synaptic membranes

Summary

Summary: Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.

Top Publications

  1. pmc Ontogeny of postsynaptic density proteins at glutamatergic synapses
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Mol Cell Neurosci 29:436-52. 2005
  2. ncbi The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
    T M DeChiara
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 85:501-12. 1996
  3. ncbi Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
  4. ncbi Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation
    Tyler C Brown
    Neuroscience Program and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:13311-5. 2007
  5. ncbi Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    Sreeganga Chandra
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 123:383-96. 2005
  6. ncbi Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
    L Chen
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 408:936-43. 2000
  7. ncbi Inhibition of phosphatase activity prolongs NMDA-induced modification of the postsynaptic density
    A Dosemeci
    Marine Biological Laboratory, Woods Hole, MA 02543, USA
    J Neurocytol 31:605-12. 2002
  8. ncbi A novel particulate form of Ca(2+)/calmodulin-dependent [correction of Ca(2+)/CaMKII-dependent] protein kinase II in neurons
    A Dosemeci
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 20:3076-84. 2000
  9. pmc Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone
    Guido A Zampighi
    Department of Neurobiology, Jules Stein Eye Research Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 28:4151-60. 2008
  10. ncbi Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities
    U Wyneken
    Universidad de Los Andes, San Carlos de Apoquindo 2200, Santiago, Chile
    Neuroscience 102:65-74. 2001

Detail Information

Publications205 found, 100 shown here

  1. pmc Ontogeny of postsynaptic density proteins at glutamatergic synapses
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Mol Cell Neurosci 29:436-52. 2005
    ..Development was marked by substantial decreases in NR2B and SAP102 and increases in NR2A, PSD-95, AMPA receptors, and CaMKII. Other components showed more moderate changes...
  2. ncbi The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
    T M DeChiara
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 85:501-12. 1996
    ....
  3. ncbi Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
    ..We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles...
  4. ncbi Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation
    Tyler C Brown
    Neuroscience Program and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:13311-5. 2007
    ....
  5. ncbi Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    Sreeganga Chandra
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 123:383-96. 2005
    ....
  6. ncbi Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
    L Chen
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 408:936-43. 2000
    ....
  7. ncbi Inhibition of phosphatase activity prolongs NMDA-induced modification of the postsynaptic density
    A Dosemeci
    Marine Biological Laboratory, Woods Hole, MA 02543, USA
    J Neurocytol 31:605-12. 2002
    ..These results imply that NMDA receptors can mediate activity-induced changes in the PSD and that phosphatases of type 1 and/or 2A are involved in the reversal of these changes...
  8. ncbi A novel particulate form of Ca(2+)/calmodulin-dependent [correction of Ca(2+)/CaMKII-dependent] protein kinase II in neurons
    A Dosemeci
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 20:3076-84. 2000
    ..We propose that the observed clustering of CaMKII into spherical structures is a protective mechanism preventing excessive protein phosphorylation upon loss of Ca(2+) homeostasis, without compromising calmodulin regulation...
  9. pmc Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone
    Guido A Zampighi
    Department of Neurobiology, Jules Stein Eye Research Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 28:4151-60. 2008
    ....
  10. ncbi Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities
    U Wyneken
    Universidad de Los Andes, San Carlos de Apoquindo 2200, Santiago, Chile
    Neuroscience 102:65-74. 2001
    ..This rearrangement may accompany impairment of synaptic plasticity...
  11. pmc Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin
    Nadine Schmidt
    Institute of Physiology, Department of Biomedicine, University of Basel, CH 4056, Basel, Switzerland
    J Cell Biol 195:1171-84. 2011
    ..Our data indicate that NRG/ErbB signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of α-dystrobrevin1...
  12. ncbi The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
    M Geppert
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Nature 387:810-4. 1997
    ....
  13. ncbi Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an 'adult' acetylcholine receptor subunit
    A C Missias
    Department of Molecular Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 124:5075-86. 1997
    ..This decreased density led to a profound reorganization of AChR-associated components of the postsynaptic membrane and cytoskeleton. Together, these results suggest novel roles for AChRs in assembly of the postsynaptic apparatus...
  14. ncbi AMPA receptor tetramerization is mediated by Q/R editing
    Ingo H Greger
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Neuron 40:763-74. 2003
    ..Therefore, a single amino acid residue affects channel composition and, in turn, controls ion conduction through the majority of AMPARs in the brain...
  15. pmc A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis
    Emily Osterweil
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    J Cell Biol 168:329-38. 2005
    ..These results suggest that Myo6 plays a role in the clathrin-mediated endocytosis of AMPARs, and that its loss leads to alterations in synaptic structure and astrogliosis...
  16. ncbi Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses
    Isabel Pérez-Otaño
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, N C 27710, USA
    Neurosignals 13:175-89. 2004
    ..Here, we review recent evidence that challenges this view, focusing on the role that activity plays in altering NMDAR trafficking and how such dynamic regulation of NMDARs may impact on the plasticity of neural circuits...
  17. ncbi Snares and Munc18 in synaptic vesicle fusion
    Josep Rizo
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Rev Neurosci 3:641-53. 2002
  18. ncbi Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study
    Chikai Sakurada
    Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
    Biochem Pharmacol 64:1293-303. 2002
    ..Nociceptin was degraded by spinal synaptic membranes. Major metabolites of nociceptin were free phenylalanine, nociceptin (1-13) and nociceptin (14-17)...
