specific pathogen free organisms

Summary

Summary: Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.

Top Publications

  1. ncbi Pathogenesis of feline enteric coronavirus infection
    Niels C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95694, USA
    J Feline Med Surg 10:529-41. 2008
  2. ncbi Sites of feline coronavirus persistence in healthy cats
    Anja Kipar
    Veterinary Pathology, School of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    J Gen Virol 91:1698-707. 2010
  3. ncbi Interactions between commensal intestinal bacteria and the immune system
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Rev Immunol 4:478-85. 2004
  4. ncbi Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection
    Ashraful Haque
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    J Infect Dis 193:370-9. 2006
  5. ncbi Experimental pathogenesis for chickens, turkeys, and pigeons of exotic Newcastle disease virus from an outbreak in California during 2002-2003
    N Wakamatsu
    Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D W Brooks Drive, Athens, GA 30602 7388, USA
    Vet Pathol 43:925-33. 2006
  6. ncbi Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood
    Agnès Jamin
    French Agency for Food Safety AFSSA, Poultry and Swine Research Laboratory, Swine Virology Immunology Unit, Ploufragan, France
    Vet Immunol Immunopathol 114:224-37. 2006
  7. ncbi Detection of mixed infections with "Candidatus Mycoplasma haemominutum" and Mycoplasma haemofelis using real-time TaqMan polymerase chain reaction
    Jane E Sykes
    Department of Medicine and Epidemiology, 2108 Tupper Hall, University of California, Davis, CA 95616, USA
    J Vet Diagn Invest 19:250-5. 2007
  8. ncbi Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme
    A L Sesink
    Wageningen Centre for Food Sciences, Netherlands Institute for Dairy Research Food Research, Ede
    Cancer Res 59:5704-9. 1999
  9. ncbi Lymphocyte proliferation response during Eimeria tenella infection assessed by a new, reliable, nonradioactive colorimetric assay
    Tadashi Miyamoto
    Parasite Biology, Epidemiology, and Systematics Laboratory, Animal and Natural Resources Institute, USDA, ARS, Beltsville, MD 20705, USA
    Avian Dis 46:10-6. 2002
  10. ncbi Adjuvant effects of IL-1beta, IL-2, IL-8, IL-15, IFN-alpha, IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina
    W Min
    Parasite Biology, Epidemiology, Systematics Laboratory, Animal and Natural Resources Institute, BARC-East, Building 1040, US Department of Agriculture, Beltsville, MD 20705, USA
    Vaccine 20:267-74. 2001

Detail Information

Publications254 found, 100 shown here

  1. ncbi Pathogenesis of feline enteric coronavirus infection
    Niels C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95694, USA
    J Feline Med Surg 10:529-41. 2008
    ..Pregnancy, parturition and lactation had no influence on fecal shedding by queens. Methylprednisolone acetate treatment did not induce non-shedders to shed and shedders to increase shedding...
  2. ncbi Sites of feline coronavirus persistence in healthy cats
    Anja Kipar
    Veterinary Pathology, School of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    J Gen Virol 91:1698-707. 2010
    ..These might represent additional sources for recurrent viraemia...
  3. ncbi Interactions between commensal intestinal bacteria and the immune system
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Rev Immunol 4:478-85. 2004
  4. ncbi Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection
    Ashraful Haque
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    J Infect Dis 193:370-9. 2006
    ..pseudomallei-specific T cells, in particular CD4(+) T cells, are important for host resistance...
  5. ncbi Experimental pathogenesis for chickens, turkeys, and pigeons of exotic Newcastle disease virus from an outbreak in California during 2002-2003
    N Wakamatsu
    Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D W Brooks Drive, Athens, GA 30602 7388, USA
    Vet Pathol 43:925-33. 2006
    ..Additionally, we have evidence of CA END virus subclinical infections that suggest pigeons could be subclinical carriers of other virulent NDV...
  6. ncbi Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood
    Agnès Jamin
    French Agency for Food Safety AFSSA, Poultry and Swine Research Laboratory, Swine Virology Immunology Unit, Ploufragan, France
    Vet Immunol Immunopathol 114:224-37. 2006
    ..Altogether, these data complete knowledge on porcine immune system cells and will be a useful tool for further in vivo studies on porcine DC role in peripheral tolerance induction and in immune responses to pathogens...
  7. ncbi Detection of mixed infections with "Candidatus Mycoplasma haemominutum" and Mycoplasma haemofelis using real-time TaqMan polymerase chain reaction
    Jane E Sykes
    Department of Medicine and Epidemiology, 2108 Tupper Hall, University of California, Davis, CA 95616, USA
    J Vet Diagn Invest 19:250-5. 2007
    ..The use of multiple separate real-time PCR assays rather than cPCR alone should thus be considered for epidemiologic studies of hemoplasmosis in cats...
  8. ncbi Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme
    A L Sesink
    Wageningen Centre for Food Sciences, Netherlands Institute for Dairy Research Food Research, Ede
    Cancer Res 59:5704-9. 1999
    ..This suggests that, in heme-fed rats, colonic mucosa is damaged by the intestinal contents. This results in a compensatory hyperproliferation of the epithelium, which supposedly increases the risk for colon cancer...
  9. ncbi Lymphocyte proliferation response during Eimeria tenella infection assessed by a new, reliable, nonradioactive colorimetric assay
    Tadashi Miyamoto
    Parasite Biology, Epidemiology, and Systematics Laboratory, Animal and Natural Resources Institute, USDA, ARS, Beltsville, MD 20705, USA
    Avian Dis 46:10-6. 2002
    ..The WST-8 assay is fast, simple, and more reproducible and sensitive than the MTT assay. This study demonstrates the effectiveness of the WST-8 assay to assess cell-mediated immune response of chickens in normal and disease states...
  10. ncbi Adjuvant effects of IL-1beta, IL-2, IL-8, IL-15, IFN-alpha, IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina
    W Min
    Parasite Biology, Epidemiology, Systematics Laboratory, Animal and Natural Resources Institute, BARC-East, Building 1040, US Department of Agriculture, Beltsville, MD 20705, USA
    Vaccine 20:267-74. 2001
    ..These results indicate that the type and the dose of cytokine genes injected into chickens influence the quality of the local immune response to DNA vaccination against coccidiosis...
  11. ncbi Comparative immunopathogenesis of mild, intermediate, and virulent strains of classic infectious bursal disease virus
    Silke Rautenschlein
    Klinik fur Geflugel, Tierarztliche Hochschule Hannover, Bunteweg 17, 30559 Hannover, Germany
    Avian Dis 47:66-78. 2003
    ..These results suggested that the local T cell events in the bursa alone may not be indicative of a rapid and protective immune response...
