lymph

Summary

Top Publications

  1. pmc Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema
    A W B Stanton
    Department of Medicine, St George s Hospital Medical School, London
    Lymphat Res Biol 1:121-32. 2003
  2. doi Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells
    V Cerovic
    Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Mucosal Immunol 6:104-13. 2013
  3. doi The conduit system of the lymph node
    Ramon Roozendaal
    Department of Molecular Cell Biology and Immunology, Vrije University VU Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    Int Immunol 20:1483-7. 2008
  4. doi Changes in the mesenteric lymph proteome induced by hemorrhagic shock
    Anubhav Mittal
    Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Shock 34:140-9. 2010
  5. pmc A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 150:1235-48. 2012
  6. ncbi GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats
    Xiaofa Qin
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Am J Physiol Gastrointest Liver Physiol 288:G943-9. 2005
  7. pmc Bluetongue virus targets conventional dendritic cells in skin lymph
    Behzad Hemati
    Virologie et Immunologie Moléculaires, UR892 INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    J Virol 83:8789-99. 2009
  8. doi Evaluation of sentinel node biopsy by combined fluorescent and dye method and lymph flow for breast cancer
    Takashi Hojo
    National Cancer Center Hospital, Department of Surgery and Division of Breast Cancer, 5 1 1 Tsukiji Chuo ku, Tokyo, Japan
    Breast 19:210-3. 2010
  9. ncbi Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review
    Edwin A Deitch
    Department of Surgery, UMDNJ New Jersey Medical School, MSB G506, Newark, NJ 07103, USA
    Front Biosci 11:520-8. 2006
  10. ncbi Homing and cellular traffic in lymph nodes
    Ulrich H von Andrian
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusettes 02115, USA
    Nat Rev Immunol 3:867-78. 2003

Research Grants

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
  3. Yasmin Wadia; Fiscal Year: 2014
  4. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
  5. Norma S Kenyon; Fiscal Year: 2015
  6. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
  7. PAUL CAMILLE TUMEH; Fiscal Year: 2015
  8. Rinn Song; Fiscal Year: 2016
  9. DANIEL J CARR; Fiscal Year: 2015
  10. JAMES M COGHILL; Fiscal Year: 2015

Detail Information

Publications289 found, 100 shown here

  1. pmc Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema
    A W B Stanton
    Department of Medicine, St George s Hospital Medical School, London
    Lymphat Res Biol 1:121-32. 2003
    ..to axillary surgery and radiotherapy (breast cancer-related lymphedema), the swelling is largely epifascial and lymph flow per unit epifascial volume is impaired...
  2. doi Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells
    V Cerovic
    Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Mucosal Immunol 6:104-13. 2013
    Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103...
  3. doi The conduit system of the lymph node
    Ramon Roozendaal
    Department of Molecular Cell Biology and Immunology, Vrije University VU Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    Int Immunol 20:1483-7. 2008
    The lymphoid compartment of lymph nodes is impermeable to many molecules that are delivered via afferent lymphatic vessels. In the lymphoid compartment, fibroblast reticular cells form an interconnected network-the conduit system...
  4. doi Changes in the mesenteric lymph proteome induced by hemorrhagic shock
    Anubhav Mittal
    Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Shock 34:140-9. 2010
    ..active factors produced by the intestine and transported by the aqueous and protein fraction of mesenteric lymph are now thought to contribute significantly to the development of distant organ failure in hemorrhagic shock...
  5. pmc A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 150:1235-48. 2012
    The lymphatic network that transports interstitial fluid and antigens to lymph nodes constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic spread unless dissemination is blocked in the lymph node ..
  6. ncbi GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats
    Xiaofa Qin
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Am J Physiol Gastrointest Liver Physiol 288:G943-9. 2005
    ..the effect of recombinant GLP-1-(7-36) amide (rGLP-1) on lipid absorption in the small intestine in intestinal lymph duct-cannulated rats...
  7. pmc Bluetongue virus targets conventional dendritic cells in skin lymph
    Behzad Hemati
    Virologie et Immunologie Moléculaires, UR892 INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    J Virol 83:8789-99. 2009
    ..The virus initially replicates in the draining lymph node and then disseminates to secondary organs where it induces edema, hemorrhages, and necrosis...
  8. doi Evaluation of sentinel node biopsy by combined fluorescent and dye method and lymph flow for breast cancer
    Takashi Hojo
    National Cancer Center Hospital, Department of Surgery and Division of Breast Cancer, 5 1 1 Tsukiji Chuo ku, Tokyo, Japan
    Breast 19:210-3. 2010
    Conservative breast resection with subsequent sentinel lymph node biopsy (SNB) is an increasingly popular initial approach for the treatment of breast cancer due to decreased invasiveness...
  9. ncbi Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review
    Edwin A Deitch
    Department of Surgery, UMDNJ New Jersey Medical School, MSB G506, Newark, NJ 07103, USA
    Front Biosci 11:520-8. 2006
    ..based on recent experimental evidence, it appears that unique gut-derived factors carried in the intestinal lymph, but not the portal vein, lead to acute injury- and shock-induced SIRS and MODS...
  10. ncbi Homing and cellular traffic in lymph nodes
    Ulrich H von Andrian
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusettes 02115, USA
    Nat Rev Immunol 3:867-78. 2003
  11. ncbi Mesenteric lymph: the bridge to future management of critical illness
    Medhat Y Z Fanous
    Hepatobiliary, Pancreatic and Upper Gastrointestinal Unit, Department of Surgery, Auckland, New Zealand
    JOP 8:374-99. 2007
    ..Toxic factors in mesenteric lymph may induce an inflammatory systemic response while bypassing the portal circulation and liver...
  12. ncbi Profiling of normal human leg lymph proteins using the 2-D electrophoresis and SELDI-TOF mass spectrophotometry approach
    B Interewicz
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Lymphology 37:65-72. 2004
    ..The protein composition of TF remains largely unknown. The TF which has entered lymphatics is called lymph (L)...
  13. ncbi Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 450:110-4. 2007
    b>Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers...
  14. doi Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer
    Helge Wiig
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Physiol Rev 92:1005-60. 2012
    ..Accumulated recent data show that IF and its convection through the interstitium and delivery to the lymph nodes have many and diverse biological effects, including in ECM reorganization, cell migration, and capillary ..
  15. pmc Interobserver reproducibility of histologic parameters of melanoma deposits in sentinel lymph nodes: implications for management of patients with melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, Australia
    Cancer 115:5026-37. 2009
    Histologic parameters of melanoma deposits in sentinel lymph nodes (SLNs) have been shown to be predictive of clinical outcome and the presence or absence of tumor in non-SLNs, but assessment of these parameters is prone to ..
