crystalline lens

Summary

Summary: A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.

Top Publications

  1. ncbi alpha B subunit of lens-specific protein alpha-crystallin is present in other ocular and non-ocular tissues
    S P Bhat
    Jules Stein Eye Institute, University of California, School of Medicine, Los Angeles 90024 1771
    Biochem Biophys Res Commun 158:319-25. 1989
  2. ncbi Crystallins in the eye: Function and pathology
    Usha P Andley
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, 63110, USA
    Prog Retin Eye Res 26:78-98. 2007
  3. pmc Congenital cataracts and their molecular genetics
    J Fielding Hejtmancik
    MOGS OGVFB NEI NIH, Building 10, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 19:134-49. 2008
  4. ncbi Early eye development in vertebrates
    R L Chow
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Annu Rev Cell Dev Biol 17:255-96. 2001
  5. pmc Refractive index measurement of the isolated crystalline lens using optical coherence tomography
    Stephen R Uhlhorn
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA
    Vision Res 48:2732-8. 2008
  6. pmc Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens
    Ales Cvekl
    The Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Dev Biol 48:829-44. 2004
  7. pmc The membrane proteome of the mouse lens fiber cell
    Steven Bassnett
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 15:2448-63. 2009
  8. pmc Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
    P A Wilmarth
    Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, 611 South West Campus Drive, Portland, Oregon 97239, USA
    J Proteome Res 5:2554-66. 2006
  9. ncbi Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats
    Mustafa Naziroglu
    Department of Physiology, Veterinary Faculty, Firat University, TR 23119, Elazig, Turkey
    Toxicology 195:221-30. 2004
  10. ncbi Multiple functions for Pax6 in mouse eye and nasal development
    J C Quinn
    Department of Obstetrics and Gynecology, University of Edinburgh, UK
    Genes Dev 10:435-46. 1996

Detail Information

Publications314 found, 100 shown here

  1. ncbi alpha B subunit of lens-specific protein alpha-crystallin is present in other ocular and non-ocular tissues
    S P Bhat
    Jules Stein Eye Institute, University of California, School of Medicine, Los Angeles 90024 1771
    Biochem Biophys Res Commun 158:319-25. 1989
    ..Based on these observations we conclude that while alpha A has a tissue-specific role, alpha B is a polypeptide of independent function not restricted to the ocular lens...
  2. ncbi Crystallins in the eye: Function and pathology
    Usha P Andley
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, 63110, USA
    Prog Retin Eye Res 26:78-98. 2007
    ..These studies may be directly relevant to understanding the general cellular functions of crystallins...
  3. pmc Congenital cataracts and their molecular genetics
    J Fielding Hejtmancik
    MOGS OGVFB NEI NIH, Building 10, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 19:134-49. 2008
    Cataract can be defined as any opacity of the crystalline lens. Congenital cataract is particularly serious because it has the potential for inhibiting visual development, resulting in permanent blindness...
  4. ncbi Early eye development in vertebrates
    R L Chow
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Annu Rev Cell Dev Biol 17:255-96. 2001
    ..Questions about early eye development first addressed using tissue manipulations remain topical as we try to understand the molecular basis of this process...
  5. pmc Refractive index measurement of the isolated crystalline lens using optical coherence tomography
    Stephen R Uhlhorn
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA
    Vision Res 48:2732-8. 2008
    ..coherence tomography system has been developed that was designed specifically for imaging the isolated crystalline lens. Cross-sectional OCT images were recorded on 40 lenses from 32 human donors with an age range of 6-82 years...
  6. pmc Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens
    Ales Cvekl
    The Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Dev Biol 48:829-44. 2004
    ..We present novel data showing that pRb antagonizes Pax6-mediated activation of the alphaA-crystallin promoter likely by inhibiting binding of Pax6 to DNA...
  7. pmc The membrane proteome of the mouse lens fiber cell
    Steven Bassnett
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 15:2448-63. 2009
    ..In the current study, we utilized mass spectrometry-based shotgun proteomics to provide a comprehensive survey of the mouse lens fiber cell membrane proteome...
  8. pmc Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
    P A Wilmarth
    Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, 611 South West Campus Drive, Portland, Oregon 97239, USA
    J Proteome Res 5:2554-66. 2006
    ..On the basis of spectral counting, the most abundant PTMs in aged lenses were deamidations and methylated cysteines with other PTMs present at lower levels...
  9. ncbi Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats
    Mustafa Naziroglu
    Department of Physiology, Veterinary Faculty, Firat University, TR 23119, Elazig, Turkey
    Toxicology 195:221-30. 2004
    ..The selenium with high dose vitamin E injection may play a role in preventing cisplatin-induced nephropathy and cataract formation in cancer patient...
  10. ncbi Multiple functions for Pax6 in mouse eye and nasal development
    J C Quinn
    Department of Obstetrics and Gynecology, University of Edinburgh, UK
    Genes Dev 10:435-46. 1996
    ..We suggest that Pax6 may promote cell surface changes in the optic cup and control the fate of the ectoderm from which the lens and nasal epithelia are derived...
  11. ncbi Pentacam Scheimpflug quantitative imaging of the crystalline lens and intraocular lens
    Patricia Rosales
    Institute de Optica Daza de Valdés, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Refract Surg 25:421-8. 2009
    ..To implement geometrical and optical distortion correction methods for anterior segment Scheimpflug images obtained with a commercially available system (Pentacam, Oculus Optikgeräte GmbH)...
