kidney tubules

Summary

Top Publications

  1. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
  2. pmc Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
    Courtney M Karner
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Genet 41:793-9. 2009
  3. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
  4. ncbi Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 17:17-25. 2006
  5. pmc Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension
    Soeren S Lienkamp
    Department of Medicine, Renal Division, University of Freiburg Medical Center, Freiburg, Germany
    Nat Genet 44:1382-7. 2012
  6. ncbi Stromal cells protect against acute tubular injury via an endocrine effect
    Baoyuan Bi
    Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Am Soc Nephrol 18:2486-96. 2007
  7. ncbi Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
    Maria P Rastaldi
    Renal Research Association, Renal Immunopathology Centre, San Carlo Borromeo Hospital, Via Pio II, 3, 20153 Milan, Italy
    Kidney Int 62:137-46. 2002
  8. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
  9. pmc Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis
    Matheus Corrêa-Costa
    Laboratory of Clinical and Experimental Immunology, Nephrology Division, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    PLoS ONE 5:e14298. 2010
  10. pmc Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    J Yang
    Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1465-75. 2001

Detail Information

Publications283 found, 100 shown here

  1. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
    ..These data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease...
  2. pmc Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
    Courtney M Karner
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Genet 41:793-9. 2009
    ..Although previous studies showed that polarized cell divisions maintain the diameter of postnatal kidney tubules, we find that cell divisions are randomly oriented during embryonic development...
  3. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
    ..These data imply that TLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury...
  4. ncbi Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 17:17-25. 2006
    ..This has given hope for the development of novel therapeutic approaches against this final common pathway...
  5. pmc Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension
    Soeren S Lienkamp
    Department of Medicine, Renal Division, University of Freiburg Medical Center, Freiburg, Germany
    Nat Genet 44:1382-7. 2012
    ..These data resolve long-standing questions concerning the role of PCP signaling in the developing kidney and, moreover, establish rosette-based intercalation as a deeply conserved cellular engine for epithelial morphogenesis...
  6. ncbi Stromal cells protect against acute tubular injury via an endocrine effect
    Baoyuan Bi
    Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Am Soc Nephrol 18:2486-96. 2007
    ..Identification of the stromal cell-derived protective factors may provide new therapeutic options to explore in humans with acute kidney injury...
  7. ncbi Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
    Maria P Rastaldi
    Renal Research Association, Renal Immunopathology Centre, San Carlo Borromeo Hospital, Via Pio II, 3, 20153 Milan, Italy
    Kidney Int 62:137-46. 2002
    ..According to this theory, they should proceed through several activating steps, such as proliferation and phenotype changes, to eventually synthesize extracellular matrix (ECM)...
  8. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  9. pmc Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis
    Matheus Corrêa-Costa
    Laboratory of Clinical and Experimental Immunology, Nephrology Division, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    PLoS ONE 5:e14298. 2010
    ..Heme-oxygenase-1 (HO-1) is a cytoprotective molecule that has been shown to be beneficial in various models of renal injury. However, the role of HO-1 in reversing an established renal scar has not yet been addressed...
  10. pmc Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    J Yang
    Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1465-75. 2001
    ....
  11. pmc Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
    ..confirm internalization of apoptotic bodies within KIM-1-expressing epithelial cells after injury in rat kidney tubules in vivo...
  12. ncbi Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 68:2714-25. 2005
    ..Here, we tested the hypothesis that cobalt administration not only attenuates acute ischemic insult, but also ameliorates tubulointerstitial injury secondary to chronic hypoxia...
  13. ncbi The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
    R E Gilbert
    University of Melbourne, Department of Medicine, West Heidelberg, Victoria, 3081, Australia
    Kidney Int 56:1627-37. 1999
    ..Continued exploration into tubulointerstitial disease in addition to glomerular injury in diabetes may help provide further insights into the pathogenesis of diabetic nephropathy and additional targets for therapeutic intervention...
  14. ncbi Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro
    J M Fan
    Department of Nephrology, The First Hospital, Western China University of Medical Sciences, Chengdu
    Kidney Int 56:1455-67. 1999
    ..We recently found evidence of tubular epithelial-myofibroblast transdifferentiation (TEMT) during the development of tubulointerstitial fibrosis in the rat remnant kidney. This study investigated the mechanisms that induce TEMT in vitro...
  15. ncbi Intrinsic epithelial cells repair the kidney after injury
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Cell Stem Cell 2:284-91. 2008
    ..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney...
  16. pmc Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney
    Fangming Lin
    Department of Pediatrics and Department of Internal Medicine and Division of Basic Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 5390 9063, USA
    J Clin Invest 115:1756-64. 2005
    ..These results show that intrarenal cells are the main source of renal repair, and a single injection of BMCs does not make a significant contribution to renal functional or structural recovery...