  16. ncbi B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels
    K Nakaya
    First Department of Physiology, Shinshu University School of Medicine, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan
    Am J Physiol Cell Physiol 281:C1812-8. 2001
    ..cell line (LLC) can regulate lymphatic pump activity with bioassay preparations isolated from murine iliac lymph vessels...
  17. doi Exogenous normal lymph alleviates lipopolysaccharide-induced acute kidney injury in rats
    Zi gang Zhao
    Institute of Microcirculation, Hebei North University, Zhangjiakou, Hebei, PR China
    Ren Fail 35:806-11. 2013
    ..circulation plays an important regulatory role in the pathogenesis of hemorrhage shock, and that exogenous normal lymph (ENL) has a beneficial effect on multiple organ injuries...
  18. doi Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography
    Ning Fei Liu
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Vasc Surg 49:980-7. 2009
    ..This study evaluated the anatomic and functional images of contrast MR lymphangiography in the diagnosis of limb lymphatic circulation disorders...
  19. pmc Infection of dendritic cells by the Maedi-Visna lentivirus
    S Ryan
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 OES, United Kingdom
    J Virol 74:10096-103. 2000
    ..The results of the in vivo infection experiments are supported by infections of purified afferent lymph dendritic cells in vitro, in which late reverse transcriptase products are demonstrated by PCR...
  20. ncbi Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure
    Johannes H M Levels
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 31:1647-53. 2003
    ..Lipoproteins (in particular, high-density lipoproteins) sequester LPS, thereby acting as a humoral detoxification mechanism...
  21. pmc Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct
    Anatoliy A Gashev
    Department of Medical Physiology, Cardiovascular Research Institute, College of Medicine, Texas A and M University System Health Science Center, 336 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Physiol 540:1023-37. 2002
    There are only a few reports of the influence of imposed flow on an active lymph pump under conditions of controlled intraluminal pressure. Thus, the mechanisms are not clearly defined...
  22. ncbi Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway
    Maheswari Senthil
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Ann Surg 246:822-30. 2007
    To test the hypothesis that gut-derived factors carried in trauma-hemorrhagic shock (T/HS) lymph is sufficient to induce lung injury...
  23. pmc Contractile physiology of lymphatics
    David C Zawieja
    Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M Health Science Center College of Medicine, Temple, Texas 77843 1114, USA
    Lymphat Res Biol 7:87-96. 2009
    ..Thus, the principal task of the lymphatic vascular system is transport. The body must impart energy to the lymph via pumping mechanisms to propel it along the lymphatic network and use pumps and valves to generate lymph flow ..
  24. doi Kinetics of the local immune response in the gastric lymph of lambs after primary and challenge infection with Teladorsagia circumcincta
    A M Halliday
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, UK
    Parasite Immunol 32:81-90. 2010
    ..from the previously infected sheep, and secondary cellular and humoral responses were observed in the gastric lymph. Increases in CD4+ and CD25+ T lymphoblast traffic on day 3, followed by CD21+ and IgA+ lymphoblasts on day 5, and ..
  25. doi Lymph circulation in the liver
    Osamu Ohtani
    Department of Anatomy, Faculty of Medicine and Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Anat Rec (Hoboken) 291:643-52. 2008
    The liver produces a large amount of lymph, which is estimated to be 25 to 50 % of lymph flowing through the thoracic duct...
  26. pmc D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion
    Kit Ming Lee
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    Blood 118:6220-9. 2011
    ..important for efficient flow of antigen-bearing fluid and antigen-presenting cells (APCs) from peripheral sites to lymph nodes (LNs)...
  27. pmc The gastrointestinal nematode Trichostrongylus colubriformis down-regulates immune gene expression in migratory cells in afferent lymph
    Jacqueline S Knight
    AgResearch Ltd, Hopkirk Research Institute, Grasslands Research Centre, Palmerston North 4442, New Zealand
    BMC Immunol 11:51. 2010
    ....
  28. ncbi MRI and quantification of draining lymph node function in inflammatory arthritis
    Steven T Proulx
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1117:106-23. 2007
    ..Using this approach to study synovitis and draining lymph node (LN) function we first demonstrated that the LNs of TNF-Tg mice at 5 months are significantly larger and have ..
  29. doi Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats
    Megumi Matsumoto
    Creative Research Initiative Sousei CRIS, Hokkaido University, Kita 21, Nishi 10, Kita ku, Sapporo, Hokkaido, 001 0021, Japan
    Eur J Nutr 49:243-9. 2010
    ..Fucoxanthin isolated from edible seaweeds and its metabolite fucoxanthinol have been recently found to have anti-obesity effects, but the mechanism is not fully understood...
  30. ncbi Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression
    Osamu Ohtani
    Department of Anatomy, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Arch Histol Cytol 66:261-72. 2003
    The aim of the present study was to examine the organization of lymph fluid and cellular pathways and distribution of the membrane water channel Aquaporin-1 (AQP-1) in rat lymph nodes...
  31. ncbi Collection of lymph-borne dendritic cells in the rat
    Simon W F Milling
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Protoc 1:2263-70. 2006
    ..collect antigens in peripheral tissues, and transport and process them for presentation to lymphocytes in draining lymph nodes, but they also regulate the immune response by modulating T-cell differentiation...
  32. pmc Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nematodes during infection with Trichostrongylus colubriformis
    Anton Pernthaner
    AgResearch Limited, Wallaceville Animal Research Center, P O Box 40063, Ward St, Upper Hutt, New Zealand
    Infect Immun 73:2175-83. 2005
    Cytokine gene expression in cells migrating in afferent and efferent intestinal lymph was monitored for extended time periods in individual sheep experimentally infected with the nematode Trichostrongylus colubriformis...
  33. ncbi [Lymph kinetics with technetium-99m labeled radiopharmaceuticals. Animal studies]
    M Weiss
    Klinik und Poliklinik fur Nuklearmedizin, Ludwig Maximilians Universitat Munchen, Ziemssenstrasse 1, 80335 München, Germany
    Nuklearmedizin 44:156-65. 2005
    ..Aim of this study was to characterize suitable technetium-99m labeled tracers for lymphoscintigraphy by comparative animal tests...
  34. ncbi Composition and ultrastructure of size subclasses of normal human peripheral lymph lipoproteins: quantification of cholesterol uptake by HDL in tissue fluids
    M N Nanjee
    Department of Cardiovascular Biochemistry, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Lipid Res 42:639-48. 2001
    Peripheral lymph lipoproteins have been characterized in animals, but there is little information about their composition, and none about their ultrastructure, in normal humans...