  19. ncbi Surface trafficking of N-methyl-D-aspartate receptors: physiological and pathological perspectives
    L Groc
    Physiologie Cellulaire de la Synapse, UMR 5091 Centre National de la Recherche Scientifique, Universite Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, Cedex, France
    Neuroscience 158:4-18. 2009
    ....
  20. ncbi Calcium-independent phospholipase A(2) influences AMPA-mediated toxicity of hippocampal slices by regulating the GluR1 subunit in synaptic membranes
    Caroline Menard
    Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    Hippocampus 17:1109-20. 2007
    ..Given the importance of GluR1 subunit phosphorylation in the control of AMPA receptor delivery to synaptic membranes, we tested the influence of iPLA(2) activity on AMPA receptor distribution between neuronal compartments, ..
  21. ncbi Turnover of synaptic membranes: age-related changes and modulation by dietary restriction
    Susumu Ando
    Neuronal Function Research Group, Division of Neuroscience, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    J Neurosci Res 70:290-7. 2002
    ..constituents were labeled in vivo with deuterium and the disappearance of the deuterated molecules from synaptic membranes was measured by mass spectrometry...
  22. ncbi Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes
    F Checler
    J Biol Chem 261:11274-81. 1986
    ..formation of neurotensin-(1-10) and neurotensin-(11-13), was purified nearly to homogeneity from rat brain synaptic membranes. The enzyme appeared to be monomeric with a molecular weight of about 70,000-75,000 as determined by sodium ..
  23. pmc Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion...
  24. ncbi Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats
    César A J Ribeiro
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil
    Cell Mol Neurobiol 27:529-40. 2007
    ....
  25. ncbi The kinetics of synaptic vesicle pool depletion at CNS synaptic terminals
    Tomas Fernandez-Alfonso
    Department of Biochemistry, The Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuron 41:943-53. 2004
    ....
  26. ncbi Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapse
    David Lenzi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Neuron 36:649-59. 2002
    ..We conclude that formation of new synaptic vesicles from cisterns is rate limiting in the vesicle cycle...
  27. ncbi AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs
    V Haucke
    Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Science 285:1268-71. 1999
    ..This suggests a mechanism by which nucleation of clathrin-coated pits is stimulated by the loading of cargo proteins...
  28. ncbi Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes
    JOSE G ORTIZ
    Department of Pharmacology and Toxicology, University of Puerto Rico School of Medicine, PO Box 365067, San Juan, Puerto Rico
    Phytother Res 20:794-8. 2006
    ..These results suggest that particular care should be taken in analysing and interpreting results from commercial Valerian preparations...
  29. ncbi Dissociation of RalA from synaptic membranes by Ca2+/calmodulin
    J B Park
    Department of Biochemistry, College of Medicine, Hallym University, Chunchon, Kang Won Do, 200 702
    Biochem Biophys Res Commun 263:765-9. 1999
    ..Therefore, we examined if Ca2+/CaM can also cause the RalA to dissociate from SV membranes. In this study, we identified that Ca2+/CaM dissociates RalA as well as Rab3A from synaptic vesicles...
  30. ncbi Increased capacity and density of choline transporters situated in synaptic membranes of the right medial prefrontal cortex of attentional task-performing rats
    Subbu Apparsundaram
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 25:3851-6. 2005
    ....
  31. ncbi Effects of chronic ethanol treatment on the expression of calcium transport carriers and NMDA/glutamate receptor proteins in brain synaptic membranes
    X Chen
    Department of Pharmacology and Toxicology and the Center for Neurobiology and Immunology Research, University of Kansas, Lawrence 66045 2505, U S A
    J Neurochem 69:1559-69. 1997
    ..The enhanced expression of receptor and exchanger-associated proteins may explain the increases in the density and activity of NMDA receptors and exchange carriers after chronic ethanol treatment...
  32. ncbi Neuroscience. Synaptic membranes bend to the will of a neurotoxin
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    Science 310:1626-7. 2005
  33. ncbi Molecular mechanisms of presynaptic differentiation
    Yishi Jin
    Division of Biological Sciences, Section of Neurobiology, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Cell Dev Biol 24:237-62. 2008
    ..This review highlights the recent findings pertaining to the cellular and molecular regulation of presynaptic differentiation...
  34. ncbi Three-dimensional architecture of presynaptic terminal cytomatrix
    Lea Siksou
    INSERM U789, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 27:6868-77. 2007
    ..This 3D analysis reveals the morphological constraints exerted by the presynaptic molecular scaffold. SVs are tightly interconnected in the axonal bouton, and this network is preferentially connected to the AZ...
  35. ncbi Interaction between metals and chelating agents affects glutamate binding on brain synaptic membranes
    Felix Antunes Soares
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, RS, Brazil
    Neurochem Res 28:1859-65. 2003
    ..In addition, BAL was less effective to protect [3H]-glutamate binding inhibition caused by these metals than other chelating agents studied...
  36. ncbi Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
    ..Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner...
  37. pmc Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions
    R Mark Grady
    Dept of Pediatrics, Washington University School of Medicine, Pediatric Research Bldg, St Louis, MO 63110, USA
    J Cell Biol 160:741-52. 2003
    ..More generally, alphaDB may play multiple roles in muscle by means of differential distribution of isoforms with distinct signaling or structural properties...