  12. ncbi Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death
    Karine Oumouna-Benachour
    Louisiana State University Health Sciences Center, Department of Pharmacology, 1901 Perdido St, New Orleans, LA 70112, USA
    Circulation 115:2442-50. 2007
    ..We hypothesized that PARP may play an important role in atherogenesis and that its inhibition may attenuate atherosclerotic plaque development in an experimental model of atherosclerosis...
  13. pmc Detection of vvIBDV in vaccinated SPF chickens
    S Kabell
    Danish Institute for Food and Veterinary Research, Hangøvej 2, DK 8200 Aarhus N Denmark
    Acta Vet Scand 46:219-27. 2005
    ..The results indicate a possibility of replication of vvlBDV in vaccinated chickens...
  14. pmc Voriconazole inhibits fungal growth without impairing antigen presentation or T-cell activation
    Heather L Van Epps
    Laboratory of Antimicrobial Immunity, Immunology Program, and Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Antimicrob Agents Chemother 47:1818-23. 2003
    ..Thus, voriconazole appears to be a promising agent for use in in vitro studies of Aspergillus-specific T lymphocytes in animal models of IA...
  15. ncbi Resistance to intestinal coccidiosis following DNA immunization with the cloned 3-1E Eimeria gene plus IL-2, IL-15, and IFN-gamma
    Hyun S Lillehoj
    Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
    Avian Dis 49:112-7. 2005
    ..Taken together, these results indicate that in ovo immunization with a recombinant Eimeria gene in conjunction with cytokine adjuvants stimulates protective intestinal immunity against coccidiosis...
  16. ncbi Continuing evolution of H9 influenza viruses in Korean poultry
    Youn Jeong Lee
    Avian Disease Division, National Veterinary Research and Quarantine Service, 480 Anyang, Anyang City, 430 824, Korea
    Virology 359:313-23. 2007
    ..The pathogenicity of the early isolates altered due to antigenic drift and reassortment, leading to H9 avian influenza viruses in Korea that potentially can expand their host range to mammalians...
  17. ncbi Priming with DNA vaccine and boosting with killed vaccine conferring protection of chickens against infectious bursal disease
    Ming Kun Hsieh
    Department of Comparative Pathobiology, School of Veterinary Medicine, 406 S University Street, Purdue University, West Lafayette, IN 47907, USA
    Vaccine 25:5417-27. 2007
    ....
  18. pmc Effects of DDA, CpG-ODN, and plasmid-encoded chicken IFN-gamma on protective immunity by a DNA vaccine against IBDV in chickens
    Ha Jung Roh
    School of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 200 701, Korea
    J Vet Sci 7:361-8. 2006
    ..These results suggest that DDA actually compromises the protection against the IBDV by DNA vaccine, and CpG-ODN and IFN-gamma had no significant effect...
  19. ncbi Protective immunity against infectious bursal disease virus in chickens in the absence of virus-specific antibodies
    Hung Yueh Yeh
    Department of Veterinary Pathobiology, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Vet Immunol Immunopathol 89:149-58. 2002
    ..We concluded that under normal conditions, IBDV induces a protective antibody response, however, in the absence of antibody, CMI alone is adequate in protecting birds against virulent IBDV...
  20. ncbi The role of T cells in protection by an inactivated infectious bursal disease virus vaccine
    Silke Rautenschlein
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Immunol Immunopathol 89:159-67. 2002
    ..We propose that the inability of iIBDV to protect TxCsA chickens was due to compromised T cell immunity, functional T helper cells and most likely also cytotoxic T cells are needed in iIBDV vaccine protection...
  21. ncbi Efficacy and safety of an infectious bursal disease virus intermediate vaccine in ovo
    M Coletti
    Dipartimento di Scienze Biopatologiche Veterinarie, , Italy
    Avian Dis 45:1036-43. 2001
    ..In commercial chickens, immunoresponse to NDV vaccination was not influenced by in ovo vaccination...
  22. pmc Dietary fructo-oligosaccharides and lactulose inhibit intestinal colonisation but stimulate translocation of salmonella in rats
    I M J Bovee-Oudenhoven
    Wageningen Centre for Food Sciences, Ede, The Netherlands
    Gut 52:1572-8. 2003
    ..However, compelling scientific evidence from in vivo infection studies is lacking. Therefore, we studied the effect of several non-digestible carbohydrates on the resistance of rats to Salmonella enteritidis infection...
  23. ncbi Effect of preexisting FeLV infection or FeLV and feline immunodeficiency virus coinfection on pathogenicity of the small variant of Haemobartonella felis in cats
    Jeanne W George
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Vet Res 63:1172-8. 2002
    ..To investigate the effects of preexisting FeLV infection or FeLV and feline immunodeficiency (FIV) coinfection on the pathogenicity of the small variant of Haemobartonella felis (Hfsm, California variant) in cats...
  24. ncbi Control of homeostasis of CD8+ memory T cells by opposing cytokines
    C C Ku
    Howard Hughes Medical Institute, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Science 288:675-8. 2000
    ..This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2...
  25. ncbi Effect of chronic feline immunodeficiency infection, and efficacy of marbofloxacin treatment, on 'Candidatus Mycoplasma haemominutum' infection
    Severine Tasker
    School of Clinical Veterinary Science, University of Bristol, Langford, Bristol, BS40 5DU, United Kingdom
    Microbes Infect 8:653-61. 2006
    ..This study documents, for the first time, the infection kinetics and antibiotic responsiveness of 'Candidatus M. haemominutum' infection...
  26. ncbi High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats
    M Meli
    Clinical Laboratory, Faculty of Veterinary Medicine, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    J Feline Med Surg 6:69-81. 2004
    ..Pathological findings were restricted to generalized lymphatic hyperplasia. These findings demonstrate the presence of systemic FCoV infection with high viral loads in the absence of clinical and pathological signs...
  27. ncbi Feline leukaemia provirus load during the course of experimental infection and in naturally infected cats
    R Hofmann-Lehmann
    Clinical Laboratory, Department of Internal Veterinary Medicine, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland
    J Gen Virol 82:1589-96. 2001
    ..Detection of provirus carriers should contribute to further the control of FeLV. In addition, quantification of provirus loads will lead to a better understanding of FeLV pathogenesis and anti-retrovirus protective mechanisms...
  28. ncbi Inoculation of two genotypes of Hemobartonella felis (California and Ohio variants) to induce infection in cats and the response to treatment with azithromycin
    D S Westfall
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Am J Vet Res 62:687-91. 2001
    ....
  29. ncbi Natural feline coronavirus infection: differences in cytokine patterns in association with the outcome of infection
    Anja Kipar
    Institut für Veterinär Pathologie, Justus Liebig Universitat Giessen, Frankfurter Strasse 96, 35392 Giessen, Germany
    Vet Immunol Immunopathol 112:141-55. 2006
    ..Development of FIP, however, might be due to a lack of IL-12 which inhibits an effective cellular immune response and allows for monocyte/macrophage activation and the development of FIP...