  35. pmc Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Neoplasia 10:706-13, 1 p following 713. 2008
    The growth of metastatic tumors in mice can result in markedly increased lymph flow through tumor-draining lymph nodes (LNs), which is associated with LN lymphangiogenesis...
  36. doi γδ T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent
    Manouk Vrieling
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands
    J Immunol 188:578-84. 2012
    In most species, γδ T cells preferentially reside in epithelial tissues like the skin. Lymph duct cannulation experiments in cattle revealed that bovine dermal γδ T cells are able to migrate from the skin to the draining lymph nodes ..
  37. doi Mesenteric lymph return is an important contributor to vascular hyporeactivity and calcium desensitization after hemorrhagic shock
    Zi gang Zhao
    Institute of Microcirculation, Hebei North University, Hebei, People s Republic of China
    Shock 38:186-95. 2012
    ..In this study, our aims were to determine the effects of mesenteric lymph on vascular reactivity during HS and the mechanisms involved...
  38. pmc Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid
    Xiaofa Qin
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Am J Physiol Gastrointest Liver Physiol 303:G969-78. 2012
    Recent studies have shown that mesenteric lymph plays a very important role in the development of multiple-organ dysfunction syndrome under critical conditions...
  39. pmc Loss of the intestinal mucus layer in the normal rat causes gut injury but not toxic mesenteric lymph nor lung injury
    Susan M Sharpe
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 34:475-81. 2010
    ..hypothesis is that the injury produced in the gut will result in the production of biologically active mesenteric lymph and consequently distant organ (i.e., lung) injury...
  40. pmc Lymphatic pump treatment mobilizes leukocytes from the gut associated lymphoid tissue into lymph
    Lisa M Hodge
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Forth Worth, Texas 76107, USA
    Lymphat Res Biol 8:103-10. 2010
    ..This study is the first to document LPT-induced mobilization of leukocytes from the GALT into the lymphatic circulation...
  41. ncbi Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized sheep
    Tomonobu Koizumi
    First Department of Medicine, Shinshu University School of Medicine, Asahi Matsumoto, Japan
    Anesthesiology 101:59-65. 2004
    ..The current study was designed to examine effects of a newly synthesized and selective inducible nitric oxide synthase inhibitor, ONO1714, on endotoxin-induced lung injury in unanesthetized sheep...
  42. doi Lymphatics and lymph in acute lung injury
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 14:31-6. 2008
    b>Lymph flow will be discussed as part of the drainage and fluid balance of lung tissue and abdomen as well as a qualitative analysis of inflammatory processes.
  43. pmc Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes
    Joseph C Mudd
    Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University UniversityHospitals Case Medical Center, Cleveland, OH 44106, USA
    Blood 121:2914-22. 2013
    ..We hypothesized that lymphocytes could be sequestered in the HIV-1+ lymph node (LN) through impairments in sphingosine-1-phosphate (S1P) responsiveness...
  44. ncbi The relationship of lymphocytes in blood and in lymph to sleep/wake states in sheep
    J B Dickstein
    Centre for Sleep and Chronobiology, Toronto Western Hospital, University of Toronto, Ontario, Canada
    Sleep 23:185-90. 2000
    ..Blood and lymph sample were obtained from 5 sheep during periods of slow-wave sleep and wake...
  45. ncbi Shock mesenteric lymph-induced rat polymorphonuclear neutrophil activation and endothelial cell injury is mediated by aqueous factors
    Saraswati D Dayal
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 52:1048-55; discussion 1055. 2002
    After trauma and hemorrhagic shock (T/HS), mesenteric lymph (ML) activates polymorphonuclear neutrophils (PMNs), injures endothelial cells (ECs), and predisposes to lung injury. The involved mediators, however, are unknown...
  46. ncbi Isolation and purification of afferent lymph dendritic cells that drain the skin of cattle
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Nat Protoc 1:982-7. 2006
    ..Cannulation of afferent lymphatic vessels allows the isolation of large numbers of lymph DCs. First, lymph nodes that are draining the skin are surgically removed (takes approximately 1 h)...
  47. ncbi Factors in intestinal lymph after shock increase neutrophil adhesion molecule expression and pulmonary leukosequestration
    Joseph M Caruso
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    J Trauma 55:727-33. 2003
    ....
  48. ncbi Cytokines in mammary lymph and milk during endotoxin-induced bovine mastitis
    K Persson Waller
    Department of Ruminant and Porcine Diseases, National Veterinary Institute, SE 751 89, Uppsala, Sweden
    Res Vet Sci 74:31-6. 2003
    Cytokine kinetics were examined in milk and in afferent and efferent lymph of the supramammary lymph node after intramammary infusion of endotoxin from Escherichia coli. Cows were sampled 0, 2 and 4h after infusion (p.i.)...
  49. doi The addition of SPECT/CT lymphoscintigraphy to breast cancer radiation planning spares lymph nodes critical for arm drainage
    Andrea L Cheville
    Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 85:971-7. 2013
    ..cohort study was designed to determine whether the amount of radiation delivered to the nonpathological lymph nodes (LNs) that drain the arm can be significantly reduced by integrating single-photon emission computed ..
  50. ncbi Mesenteric lymph collected during peritonitis or sepsis potently inhibits gastric motility in rats
    Jorg Glatzle
    Department of General and Transplantation Surgery, University Hospital of Tubingen, Tubingen, Germany
    J Gastrointest Surg 8:645-52. 2004
    ..motility is strongly inhibited during peritonitis or sepsis and proinflammatory cytokines released into mesenteric lymph during an acute gastrointestinal insult mediate systemic responses...
  51. ncbi Plasmacytoid dendritic cells migrate in afferent skin lymph
    Florentina Pascale
    Virologie et Immunologie Moléculaires, UR892 Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy en Josas, France
    J Immunol 180:5963-72. 2008
    Conventional dendritic cells enter lymph nodes by migrating from peripheral tissues via the lymphatic route, whereas plasmacytoid dendritic cells (pDC), also called IFN-producing cells (IPC), are described to gain nodes from blood via ..
  52. doi Assessment of IgE response and cytokine gene expression in pulmonary efferent lymph collected after ovalbumin inhalation during experimental infection of calves with bovine respiratory syncytial virus
    Laurel J Gershwin
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 72:134-45. 2011
    To assess IgE response and cytokine gene expressions in pulmonary lymph collected from bovine respiratory syncytial virus (BRSV)-infected calves after ovalbumin inhalation.
  53. pmc Nonlinear lymphangion pressure-volume relationship minimizes edema
    Arun M Venugopal
    Michael E DeBakey Institute, Texas A and M University, College Station, Texas 77843 4466, USA
    Am J Physiol Heart Circ Physiol 299:H876-82. 2010
    ..outlet pressures), lymphangions must respond to potentially large increases in transmural pressure by maintaining lymph flow...