  38. ncbi The postsynaptic submembrane machinery at the neuromuscular junction: requirement for rapsyn and the utrophin/dystrophin-associated complex
    Glen B Banks
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195 7290, USA
    J Neurocytol 32:709-26. 2003
    ..In addition we briefly review how these studies of the neuromuscular junction relate to GABAergic and glycinergic synapses in the CNS...
  39. ncbi Control of the postsynaptic membrane viscosity
    Marianne Renner
    Institut National de la Sante et de la Recherche Medicale, Biologie Cellulaire de la Synapse, 75005 Paris, France
    J Neurosci 29:2926-37. 2009
    ..Therefore, lipid composition and actin-dependent protein compaction regulate viscosity of the PSM and, consequently, the molecular flow in and out of synapses...
  40. pmc Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes
    Corina Russwurm
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum 44780, Germany
    J Biol Chem 284:25782-90. 2009
    ..In sum, these results demonstrate dual acylation as mechanism targeting neuronal PDE2A3 to synapses thereby ensuring local control of cyclic nucleotides...
  41. pmc A postsynaptic Mr 58,000 (58K) protein concentrated at acetylcholine receptor-rich sites in Torpedo electroplaques and skeletal muscle
    S C Froehner
    J Cell Biol 104:1633-46. 1987
    ..Thus, the concentration of this evolutionarily conserved protein at postsynaptic sites may be regulated by innervation or by muscle activity...
  42. pmc ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma
    Michael Krauss
    Zentrum für Biochemie und Molekulare Zellbiologie, Dept of Biochemistry II, University of Gottingen, Humboldtallee 23, Göttingen D 37073, Germany
    J Cell Biol 162:113-24. 2003
    ..These data suggest a model according to which activation of PIPKIgamma by ARF6-GTP facilitates clathrin-coated pit assembly at the synapse...
  43. pmc Clathrin dependence of synaptic-vesicle formation at the Drosophila neuromuscular junction
    HEATHER HEERSSEN
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Curr Biol 18:401-9. 2008
    ..Remarkably, it remains unknown whether clathrin is strictly necessary for the stimulus-dependent re-formation of a synaptic vesicle and, conversely, whether clathrin-independent vesicle endocytosis exists at the neuronal synapse...
  44. ncbi Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release
    Patrik Verstreken
    Program in Developmental Biology, Houston, TX, USA
    Cell 109:101-12. 2002
    ..We propose that kiss-and-run maintains neurotransmission at active zones of the larval NMJ in endophilin animals...
  45. ncbi Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice
    M Gautam
    Department of Molecular Biology, Washington University Medical School, St Louis, Missouri 63110, USA
    Nature 377:232-6. 1995
    ..We report that rapsyn is essential for the formation of AChR clusters, but that synapse-specific transcription of AChR subunit genes can proceed in its absence...
  46. ncbi Clathrin-mediated endocytosis at synapses
    Nadja Jung
    Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 6, 14195 Berlin, Germany
    Traffic 8:1129-36. 2007
    ....
  47. ncbi Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry
    Yoshiyuki Yoshimura
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima, Japan
    J Neurochem 88:759-68. 2004
    ..These results provide basic data on a major protein set associated with the PSD and a basis for future functional studies of this important neural machinery...
  48. pmc Modeling synaptic dynamics driven by receptor lateral diffusion
    David Holcman
    Department of Mathematics, Weizmann Institute of Science, Rehovot, Israel
    Biophys J 91:2405-15. 2006
    ....
  49. ncbi Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane
    H M Sadoulet-Puccio
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 5:489-96. 1996
    ..In addition, antibodies against either the Torpedo 87 kDa protein or human dystrobrevin demonstrate that at least three of the splice forms are translated as proteins in human brain tissue extracts...
  50. ncbi The excitatory postsynaptic density is a size exclusion diffusion environment
    Marianne L Renner
    Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Universite Bordeaux, Institut Francois Magendie, 146 rue Leo Saignat, 33077 Bordeaux Cedex, France
    Neuropharmacology 56:30-6. 2009
    ..The structure of the synaptic membrane is thus probably organized as a size exclusion matrix and this controls the rate of exchange of molecules with the extrasynaptic membrane...
  51. ncbi Postsynaptic signaling and plasticity mechanisms
    Morgan Sheng
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 298:776-80. 2002
    ..The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge...
  52. ncbi Bulk membrane retrieval in the synaptic terminal of retinal bipolar cells
    Matthew Holt
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 23:1329-39. 2003
    ..Bulk retrieval did not play an essential role in maintaining the vesicle cycle during maintained stimulation, but we suggest that it may play a role in the structural plasticity of this synaptic terminal...
  53. ncbi Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins
    N Brose
    Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA
    J Biol Chem 270:25273-80. 1995
    ..The presence of C1- and C2-domains in these proteins and the phenotype of the C. elegans mutants raise the possibility that Munc13s may have an essential signaling role during neurotransmitter release...
  54. ncbi Threshold firing frequency-current relationships of neurons in rat somatosensory cortex: type 1 and type 2 dynamics
    T Tateno
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    J Neurophysiol 92:2283-94. 2004
    ....
