cells and pancreatic juice samples...
  35. ncbi Gabexate mesilate (FOY) inhibition of amylase and phospholipase A(2) activity in sow pancreatic juice
    Roberto Caronna
    Dipartimento di Chirurgia Pietro Valdoni, Universita di Roma La Sapienza, Rome, Italy
    J Invest Surg 16:345-51. 2003
    ..this study in sows to investigate the enzyme inhibitory action of gabexate mesylate (GM) directly in the pancreatic juice. We studied 16 sows, each weighing about 130 kg...
  36. pmc Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis
    Ru Chen
    Division of Gastroenterology Department of Medicine, University of Washington, Seattle, WA, USA
    Pancreas 34:70-9. 2007
    ..Biomarkers present in pancreatic cancer frequently occur in the setting of pancreatitis. The efforts to develop diagnostic biomarkers for pancreatic cancer have thus been complicated by the false-positive involvement of pancreatitis...
  37. ncbi Effect of the antibacterial activity of pig pancreatic juice on human multiresistant bacteria
    Danuta Kruszewska
    Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden
    Pancreas 28:191-9. 2004
    ..The role of the exocrine pancreas in regulating gut microflora colonization is unclear. The main objective in the current study was to assess the effect of pancreatic fluid on the growth of pathogenic bacteria and fungi...
  38. ncbi Pancreatitis-associated protein levels in pancreatic juice from patients with pancreatic diseases
    Y Motoo
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, 4 86 Yoneizumi, Kanazawa 921 8044, Japan
    Pancreatology 1:43-7. 2001
    ..Although PAP was originally identified in pancreatic juice, there has been no clinical report on PAP levels in pancreatic juice...
  39. ncbi A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, UPMC Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Pancreas 29:e30-40. 2004
    ..To develop a simple, physiologically based mathematical model of pancreatic duct cell secretion using experimentally derived parameters that generates pancreatic fluid bicarbonate concentrations of >140 mM after CFTR activation...
  40. ncbi Comparative proteomic analysis of human pancreatic juice: methodological study
    Lu Zhou
    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, Peoples Republic of China
    Proteomics 7:1345-55. 2007
    ..Here, we optimized and applied a proteome analysis of human pancreatic juice to identify biomarkers for pancreatic cancer...
  41. ncbi Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 118:405-11. 2006
    b>Pancreatic juice is a promising type of diagnostic sample for pancreatic cancer, and members of the mucin (MUC) family are diagnostic candidates...
  42. ncbi Effects of gabexate mesilate (FOY) on amylase and phospholipase A2 in human serum and pancreatic juice
    Roberto Caronna
    Istituto Dipartimentalizzato di Chirurgia d Urgenza e Pronto Soccorso, Universita di Roma La Sapienza, Viale del Policlinico 155, Roma, Italy
    Dig Dis Sci 50:868-73. 2005
    ..We designed this study to investigate the enzyme inhibitory action of GM in the serum and directly in the pancreatic juice. We observed 16 cases with postoperative pancreatic drainage...
  43. ncbi Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy
    Akira Nakashima
    Division of Clinical Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Pancreas 38:527-33. 2009
    ..In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunohistochemistry for ..
  44. ncbi Comprehensive proteomic analysis of human pancreatic juice
    Mads Grønborg
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Proteome Res 3:1042-55. 2004
    ..In this study, we carried out a comprehensive characterization of the "pancreatic juice proteome" in patients with pancreatic adenocarcinoma...
  45. ncbi Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms: clinical implications of mRNA levels in pancreatic juice
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Pathol 210:42-8. 2006
    ..008). Pancreatic juice analyses (20 samples from pancreatic cancers, 31 samples from IPMNs, and 27 samples from chronic pancreatitis)..
  46. ncbi High concentration of kynurenic acid in bile and pancreatic juice
    Piotr Paluszkiewicz
    Department of Surgery and Surgical Nursing, Medical University, Chodzki 6, 20 090, Lublin, Poland
    Amino Acids 37:637-41. 2009
    ..The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography...