  30. ncbi Serological survey for avian paramyxoviruses from wildfowl in aquatic habitats in Andalusia
    A Maldonado
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Cordoba, Spain
    J Wildl Dis 31:66-9. 1995
    ..By contrast, in non-aquatic species high antibody prevalences were detected only to PMV-2 (60%), particularly in sparrows (68%), while antibody prevalences to other PMV's were moderate or low...
  31. ncbi Comparative study on the pathogenicity and immunogenicity of wild bird isolates of avian paramyxovirus 2, 4, and 6 in chickens
    Ashwini Warke
    Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USA
    Avian Pathol 37:429-34. 2008
    ..The replication of the virus in the birds was confirmed by isolation of the virus in embryonated eggs...
  32. ncbi Copy number polymorphism of endogenous feline leukemia virus-like sequences
    Ravi Tandon
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Mol Cell Probes 21:257-66. 2007
    ..The assays described herein are important prerequisites to quantify enFeLV loads and thus to investigate the influence of enFeLV loads on the course of FeLV infection...
  33. ncbi Cold agglutinins in cats with haemobartonellosis
    J C Zulty
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus 43210 1093
    J Am Vet Med Assoc 196:907-10. 1990
    ..These data indicate that cold agglutinins are associated with haemobartonellosis and suggest that immunologic responses to erythrocytic antigens have a role in the anemia...
  34. pmc Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
    Scott M Lieberman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:8384-8. 2003
    ..The human IGRP gene maps to a diabetes susceptibility locus, suggesting that IGRP also may be an antigen for pathogenic T cells in human type 1 diabetes and, thus, a new, potential target for diagnostic and therapeutic approaches...
  35. ncbi Classical swine fever virus induces activation of plasmacytoid and conventional dendritic cells in tonsil, blood, and spleen of infected pigs
    Agnès Jamin
    French Agency for Food Safety AFSSA, Poultry and Swine Research Laboratory, Swine Virology Immunology Unit, BP 53, 22440 Ploufragan, France
    Vet Res 39:7. 2008
    ....
  36. ncbi Protection against very virulent infectious bursal disease virus in chickens immunized with DNA vaccines
    Soo Joung Kim
    Department of Veterinary Medicine, Kangwon National University, Chunchon 200 701, Republic of Korea
    Vet Microbiol 101:39-51. 2004
    ....
  37. ncbi Detection of chicken anemia virus DNA in the thymus of naturally infected chicks in turkey
    H Yilmaz
    University of Istanbul, Veterinary Faculty, Department of Microbiology, Avcilar, Turkey
    Avian Dis 45:529-33. 2001
    ..Atrophy was noted in the thymus and in the bursa of Fabricius of positive chicks, and hemorrhages in the proventriculus of one positive chick were observed. This report describes the first detection of CAV DNA in chicks in Turkey...
  38. ncbi Shedding of feline leukemia virus RNA in saliva is a consistent feature in viremic cats
    M A Gomes-Keller
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland
    Vet Microbiol 112:11-21. 2006
    ....
  39. ncbi Depletion of CD4(+) and CD8(high+) T-cells before the onset of viraemia during classical swine fever
    A Summerfield
    Institute of Virology and Immunoprophylaxis, Sensemattstrasse 293, 3147, Mittelhausern, Switzerland
    Vet Immunol Immunopathol 78:3-19. 2001
    ..Furthermore, these characteristics offer an explanation for the retardation of the cellular and humoral immune response observed during classical swine fever...
  40. ncbi Cloning of a gene fragment encoding chicken complement component C3d with expression and immunogenicity of Newcastle disease virus F gene-C3d fusion protein
    Dong Liu
    College of Animal Science and Veterinary Medicine, Shandong Agriculture University, Tai an, People s Republic of China
    Avian Pathol 37:477-85. 2008
    ....
  41. ncbi The failure of oral tolerance induction is functionally coupled to the absence of T cells in Peyer's patches under germfree conditions
    Y Maeda
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Immunobiology 204:442-57. 2001
    ....
  42. ncbi Drop of egg production in chickens by experimental infection with an avian metapneumovirus strain PLE8T1 derived from swollen head syndrome and the application to evaluate vaccine
    Miki Sugiyama
    Tsukuba Laboratories, Merial Japan Limited, Ibaraki, Japan
    J Vet Med Sci 68:783-7. 2006
    ..It was suggested that this challenge system could be applied to evaluate the efficacy of aMPV vaccine...
  43. ncbi CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    A M Krieg
    Interdisciplinary Graduate Program in Immunology, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    J Immunol 161:2428-34. 1998
    ..These data support the hypothesis that CpG DNA motifs are a "danger signal" that activates protective innate immune defenses and may have therapeutic potential...
  44. ncbi Immune responses and pathogenesis in immunocompromised chickens in response to infection with the H9N2 low pathogenic avian influenza virus
    Ji Sun Kwon
    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Virus Res 133:187-94. 2008
    ..Our findings suggest that T-cell-mediated responses are important in influenza viral clearance and may help to explain in part the reasons for the increased mortality in chickens infected with H9N2 LPAI viruses in domestic poultry farms...
  45. ncbi Effect of various adjuvants on secondary immune response in chickens
    L A Hilgers
    Solvay Research and Technology, Applied Immunology, Brussels, Belgium
    Vet Immunol Immunopathol 66:159-71. 1998
    ..e. polyacrylate and DDA revealed only slight, beneficial effects. We concluded that the various types of adjuvants tested can stimulate secondary immune responses in primed animals but that W/O is superior...
  46. ncbi A full flora, but not monocolonization by Escherichia coli or lactobacilli, supports tolerogenic processing of a fed antigen
    C Rask
    Department of Clinical Bacteriology, Goteborg University, Goteborg, Sweden
    Scand J Immunol 61:529-35. 2005
    ..Conventional, but neither GF nor monocolonized mice showed upregulation of MHCII expression in the epithelium of small intestine. The results suggest that a complex intestinal microflora is needed to support oral tolerance development...
  47. pmc Childhood Helicobacter pylori infection in a murine model: maternal transmission and eradication by systemic immunization using bacterial antigen-aluminium hydroxide
    T Minoura
    Department of Paediatrics, Tohoku University School of Medicine, Sendai, Japan
    Clin Exp Immunol 134:32-7. 2003
    ..Our results indicate that our H. pylori vaccine provides not only protection, but also eradication of the already transmitted H. pylori...