  12. ncbi Pax6 induces ectopic eyes in a vertebrate
    R L Chow
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 126:4213-22. 1999
    ..These data show that in vertebrates, as in the invertebrate Drosophila melanogaster, Pax6 is both necessary and sufficient to trigger the cascade of events required for eye formation...
  13. pmc Molecular genetics of age-related cataract
    J Fielding Hejtmancik
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD 20892, USA
    Exp Eye Res 79:3-9. 2004
    ..Together, these studies are beginning to provide a conceptual framework for understanding age-related cataracts...
  14. ncbi Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens
    Marc D Jacobs
    Department of Physiology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Invest Ophthalmol Vis Sci 45:191-9. 2004
    ..To map changes in the structure and function of fiber cell gap junctions that occur with lens differentiation...
  15. ncbi Pathways regulating lens induction in the mouse
    Richard A Lang
    Division of Developmental Biology and Department of Ophthalmology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Int J Dev Biol 48:783-91. 2004
    ..Given the complexity of this and many other developmental processes, a second century of analysis will be welcome...
  16. ncbi Anterior segment development relevant to glaucoma
    Douglas B Gould
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Int J Dev Biol 48:1015-29. 2004
    ....
  17. ncbi Bmp signaling is required for development of primary lens fiber cells
    Sonya C Faber
    Division of Developmental Biology and Department of Ophthalmology, Children s Hospital Research Foundation, 3333 Burnet Avenue Cincinnati, OH 45229, USA
    Development 129:3727-37. 2002
    ..We conclude that Bmp signaling is required for primary lens fiber cell differentiation and, given the asymmetry of the differentiation inhibition, that distinct differentiation stimuli may be active in different quadrants of the eye...
  18. ncbi The etiology of steroid cataract
    Eric R James
    Sanaria, Inc, Rockville, MD 20850, USA
    J Ocul Pharmacol Ther 23:403-20. 2007
    ....
  19. ncbi Advanced optics in a jellyfish eye
    Dan E Nilsson
    Department of Cell and Organism Biology, Lund University, Zoology Building, Helgonavagen 3, 22362 Lund, Sweden
    Nature 435:201-5. 2005
    ..We argue that this may be useful in eyes serving a single visual task. The findings indicate that tailoring of complex receptive fields might have been one of the original driving forces in the evolution of animal lenses...
  20. pmc Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    Haotian Zhao
    Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 318:276-88. 2008
    ..Therefore, while signaling by FGF receptors is essential for lens fiber differentiation, different FGF receptors function redundantly...
  21. ncbi Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells
    Jongkyu Choi
    Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Invest Ophthalmol Vis Sci 48:2708-18. 2007
    ..This study was conducted to determine whether the Snail gene family is activated in the process of TGFbeta1-induced EMT and how TGFbeta1 regulates the expression of this gene family...
  22. pmc BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration
    Matthew W Grogg
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Nature 438:858-62. 2005
    ....
  23. ncbi In vitro dimensions and curvatures of human lenses
    Alexandre M Rosen
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA
    Vision Res 46:1002-9. 2006
    ..Together, these observations provide additional support for the Helmholtz theory of accommodation...
  24. ncbi Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications
    Megha Saraswat
    National Institute of Nutrition, Hyderabad, India
    Asia Pac J Clin Nutr 17:558-65. 2008
    ..The findings reported here indicate the scope of adapting life-style modifications in the form of inclusion of certain common sources in the diet for the management of diabetic complications...
  25. ncbi Axial growth and changes in lenticular and corneal power during emmetropization in infants
    Donald O Mutti
    Ohio State University College of Optometry, 338 West Tenth Avenue, Columbus, OH 43210 1240, USA
    Invest Ophthalmol Vis Sci 46:3074-80. 2005
    ..To evaluate the contribution made by the ocular components to the emmetropization of spherical equivalent refractive error in human infants between 3 and 9 months of age...
  26. ncbi Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study
    Suresh Kumar Gupta
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
    Nutrition 19:794-9. 2003
    ..Lycopene, a nutritional antioxidant, was evaluated for its anticataract potential to further establish its role in cataract prevention...
  27. pmc Violet and blue light blocking intraocular lenses: photoprotection versus photoreception
    M A Mainster
    PhD, MD, FRCOphth, Department of Ophthalmology, MS3009, University of Kansas Medical School, 3901 Rainbow Boulevard, Kansas City, KS 66160 7379, USA
    Br J Ophthalmol 90:784-92. 2006
    ..To analyse how intraocular lens (IOL) chromophores affect retinal photoprotection and the sensitivity of scotopic vision, melanopsin photoreception, and melatonin suppression...
  28. ncbi Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation
    Pei Rong
    Department of Cell Biology, The Scripps Research Institute, La Jolla, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 129:167-74. 2002
    ..More importantly, a delayed denucleation process was observed in the interior fibers of the alpha8-/- lenses. Therefore, alpha8 connexin is required for proper fiber cell maturation and control of lens size...
  29. ncbi Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
    A Shiels
    Departments of Ophthalmology and Visual Sciences, Genetics, Cell Biology Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 7:179-86. 2001
    ..These findings show that heterozygous loss of AQP0 is sufficient to trigger cataractogenesis in mice and suggest that this MIP is required for optimal focusing of the crystalline lens.
  30. ncbi OXYS rats as a model of senile cataract
    N G Kolosova
    Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk
    Bull Exp Biol Med 136:415-9. 2003
    ..Cataract in OXYS rats corresponds to senile cataract, which makes this rat strain a unique model for studies of the pathogenesis of involutive cataract and elaboration of methods for its prevention and correction...