  47. ncbi EUS and K-ras analysis of pure pancreatic juice collected via a duodenoscope after secretin stimulation for diagnosis of pancreatic mass lesion: a prospective study
    T Okai
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Gastrointest Endosc 50:797-803. 1999
    ..This prospective study assessed the utility of a combination of endoscopic ultrasound (EUS) and genetic analysis of pure pancreatic juice in the diagnosis of pancreatic mass lesions.
  48. ncbi Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma
    A Ha
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, 4-86, Yoneizumi, Kanazawa 921-8044, Japan
    Pancreas 23:356-63. 2001
    AIMS: To ascertain whether analysis of K-ras mutations at codon 12 (KRM) in the supernatant of pure pancreatic juice (PPJ) is more useful for the diagnosis of pancreatic carcinoma (PCa) than that in sediment, the authors analyzed KRM in ..
  49. pmc Bile and pancreatic juice exclusion activates acinar stress kinases and exacerbates gallstone pancreatitis
    Isaac Samuel
    Department of Surgery, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    Surgery 143:434-40. 2008
    Bile and pancreatic juice exclusion from gut activates acinar stress kinases and exacerbates gallstone pancreatitis as evidenced by the ameliorating effects of replacement therapy in an experimental model of duct ligation-induced acute ..
  50. ncbi Pancreatic juice output and amylase level in the drainage fluid after pancreatoduodenectomy in relation to leakage
    Naoki Hashimoto
    Second Department of Surgery, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka, Sayama, Osaka 589 8511, Japan
    Hepatogastroenterology 49:553-5. 2002
    ..The objective of this study was to clarify the relationship between the consistency of the pancreas and pancreatic anastomotic leakage after pancreatectomy...
  51. ncbi Obestatin stimulates the secretion of pancreatic juice enzymes through a vagal pathway in anaesthetized rats - preliminary results
    M Kapica
    Department of Biochemistry and Animal Physiology, Faculty of Veterinary Medicine, Agricultural University in Lublin, Lublin, Poland
    J Physiol Pharmacol 58:123-30. 2007
    ..The aim of the present study was to determine the influence of exogenous obestatin on the secretion of pancreatic juice. In anesthetized male Wistar rats the external jugular vein was catheterized, and the common biliary-..
  52. ncbi Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA
    Cécilia Eydoux
    Laboratoire d Enzymologie Interfaciale et de Physiologie de la Lipolyse, UPR 9025, CNRS Institut de Biologie Structurale et Microbiologie, 31, Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochim Biophys Acta 1760:1497-504. 2006
    ..An ELISA was developed for specifically measuring the HPLRP2 levels in pure pancreatic juice. This procedure was performed using the anti-peptide HPLRP2 antibody as the captor antibody and a ..
  53. ncbi Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 120:1634-40. 2007
    ..from 19 sections, PanIN from 6 sections, and pancreatitis-affected epithelial cells from 14 sections), and pancreatic juice (16 from cancer, 28 from IPMN, and 17 from pancreatitis)...
  54. ncbi Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice
    P E Queneau
    , , , , France
    Am J Gastroenterol 96:700-4. 2001
    ..mutations were examined by two-step polymerase chain reaction combined with restriction enzyme digestion in pancreatic juice collected during endoscopic retrograde pancreatography. RESULTS: Ten patients (27...
  55. ncbi Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species
    J De Caro
    Laboratoire de Lipolyse Enzymatique, UPR 9025 de l IFRC 1 du CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochim Biophys Acta 1387:331-41. 1998
    ..It was established for the first time that this protein is secreted in variable amounts by the adult exocrine pancreas of several species...
  56. ncbi Parenteral versus early intrajejunal nutrition: effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis
    Huan long Qin
    Department of Surgery, Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    World J Gastroenterol 9:2270-3. 2003
    ..To evaluate the effect of early intrajejunal nutrition (EIN) on the natural course, entero-hormone secretion and its efficacy on dogs with acute pancreatitis...