  55. ncbi alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis
    Euijung Jo
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Eur J Biochem 271:3180-9. 2004
    ..These results suggest that alterations in alpha-synuclein-lipid interactions may contribute to physiological changes detected in early onset PD...
  56. ncbi Three-dimensional reconstruction of a calyx of Held and its postsynaptic principal neuron in the medial nucleus of the trapezoid body
    Kurt Sätzler
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 22:10567-79. 2002
    ..The geometry of the reconstructed synapse suggests that each of the hundreds of SCs is likely to contribute independently to the size and rising phase of the EPSC during a single AP...
  57. ncbi Arachidonic acid allows SNARE complex formation in the presence of Munc18
    Colin Rickman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Chem Biol 12:545-53. 2005
    ....
  58. ncbi Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains
    Shohei Matsumoto
    Department of Anesthesiology, Tokyo Medical University Hospital, Nishishinjuku 6 7 1, Shinjuku ku, Tokyo, 160 0023, Japan
    Neurochem Res 33:2302-9. 2008
    ..These results may explain in part the cellular and molecular mechanisms of neuroprotective effects of isoflurane...
  59. ncbi Proteomic comparison of two fractions derived from the transsynaptic scaffold
    Greg R Phillips
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurosci Res 81:762-75. 2005
    ....
  60. ncbi AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse
    Laurent Groc
    UMR 5091 CNRS Université de Bordeaux 2 Physiologie Cellulaire de la Synapse, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Cell Tissue Res 326:423-38. 2006
    ..We focus on new findings that shed light on the regulation of receptor cycling events and surface trafficking and the way that this might reshape our thinking about the specific regulation of receptor accumulation at synapses...
  61. ncbi Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms
    Toshihiko Kuriu
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurosci 26:7693-706. 2006
    ..These results collectively indicate a critical role of filamentous actin in determining the extent of dynamic reorganization in PSD molecular composition...
  62. ncbi Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin
    Kimberly R Schuske
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Neuron 40:749-62. 2003
    ..These data suggest that endophilin is an adaptor protein required to localize and stabilize synaptojanin at membranes during synaptic vesicle recycling...
  63. pmc Anomalous diffusion in Purkinje cell dendrites caused by spines
    Fidel Santamaria
    Department of Neurobiology, Duke University Medical Center, PO Box 3209, Durham, North Carolina 27710, USA
    Neuron 52:635-48. 2006
    ..We conclude that an important function of dendritic spines may be to trap chemical signals and thereby create slowed anomalous diffusion within dendrites...
  64. ncbi Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor
    P Osten
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Heidelberg, Germany
    Neuron 27:313-25. 2000
    ..We conclude that the association of GluR2 with ABP and/or GRIP but not PICK1 is essential for maintaining the synaptic surface accumulation of the receptor, possibly by limiting its endocytotic rate...
  65. ncbi Signal-processing machines at the postsynaptic density
    M B Kennedy
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:750-4. 2000
    ..By changing synaptic strength in response to neural activity, the postsynaptic density contributes to information processing and the formation of memories...
  66. ncbi Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:307-20. 2006
    ..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system...
  67. ncbi Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: implications for the pathophysiology of epilepsy
    Marc Steffens
    Sektion Klinische Neuropharmakologie, Neurozentrum, Breisacherstrasse 64, D 79106 Freiburg, Germany
    Neurochem Int 47:379-84. 2005
    ..However, the detection of a significantly reduced enzymatic activity in the epileptic amygdala supports the assumption that the enzyme defect is localized to the epileptic mesial temporal lobe of corresponding patients...
  68. ncbi GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neurons
    Naoki Yamamoto
    Department of Alzheimer s Disease Research National Institute for Longevity Sciences National Center for Geriatrics and Gerontology 36 3 Gengo, Morioka, Obu 474 8522, Japan
    Biochim Biophys Acta 1768:1128-37. 2007
    ..expression of GM1 ganglioside is strictly cell-type-specific, and that expression of GM1 ganglioside on synaptic membranes is unique in terms of its high potency to induce Abeta assembly through the generation of GAbeta, which is ..
  69. ncbi [Receptor-independent spread of measles virus is unique to neurons, and involves fusion of synaptic membranes]
    N R Makhortova
    Mol Biol (Mosk) 41:186-8. 2007
  70. ncbi RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function
    F Schmitz
    Howard Hughes Medical Institute, Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 28:857-72. 2000
    ..Our results define a unique component of synaptic ribbons and suggest that RIBEYE evolved in vertebrates under utilization of a preexisting protein to build a unique scaffold for a specialized synapse...
  71. ncbi Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction
    K O Lai
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Mol Cell Neurosci 17:1034-47. 2001
    ..Since actin cytoskeleton is critical to the formation and stability of NMJ, the present findings raise the intriguing possibility that Eph receptors may have a novel role in NMJ formation and/or maintenance...
  72. ncbi Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes
    Sabine Wislet-Gendebien
    Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 281:32148-55. 2006
    ..Importantly, our finding that alpha-synuclein dissociation is up-regulated by both familial PD mutations implicates cytosolic cofactors in disease pathogenesis and as molecular targets to influence alpha-synuclein aggregation...