  31. ncbi Autosomal dominant coralliform cataract related to a missense mutation of the gammaD-crystallin gene
    Wei Zhen Xu
    Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
    Chin Med J (Engl) 117:727-32. 2004
    ..About 25% of all cases are due to genetic defects. We identified autosomal dominant congenital coralliform cataracts-related genetic defect in a four-generation Chinese family...
  32. ncbi Regulation of aquaporin water permeability in the lens
    Kulandaiappan Varadaraj
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, USA
    Invest Ophthalmol Vis Sci 46:1393-402. 2005
    ..To examine Ca(2+)- and pH-mediated regulation of water permeability of endogenously expressed aquaporin (AQP)0 in lens fiber cells and AQP1 in lens epithelial cells...
  33. ncbi AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach
    J P Brady
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 2730, USA
    Invest Ophthalmol Vis Sci 42:2924-34. 2001
    ..To study the role of alphaB-crystallin (alphaB) in the developing lens and its importance in lens structure and function...
  34. pmc Pax6 is essential for lens fiber cell differentiation
    Ohad Shaham
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Development 136:2567-78. 2009
    ..This study reveals that Pax6 is pivotal for initiation of the lens fiber differentiation program in the mammalian eye...
  35. ncbi Crystalline lens optical dysfunction through aging
    Jorge L Alio
    Research, Development, and Innovation Department, VISSUM, Instituto Oftalmologico de Alicante, Alicante, Spain
    Ophthalmology 112:2022-9. 2005
    To evaluate the optical and densitometric changes that take place in the crystalline lens with aging.
  36. ncbi The influence of diabetes mellitus type 1 and 2 on the thickness, shape, and equivalent refractive index of the human crystalline lens
    Nanouk G M Wiemer
    Department of Ophthalmology, VU University Medical Center, Amsterdam, The Netherlands
    Ophthalmology 115:1679-86. 2008
    ..To study the influence of diabetes mellitus (DM) types 1 and 2 on the thickness, radius of curvature, equivalent refractive index, and power of the lens...
  37. ncbi Otx genes are required for tissue specification in the developing eye
    J R Martinez-Morales
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 128:2019-30. 2001
    ....
  38. ncbi Femtosecond lentotomy: generating gliding planes inside the crystalline lens to regain accommodation ability
    Holger Lubatschowski
    Laser Zentrum Hannover eV, Hannover, Germany
    J Biophotonics 3:265-8. 2010
    ..Existing therapies, however, do not reverse the stiffness of the crystalline lens and thus do not regain real accommodation ability...
  39. ncbi Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation
    R U de Iongh
    Department of Anatomy and Histology, The University of Sydney, NSW 2006, Australia
    Development 128:3995-4010. 2001
    ..These results indicate that TGFbeta signaling is a key event during fiber differentiation and is required for completion of terminal differentiation...
  40. ncbi The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development
    L J Dong
    Department of Biological Sciences, University of Pittsburgh, PA 15260
    Differentiation 48:157-72. 1991
    ....
  41. ncbi The role of Pax-6 in eye and nasal development
    J C Grindley
    Developmental Genetics Section, Western General Hospital, Edinburgh, UK
    Development 121:1433-42. 1995
    ....
  42. ncbi Expression of a truncated FGF receptor results in defective lens development in transgenic mice
    M L Robinson
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 121:3959-67. 1995
    ..Our results support the view that FGF receptor signalling plays an essential role in normal lens biology...
  43. ncbi FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens
    R L Chow
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Development 121:4383-93. 1995
    ..These results show that lens fibre cells are dependent on FGF for their survival and differentiation, and demonstrate that growth factor deprivation in vivo can lead to apoptosis...
  44. pmc Changes in crystalline lens radii of curvature and lens tilt and decentration during dynamic accommodation in rhesus monkeys
    Patricia Rosales
    Instituto de Optica, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Vis 8:18.1-12. 2008
    Dynamic changes in crystalline lens radii of curvature and lens tilt and decentration were measured during centrally stimulated accommodation in four iridectomized eyes of two adolescent rhesus monkeys...
  45. ncbi Stiffness gradient in the crystalline lens
    Henk A Weeber
    AMO, Van Swietenlaan 5, 9728 NX Groningen, The Netherlands
    Graefes Arch Clin Exp Ophthalmol 245:1357-66. 2007
    ..The purpose of this study was to determine the stiffness gradient in the human crystalline lens. A secondary purpose was to determine whether the stiffness gradient depends on age.
  46. ncbi Bi-directional migration of lens epithelial cells in a physiological electrical field
    Entong Wang
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, UK
    Exp Eye Res 76:29-37. 2003
    ..The MAP kinase inhibitor U0126 prevented activation of ERK1/2 in LECs and inhibited EF-directed migration, implicating MAP kinase signaling in directing the migration of LECs in a physiological EF...
  47. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals...
  48. ncbi The mechanism of presbyopia
    Susan A Strenk
    Department of Surgery, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08855, USA
    Prog Retin Eye Res 24:379-93. 2005
    ....
  49. pmc TGFbeta-Smad signalling in postoperative human lens epithelial cells
    S Saika
    Department of Ophthalmology, Wakayama Medical University, Japan
    Br J Ophthalmol 86:1428-33. 2002
    ..Smads3/4 are involved in signal transduction between transforming growth factor beta (TGFbeta) cell surface receptors and gene promoters. Nuclear localisation of Smads indicates achievement of endogenous TGFbeta signalling in cells...