  57. ncbi Age- and disease-related methylation of multiple genes in nonneoplastic duodenum and in duodenal juice
    Hiroyuki Matsubayashi
    Department of Pathology, Division of Biostatistics, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Clin Cancer Res 11:573-83. 2005
    ....
  58. ncbi A new model of chronic pancreatitis in rats
    Mitsuyoshi Yamamoto
    Dept of Gastroenterology and Metabolism, School of Medicine, Univ of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G700-8. 2006
    ..PDH was gradually increased, but when the pancreatic juice (PJ) flow was interrupted, PDH was decreased to restore PJ flow...
  59. ncbi Clinical significance of the accessory pancreatic duct
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677 Tokyo, Japan
    Hepatogastroenterology 50:2196-8. 2003
    ..The accessory pancreatic duct is the smaller and less constant pancreatic duct in comparison with the main pancreatic duct. We investigated the patency of the accessory pancreatic duct and its role in pancreatic pathophysiology...
  60. ncbi Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion
    Wen Chao Zhao
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, SAR, China
    World J Gastroenterol 9:2505-8. 2003
    ..To investigate the effect of tetramethylpyrazine (ligustrazine, TMP) on the secretion of exocrine pancreas (and biliary)...
  61. ncbi Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro
    Jolanta Jaworek
    Physiology, Jagiellonian University Collegium Medicum, Krakow, Poland
    J Pineal Res 36:155-64. 2004
    ..amylase secretion under basal conditions or following stimulation of enzyme secretion by diversion of bile-pancreatic juice. This was accompanied by a dose-dependent rise in melatonin plasma level...
  62. ncbi Rapid endoscopic secretin stimulation test and discrimination of chronic pancreatitis and pancreatic cancer from disease controls
    Massimo Raimondo
    Division of Gastroenterology and Hepatology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Clin Gastroenterol Hepatol 1:397-403. 2003
    ..Our aim was to develop a rapid pancreatic function test performed during upper endoscopy that could discriminate between patients with normal from impaired exocrine pancreatic secretion...
  63. ncbi Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups
    Li Yan
    Division of Surgery aned Oncology, University of Liverpool, England
    Gastroenterology 128:2124-30. 2005
    ..Screening of high-risk groups for pancreatic cancer has not been adopted because of concerns regarding specificity and sensitivity. Suitability of a combination of 3 novel molecular screening techniques was investigated...
  64. ncbi A highly sensitive and quantitative telomerase activity assay with pancreatic juice is useful for diagnosis of pancreatic carcinoma without problems due to polymerase chain reaction inhibitors: analysis of 100 samples of pancreatic juice from consecutive
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer 101:2309-17. 2004
    ....
  65. ncbi A subsegmental pancreatectomy performed for carcinoma in situ limited to the proximal half of the pancreatic head with the aid of intraoperative 4-segment cytology for pancreatic juice--a case report
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 138:947-50. 2005
  66. ncbi Three-day enteral exposure to a red kidney bean lectin preparation enhances the pancreatic response to CCK stimulation in suckling pigs
    L Evilevitch
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Biol Neonate 87:20-5. 2005
    ..A reason for the digestive problems that often occur around early weaning in piglets could be that the pancreas is not yet fully developed and the enzymes required for degradation of the solid food are not secreted in enough amounts...
  67. ncbi Mechanism of exocrine pancreatic insufficiency in streptozotocin-induced diabetes mellitus in rat: effect of cholecystokinin-octapeptide
    R Patel
    Department of Biological Sciences, University of Central Lancashire, Preston, England, UK
    Mol Cell Biochem 261:83-9. 2004
    This study investigated the effects of cholecystokinin-octapeptide (CCK-8) on pancreatic juice flow and its contents, and on cytosolic calcium (Ca2+) and magnesium (Mg2+) levels in streptozotocin (STZ)-induced diabetic rats compared to ..