  48. ncbi Induction of protective immunity in chickens immunised with plasmid DNA encoding infectious bursal disease virus antigens
    I Fodor
    Agricultural Biotechnology Centre, Godollo, Hungary
    Acta Vet Hung 47:481-92. 1999
    ..However, plasmids encoding VP2-VP4-VP3 induced IBDV-specific antibodies and protection in the chickens. DNA immunisation opens a new approach to the development of gene vaccines for chickens against infectious diseases...
  49. ncbi Detection of infectious bursal disease virus in various lymphoid tissues of experimentally infected specific pathogen free chickens by different reverse transcription polymerase chain reaction assays
    Susanne Kabell
    Danish Institute for Food and Veterinary Research, Hangovej 2, DK 8200 Aarhus N, Denmark
    Avian Dis 49:534-9. 2005
    ..All three of the IBDV strains used were detected in bursa tissues, whereas only the two virulent strains were detected in bone marrow, spleen, and thymus...
  50. ncbi Extracellular matrix distribution and islet morphology in the early postnatal pancreas: anomalies in the non-obese diabetic mouse
    Sacha Brigitte Geutskens
    Department of Immunology, Erasmus MC, Dr Molewaterplein 50, PO Box 1738, 3015 GE, Rotterdam, The Netherlands
    Cell Tissue Res 318:579-89. 2004
    ..In conclusion, increased levels of the extracellular matrix protein fibronectin were found in the early postnatal NOD pancreas, and this is associated with an enhanced accumulation of macrophages and altered islet morphology...
  51. ncbi Argentine strain of equine herpesvirus 1 isolated from an aborted foetus shows low virulence in mouse respiratory and abortion models
    C M Galosi
    Department of Virology, Faculty of Veterinary Sciences, National University of La Plata, 60 and 118, P O Box 296, 1900 La Plata, Bs As, Argentina
    Vet Microbiol 103:1-12. 2004
    ..More specific studies about genomic alterations to the SPv are necessary for identifying, more clearly, if the intra-strain variations have relation with the low virulence in the mouse respiratory and abortion model...
  52. ncbi Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control
    Anna Vossenkamper
    Abteilung für Medizinische Mikrobiologie und Infektionsimmunologie, Institut für Infektionsmedizin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Immunol 34:3197-207. 2004
    ..However, IL-12 is dominant over IL-18 in the host defense against parasite replication. Therefore, neutralization of IL-18 (rather than TNF-alpha, IL-12, and IFN-gamma) may be a safe strategy for the treatment of Th1-associated diseases...
  53. ncbi ICOS+ Th cells produce distinct cytokines in different mucosal immune responses
    Kerstin Bonhagen
    Deutsches Rheumaforschungzentrum, Berlin, Germany
    Eur J Immunol 33:392-401. 2003
    ..Thus, ICOS appears to costimulate distinct effector functions in different immune responses, depending on factors such as the nature of the antigen encountered and localization and chronicity of the immune response...
  54. pmc Pulmonary necrosis resulting from DNA vaccination against tuberculosis
    Jennifer L Taylor
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 71:2192-8. 2003
    ..tuberculosis. This previously unanticipated safety problem indicates that DNA vaccines should be used with caution in individuals who may have already been exposed to tuberculosis...
  55. ncbi Isolation of exfoliative toxin from Staphylococcus intermedius and its local toxicity in dogs
    Rie Terauchi
    Department of Veterinary Microbiology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    Vet Microbiol 94:19-29. 2003
    ..The molecular weight of the ETLT was estimated at 30 kDa by SDS-PAGE. In the present study, we propose the ETLT was a novel type of ET, S. intermedius exfoliative toxin (SIET)...
  56. ncbi Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice
    Hiroko Tanaka
    Laboratory of Microbiology, Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060 0818, Japan
    Vet Microbiol 95:1-13. 2003
    ..The results imply that neurotropism of the H5N1 virus in mice is a novel characteristic in the pathogenesis of infection by human influenza virus isolates...
  57. ncbi In vivo IgE levels in exogenous antigen stimulated responses: measurement of total IgE as a valid, simple surrogate for Ag-specific IgE
    Ian P Lewkowich
    CIHR National Training Program in Allergy and Asthma Research, University of Manitoba, Winnipeg, MB, Canada
    J Immunol Methods 286:123-32. 2004
    ....
  58. ncbi A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo
    N H R Hamilton
    John Curtin School of Medical Research JCSMR, Australian National University, Canberra, Australian Capital Territory, Australia
    Scand J Immunol 59:246-54. 2004
    ..The data presented here show that I-TAC can have an important role during virus infections and that vaccinia has evolved ways to avoid inducing I-TAC expression...
  59. ncbi Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-alpha therapy
    Jason C Lenzo
    Division of Health Sciences, Murdoch University, South Street, Perth 6150, Australia
    Cell Immunol 223:77-86. 2003
    ..These results suggest that IFN subtype therapy may have immunomodulating effects in reducing disease severity in BALB/c mice via regulation of cytokine production in the heart...
  60. ncbi Effect of temperature control upon a mouse model of partial hepatic ischaemia/reperfusion injury
    L Devey
    Liver Research Group, Institute of Biomedical Research, University of Birmingham, 5th Floor, Wolfson Drive, Edgbaston, Birmingham B15 2TT, UK
    Lab Anim 42:12-8. 2008
    ..The use of homeothermic warming systems is recommended and conversely, the use of thermostatically controlled warming mats is to be avoided in these models...
  61. ncbi Enhancement of antitumor effects of paclitaxel (taxol) in combination with red ginseng acidic polysaccharide (RGAP)
    Han Jae Shin
    KT and G Central Research Institute, Daejeon, Korea
    Planta Med 70:1033-8. 2004
    ..The above results suggest that clinical trials of RGAP as an adjuvant in cancer chemotherapy of paclitaxel are highly feasible...
  62. pmc Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies
    Rene Alvarez
    Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 78:14003-11. 2004
    ..This study shows that BALB/c mice are amenable for HMPV studies and indicates that HMPV persists as infectious virus in the lungs of normal mice for several weeks postinfection...
  63. pmc Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection
    John A Rutigliano
    Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 2502, 40 Convent Drive, MSC 3017, Bethesda, MD 20892 3017, USA
    Virology 362:314-9. 2007
    ..The hybrid mouse model provides a system to define rules of epitope hierarchy and better understand how antigen presentation and epitope competition affect the phenotype of effector and memory T cells...
  64. ncbi Protective immunity conferred by recombinant Pasteurella multocida lipoprotein E (PlpE)
    Jin Ru Wu
    Graduate Institute of Veterinary Microbiology, National Chung Hsing University, Taichung 402, Taiwan
    Vaccine 25:4140-8. 2007
    ..multocida exhibited 90.8-100% sequence identity to each other, suggesting that PlpE might serve as a cross-protective antigen. This is the first report of a recombinant P. multocida antigen that confers cross protection on animals...