  17. pmc Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
    Stefania Bruno
    Department of Internal Medicine, Research Center for Experimental Medicine, University of Torino, Torino, Italy
    J Am Soc Nephrol 20:1053-67. 2009
    ..These results suggest that microvesicles derived from MSCs may activate a proliferative program in surviving tubular cells after injury via a horizontal transfer of mRNA...
  18. ncbi Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
    D H Kang
    Division of Nephrology, University of Washington, Seattle, WA, USA
    J Am Soc Nephrol 12:1448-57. 2001
    ..58 +/- 3.45%, VEGF versus vehicle, P < 0.01). In conclusion, VEGF treatment reduces fibrosis and stabilizes renal function in the RK model. The use of angiogenic factors may represent a new approach to the treatment of kidney disease...
  19. pmc Inflammation in acute kidney injury
    Gilbert R Kinsey
    Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Nephron Exp Nephrol 109:e102-7. 2008
    ..This review summarizes these recent advances to further our understanding of the immune mechanisms of acute kidney injury...
  20. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
    ..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
  21. ncbi A novel simpler histological classification for renal survival in IgA nephropathy: a retrospective study
    Carlo Manno
    Department of Emergency and Organ Transplantation, Renal, Dialysis and Transplant Unit, University of Bari, Bari, Italy
    Am J Kidney Dis 49:763-75. 2007
    ..We evaluated factors associated with long-term renal survival by using a novel simplified histological classification...
  22. pmc Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction
    Yen Ta Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Transl Med 9:51. 2011
    ..We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury...
  23. ncbi Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury
    Marina Morigi
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Stem Cells 28:513-22. 2010
    ..Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI...
  24. ncbi Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis
    F Shiraishi
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida 32610, USA
    Am J Physiol Renal Physiol 278:F726-36. 2000
    ..These studies provide a basis for future studies using targeted gene expression of HO-1 as a therapeutic and preventive modality in high-risk settings of acute renal failure...
  25. ncbi An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease
    Omar García-Sánchez
    Unidad de Fisiopatología Renal y Cardiovascular, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain
    Kidney Int 77:950-5. 2010
    ..Furthermore, renal fibrosis, a TGF-beta-mediated event, is integrated as a potential, indirect effect contributing to tubule deletion...
  26. pmc Mediators of inflammation in acute kidney injury
    Ali Akcay
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80262, USA
    Mediators Inflamm 2009:137072. 2009
    ..Thus, inflammation has an important role in the initiation and extension phases of AKI. This review will focus on the mediators of inflammation contributing to the pathogenesis of AKI...
  27. pmc Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling
    Weichun He
    Department of Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    J Biol Chem 285:24665-75. 2010
    ..Collectively, these studies identify PAI-1 as a direct downstream target of Wnt/beta-catenin signaling and demonstrate that PAI-1 induction could play a role in mediating the fibrogenic action of this signaling...
  28. ncbi An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin
    Yaremi Quiros
    Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, 37007 Salamanca, Spain
    Toxicol Sci 119:245-56. 2011
    ..The purpose of this review was to critically integrate all these effects and discuss their relative contribution to tubular cell death...
  29. ncbi Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis
    Pilar Justo
    Unidad de Dialisis, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    J Am Soc Nephrol 14:3072-80. 2003
    ..However, endoplasmic reticulum-specific caspase-12 was not activated. CsA induces changes in several apoptotic pathways. However, the main lethal apoptotic pathway in CsA-exposed tubular epithelial cells involves mitochondrial injury...
  30. ncbi Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction
    Yasuhiro Suzuki
    Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 81:865-79. 2012
    ..Thus, TGF-β1 induces VEGF-C expression, which leads to lymphangiogenesis...
  31. pmc Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury
    Bing Li
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 121:2211-20. 2010
    ..We studied the capacity of human CD34(+) hematopoietic stem/progenitor cells (HSPCs) to promote kidney repair and regeneration using an established ischemia/reperfusion injury model in mice, with particular focus on the microvasculature...
  32. ncbi The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity
    So Young Lee
    Department of Internal Medicine, Eulji College of Medicine, Seoul, Korea
    Transplantation 78:1756-64. 2004
    ..This study evaluated the mechanism for CsA-induced tubular cell apoptosis, tubulointerstitial fibrosis and its associated proteins, and the therapeutic effects of alpha-melanocyte-stimulating hormone (MSH) on them...
  33. ncbi Pathways to nephron loss starting from glomerular diseases-insights from animal models
    Wilhelm Kriz
    Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 67:404-19. 2005
    ..The only option for extracapillary injuries with tuft adhesion is repair by formation of a segmental adherent scar (i.e., segmental glomerulosclerosis)...
  34. pmc Crumbs stabilises epithelial polarity during tissue remodelling
    Kyra Campbell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Cell Sci 122:2604-12. 2009
    ....
  35. ncbi Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4
    Kameswaran Surendran
    Department of Pediatrics, Division of Biology and Biomedical Sciences, Washington University School of Medicine, and Saint Louis Children s Hospital, Missouri 63110, USA
    Kidney Int 65:2212-22. 2004
    ..Matrilysin, a secreted matrix metalloproteinase and target gene of Wnt signaling, functions in epithelial repair and host defense, but no role in renal injury has been described...