  54. ncbi Lack of functioning lymphatics and accumulation of tissue fluid/lymph in interstitial "lakes" in colon cancer tissue
    M Stanczyk
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw
    Lymphology 43:158-67. 2010
    ..The most favorable site of entry of tumor cells to lymphatics seems to be the interface of the tumor and surrounding tissue with open lymphatics...
  55. doi Disturbance of lymph circulation develops renal fibrosis in rats with or without contralateral nephrectomy
    Taoyan Zhang
    Department of Nephrology, The Second Affiliated Hospital, Medical College of Shandong University, Jinan, China
    Nephrology (Carlton) 13:128-38. 2008
    ..Here we show the time course of renal lesions caused by long-term ligation of renal hilar lymphatic vessels in rats with or without contralateral nephrectomy...
  56. pmc DEC-205 expression on migrating dendritic cells in afferent lymph
    Daniel R Gliddon
    Institute for Animal Health, Compton, Newbury, Berks RG20 7NN, UK
    Immunology 111:262-72. 2004
    ..a 210 000-molecular weight molecule expressed at a high level on the surface of dendritic cells (DCs) in afferent lymph of cattle and evident on cells with the morphology of DCs in lymphoid tissues...
  57. doi Intraoperative application of fibrin sealant does not reduce the duration of closed suction drainage following radical axillary lymph node dissection in melanoma patients: a prospective randomized trial in 58 patients
    Heiko Neuss
    Department of General, Visceral, Thoracic and Vascular Surgery, Medical Faculty of Humboldt University, Charite Universitaetsmedizin Berlin, Charite, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    World J Surg 32:1450-5. 2008
    Patients suffering from malignant melanoma often require radical lymph node dissection of the axillary nodal basin...
  58. ncbi Manual lymph drainage efficiently reduces postoperative facial swelling and discomfort after removal of impacted third molars
    G Szolnoky
    Department of Dermatology and Allergology Phlebo Lymphology and Wound Care Unit, University of Szeged, Hungary
    Lymphology 40:138-42. 2007
    ..severe postoperative edema and pain, and operation on the third molar can cause local inflammation that impairs lymph transport...
  59. ncbi Total and differential leucocyte counts and lymphocyte subpopulations in lymph, afferent and efferent to the supramammary lymph node, during endotoxin-induced bovine mastitis
    S Lun
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Reprod Domest Anim 42:126-34. 2007
    Leucocyte trafficking in afferent and efferent mammary lymph and the supramammary lymph node in cows was examined during 4 h after intramammary infusion of endotoxin from Escherichia coli...
  60. ncbi Dendritic cells, implications on function from studies of the afferent lymph veiled cell
    C J Howard
    Institute for Animal Health, Near Newbury RG20 7NN, Compton, UK
    Vet Immunol Immunopathol 77:1-13. 2000
    Studies of afferent lymph veiled cells (ALVC) show that the full biological function of dendritic cells in peripheral tissue is not explained by a simple model in which immature dendritic cells at the body surface take up antigen, ..
  61. ncbi Lymph drainage studied by lymphoscintigraphy in the arms after sentinel node biopsy compared with axillary lymph node dissection following conservative breast cancer surgery
    F Celebioglu
    Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
    Acta Radiol 48:488-95. 2007
    To investigate lymphatic drainage as measured by lymphoscintigraphy in the arms of patients undergoing either sentinel lymph node biopsy (SNB) or axillary lymph node dissection (ALND).
  62. ncbi Intrinsic pump-conduit behavior of lymphangions
    Christopher M Quick
    College of Veterinary Medicine, 4466 Texas A and M University, College Station, TX 77843 4466, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1510-8. 2007
    ..They can act primarily like pumps when actively transporting lymph against a pressure gradient...
  63. pmc Effect of manual lymph drainage in addition to guidelines and exercise therapy on arm lymphoedema related to breast cancer: randomised controlled trial
    Nele Devoogdt
    Department of Rehabilitation Sciences, Katholieke Universiteit Leuven and Department of Physiotherapy, University Hospitals Leuven, Leuven, Belgium
    BMJ 343:d5326. 2011
    To determine the preventive effect of manual lymph drainage on the development of lymphoedema related to breast cancer.
  64. doi Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
    Zacarias Garcia
    Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
    Blood 120:4744-50. 2012
    ..virus Ankara vaccine in mice results in the accumulation of NK cells in the subcapsular area of the draining lymph node and their activation, a process that is strictly dependent on type I IFN signaling...
  65. doi [Lymphatic system: Anatomy, histology and physiology]
    Isabelle Quere
    CHU Saint Eloi, Universite de Montpellier I, centre de compétence maladies lymphatiques constitutionnelles, Service de Medecine Vasculaire, 34295 Montpellier Cedex 5, France
    Presse Med 39:1269-78. 2010
    ..This article provides an overview of current fundamental knowledge relating to lymphoedema based on both the historical anatomy description and the most recent data about lymphangiogenesis...
  66. pmc Determinants of valve gating in collecting lymphatic vessels from rat mesentery
    Michael J Davis
    Dept of Medical Pharmacology and Physiology, Univ of Missouri School of Medicine, 1 Hospital Dr, Rm M451, Columbia, MO 65212, USA
    Am J Physiol Heart Circ Physiol 301:H48-60. 2011
    Secondary lymphatic valves are essential for minimizing backflow of lymph and are presumed to gate passively according to the instantaneous trans-valve pressure gradient...
  67. ncbi Characteristics of the active lymph pump in bovine prenodal mesenteric lymphatics
    Anatoliy A Gashev
    Department of Systems Biology and Translational Medicine, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M Health Science Center, 336 Reynolds Medical Bldg, College Station, TX 77843 1114, USA
    Lymphat Res Biol 5:71-9. 2007
    ..We propose that the prenodal lymphatics have adapted to the local conditions of lymph flow and are functioning differently than the postnodal vessels.
  68. doi Engineered chylomicron mimicking carrier emulsome for lymph targeted oral delivery of methotrexate
    Rishi Paliwal
    Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr H S Gour Viswavidyalaya, Sagar 470003, MP, India
    Int J Pharm 380:181-8. 2009
    ..The in vivo studies were carried out on albino rats and response was estimated collecting blood and lymph both...
  69. ncbi Trauma-hemorrhagic shock mesenteric lymph from rat contains a modified form of albumin that is implicated in endothelial cell toxicity
    Vicki L Kaiser
    Department of Surgery, New Jersey Medical School, Newark, New Jersey
    Shock 23:417-25. 2005
    ..Indeed, it has been shown that lymph collected from shocked but not sham-shocked animals causes endothelial cell death, neutrophil activation, and bone ..
