Genomes and Genes
herb drug interactions
Summary: The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
Publications224 found, 100 shown here
- Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humansBill J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
Clin Pharmacol Ther 72:276-87. 2002..Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of St John's wort, garlic oil, Panax ginseng, and Ginkgo biloba affected CYP1A2, CYP2D6, CYP2E1, or CYP3A4 activity...
- [Herbal medicines--evidence and drug interactions in clinical practice]Thomas Klint Kistorp
Amtssygehuset i Gentofte, Anaestesiologisk afdeling, H S Frederiksberg Hospital, anaestesiklinikken
Ugeskr Laeger 164:4161-5. 2002..Physicians should be aware of and report potential drug interactions and adverse effects, so as to throw more light on this subject...
- St John's wort: a systematic review of adverse effects and drug interactions for the consultation psychiatristPaul Hammerness
Harvard Medical School, Boston, Massachusetts, USA
Psychosomatics 44:271-82. 2003..This evidence-based presentation of the literature includes a brief description of pharmacodynamics and clinical applications, followed by a systematic review of adverse effects, toxicity, and drug interactions...
- Panax ginsengDavid Kiefer
Program in Integrative Medicine, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
Am Fam Physician 68:1539-42. 2003..Panax ginseng does not appear to enhance physical performance. Products with a standardized ginsenoside concentration are available...
- Community identification of natural health product-drug interactionsTheresa L Charrois
CARE Program, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Ann Pharmacother 41:1124-9. 2007..Community pharmacists regularly field inquiries regarding NHPs. As such, pharmacists are ideally placed to answer questions about NHP use and interactions with other medications...
- Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein)Serena Marchetti
The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Oncologist 12:927-41. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- St Johns wort increases expression of P-glycoprotein: implications for drug interactionsMartina Hennessy
Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James s Hospital, Trinity College, Dublin 8, Ireland, UK
Br J Clin Pharmacol 53:75-82. 2002....
- Potential interactions between alternative therapies and warfarinA M Heck
School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA
Am J Health Syst Pharm 57:1221-7; quiz 1228-30. 2000..Pharmacists and other health care professionals should question all patients about use of alternative therapies and report documented interactions to FDA's MedWatch program...
- Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goatsMadhukar S Dama
Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agricultural University, Palampur 176 062, Himachal Pradesh, India
J Vet Sci 9:25-9. 2008..21 mg/kg is required to be administered at 8 h intervals. For practical purposes in goats this would mean a priming dose of 6 mg/kg and a maintenance dose of 2 mg/kg given by the oral route, to be repeated at 8 h intervals...
- Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodiumL G Lala
Department of Pharmacognosy and Phytochemistry, Prin K M Kundnani College of Pharmacy, Dr R G Thadani Marg, Worli, Mumbai 400 018, India
J Ethnopharmacol 91:277-80. 2004..Thus, the experimental findings indicated that Trikatu pretreatment might decrease the bioavailability of certain drugs probably through a drug-herb interaction thereby adversely affecting the therapeutic efficacy of these drugs...
- Interactions between herbal medicines and prescribed drugs: a systematic reviewA A Izzo
Department of Experimental Pharmacology, University of Naples 'Federico II, Naples, Italy
Drugs 61:2163-75. 2001..Healthcare professionals should ask their patients about the use of herbal products and consider the possibility of herb-drug interactions...
- Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hensM Singh
Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agricultural University, Himachal Pradesh, India
J Vet Sci 6:197-200. 2005..The total body clearance (Cl(B)) reduced by 21%whereas total duration of pharmacological effect (t(d)) increased by 29%. The treatment with P. longum reduced loading and maintenance dose by 33.3 and 39%, respectively...
- Perioperative herbal supplement use in cancer patients: potential implications and recommendations for presurgical screeningNagi B Kumar
Department of Nutrition, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
Cancer Control 12:149-57. 2005..The use of herbal supplements by cancer patients in the perioperative period is common and consistent with the substantial increase in the use of alternative medical therapies...
- St John's wort (Hypericum perforatum): drug interactions and clinical outcomesL Henderson
Pharmacovigilance Group, Medicines Control Agency, UK
Br J Clin Pharmacol 54:349-56. 2002..The aim of this work is to identify the medicines which interact with the herbal remedy St John's wort (SJW), and the mechanisms responsible...