  36. pmc Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
    Charuhas V Thakar
    Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    J Clin Invest 115:3451-9. 2005
    ..We propose that TSP-1 is a novel regulator of ischemic damage in the kidney and may play an important role in the pathophysiology of ischemic kidney failure...
  37. ncbi Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction
    Neil G Docherty
    Department of Surgery, Conway Institute of Biomolecular and Biomedical Sciences, Univ College Dublin, Belfield, Dublin 4, Republic of Ireland
    Am J Physiol Renal Physiol 290:F4-13. 2006
    ..Several interventions that reduce tubular apoptosis are discussed in terms of their ability to prevent subsequent progression to end-organ damage and fibrosis...
  38. ncbi NADPH oxidases in the kidney
    Pritmohinder S Gill
    Angiogenesis Section, Lombardi Cancer Center, Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, District of Columbia 20007, USA
    Antioxid Redox Signal 8:1597-607. 2006
    ..Experimental studies of the distribution, signaling, and function of NADPH oxidases in the kidney are described...
  39. pmc The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila
    Barry Denholm
    Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    Development 140:1100-10. 2013
    ..We demonstrate conservation in the expression of the family of tiptop/teashirt genes in lower insects and establish conservation in the targets of Teashirt transcription factors in mouse embryonic kidney...
  40. ncbi Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney
    Dinender Kumar
    Division of Nephrology, Department of Medicine, The Ottawa Hospital, Ottawa, Ont, Canada
    Nephron Exp Nephrol 96:e77-88. 2004
    ..We studied the extent of apoptosis in streptozotocin (STZ) induced diabetic nephropathy in the rat and the effects of insulin and type 1 (AT1) or type 2 (AT2) Ang II receptor blockade with losartan or PD123319, respectively...
  41. pmc Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation
    Jin Wu
    Division of Experimental Diabetes and Aging, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Pathol 176:2163-76. 2010
    ..The expression of tumor-necrosis factor-alpha in 22-month-old diabetic kidneys may play a role in inflammation, ER stress, and apoptosis. Thus, diabetes may accelerate the underlying kidney aging process present in old mice...
  42. ncbi Active Ca(2+) reabsorption in the connecting tubule
    Sandor Boros
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Pflugers Arch 458:99-109. 2009
    ..In addition, an overview of the recently identified mechanisms governing this active Ca(2+) transport through the DCT2/CNT epithelial cells will be presented...
  43. ncbi Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis
    Claudio Bazzi
    Division of Nephrology and Dialysis and Biochemical Laboratory, San Carlo Borromeo Hospital, Milan, Italy
    Nephrol Dial Transplant 17:1890-6. 2002
    ..The second aim was to assess whether NAG excretion has a predictive value on functional outcome and response to therapy...
  44. ncbi Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells
    Zhou Yang
    Center of Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, China
    Am J Physiol Renal Physiol 299:F336-46. 2010
    ..Our findings highlight a need for carefully reevaluating our previous view on the pathological roles of hyperuricemia in the kidney and nephropathy induced by uric acid in clinical practice...
  45. ncbi Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage
    Perla D Maldonado
    Department of Biology, Universidad Nocional Autonoma de Mexico, Mexico D F, Mexico
    Free Radic Biol Med 35:317-24. 2003
    ..In conclusion, SAC ameliorates the GM-induced ARF by a mechanism related, at least in part, to its ability to decrease oxidative stress and to preserve antioxidant enzymes activity in renal cortex...
  46. pmc Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation
    Yanhua Zhao
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Diabetes 60:1907-16. 2011
    ..We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys...
  47. ncbi Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis
    Inga Sörensen
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Kidney Int 80:1035-44. 2011
    ..Thus, our study suggests that fibrinogen promotes renal fibrosis by triggering resident fibroblast proliferation...
  48. pmc Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury
    Hao Bao
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Kidney Int 81:662-73. 2012
    ..Hence, inhibition of GSK3β ameliorates NSAID-induced acute kidney injury by induction of renal cortical COX-2 and direct inhibition of the mitochondrial permeability transition...
  49. pmc Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:497-506. 2012
    ..Because similar compounds seem to be safe in humans, mitochondrially targeted antioxidants may represent a novel therapeutic approach against cisplatin nephrotoxicity...
  50. pmc Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress
    Qing Yuan
    Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
    PLoS ONE 6:e25811. 2011
    ..The purpose of current study is to demonstrate the effect of antecedent ethanol exposure on IR-induced renal injury by modulation of oxidative stress...
  51. pmc An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice
    Milena Traykova-Brauch
    Department of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Med 14:979-84. 2008
    ..These experiments establish Pax8-rtTA mice as a powerful tool for modeling renal diseases in transgenic mice...
