neocortex

Summary

Summary: The largest portion of the CEREBRAL CORTEX. It is composed of NEURONS arranged in six layers.

Top Publications

  1. ncbi Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    Nat Methods 1:31-7. 2004
  2. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
  3. doi Neurogenic radial glia in the outer subventricular zone of human neocortex
    David V Hansen
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, California 94143, USA
    Nature 464:554-561. 2010
  4. pmc Development and evolution of the human neocortex
    Jan H Lui
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA
    Cell 146:18-36. 2011
  5. pmc Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
    Anthony Holtmaat
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA
    Nat Protoc 4:1128-44. 2009
  6. pmc Evolution of the neocortex: a perspective from developmental biology
    Pasko Rakic
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 10:724-35. 2009
  7. pmc miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 135:3911-21. 2008
  8. doi Experimental evidence for sparse firing in the neocortex
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:345-55. 2012
  9. pmc Dense inhibitory connectivity in neocortex
    Elodie Fino
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 69:1188-203. 2011
  10. doi Schema-dependent gene activation and memory encoding in neocortex
    Dorothy Tse
    Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Science 333:891-5. 2011

Research Grants

  1. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
  2. Pat Levitt; Fiscal Year: 2016
  3. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
  4. Arnold Kriegstein; Fiscal Year: 2014
  5. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
  6. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
  7. KRISTIN GIAMANCO; Fiscal Year: 2015
  8. Robert A Sweet; Fiscal Year: 2016
  9. Kimberly Huber; Fiscal Year: 2016
  10. XIANJIN ZHOU; Fiscal Year: 2014

Detail Information

Publications412 found, 100 shown here

  1. ncbi Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    Nat Methods 1:31-7. 2004
    ..Here, we describe a new, highly selective approach for labeling astrocytes in intact rodent neocortex that allows in vivo imaging using two-photon microscopy...
  2. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a ..
  3. doi Neurogenic radial glia in the outer subventricular zone of human neocortex
    David V Hansen
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, California 94143, USA
    Nature 464:554-561. 2010
    ..The establishment of non-ventricular radial glia-like cells may have been a critical evolutionary advance underlying increased cortical size and complexity in the human brain...
  4. pmc Development and evolution of the human neocortex
    Jan H Lui
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA
    Cell 146:18-36. 2011
    ..Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), ..
  5. pmc Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
    Anthony Holtmaat
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA
    Nat Protoc 4:1128-44. 2009
    ..The entire dendritic and axonal arbor of individual neurons can be reconstructed...
  6. pmc Evolution of the neocortex: a perspective from developmental biology
    Pasko Rakic
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 10:724-35. 2009
    The enlargement and species-specific elaboration of the cerebral neocortex during evolution holds the secret to the mental abilities of humans; however, the genetic origin and cellular mechanisms that generated the distinct evolutionary ..
  7. pmc miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 135:3911-21. 2008
    ..the possible role of microRNAs (miRNAs) in this process, we conditionally ablated Dicer in the developing mouse neocortex using Emx1-Cre, which is specifically expressed in the dorsal telencephalon as early as embryonic day (E) 9.5...
  8. doi Experimental evidence for sparse firing in the neocortex
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:345-55. 2012
    ..Superficial layers of the cortex may employ specific cell and circuit mechanisms to increase sparseness...
  9. pmc Dense inhibitory connectivity in neocortex
    Elodie Fino
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 69:1188-203. 2011
    ..We conclude that local inhibitory connectivity is promiscuous, does not form subnetworks, and can approach the theoretical limit of a completely connected synaptic matrix...
  10. doi Schema-dependent gene activation and memory encoding in neocortex
    Dorothy Tse
    Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Science 333:891-5. 2011
    ..These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas...
  11. doi Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer subventricular zone progenitors
    Atsunori Shitamukai
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Neurosci 31:3683-95. 2011
    ..We also found a small endogenous population of outer VZ progenitors in the mouse embryonic neocortex, consistent with a low frequency of oblique radial glia divisions...
  12. ncbi Neurogenesis in the neocortex of adult primates
    E Gould
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Science 286:548-52. 1999
    ..The new neurons appeared to originate in the subventricular zone and to migrate through the white matter to the neocortex, where they extended axons...
  13. ncbi Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
    Hiroaki Fukumoto
    Alzheimer Disease Research Unit, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital East, Bldg 114, Room 2010, 114 16th Street, Charlestown, MA 02129, USA
    Arch Neurol 59:1381-9. 2002
    ....
  14. ncbi Absence of rapid sensory adaptation in neocortex during information processing states
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuron 41:455-64. 2004
    One prominent feature of sensory responses in neocortex is that they rapidly adapt to increases in frequency, a process called "sensory adaptation...
  15. pmc Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus
    Iva Kelava
    Max Planck Institute of Molecular Cell Biology and Genetics, D 01307 Dresden, Germany
    Cereb Cortex 22:469-81. 2012
    Subventricular zone (SVZ) progenitors are a hallmark of the developing neocortex. Recent studies described a novel type of SVZ progenitor that retains a basal process at mitosis, sustains expression of radial glial markers, and is ..
  16. pmc Shaping our minds: stem and progenitor cell diversity in the mammalian neocortex
    Santos J Franco
    Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 77:19-34. 2013
    The neural circuits of the mammalian neocortex are crucial for perception, complex thought, cognition, and consciousness. This circuitry is assembled from many different neuronal subtypes with divergent properties and functions...