  65. ncbi Mammary tumor modifiers in BALB/cJ mice heterozygous for p53
    Joanna G Koch
    The University of Texas Graduate School of Biomedical Sciences and the Department of Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mamm Genome 18:300-9. 2007
    ..The second modifier mapped is Mtsm2, a recessive-acting modifier. Mtsm2 is located on chromosome X and is significantly linked to mammary tumorigenesis (p = 1.03 x 10(-7))...
  66. ncbi The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model
    J Alayan
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, QLD, Australia
    Oral Microbiol Immunol 22:304-12. 2007
    ..Periodontal disease results from the interaction of the host with bacterial products, and T-cell-derived cytokines remain critical in the immunoregulation of periodontal disease...
  67. pmc Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites
    Robin A Herlands
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Eur J Immunol 37:3339-51. 2007
    ..This system provides a window on the initiation of an autoantibody response and reveals authentic initiators of it...
  68. pmc Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model
    Long P Nguyen
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, 4800 Calhoun, Houston, TX 77204 5037, USA
    Am J Respir Cell Mol Biol 38:256-62. 2008
    ..Similar to heart failure, our results provide a second disease model in which beta-blockers producing an acutely detrimental effect may provide a therapeutically beneficial effect with chronic administration...
  69. pmc A Francisella mutant in lipid A carbohydrate modification elicits protective immunity
    Duangjit Kanistanon
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 4:e24. 2008
    ....
  70. pmc Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC)
    Kimberly M Roth
    Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA
    FEMS Immunol Med Microbiol 53:72-8. 2008
    ..Depletion of lung macrophages prior to infection markedly reduces pericarditis and calcification in BALB/c mice but does not increase their susceptibility to infection...
  71. ncbi H5 antibody detection by blocking enzyme-linked immunosorbent assay using a monoclonal antibody
    Yi Cheng Chen
    Department of Veterinary Medicine, National Taiwan University, No 1 Sec 4, Roosevelt Road, Taipei 10617, Taiwan
    Avian Dis 52:124-9. 2008
    ..The results showed that the sensitivity and specificity of this ELISA were 98.3% (232/236) and 95.9% (232/242), respectively. This blocking ELISA could be used specifically for detecting the H5 humoral responses in chickens...
  72. pmc Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis
    Esther Vicente
    Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada, Universidad de Navarra, Irunlarrea, Pamplona, Spain
    Antimicrob Agents Chemother 52:3321-6. 2008
    ..These data indicate that 1,4-di-N-oxide quinoxalines hold promise for the treatment of tuberculosis...
  73. ncbi A rodent model for allergic dermatitis induced by flea antigens
    Lin Zhao
    College of Biological Science, China Agricultural University, Beijing 100094, China
    Vet Immunol Immunopathol 114:285-96. 2006
    ....
  74. ncbi Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice
    Junko Tashiro-Yamaji
    Department of Physiology, Osaka Medical College, Takatsuki 569 8686, Japan
    Gene 384:1-8. 2006
    ..These results demonstrate that a novel receptor (MMR2) for H-2K(d) molecules was induced on effector macrophages responsible for allograft (H-2D(d)K(d)) rejection by H-2D(b)K(b) mice...
  75. ncbi Fowl cholera outbreak in domestic poultry and epidemiological properties of Pasteurella multocida isolate
    Yong Ku Woo
    Institute of Laboratory Animal Resources, Seoul National University, San 56 1, Silim Dong, Gwanak Gu, Seoul, 151 742, Republic of Korea
    J Microbiol 44:344-53. 2006
    ..An examination of the origin of the wild bird bacteria was conducted, but no evidence has been identified that PM strains from the wild bird were introduced into domestic poultry farms...
  76. ncbi Pristane-induced autoimmunity in germ-free mice
    Akiei Mizutani
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Clin Immunol 114:110-8. 2005
    ..Although microbial stimulation acts synergistically with pristane, these results clearly indicate that pristane does not act merely by increasing exposure to microbial products such as LPS...
  77. ncbi Clinicopathological characterization of monkey B virus (Cercopithecine herpesvirus 1) infection in mice
    J W Ritchey
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078 2007, USA
    J Comp Pathol 132:202-17. 2005
    ..Viral antigen was detected immunohistochemically in the lesions. The results indicated an ascending encephalomyelitis syndrome similar to that produced by BV in man...
  78. ncbi Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation
    Anthony Stallion
    Department of Pediatric Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4952, USA
    J Pediatr Surg 40:470-7. 2005
    ....
  79. ncbi Rapid emergence of escape mutants following infection with murine cytomegalovirus in immunodeficient mice
    Anthony R French
    Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Immunol 115:61-9. 2005
    ..These findings suggest that late recrudescence of viral infections in certain clinical settings may also be due to viral escape from NK cells or other components of innate immunity...
  80. pmc Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 49:2294-301. 2005
    ..These data indicate that there is significant potential for effective oral delivery of PA-824 for the treatment of tuberculosis...
  81. ncbi Oxidant stress modulates murine allergic airway responses
    Megha Talati
    Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 40:1210-9. 2006
    ..Oxidant stress plays a role in the production of airway responsiveness...
  82. ncbi Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice
    Mathieu Barrier
    Laboratoire Contrôle et Immunologie des Maladies Entériques du Nouveau né, UR1282 Infectiologie Animale et Santé Publique, Institut National de la Recherche Agronomique de Tours, Nouzilly, France
    J Infect Dis 193:1400-7. 2006
    ..Recent advances in immunostimulatory treatments based on conserved microbial components led us to assess the potential of oligodeoxynucleotides (ODNs) for decreasing the sensitivity of neonates to Cryptosporidium parvum infection...
  83. ncbi Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model
    Kenichi Miyamoto
    Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 140:215-22. 2006
    ..The present study evaluated the role of histamine H1 receptors in airway allergic inflammation by comparing the development of bronchial asthma in histamine H1 receptor gene knockout (H1RKO) and wild-type mice...
  84. ncbi Migration of Neodiplostomum leei (Digenea: Neodiplostomidae) neodiplostomula to the livers of various mammals
    Eun Hee Shin
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, Korea
    J Parasitol 92:223-9. 2006
    ..The possibility of human infections, i.e., liver migration, by N. leei neodiplostomula, among snake consumers, warrants investigation...
  85. ncbi Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts
    Eun Mi Lee
    Xenotransplantation Research Center and Transplantation Research Institute, Seoul National University Hospital, Seoul, Korea
    Xenotransplantation 13:328-36. 2006
    ....
