biophysics

Summary

Top Publications

  1. pmc Biomechanics and biophysics of cancer cells
    Subra Suresh
    Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 3:413-38. 2007
  2. ncbi Emerging issues of connexin channels: biophysics fills the gap
    A L Harris
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
    Q Rev Biophys 34:325-472. 2001
  3. pmc Protein stability imposes limits on organism complexity and speed of molecular evolution
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:16152-7. 2007
  4. ncbi Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications
    M C Pedroso de Lima
    Department of Biochemistry, University of Coimbra, 3000 codex, Coimbra, Portugal
    Adv Drug Deliv Rev 47:277-94. 2001
  5. ncbi Unusual biophysics of intrinsically disordered proteins
    Vladimir N Uversky
    Department of Molecular Medicine, University of South Florida, Tampa, FL, USA
    Biochim Biophys Acta 1834:932-51. 2013
  6. ncbi Beyond bistability: biophysics and temporal dynamics of working memory
    D Durstewitz
    Centre for Theoretical and Computational Neuroscience, University of Plymouth, A 220 Portland Square, Drake Circus, Plymouth PL4 8AA, UK
    Neuroscience 139:119-33. 2006
  7. ncbi Implications of synaptic biophysics for recurrent network dynamics and active memory
    Daniel Durstewitz
    Central Institute of Mental Health, RG Computational Neuroscience, and Interdisciplinary Center for Neurosciences, University of Heidelberg, Mannheim, Germany
    Neural Netw 22:1189-200. 2009
  8. ncbi Large-scale biophysics: ion flows and regeneration
    Michael Levin
    Center for Regenerative and Developmental Biology, Forsyth Institute and Developmental Biology Department, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Trends Cell Biol 17:261-70. 2007
  9. ncbi The physics, biophysics and technology of photodynamic therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Phys Med Biol 53:R61-109. 2008
  10. pmc Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein
    Vladimir N Uversky
    Institite for Intrinsically Disordered Protein Research, Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Protein Pept Sci 10:483-99. 2009

Detail Information

Publications330 found, 100 shown here

  1. pmc Biomechanics and biophysics of cancer cells
    Subra Suresh
    Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 3:413-38. 2007
    ..presents an overview of the rapidly expanding, nascent field of research that deals with the biomechanics and biophysics of cancer cells...
  2. ncbi Emerging issues of connexin channels: biophysics fills the gap
    A L Harris
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
    Q Rev Biophys 34:325-472. 2001
    ..However, the relation between these two mechanisms are unexplored, as are specific mechanisms of direct endogenous regulation of connexin channel activity. (ABSTRACT TRUNCATED)..
  3. pmc Protein stability imposes limits on organism complexity and speed of molecular evolution
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:16152-7. 2007
    ....
  4. ncbi Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications
    M C Pedroso de Lima
    Department of Biochemistry, University of Coimbra, 3000 codex, Coimbra, Portugal
    Adv Drug Deliv Rev 47:277-94. 2001
    ....
  5. ncbi Unusual biophysics of intrinsically disordered proteins
    Vladimir N Uversky
    Department of Molecular Medicine, University of South Florida, Tampa, FL, USA
    Biochim Biophys Acta 1834:932-51. 2013
    ..All this requires a close attention to the peculiarities of biophysics of these proteins. In this review, some key biophysical features of IDPs are covered...
  6. ncbi Beyond bistability: biophysics and temporal dynamics of working memory
    D Durstewitz
    Centre for Theoretical and Computational Neuroscience, University of Plymouth, A 220 Portland Square, Drake Circus, Plymouth PL4 8AA, UK
    Neuroscience 139:119-33. 2006
    ..Together such findings may lay the foundations for highly dynamical theories of working memory based on biophysical principles...
  7. ncbi Implications of synaptic biophysics for recurrent network dynamics and active memory
    Daniel Durstewitz
    Central Institute of Mental Health, RG Computational Neuroscience, and Interdisciplinary Center for Neurosciences, University of Heidelberg, Mannheim, Germany
    Neural Netw 22:1189-200. 2009
    ..In this sense, this article is a plead for taking the specific biophysics of real neurons and synapses seriously when trying to account for the neurobiology of cognition.
  8. ncbi Large-scale biophysics: ion flows and regeneration
    Michael Levin
    Center for Regenerative and Developmental Biology, Forsyth Institute and Developmental Biology Department, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Trends Cell Biol 17:261-70. 2007
    ....
  9. ncbi The physics, biophysics and technology of photodynamic therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Phys Med Biol 53:R61-109. 2008
    ..This paper reviews the current status of PDT with an emphasis on the contributions of physics, biophysics and technology, and the challenges remaining in the optimization and adoption of this treatment modality...
  10. pmc Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein
    Vladimir N Uversky
    Institite for Intrinsically Disordered Protein Research, Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Protein Pept Sci 10:483-99. 2009
    ..This review focuses on the contributions of Prof. Anthony L. Fink to the field and presents some recent developments in this exciting area...
  11. pmc Structure and biophysics of type III secretion in bacteria
    Srirupa Chatterjee
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    Biochemistry 52:2508-17. 2013
    ..This review will focus on the latest developments and future challenges concerning the structure and biophysics of the needle apparatus.
  12. ncbi A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee
    S Groppa
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Clin Neurophysiol 123:858-82. 2012
    ..Additional sections cover safety issues, the triple stimulation technique, and neuropediatric aspects of TMS...
  13. pmc A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy
    Jeanne T Paz
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
    Nat Neurosci 14:1167-73. 2011
    ..This mode could be active under other circumstances, representing a previously unknown channel of cortico-thalamo-cortical information processing...
  14. ncbi Time-resolved methods in biophysics. 3. Fluorescence lifetime correlation spectroscopy
    Ingo Gregor
    Institute for Biological Information Processing 1, Forschungszentrum Julich, D 52425, Julich, Germany
    Photochem Photobiol Sci 6:13-8. 2007
    ..The theoretical basis of FLCS is explained, and the method is applied to the study of a dynamic transition between two fluorescence lifetime states in a dye-protein complex...
  15. ncbi Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells
    Andrea Marcantoni
    Department of Neuroscience, Nanostructured Interfaces and Surfaces Centre of Excellence, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, 10125 Torino, Italy
    J Neurosci 30:491-504. 2010
    ..2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress...
  16. pmc Distinct membrane mechanical properties of human mesenchymal stem cells determined using laser optical tweezers
    Igor Titushkin
    Department of Bioengineering, University of Illinois, Chicago, Illinois 60607, USA
    Biophys J 90:2582-91. 2006
    ..We postulate that whereas fibroblasts use both the membrane rigidity and membrane-cytoskeleton association to regulate their membrane reservoir, hMSC cytoskeleton has only a minor impact on stem cell membrane mechanics...