  17. ncbi Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
    ..We describe this feedback pathway and propose it as a central mechanism for regulation of cortical activity...
  18. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009
    ..These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex.
  19. doi OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
    Simone A Fietz
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Nat Neurosci 13:690-9. 2010
    ..We found that progenitors in the outer SVZ (OSVZ) of developing human neocortex retain features of radial glia, in contrast to rodent SVZ progenitors, which have limited proliferation ..
  20. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    ..In view of the high firing rates in the functionally disconnected state of slow-wave sleep, we suggest that neocortical neurons are engaged in processing internally generated signals...
  21. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  22. pmc Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons
    Scott J Cruikshank
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 65:230-45. 2010
    Thalamocortical and corticothalamic pathways mediate bidirectional communication between the thalamus and neocortex. These pathways are entwined, making their study challenging...
  23. pmc Rapid neocortical dynamics: cellular and network mechanisms
    Bilal Haider
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neuron 62:171-89. 2009
    ..This basic operating principle of the neocortex is mediated by the continuously changing flow of excitatory and inhibitory synaptic barrages that not only ..
  24. doi Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons
    Yoanne M Clovis
    Department of Neuroscience and Brain Technologies, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
    Development 139:3332-42. 2012
    ..miRNA depletion and in vivo target validation as a strategy to identify novel miRNA targets in embryonic mouse neocortex. By this means, we find that Foxp2, a transcription factor associated with speech and language development and ..
  25. doi Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex
    Olga Britanova
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Neuron 57:378-92. 2008
    Pyramidal neurons of the neocortex can be subdivided into two major groups: deep- (DL) and upper-layer (UL) neurons...
  26. doi Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex
    Reut Shema
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 331:1207-10. 2011
    ..Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mζ (PKMζ) enhances long-term memory, whereas a dominant ..
  27. ncbi Synaptic connections and small circuits involving excitatory and inhibitory neurons in layers 2-5 of adult rat and cat neocortex: triple intracellular recordings and biocytin labelling in vitro
    Alex M Thomson
    Department of Physiology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Cereb Cortex 12:936-53. 2002
    Dual and triple intracellular recordings with biocytin labelling in slices of adult neocortex explored small circuits of synaptically connected neurons...
  28. ncbi Gap junction adhesion is necessary for radial migration in the neocortex
    Laura A B Elias
    Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nature 448:901-7. 2007
    ....
  29. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    ..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
  30. pmc An embedded subnetwork of highly active neurons in the neocortex
    Lina Yassin
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuron 68:1043-50. 2010
    Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity...
  31. pmc Comparative analysis of the subventricular zone in rat, ferret and macaque: evidence for an outer subventricular zone in rodents
    Veronica Martinez-Cerdeno
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 7:e30178. 2012
    ..regulate cortical neurogenesis and may point toward mechanisms that underlie the evolutionary expansion of the neocortex in gyrencephalic mammals...
  32. pmc Updated energy budgets for neural computation in the neocortex and cerebellum
    Clare Howarth
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Cereb Blood Flow Metab 32:1222-32. 2012
    ..The majority of cerebellar signaling energy use is on the maintenance of resting potentials (54%) and postsynaptic receptors (22%), while action potentials account for only 17% of the signaling energy use...
  33. pmc Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex
    Jerry L Chen
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 74:361-73. 2012
    ..Our findings provide in vivo evidence for local coordination of inhibitory and excitatory synaptic rearrangements...
  34. pmc Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex
    Erika E Fanselow
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1458 Thomas E Starzl Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 100:2640-52. 2008
    ..Because GIN cells are more readily activated than RS and FS cells, it is possible that they act as "first responders" when cortical excitatory activity increases...
  35. pmc Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex
    Christian Wozny
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Cereb Cortex 21:1818-26. 2011
    ..Here, we investigate the electrophysiological properties of layer 1 (L1) neurons of the rat somatosensory neocortex (postnatal day 24-36) and their synaptic connectivity with supragranular pyramidal neurons...
  36. pmc Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex
    Francesco Bedogni
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 107:13129-34. 2010
    ..Similar to Sox5 mutants, Tbr1 mutants exhibit ectopic axon projections to the hypothalamus and cerebral peduncle. Together, our findings show that Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons...
  37. pmc Transcriptional architecture of the primate neocortex
    Amy Bernard
    Allen Institute for Brain Science, Seattle, WA 98103, USA
    Neuron 73:1083-99. 2012
    ..These data provide a unique resource detailing neocortical transcription patterns in a nonhuman primate with great similarity in gene expression to human...
  38. pmc Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex
    Maria Pia Postiglione
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Neuron 72:269-84. 2011
    Neurons in the mammalian neocortex arise from asymmetric divisions of progenitors residing in the ventricular zone...
  39. ncbi The high-conductance state of neocortical neurons in vivo
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Nat Rev Neurosci 4:739-51. 2003
  40. pmc Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice
    Yunyong Ma
    Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506, USA
    J Neurosci 26:5069-82. 2006
    ..We conclude that much of the variability previously attributed to neocortical SOM+ interneurons can be accounted for by their natural grouping into distinct subtypes...
  41. ncbi Neocortex patterning by the secreted signaling molecule FGF8
    T Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 294:1071-4. 2001
    A classic model proposes that the mammalian neocortex is divided into areas early in neurogenesis, but the molecular mechanisms that generate the area map have been elusive...
  42. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
    ..Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability...