  86. ncbi Evaluation of immunization with tachyzoite excreted-secreted proteins in a novel susceptible mouse model (A/Sn) for Toxoplasma gondii
    Thais A Costa-Silva
    Department of Parasitology, Instituto Adolfo Lutz, Laboratorio de Parasitologia, Sao Paulo, SP, Brazil
    Exp Parasitol 120:227-34. 2008
    ..Even though the tachyzoite challenge was lethal to the mice, PCR results suggested that immunized mice had lower parasitemia as well as longer survival (72 h) than mice from the control group...
  87. ncbi Characterization of monoclonal antibodies against avian reovirus S1133 protein sigmaA synthesized in Escherichia coli
    Wan Chain Pai
    Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 403, Taiwan
    Vet Microbiol 91:309-23. 2003
    ..These results indicated that the MAb capture ELISA is a useful methods for the detection of avian reovirus from chickens suspected to have avian reovirus infections...
  88. ncbi Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    J Derbinski
    Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, INF 280, D-69120, Germany
    Nat Immunol 2:1032-9. 2001
    ..However, the array of promiscuously expressed self-antigens appeared random rather than selected and was not confined to secluded self-antigens...
  89. ncbi CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms
    Akira Suto
    Department of Internal Medicine II, the Core Research for Evolutional Science and Technology Project, and Chiba University, Japan
    Blood 99:555-60. 2002
    ..Together, these results indicate that the development of CD4(+)CD25(+) T cells in thymus and the homeostasis of CD4(+)CD25(+) T cells in periphery are regulated by distinct mechanisms...
  90. ncbi Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis
    E Gerhardt
    Laboratory of Neurodegeneration, , , Germany
    Mol Cell Neurosci 17:717-31. 2001
    ..Thus, neuronal apoptosis triggered by potassium deprivation is death receptor-independent but involves the mitochondrial pathway of caspase activation...
  91. ncbi Natural resistance to Mycoplasma pulmonis infection in mice: host resistance gene(s) map to chromosome 4
    W C Lai
    Division of Comparative Medicine, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
    Nat Immun 15:241-8. 1996
    ....
  92. ncbi Polyphasic typing of Cryptosporidium baileyi: a suggested model for characterization of cryptosporidia
    Z Egyed
    Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary
    J Parasitol 88:237-43. 2002
    ..baileyi and the isolate is similar in magnitude to that observed between most closely related Cryptosporidium species...
  93. ncbi Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice
    L A Ortiz
    Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112 2699, USA
    Exp Lung Res 24:721-43. 1998
    ..These results provide further support for a role of macrophages and TNF in the induction of lung inflammation...
  94. ncbi Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1
    Luis A Ortiz
    Section of Pulmonary Diseases, Critical Care, and Environmental Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112 2699, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1209-21. 2002
    ..These results suggest that ACE inhibitor treatment decreases lung injury and the development of pulmonary hypertension in bleomycin-treated mice...
  95. ncbi Characterization of monoclonal antibodies against the second-generation schizonts of Leucocytozoon caulleryi
    Tohru Gotanda
    Research Center for Veterinary Science, The Kitasato Institute, Kitamoto, Saitama, Japan
    J Vet Med Sci 64:281-3. 2002
    ..caulleryi. These results suggest that MAbs, R1 and M5, recognize 2GS antigen of L caulleryi...
  96. ncbi Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: a role for Th1 cells in the protective immunity
    B Keogh
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, University College Dublin, Ballsbridge, Dublin 4, Ireland
    J Neuroimmunol 125:15-22. 2002
    ..The findings indicate that type 1 T cells play a role in the control of SFV replication but not directly in SFV-induced pathology in the CNS...
  97. ncbi Epitopes involved in antibody-mediated protection from Ebola virus
    J A Wilson
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Science 287:1664-6. 2000
    ..The identification of protective mAbs has important implications for developing vaccines and therapies for Ebola virus...
  98. ncbi Detection of infectious bursal disease vaccine viruses in lymphoid tissues after in ovo vaccination of specific-pathogen-free embryos
    M M Corley
    Department of Poultry Science, Alabama Agricultural Experimental Station, Auburn University, 36849, USA
    Avian Dis 45:897-905. 2001
    ..Bursa weight: body weight ratios in IBDV-ICX-vaccinated unchallenged and vaccinated challenged birds were not different (P < 0.05)...
  99. ncbi Organ-specific distribution of CD4+ T1/ST2+ Th2 cells in Leishmania major infection
    Pascale Kropf
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:2450-9. 2002
    ..Since the majority of parasites persist at the local site of infection in nonhealing BALB/c mice, these results show that CD4(+) T1/ST2(+) T cells are localized at the site of active infection and inflammation in this model...
  100. ncbi The mechanism of a defective IFN-gamma response to bacterial toxins in an atopic dermatitis model, NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-18 on dermatitis
    Y Habu
    Division of Basic Traumatology, National Defense Medical College Research Institute, Tokorozawa, Japan
    J Immunol 166:5439-47. 2001
    ....
  101. ncbi Role of the mar locus in virulence of Salmonella enterica serovar Typhimurium DT104 in chickens
    L P Randall
    Department of Bacteriological Diseases, Veterinary Laboratories Agency (Weybridge, New Haw, Addlestone, Surrey
    J Med Microbiol 50:770-9. 2001
    ..Further work is needed to elucidate how mar is involved in virulence and if its inactivation can minimise the ability of bacteria to become antibiotic-resistant in vivo...

Research Grants63

  1. Role of Gender-associated Microbiota in Organ-specific Autoimmunity
    Martin A Kriegel; Fiscal Year: 2013
    ....
  2. Impact of CR on inflammasome driven immune-metabolic interactions.
    Vishwa Deep Dixit; Fiscal Year: 2013
    ....
  3. Type 1 diabetes: the role of commensal microbiota
    Alexander V Chervonsky; Fiscal Year: 2013
    ....
  4. GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUES: AIDS: HIV GENOME
    Nicholas William Lerche; Fiscal Year: 2011
    ..This multiplex system will allow for high throughput screening at reduced cost and will be used in support of the SPF colony development. ..
  5. In vivo systems level analysis of gene-environment interactions
    Robert L Tanguay; Fiscal Year: 2010
    ..Current procedures evaluate only about 60 chemicals a year. ..
  6. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    LARRY BILL CUMMINS; Fiscal Year: 2011
    ..abstract_text> ..
  7. National Gnotobiotic Rodent Resource Center
    Ryan B Sartor; Fiscal Year: 2013
    ..abstract_text> ..
  8. Environment, innate immunity and type 1 diabetes
    Li Wen; Fiscal Year: 2013
    ..In turn, this may help to direct investigation in people genetically susceptible to diabetes and aid development of new strategies for prevention and treatment of type 1 diabetes. ..
  9. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    John L Vandeberg; Fiscal Year: 2013
    ..abstract_text> ..