  52. ncbi Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
    Stefano Gatti
    Center for Surgical Research, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    Nephrol Dial Transplant 26:1474-83. 2011
    ..We recently demonstrated that microvesicles (MVs) released from MSCs may account for this paracrine mechanism by a horizontal transfer of messenger RNA and microRNA...
  53. ncbi Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice
    Fangming Lin
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Mail Code 9063, Dallas, TX 75390 9063, USA
    J Am Soc Nephrol 14:1188-99. 2003
    ..This is the first report to show that HSC can differentiate into renal tubular cells after I/R injury. Because of their availability, HSC may be useful for cell replacement therapy of acute renal failure...
  54. pmc Loss of oriented cell division does not initiate cyst formation
    Saori Nishio
    Section of Nephrology, Yale University School of Medicine, P O Box 208029, 333 Cedar Street, New Haven, CT 06520 8029, USA
    J Am Soc Nephrol 21:295-302. 2010
    ..In conclusion, loss of oriented cell division is a feature of Pkhd1 mutation and cyst formation, but it is neither sufficient to produce kidney cysts nor required to initiate cyst formation after mutation in Pkd1 or Pkd2...
  55. ncbi Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo
    Intern Med 43:9-17. 2004
    ..This induces chronic hypoxia in this compartment, rendering a vicious cycle. Development of novel therapeutic approaches against these final common pathways will enable us to target any types of renal disease...
  56. ncbi Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
    Srinivasan Kalayarasan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
    Eur J Pharmacol 606:162-71. 2009
    ..To conclude, DAS enhances antioxidants and suppresses inflammatory cytokines through the activation of Nrf2, thereby protecting the cell against oxidative stress induced by gentamicin...
  57. pmc Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    Jeremy S Duffield
    Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 115:1743-55. 2005
    ..It is likely that intrinsic tubular cell proliferation accounts for functionally significant replenishment of the tubular epithelium after ischemia...
  58. ncbi Recent advances in the pathophysiology of ischemic acute renal failure
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, and the Harvard MIT, Division of Health Sciences and Technology, Charlestown, Massachusetts, USA
    J Am Soc Nephrol 14:2199-210. 2003
  59. ncbi Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
    I A Drummond
    Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
    Development 125:4655-67. 1998
    ..These studies reveal the similarity of normal pronephric development to kidney organogenesis in all vertebrates and allow for a genetic dissection of genes needed to establish the earliest renal function...
  60. pmc Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling
    Xiaoyue Tan
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 19:1741-52. 2008
    ..These results suggest that paricalcitol inhibits renal inflammatory infiltration and RANTES expression by promoting VDR-mediated sequestration of NF-kappaB signaling...
  61. ncbi A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis
    Michelle P Winn
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 308:1801-4. 2005
    ..Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease...
  62. ncbi Differential expression and function of cadherin-6 during renal epithelium development
    E A Cho
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Development 125:803-12. 1998
    ..These data suggest that cadherin-6 function is required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium...
  63. ncbi Apoptosis in the kidneys of patients with type II diabetic nephropathy
    D Verzola
    Nephrology Division, Department of Internal Medicine, Genoa University, Genoa, Italy
    Kidney Int 72:1262-72. 2007
    ..Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients...
  64. pmc Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ
    Balu K Chacko
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Biochem J 432:9-19. 2010
    ..They also highlight a relatively unexplored aspect of mitochondrial ROS signalling in the control of fibrosis...
  65. ncbi Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney
    Shinji Kitamura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    FASEB J 19:1789-97. 2005
    ..These results suggest rKS56 cells possess character such as self-renewal, multi-plasticity and capability of tissue repair. rKS56 may possibly contribute to the future development of cell therapy for renal regeneration...
  66. ncbi Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Lab Invest 85:1292-307. 2005
    ..Collectively, these findings demonstrate a renoprotective role of HIF through angiogenesis and provide a rationale for therapeutic approaches to target HIF for activation...
  67. ncbi Autosomal dominant polycystic kidney disease
    Vicente E Torres
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet 369:1287-301. 2007
    ....
  68. ncbi Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein
    Maciej Lech
    Medizinische Poliklinik University of Munich, Munich, Germany
    J Immunol 183:4109-18. 2009
    ..Thus, loss of function mutations in the SIGIRR gene predispose to acute renal failure because SIGIRR prevents overshooting tissue injury by suppressing the postischemic activation of intrarenal myeloid cells...
  69. pmc Proteinuria and hyperglycemia induce endoplasmic reticulum stress
    Maja T Lindenmeyer
    Nephrology Center, Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 19:2225-36. 2008
    ..Although this may protect the cells from ER stress, persistence of hyperglycemia and proteinuria may eventually lead to apoptosis...
  70. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
  71. ncbi Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury
    J Deng
    Renal Diagnostics and Therapeutics Unit, NIDDK, and Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892-1268, USA
    Kidney Int 60:2118-28. 2001
    ..CONCLUSIONS: IL-10 protects against renal ischemic and cisplatin-induced injury. IL-10 may act, in part, by inhibiting the maladaptive activation of genes that cause leukocyte activation and adhesion, and induction of iNOS...