  43. ncbi Coordinated reactivation of distributed memory traces in primate neocortex
    K L Hoffman
    Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA
    Science 297:2070-3. 2002
    ..form may involve the gradual refinement and linking together of neural representations stored widely throughout neocortex. This consolidation process may require coordinated reactivation of distributed components of memory traces ..
  44. ncbi Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 90:2987-3000. 2003
    Normal operations of the neocortex depend critically on several types of inhibitory interneurons, but the specific function of each type is unknown...
  45. pmc Specific synapses develop preferentially among sister excitatory neurons in the neocortex
    Yong Chun Yu
    Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue, USA
    Nature 458:501-4. 2009
    Neurons in the mammalian neocortex are organized into functional columns...
  46. ncbi Internal dynamics determine the cortical response to thalamic stimulation
    Jason N MacLean
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Neuron 48:811-23. 2005
    Although spontaneous activity occurs throughout the neocortex, its relation to the activity produced by external or sensory inputs remains unclear...
  47. ncbi Is neocortex essentially multisensory?
    Asif A Ghazanfar
    Program in Neuroscience, Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey, 08540, USA
    Trends Cogn Sci 10:278-85. 2006
    ..Indeed, the multisensory nature of most, possibly all, of the neocortex forces us to abandon the notion that the senses ever operate independently during real-world cognition.
  48. pmc A new subtype of progenitor cell in the mouse embryonic neocortex
    Xiaoqun Wang
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA
    Nat Neurosci 14:555-61. 2011
    ..appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex...
  49. doi The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex
    Katsutoshi Sekine
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Neurosci 31:9426-39. 2011
    Mammalian neocortex has a laminated structure that develops in a birth-date-dependent "inside-out" pattern...
  50. pmc Clonal production and organization of inhibitory interneurons in the neocortex
    Keith N Brown
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Science 334:480-6. 2011
    The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits...
  51. pmc Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
    Kenneth Y Kwan
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Development 139:1535-46. 2012
    The cerebral neocortex is segregated into six horizontal layers, each containing unique populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons and inhibitory interneurons...
  52. pmc The spatial and temporal origin of chandelier cells in mouse neocortex
    Hiroki Taniguchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 339:70-4. 2013
    ..They migrate with stereotyped routes and schedule and achieve specific laminar distribution in the cortex. The developmental specification of this bona fide interneuron type likely contributes to the assembly of a cortical circuit motif...
  53. ncbi Activity of midbrain reticular formation and neocortex during the progression of human non-rapid eye movement sleep
    N Kajimura
    National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry NCNP, Kodaira 187 8551, Japan
    J Neurosci 19:10065-73. 1999
    ..decreased in the left medial frontal gyrus, left inferior frontal gyrus, and left inferior parietal gyrus of the neocortex. During deep NREM sleep, the rCBF in the midbrain tegmentum decreased, and there was a marked and bilateral ..
  54. ncbi Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex
    Ryohei Tomioka
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Eur J Neurosci 21:1587-600. 2005
    Gamma-aminobutyric acid (GABA)ergic neurons in the neocortex have been mainly regarded as interneurons and thought to provide local interactions...
  55. ncbi Recurrent neuronal circuits in the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, Winterthurerstrasse 190, Zurich, Switzerland
    Curr Biol 17:R496-500. 2007
  56. pmc Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:479-89. 2008
    ....
  57. pmc Quantal analysis reveals a functional correlation between presynaptic and postsynaptic efficacy in excitatory connections from rat neocortex
    Neil R Hardingham
    The University Laboratory of Physiology, Oxford University, Oxford, OX1 3PT, United Kingdom
    J Neurosci 30:1441-51. 2010
    ..The efficacy of a cortical connection is thus set by coordinated presynaptic and postsynaptic strength...
  58. doi Selective gene expression in regions of primate neocortex: implications for cortical specialization
    Tetsuo Yamamori
    Brain Biology, National Institute for Basic Biology, The Graduate University for Advanced Studies Sokendai, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444 8585, Japan
    Prog Neurobiol 94:201-22. 2011
    The neocortex, which is characteristic of mammals, has evolved to play important roles in cognitive and perceptual functions...
  59. ncbi Fast-spike interneurons and feedforward inhibition in awake sensory neocortex
    Harvey A Swadlow
    Department of Psychology, The University of Connecticut, Storrs, CT 06269, USA
    Cereb Cortex 13:25-32. 2003
    ..This fast, synchronous, highly sensitive and broadly tuned feed-forward inhibitory network is well suited to suppress spike generation in spiny neurons following all but the most optimal feedforward excitatory inputs...
  60. ncbi Interlaminar connections in the neocortex
    Alex M Thomson
    Department of Physiology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Cereb Cortex 13:5-14. 2003
    This review summarizes the local circuit, interlaminar connections in adult mammalian neocortex. These were first demonstrated with anatomical techniques, which indicate some of the exquisite spatial precision present in the circuitry...
  61. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons...
  62. ncbi Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36
    M R Deans
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 31:477-85. 2001
    ..However, the synchrony of these rhythms was weaker and more spatially restricted in the knockout. We conclude that electrical synapses containing Cx36 are critical for the generation of widespread, synchronous inhibitory activity...
  63. doi Multiplicative dynamics underlie the emergence of the log-normal distribution of spine sizes in the neocortex in vivo
    Yonatan Loewenstein
    Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Interdisciplinary Center for Neural Computation and Center for Study of Rationality, Hebrew University, Jerusalem 91904, Israel
    J Neurosci 31:9481-8. 2011
    What fundamental properties of synaptic connectivity in the neocortex stem from the ongoing dynamics of synaptic changes? In this study, we seek to find the rules shaping the stationary distribution of synaptic efficacies in the cortex...