  70. ncbi Application of atmospheric pressure chemical ionization liquid chromatography-mass spectrometry in identification of lymph triacylglycerols
    H Mu
    Department of Biochemistry and Nutrition, Center for Advanced Food Studies, Technical University of Denmark, Lyngby
    J Chromatogr B Biomed Sci Appl 748:425-37. 2000
    ..liquid chromatography-mass spectrometry was used in the identification of triacylglycerol molecular species in lymph samples from rats given either a structured lipid or safflower oil...
  71. ncbi Clinical assessment of human lymph flow using removal rate constants of interstitial macromolecules: a critical review of lymphoscintigraphy
    S Modi
    Division of Cardiac and Vascular Sciences Dermatology, St George s Hospital Medical School, University of London, United Kingdom
    Lymphat Res Biol 5:183-202. 2007
    ..Lymphedema is by definition primarily a disease of impaired lymphatic drainage and lymph flow, and progress in lymphedema research, currently an increasingly active field, requires a clinically viable ..
  72. ncbi CD1a-positive dendritic cells transport the antigen DNCB intracellularly from the skin to the regional lymph nodes in the induction phase of allergic contact dermatitis
    R E Hunger
    Dermatological Clinic, University of Berne, Switzerland
    Arch Dermatol Res 293:420-6. 2001
    ..hypersensitivity reactions in animals dendritic cells have been reported to transport antigens to the regional lymph nodes...
  73. ncbi Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast
    C Chao
    Department of Surgery, Division of Surgical Oncology, J Graham Brown Cancer Center, University of Louisville School of Medicine, 315 E Broadway, Louisville, KY 40202, USA
    Am J Surg 182:307-11. 2001
    ..was performed in order to determine whether primary tumor location in breast cancer affects the axillary sentinel lymph node (SLN) identification (ID) rate, the false negative (FN) rate, incidence of axillary nodal metastases, or the ..
  74. ncbi Abdominal lymph flow in an endotoxin sepsis model: influence of spontaneous breathing and mechanical ventilation
    Marco Lattuada
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Crit Care Med 34:2792-8. 2006
    b>Lymph flow from the abdomen was investigated in a sepsis model...
  75. ncbi Long-term collection and characterization of afferent lymph from the ovine small intestine
    Wayne R Hein
    AgResearch Limited, Wallaceville Animal Research Centre, P O Box 40063, Ward Street, Upper Hutt, New Zealand
    J Immunol Methods 293:153-68. 2004
    Reliable methods for long-term collection of afferent lymph draining from the small intestine of sheep are described and validated...
  76. ncbi Mesenteric lymph from rats subjected to trauma-hemorrhagic shock are injurious to rat pulmonary microvascular endothelial cells as well as human umbilical vein endothelial cells
    E A Deitch
    Department of Surgery, UMDNJ-New Jersey Medical School, Newark 07103, USA
    Shock 16:290-3. 2001
    Previously, we have documented that gut-derived lymph from rats subjected to trauma/hemorrhagic shock (T/HS) is injurious to human umbilical vein endothelial cells (HUVEC)...
  77. ncbi Burn-induced impairment of cardiac contractile function is due to gut-derived factors transported in mesenteric lymph
    Justin T Sambol
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103, USA
    Shock 18:272-6. 2002
    ..Male rats were subjected to laparotomy with or without mesenteric lymph duct ligation (LDL)...
  78. ncbi Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption
    C A Adams
    Department of Surgery, UMD-New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 51:625-31; discussion 631-2. 2001
    BACKGROUND: Previous studies have shown that mesenteric lymph duct interruption prevents lung injury and decreases lung neutrophil sequestration after hemorrhagic shock (HS)...
  79. ncbi Molecular and functional analyses of the contractile apparatus in lymphatic muscle
    Mariappan Muthuchamy
    Department of Medical Physiology, Cardiovascular Research Institute, College of Medicine Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    FASEB J 17:920-2. 2003
    Lymphatics are necessary for the generation and regulation of lymph flow. Lymphatics use phasic contractions and extrinsic compressions to generate flow; tonic contractions alter resistance...
  80. ncbi Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome
    Stacey D Moore-Olufemi
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Shock 23:571-5. 2005
    ..secondary (2 degrees) intra-abdominal hypertension (IAH) on hemodynamics, intestinal fluid balance, and mesenteric lymph flow...
  81. pmc Trauma-hemorrhagic shock mesenteric lymph induces endothelial apoptosis that involves both caspase-dependent and caspase-independent mechanisms
    Marson T Davidson
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    Ann Surg 240:123-31. 2004
    To determine the mechanism by which gut-derived factors present in mesenteric lymph from rats subjected to trauma-hemorrhagic shock (T/HS) induce endothelial cell death.
  82. pmc Postshock mesenteric lymph induces endothelial NF-kappaB activation
    Sagar S Damle
    University of Colorado at Denver, Health Sciences Center, Denver, Colorado 80204, USA
    J Surg Res 143:136-40. 2007
    Posthemorrhagic shock mesenteric lymph (PSML) has been shown to activate pulmonary endothelial cells and cause lung injury...
  83. pmc Gelsolin is depleted in post-shock mesenteric lymph
    Janeen R Jordan
    Department of Surgery, University of Colorado Health Science, Denver, Colorado 80204, USA
    J Surg Res 143:130-5. 2007
    ..We have previously shown that following hemorrhagic shock with splanchnic hypoperfusion, mesenteric lymph contains lipid components that cause neutrophil and EC activation and that protein concentrations are severely ..
  84. ncbi Influence of gut microflora on mesenteric lymph cytokine production in rats with hemorrhagic shock
    Weidun Guo
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Trauma 52:1178-85; disciussion 1185. 2002
    ..The aim of the present study was to test the hypothesis that the resident gut microflora play a role in modulating gut cytokine production under normal circumstances and in response to tissue injury with or without hemorrhagic shock...
  85. doi Quantitative lymph imaging for assessment of lymph function using indocyanine green fluorescence lymphography
    N Unno
    Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Eur J Vasc Endovasc Surg 36:230-6. 2008
    A new diagnostic imaging technique that can assess lymph function is needed as a screening test in daily practice. This study assessed the use of indocyanine green (ICG) fluorescence lymphography in subjects without leg oedema.
  86. doi The proteome of rodent mesenteric lymph
    Anubhav Mittal
    School of Biological Sciences, Univ of Auckland, Auckland 1023, New Zealand
    Am J Physiol Gastrointest Liver Physiol 295:G895-903. 2008
    Mesenteric lymph contributes to normal homeostasis and has an emerging role in the pathogenesis of multiple organ dysfunction syndrome...