  73. ncbi PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse
    M R Wenk
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuron 32:79-88. 2001
    ..These results implicate PIPKIgamma in the synthesis of a PI(4,5)P(2) pool that acts as a positive regulator of clathrin coat recruitment and actin function at the synapse...
  74. ncbi Implication of geranylgeranyltransferase I in synapse formation
    Zhen G Luo
    Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 40:703-17. 2003
    ..These results support the notion that prenylation is necessary for AChR clustering and the NMJ formation and/or maintenance, revealing an active role of GGT in Agrin/MuSK signaling...
  75. ncbi Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions
    M Gonzalez
    Department of Neuroscience University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 24:567-83. 1999
    ..These results demonstrate a novel role for neurotrophin signaling through TrkB receptors on muscle fibers in the ongoing maintenance of postsynaptic AChR regions...
  76. ncbi Remodeling of synaptic membranes after induction of long-term potentiation
    N Toni
    Neuropharmacology, University Medical Center, 1211 Geneva 4, Switzerland
    J Neurosci 21:6245-51. 2001
    ....
  77. ncbi The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit
    V A Letts
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 19:340-7. 1998
    ....
  78. ncbi Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism
    J Noel
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, United Kingdom
    Neuron 23:365-76. 1999
    ..These data suggest that the NSF-GluR2 interaction is required for the surface expression of GluR2-containing AMPA receptors and that disruption of the interaction leads to the functional elimination of AMPA receptors at synapses...
  79. ncbi Comparative hydrolysis of extracellular adenine nucleotides and adenosine in synaptic membranes from porcine brain cortex, hippocampus, cerebellum and medulla oblongata
    Filip Kukulski
    Department of Biochemistry, Institute of General and Molecular Biology, N Copernicus University of Torun, Torun, Poland
    Brain Res 1030:49-56. 2004
    ..indicate that NTPDase1, NTPDase2, ecto-5'-nucleotidase, and adenosine deaminase are present in cortex synaptic membranes from porcine brain...
  80. ncbi 5-Aminolevulinic acid inhibits [3H]muscimol binding to human and rat brain synaptic membranes
    T Emanuelli
    Departamento de Ciencia e Tecnologia de Alimentos, Centro de Ciências Rurais, Universidade Federal de Santa Maria, RS, Brasil
    Neurochem Res 26:101-5. 2001
    ....
  81. ncbi Regulation of the phosphorylation state of the AMPA receptor GluR1 subunit in the postsynaptic density
    L Vinade
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Mol Neurobiol 20:451-63. 2000
    ..Thus, it is possible that a large pool of PSD-associated GluR1 is regulated through modification of the phosphorylation state of the Ser-831 site only...
  82. pmc Temporally distinct demands for classic cadherins in synapse formation and maturation
    Ozlem Bozdagi
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Neurosci 27:509-21. 2004
    ..These data provide new evidence that cadherins are required to promote synapse stabilization and structural and functional maturation, but dispensable for the correct subcellular distribution of excitatory and inhibitory synapses...
  83. ncbi GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission
    Vidar Gundersen
    Anatomical Institute and the Centre for Molecular Biology and Neuroscience, University of Oslo, Blindern, Oslo, N 0317, Norway
    Mol Cell Neurosci 26:156-65. 2004
    ..Under pathological conditions, release of an excitatory transmitter at an inhibitory synapse could contribute to the development of, for example, epilepsy...
  84. ncbi Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus
    Mark R Witcher
    Synapses and Cognitive Neuroscience Center, Medical College of Georgia, Augusta, Georgia, USA
    Glia 55:13-23. 2007
    ....
  85. ncbi Redistribution of microtubules in dendrites of hippocampal CA1 neurons after tetanic stimulation during long-term potentiation
    Fuyuki Mitsuyama
    Department of Neurosurgery, Fujita Health University, Aichi, Japan
    Ital J Anat Embryol 113:17-27. 2008
    ..This newly produced microtubules between stimulated postsynaptic membranes and the cell body must be the most promising candidate of the track for the trafficking of AMPA receptors to the stimulated postsynaptic plasma membrane...
  86. ncbi Synapses with a segmented, completely partitioned postsynaptic density express more AMPA receptors than other axospinous synaptic junctions
    O Ganeshina
    Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuroscience 125:615-23. 2004
    ..These findings are consistent with the idea that SCP synapses have a relatively greater efficacy and may support maximal levels of synaptic enhancement characteristic of certain forms of synaptic plasticity such as the early LTP phase...
  87. ncbi Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
    William Ju
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 7:244-53. 2004
    ....
  88. ncbi Morphologically identified glycinergic synapses in the hippocampus
    Lydia Danglot
    Laboratoire de Biologie Cellulaire de la Synapse N and P, Institut National de la Santé et de la Recherche Médicale U497, Ecole Normale Superieure, 75005 Paris, France
    Mol Cell Neurosci 27:394-403. 2004
    ..Finally, GlyR clusters could be detected at synaptic sites with the GABAA receptor gamma2 subunit and gephyrin, suggesting that mixed GABA/glycine synapses might exist in the hippocampus...
  89. ncbi Creation of AMPA-silent synapses in the neonatal hippocampus
    Min Yi Xiao
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Box 432, 405 30 Goteborg, Sweden
    Nat Neurosci 7:236-43. 2004
    ..The AMPA silencing, possibly explained by a removal of postsynaptic AMPA receptors, could subsequently be reversed by paired presynaptic and postsynaptic activity...