  64. ncbi Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex
    John J Dougherty
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 23:6740-7. 2003
    ..in presynaptic Ca2+ level via confocal imaging of isolated presynaptic nerve endings from rat hippocampus and neocortex. Abeta1-42 appeared to inhibit presynaptic nAChR activation by nicotine...
  65. ncbi Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    The thalamus provides fundamental input to the neocortex. This input activates inhibitory interneurons more strongly than excitatory neurons, triggering powerful feedforward inhibition...
  66. pmc Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex
    Santos J Franco
    Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 69:482-97. 2011
    ....
  67. ncbi RNAi reveals doublecortin is required for radial migration in rat neocortex
    Jilin Bai
    Department of Physiology and Neurobiology, University of Connecticut, 3107 Horsebarn Hill Road, U 4156, Storrs, Connecticut 06269, USA
    Nat Neurosci 6:1277-83. 2003
    Mutations in the doublecortin gene (DCX) in humans cause malformation of the cerebral neocortex. Paradoxically, genetic deletion of Dcx in mice does not cause neocortical malformation...
  68. pmc New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors
    Alexandre G Dayer
    Unit on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Cell Biol 168:415-27. 2005
    ..In the neocortex and striatum, we found BrdU-labeled cells that expressed each of the eight neuronal markers...
  69. ncbi Spine growth precedes synapse formation in the adult neocortex in vivo
    Graham W Knott
    Départment de Biologie Cellulaire et de Morphologie, University of Lausanne, Lausanne CH1005, Switzerland
    Nat Neurosci 9:1117-24. 2006
    ..In some instances, two new spines contacted the same axon. Our data show that spine growth precedes synapse formation and that new synapses form preferentially onto existing boutons...
  70. ncbi Fate mapping Nkx2.1-lineage cells in the mouse telencephalon
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 506:16-29. 2008
    ..1-expressing regions. In this paper, we present fate-mapping data on Nkx2.1-lineage neurons throughout the telencephalon, including the cerebral cortex, amygdala, olfactory bulb, striatum, globus pallidus, septum, and nucleus basalis...
  71. ncbi Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanisms
    David J Pinto
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 25:8131-40. 2005
    Waves of epileptiform activity in neocortex have three phenomenological stages: initiation, propagation, and termination...
  72. ncbi Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex
    Y Zilberter
    Abteilung Zellphysiologie, Max Plank Institut für Medizinische Forschung, Heidelberg, Federal Republic of Germany
    Neuron 24:979-88. 1999
    GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer...
  73. ncbi Model of autism: increased ratio of excitation/inhibition in key neural systems
    J L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, USA
    Genes Brain Behav 2:255-67. 2003
    ..Furthermore, the model suggests potential therapeutic interventions...
  74. ncbi Fezl is required for the birth and specification of corticospinal motor neurons
    Bradley J Molyneaux
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neuron 47:817-31. 2005
    ..of corticospinal motor neurons and other subcerebral projection neurons, which are absent from Fezl null mutant neocortex. There is neither an increase in cell death in Fezl(-/-) cortex nor abnormalities in migration, indicating that ..
  75. ncbi Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo
    Zita Gajda
    Department of Comparative Physiology, University of Szeged, Szeged, Hungary
    Epilepsia 46:1581-91. 2005
    ....
  76. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
    ..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions...
  77. pmc Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice
    Didrik S Frydenlund
    Nordic Centre of Excellence for Research in Water Imbalance Related Disorders WIRED, Centre for Molecular Biology and Neuroscience, Department of Anatomy, University of Oslo, P O Box 1105, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 103:13532-6. 2006
    ..Here we demonstrate by quantitative immunogold cytochemistry that the ischemic striatum and neocortex show distinct patterns of AQP4 expression in the reperfusion phase after 90 min of middle cerebral artery ..
  78. pmc Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex
    Yves Jossin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Neurosci 14:697-703. 2011
    ..However, inhibition of Rap1 or NCad had little effect on glia-dependent locomotion. We propose a multistep mechanism in which Reelin activates Rap1, Rap1 upregulates NCad, and NCad is needed to orient cell migration...
  79. pmc Selective optogenetic stimulation of cholinergic axons in neocortex
    Abigail Kalmbach
    Department of Physiology, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
    J Neurophysiol 107:2008-19. 2012
    ..The majority of cholinergic afferents to neocortex are from neurons in nucleus basalis...
  80. pmc Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures
    Hongkui Zeng
    Allen Institute for Brain Science, Seattle, WA 98103, USA
    Cell 149:483-96. 2012
    ....
  81. pmc Crossmodal propagation of sensory-evoked and spontaneous activity in the rat neocortex
    Kentaroh Takagaki
    Department of Physiology and Biophysics, Georgetown University, Washington, DC 20057, United States
    Neurosci Lett 431:191-6. 2008
    ..Taken together, these findings demonstrate that intracortical networks show pre-attentive crossmodal propagation of activity, and suggest a potential mechanism for the establishment of crossmodal integration...
  82. doi A mechanism for inside-out lamination in the neocortex
    Jonathan A Cooper
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Trends Neurosci 31:113-9. 2008
    We outline a unified model for inside-out layering of the neocortex, hinging on a new interpretation for the effects of Reelin on neuronal migrations...