  87. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    ..using B16-F10 melanoma cells implanted in syngeneic C57Bl/6 mice, which form tumors metastasizing to draining lymph nodes and subsequently to the lungs...
  88. ncbi Lymphatic smooth muscle: the motor unit of lymph drainage
    Pierre Yves von der Weid
    Mucosal Inflammation and Smooth Muscle Research Groups, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Int J Biochem Cell Biol 36:1147-53. 2004
    ..Their intrinsic contractile property--the intrinsic lymph pump--through rhythmical and phasic contractions of the vessels, represents the principal mechanism by which lymph ..
  89. ncbi Lung ventilation contributes to vertical lymph movement in anurans
    Michael S Hedrick
    Department of Biological Sciences, California State University, East Bay, Hayward, CA 94542, USA
    J Exp Biol 210:3940-5. 2007
    ..b>Lymph is ultimately pumped into the venous system by paired, dorsally located lymph hearts...
  90. ncbi Structure and function of rat lymph nodes
    Osamu Ohtani
    Department of Anatomy, Faculty of Medicine and Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Arch Histol Cytol 71:69-76. 2008
    The lymph node comprises a critical crossroad for encounters between antigen presenting cells, antigens from lymph, and lymphocytes recruited into lymph nodes from the blood...
  91. doi Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration
    Asolina Braun
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Nat Immunol 12:879-87. 2011
    Little is known about the molecular mechanisms that determine the entry into the lymph node and intranodal positioning of lymph-derived cells...
  92. ncbi Pathophysiological aspects of lymphedema of human limbs: I. Lymph protein composition
    Waldemar L Olszewski
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Lymphat Res Biol 1:235-43. 2003
    The knowledge of humoral and cellular factors retained in tissues affected by ineffective lymph transport is necessary to comprehend the pathological mechanisms of the evolving changes in the extremity...
  93. ncbi Phenotypic diversity of antigen-presenting cells in ovine-afferent intestinal lymph
    Anton Pernthaner
    AgResearch Limited, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Arch Med Res 33:405-12. 2002
    ..life history, when these cells leave peripheral tissues and travel via afferent lymphatic vessels to regional lymph nodes...
  94. doi Modeling flow in collecting lymphatic vessels: one-dimensional flow through a series of contractile elements
    A J MacDonald
    School of Engineering, Computer Science and Mathematics, Univ of Exeter, Exeter, UK
    Am J Physiol Heart Circ Physiol 295:H305-13. 2008
    ..The computational model is able to reproduce the pumping behavior of the real vessel using a simple contraction function producing fast contraction pulses traveling in the retrograde direction to the flow...
  95. ncbi Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock
    J M Adams
    Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 29:2194-8. 2001
    ..T/HS mesenteric lymph injures endothelial cell and lymph duct ligation (LDL) before T/HS prevents pulmonary injury...
  96. ncbi [Functional anatomy of the lymphatic drainage of the breast: contribution of sentinel lymph node biopsy]
    J B Olivier
    Departement de Chirurgie, Centre Alexis Vautrin, Avenue de Bourgogne, 54500 Vandoeuvre les Nancy, France
    Ann Chir 131:608-15. 2006
    ..of the literature concerning the functional anatomy of the lymphatic drainage of the breast, observed during interventions of sentinel lymph node biopsy; to compare the descriptive anatomy taking into consideration these new results.
  97. doi First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions
    Christopher M Quick
    Michael E DeBakey Institute, Texas A and M University, College Station, TX 77843 4466, USA
    Am J Physiol Heart Circ Physiol 294:H2144-9. 2008
    To return lymph to the great veins of the neck, it must be actively pumped against a pressure gradient...
  98. ncbi Relationship between lymph and tissue hyaluronan in skin and skeletal muscle
    Shayn E Armstrong
    Center for Cardiovascular Sciences, Albany Medical College, New York 12208 3479, USA
    Am J Physiol Heart Circ Physiol 283:H2485-94. 2002
    The size of hyaluronan was compared between tissue and lymph using a combination of agarose gel electrophoresis and radiometric assay. Prenodal lymph was collected from heel skin and the gastrocnemius muscle in anesthetized rabbits...
  99. ncbi The proteome of mesenteric lymph during acute pancreatitis and implications for treatment
    Anubhav Mittal
    Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    JOP 10:130-42. 2009
    The protein fraction of mesenteric lymph during acute pancreatitis and other critical illness is thought to contain toxic factors. However, we do not have a complete description of the mesenteric lymph proteome during acute pancreatitis.
  100. pmc Proteome and system ontology of hemorrhagic shock: exploring early constitutive changes in postshock mesenteric lymph
    Erik D Peltz
    Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO 80204, USA
    Surgery 146:347-57. 2009
    Postshock mesenteric lymph (PSML) is the mechanistic link between splanchnic ischemia reperfusion (IR) and remote organ injury...
  101. ncbi Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1 alpha secretion
    J C Hope
    Institute for Animal Health, Newbury, Berkshire, United Kingdom
    J Leukoc Biol 69:271-9. 2001
    The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRP alpha MyD-1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation...

Research Grants81

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..scientific peer review panel in 2008 and 2009 to review several new versions and applications of the murine local lymph node assay (LLNA), an alternative test method for assessing the allergic contact dermatitis potential of chemicals ..
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..scientific peer review panel in 2008 and 2009 to review several new versions and applications of the murine local lymph node assay (LLNA), an alternative test method for assessing the allergic contact dermatitis potential of chemicals ..
  3. Yasmin Wadia; Fiscal Year: 2014
    ..technology to join and seal tissues for controlling the leakage of blood, gastrointestinal fluids, urine, bile, lymph, and cerebrospinal fluid...
  4. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..of memory B cells in peripheral blood, broncho-alveolar lavage (BAL), bone marrow (BM), small intestine and lymph node tissues from SIV infected macaques...
  5. Norma S Kenyon; Fiscal Year: 2015
    ..e., the graft site) and migration of MSC to lymph nodes draining the graft site...
  6. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..We have identified a new gene, zfrp8, controlling cell proliferation of the hematopoietic organs, the lymph glands...
  7. PAUL CAMILLE TUMEH; Fiscal Year: 2015
    ..the stratum corneum, deliver, and release the payload to the epidermal LCs, and track loaded LC migration to the lymph node in vivo...
  8. Rinn Song; Fiscal Year: 2016
    ..Adding culture of lymph node aspirates to this improves sensitivity but still omits many cases with consistent radiology and response to ..
  9. DANIEL J CARR; Fiscal Year: 2015
    ..Moreover, there is a massive loss of cells residing in the draining lymph node associated with an increase in T cell apoptosis and necrosis...