  50. pmc Lens aging: effects of crystallins
    K Krishna Sharma
    Department of Ophthalmology, University of Missouri Columbia, 1 Hospital Drive, Columbia, MO 65212, USA
    Biochim Biophys Acta 1790:1095-108. 2009
    ..We also review hyperbaric oxygen treatment induced guinea pig and 'humanized' ascorbate transporting mouse models as suitable options for studies on age-related changes in lens proteins...
  51. ncbi Functional impairment of lens aquaporin in two families with dominantly inherited cataracts
    P Francis
    Department of Molecular Genetics, Institute of Ophthalmology, University College and Moorfields Eye Hospital, 11 43 Bath Street, London EC1V 9EL, UK
    Hum Mol Genet 9:2329-34. 2000
    Opacities in the crystalline lens of eye appear with high frequency in the general population...
  52. pmc Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 25:5383-95. 2006
    ..We conclude that Six3 directly activates Pax6 and probably also Sox2 in the PLE and regulates cell autonomously the earliest stages of mammalian lens induction...
  53. pmc Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70
    T W White
    Program in Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Biol Cell 3:711-20. 1992
    The crystalline lens is an attractive system to study the biology of intercellular communication; however, the identity of the structural components of gap junctions in the lens has been controversial...
  54. pmc Gene expression signatures in the newt irises during lens regeneration
    Evgeny Makarev
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469 2320, USA
    FEBS Lett 581:1865-70. 2007
    ..Such transcriptional activity in the regeneration-incompetent ventral iris was unexpected and calls for a revision of our views about mechanisms of lens regeneration induction...
  55. pmc A proteome map of the zebrafish (Danio rerio) lens reveals similarities between zebrafish and mammalian crystallin expression
    Mason Posner
    Department of Biology, Ashland University, Ashland, OH 2Department of Chemistry, Ashland University, Ashland, OH 44805, USA
    Mol Vis 14:806-14. 2008
    ..To characterize the crystallin content of the zebrafish lens using two-dimensional gel electrophoresis (2-DE). These data will facilitate future investigations of vertebrate lens development, function, and disease...
  56. ncbi Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice
    Haotian Zhao
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, Ohio 43205, USA
    Invest Ophthalmol Vis Sci 45:1930-9. 2004
    ..The purpose of the present study was to generate promoters capable of directing transgene expression to the entire lens but not to the corneal epithelium...
  57. ncbi Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2
    Fu Shang
    JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:521-30. 2003
    ..Moreover, levels of these nutrients must be optimized to achieve the maximal benefit...
  58. ncbi H(2)O(2)-mediated oxidative stress activates NF-kappa B in lens epithelial cells
    E J Dudek
    Laboratory for Nutrition and Vision Research, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 31:651-8. 2001
    ..These different pathways of NF-kappa B activation may be required to effect specific NF-kappa B-dependent gene expression in response to these different stimuli...
  59. ncbi Ultraviolet radiation modulates nuclear factor kappa B activation in human lens epithelial cells
    Thomas W M Boileau
    Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Biochem Mol Toxicol 17:108-13. 2003
    ..The activation of NF-kappa B in HLE cells by UVAR may have implications for the development and progression of cataract and other related ocular disorders...
  60. ncbi Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts
    D P Singh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 267:373-81. 2000
    ..Also in serum-free medium, Ab to LEDGF neutralizing LEDGF blocked cell growth and caused cell death. Thus, LEDGF, a regulatory factor, may play an important role for growth and survival of a wide range of cell types...
  61. pmc Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
    P Zhang
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461 USA
    Genes Dev 12:3162-7. 1998
    ..These studies demonstrate that p27(KIP1) and p57(KIP2) are critical terminal effectors of signal transduction pathways that control cell differentiation...
  62. ncbi Oxygen distribution in the rabbit eye and oxygen consumption by the lens
    Ying Bo Shui
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 47:1571-80. 2006
    ..For a better understanding of the metabolism of oxygen in the eye, oxygen distribution was mapped in the intraocular fluids, and the rate of oxygen consumption by the lens in rabbits breathing different levels of oxygen was calculated...
  63. ncbi Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome
    P Zhang
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 387:151-8. 1997
    ....
  64. ncbi Glutathione-related enzymes and the eye
    Elena Ganea
    Institute of Biochemistry, Splaiul Independentei 296, Bucharest, Romania
    Curr Eye Res 31:1-11. 2006
    ..Changes of glutathione and related enzymes activity in lens, cornea, retina and other eye tissues, occur with ageing, cataract, diabetes, irradiation and administration of some drugs...
  65. ncbi Caspase remodeling of the spectrin membrane skeleton during lens development and aging
    A Lee
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:20735-42. 2001
    ..Partial and specific proteolysis of membrane skeleton components by caspases may be important for age-related membrane changes in the lens...
  66. ncbi Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses
    P S Padayatti
    Center for Vision Research, Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA
    Invest Ophthalmol Vis Sci 42:1299-304. 2001
    ..All crystallins contained argpyrimidine and covalently cross-linked aggregates. This is the first report of immunologic evidence for an arginine modification in the human lens by a physiologically important alpha-dicarbonyl compound...
  67. pmc The EPHA2 gene is associated with cataracts linked to chromosome 1p
    Alan Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 14:2042-55. 2008
    ....