  83. pmc Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Comp Neurol 510:79-99. 2008
    ....
  84. pmc Spiral wave dynamics in neocortex
    Xiaoying Huang
    Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA
    Neuron 68:978-90. 2010
    ..Using voltage-sensitive dye imaging, we found that spiral waves occur frequently in the neocortex in vivo, both during pharmacologically induced oscillations and during sleep-like states...
  85. pmc Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Proc Natl Acad Sci U S A 100:10523-8. 2003
    ....
  86. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    The developing neocortex contains two types of progenitor cells for glutamatergic, pyramidal-projection neurons...
  87. ncbi Role of Sox2 in the development of the mouse neocortex
    Mahmud Bani-Yaghoub
    Neurogenesis and Brain Repair Group, Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Rd, Bldg M 54, Ottawa, ON, Canada K1A 0R6
    Dev Biol 295:52-66. 2006
    The mammalian neocortex is established from neural stem and progenitor cells that utilize specific transcriptional and environmental factors to create functional neurons and astrocytes...
  88. pmc Developing neocortex organization and connectivity in cats revealed by direct correlation of diffusion tractography and histology
    Emi Takahashi
    Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 21:200-11. 2011
    ..These results suggest that diffusion tractography can differentially characterize internal and external SP zones and their transition into mature cortical pathways...
  89. doi Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury
    Lie Yang
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurotrauma 27:1541-8. 2010
    ....
  90. doi Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity
    Catherine A Blizzard
    Wicking Dementia Research and Education Centre, Menzies Research Institute, Hobart Tasmania 7000, Australia
    Cereb Cortex 21:281-91. 2011
    ..Focal acute injury was induced by transient insertion of a needle into the neocortex of anesthetized adult male Hooded-Wistar rats and thy1 green fluorescent protein (GFP) mice...
  91. doi Hippocampus and neocortex: recognition and spatial memory
    Seralynne D Vann
    School of Psychology, Cardiff University, Cardiff, UK
    Curr Opin Neurobiol 21:440-5. 2011
    ..Future models of spatial and recognition memory will have to extend beyond the hippocampus and perirhinal cortex to incorporate a wider network of cortical and subcortical structures...
  92. pmc Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits
    Katherine A Buchanan
    Department of Neuroscience, Physiology, and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Neuron 75:451-66. 2012
    ..We conclude that postsynaptic cell type determines presynaptic terminal molecular identity and that preNMDARs govern information processing in neocortical columns...
  93. ncbi The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
    N Dahmane
    Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:5201-12. 2001
    ..We show that Sonic hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex and tectum, whereas the Gli genes, which are targets and mediators of SHH signaling, are expressed in ..
  94. pmc GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
    Doris D Wang
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:5547-58. 2008
    ..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex...
  95. pmc MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 21:75-9. 2010
    ..02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses...
  96. pmc Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex
    Elizabeth K Stancik
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 30:7028-36. 2010
    ..separate from both RGCs and IPCs, and uncovering their unique proliferative and lineage properties, these results demonstrate how individual neural precursor groups in the embryonic rodent VZ create diversity in the overlying neocortex.
  97. pmc The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex
    Erika E Fanselow
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    J Neurophysiol 104:596-606. 2010
    The neocortex contains multiple types of inhibitory neurons whose properties suggest they may play different roles within the cortical circuit...
  98. pmc Correlated connectivity and the distribution of firing rates in the neocortex
    Alexei A Koulakov
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 29:3685-94. 2009
    ..Our results represent a first step toward reconciling sparse activity and sparse connectivity in cortical networks...
  99. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated striatal ..
  100. pmc Tuning of the human neocortex to the temporal dynamics of attended events
    Julien Besle
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 31:3176-85. 2011
    ..Thus, attentional entrainment appears to tune a network of brain areas to the temporal dynamics of behaviorally relevant event streams, contributing to its perceptual and behavioral selection...
  101. ncbi Neurogenesis in adult primate neocortex: an evaluation of the evidence
    Pasko Rakic
    Pasko Rakic is at the Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Neurosci 3:65-71. 2002
    Reports of continuous genesis and turnover of neurons in the adult primate association neocortex--the site of the highest cognitive functions--have generated great excitement...

Research Grants70

  1. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..ABCG1 transcription and expression in neurons and astrocytes and on cholesterol levels will be assessed in the neocortex of rat fetuses at gestational day 21...
  2. Pat Levitt; Fiscal Year: 2016
    ..Our preliminary data from the conditional deletion of Met in the neocortex provides direct evidence that Met signaling is involved in the structural and biochemical maturation of synapses...
  3. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..The thalamus serves as a gateway for the transfer of sensory information from peripheral sense organs to the neocortex. Our proposed experiments are designed to identify basic cellular properties underlying the gating properties of ..
  4. Arnold Kriegstein; Fiscal Year: 2014
    ..the differential behavior of self-renewing progenitors versus differentiating progeny in the embryonic mouse neocortex. Centrosome defects in Drosophila do not dramatically perturb mitosis in most somatic cells, but the asymmetric ..
  5. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..Gamma frequency oscillations (30-90 Hz) are found in many parts of the nervous system, including the hippocampus, neocortex, entorhinal cortex and amygdala...
  6. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..hippocampal LTP also restore stable potentiation (4A) and spine measures (4B) in slices from somatosensory neocortex of Fmr1-KO mice...