  10. JAMES M COGHILL; Fiscal Year: 2015
    ..principal investigatorof the present proposal, published animal model data showing that donor cells lacking the lymph node trafficking receptor CC-Chemokine receptor 7 (CCR7) generate greatly attenuated GVHD responses when ..
  11. Brian F Volkman; Fiscal Year: 2016
    ..20 cancer types express CXCR4 and metastasize to tissues that secrete SDF1, including bone marrow, lung, liver and lymph nodes...
  12. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..a role in induction of Th1 immunity against influenza and HSV-1 and are recruited in mouse infection models to lymph nodes to stimulate antiviral cytotoxic T-cells...
  13. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..directly infected with HIV- 1, or become infected after interaction with infected APC, then migrate to adjacent lymph nodes, leading to the transmission of HIV-1 from mucosal sites to the periphery...
  14. Tibor T Glant; Fiscal Year: 2014
    ..Selected genes will be tested for their expression in arthritic joints and joint-draining lymph nodes, sequenced, and their in vivo (arthritis-affecting) function will be tested in either knockout or IVSC mice, ..
  15. PEARLIE K BURNETTE; Fiscal Year: 2016
    ..We show in preliminary results that the lymph node homing receptor L-selectin (CD62L) is dramatically lost from CD8+ T cells in LGL leukemia patients (..
  16. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    b>Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
  17. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..positives drive up the cost of healthcare with unnecessary, expensive, and invasive procedures (including sentinel lymph node biopsy and systemic adjuvant therapy) and may make it impossible for the patient to obtain health or life ..
  18. Hardy Kornfeld; Fiscal Year: 2016
    ..of myeloid cells around Mtb-infected alveolar macrophages (AMF) and slow to deliver bacilli to the thoracic lymph nodes (TLN) where immunity is primed...
  19. Henryk F Urbanski; Fiscal Year: 2014
    ..the homeostasis of tissue resident lymphocytes by determining 1) T and B cell subset distribution in bone marrow, lymph nodes, bronchoalveolar lavage, and gut biopsies;and 2) the cytokine milieu of these tissues...
  20. Sienmi Du; Fiscal Year: 2014
    ..previously focused on generation of immune responses in EAE and showed that the transfer of PLP 139-151 sensitized lymph node cells with XX sex chromosome complement leads to greater disease severity than cells with XY- complement...
  21. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..These exogenously administered lung SP cells were found in the lung associated lymph nodes and parenchyma...
  22. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lymphatic vascular cell traffic from the periphery to lymph nodes occurs during both inflammatory responses as well as neoplasia...
  23. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..production, poly(ADP-ribose)polymerase formation, and gross and histologic injury scores, and on draining lymph node populations of Th1 and Treg lymphocytes...
  24. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..distribution of pStat3, IL-6 and NF-kB and leukocyte infiltration in archived breast cancer samples with matched lymph nodes and distant metastasis...
  25. Lih Yun Hsu; Fiscal Year: 2016
    ..compare YYAA and SKG mouse TCR repertoires of the infiltrating T cells in the joints and peripheral T cells from lymph nodes...
  26. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lymph nodes are the initial sites of metastasis for most solid tumors, including breast carcinoma and melanoma...
  27. Matthew B Grisham; Fiscal Year: 2015
    ..We hypothesize that ex vivo-generated MSCs home to the mesenteric lymph nodes (MLNs) and/or colonic lamina propria where they prevent/limit gut inflammation directly via their production ..
  28. JAMES ALAN SHAYMAN; Fiscal Year: 2014
    ..The spleens and lymph nodes are characterized by the persistence of high levels of apoptotic bodies in association with resident ..
  29. Howard E Gendelman; Fiscal Year: 2016
    ..This will include measures of BBB penetrance and tissue drug levels in brain, spleen, lymph nodes, and liver. Histologic and imaging assays will evaluate potential drug toxicities...
  30. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..Upon inhalation, the Anthrax spores adhere to the alveolar macrophages and germinate. Bacteria migrate to the lymph node, in which they rapidly multiply and excrete a tripartite exotoxin comprised of protective antigen (PA), ..
  31. Adam Lin; Fiscal Year: 2014
    ..larger in size (>100nm in diameter) and tend to stay at injection sites while smaller nanoparticles drain into lymph nodes with subcutaneous injections. They also have known toxicities post degradation...
  32. Sally S Twining; Fiscal Year: 2014
    ..The Specific Objectives are: 1) To test the hypothesis that maspin alters heme and lymph-angiogenesis by multiple mechanisms involving both direct effects on vascular and lymph endothelial cells and ..
  33. Immune Mechanisms That Control Ectromelia Virus Infection
    Luis J Sigal; Fiscal Year: 2013
    ..immunity by examining the mechanisms by which type 1 interferons limit spread of the virus beyond the draining lymph node...
  34. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..Evidence suggests that cells infiltrating the lung early during infection transport antigen to the lymph nodes which contributes to the initiation of adaptive immunity...
  35. Dan Littman; Fiscal Year: 2016
    ..of an appropriate T cell repertoire;it is essential for the differentiation of Lti cells that induce formation of lymph nodes and Peyer's patches in the fetus and of cryptopatches and isolated lymphoid follicles in the post-natal ..
  36. TOMASZ K KORDULA; Fiscal Year: 2016
    ..MS symptoms, in part, by downregulating S1P1 on lymphocytes thus preventing their S1P-dependent egress from the lymph nodes...
  37. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..a drug delivery system to improve tissue penetrance of ART into the reticuloendothelial system (RES;spleen, liver, lymph nodes) in mice...
  38. Regulatory targets and pathogenic mechanisms of anthrax edema factor
    Jin Mo Park; Fiscal Year: 2011
    ..anthracis-infected macrophages to lymph nodes and spreading of the bacterium to the blood circulation...
  39. Souheil El-Chemaly; Fiscal Year: 2014
    ..g. by promoting antigen presentation within draining lymph nodes and stimulating alloimmune responses)...
  40. Reza Dana; Fiscal Year: 2016
    ..significantly enhanced capacity of alloantigen-bearing antigen- presenting cells (APC) to gain access to regional lymph nodes;(ii) allosensitization is enhanced in the high- risk transplant setting due to graft bed microenvironment ..
  41. Hesham M Amin; Fiscal Year: 2015
    ..Patients typically present with advanced-stage disease and generalized involvement of the lymph nodes and other organs including skin, bone marrow, and liver...
  42. Jacki Kornbluth; Fiscal Year: 2015
    ..compared with WT after injection with B16 melanoma cells and show greater dissemination of lymphoma cells to lymph nodes from the primary tumor site. Finally, a critical finding is that NKLAM functions as an E3 ubiquitin ligase...