  68. ncbi Connexin50 is essential for normal postnatal lens cell proliferation
    Caterina Sellitto
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York, 11794 8661, USA
    Invest Ophthalmol Vis Sci 45:3196-202. 2004
    ..Deletion of Cx50 or replacement with Cx46 by knockin resulted in smaller lenses containing fewer cells. To determine why Cx50-deficient lenses fail to grow normally, cell proliferation was assayed during the period of growth failure...
  69. ncbi Hedgehog signalling controls eye degeneration in blind cavefish
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nature 431:844-7. 2004
    ..These features can be mimicked in surface fish by twhh and/or shh overexpression, supporting the role of hh signalling in the evolution of cavefish eye regression...
  70. pmc Downregulation of MMP-2 and -9 by proteasome inhibition: a possible mechanism to decrease LEC migration and prevent posterior capsular opacification
    Niranjan Awasthi
    Departments of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Invest Ophthalmol Vis Sci 49:1998-2003. 2008
    ..The present study investigates the prevention of LEC migration by proteasome inhibition through the suppression of matrix metalloproteinase (MMP) expression and activity...
  71. ncbi The spectral sensitivity of the lens eyes of a box jellyfish, Tripedalia cystophora (Conant)
    Melissa M Coates
    Hopkins Marine Station, Department of Biological Sciences, Stanford University, Oceanview Boulevard, Pacific Grove, California 93950, USA
    J Exp Biol 209:3758-65. 2006
    ..The peak sensitivity is to blue-green light. Visual pigment template fits indicate a vitamin A-1 based opsin with peak sensitivity near 500 nm for both eye types...
  72. pmc Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform
    Yajun Tang
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Invest Ophthalmol Vis Sci 48:2685-94. 2007
    ..In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice...
  73. pmc Development of a macromolecular diffusion pathway in the lens
    Valery I Shestopalov
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Cell Sci 116:4191-9. 2003
    ..At all ages examined, a significant proportion of the nucleated fiber cell population of the lens was located within this region of the lens...
  74. ncbi In vivo study of changes in refractive index distribution in the human crystalline lens with age and accommodation
    Sanjeev Kasthurirangan
    Schools of Optometry, Queensland University of Technology, Brisbane, Australia
    Invest Ophthalmol Vis Sci 49:2531-40. 2008
    ..Magnetic resonance imaging (MRI) was used to map the refractive index distribution in human eye lenses in vivo and to investigate changes with age and accommodation...
  75. ncbi Genetic background influences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice
    Dwan A Gerido
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    Invest Ophthalmol Vis Sci 44:2669-74. 2003
    ....
  76. pmc Properties of gap junction channels formed by Cx46 alone and in combination with Cx50
    M G Hopperstad
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biophys J 79:1954-66. 2000
    ..We conclude that different combinations of Cx46 and Cx50 within gap junction channels lead to unique biophysical properties...
  77. ncbi Biometric, optical and physical changes in the isolated human crystalline lens with age in relation to presbyopia
    A Glasser
    College of Optometry, University of Houston, TX 77204, USA
    Vision Res 39:1991-2015. 1999
    ....
  78. ncbi TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation
    Dong Myung Shin
    Department of Biochemistry and Molecular Biology AARC, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    FASEB J 22:2498-507. 2008
    ..Therefore, TGFbeta-TGase2 pathway may have implications for both the pathogenesis of age-related degenerative diseases and the development of pharmaceutics...
  79. ncbi [Prematurely aging OXYS rats as an animal model of senile cataract in human]
    N G Kolosova
    Institute of Cytology and Genetics, Novosibirsk Branch of MNTK Microsurgery of the Eye, State Novosibirsk Regional Clinical Hospital, Novosibirsk State Medical Academy, Novosibirsk, Russia
    Adv Gerontol 12:143-8. 2003
    ..The data suggest that the cataract in rats OXYS develops simultaneously with progressive macular degeneration while changes of the eye lenses morphologically correspond to senile cataract in man...
  80. pmc The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation
    Ramya Rajagopal
    Departments of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63110, USA
    Dev Biol 335:305-16. 2009
    ..A key function of Smad-independent BMP receptor signaling may be reorganization of actin cytoskeleton to drive lens invagination...
  81. pmc Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Am J Pathol 164:651-63. 2004
    ..The results suggest that blocking the Smad3 pathway might be beneficial in inhibiting capsular fibrosis after injury and/or surgery...
  82. ncbi Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
    S C Neuhauss
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, D 72076 Tubingen, Germany
    J Neurosci 19:8603-15. 1999
    ..The mutations uncovered by our behavioral assays provide distinct entry points for the study of visual pathways and set the stage for a genetic dissection of vertebrate vision...
  83. ncbi Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage
    Jasminka Mizdrak
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
    Free Radic Biol Med 44:1108-19. 2008
    ..These data indicate that the covalent modification of lens proteins by Kyn derivatives yields photosensitizers that may enhance oxidation in older lenses and contribute to age-related nuclear cataract...
  84. ncbi Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses
    Anastasia Korlimbinis
    Save Sight Institute, University of Sydney, GPO Box 4337, Sydney, NSW 2001, Australia
    Exp Eye Res 85:219-25. 2007
    ....
  85. ncbi Changes in physicochemical parameters and alpha-crystallin expression in the lens during cataract development in OXYS rats. 5
    Yu V Rumyantseva
    Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia
    Biochemistry (Mosc) 73:1176-82. 2008
    ..The changes observed in OXYS rats are evidently associated with the dystrophic changes in lens epithelium, which we have described earlier, and are consistent with the model of senile cataract...