  72. ncbi TGF-beta1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction
    Meeyul Hwang
    Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea
    Exp Mol Pathol 81:48-54. 2006
    ..This work would provide a valuable tool to prevent tubulointerstitial fibrosis using RNA interference strategy...
  73. pmc The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice
    Volha Ninichuk
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Am J Pathol 170:1267-76. 2007
    ..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy...
  74. pmc Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants
    Selim Terhzaz
    Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Physiol Genomics 41:33-41. 2010
    ..The physiological impacts of defective ANT expression are thus widespread and diverse...
  75. ncbi Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia
    J G Hoenderop
    Department of Cell Physiology, Institute of Cellular Signaling, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 274:8375-8. 1999
    ..Thus, ECaC has the expected properties for being the gatekeeper of 1,25-dihydroxyvitamin D3-dependent active transepithelial Ca2+ transport...
  76. ncbi Inflammatory cytokines and lipopolysaccharide induce Fas-mediated apoptosis in renal tubular cells
    Sang Kyung Jo
    Department of Internal Medicine, Korea University Hospital, Anam dong 5Ka, 136 705 Sungbuk ku, Seoul, Korea
    Nephron 91:406-15. 2002
    ....
  77. ncbi Autophagy protects renal tubular cells against cyclosporine toxicity
    Nicolas Pallet
    INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, Paris, France
    Autophagy 4:783-91. 2008
    ..Taken together, these results demonstrate that CsA, through ER stress induction, activates autophagy as a protection against cell death...
  78. ncbi Renal localization and function of the tight junction protein, claudin-19
    Susanne Angelow
    Department of Medicine, Division of Nephrology, Univesity of Southern California Keck School of Medicine, 2025 Zonal Ave, RMR 406, Los Angeles, CA 90033, USA
    Am J Physiol Renal Physiol 293:F166-77. 2007
    ..This would be consistent with its physiological role to electrically seal myelinated peripheral neurons. The normal role of claudin-19 in renal tubule function remains to be determined...
  79. pmc Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury
    Ling Li
    Dept of Pediatrics, Columbia Univ College of Physicians and Surgeons, 630 West 168th St, New York, NY 10032, USA
    Am J Physiol Renal Physiol 302:F9-F19. 2012
    ..Our study indicates that hematopoietic stem and progenitor cells can be converted to a large number of renal-like cells within a short period for potential treatment of acute kidney injury...
  80. ncbi Differential gene expression following early renal ischemia/reperfusion
    Suroj Supavekin
    Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    Kidney Int 63:1714-24. 2003
    ..The purpose of this study was to identify apoptosis-related genes that are differentially expressed in the early periods following renal ischemia...
  81. pmc Molecular clock is involved in predictive circadian adjustment of renal function
    Annie Mercier Zuber
    Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 106:16523-8. 2009
    ..Collectively, this study uncovers a major role of molecular clock in renal function...
  82. ncbi Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney
    Akito Maeshima
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    J Am Soc Nephrol 17:188-98. 2006
    ..Collectively, these findings suggest that LRTC are an adult kidney tubular cell population that shows phenotypic plasticity, tubulogenic capacity, and integration capability into the developing kidney...
  83. ncbi Primary IgA nephropathy: new insights into pathogenesis
    Jonathan Barratt
    The John Walls Renal Unit, Leicester General Hospital and Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Semin Nephrol 31:349-60. 2011
    ..Genetic factors are likely to influence many facets of pathogenesis both in primary and familial IgA nephropathy, however, to date work in this area has failed to identify consistent candidate genes...
  84. ncbi Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity
    Arantxa Ortega
    Laboratorio de Metabolismo Mineral y Oseo, Pathology Department, Fundación Jiménez and Universidad Autónoma de Madrid, Spain
    J Am Soc Nephrol 17:1594-603. 2006
    ..Our findings indicate that this peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor in the FA-damaged kidney...
  85. ncbi Kidney injury molecule-1 in renal disease
    Femke Waanders
    Kidney Centre, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Pathol 220:7-16. 2010
    ..Finally, the potential of KIM-1 as biomarker of renal damage, as a predictor of renal function decline and its perspectives for monitoring therapy response, are discussed...
  86. pmc Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
    Robert Koesters
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Am J Pathol 177:632-43. 2010
    ..In conclusion, overexpression of TGF-beta1 in renal tubules in vivo induces interstitial proliferation, tubular autophagy, and fibrosis, but not epithelial-to-mesenchymal transition...
  87. pmc Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours
    Kyra Campbell
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, 08028 Barcelona, Spain
    Mech Dev 127:345-57. 2010
    ..We suggest that the formation of zonula adherens junctions between new cell neighbours establishes their apico-basal positions and stabilises them in the epithelium...
  88. ncbi A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract
    Xinli Shao
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 13:1824-36. 2002
    ..Transgenic mice that express GFP in the mesonephros, metanephros, ureteric bud, and sex ducts may be useful for cell lineage studies...