  68. ncbi Liver, pancreas and biliary tract enhanced lipoperoxidation products in pure pancreatic juice: evidence for organ-specific oxidative stress in chronic pancreatitis
    S A Santini
    Institute of Biochemistry and Clinical Biochemistry, Catholic University School of Medicine, Largo A Gemelli 8, 00168 Rome, Italy
    Dig Liver Dis 35:888-92. 2003
    ..Oxygen-free radicalscan play a role in the development of chronic pancreatitis, altering the redox state with damage of cell constituents and decrease in antioxidant defences...
  69. ncbi ATP and ATPase secretion by exocrine pancreas in rat, guinea pig, and human
    Krisztina Sz Kordás
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Pancreas 29:53-60. 2004
    ..role of endogenous ATP in pancreatic function by measuring ATP concentrations and ATPase activity in pancreatic juice obtained from anesthetized rats and guinea pigs and from human patients undergoing endoscopy...
  70. ncbi [Mechanism of biliary carcinogenesis in patients with pancreaticobiliary maljunction]
    Toshiki Matsubara
    Matsubara Clinic
    Nihon Rinsho 64:354-7. 2006
  71. ncbi Initial experience with a new peroral electronic pancreatoscope with an accessory channel
    Tadashi Kodama
    Department of Gastroenterology, Kitade Hospital, Gobo, Japan
    Gastrointest Endosc 59:895-900. 2004
    ..A peroral electronic pancreatoscope was previously developed to improve visualization of the pancreatic duct, but this instrument had no accessory channel...
  72. ncbi Differential increases in syntheses of newly identified trypsinogen 2 isoforms by dietary protein in rat pancreas
    Hiroshi Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Exp Biol Med (Maywood) 229:772-80. 2004
    ..We conclude that increases in synthesis of a few newly identified trypsinogen 2-x isoforms mainly contribute to the induction of trypsin activity in the pancreas by HC in PBD rats...
  73. ncbi Mechanism of acute pancreatitis exacerbation by enteral bile-pancreatic juice exclusion
    Isaac Samuel
    Department of Surgery, University of Iowa Roy J and Lucille A Carver College of Medicine and VA Medical Center, Iowa City, IA 52242, USA
    Pancreatology 4:527-32. 2004
    Using an original model, the donor rat model, we previously showed that bile-pancreatic juice exclusion from gut exacerbates ligation-induced acute pancreatitis...
  74. ncbi Impaired pancreatic endocrine and exocrine responses in growth-retarded piglets
    E Harada
    Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori, Japan
    J Vet Med A Physiol Pathol Clin Med 50:433-41. 2003
    ..Blood and pancreatic juice were collected from these animals (6-8-weeks old)...
  75. ncbi Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors
    Maria E Sabbatini
    Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junín 956 piso 5, 1113 Buenos Aires, Argentina
    Am J Physiol Gastrointest Liver Physiol 285:G929-37. 2003
    ..ANF decreased chloride secretion and increased the pH of the pancreatic juice. Neither cholinergic nor adrenergic blockade affected ANF-stimulated pancreatic secretion...
  76. ncbi Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves
    A Leja-Szpak
    Department Med Physiol Faculty of Health Care, Jagiellonian University Collegium Medicum, Cracow, Poland
    J Physiol Pharmacol 55:33-46. 2004
    ..Melatonin (1, 5 or 25 mg/kg) or L-tryptophan (10, 50 or 250 mg/kg) were administered i.d. Samples of pancreatic juice were collected in 15 minutes aliquots. Tarazepide (2,5 mg/kg i.p...
  77. ncbi Exogenous leptin inhibits the secretion of pancreatic juice via a duodenal CCK1-vagal-dependent mechanism in anaesthetized rats
    R Matyjek
    The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05 110 Jablonna, Poland
    Regul Pept 114:15-20. 2003
    ..In this study, we investigated the influence of leptin on the secretion of pancreatic juice in biliary-pancreatic duct cannulated anaesthetised rats and in dispersed rat pancreatic acini in vitro...