  86. pmc Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development
    Y Kamachi
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Dev 15:1272-86. 2001
    ....
  87. ncbi Molecular identification and characterisation of the glycine transporter (GLYT1) and the glutamine/glutamate transporter (ASCT2) in the rat lens
    Julie Lim
    Department of Physiology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Eye Res 83:447-55. 2006
    ..Moreover, the presence of ASCT2 in the centre of the lens raises the possibility that ASCT2 may work with the Xc(-) exchanger to accumulate cysteine where it can potentially act as a low molecular mass antioxidant...
  88. pmc ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory
    Matthew Grove
    Duke University Medical Center, Department of Pharmacology and Cancer Biology, Box 3813, Durham, NC 27710, USA
    Mol Cell Biol 24:10905-22. 2004
    ..These findings support a role for Abi2 in the regulation of cytoskeletal dynamics at adherens junctions and dendritic spines, which is critical for intercellular connectivity, cell morphogenesis, and cognitive functions...
  89. ncbi Thiol regulation in the lens
    M F Lou
    Center for Biotechnology, Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln 68583 0905, USA
    J Ocul Pharmacol Ther 16:137-48. 2000
    ..We conclude that TTase can regulate and repair the thiols in lens proteins and enzymes through its dethiolase activity, thus contributing to the maintenance of the function of the lens...
  90. ncbi Glutathione: a vital lens antioxidant
    F J Giblin
    Eye Research Institute, Oakland University, Rochester, Michigan 48309 4401, USA
    J Ocul Pharmacol Ther 16:121-35. 2000
    ..A need exists for development of therapeutic agents to slow age-related loss of antioxidant activity in the nucleus of the human lens to delay the onset of cataract...
  91. ncbi Epithelial transdifferentiation and cataract in the human lens
    J M Marcantonio
    School of Biological Sciences, University of East Anglia, NR4 7TJ, Norwich, UK
    Exp Eye Res 77:339-46. 2003
    ..Cataract, and especially cortical cataract, should therefore be seen as associated with stress-induced signalling pathways in the lens that lead to the transdifferentiation of the anterior epithelial cells...
  92. pmc HSF4 is required for normal cell growth and differentiation during mouse lens development
    Mitsuaki Fujimoto
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    EMBO J 23:4297-306. 2004
    ....
  93. pmc Gene expression profiles of lens regeneration and development in Xenopus laevis
    Erica L Malloch
    University of Illinois, Department of Cell and Developmental Biology, Urbana, Illinois 61801, USA
    Dev Dyn 238:2340-56. 2009
    ..Several novel genes specifically expressed in lenses were identified. The suite of genes was compared to those up-regulated in other regenerating tissues/organisms, and a small degree of overlap was detected...
  94. pmc In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92
    V N Lapko
    Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588 0304, USA
    Protein Sci 10:1130-6. 2001
    ..These results are also the first documentation of in vivo lysine acetylation of alphaB-crystallin. Both modifications alter the net charge on alphaB-crystallin, a feature that may have significance to cataractogenesis...
  95. pmc Mitochondrial superoxide dismutase activation with 17 beta-estradiol-treated human lens epithelial cells
    Srinivas Gottipati
    Department of Cell Biology and Genetics, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Mol Vis 14:898-905. 2008
    ....
  96. ncbi Suppression of human lens epithelial cell proliferation by proteasome inhibition, a potential defense against posterior capsular opacification
    Niranjan Awasthi
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey UMDNJ, New Jersey Medical School, Newark, NJ 07101 1709, USA
    Invest Ophthalmol Vis Sci 47:4482-9. 2006
    ..Studies have shown that proteasome inhibition interferes with EMT and remodeling of the extracellular matrix. This study was conducted to investigate suppression of LEC proliferation by proteasome inhibition and its signaling pathway...
  97. ncbi The in vivo phosphorylation sites of bovine alpha B-crystallin
    C E Voorter
    Department of Biochemistry, University of Nijmegen, The Netherlands
    FEBS Lett 259:50-2. 1989
    ..This pattern of phosphorylation differs from the previously reported in vitro obtained results...
  98. ncbi Gradient refractive index of the crystalline lens of the Black Oreo Dory (Allocyttus Niger): comparison of magnetic resonance imaging (MRI) and laser ray-trace methods
    L F Garner
    Department of Optometry and Vision Science, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Vision Res 41:973-9. 2001
    The gradient refractive index of the crystalline lens in the Black Oreo Dory (Allocyttus Niger) was determined using two methods; an optimisation program based on finite ray-tracing and the path of laser beams through the lens, and ..
  99. ncbi Prenatal lens development in connexin43 and connexin50 double knockout mice
    T W White
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    Invest Ophthalmol Vis Sci 42:2916-23. 2001
    ..To determine the roles of intercellular communication in embryonic eye growth and development, mice with a targeted deletion of the Cx43 gene were examined, and mice without both Cx43 and Cx50 were generated and analyzed...
  100. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
    ....
  101. pmc Ex vivo magnetic resonance imaging of crystalline lens dimensions in chicken
    Rebecca J Tattersall
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Mol Vis 16:144-53. 2010
    A reduction in the power of the crystalline lens during childhood is thought to be important in the emmetropization of the maturing eye...

Research Grants63

  1. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ..Age-dependent changes in the crystalline lens lead to reduced contrast and poorer spatial resolution...