  17. pmc Modulation of cellular mechanics during osteogenic differentiation of human mesenchymal stem cells
    Igor Titushkin
    Department of Bioengineering, University of Illinois, Chicago, Illinois 60607, USA
    Biophys J 93:3693-702. 2007
    ....
  18. ncbi Biophysics, physiological ecology, and climate change: does mechanism matter?
    Brian Helmuth
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Annu Rev Physiol 67:177-201. 2005
    ....
  19. pmc Energetics of inclusion-induced bilayer deformations
    C Nielsen
    Department of Physiology and Biophysics, Cornell University Medical College, New York, New York 10021, USA
    Biophys J 74:1966-83. 1998
    ..3 A can increase the Boltzmann factor (the equilibrium distribution for protein conformation) 10-fold due to the elastic properties of the bilayer...
  20. ncbi Prediction of electroencephalographic spectra from neurophysiology
    P A Robinson
    School of Physics, University of Sydney, New South Wales 2006, Australia
    Phys Rev E Stat Nonlin Soft Matter Phys 63:021903. 2001
    ..Three types of potential instability are found: one at zero frequency, another in the theta band at around half the alpha frequency, and a third at the alpha frequency itself...
  21. pmc From biophysics to evolutionary genetics: statistical aspects of gene regulation
    Michael Lässig
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicher Str, 77, 50937 Koln, Germany
    BMC Bioinformatics 8:S7. 2007
    ..We focus on the links between the biophysical function and the evolution of regulatory elements. In particular, we infer fitness landscapes of binding sites from genomic data, leading to a quantitative evolutionary picture of regulation...
  22. pmc Hyperpolarization-activated graded persistent activity in the prefrontal cortex
    Milena Winograd
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    Proc Natl Acad Sci U S A 105:7298-303. 2008
    ....
  23. ncbi Missense meanderings in sequence space: a biophysical view of protein evolution
    Mark A DePristo
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Genet 6:678-87. 2005
    ..Here we review the literature on biophysics as it relates to molecular evolution, focusing on how protein stability and aggregation affect organismal ..
  24. pmc Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing
    D I Svergun
    European Molecular Biology Laboratory, Hamburg, Germany and Institute of Crystallography, Russian Academy of Sciences, Moscow, Russia
    Biophys J 76:2879-86. 1999
    ..Application of the method is illustrated by the restoration of a ribosome-like model structure and more realistically by the determination of the shape of several proteins from experimental x-ray scattering data...
  25. pmc Biophysics of α-synuclein membrane interactions
    Candace M Pfefferkorn
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochim Biophys Acta 1818:162-71. 2012
    ..Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. This article is part of a Special Issue entitled: Membrane protein structure and function...
  26. ncbi Biophysics of microchannel-enabled neuron-electrode interfaces
    Ling Wang
    Neuroengineering Group, Catalonia Bioengineering Institute IBEC, c Baldiri i Reixach 15 21, 08028 Barcelona, Spain
    J Neural Eng 9:026010. 2012
    ..Despite the low degree of complexity involved in their fabrication and use, μChannel devices provide a single-unit mean SNR of 101 ± 76, which compares favourably with the SNR obtained from typical microelectrode arrays...
  27. ncbi A method to track rotational motion for use in single-molecule biophysics
    Jan Lipfert
    Department of BioNanoScience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands
    Rev Sci Instrum 82:103707. 2011
    ..In addition, we envision uses of the algorithm in a range of biophysical measurements, including further extensions of MT, tethered particle motion, and optical trapping measurements...
  28. pmc Interlaced optical force-fluorescence measurements for single molecule biophysics
    Ricardo R Brau
    Department of Mechanical Engineering, Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biophys J 91:1069-77. 2006
    ....
  29. pmc Biophysics of malarial parasite exit from infected erythrocytes
    Rajesh Chandramohanadas
    Singapore MIT Alliance for Research and Technology Centre, Singapore, Singapore
    PLoS ONE 6:e20869. 2011
    ..These findings provide a comprehensive, previously unavailable, body of information on the combined effects of biochemical and biophysical factors on parasite egress from iRBCs...
  30. pmc Alternans resonance and propagation block during supernormal conduction in cardiac tissue with decreased [K(+)](o)
    Enno de Lange
    Department of Physiology, University of Bern, Bern, Switzerland
    Biophys J 98:1129-38. 2010
    ..We conclude that supernormal conduction potentiates alternans and spatial analysis of IBIs represents a powerful method to locate tissue heterogeneities...
  31. pmc Measuring the viscoelastic properties of human platelets with the atomic force microscope
    M Radmacher
    Department of Physics, University of California, Santa Barbara 93106, USA
    Biophys J 70:556-67. 1996
    ..The elastic moduli were in a range of 1-50 kPa measured in the frequency range of 1-50 Hz. Loading forces could be controlled with a resolution of 80 pN and indentations of the platelet could be determined with a resolution of 20 nm...
  32. pmc Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design
    Lifeng Cai
    Beijing Institute of Pharmacology and Toxicology, Haidian District, Beijing 100850, China
    Curr Top Med Chem 11:2959-84. 2011
    ....
  33. pmc Biophysics of magnetic orientation: strengthening the interface between theory and experimental design
    Joseph L Kirschvink
    Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    J R Soc Interface 7:S179-91. 2010
    ....
  34. ncbi Thermo-TRP channels: biophysics of polymodal receptors
    David Baez-Nieto
    Facultad de Ciencias, Centro Interdisciplinario de Neurociencias de Valparaíso Universidad de Valparaíso, Valparaiso, Chile
    Adv Exp Med Biol 704:469-90. 2011
    ..We conclude that the present data is most economically explained by allosteric models in which temperature, voltage, and agonists act separately to modulate channel activity...
  35. ncbi Cationic liposomes for gene delivery: from biophysics to biological applications
    M C Pedroso de Lima
    Department of Biochemistry and University of Coimbra, Coimbra, Portugal
    Curr Med Chem 10:1221-31. 2003
    ....
  36. ncbi Untreatable pain resulting from abdominal cancer: new hope from biophysics?
    Giuseppe Marineo
    Delta Research and Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy
    JOP 4:1-10. 2003
    ..Visceral pain characterizing pancreatic cancer is the most difficult symptom of the disease to control and can significantly impair the quality of life which remains and increase the demand for euthanasia...