  7. KRISTIN GIAMANCO; Fiscal Year: 2015
    ..These D- type cyclins are expressed in different progenitor pools of the embryonic mouse neocortex and the medial ganglionic eminence (MGE), the origin of cortical parvalbumin (PV)- and somatostatin (SST)-..
  8. Robert A Sweet; Fiscal Year: 2016
    ..completion of the planned analyses will inform whether: 1) there is excess loss of dendritic spines in neocortex of AD+P subjects;2) the degree of spine loss is correlated with concentrations of soluble A(, or alternatively, ..
  9. Kimberly Huber; Fiscal Year: 2016
    Project Summary: Cortical structures (the hippocampus and neocortex) are critical for cognition and perception, and their improper function is implicated in intellectual disability and autism...
  10. XIANJIN ZHOU; Fiscal Year: 2014
    ..The expression of Sp4-NMDAR1 will be restored in excitatory and inhibitory neurons of both neocortex and hippocampus, to reverse prepulse inhibition gating deficits in Sp4 hypomorphic mice...
  11. John R Huguenard; Fiscal Year: 2016
    ..activity in cortex and thalamus;development, organization, and synaptic physiology of the CNS, especially neocortex and hippocampus;cellular and molecular aspects of long-term changes in neuronal excitability;and the roles of ..
  12. Hal Blumenfeld; Fiscal Year: 2016
    ..are associated with slow waves on electro- encephalography (EEG) and decreased cerebral blood flow (CBF) in the neocortex, distant from the hippocampus...
  13. Pasko Rakic; Fiscal Year: 2015
    ..and molecular mechanisms of neuronal proliferation, commitment and migration that determine the size of the neocortex as well as the laminar and areal positions of neurons in rodents and primates, including human...
  14. The Functional Maturation of Inhibitory Interneurons
    MATTHEW LAZARUS; Fiscal Year: 2010
    GABAergic inhibitory interneurons in neocortex are a diverse group of cells that provide precise spatial and temporal control over the activity of local neural circuits...
  15. Optimization of the FPI model for epilepsy therapy development
    RAIMONDO D'AMBROSIO; Fiscal Year: 2013
    ..The rat frontal neocortex is more sensitive to FPI than other brain areas, resulting in faster epileptogenesis than parietal/occipita ..
  16. Cell type-based genomics of developmental plasticity in cortical GABA interneuron
    Z Josh Huang; Fiscal Year: 2010
    GABA-mediated inhibition is crucial for the function and plasticity of neural circuits in neocortex, but the cellular diversity of the GABAergic system has been resistant to conventional anatomical, physiological, and genomic approaches...
  17. Neuronal Somatic Response to Traumatic Brain Injury
    John T Povlishock; Fiscal Year: 2010
    ..These phenomena were observed in diffusely injured neuronal somata throughout the neocortex, interspersed with other intact and unaltered neuronal cell bodies...
  18. William J Spain; Fiscal Year: 2016
    ..The focus is on the responses of principal cells in neocortex (pyramidal neurons) to local circuit activity...
  19. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2012
    ..We have identified a novel mechanism for the development of epilepsy following BBB compromise: in the rat neocortex, we have shown that opening of the BBB leads to the development of focal epileptiform activity, similar to that ..
  20. Glial Proliferation and Death in Depression and Alcoholism
    Jose Javier Miguel Hidalgo; Fiscal Year: 2010
    ..Since, unlike neurons, glial cells are continuously capable of proliferating in the normal neocortex, we hypothesize that there will be a lower proportion of proliferating astrocytes, oligodendrocytes, microglia ..
  21. White Matter Lesions and Cortical Serotonergic Deafferentation in Older Adults
    Martijn L T M Muller; Fiscal Year: 2010
    ..closely around the frontal horn of the ventricles and the anterior corpus callosum before fanning out to the neocortex. As WML of aging have an anatomic predilection for the periventricular white matter areas, including the ..
  22. GRETCHEN OLSON REYNOLDS; Fiscal Year: 2015
    ..a current view is that PD brain pathology begins in the lower brainstem before progressing to the midbrain and neocortex. If anxiety in PD develops prior to the motor symptoms, it may be a marker of underlying neuropathology in the ..
  23. Maternal smoking and hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2010
    ..major output of the hippocampus, receive two major excitatory synaptic inputs directly or indirectly from the neocortex. Nicotine modulates synaptic transmission and long-term potentiation (LTP;one form of synaptic plasticity and ..
  24. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul J Muchowski; Fiscal Year: 2012
    ..metabolites in the KP, quinolinic acid (QUIN) and 3-hydroxykynurenine (3-HK), are increased in the striatum and neocortex in early grade HD;similar increases in QUIN and/or 3-HK are present in three mouse models of HD...
  25. Subcortical control of neocortical slowing during focal hippocampal seizures
    JOSHUA ETHAN MOTELOW; Fiscal Year: 2012
    ..Hz ictal neocortical slow waves on electroencephalography (EEG) and decreased cerebral blood flow (CBF) in the neocortex. It is unknown how a focal seizure in the limbic system (including the hippocampus) creates ictal slowing in the ..
  26. Do Young Kim; Fiscal Year: 2014
    ..Similarly, we have shown that ketone bodies alone can reduce reactive oxygen species (ROS) formation in neocortex and prevent oxidative impairment of hippocampal long- term potentiation (LTP) in rats...
  27. Jeffrey D Macklis; Fiscal Year: 2016
    ..CTIP2 (COUP-TF interacting protein 2) and its paralog CTIP1 in development of CSMN and related neurons in murine neocortex. Ctip2 has increasingly emerged as both a critical regulator of development and connectivity of CSMN, and as a ..