  90. ncbi Internalization at glutamatergic synapses during development
    Ronald S Petralia
    Laboratory of Neuroscience, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 18:3207-17. 2003
    ..Also, caveolin might be prevalent at excitatory synapses, although it is not known whether it is involved in receptor internalization, receptor stabilization, or some other function...
  91. pmc Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices
    Sky Pittson
    Department of Anesthesia, Stanford University School of Medicine, SUMC S288, Stanford, CA 94305 5117, USA
    BMC Neurosci 5:52. 2004
    ..The present study compared and contrasted effects produced by five general anesthetics on synaptic circuitry in the CA1 region of hippocampal slices...
  92. ncbi Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses
    Chengbiao Lu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 97:1104-10. 2006
    ..These findings suggest that, by selectively reducing AMPA currents and calcium influx, caspase-1 functions as a negative regulator of LTP at hippocampal synapses...
  93. ncbi Synaptogenesis of the calyx of Held: rapid onset of function and one-to-one morphological innervation
    Brian K Hoffpauir
    Sensory Neuroscience Research Center, Department of Otolaryngology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9303, USA
    J Neurosci 26:5511-23. 2006
    ..These data indicate that calyces of Held follow a noncanonical program to establish targeted innervation that occurs over a rapid time course and precedes auditory experience...
  94. pmc Ultrastructure of primary afferent terminals and synapses in the rat nucleus of the solitary tract: comparison among the greater superficial petrosal, chorda tympani, and glossopharyngeal nerves
    Olivia L May
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109 1078, USA
    J Comp Neurol 502:1066-78. 2007
    ..These normative data form the basis for future studies of developmentally and environmentally induced plasticity in the rodent brainstem...
  95. ncbi Ischemia-induced modifications in hippocampal CA1 stratum radiatum excitatory synapses
    Tatiana Kovalenko
    Department of Cytology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Hippocampus 16:814-25. 2006
    ..Comparison of the in vivo and in vitro model systems used in the study demonstrated a general similarity of these early morphological changes, confirming the validity of the in vitro model for studying synaptic structural plasticity...
  96. pmc Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 99:549-60. 2006
    ..NMDA treatment did not evoke changes in GluR3 localisation. Our results demonstrate that presynaptic and postsynaptic subunits are regulated in opposite directions by AMPA and NMDA stimulation...
  97. ncbi Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin
    Kensuke Futai
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:186-95. 2007
    ..Presynaptic beta-neurexin serves as a likely presynaptic mediator of this effect. Our results indicate that trans-synaptic protein-protein interactions can link postsynaptic and presynaptic function...
  98. ncbi A simple depletion model of the readily releasable pool of synaptic vesicles cannot account for paired-pulse depression
    Jane M Sullivan
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA, USA
    J Neurophysiol 97:948-50. 2007
    ....
  99. ncbi State-dependent mechanisms of LTP expression revealed by optical quantal analysis
    Bonnie Ward
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    Neuron 52:649-61. 2006
    ..Once unmasked, however, further potentiation of formerly silent synapses leads to an increase in p(r). The state of the synapse thus determines how LTP is expressed...
  100. ncbi Constitutive sharing of recycling synaptic vesicles between presynaptic boutons
    Kevin J Darcy
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 9:315-21. 2006
    ..Our results demonstrate that synaptic vesicle recycling is not confined to individual presynaptic terminals as is widely believed; rather, a substantial proportion of recycling vesicles are shared constitutively between boutons...
  101. ncbi Involvement of hyperpolarization-activated cation channels in synaptic modulation
    Marlène Genlain
    Laboratory of Neurosciences, University of Mons Hainaut, Mons, Belgium
    Neuroreport 18:1231-5. 2007
    ..This suggests that the Ih channel could be a bifunctional protein...

Research Grants63

  1. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2013
    ..test the hypothesis that D1R docking to a NFM-containing scaffold influences endocytic recycling of D1R to synaptic membranes and thus sensitivity to DA agonists (aim 2)...
  2. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
    ..It is hypothesized that extinction training promotes AMPA receptor insertion in synaptic membranes of D2 receptor-containing NAc neurons, and preliminary data show this effect may reverse D2 receptor ..
  3. Intra- and Inter-Neuronal Viral Trafficking
    Glenn F Rall; Fiscal Year: 2012
    ..of measles virus to the synapse is studied, which will characterize the viral proteins that are present at synaptic membranes, and whether these proteins are required for trans-synaptic spread...
  4. ISOLATION AND CHARACTERIZATION OF SYNAPTOGENIC PROTEINS
    JUAN L BRUSES; Fiscal Year: 2011
    ..which are required for the recognition of a postsynaptic target, the stabilization of the contact between synaptic membranes, and the functional coupling between synaptic compartments...
  5. Molecular and Cellular Analysis of Brain Enriched PTP's
    Paul J Lombroso; Fiscal Year: 2013
    ..STEP) regulates glutamate receptor trafficking, and removes both NR1/NR2B and GluR1/GluR2 receptors from synaptic membranes after specific forms of synaptic stimulation...