  37. ncbi Lessons from the biophysics of interfaces: lung surfactant and tear fluid
    Antti H Rantamäki
    Helsinki Eye Lab, Department of Ophthalmology, University of Helsinki, Helsinki, Finland
    Prog Retin Eye Res 30:204-15. 2011
    ..The dynamics of this cycle have been studied to a lesser extent and are not as clear as those of lung surfactant. The common structure and properties suggest a similar behaviour under rapid compression-expansion for both fluids...
  38. pmc Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release
    Lyanne C Schlichter
    Toronto Western Research Institute, University Health Network, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Channels (Austin) 5:128-37. 2011
    ..Together, these results confirm the similarity of IClswell in the two cell types, and point to a role for this channel in inflammation-mediated glutamate release in the CNS...
  39. ncbi Dynamic causal modelling: a critical review of the biophysical and statistical foundations
    J Daunizeau
    Wellcome Trust Centre for Neuroimaging, University College of London, UK
    Neuroimage 58:312-22. 2011
    ..Finally, we discuss potential extensions of the current DCM framework, such as stochastic DCMs, plastic DCMs and field DCMs...
  40. pmc Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions
    Rachel Grashow
    Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 30:9145-56. 2010
    ..This work experimentally confirms results from previous modeling studies; tuning synaptic and intrinsic conductances can yield similar circuit outputs from neurons with variable intrinsic excitability...
  41. ncbi Propagator theory of brain dynamics
    P A Robinson
    School of Physics, University of Sydney, New South Wales, Australia
    Phys Rev E Stat Nonlin Soft Matter Phys 72:011904. 2005
    ..This resonance involves feedback loops incorporating slow, short-range inhibitory fibers...
  42. ncbi Wavelength and vulnerability to atrial fibrillation: Insights from a computer model of human atria
    Vincent Jacquemet
    Signal Processing Institute, Ecole Polytechnique Federale de Lausanne EPFL, Station 11, Switzerland
    Europace 7:83-92. 2005
    ..To explain the contradictory results related to the concept of critical cardiac wavelength in the initiation and perpetuation of atrial fibrillation (AF)...
  43. pmc Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel
    Jérôme Mathé
    Rowland Institute, Harvard University, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:12377-82. 2005
    ..Our results imply that the translocation process through a narrow pore is more complicated than previously believed and involves base tilting and stretching of ssDNA molecules inside the confining pore...
  44. pmc Electrophysiological analysis of the yeast V-type proton pump: variable coupling ratio and proton shunt
    Carsten Kettner
    Botanisches Institut I, Universitat Karlsruhe, Karlsruhe, Germany
    Biophys J 85:3730-8. 2003
    ....
  45. pmc Maximum likelihood estimation of ion channel kinetics from macroscopic currents
    Lorin S Milescu
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York, USA
    Biophys J 88:2494-515. 2005
    ..Given appropriate stimulation protocols, our method chose a reasonable model size and topology...
  46. pmc The application of statistical physics to evolutionary biology
    Guy Sella
    Center for the Study of Rationality, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 102:9541-6. 2005
    ..Finally, just as the free energy function quantitatively characterizes the balance between energy and entropy, a free fitness function provides an analytical expression for the balance between natural selection and stochastic drift...
  47. pmc Bursting activation of prefrontal cortex drives sustained up states in nucleus accumbens spiny neurons in vivo
    Aaron J Gruber
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Synapse 63:173-80. 2009
    ..Synapse 63:173-180, 2009. (c) 2008 Wiley-Liss, Inc...
  48. pmc Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution
    Chi Yuan Chou
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Biophys J 88:455-66. 2005
    ..The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD...
  49. pmc Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation
    Sandeep V Pandit
    Institute for Cardiovascular Research and Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Biophys J 88:3806-21. 2005
    ..Altering the rectification profile of I(K1) also slowed down or abolished reentrant activity. In combination, these simulation results provide novel insights into the ionic bases of a sustained rotor in a 2-D chronic AF substrate...
  50. pmc Ultrasound-biophysics mechanisms
    WILLIAM D O'BRIEN
    Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois, 405 N Mathews, Urbana, IL 61801, USA
    Prog Biophys Mol Biol 93:212-55. 2007
    Ultrasonic biophysics is the study of mechanisms responsible for how ultrasound and biological materials interact. Ultrasound-induced bioeffect or risk studies focus on issues related to the effects of ultrasound on biological materials...
  51. ncbi A biophysically based neural model of matching law behavior: melioration by stochastic synapses
    Alireza Soltani
    Volen Center for Complex Systems, Department of Physics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 26:3731-44. 2006
    ....
  52. ncbi Time-resolved methods in Biophysics. 2. Monitoring haem proteins at work with nanosecond laser flash photolysis
    Stefania Abbruzzetti
    Dipartimento di Fisica, Universita degli Studi di Parma, Parma, Italy
    Photochem Photobiol Sci 5:1109-20. 2006
    Haem proteins have long been the most studied proteins in biophysics, and have become paradigms for the characterization of fundamental biomolecular processes as ligand binding and regulatory conformational transitions...
  53. pmc Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron
    Stefanie Ryglewski
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    J Neurophysiol 102:3673-88. 2009
    ..These data can now be used to investigate the roles of Shaker and Shal for motoneuron intrinsic properties, synaptic integration, and spiking output during behavior by targeted genetic manipulations...
  54. ncbi Low conductance gap junctions mediate specific electrical coupling in body-wall muscle cells of Caenorhabditis elegans
    Qiang Liu
    Department of Neuroscience, University of Connecticut Health Center, Connecticut 06030, USA
    J Biol Chem 281:7881-9. 2006
    ..These analyses provide a relatively detailed description of innexin-based gap junctions in a native tissue and suggest that innexin-based small conductance gap junctions can play an important role in processes such as locomotion...
  55. ncbi Super-resolved FT-IR spectroscopy: Strategies, challenges, and opportunities for membrane biophysics
    Jessica J Li
    Department of Chemical Engineering and Applied Chemistry, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada M5S 3E1
    Biochim Biophys Acta 1828:2272-82. 2013
    ..The challenges and opportunities that these platforms present for examining dynamic phenomena will be discussed. This article is part of a Special Issue entitled: FTIR in membrane proteins and peptide studies. ..
  56. pmc The use of pHluorins for optical measurements of presynaptic activity
    S Sankaranarayanan
    Department of Biochemistry, The Weill Medical College of Cornell University, New York, New York 10021, USA
    Biophys J 79:2199-208. 2000
    ..A theoretical analysis of the expected signals using this approach and guidelines for future reporter development are provided...
  57. ncbi Mechanism of gain modulation at single neuron and network levels
    M Brozovic
    Division of Biology, Mail code 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    J Comput Neurosci 25:158-68. 2008
    ....