  10. Enhancement of the Integrated Aquatic Biomedical Models Facility Core
    Robert L Tanguay; Fiscal Year: 2011
    ..This will add to SARL's unique capabilities to probe the effects of nutritional deficiencies to be investigated in zebrafish. ..
  11. B. subtilis Reduces Intestinal Inflammation via TLR Signaling and B1 Lymphocytes
    SARA ELIZABETH JONES; Fiscal Year: 2012
    ..By improving our current knowledge of how commensals and the host cooperate to prevent inflammation, we could better utilize commensals to prevent disease induced by pathogenic bacteria. ..
  12. GOBLET CELLS IN INTESTINAL IMMUNE HOMEOSTATSIS
    Rodney D Newberry; Fiscal Year: 2013
    ..Understandning GAP regulation and the role of GAPs in intestinal immune homeostasis may offer new therapeutic interventions for intestinal inflammatory diseases and avenues to optimize oral vaccines. ..
  13. Caliper Life Sciences IVIS Lumina II imaging system
    Brad T Cookson; Fiscal Year: 2012
    ..Thus, important diagnostic and potentially therapeutic information about important problems such as cancer, infection and autoimmune diseases will be provided from the studies in this application. ..
  14. UW SMPH CSC L3 unit rodent containment and quarantine
    CALVIN C PATTEN JR.; Fiscal Year: 2011
    ..This project will have a direct and ongoing impact on public health, by creating a better environment for our research efforts, thus furthering the study of human diseases and enabling the development of innovative treatments. ..
  15. ESTABLISHMENT OF SPF RHESUS MACAQUE BREEDING COLONY: HIV GENOME
    Keith G Mansfield; Fiscal Year: 2011
    ..abstract_text> ..
  16. The NEPRC SPF Rhesus Macaque Breeding Colony
    R Paul Johnson; Fiscal Year: 2013
    ..Specific Aim #2: Continue MHC typing and genetic testing to provide for informed colony management and well-characterized animals for AIDS-related investigations. ..
  17. Development of an SPF Macaca nemestrina Breeding Colony
    Robert J Adams; Fiscal Year: 2013
    ..3) To determine whether either MHC class I allele expression or SNPs are associated with a) SIV-related disease outcomes and b) naturally occurring enterocolitis in pig-tailed macaques. ..
  18. University of Minnesota SPF Rodent Facility Autoclave Replacement Project
    Roland Gunther; Fiscal Year: 2010
    ..Evaluation of candidate autoclaves has already been done and cost estimates for installation have already been obtained, so no funding is requested for these components of the replacement process. ..
  19. Tfh cells: linking the gut microbiota to a gut-distal autoimmune disease
    HSIN JUNG JOYCE WU; Fiscal Year: 2013
    ..This proposal will help us understand the pathogenesis of autoimmunity and provide new foundations for novel therapies.! ..
  20. SPF BREEDING COLONIES AT THE YERKES NPRC
    Mark E Wilson; Fiscal Year: 2013
    ....
  21. Tulane National Primate Research Center U24 AIDS SPF Breeding Colony Maintenance
    Rudolf P Bohm; Fiscal Year: 2013
    ....
  22. OZONE INDUCED AIRWAY EPITHELIAL HYPERPROLIFERATION
    CHRISTOPHER MURLAS; Fiscal Year: 1999
    ..It is hoped this information will increase their understanding concerning the importance of cell NEP expression in modulating airway epithelial mitogenesis, especially as it may relate to airway disease due to repeated ozone exposure. ..
  23. Goblet Cell Secretion and Antigen Delivery
    KATHRYN KNOOP; Fiscal Year: 2013
    ..Through this grant, we hope to better understand how GAPs deliver antigen for the purpose of maintaining tolerogenic immune responses. ..
  24. WaNPRC MACACA NEMESTRINA SPF BREEDING COLONY
    David M Anderson; Fiscal Year: 2011
    ..Additionally, SPF animals significantly limit the potential morbidity and/or mortality associated with zoonotic CHV transmission. ..
  25. Web Portal for Nonhuman Primate Research Models
    Joseph W Kemnitz; Fiscal Year: 2011
    ..Through the use of PrimatePortal, researchers will be able to acquire critical information regarding the appropriateness, availability and performance of studies benefiting from the use of NHP models. ..
  26. ENHANCEMENT OF THE CPRC-SPF RHESUS MONKEY PROGRAM
    Carlos A Sariol; Fiscal Year: 2013
    ..Our Center will continue to make significant contributions to AIDS and to other research programs by providing high quality, healthy, and genetically-characterized SPF rhesus monkeys to NIH-sponsored research initiatives. ..
  27. ESTABLISHMENT AND EXPANSION OF A SPF RHESUS COLONY: AIDS, GENOME
    Rudolf P Bohm; Fiscal Year: 2011
    ..Continued support of the TNPRC SPF colony will assist in alleviating the critical national shortage of well characterized rhesus monkeys for the AIDS research effort. ..
  28. Establishment &maintenance of a closed CPRC SPF colony
    EDMUNDO NELSON KRAISELBURD; Fiscal Year: 2011
    ..CPRC will continue to make significant contributions to AIDS and to other research programs by providing high quality and healthy SPF rhesus monkeys to NIH-sponsored research initiatives. ..
  29. Establishment &maintenance of a closed CPRC SPF colony
    Carlos A Sariol; Fiscal Year: 2013
    ..CPRC will continue to make significant contributions to AIDS and to other research programs by providing high quality and healthy SPF rhesus monkeys to NIH-sponsored research initiatives. ..
  30. National Swine Resource and Research Center
    Randall S Prather; Fiscal Year: 2013
    ..The NSRRC will also serve as a site for training and educational activities related to research employing swine models. ..
  31. Establishment of Specific Pathogen-Free Rhesus Macaque Colonies
    Cynthia J Doane; Fiscal Year: 2010
    ..The acquisition of additional sheltered field cage housing is proposed to support colony expansion in an environment that protects these valuable animals from infectious agents in the environment. ..
  32. SPF BREEDING COLONIES AT THE YERKES NPRC: AIDS, GENOME
    JAMES GIBSON ELSE; Fiscal Year: 2011
    ..g. per diem and use fees) from NCRR to the YNPRC (P51 - RR00165). As the SPF colony grows the conventional colony will be reduced in size, with the goal of achieving a 100% SPF rhesus breeding colony by 2013. ..
  33. PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES: AIDS
    Nicholas William Lerche; Fiscal Year: 2011
    ..These animals will be used for research related to viral pathogenesis, vaccine development and anti-viral therapy. ..
  34. BABOON RESEARCH RESOURCE PROGRAM
    Gary L White; Fiscal Year: 2013
    ..The OUHSC Baboon Research Resource continues to serve as a national source for biomedical, and behavior research. ..