  2. In Vivo Evaluation of Presbyopia
    Kathryn Richdale; Fiscal Year: 2013
    ..coherence tomography, magnetic resonance imaging, and ultrasound-based techniques will be used to examine the crystalline lens, ciliary body, and geometric relationship of the structures...
  3. Guiding the Treatment of Anterior Eye Disease with Optical Coherence Tomography
    David Huang; Fiscal Year: 2013
    ..The goal is to provide reliable measurements on front and back surfaces of both the cornea and crystalline lens. (2) To develop an OCT-based intraocular lens power formula...
  4. ACCOMMODATIVE CONTACT LENs FOR PRESBYOPIC CORRECTION
    Hongrui Jiang; Fiscal Year: 2011
    ..This tunable lens cooperates with the cornea and the crystalline lens to ensure comfortable vision at any distance starting from the normal, youthful near point...
  5. Optical coherence tomography equipped wavefront system for studying accommodation
    Ji chang He; Fiscal Year: 2013
    ..process called accommodation, by which refractive power is varied due to a deformation of the shape of the crystalline lens, brought about by a contraction of the ciliary muscle...
  6. Curvature Changing Accommodating IOL
    James T Schwiegerling; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Presbyopia is an age-related disorder in which the crystalline lens becomes less flexible, leading to an inability to focus on near objects...
  7. Genetic determinants of cataract
    Alan Shiels; Fiscal Year: 2013
    Project Summary The crystalline lens plays a central role in vertebrate anterior eye development and refractive vision...
  8. TRACE ELEMENT NUTRITION OF THE LENS--ZINC
    J Bentley; Fiscal Year: 1990
    ..to determine the distribution, metabolism and physiological roles of the essential trace element zinc in the crystalline lens, especially with respect to the maintenance of its transparency and the prevention of cataracts...
  9. Redefining the Model of the Blood-Aqueous Barrier
    Thomas Freddo; Fiscal Year: 2005
    ..model proves robust, it would change fundamental assumptions about the biological environment surrounding the crystalline lens and within the trabecular meshwork...
  10. Optics of the Growing Crystalline Lens
    Fabrice Manns; Fiscal Year: 2013
    ..in response to PA-10-009, Bioengineering Research Grants, is to understand how the continuous growth of the crystalline lens throughout the life span contributes to changes in the optical quality of the eye...
  11. Adjustable Injectable Intraocular Lens
    Shiao Chang; Fiscal Year: 2004
    ..is a progressive, age-related loss of accommodation characterized by the loss of the ability of the natural crystalline lens to change its shape to enable focusing at varying distances...
  12. Sensory-Motor Control of the Binocular Near Response
    Clifton M Schor; Fiscal Year: 2012
    ..youthful accommodative dynamics in response to age-related changes in visco-elastic properties of the crystalline lens, (2) the influence of adapting dynamic accommodation and convergence on their dynamic cross-coupled ..
  13. Shack-Hartmann Corneal Topographer and Aberrometer
    DANIEL NEAL; Fiscal Year: 2005
    ..description of the refractive properties of the anterior cornea, the whole eye, and (by inference) the crystalline lens. This optical description will include not only the routine refractive errors of myopia, hyperopia, and ..
  14. Shack-Hartman Corneal Topographer and Aberrometer
    Larry Thibos; Fiscal Year: 2002
    ..description of the refractive properties of the anterior cornea, the whole eye, and (by inference the crystalline lens. This optical description will include not only the routine refractive errors of defocus and astigmatism ..
  15. Crystalline lens optics in accommodation and presbyopia
    BIANCA MARIA MACEO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The objective of the project is to characterize the optics of the human crystalline lens and to understand its contribution to accommodation and presbyopia...
  16. Accommodative changes in aging eyes
    Adrian Glasser; Fiscal Year: 2006
    ..Studies on humans and monkeys show age changes in both the crystalline lens and the extralenticular accommodative apparatus...
  17. Multiscale Modeling of Accommodation and Presbyopia
    JANE KORETZ; Fiscal Year: 2009
    ..Aim 1 is to create an updated and expanded analytic biomechanical model of the crystalline lens and ciliary muscle in human accommodation, using well-defined strain tensor elements as the basis for inverse ..
  18. Photochromic Intraocular Lenses
    Stephen Zhou; Fiscal Year: 2007
    ..Yellow IOLs, which absorb blue-light, mimic the transmission characteristics of an aged human crystalline lens, protect lipofucsin-containing retinal pigment epithelial cells from being damaged by blue-light...
  19. Brillouin Microscope for Tissue and Biomaterials
    Seok Yun; Fiscal Year: 2009
    ..The third specific aim is to measure the viscoelastic properties of the crystalline lens, cornea, and vitreous in mice and monitor their age-dependent changes in vivo longitudinally...
  20. RAMAN SPECTROSCOPY OF THE LENS OF THE EYE
    RONALD SCHACHAR; Fiscal Year: 1980
    ..yields significant information on both structural and chemical properties of the intact transparent crystalline lens. We have determined that Raman spectroscopy can be successfully applied to study cataractogenesis...
  21. OCULAR PHARMACOKINETICS OF FLUORESCENT DRUG ANALOGUES
    David Maurice; Fiscal Year: 1991
    ..Measurements of the kinetics of the fluorophores in the crystalline lens will be included in the measurements on the intact rabbit in order to determine to what extent it can serve ..
  22. LENS MEMBRANE IN RELATION TO HUMAN CATARACTOGENESIS
    Larry J Takemoto; Fiscal Year: 2010
    ..Using these novel methods, we will be able to ascertain the existence of these interactions and their possible alterations during lens opacification. ..