  58. pmc Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers
    J Dai
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biophys J 68:988-96. 1995
    ..These results indicate that the actin cytoskeleton affects the membrane mechanical properties, including the force required for membrane extension and the viscoelastic behavior...
  59. pmc On the biophysics of cathodal galvanotaxis in rat prostate cancer cells: Poisson-Nernst-Planck equation approach
    Przemysław Borys
    Department of Physical Chemistry and Technology of Polymers, Section of Physics and Applied Mathematics, Silesian University of Technology, 44 100 Ks M Strzody 9, Gliwice, Poland
    Eur Biophys J 41:527-34. 2012
    ..The disturbance in the calcium distribution may then drive actin polymerization and myosin contraction. The presented modeling is done within a continuous one-dimensional Poisson-Nernst-Planck equation framework...
  60. ncbi Advances in magnetic tweezers for single molecule and cell biophysics
    Devrim Kilinc
    UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Integr Biol (Camb) 6:27-34. 2014
    ..We review recent MTW studies in single molecule and cell biophysics that demonstrate the flexibility of this technique...
  61. ncbi Cellular biophysics: bacterial endospore, membranes and random fluctuation
    Vladimir Lizunov
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1855, USA
    Curr Biol 16:R1025-8. 2006
    ....
  62. pmc Single-molecule biophysics: at the interface of biology, physics and chemistry
    Ashok A Deniz
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J R Soc Interface 5:15-45. 2008
    ..This review presents an overview of the burgeoning field of single-molecule biophysics, discussing key highlights and selected examples from its genesis to our projections for its future...
  63. pmc Doing molecular biophysics: finding, naming, and picturing signal within complexity
    Jane S Richardson
    Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA
    Annu Rev Biophys 42:1-28. 2013
    ..Here we relate parts of our scientific and personal lives, including ups and downs, influences, anecdotes, and guiding principles such as the title theme...
  64. ncbi Manipulating forces between surfaces: applications in colloid science and biophysics
    Paul F Luckham
    Department Chemical Engineering and Chemical Technology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BY, UK
    Adv Colloid Interface Sci 111:29-47. 2004
    ....
  65. doi Biophysics. Enigmas of blood clot elasticity
    John W Weisel
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 320:456-7. 2008
  66. ncbi Virtual radiation biophysics: implications of nuclear structure
    G Kreth
    Kirchhoff Institute for Physics, INF 227 Heidelberg, Germany
    Cytogenet Genome Res 104:157-61. 2004
    ..Regarding one-chromosome yields, remarkable differences for single CTs were observed taking into account the gene density-correlated distribution of CTs...
  67. ncbi Time-resolved methods in biophysics. 10. Time-resolved FT-IR difference spectroscopy and the application to membrane proteins
    Ionela Radu
    Bielefeld University, Department of Chemistry, Biophysical Chemistry, 33615, Bielefeld, Germany
    Photochem Photobiol Sci 8:1517-28. 2009
    ..Examples of applications to retinal proteins and energy transduction complexes are reviewed, which emphasize the impact of time-resolved FT-IR spectroscopy on the understanding of protein reactions on the level of single bonds...
  68. pmc Dynamics of human atrial cell models: restitution, memory, and intracellular calcium dynamics in single cells
    Elizabeth M Cherry
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Prog Biophys Mol Biol 98:24-37. 2008
    ....
  69. ncbi Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock
    Letteria Minutoli
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Eur J Pharmacol 589:272-80. 2008
    ..In addition we performed a biophysics experiment by quasi elastic neutron scattering (QENS) study, to investigate whether the membrane stability ..
  70. ncbi Biophysics and dynamics of natural and engineered stem cell microenvironments
    Albert J Keung
    Department of Chemical Engineering, University of California, Berkeley, CA, USA
    Wiley Interdiscip Rev Syst Biol Med 2:49-64. 2010
    ....
  71. ncbi The light-induced reduction of horizontal cell receptive field size in the goldfish retina involves nitric oxide
    Bryan A Daniels
    Department of Anatomy and Neurobiology, Laboratory for Retina and Optic Nerve Research, Dalhousie University, Halifax, Nova Scotia, Canada
    Vis Neurosci 28:137-44. 2011
    ..These findings suggest that nitric oxide is involved in light-induced reduction of horizontal cell receptive field size...
  72. ncbi Biology and biophysics of the nuclear pore complex and its components
    Roderick Y H Lim
    M E Müller Institute for Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Int Rev Cell Mol Biol 267:299-342. 2008
    ....
  73. ncbi Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure
    C Smith
    Australian Centre for Vaccine Development, Tumour Immunology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Am J Transplant 12:15-26. 2012
    ....
  74. pmc Multiple events on single molecules: unbiased estimation in single-molecule biophysics
    Daniel A Koster
    Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
    Proc Natl Acad Sci U S A 103:1750-5. 2006
    ..We demonstrate the potential of the method for a number of single-molecule experiments, focusing on the removal of DNA supercoils by topoisomerase IB, and validate the method by numerical simulation of the experiment...
  75. pmc Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets
    Michele Ferrante
    Krasnow Institute for Advanced Study, George Mason University, 4400 University Drive, MS 2A1, Fairfax, Virginia 22030 4444, USA
    Curr Med Chem 15:2456-71. 2008
    ....
  76. ncbi From autopoiesis to neurophenomenology: Francisco Varela's exploration of the biophysics of being
    David Rudrauf
    Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, CNRS UPR 640, Hopital de la Pitie Salpetriere, 47 bd de l Hopital, 75651, Paris, France
    Biol Res 36:27-65. 2003
    ..Finally, we discuss Varela's essential contribution to our understanding of the generation of consciousness in the framework of what we call his "biophysics of being."
  77. ncbi Unifying constructal theory for scale effects in running, swimming and flying
    Adrian Bejan
    Duke University, Department of Mechanical Engineering and Materials Science, Durham, NC 27708 0300, USA
    J Exp Biol 209:238-48. 2006
    ..This theory, and the general body of work known as constructal theory, together now show that animal movement (running, flying, swimming) and fluid eddy movement (turbulent structure) are both forms of optimized intermittent movement...
  78. ncbi The biophysics of asthmatic airway smooth muscle
    Newman L Stephens
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Ave, Winnipeg, MB, Canada R3E 3J7
    Respir Physiol Neurobiol 137:125-40. 2003
    ..Measurements also indicate that increased smooth muscle myosin light chain kinase content, via increased actomyosin ATPase activity could be responsible for the changes in contractility...