  78. ncbi Food and secretagogue stimulation decrease the digestive enzyme content remaining in the rat pancreas
    Klas M Rådberg
    Department of Animal Physiology, Lund University, Sweden
    Comp Med 52:32-5. 2002
    ..5 h of pancreatic juice collection before euthanasia and pancreatic excision...
  79. ncbi Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice
    Soichi Takiguchi
    Division of Chemotherapy, National Kyushu Cancer Center, Minamiku Fukuoka, Japan
    Pancreas 24:276-83. 2002
    ..The CCK receptors can be pharmacologically subdivided into two subtypes: CCK-A and CCK-B. CCK-A receptor is enriched in the pancreas of mice...
  80. ncbi Inhibitory effects of octreotide on luminal cholecystokinin-releasing factor, plasma cholecystokinin, and pancreatic secretion in conscious rats
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Pancreas 24:269-75. 2002
    Luminal cholecystokinin-releasing factor (LCRF), purified from rat intestinal secretions, is an intraluminal regulator of cholecystokinin (CCK) secretion during bile and pancreatic juice diversion.
  81. ncbi Immunoglobulin A secretion into pancreatic juice as a novel marker of local immune defense and exocrine pancreatic function
    G Ohshio
    Department of Surgery, Shiga Medical Center for Adults, Moriyama, Japan
    Dig Dis Sci 46:2140-6. 2001
    ..However, very little is known about IgA in pancreatic juice. Pure pancreatic juice was collected from 40 patients undergoing pancreatoduodenectomy...
  82. ncbi Pancreatic intraductal sampling during ERCP in patients with chronic pancreatitis and pancreatic cancer: cytologic studies and k-ras-2 codon 12 molecular analysis in 47 cases
    V Pugliese
    Center for Gastrointestinal Endoscopy, The Department of Oncology, University of Genoa, Italy
    Gastrointest Endosc 54:595-9. 2001
    ..METHODS: Pancreatic brush cytology, salvage cytology, and collection of pancreatic juice were attempted prospectively during ERCP in 34 patients with pancreatic cancer and 11 with chronic ..
  83. ncbi Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis
    S D Freedman
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 121:950-7. 2001
    ..The aim of this study was to determine in cftr(-/-) mice (1) if the pH of the pancreatic juice is acidic compared with wild-type (WT) controls, (2) if there is a selective block in endocytosis, and (3) if ..
  84. pmc 5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells
    A Suzuki
    Internal Medicine II, Nagoya University School of Medicine, Nagoya, Japan
    J Clin Invest 108:749-56. 2001
    ..5-HT released from pancreatic ductal EC cells on elevation of the intraductal pressure may regulate fluid secretion of neighboring duct cells in a paracrine fashion...
  85. ncbi Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
    Chanjuan Shi
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 7:353-360. 2008
    ..For all pancreatic adenocarcinoma patients, the dominant KRAS2 mutation detected in the pancreatic juice corresponded to that found in the primary cancer...
  86. ncbi Clinicopathological study on the intraductal spread of small pancreatic cancer
    Osamu Takasawa
    Department of Gastroenterology, Sendai City Medical Center, 5 22 1 Tsurugaya, Miyagino ku, Sendai 983 0824, Japan
    J Gastroenterol 42:957-61. 2007
    ..The aim of this study was to evaluate histopathologically the frequency, direction, and length of intraductal spread (IS) along the main pancreatic duct from the main tumor of small pancreatic cancer...
  87. ncbi Unique activities of cholecystokinin-58; physiological and pathological relevance
    Gary M Green
    Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Curr Opin Endocrinol Diabetes Obes 15:48-53. 2008
    ..New information suggests that CCK58, the largest form of cholecystokinin detected in blood and tissue, has unique functions compared with other forms, and may be the predominant, perhaps only, circulating form in mammals...