  6. Genetics Analysis of Neuronal Hypoxic Stress Resistance
    CHRISTOPHER G RONGO; Fiscal Year: 2013
    ..Indeed, the movement of glutamate receptors into and out of synaptic membranes after post-trauma hypoxia in some cultured neuronal systems can modulate excitotoxicity...
  7. The Role of Afadin in Coordinating Cell Adhesion Molecules during Synaptogenesis
    GERARD MJ BEAUDOIN; Fiscal Year: 2010
    ..cadherins and their associated catenins in regulating synapse number and maturation of both pre- and post-synaptic membranes. Expression studies have found that cadherin isoforms are not expressed ubiquitously, but are localized to ..
  8. Biomarkers predicting the severity of obstruction-induced bladder dysfunction
    Robert M Levin; Fiscal Year: 2013
    ..membranes to be studied include: nuclei, cell wall, mitochondria, sarcoplasmic reticulum, nerve and synaptic membranes. 2) We will quantitate the degree of functional (contractile), structural (SM/C), and biochemical (ROS and ..
  9. Molecular Analysis of Presynaptic Choline Transporters
    Randy D Blakely; Fiscal Year: 2013
    ..Preliminary studies document both a change in the localization of CHT in synaptic membranes in response to depolarization in wildtype mice and a posttranslational mechanism to achieve normal levels of ..
  10. EXPLORATION OF NEUROBEACHIN (NBEA)'S ROLE IN MULTIPLE MYELOMA
    Michael H Tomasson; Fiscal Year: 2010
    ..protein kinase A anchoring protein (AKAP) that is localized to the trans-Golgi, transport vesicles and post-synaptic membranes of neurons where it plays a functional role in neuronal cell synaptic transmission...
  11. DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAIN
    Gregory Anderson; Fiscal Year: 1993
    ..The brain and retina, and in particular the synaptic membranes and rod outer segments, are especially rich in the n-3 family of polyunsaturated fatty s...
  12. VTA Ionotropic Glutamate Receptors in Cocaine Addiction
    David Self; Fiscal Year: 2009
    ..PKA- and PKC/CaMKII-mediated phosphorylation processes that facilitate AMPA and NMDA receptor insertion into synaptic membranes, and enhance receptor function...
  13. P/Q-Type Channels and Cerebellar Synaptic Transmission
    YAPING LIAO; Fiscal Year: 2007
    ..is likely related to altered synaptic physiology, since PQCC is a key player in the pre- and post-synaptic membranes important in synaptic transmission and plasticity...
  14. Carbamathione, A Novel Disulfiram Metabolite for Cocaine Dependence
    MORRIS FAIMAN; Fiscal Year: 2009
    ..In vivo, carbamathione has no effect on ALDH2, but inhibits glutamate binding in synaptic membranes of brain homogenate...
  15. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..docosahexaenoic acid (DHA), is derived exclusively from the diet, is specifically enriched in neuronal synaptic membranes, and inhibits PKC in vitro...
  16. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2009
    ..apoE4 synaptic deficits can be partly explained by alterations in cholesterol and fatty acid metabolism in synaptic membranes. Therefore, we wish to test the following hypotheses...
  17. ETHANOL ACTION ON BRAIN ACIDIC PHOSPHOLIPIDS
    Grace Sun; Fiscal Year: 1999
    ..evidence that chronic ethanol ingestion leads to an increase in levels of the acidic phospholipids in synaptic membranes. Acidic phospholipids (PS, PA, PI, and poly-PI) are known to exert specific effects on membrane proteins due ..
  18. SYNAPTIC AMINO ACID TRANSPORT: ALCOHOL AND ALCOHOLISM
    DENNIS RHOADS; Fiscal Year: 1992
    ..This will both promote understanding of the associated-diseases and identify critical functional components of synaptic membranes that are altered by ethanol use/abuse and to which treatment might be directed.
  19. PSD-95 PROTEIN FAMILY IN RECEPTOR CLUSTERING
    Kyung Ok Cho; Fiscal Year: 2000
    ..how the important synaptic components including recept s and channels become localized to specific sites of synaptic membranes. A specialized, cytoskeletal structure called postsynaptic density has been implicated in the mechanism of ..
  20. PROTEIN CARBOXYL METHYLATION AND NEURONAL FUNCTION
    DANA ASWAD; Fiscal Year: 1990
    ..We propose to determine if the methyl accepting substrates we have located in synaptic membranes and myelin are enriched in these atypical forms of aspartate, and, to determine if the levels of these ..
  21. SYNAPTIC MEMBRANES, GLYCOPROTEINS AND DEVELOPMENT
    Robert Hitzemann; Fiscal Year: 1980
    ..The technical skills commensurate with successfully completing this study are evidenced by our publications...
  22. ACETYLCHOLINE RECEPTOR-CHANNEL MOLECULES
    LINCOLN POTTER; Fiscal Year: 1980
    ..projects; (1) To further validate our technique for visualizing receptor-channel molecules in the post-synaptic membranes of Narcine electric tissue by lengthening them with specific ligands; to examine for the same molecules in ..
  23. PHOSPHOPROTEIN METABOLISM IN EXPERIMENTAL EPILEPSY
    Robert Berman; Fiscal Year: 1980
    ..Specifically, the following proposal is designed to examine changes in phosphoprotein metabolism in synaptic membranes isolated from rats that have undergone the "Kindling" procedure, an experimental model of epilepsy...