  79. ncbi Biophysics and clinical utility of irrigated-tip radiofrequency catheter ablation
    Mahmoud Houmsse
    Section of Electrophysiology, Division of Cardiovascular Medicine, Ross Heart Hospital, The Ohio State University, Columbus, USA
    Expert Rev Med Devices 9:59-70. 2012
    ..The purpose of this article is to review cooled-tip RF ablation biophysics and outcomes of clinical studies as well as to discuss future technological improvements.
  80. ncbi Time-resolved methods in biophysics. 7. Photon counting vs. analog time-resolved singlet oxygen phosphorescence detection
    Ana Jiménez-Banzo
    Grup d Enginyeria Molecular, Institut Quimic de Sarria, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain
    Photochem Photobiol Sci 7:1003-10. 2008
    ..Principles underlying this novel approach and selected examples of applications are provided in this perspective, which illustrate the advantages over the conventional analog detection mode...
  81. pmc Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy
    Haruto Ishikawa
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:16116-21. 2007
    ..The results may also provide some insights into the nature of the energy landscape in the vicinity of the folded protein free energy minimum...
  82. ncbi A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine
    Ping Liao
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    J Biol Chem 282:35133-42. 2007
    ..8 mM Ca(2+) external solutions. This is the first time that a smooth muscle Ca(v)1.2 splice variant has been identified functionally to possess biophysical property that can be linked to enhanced state-dependent block by DHP...
  83. ncbi Role of glutamate autoreceptors at hippocampal mossy fiber synapses
    Hyung Bae Kwon
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 60:1082-94. 2008
    ..Thus, negative feedback via presynaptic mGluRs is the dominant mode of glutamatergic autoregulation at the mf-CA3 synapse...
  84. ncbi From biophysics to cognition: reward-dependent adaptive choice behavior
    Alireza Soltani
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Opin Neurobiol 18:209-16. 2008
    ..This review focuses on recent studies of reward-based decision-making that have begun to tackle this challenge...
  85. ncbi Phase diagrams of quasispecies theory with recombination and horizontal gene transfer
    J M Park
    Department of Physics and Astronomy and Department of Bioengineering, Rice University, Houston, Texas 77005 1892, USA
    Phys Rev Lett 98:058101. 2007
    ..We show how transfer of genetic information changes the phase diagram and mean fitness and introduces metastability in quasispecies theory, via an analytic field theoretic mapping...
  86. ncbi Foreword: lipid rafts/biophysics, cell signalling, trafficking and processing
    Nigel M Hooper
    Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK
    Mol Membr Biol 23:1-3. 2006
  87. pmc Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1
    Joyce Wondolowski
    Department of Behavioral Neuroscience and Neuroscience Graduate Program, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 29:563-74. 2009
    ..GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms...
  88. ncbi From biophysics to behavior: Catacomb2 and the design of biologically-plausible models for spatial navigation
    Robert C Cannon
    Theoretical Neurobiology, Born Bunge Foundation, University of Antwerp, Universiteitsplein I, Antwerp, Belgium
    Neuroinformatics 1:3-42. 2003
    ....
  89. pmc Functional consequences of animal-to-animal variation in circuit parameters
    Jean Marc Goaillard
    Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts, USA
    Nat Neurosci 12:1424-30. 2009
    ..These data illustrate the importance of making multidimensional measurements from single preparations for understanding how variability in circuit output is related to the variability of multiple circuit parameters...
  90. ncbi The Bax pore in liposomes, Biophysics
    P H Schlesinger
    Department of Physiology and Cell Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Death Differ 13:1403-8. 2006
    ..Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers...
  91. ncbi Functional properties of the surface of the vermilion border of the lips are distinct from those of the facial skin
    H Kobayashi
    Department of Dermatology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai 980 8574, Japan
    Br J Dermatol 150:563-7. 2004
    ..Despite its prominent presence on the face, constituting not only the target of cosmetics but also the site for various skin diseases, its functional properties remain almost unknown...
  92. pmc Physical constraints and functional characteristics of transcription factor-DNA interaction
    Ulrich Gerland
    Department of Physics, University of California at San Diego, La Jolla, CA 92093 0319, USA
    Proc Natl Acad Sci U S A 99:12015-20. 2002
    ..We suggest further experiments to test whether this is a general feature for a large class of TFs...
  93. pmc Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site
    M Chahine
    Laval Hospital, Research Center, Ste Foy, Quebec, G1V 4G5 Canada
    Biophys J 75:236-46. 1998
    ..3-fold increase in affinity). Furthermore, substitution at Asp730 with cysteine and exposure to Cd2+ or methanethiosulfonate reagents had no significant effect on sodium currents, consistent with this residue not contributing to the pore...
  94. ncbi Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects
    Xuefei Ma
    Departments of Physiology and Surgery, Faculty of Medicine, University of Manitoba, Manitoba, Winnipeg R3E 3J7, Canada
    Am J Physiol Lung Cell Mol Physiol 283:L1181-9. 2002
    ..04 +/- 0.008, n = 11; P < 0.05). Messages for myosin heavy chain isoforms showed no difference. Increased kinase message content is an index of the mechanism for the increased velocity and capacity of shortening we report...
  95. ncbi Biophysics of nonablative dermal remodeling
    E Victor Ross
    Dermatology Department, Naval Medical Center San Diego, San Diego, CA 92134, USA
    Semin Cutan Med Surg 21:251-65. 2002
    ..The article is divided into a discussion of the physics of laser-tissue interactions, followed by a review of the types of devices used for nonablative skin remodeling, and the histologic findings that follow treatment...
  96. pmc A mechanistic model of the actin cycle
    M Bindschadler
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 86:2720-39. 2004
    ..This limitation arises because as the cycle becomes more dynamic, it tends toward the unpolymerized state...
  97. pmc A novel extended Granger Causal Model approach demonstrates brain hemispheric differences during face recognition learning
    Tian Ge
    Centre for Computational Systems Biology, Fudan University, Shanghai, People s Republic of China
    PLoS Comput Biol 5:e1000570. 2009
    ..The results provide the first evidence for connectivity changes between and within left and right inferotemporal cortexes as a result of face recognition learning...
  98. ncbi Biophysics of cardiopulmonary resuscitation with periodic z-axis acceleration or abdominal compression at aortic resonant frequencies
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University, 1426 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 69:455-69. 2006
    ..The method is able to sustain blood flow and long-term survival during and after prolonged cardiac arrest in anesthetized pigs. However, the exact mechanism by which circulation of blood is created has remained unknown...
  99. pmc Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water
    Minfen Li
    Department of Biological Sciences, Faculty of Science, Yong Loo Lin School of Mediciine, National Univeristy of Singapore, Singapore
    Biophys J 91:4201-9. 2006
    ..Our discovery not only gives a novel insight into the properties of insoluble proteins, but also sheds the first light that we know of on previously unknown regimes associated with proteins...