  88. pmc Enteral exclusion increases MAP kinase activation and cytokine production in a model of gallstone pancreatitis
    Isaac Samuel
    Department of Surgery, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
    Pancreatology 8:6-14. 2008
    ..We have previously demonstrated that enteral exclusion augments pancreatic p38 mitogen-activated protein (MAP) kinase activation and tumor necrosis factor-alpha (TNF-alpha) production after bile-pancreatic duct ligation in rats...
  89. doi Pancreatic duct lavage cytology for the diagnosis of branch duct-type intraductal papillary mucinous neoplasm of the pancreas
    Jin Kan Sai
    Pancreas 36:216-7. 2008
  90. ncbi Pancreas divisum in pancreaticobiliary maljunction
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo 113 8677, Japan
    Hepatogastroenterology 55:249-53. 2008
    ..They are possibly the result of bile and pancreatic duct misarrangement. We investigated the configuration of the pancreatic duct in patients with PBM and its clinical implications...
  91. ncbi Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report
    T Azuma
    Second Department of Internal Medicine, Fukui Medical School, Japan
    Int J Cancer 67:492-7. 1996
    ..the pancreas, to establish an assay system of CTSE and to evaluate the diagnostic usefulness of CTSE in the pancreatic juice. Eleven patients with pancreatic ductal adenocarcinoma, 10 with mucin-producing adenoma, 3 with intraductal ..
  92. ncbi Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico-biliary diverted rats
    Tohru Hira
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita ku, Sapporo 060 8589, Japan
    Exp Physiol 92:687-94. 2007
    ..sucrose fatty acid esters on protein-induced pancreatic secretion in conscious PBD rats whose bile-pancreatic juice was diverted from the proximal small intestine through a catheter...
  93. ncbi Immunoreactive anionic and cationic trypsin in human serum
    M Kimland
    Yale University School of Medicine, New Haven CT
    Clin Chim Acta 184:31-46. 1989
    A simple method for the purification of anionic and cationic trypsinogen and trypsin from human pancreatic juice applying affinity chromatography on aprotinin coupled Sepharose is described together with the N-terminal amino acid ..
  94. ncbi S100P is an early developmental marker of pancreatic carcinogenesis
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5411-6. 2006
    ..Our goal was to clarify the involvement and clinical significance of S100P in pancreatic carcinogenesis...
  95. ncbi S100A11, a putative tumor suppressor gene, is overexpressed in pancreatic carcinogenesis
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5417-22. 2006
    ..Recent microarray analyses revealed that expression of S100A11 is up-regulated in pancreatic cancer. The aim of the present study was to evaluate the association of S100A11 with pancreatic carcinogenesis...
  96. ncbi Non-invasive quantification of pancreatic exocrine function using secretin-stimulated MRCP
    S Punwani
    Medical Imaging, Middlesex Hospital and Royal Free and University College London Medical School, Mortimer Street, London W1T 3AA, UK
    Eur Radiol 13:273-6. 2003
    ..Signal intensity was measured in samples of water, pancreatic, duodenal juice, and secretin-stimulated pancreatic juice. A water phantom was made and MR calculated volumes compared with known water volumes within the phantom...
  97. ncbi Early detection of pancreatic carcinoma
    Christophe Rosty
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Hematol Oncol Clin North Am 16:37-52. 2002
    ....
  98. ncbi Usefulness of dynamic magnetic resonance pancreatography with secretin [correction of secretion] injection for evaluating pancreatic exocrine function after pancreatogastric reconstructive surgery
    Seiji Ohhigashi
    Department of Surgery, St Luke s International Hospital, 9 1 Akashi cho, Chuo Ku, Tokyo 104 8560, Japan
    J Hepatobiliary Pancreat Surg 9:620-6. 2002
    ..The usefulness of dynamic magnetic resonance pancreatography (MRP) with secretin injection as a new method of assessing pancreatic exocrine function was evaluated in patients undergoing pancreatogastrostomy...