  28. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..In fact, each day in neocortex, sleep- related twitches trigger thousands of cortical oscillatory events - called spindl bursts...
  29. Maternal nicotine exposure and development of hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2013
    ..output of the hippocampus, receive two major excitatory synaptic inputs either directly or indirectly from the neocortex. Nicotine modulates synaptic transmission and long-term potentiation (LTP;one form of synaptic plasticity ..
  30. Synaptic Circuitry in Stroke
    Sergei A Kirov; Fiscal Year: 2013
    ..aims are: 1) To test the hypothesis that SD-inflicted dendritic structural rearrangements in naive healthy neocortex depend on the degree of the transient tissue hypoxia imposed by SD...
  31. Song Hai Shi; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Proper formation of the neocortex depends on the orderly production of a large number of neurons during embryonic development...
  32. Time lapse imaging of serotonin axon regeneration in the neocortex of adult mouse
    David J Linden; Fiscal Year: 2013
    ..Using a two-photon microscope and a cranial window, we can repeatedly image the same volume of neocortex and thereby track serotonergic axons before and e 13 weeks after lesion with PCA to provide time-lapse ..
  33. Stem Cells for Brain Repair
    DANIEL ALAN PETERSON; Fiscal Year: 2013
    ..by applicant): The goal of this study is to recruit endogenous neural progenitor cells (NPCs) within the neocortex and direct their cell fate so that they can contribute to brain repair...
  34. Cell Type-Specific Synaptic Defects in Angelman Syndrome Model Mice
    Michael L Wallace; Fiscal Year: 2012
    ..EEG rhythms and seizures of neocortical origin, I propose that a well-defined inhibitory synaptic deficit in the neocortex occurs in the absence of Ube3a...
  35. Catherine A Thorn; Fiscal Year: 2014
    ..this hypothesis by assessing the specific impact of sensory processing in CM/Pf on its downstream targets in neocortex and basal ganglia using a combination of correlative, causal (optogenetic) and behavioral measures...
  36. Mayank R Mehta; Fiscal Year: 2014
    ..It is hypothesized that the neocortex sends information to the hippocampus during behavior and the hippocampus learns the associations between these ..
  37. Cell-based Genomic Analysis in Mouse Models of Rett Syndrome
    Z Josh Huang; Fiscal Year: 2010
    ..profiles in major classes of glutamatergic and GABAergic neurons in the motor and cognitive areas of the mouse neocortex at 3 stages of postnatal development...
  38. Nicholas P Poolos; Fiscal Year: 2016
    ..modulate excitability in several brain regions involved in the pathogenesis of epilepsy, including hippocampus, neocortex, and thalamus...
  39. Functional Activity Mapping of Brain Networks
    Carol A Barnes; Fiscal Year: 2010
    ..the implementation of these automated methods will allow us to examine both hippocampus and large areas of neocortex that would not have been possible within this timeframe with manual methods...
  40. Somatostatin Agonist Treatment for Cognitive Aging and Dementia
    Ken A Witt; Fiscal Year: 2010
    ..Additionally, the somatostatin receptor subtype-4 (SSTR4) is highly expressed in neocortex and hippocampus, areas significantly affected by Ab accumulation in AD patients...
  41. Imaging the Mitochondrial Response to Neural Activity
    Roger J Springett; Fiscal Year: 2010
    ..have the spatial and depth precision sufficient to resolve the columnar and laminar structure of the mammalian neocortex, and have the temporal precision to resolve events at the timescale of the neuronal circuits...
  42. JEROME NONE ENGEL; Fiscal Year: 2016
    ..or whether neocortical seizures also occur, and if so, whether hippocampal seizures reflect propagation from neocortex. Since the original submission of this proposal, we have recorded epileptiform discharges in neocortex anterior ..
  43. Tarik F Haydar; Fiscal Year: 2014
    ..Furthermore, RGCs are thought now to be the prenatal stem cell of the neocortex, and several groups have suggested that the neocortical ventricular zone (VZ) is composed solely of RGCs during ..
  44. Cell Adhesion Molecules in CNS Development
    Ulrich Mueller; Fiscal Year: 2013
    ..The long-term goal of my laboratory is to elucidate the mechanisms that control the development of the neocortex and defects in this process that cause disease...
  45. ANNA DENISE RESURRECCION GARCIA; Fiscal Year: 2015
    ..This study proposes to examine the role of astrocytes in mediating the dynamics of dendritic spines in the neocortex of adult mice...
  46. Mladen Roko Rasin; Fiscal Year: 2015
    ..this is the first evidence that an RBP binds a subset of six forkhead mRNAs in any system, including developing neocortex. Moreover, we identified a thalamic morphogen signal that affects the phosphorylation state of this neocortical ..
  47. Accelerated Software Tools for Neuroimaging Analysis
    Bruce Fischl; Fiscal Year: 2011
    ..human brain, including the automated construction of models of the hippocampus, amygdala, ventricular system and neocortex. These tools have been designed for use in a research setting, and have deepened our understanding of a wide ..
  48. Carlos Portera-Cailliau; Fiscal Year: 2014
    ..In mouse neocortex, we and others have shown that the 2nd postnatal week is a time when dendritic spines become stabilized, the ..