  100. ncbi Molecular structure of amyloid fibrils: insights from solid-state NMR
    Robert Tycko
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0520, USA
    Q Rev Biophys 39:1-55. 2006
    ....
  101. pmc Mechanics, malignancy, and metastasis: the force journey of a tumor cell
    Sanjay Kumar
    Department of Bioengineering, University of California, Berkeley, USA
    Cancer Metastasis Rev 28:113-27. 2009
    ....

Research Grants73

  1. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..This conference brings together scientists working in diverse disciplines including biophysics, structural, cell and molecular biology, drug development, and diverse clinical disciplines that are impacted by ..
  2. Effects of environmental thyroid hormone disrupting compounds on CNS development
    CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2013
    ..Ardem Patapoutian, a TSRI faculty member with expertise in biophysics of the TRPA1 channels, which the candidate will use to manipulate neuronal activity...
  3. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    This proposal is for the second competitive renewal of grant HL62969, focusing on the biophysics of nitrosyl heme chemistry and its role in nitric oxide (NO) signaling...
  4. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ....
  5. Fast accurate ultrasensitive in vitro assay to determine BoNT potency &stability
    ARMIN H REITMAIR; Fiscal Year: 2012
    ..quantitative, ultrasensitive and -specific biodetection technology, developed at the UCLA Single Molecule Biophysics Lab (headed by Prof...
  6. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2012
    ..We aim to investigate the genetics and the biophysics of T cell receptor clustering and pattern...
  7. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..We will further uncover the mechanisms underlying activation of ANO1s by RyR2s with 3D imaging, channel biophysics and reaction-diffusion modeling (Aim 2)...
  8. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..faculties in Section 2 (Development and Plasticity) focus on cell specification, retinal axon guidance, and biophysics and plasticity of dendrites and cortical circuitry, and are in the departments of Genetics, Pathology and Cell ..
  9. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
    ..technology with exquisite single well multiplexing potential, which was developed at the UCLA Single Molecule Biophysics Lab (headed by Prof. Shimon Weiss)...
  10. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2013
    ..of the molecular basis for electrical signaling is a major challenge for molecular biology and membrane biophysics. Previous studies supported by this research grant led to purification and reconstitution of the Na channel ..
  11. Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitability
    Peter J Mohler; Fiscal Year: 2013
    ..Our recent findings support a new basis for arrhythmia based not on mutations which affect channel biophysics, but instead on mutations to proteins which are required for proper expression and local regulation of ion ..
  12. Bioengineering of Novel Synthetic Lipid-Peptide Lung Surfactants
    Robert H Notter; Fiscal Year: 2013
    ..Aims 1 and 2 study the bioengineering, proteomics, synthesis, purification, molecular biophysics, and scale-up of synthetic peptides/lipopeptides and novel RL compounds based on promising preliminary data on ..
  13. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2013
    ..The proposed work determines the biophysics of interactions between antiviral polyamides (PAs) and their viral DNA targets, in order to determine the ..
  14. MOLECULAR PROPERTIES OF IONIC PERMEABILITY IN NERVE
    Bertil Hille; Fiscal Year: 2013
    ..The methodology will involve single-cell biophysics, electrophysiology, fluorescence resonance energy transfer, photometry, molecular biology, and confocal ..
  15. 2011 Nucleic Acids Gordon Research Conference
    Christopher D Lima; Fiscal Year: 2011
    ..eight broadly classified areas of nucleic acids research that encompass DNA and RNA biology, biochemistry and biophysics with a view toward highlighting emerging concepts and technologies in these fields...
  16. Nuclear ryanodine receptor type 1: Role in skeletal muscle physiology and disease
    Viktor Yarotskyy; Fiscal Year: 2013
    ..The applicant has outstanding skills and great expertise in electrophysiology and biophysics, but lacks essential in-depth training in other key components required for a successful independent career in ..
  17. Aberrant activation of HGF/MET signaling as a therapeutic target in AML
    Alex Kentsis; Fiscal Year: 2013
    ..the Dana-Farber Cancer Institute (DFCI) has outlined a 5-year career plan that will build upon his background in biophysics and clinical hematology/oncology. Under the mentorship of Dr...
  18. Photocleavable Bead Technology for Glycomics
    Mark Lim; Fiscal Year: 2013
    ..Center for Biomedical Mass Spectrometry, President, Human Proteome Organization, and Professor, Biochemistry, Biophysics and Chemistry who is a recognized expert in mass spectrometry based glycomics techniques (see letters of ..
  19. INTRACOCHLEAR ELECTROCHEMICAL GRADIENTS
    Alexander A Spector; Fiscal Year: 2012
    ..Molecular and cellular biology, bioinformatics, biophysics, neuroscience, chemical physics, and bioengineering approaches will all be used...
  20. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..These electrical gradients are highly relevant to the outcomes of cardiac defibrillation and resuscitation of individuals who have experienced sudden cardiac arrest. ..
  21. Computational and Cell Culture Models for Mucus Clearance
    Richard Superfine; Fiscal Year: 2010
    ..By combining a team of researchers from Applied Mathematics, Physics, Biochemistry and Biophysics, and the UNC Cystic Fibrosis Center, the goal of this project is to develop cell-based biophysical assays that ..
  22. Scripps Translational Science Institute (TL1)
    ERIC JEFFREY TOPOL; Fiscal Year: 2013
    ..While there are core curricular tracks in Chemistry, Chemical Biology, Biology, Biophysics and Immunology that serve as pre-defined exemplars, the tradition at TSRI is to customize the curriculum for ..
  23. CRCNS: Theory and experiment of neural circuit mapping by DNA sequencing
    Anthony M Zador; Fiscal Year: 2013
    ..Second, we will build descriptive models for biophysics and combinatorics of DNA recombination that can be used in neuroscience and beyond...
  24. 2010 and 2012 Membrane Transport Proteins
    Robert H Edwards; Fiscal Year: 2012
    ..In addition, the speakers will describe a diversity of techniques and approaches, from structural biology and biophysics to animal models and genetics...
  25. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..Our studies combine expertise from neurophysiology, psychology and biophysics in order to gain a basic understanding of the challenges wearers of bilateral implants face in everyday ..
  26. HORMONES: BIOCHEMISTRY AND MOLECULAR BIOLOGY
    MAX ELLIOT GOTTESMAN; Fiscal Year: 2013
    ..The participating Departments are Anatomy and Cell Biology, Biochemistry and Molecular Biophysics, Endocrinology, Genetics and Development, Medicine, Microbiology, Pathology, Pediatrics and Pharmacology as well ..