  89. pmc p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway
    Lin Sun
    Dept of Nephrology, 2nd Xiangya Hospital, Central South Univ, No 139 Renmin Middle Rd, Changsha, Hunan 410011
    Am J Physiol Renal Physiol 299:F1014-25. 2010
    ..These data suggest that p66Shc mediates HG- and ANG II-induced mitochondrial dysfunctions via PKC-β and Pin1-dependent pathways in renal tubular cells...
  90. ncbi Expression of the chemokine receptor CCR1 in human renal allografts
    Verena Mayer
    Medizinische Poliklinik Innenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Nephrol Dial Transplant 22:1720-9. 2007
    ..CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts...
  91. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
    ..Our results support the hypothesis that CD151 plays a key role in strengthening alpha3beta1-mediated adhesion in podocytes...
  92. ncbi Activation of tubular epithelial cells in diabetic nephropathy
    Michael Morcos
    Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 51:3532-44. 2002
    ....
  93. ncbi What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)?
    Charles L Edelstein
    Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Cell Cycle 4:1550-4. 2005
    ..Thus, there is evidence that both epithelial cell apoptosis and proliferation are dysregulated in ADPKD and may represent a general mechanism for cyst growth...
  94. pmc Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Virol 85:9811-23. 2011
    ..The finding that different renal cell types are susceptible to hantaviral infection and the fact that infection results in the breakdown of cell-to-cell contacts provide useful insights in hantaviral pathogenesis...
  95. ncbi Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
    Junwei Yang
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 13:2464-77. 2002
    ..These findings may provide the basis for designing future therapeutic regimens for blocking progressive renal fibrosis in patients...
  96. pmc Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice
    Sayuri Suzuki
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Japan
    Am J Pathol 171:473-83. 2007
    ..These findings suggest that p27 accumulation, which results from SCF-Skp2 ubiquitin ligase deficiency in Skp2(-/-) mice, is involved in the amelioration of renal damage induced by obstructive nephropathy...
  97. pmc Adult human CD133/1(+) kidney cells isolated from papilla integrate into developing kidney tubules
    Heather H Ward
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Biochim Biophys Acta 1812:1344-57. 2011
    ..culture demonstrated that CD133/1(+) progenitors from the papilla and cortex became integrated into developing kidney tubules. Tubular epithelia did not participate in tubulogenesis...
  98. ncbi Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney
    Yan Ge
    Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Lab Invest 91:85-96. 2011
    ..Extended examinations of these KO under diseased conditions are merited to understand the role of GSK3β in renal pathophysiology...
  99. pmc Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis
    Yingjian Li
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 20:1907-18. 2009
    ..These findings suggest that increased ILK activity mediates EMT and the progression of renal fibrosis. Pharmacologic inhibition of ILK signaling may hold therapeutic potential for fibrotic kidney diseases...
  100. pmc Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Free Radic Biol Med 49:1273-82. 2010
    ..RW injury of renal tubular cells and suggest that therapeutic inhibition of these pathways may protect the donor kidney...
  101. pmc Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy
    Susan P Bothwell
    University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Am Soc Nephrol 22:443-8. 2011
    ..Thus, we created an animal model for OCRL and Dent Disease 2 tubulopathy by humanizing a modifier paralog in mice already carrying the mutant disease gene...

Research Grants63

  1. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..important for multiple translational applications, including 1) incorporation into 3D structures to construct kidney tubules, as a first step to bioengineering patient-specific kidney tissue, 2) incorporation into renal assist devices ..
  2. Regulation of ENaC Transcription
    Bruce C Kone; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Sodium reabsorption by the epithelial sodium channel in the kidney tubules is an essential mechanism involved in the regulation of sodium balance, fluid volume, and blood pressure...
  3. SGK Regulation of Epithelial Sodium Transport
    David Pearce; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hormone-regulated Na+ transport in the kidney tubules is critical to the control of blood pressure and other vital processes in health and disease...
  4. Role of Meprins in Ischemia Reperfusion induced renal injury
    Elimelda Moige Ongeri; Fiscal Year: 2013
    ..Meprins, metalloproteases that are abundantly expressed in the brush border membranes (BBM) of proximal kidney tubules, have been implicated in the pathology of IR...
  5. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ..including drug metabolism, transport, and regulatory pathways that directly influence the exposure of kidney tubules to cisplatin...
  6. Biologic Effects of Cdk2 Substrate Phosphorylation on Acute Kidney Injury
    Peter M Price; Fiscal Year: 2013
    ..Our recently developed transgenic mice in which Cdk2 inhibitors can be induced in kidney tubules confirmed this hypothesis for cisplatin nephrotoxicity...
  7. Cell-Matrix Interactions in Epithelial Polarization
    Karl S Matlin; Fiscal Year: 2010
    Epithelial cells form the parenchyma of the kidney and most other solid organs. In kidney tubules they are responsible for absorptive and secretory events that recover fluid and ions from filtered blood and discharge waste products into ..