  43. Bruce R Blazar; Fiscal Year: 2016
    ..Key findings late post-BMT include: 1. Small lymph nodes (LNs) and disorganized microarchitecture;2...
  44. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
    ..confirmation by fine needle biopsy does not give a representative evaluation of the entire prostate or determine lymph node involvement...
  45. SAGAR PRADEEP BAPAT; Fiscal Year: 2014
    ..study showed that fTregs have a different gene expression signature compared to Tregs isolated from the spleen or lymph nodes in mice...
  46. Treatment of breast cancer tumor growth and metastasis with an anti-MMP-9 DNAzyme
    MIRANDA A HALLETT; Fiscal Year: 2011
    ..Breast cancer metastasizes to brain, lung, bone, liver and regional lymph nodes. Early detection and advancements in research have increased survival and enhanced quality of life...
  47. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..Furthermore, suppression of S1PR1 signaling by FTY720 has negative effect on CXCR4-mediated lymph node egress...
  48. Immunomodulation in melanoma therapy
    NOAH A CRAFT; Fiscal Year: 2012
    ..TLR7 leads to activation, maturation, and migration of dendritic cells (DCs) to the tumor site and to the draining lymph nodes...
  49. Timothy W Schacker; Fiscal Year: 2014
    ..We will measure changes in levels of collagen in LT, changes in CD4+ T cell populations in peripheral blood and lymph node, and functional assessments of immunity with primary and recall responses to antigens...
  50. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..and TNFSF11), a member of the TNF superfamily previously shown to have obligatory roles in the development of lymph nodes, the differentiation of medullary thymic epithelial cells, the differentiation of osteoclasts, and mammary ..
  51. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..In vivo, DC-SIGN- positive cells were demonstrated in lymph nodes, tonsils, skin, and the subepithelial region of the cervix...
  52. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas M Moran; Fiscal Year: 2010
    ..Our data suggests that the bone marrow derived monocytes migrate to the draining lymph nodes and participate in both innate and adaptive immunity...
  53. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..All women undergoing breast cancer treatment are at lifetime risk for LE. While removal of lymph nodes, surgery, and radiation are the major causal factors for LE, cancer treatment is necessary for life-saving...
  54. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    Lymphocytes home from the blood into lymph nodes during the process of lymphocyte recirculation. Homing is initiated by the rolling of lymphocytes on high endothelial venules (HEVs) within the lymph node...
  55. Patrick Tso; Fiscal Year: 2015
    ..In our well established conscious lymph fistula rats, we showed that fat absorption activates the intestinal mucosal mast cells (MMC) and they degranulate ..
  56. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..exposure of New Zealand White rabbits to the isolate resulted in severe eye disease and necrosis of the spleen and lymph nodes...
  57. Kaustubh Datta; Fiscal Year: 2014
    ..three hundred patients with locally invasive prostate cancer and prostate cancer with metastases in the regional lymph nodes. The role of downstream targets of VEGF-C (e.g...
  58. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..We found that these T cells underwent massive expansion in the spleen and lymph nodes following intragastric infection, uniformly differentiated into [unreadable]multifunctional[unreadable] IFN-&..
  59. Effector and Memory Anti-Malaria CD8+ Cell Responses
    FIDEL P ZAVALA; Fiscal Year: 2013
    ..are delivered by mosquito bites, the T cell response is induced by dendritic cells (DCs) in skin draining lymph nodes (LN)...
  60. Donna L Farber; Fiscal Year: 2016
    ..T cells from blood and eight different tissues including lymphoid tissues (spleen, peripheral and tissue-draining lymph nodes), and mucosal tissues (lung, small and large intestines) from over 24 research-consented, previously healthy ..
  61. Michelle H Larsen; Fiscal Year: 2014
    ..the rapid induction of antiviral immunity in local tissues of the oral and intestinal mucosa and their draining lymph nodes...
  62. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2013
    ..They will assess the extent to which migration of virus-specific B cells/plasma cells from regional lymph nodes is required for the establishment of lung tissue plasma cell pools, and using genetic screening and a custom ..
  63. JENS MARC TITZE; Fiscal Year: 2016
    ..VEGF-C promotes interstitial electrolyte clearance through the cutaneous lymph capillary network...
  64. MASSAGE THERAPY FOR EXPERIMENTAL LYMPHEDEMA
    Marlys Witte; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): Massage therapy (in the form of Manual Lymph Drainage (MLD) or Manual Lymphedema Treatment (MLT) is an integral component of the international consensus-recommended optimal treatment for lymphedema(LE)..
  65. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..with lymphotoxin-beta receptor (LTbR)-Ig do not develop Peyer's patches ; however, these mice exhibit mesenteric lymph nodes which drain the small intestine...
  66. SURGERY AND IV NUTRITION MODULATE MACROPHAGE FUNCTION
    W Helton; Fiscal Year: 1999
    ..Mphis will be isolated from the mesenteric lymph nodes, peritoneal cavity, lung, and spleen and their function studied...
  67. XENOGENEIC MODEL FOR HOMING OF HUMAN LYMPHOCYTES
    Sharon Evans; Fiscal Year: 1993
    ..Lymphocyte migration into peripheral lymph nodes is initiated by the interaction of the L-selectin homing receptor on lymphocytes with the vascular addressin ..
  68. Fluorescence Imaging for Sentinel Lymph Node Mapping
    Eva Sevick Muraca; Fiscal Year: 2003
    Biopsy of the sentinel lymph node provides a convenient prognostic indicator for breast cancer, melanoma, as well as other cancers...
  69. Endoscopic Detection of Fluorescein for Sentinel Lymph Node Biopsy
    James McGreevy; Fiscal Year: 2007
    ..This new device will allow the surgeon to perform the axillary dissection of lymph nodes in breast cancer patients with minimally-invasive surgical techniques...
  70. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    Lymphocytes "home" from the blood into lymph nodes as part of the process of lymphocyte recirculation. This homing process has multiple steps consisting of a sequence of adhesive and signaling interactions...
  71. LCDIO FOR LYMPH NODE MR IMAGING
    Ralph Weissleder; Fiscal Year: 2001
    ..dextran based iron oxide (LCDIO) contrast agents for the assessment of active tumor growth in local and regional lymph nodes during cancer spread...
  72. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..The presence of metastatic disease in the mediastinal lymph nodes of NSCLC patients has profound prognostic and therapeutic implications...
  73. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2002
    ..The presence of metastatic disease in the mediastinal lymph nodes of NSCLC patients has profound prognostic and therapeutic implications...
  74. HIV Evasion of NK Cells in Lymph Nodes
    Allan R Tenorio; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): A major site for productive HIV infection is the lymph node...