  27. M tuberculosis Membrane Protein Pharmaceutical Targets
    Timothy A Cross; Fiscal Year: 2013
    ..knowledge of: Mycobacterium tuberculosis, essential Mtb genes, membrane protein physiology, molecular biology, biophysics, and structural characterization...
  28. RAGE Mediated Mechanisms of Islet Amyloid Polypeptide Cytotoxicity in Type 2 Diab
    Andisheh Abedini; Fiscal Year: 2011
    ..We have recruited the assistance of a world leader in amylin biophysics to assist us and help guide my studies. My preliminary data show that h-amylin binds RAGE in vitro...
  29. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2009
    ..proposal will support the training of a graduate student in important areas of modern protein chemistry, biophysics and enzymology, and form the basis of their Ph.D. thesis...
  30. Leica TCS SP5 Multiphoton Confocal Microscope
    Heather A Drummond; Fiscal Year: 2012
    ..been supported by institutional resources and by the Program Project Grant in the Department of Physiology and Biophysics (PO1 HL051971-18)...
  31. Design and Implementation of Genetically Encoded Myosin Based Force Sensors
    DANIEL PETER KIEHART; Fiscal Year: 2013
    ..Major advances have improved our understanding of the biophysics of chemomechanical force production by motor proteins in vitro...
  32. Multiplex ALEX-based Test for Protease Activity Profiling in Arthritic Joints
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..quantitative, ultrasensitive and -specific biodetection technology, developed at the UCLA Single Molecule Biophysics Lab (headed by Prof...
  33. Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart
    Ranjan K Dash; Fiscal Year: 2013
    ..The overall goal of this collaborative proposal is therefore to quantify the biophysics and chemical kinetics associated with mitochondrial handling of pH, cations, and ROS in cardiomyocytes and to ..
  34. Structural Dynamics of Cardiac Muscle Contraction
    Brett A Colson; Fiscal Year: 2012
    ..goal of this project is to prepare the applicant for a career as an independent investigator in molecular biophysics of muscle, with particular emphasis on the heart...
  35. The role of tumor suppressor Rb in horizontal neuron development
    Michael A Dyer; Fiscal Year: 2011
    ..This research will be done primarily in Brazil, at the Biophysics Institute of the Federal University of Rio de Janeiro (IBCCF/UFRJ) in collaboration with Dr...
  36. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2013
    ..Insight into the roles of E. coli osmolytes (e.g. Kglutamate, glycine betaine) in the biophysics of regulation of cytoplasmic volume and biopolymer volume fraction in response to osmotic stress will be ..
  37. ANESTHESIOLOGY RESEARCH TRAINING
    Charles W Emala; Fiscal Year: 2013
    ..as well as from nine collaborating departments, four in basic sciences: Pharmacology, Physiology and Cellular Biophysics, Pathology and Cell Biology, and the multidisciplinary Center for Neurobiology and Behaivor;and five clinical ..
  38. Deciphering the Mechanism of Transporters by Design and Experiments
    HYUN JOONG CHO; Fiscal Year: 2013
    ..metal- and sugar-transportation as model systems, using methods of experimental, computational and struc- tural biophysics. In implementing the work, my expertise in membrane protein structure and thermodynamic folding will be ..
  39. Automated Analysis of Learning and Memory for Neuro-Developmental Studies
    Michael Levin; Fiscal Year: 2010
    ..provided by applicant): Xenopus laevis is an extremely powerful system in which to study the genetics and biophysics of developmental morphogenesis...
  40. Reading the histone code:nanoscale morphology of Epigneomic Histone Modifications
    M Mitchell Smith; Fiscal Year: 2010
    ..This project will exploit breakthroughs in fluorescent light microscopy, and recent insights into the biophysics of the modifications, to develop technology that will enable researchers to see the structures of these ..
  41. Genetic Elucidation of VTA Glutamate Neurons
    THOMAS HNASKO; Fiscal Year: 2013
    ..Robert Edwards. Robert is a world-renowned investigator at the forefront of vesicular transporter biophysics and cell biology...
  42. MITOCHONDRIAL CA2+ TRANSPORT IN HEART CELLS
    Shey Shing Sheu; Fiscal Year: 2010
    ..with our collaborators, we will use multidisciplinary approaches encompassing cell biology, biochemistry, biophysics, and molecular biology, to elucidate the molecular and functional characteristicsof mitochondrial Ca2+ influx ..
  43. TRAINING IN BIOMOLECULAR PHARMACOLOGY
    David H Farb; Fiscal Year: 2013
    ..of Anatomy &Neurobiology, Biochemistry, Biology, Chemistry, Medicine, Neurology, Pathology, Physiology and Biophysics, Psychiatry, and Psychology...
  44. Center for Reproductive Research at Northwestern University
    Teresa K Woodruff; Fiscal Year: 2012
    ..of basic biological, biochemical and biophysical findings to clinical care by bringing experts in engineering, biophysics and structural biology together with reproductive endocrinologists and clinical investigators...
  45. Epilepsy Training Grant
    John R Huguenard; Fiscal Year: 2013
    ..The faculties employ the methods of cellular neurophysiology and biophysics, live imaging, biochemistry, molecular biology, neuroanatomy, neuropharmacology, and the use of animal model ..
  46. TRAINING PROGRAM IN ENDOCRINOLOGY AND METABOLISM
    John P Bilezikian; Fiscal Year: 2013
    ..extend opportunities for endocrinology training to laboratories in the Departments of Physiology and Biophysics, Genetics and Development, Pediatrics, Microbiology, Anatomy and Cell Biology, Pharmacology, and Nutrition...
  47. Stanford Center for Clinical and Translational Education and Research (SCCTER)TL1
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..are available across the University in the School of Humanities and Science (Biological Sciences and Biophysics), the School of Engineering (Bioengineering, Biomedical Informatics, and Biomechanical Engineering), the ..
  48. Understanding The Structural Basis of APOBEC Functions
    Xiaojiang S Chen; Fiscal Year: 2012
    ..deaminase family, with focuses on APOBEC3G and 3F (Apo3G and 3F) proteins and their interactions with cellular and viral ligands, using mainly structural biology, assisted by biophysics, molecular biology, and functional biochemistry.
  49. Harnessing mechanical signals to control mesenchymal stem cell fate
    JANET E RUBIN; Fiscal Year: 2013
    ..In sum, this BRP lies at the convergence of engineering, molecular biology, biophysics and medicine to understand how mechanical signals regulate MSC cell fate, with the ultimate goal of harnessing ..
  50. Biacore T100 SPR system for studying and characterizing biomolecular interaction
    Ewa Folta Stogniew; Fiscal Year: 2009
    ..The requested instrument and service will replace the old system and will be located in a core facility, the Biophysics Resource of Keck Laboratory, and will be available to anyone needing application of SPR in his or her research...