  8. Role of Collecting Duct Chloride Transporters in Volume Regulation
    Manoocher Soleimani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The balance between salt excretion and absorption in the kidney tubules is a major determinant of vascular volume homeostasis and systemic blood pressure...
  9. Novel role of AQP2 in cell migration and kidney tubular injury and repair
    HUA A LU; Fiscal Year: 2013
    ..patients with polycystic kidney diseases with polyuria and coexisting structural and functional defects of the kidney tubules. Therefore, we hypothesize that AQP2 is important for maintaining the structural and functional integrity of ..
  10. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    PROJECT SUMMARY / ABSTRACT Small intestine and kidney tubules play essential roles in the absorption and homeostatic balance of salt and carbohydrates...
  11. Functional characterization of a novel adult renal progenitor cell population
    TROY D CAMARATA; Fiscal Year: 2011
    ..cells in normal adult mouse kidney, 2) Determine the ability of Flk+/Sca1+ cells to incorporate and repair kidney tubules after ischemic or toxic injury, and 3) Establish a role of Sca1 function in renal tubule homeostasis and ..
  12. The Role of Planar Cell Polarity Signals in Shaping Kidney Tubules
    RACHEL KATHERINE MILLER; Fiscal Year: 2013
    ..In sum, we will enhance our understanding of kidney morphogenesis, which is likely to be relevant to obtaining insights on later pathologies that arise in humans. ..
  13. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2013
    ..proteomic analysis of 10;characterizing accessory proteins involved in trafficking pathways in different kidney tubules;generating new knockout and transgenic mice that open new avenues for understanding IC development and V-..
  14. Gpx3 Targeting and Extracellular Oxidative Stress
    Raymond F Burk; Fiscal Year: 2012
    ..methods to detect Gpx3 and have used them to show that Gpx3 binds specifically to the basement membranes of kidney tubules, small intestine, colon, and other absorptive epithelia...
  15. THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
    Alan M Weinstein; Fiscal Year: 2013
    ..of this project is mathematical modeling and computer simulation of fluid and electrolyte disorders in kidney tubules. To date, this project has formulated models of glomerulus, proximal convoluted tubule, and all segments from ..
  16. Interactions between the stroma and progenitor cells during kidney development
    THOMAS JOSEPH CARROLL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kidney tubules arise from a population of multi-potent progenitor cells located within the metanephric mesenchyme...
  17. Kidney molecular atlas project
    Andrew P McMahon; Fiscal Year: 2010
    ..3: We will perform transcriptional array analysis of renal tubule deficient mouse kidneys and micro-dissected kidney tubules to identify, and subsequently map the expression of tubule specific genes...
  18. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
    ..Studies will be conducted with hepatocytes, perfused rat heart, kidney tubules, adipocytes, microsomes, and a partially purified enzyme system...
  19. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    ..number of functional, toxicological, and pharmacological similarities between inner ear cells and cells of the kidney tubules. To exploit these similarities, we have developed cloned sub-lines of currently-available kidney cell lines to ..
  20. Delineating a role for non-canonical wnt signaling in PKD
    THOMAS JOSEPH CARROLL; Fiscal Year: 2013
    ..we hypothesize that oriented cell movement is required to establish and maintain the proper diameter of kidney tubules. In this proposal, we will use a combination of genetic engineering as well as live cell imaging to test these ..
  21. Urea Transport Physiology Studies in Knockout Mice
    Baoxue Yang; Fiscal Year: 2005
    Urea transporters (UTs) are expressed in kidney tubules and microvessels, and in extrarenal tissues...
  22. Specification of the Avian Intermediate Mesoderm
    THOMAS SCHULTHEISS; Fiscal Year: 2005
    ..has been made in understanding later stages of kidney development, during which the IM differentiates into kidney tubules, very little is known about the critical, early stages in which the IM itself is generated...
  23. Kidney development and cystogenesis in Medaka
    Tomoko Obara; Fiscal Year: 2005
    ..is a hereditary disease occurring at a frequency of 1:1000 in humans and characterized by cyst formation in kidney tubules, deregulated fluid transport and alteration of extracellular adhesion...
  24. Decoupling of Principal Renal Autoregulatory Mechanisms
    Ki Chon; Fiscal Year: 2005
    ..Highly regular blood pressure fluctuations in the kidney tubules in normotensive rats are replaced by highly irregular pressure fluctuations in hypertensive rats...
  25. IN VITRO KIDNEY CELL CULTURE FOR NEPHROTOXIN ASSAYS
    FREDERICK CAHN; Fiscal Year: 1992
    Renal ischemia and poisoning of the kidney tubules by toxic agents are major causes of tubular necrosis and acute renal failure...
  26. ISOLATED RENAL TUBULE PHYSIOLOGY OF ORGANIC IONS
    JAMES IRISH; Fiscal Year: 1980
    ..The proposed experiments will make use of rabbit kidney tubules to investigate: 1) prostaglandin transport characteristics along the nephron; 2) the location and factors that ..