  99. ncbi Supramaximal CCK-58 does not induce pancreatitis in the rat: role of pancreatic water secretion
    Mitsuyoshi Yamamoto
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Physiol Gastrointest Liver Physiol 292:G964-74. 2007
    ..We conclude that CCK-58 may be a valuable tool for investigating events that trigger pancreatitis...
  100. ncbi Use of ultrasonically activated shears improves the safety of pancreaticojejunostomy after pancreaticoduodenectomy
    Tsuneo Tanaka
    Department of Surgery, Hiroshima Prefectural Hospital, 1 5 54 Ujinakanda, Minamiku, Japan
    Arch Surg 137:1258-61. 2002
    ..To study whether the use of ultrasonically activated shears (UAS) would improve the safety of pancreatojejunal anastomosis after pancreaticoduodenectomy...
  101. ncbi Direct measurement of pancreatic enzymes: a comparison of secretagogues
    Marian D Pfefferkorn
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202, USA
    Dig Dis Sci 47:2211-6. 2002
    ..262). Patients in all three groups had at least one normal enzyme. Cholecystokinin is useful as a single agent for direct pancreatic enzyme measurements in the absence of commercially available secretin...

Research Grants37

  1. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    Gallstone pancreatitis is common and is potentially fatal. Enteral exclusion of bile-pancreatic juice by the stone causes feedback hyperstimulation of the exocrine pancreas that induces pancreatic overproduction of acute inflammatory ..
  2. Role of Intra-Pancreatic Trypsinogen Activation in Alcoholic Pancreatitis
    Rajinder K Dawra; Fiscal Year: 2013
    ..Alcohol exposure is known to enhance activation of trypsinogen in acinar cells. Pancreatic juice of human alcoholics was found to have increased levels of trypsinogens...
  3. Using Markers to Improve Pancreatic Cancer Screening
    Michael G Goggins; Fiscal Year: 2013
    ..found ~99% of low-grade PanINs harbor mutations, mutations that can be detected in pancreatic duct lavages ("pancreatic juice")...
  4. Validation Study of Select Biomarkers for the Diagnostic of Pancreatic Cancer
    MICHELLE ANN ANDERSON; Fiscal Year: 2012
    ..Serum, plasma, pancreatic juice and bile will be collected and stored to form a biorepository in anticipation of future validation of serum ..
  5. Non-invasive sampling of DNA markers for pancreatic cancer screening
    Yu Tsueng Liu; Fiscal Year: 2013
    ..mutation, optimize capture and protection efficiency by the particles in vitro in the presence of bile and pancreatic juice components;(2a) By feeding cancer DNA and the particles to normal mice, test the recovery of KRAS mutations ..
  6. Biomarkers to assess progression of alcohol induced chronic pancreatitis.
    Bimaljit Singh Sandhu; Fiscal Year: 2011
    ..This hypothesis will be tested by two inter-related specific aims;(1) To develop a model using pancreatic juice pro-inflammatory cytokine levels as biomarkers to predict the development of organ failure and progression of ..
  7. Molecular Mechanisms of HCO3- Secretion by the Pancreatic Duct
    Philip J Thomas; Fiscal Year: 2010
    ..CFTR determines the final HCO3- concentration in the pancreatic juice by controlling the membrane potential of the duct...
  8. FEEDBACK REGULATION OF PANCREATIC SECRETION
    Gary Green; Fiscal Year: 2000
    ..secretion and CCK release stimulated by dietary protein, trypsin inhibitors, and diversion of bile- pancreatic juice will be investigated using immunoneutralization with anti-sera raised to the biologically active portion of ..
  9. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
    ..peptides (S-RP and CCK-RP) in the upper small intestine and by a pancreatic S-RP found in canine pancreatic juice; 2) The releases and actions of S and CCK are neurally mediated; 3) Secretin- containing endocrine cells in ..