  23. ELECTRON MICROSCOPIC STUDIES OF CRYSTALLINE LENSES
    Jer Kuszak; Fiscal Year: 2006
    ..abstract_text> ..
  24. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  25. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  26. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  27. OCULAR DEVELOPMENT IN INFANCY/EARLY CHILDHOOD
    Donald Mutti; Fiscal Year: 2005
    ..measurement of refractive error, accommodative response, corneal curvature, anterior chamber depth, crystalline lens thickness and surface curvatures, vitreous chamber depth, and axial length in the original BIBS participants ..
  28. Role of Rho Kinase in Aqueous Humor Outflow Pathway
    P Rao; Fiscal Year: 2004
    ..Identification of specific signaling mechanisms regulating function of outflow pathway tissues could enable the design of target-specific approaches to the treatment of glaucoma. ..
  29. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  30. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
    ..abstract_text> ..
  31. A Method To Study Membrane Protein Structure
    Guido Zampighi; Fiscal Year: 2003
    ....
  32. AGE AND CATARACT RELATED CHANGES IN LENS PROTEINS
    Jack Liang; Fiscal Year: 2002
    ..The knowledge obtained from this proposal may provide insight on cataract formation on a molecular level and may help in formulating a strategy for developing anticataract agents. ..
  33. Mapping interaction surface domains in lens crystallins
    Jack Liang; Fiscal Year: 2008
    ..The long-term objective is to understand the mechanisms of dimerization and oligomerization, and the results may help us to understand the function of alpha-crystallin in normal lens and in cataract formation. ..
  34. OXIDATIVE STRESS AND CATARACT FORMATION
    Shambhu D Varma; Fiscal Year: 2010
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  35. TECNIA 12 BioTWIN Transmission Electron Microscope
    Guido Zampighi; Fiscal Year: 2003
    ..abstract_text> ..
  36. Transfection of Lens Cells with Phakinin Mutants
    MARK IRELAND; Fiscal Year: 2006
    ..The results of these studies will lead to a better understanding of beaded filament function and the etiology of some forms of cataract. ..
  37. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2004
    ..This study proposes to test the potential usefulness of enhancing myo-inositol efflux through chloride channels as a means for drug therapy to relieve intrafiber osmotic stress. ..
  38. LENS MEMBRANE STEROID BINDING PROTEIN (MSRP)
    RICHARD CENEDELLA; Fiscal Year: 2002
    ..Preliminary findings and published data support the possibility that steroids can rapidly elevate intracellular calcium and inhibit Na+/K+-ATPase activity in lens epithelial cells. ..
  39. BIOPHYSICAL CHARACTERIZATION OF ALPHA CRYSTALLIN
    JANE KORETZ; Fiscal Year: 2001
    DESCRIPTION: Alpha-crystallin, tha major protein component of the crystalline lens of mammalian eyes , exist in the lens cytoplasm as aggregates of approximately 40 subunits in an isoform mixture of 3A:1B in the human...
  40. GENE EXPRESSION IN NORMAL AND CATARACTOUS LENS
    Suraj P Bhat; Fiscal Year: 2010
    ....
  41. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ....
  42. GENE MANIPULATION & H202 DEGRADATION IN THE OCULAR LENS
    Abraham Spector; Fiscal Year: 2001
    ..This is the first finding of tyrosine phosphorylation of the crystallins. We intend to further confirm this observation and attempt to determine the effect of such phosphorylation. ..
  43. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  44. Lens Cholesterol Metobolism and the U1866A Cataract.
    RICHARD CENEDELLA; Fiscal Year: 2005
    ..These are obvious benefits to public health considering the intended life-long use of the drugs. ..
  45. Third Symposium Cell Volume & Signalling Regulation
    PETER LAUF; Fiscal Year: 2003
    ..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
  46. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  47. Analysis of transcription in lens using tiled microarrays (ChIP on chip)
    Ales Cvekl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  48. CLONING THE GENE FOR BLEPHAROPHIMOSIS SYNDROME
    Suraj Bhat; Fiscal Year: 2003
    ..This project would contribute information towards the NEI program goal to "understand how the visual system is assembled during development, how its assembly is influenced by endogenous and exogenous factors." ..
  49. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  50. EYE GROWTH DURING INFANCY
    Scott Lambert; Fiscal Year: 2001
    ..we will assay infantile eyes for changes in certain neurotransmitters and growth factors after removing the crystalline lens which we have previously shown retards ocular growth...
  51. COLLABORATIVE LONGITUDINAL EVALUATION KERATOCONUS STUDY
    Karla Zadnik; Fiscal Year: 2004
    ..Louis, Missouri, and the CLEK Photography Reading Center at The Ohio State University College of Optometry, Columbus, Ohio. ..
  52. Multi-Resolution Corneal Topography (MRCT)
    EDWIN SARVER; Fiscal Year: 2006
    ..research grant ..
  53. Vision Research Infrastructure Development Grant (R24)
    FRANK GIBLIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  54. GLUCOCORTICOID RECEPTOR-MEDIATED CATARACT
    Eric James; Fiscal Year: 2003
    ....
  55. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  56. MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENT
    Jonathan J Henry; Fiscal Year: 2010
    ....
  57. Gene expression and retinal vascularization
    John Ash; Fiscal Year: 2004
    ..By identifying new candidate proteins, this project would feed into our long-range goals of identifying proteins that are essential regulators of retinal vascular development. ..