  24. Cholesterol and fatty acids in cocaine addiction relapse
    Laure Buydens Branchey; Fiscal Year: 2004
    ..Some PUFAs are main components of neuronal synaptic membranes and influence neuronal function...
  25. GLUTATHIONE RECEPTOR PROBES FOR CNS STUDIES
    MARGARET LANGMUIR; Fiscal Year: 1993
    ..Binding constants for receptor sites have been measured using radiolabeled GSH on synaptic membranes and on cultured astrocyte cells...
  26. MODEL SYNAPTIC VESICLES INTERACTION WITH LIPID BILAYER
    Alan Finkelstein; Fiscal Year: 1980
    ..When a calcium-binding protein obtained from synaptic membranes is present in the planar membrane, the fusion rate is stimulated by micromolar amounts specifically of Ca ..
  27. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
    ..abstract_text> ..
  28. A Method To Study Membrane Protein Structure
    Guido Zampighi; Fiscal Year: 2003
    ....
  29. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
    ..abstract_text> ..
  30. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2008
    ..abstract_text> ..
  31. TECNIA 12 BioTWIN Transmission Electron Microscope
    Guido Zampighi; Fiscal Year: 2003
    ..abstract_text> ..
  32. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  33. Recognition coding at CNS synapses
    Greg R Phillips; Fiscal Year: 2010
    ..Upon completion of these Aims we expect to have a better understanding of the role of cell-cell interactions in synaptogenesis. ..
  34. Mechanisms of adhesion and recognition at CNS synapses
    Greg Phillips; Fiscal Year: 2005
    ..How the different sets of molecules target to synaptic membranes and remain in direct apposition to each other is still not completely understood but trans-synaptic ..
  35. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  36. L1 function and sensitivity to ethanol
    DEANNA BENSON; Fiscal Year: 2009
    ....
  37. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  38. Molecular mechanisms of vestibular hair cell exocytosis
    FELIX SCHWEIZER; Fiscal Year: 2009
    ..A detailed understanding of the proteins and mechanisms of release at this initial sensory synapse aid in identifying novel therapeutic approaches targeting vestibular dysfunction. ..
  39. IL-6 Regulation of Hippocampal Synaptic Function
    Donna L Gruol; Fiscal Year: 2010
    ..The proposed studies focus on this issue as it relates to CNS disorders. ..
  40. CIRCUITRY CONTROLLING THE HIPPOCAMPAL THETA RHYTHM
    ROBERT VERTES; Fiscal Year: 2002
    ..This work may have important implications for conditions such as Alzheimer's that involve a loss of cholinergic neurons of the MS/DBv. ..
  41. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  42. TARGETING OF BRAIN PROTEIN PHOSPHATASE 1
    ROGER COLBRAN; Fiscal Year: 2002
    ..These Aims provide novel insights into the physiological regulation of PP1, a key modulator of synaptic function. ..
  43. IMAGING EPILEPTIFORM ACTIVITY IN PIRIFORM CORTEX
    Meyer Jackson; Fiscal Year: 2001
    ..These experiments will thus reveal basic mechanisms responsible for epileptiform activity and thus provide a better conceptual framework for investigating human epilepsy, and for developing pharmacological treatments. ..
  44. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  45. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2009
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  46. IONIC HOMEOSTASIS AND SEIZURE REGULATION
    John Swann; Fiscal Year: 2009
    ..This hypothesis will be directly tested by measuring changes in intracellular calcium in glial cells and neurons during stimulus trains in hippocampal slices while measuring extracellular calcium. ..
  47. NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDS
    DONNA GRUOL; Fiscal Year: 2005
    ..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
  48. Somatic Ca2+ Signaling in CNS Neurons
    DONNA GRUOL; Fiscal Year: 2007
    ..However, the general principles identified by the studies will also contribute significantly to our understanding of the role of activity-dependent gene expression during development in other CNS neuronal types. [unreadable] [unreadable]..
  49. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2004
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  50. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  52. Prenatal Cannabis Effect on the Endocannabinoid System
    VINOD YARAGUDRI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. Molecular Targets of A-beta-Induced Synaptic Dysfunction
    Michael Ehlers; Fiscal Year: 2008
    ..As such, the proposed research holds promise for the development of new therapeutic approaches for AD-associated memory loss and cognitive deficit. ..
  54. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
  55. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2009
    ..Our work may illuminate how synaptic dysregulation can lead eventually to neuronal apoptosis. ..
  56. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    Joachim Herz; Fiscal Year: 2009
    ..This may provide novel targets for rational drug design and treatment of atherosclerosis as well as of AD, both disorders of increasing medical and socio-economic importance. ..
  57. Mechanism of Stargazin-Regulated AMPAR Trafficking
    Lu Chen; Fiscal Year: 2009
    ..The proposed studies will advance our understanding on molecular mechanisms of synaptogenesis and plasticity, thereby providing insights in these brain diseases, and their remediation. ..
  58. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  59. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2009
    ....
  60. Mechanisms of Axon Outgrowth and Targeting
    Deanna L Benson; Fiscal Year: 2010
    ..Results from this work will inform the analysis and interpretation of an in vivo study of ERM function in the regulation of axon outgrowth and branching. ..