  10. Pancreatic Juice Biomarker for Pancreatic Cancer
    Ru Chen; Fiscal Year: 2012
    ..Such lesions can be difficult to manage because of the uncertainty regarding neoplastic progression. Pancreatic juice is a proximal body fluid and represents an opportune specimen for identifying biomarkers of pancreatic cancer...
  11. FEEDBACK REGULATIION OF PANCREATIC ENZYME SECRETION
    Chung Owyang; Fiscal Year: 2000
    ..Component aims are focused to demonstrate that DBI is released into the lumen during diversion of bile-pancreatic juice and nutrient stimulation, and that its secretion parallels that of CCK...
  12. THE ROLE OF TOBACCO-SPECIFIC NITROSAMINES IN PANCREATIC CANCER
    Bogdan Prokopczyk; Fiscal Year: 2007
    ..the only known tobacco-derived products that induce cancer of the pancreas in rats, are present in human pancreatic juice. The fat content and the type of fat [omega-3 vs...
  13. A Sequencing Microarray for Mitochondrial Mutations
    Anirban Maitra; Fiscal Year: 2004
    ..eventual goal of this proposal is to enable early diagnosis of pancreas cancer using endoscopically-obtained pancreatic juice samples...
  14. Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk r*
    Paul Brennan; Fiscal Year: 2007
    ..rate for both; Extensive collection of biological samples including blood samples, viable lymphocytes, pancreatic juice and tumor tissue...
  15. Development of Immunodiagnostics for Pancreatic Cancer
    Hossein Ghanbari; Fiscal Year: 2002
    ..and specific immunoassays for the detection of HAAH in bodily fluids, and to correlate the levels of HAAH in the serum and/or pancreatic juice of individuals diagnosed with pancreatic carcinoma to disease diagnosis and patient outcome.
  16. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
    ..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page [] ..
  17. Role of trypsinogen sulfation in alcoholic pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  19. Markers of Early Pancreatic Cancer
    Michael G Goggins; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The overall goal of this project is to develop new serum and pancreatic juice markers of pancreatic cancer that can be used to diagnose patients with symptoms of their disease and to identify patients ..
  20. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  21. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  23. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  24. MOLECULAR STUDIES ON MUC1 PROMOTER
    Michael Hollingsworth; Fiscal Year: 2002
    ..In addition, activated GR can stimulate the basal activity of the MUC1 promoter independently of STAT3. STAT3 has been shown to be upregulated in breast cancer cells relative to normal breast epithelial cells. ..
  25. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  26. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  27. CLASSIFYING PANCREATIC CANCERS BY METHYLATOR PHENOTYPES
    Michael Goggins; Fiscal Year: 2006
    ..Aim #4: Determine if functional DNA methylation differences exist between CIMP+ compared to CIMP- pancreatic carcinomas. ..
  28. SPORE IN GASTOINTESTINAL CANCER
    Michael Hollingsworth; Fiscal Year: 2004
    ....
  29. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2005
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  30. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
    ..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
  31. THE PanINs OF PANCREATITIS,PANCREAS CANCER AND CONTROLS
    Michael Goggins; Fiscal Year: 2002
    ..abstract_text> ..
  32. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..
  33. FOLATE PATHWAY POLYMORPHISMS AND PANCREATIC CANCER RISK
    Michael Goggins; Fiscal Year: 2002
    ..abstract_text> ..
  34. STUDY OF REG RECEPTOR-LIGAND BIOLOGY IN GI MUCOSA
    Brian Dieckgraefe; Fiscal Year: 2008
    ..These studies will also provide new insight into the role of Reg IV antagonists and lay the groundwork for development of therapeutic reagents active in gastrointestinal adenocarcinomas. ..
  35. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2008
    ..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
  36. CCK-58 and the Two Component Paradigm for Exocrine Pancreatic Secretion
    Gary Green; Fiscal Year: 2008
    ..Our study will test a new hypothesis on how the secretions are regulated that may suggest new treatments for these diseases [unreadable] [unreadable] [unreadable] [unreadable]..