  35. Movable Equipment for DDB Animal Facility
    MARVIN MICHAEL SWINDLE; Fiscal Year: 2010
    ..Maintaining an SPF environment and remaining in compliance with current and future standards of laboratory animal care and use demand the highest achievable standards of disinfection, decontamination and occupational safety. ..
  36. Maintenance of an SPF Macaque Breeding Colony for AIDS Research
    James L Blanchard; Fiscal Year: 2013
    ..The colony has reached a mature status with ideal demographics to produce 150 animals available for assignment each year. ..
  37. PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES
    DALLAS MELVIN HYDE; Fiscal Year: 2013
    ..These animals will be used for research related to viral pathogenesis, vaccine development and anti-viral therapy. ..
  38. Nonhuman Primate Housing Infrastructure and Caging
    Jeffrey S Flier; Fiscal Year: 2011
    ..The project will directly benefit the national resource mission of the NEPRC and promote the availability and efficient utilization of resources by investigators conducting NIH-funded biomedical research. ..
  39. DEVELOPMENT OF A SPF PIGTAIL MACAQUE BREEDING COLONY
    ROBERT DRUILHET; Fiscal Year: 2000
    ..Feral pigtails and progeny, which do not qualify for retention, and all excess male progeny which may be SPF defined, are to be made available to the biomedical research community. ..
  40. SPF RODENT HOUSING RENOVATION
    BEVERLY JAN GNADT; Fiscal Year: 2010
    ....
  41. BACTERIAL INDUCED COLITIS IN HLA-B27 RATS
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..This expertise will foster the development of an independent investigator with skills in both clinical and basic science. ..
  42. OUHSC Specific Pathogen Free Baboon Research Resource
    Roman F Wolf; Fiscal Year: 2013
    ..The long term objective is for the SPF baboon colony to be a stable, self-sustaining breeding colony that produces ~100 SPF baboons/year for use in NIH-funded biomedical research. ..
  43. ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS GENOME
    Michael K Axthelm; Fiscal Year: 2011
    ..abstract_text> ..
  44. Purchase of IVC Caging Systems for Mice and Rats in Dunning Hall
    Robert J Adams; Fiscal Year: 2012
    ..6 million in grant support from the NIH. ..
  45. MAINTENANCE OF A RODENT BREEDING AND HOLDING FACILITY
    RONALD SCHUELER; Fiscal Year: 1993
    ..In addition the Contractor must continue to provide technical support (bleeding, immunization, organ harvest, delivering animals and animals products) to NIAID scientists utilizing the facilities at Spring Valley Laboratories...
  46. SPECIFIC PATHOGEN FREE MACAQUE BREEDING PROGRAM
    M Izard; Fiscal Year: 1999
    ....
  47. WaNPRC MACACA NEMESTRINA SPF BREEDING COLONY
    DONALD RICK LEE; Fiscal Year: 2013
    ..This foundation will be expanded to ensure continued successful expansion of this important SPF macaque colony. ..
  48. Improving WNPRC Infrastructure to Support HIV/AIDS Research
    SAVERIO VINCENT CAPUANO; Fiscal Year: 2011
    ..Successful completion of the aims outlined in this proposal will ensure that WNPRC investigators performing ZHIV/AIDS research are provided with quality animals and that the psychological health of these animals is protected. ..
  49. INCIDENTAL INFECTIOUS DISEASES AS COFACTORS
    Niels Pedersen; Fiscal Year: 1993
    ..Conversely, we are interested in seeing whether coinfection of FIV infected cats with any of these agents alters the levels of FIV in their blood or accelerates their immunologic decline...
  50. CYTOKINE RESPONSE IN FIV AND SIV IMMUNODEFICIENCY
    Gregg Dean; Fiscal Year: 2002
    ..ft. of laboratory space, startup funds, access to the central equipment laboratory, and three years of support for a technical assistant. ..
  51. Establishment of Specific Pathogen Free Rhesus Macaques Colonies (U42)
    Kerry L Taylor; Fiscal Year: 2013
    ..The purposes of this proposal are to continue to support and characterize the specific pathogen-free Indian rhesus AIDS Research Colony resource that was established in the past ten-year grant period. ..
  52. Maintainance of an SPF Macaque breeding colony for AIDS Research
    James L Blanchard; Fiscal Year: 2011
    ..Beginning in year 2, revenue from animal sales will be returned to the grant as program income. This will begin the process of transition to a self-sustaining colony, which will be achieved by the end of the grant period. ..
  53. Molecular Oncology and Toxicology Support
    MOSER GLENDA; Fiscal Year: 2009
    ....
  54. Development and Improvement of an Animal Resource Core
    Dale Bredesen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. NEUROTROPIC RETROVIRUSES
    LAWRENCE WHALEN; Fiscal Year: 1993
    ..A biologically defined FIV model for lentivirus-induced neurologic disease will be established using MC-FIVs, and we will begin to define the genetic structures of neurotropic FIVs. ..
  56. Small Animal Ultrasound System (VisualSonics Vevo 770)
    Ralph Mason; Fiscal Year: 2009
    ..It will serve multiple research groups in the preclinical setting, but we believe the results achieved should provide insight into optimizing therapy protocols for patients. ..
  57. MECHANISMS OF RETROVIRUS INDUCED APLASTIC ANEMIA
    Edward Hoover; Fiscal Year: 1992
    ..We will then examine the selective binding of gp70 to bone marrow cells and fibroblasts and to identify and clone the receptors for FeLV-C study and their role of this initial virus/cell interaction in the genesis of erythroid aplasia...
  58. Improvement of Facilities Used for BL2 Animal Research
    JAMES MACY; Fiscal Year: 2005
    ..abstract_text> ..
  59. Mechanisms of bacterial-induced colitis in HLA-B27 rats
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..2. Investigate if protective immune responses are mediated by L.GG-specific inhibitory T lymphocytes. ..
  60. Innovative Nursery-Rearing for Improving Rhesus Macaques as Biomedical Models
    Brenda McCowan; Fiscal Year: 2009
    ....
  61. Mutant Mouse Aging Colony
    RICHARD MATACCHIERO; Fiscal Year: 2012
    ..Sharing of genetically engineered and naturally occurring mutant mouse models between labs greatly enhances the research opportunities and generation of new information...
  62. Mutant Mouse Aging Colony
    RICHARD MATACCHIERO; Fiscal Year: 2013
    ..Sharing of genetically engineered and naturally occurring mutant mouse models between labs greatly enhances the research opportunities and generation of new information. ..
  63. Mutant Mouse Aging Colony
    RICHARD MATACCHIERO; Fiscal Year: 2009
    ..Sharing of genetically engineered and naturally occurring mutant mouse models between labs greatly enhances the research opportunities and generation of new information...