  49. Controlling Interareal Gamma Coherence by Optogenetics, Pharmacology and Behavior
    Timothy J Buschman; Fiscal Year: 2012
    ..Cholinergic agonists induce gamma oscillations in the neocortex and acetylcholine may underlie the inter-areal coherence observed in attention...
  50. Molecular Controls over Callosal Projection Neuron Subtype Specification and Dive
    RYAN MARIE FAME; Fiscal Year: 2012
    ..In particular, the molecular-genetic programs that regulate the complex neuronal heterogeneity of the mammalian neocortex are only beginning to be discerned...
  51. Randy M Bruno; Fiscal Year: 2016
    ..affect cortical activity and processing of sensory stimuli, with a focus on the initial stages of processing in neocortex. Processing is thought to begin with sensory information from the outside world entering sensory cortex via ..
  52. Development of a Microfluidic Thermal Regulator for Studies of Cortical Function
    LEAH ANN KRUBITZER; Fiscal Year: 2013
    ..to develop a miniaturized microfluidic thermal regulator to reversibly deactivate one or multiple areas of the neocortex through thermal regulation...
  53. Excitation and Inhibition Balance: Sensitive Period Plasticity
    QIANQUAN SUN; Fiscal Year: 2013
    ..Disturbances in the balance of excitation (E) and inhibition (I) in the neocortex provoke abnormal activities, such as epileptic seizures and abnormal cortical development...
  54. PERCEPTUAL BASES OF VISUAL CONCEPTS
    Edward A Wasserman; Fiscal Year: 2010
    ..the pigeon-a highly visual animal which can readily learn, but which does not have language or a mammalian neocortex and whose history can be carefully controlled and systematically varied-the processes of visual recognition and ..
  55. Forebrain Development in Down Syndrome and in Ts65Dn model mice
    Tarik F Haydar; Fiscal Year: 2010
    ..are thought to be due to altered brain development as changes in cell number and volume are found in neocortex, hippocampus and cerebellum in the perinatal and juvenile postmortem brain...
  56. GORDON J FISHELL; Fiscal Year: 2016
    ..specifically focus on the development of somatostatin-expressing cortical interneurons within this region of the neocortex. As shown in our preliminary studies, this population of cortical interneurons is the first to be born and ..
  57. Jack Waters; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The neocortex plays a central role in many higher-order functions such as the interpretation of sensory information, comprehension of language and control of voluntary movements...
  58. NMR Studies of Brain Energetics & Hypoglycemia In Vivo
    Kevin Behar; Fiscal Year: 2009
    ..between the rates of glucose utilization and neurotransmitter cycling of glutamate and GABA in the rat neocortex. The studies will be conducted in physiological normal rats and in a rat model of recurrent-hypoglycemia where ..
  59. Anthony P Barnes; Fiscal Year: 2016
    ..mechanism specifying the timing of cell differentiation and post-mitotic characteristics in the developing neocortex. We have previously undertaken studies to identify genes controlling polarity during cortical development and ..
  60. Epilepsy and dendritic excitability
    NICHOLAS POOLOS; Fiscal Year: 2009
    ..modulate excitability in several brain regions involved in the pathogenesis of epilepsy, including hippocampus, neocortex, and thalamus...
  61. Ctip2 Function in Corticospinal Motor Neuron Development
    MOLLIE BURGOON WOODWORTH; Fiscal Year: 2012
    ..differentiation of both corticospinal motor neurons (CSMN) (and related subcerebral projection neurons) in the neocortex and medium-sized spiny neurons (MSN) in the striatum;however, the specific molecular differentiation programs ..
  62. Timothy J Buschman; Fiscal Year: 2015
    ..Cholinergic agonists induce gamma oscillations in the neocortex and acetylcholine may underlie the inter-areal coherence observed in attention...
  63. Serotonin Glutamate Interactions in Prefrontal Cortex
    Gerard Marek; Fiscal Year: 2001
    ..are known to be strongly expressed in the apical dendritic region of layer V pyramidal cells throughout the neocortex. This localization may underly the most prominent effect of 5-HT2A receptor activation throughout the cortex: ..
  64. A comparative study of visual cortex in diurnal and nocturnal rodents.
    KATHARINE CAMPI; Fiscal Year: 2009
    ..Despite the fact that rodents are the most widely used model to study the brain, including the neocortex, there are still large issues regarding cortical organization that remain unresolved...
  65. Computational analysis of genesis of ERP and ERF
    Shingo Murakami; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): We propose to develop mathematical network models of the mammalian neocortex in order to elucidate the genesis of event-related magnetic fields (ERFs) and electrical potentials (ERPs)...
  66. Role of inhibition in shaping neocortical activity: normal vs fmr1 knockout mouse
    Detlef Heck; Fiscal Year: 2009
    ..and of a mouse model of the disease (Fmr1 knock-out) showed a significantly altered morphology of neurons in the neocortex, cerebellum, as well as other parts of the brain...
  67. Imaging neural networks in mouse somatosensory cortex
    JOSHUA BRUMBERG; Fiscal Year: 2003
    The neocortex constitutes the largest component of the brain in mammals and is the primary site of mental functions. Crucial to its functionality are the interactions between distinct neuronal networks within the cortex...
  68. CA CHANNELS IN THALAMIC & HIPPOCAMPAL RHYTHMIC ACTIVITY
    Matthew Anderson; Fiscal Year: 2004
    ..applicant's abstract): During the transition from the awake to the sleep state, neuronal activity in the neocortex is dramatically altered, previously chaotic activity becomes rhythmic and globally synchronous...