  51. ANESTHETIC-INDUCED CARDIAC PRECONDITIONING
    Zeljko J Bosnjak; Fiscal Year: 2012
    ..a comprehensive effort to leverage our existing infrastructure and programmatic experience in physiology, biophysics, genomics, proteomics, and computational biology to advance our understanding of the cellular and subcellular ..
  52. Synthesis and properties of a bacterial bioadhesive
    Yves V Brun; Fiscal Year: 2013
    ..The general goal of this research is to use a multidisciplinary approach ranging from genetics to biophysics to study the chemical and biophysical basis for holdfast properties and to understand how holdfast properties ..
  53. Cyclotron for PET Radiopharmaceuticals
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..Departments of Radiological Sciences, Psychiatry and Human Behavior, Pharmacology, Physiology and Biophysics, Surgery, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Orthopedic ..
  54. Structural and functional effects of oxidative modification of myosin
    REBECCA J MOEN; Fiscal Year: 2013
    ..of the training program are (a) to provide me with extensive training in muscle biochemistry, physiology, and biophysics, toward completion of a PhD thesis in the molecular biophysics of muscle protein oxidation, and (b) to prepare ..
  55. Biological Mechanism of FSGS-1
    Martin R Pollak; Fiscal Year: 2011
    ..2. Define the relationship between Actn4-mediated in vitro cytoskeletal biophysics and the biophysical behavior of cells...
  56. Kidney Disease and Inflammation
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..Medicine, Pediatrics, Pharmacology, Microbiology, Pathology, Biomedical Engineering, Molecular Physiology and Biophysics, the Cardiovascular Research Center, Center for Cell Signaling, Beirne Carter Center of Immunology and Public ..
  57. Short-Term Research Training: Students in Health Professional Schools
    John N Forrest; Fiscal Year: 2013
    ..hematology, infectious disease, nephrology, pulmonary, rheumatology), laboratory medicine, molecular biophysics and biochemistry, molecular, cellular &developmental biology, neurology, neurosurgery, obstetrics &..
  58. REQUEST TO PURCHASE A 600 MHZ NMR REPLACEMENT CONSOLE AND COLD PROBE
    Joseph J H Ackerman; Fiscal Year: 2013
    ..that serves 40 separate research groups, spanning departments of Anesthesiology, Biochemistry &Molecular Biophysics, Biology, Biomedical Engineering, Cardiology, Chemistry, Infectious Diseases, Internal Medicine, Neurology, ..
  59. Training Grant in Renal Function and Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..Program faculty provide access to training in methodologies aligned with translational research such as biophysics, renal cell biology, proteomics, high-end microscopy, animal models of renal diseases, and clinical trials...
  60. KATP channel regulation of bodily energy expenditure and weight maintenance
    Leonid Zingman; Fiscal Year: 2012
    ..The applicant has a background in clinical pharmacology, electrophysiology and biophysics acquired through previous training, but requires additional theory and methodology in molecular biology, gene ..
  61. The Structure and Function of the Influenza Virus Genome
    Robert A Lamb; Fiscal Year: 2013
    ..influenza virus budding in vitro and in vivo using assays that are well established in the field of membrane biophysics but are under utilized in the field of virology and that we have developed in our laboratory...
  62. Structure and Function of CaM-Kinase II
    M Neal Waxham; Fiscal Year: 2012
    ..thought to coordinate and regulate the formation and modification of synaptic connections and our goals are to understand how this happens using a variety of modern techniques such as structural biology, protein chemistry and biophysics.
  63. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..of faculty members from Pediatric Nephrology, Biostatistics, Anatomy/Neural Sciences, and Biochemistry/Molecular Biophysics engaged in the following areas of research: molecular mechanisms of injury and repair of progressive renal ..
  64. STRUCTURES OF RNA BINDING PROTEINS FROM INFLUENZA VIRUS
    Gaetano Montelione; Fiscal Year: 2000
    ..This is a long-term project combining expertise in moleculr biology, molecular biophysics, and modern NMR spectroscopy...
  65. Biophysics of Acupuncture: Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2009
    ..tissue, to study acupuncture's effect on these electrical properties, and to study the underlying biophysics to identify any clinically relevant mechanisms...
  66. TRAINING GRANT IN MOLECULAR BIOPHYSICS
    WILMA OLSON; Fiscal Year: 2003
    Funding is requested for continued support of an interdisciplinary training program in molecular biophysics at Rutgers University...
  67. Purchase of Analytical Ultracentrifuge for Molecular Biophysics at Florida State
    TIMOTHY LOGAN; Fiscal Year: 2007
    ..be housed in the Physical Biochemistry Facility, a centralized facility located in the Institute of Molecular Biophysics, that serves faculty, students, and postdoctoral associates in the Departments of Chemistry and Biochemistry, ..
  68. Real-time Single-Molecule Analysis for Transient Molec. Complex Characterization
    Taiho Kim; Fiscal Year: 2009
    ..It was pioneered at the UCLA Single Molecule Biophysics Lab, which is headed by Prof. Shimon Weiss...
  69. 2009 Antigen Cross Presentation Gordon-sponsored Meeting
    Stephen Schoenberger; Fiscal Year: 2009
    ..several scientific fields, including: Cell Biology;Cell Death;Dendritic Cell Immunobiology;Protein Folding;Lipid Biophysics;Signal Transduction;Antigen Processing and Presentation;and Translational Research including Tumor Immunology, ..
  70. Upgrade of GE 3.0T SIGNA MRI Scanner for Enhanced Neuroimaging
    James S Hyde; Fiscal Year: 2010
    ..James S. Hyde, Ph.D., Professor of Biophysics at the Medical College of Wisconsin (MCW) was PI of that proposal and serves again as PI of this proposal...
  71. BIOPHYSICS OF SICKLE CELL/ENDOTHELIAL CELL ADHERENCE
    TIMOTHY WICK; Fiscal Year: 2000
    ..We hypothesize that in vivo, adherence biophysics (primarily strength) will regulate the extent of sickle cell adhesion and vaso-occlusion...
  72. Biophysics Cell Membrane Probe
    William E Brownell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): A Biophysics Cell Membrane Probe (BCMProbe) is requested to expand biophysical studies on the membranes of living cells...
  73. International School of Biophysics: Transporters and Channels
    LOUIS DE FELICE; Fiscal Year: 2005
    We are requesting support for an International School of Biophysics on the topic of "Transporters and Channels" to be held in Erice, Sicily from May 31 to 6 June 2005, and a continuation conference on the same topic to be held in the US ..