  27. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  28. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  29. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  30. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  31. Iron and Vitamin E in Childhood HIV-Associated Renal Disease
    Patricio Ray; Fiscal Year: 2006
    ..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. [unreadable] [unreadable]..
  32. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ....
  33. TISSUE-CRYSTAL INTERACTION CA OXALATE NEPHROLITHIASIS
    Saeed Khan; Fiscal Year: 2003
    ..We can follow various events of nephrolithiasis in the animal model and cats explore the outcome of renal epithelial cell exposure to oxalate and calcium oxalate crystals in the cell cultures. ..
  34. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  35. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  36. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  37. ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEY
    Gerhard Giebisch; Fiscal Year: 2003
    ..Patch-clamp and whole-cell current measurements will be carried out in native tubules and in an oocyte expression system, and tubule perfusion studies in ROMK knock-out mice. ..
  38. CELLULAR PATHOPHYSIOLOGY OF ACUTE RENAL FAILURE
    Joel Weinberg; Fiscal Year: 2007
    ..abstract_text> ..
  39. Epithelial Na channel (ENaC) polymorphisms in hyptertention
    James Stockand; Fiscal Year: 2007
    ..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
  40. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  41. Decoupling Dynamics of the Autonomic Nervous System
    Ki Chon; Fiscal Year: 2005
    ..abstract_text> ..
  42. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2008
    ..abstract_text> ..
  43. PREVENTION OF GRAFT FAILURE TO DIETARY N-3 FATTY ACIDS
    James Tumlin; Fiscal Year: 2002
    ..Secondary outcomes to be compared are molecular markers for thrombosis, inflammation, and vascular risk factors. ..
  44. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  45. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  46. Developing Predictive Methods for Sudden Cardiac Death
    Ki Chon; Fiscal Year: 2002
    ..It is intended that the algorithm will be applicable to other physiological systems and may become a widely accepted noninvasive clinical alternative. ..
  47. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 2002
    ..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
  48. CELLULAR PHENOTYPES OF SALT SENSITIVITY
    Abraham Aviv; Fiscal Year: 2001
    ..The investigators state that the results of the study will generate a novel perspective about phenotypes of salt sensitivity and, an insight into the cardiovascular effects of high salt in humans. ..
  49. Complement and Ischemic Acute Renal Failure
    JOSHUA THURMAN; Fiscal Year: 2007
    ..The purpose of these studies is to ameliorate ischemic ARF by blocking these pathogenic events, and to develop strategies for decreasing the morbidity and mortality associated with ischemic ARF in humans. ..
  50. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. FAT10 a candidate gene for epithelial apoptosis in HIV-associated nephropathy
    Michael Ross; Fiscal Year: 2007
    ..These studies will advance our understanding of HIVAN pathogenesis and may yield a novel therapeutic target for the treatment of HIVAN and other renal diseases. [unreadable] [unreadable]..
  52. Mathematical Model of Vascular and Tubular Transport in the Rat Outer Medulla
    AURELIE EDWARDS; Fiscal Year: 2008
    ..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
  53. Renin activation in early diabetes
    Janos Peti Peterdi; Fiscal Year: 2009
    ..These studies should yield clinically important information that can be used to develop new drugs and therapeutic approaches for the better treatment of diabetic complications in the kidney as well as high blood pressure. ..
  54. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2008
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  55. MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEM
    Janos Peti Peterdi; Fiscal Year: 2008
    ..This multi-photon core is also critically needed for the USC Diabetes Research Center and the Clinical and Translational Science Institute, both being established pending PHS grants. [unreadable] [unreadable] [unreadable]..
  56. Cell Signaling in Developing Epithelia
    Gregory R Dressler; Fiscal Year: 2010
    ..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..
  57. Complement Activation and Renal Ischemia/Reperfusion Injury
    JOSHUA THURMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. Renal Function Derangements in Hypertension
    LUIS GABRIEL NAVAR; Fiscal Year: 2010
    ..The results obtained will further enhance our understanding of the important role of the intrarenal/intratubular/ interstitial renin angiotensin system in the pathophysiology of Ang II dependent hypertension. ..
  59. Epithelial gene expression in HIV-associated nephropathy
    Michael Ross; Fiscal Year: 2006
    ..It is also possible that genes implicated in the pathogenesis of HIVAN maybe important factors contributing to the marked predisposition of African-Americans to nearly all causes of renal failure. ..
  60. REGULATION OF RENAL HEMODYNAMICS
    LUIS NAVAR; Fiscal Year: 2006
    ..The results will provide an improved understanding of how these intrarenal paracrine factors interact to produce a coordinate regulation of renal microvascular hemodynamics. ..
  61. MATHEMATICAL MODELS OF RENAL DYNAMICS
    HAROLD LAYTON; Fiscal Year: 2009
    ..abstract_text> ..