- Herbal hepatotoxicityLeonard B Seeff
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 31 Center Drive, Room 9A27, Bethesda, MD 20892, USA
Clin Liver Dis 11:577-96, vii. 2007..Although many of them are clearly implicated, there are some, particularly those identified solely through an occasional case report, for which the relationship is uncertain...
- An examination of the bleeding complications associated with herbal supplements, antiplatelet and anticoagulant medicationsA E Spolarich
Arizona School of Dentistry and Oral Health, USA
J Dent Hyg 81:67. 2007....
- Lack of pharmacokinetic interaction between St. John's wort and prednisoneEdward C Bell
College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
Ann Pharmacother 41:1819-24. 2007..The supplement has been shown to affect the metabolism of various CYP3A4 substrates. The CYP3A4 pathway mediates the metabolism of a large number of drug entities, including the corticosteroids prednisone and prednisolone...
- Herbal medicine and epilepsy: proconvulsive effects and interactions with antiepileptic drugsNoah Samuels
The Center for Integrative Complementary Medicine, Shaare Zadek Medical Center, Jerusalem, Israel
Epilepsia 49:373-80. 2008..At the same time, further research is required regarding the effect of herbs on seizure activity and interactions with AED treatment...
- Potential interactions between complementary/alternative products and conventional medicines in a Medicare populationGary W Elmer
Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
Ann Pharmacother 41:1617-24. 2007..Despite the high prevalence of complementary and alternative medicine (CAM) product use among the elderly, little is known about the extent of concurrent CAM-conventional medicine use and the potential for adverse reactions...
- Herbal supplements in older adults. Consider interactions and adverse events that may result from supplement useJennifer C Hoblyn
Palo Alto Veterans Affairs Health Care System, California, USA
Geriatrics 60:18, 22-3. 2005
- Pharmacokinetic interactions of drugs with St John's wortShufeng Zhou
Department of Pharmacy, Faculty of Science, National University of Singapore
J Psychopharmacol 18:262-76. 2004..Because the potential interaction of St John's wort with other drugs is a major safety concern, additional systematic research on herb-drug interactions and appropriate regulation in herbal safety and efficacy is needed...
- Herbal supplements and therapeutic drug monitoring: focus on digoxin immunoassays and interactions with St. John's wortAmitava Dasgupta
Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
Ther Drug Monit 30:212-7. 2008..John's wort. Understanding the effect of herbal products on TDM methodologies and identification of interactions between herbal products and drugs by TDM are very important clinically...
- Complementary and alternative interventions in asthma, allergy, and immunologyLeonard Bielory
Department of Medicine, Pediatrics, and Ophthalmology, Division of Allergy, Immunology, and Rheumatology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
Ann Allergy Asthma Immunol 93:S45-54. 2004..To review which herbs are most commonly used as complementary and alternative medicine (CAM) for treatment of asthma, allergy, and immunologic conditions...
- Herbal medications in the perioperative orthopedic surgery patientPhilip Trapskin
University of Kentucky Chandler Medical Center, Lexington, KY 40536, USA
Orthopedics 27:819-22. 2004
- Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?Veronika Butterweck
Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
Planta Med 70:784-91. 2004..Efforts to identify all possible interactions will lead to limitless investigations and to inconsistent decisions...
- The case of the felonious foxglove: the dark side of natural curesMarjorie K Jeffcoat
J Am Dent Assoc 135:1218, 1220. 2004
- [Potential risks, adverse effects and drug interactions associated with herbal medicine in dental patients]A Zlotogorski Hurvitz
Dept of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschlager School of Dental Medicine, Tel Aviv University, Tel Aviv
Refuat Hapeh Vehashinayim 21:25-41, 97. 2004..The purpose of this article was to review the literature on the potential risks of commonly used herbal medications: Ginkgo Biloba, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, Garlic, Kava and Ephedra...
- The effect of herbal medicines on platelet function: an in vivo experiment and review of the literatureBenjamin W Beckert
Division of Plastic Surgery and Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO 65201, USA
Plast Reconstr Surg 120:2044-50. 2007....
- Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interactionAngelo A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
Int J Cardiol 98:1-14. 2005..John's wort. Interaction between herbal medicine and cardiovascular drugs is a potentially important safety issue. Patients taking anticoagulants are at the highest risk...
- Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo bilobaBill J Gurley
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Drugs Aging 22:525-39. 2005....
- Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysisStephen Shalansky
Pharmacy Department, Vancouver Coastal Health Providence Health Care Pharmacy Services, Vancouver, British Columbia, Canada
Pharmacotherapy 27:1237-47. 2007..To determine the risk of bleeding and supratherapeutic international normalized ratios (INRs) associated with use of complementary and alternative medicine (CAM) in patients receiving warfarin...
- Safety of St. John's Wort extract compared to synthetic antidepressantsV Schulz
Phytomedicine 13:199-204. 2006..However, such cases are extremely rare and, with medical supervision, easily avoided. In conclusion, the safety of SWE must be considered more favourable than that of synthetic antidepressants...
- Herbs and dietary supplement use in patients with stage 5 chronic kidney diseaseJerrilynn D Burrowes
Long Island University, Department of Nutrition, School of Health Professions and Nursing, Brookville, NY, USA
Nephrol Nurs J 33:85-8. 2006..Information on the use, safety, efficacy, adverse effects, and recommended dosages in the nondialysis population are summarized in this article...
- Use of herbal supplements and vitamins in plastic surgery: a practical reviewGeorge Broughton
Department of Plastic Surgery, Nancy L and Perry Bass Advanced Wound Healing Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9132, USA
Plast Reconstr Surg 119:48e-66e. 2007..4. Explain the preoperative management of patients using herbal supplements. 5. Know additional resources to consult when unanswered questions arise...
- Herbal product-drug interactions mediated by inductionRommel G Tirona
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
Br J Clin Pharmacol 61:677-81. 2006..This type of interaction is likely to be relevant to other herbal products. Caregivers need to be aware of the issues and options for therapeutic management...
- Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?Heike Gutmann
Department of Clinical Pharmacology and Toxicology, University Clinic Basel, Basel, Switzerland
Planta Med 72:685-90. 2006..These effects could be mimicked by "artificial extracts" containing the same compositions of hyperforin, hypericin and quercitrin as the plant extracts...
- [Anaesthetic preoperative assessment of chronic medications and herbal medicine use: a multicenter survey]C Baillard
Départements d anesthésie réanimation, CHU Avicenne, EA 3409, 93009 Bobigny, France
Ann Fr Anesth Reanim 26:132-5. 2007..This study was undertaken to quantify the use of chronic medication and herbal remedies in the presurgical population...
- Herbal supplements: Facts and myths--talking to your patients about herbal supplementsBarbara Ann M Messina
School of Nursing, State University of New York at Stony Brook, Stony Brook, NY 11794 8240, USA
J Perianesth Nurs 21:268-78; quiz 279-81. 2006....
- Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trialA Portoles
Clinical Pharmacology Studies Unit, Clinical Pharmacology Service, Hospital Clinico San Carlos, Madrid, Spain
J Clin Pharmacol 46:1188-94. 2006..3 +/- 25.1 ng x h/mL, P < .01). Tendencies toward shorter time to C(max) and lower apparent terminal half-life values were found. Pharmacokinetic results are consistent with an induction of ivabradine metabolism by H perforatum...
- Unregulated herbal products: potential interactions and side effects in dental patientsRoger E Alexander
Department of Oral and Maxillofacial Surgery, Baylor College of Dentistry, Texas A and M University Health Science Center, Dallas, USA
Tex Dent J 124:364-85. 2007
- Evolution of medical treatment for endometriosis: back to the roots?Fritz Wieser
Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, 1090 Vienna, Austria
Hum Reprod Update 13:487-99. 2007..We encourage the development of herbal analogues and establishment of special, simplified registration procedures for certain medicinal products, particularly herbal derivates with a long tradition of safe use...
- Interaction between a commercially available St. John's wort product (Movina) and atorvastatin in patients with hypercholesterolemiaL Andrén
Department of Medicine Clinical Pharmacology, Gothenburg University, Sahlgrenska University Hospital, Vita Stråket 11, S 413 45, Gothenburg, Sweden
Eur J Clin Pharmacol 63:913-6. 2007....
- Prediction of herb-drug metabolic interactions: a simulation studyShufeng Zhou
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
Phytother Res 19:464-71. 2005..However, many herb- and drug-related factors may cause difficulties with the prediction, and thus in vivo animal and human studies are always necessary...
- An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituentsAmy S Etheridge
Health Sciences Unit, Science and Engineering, RTI International, Research Triangle Park, NC 27709 2194, USA
Planta Med 73:731-41. 2007..The data suggest that the clearance of a variety of drugs may be diminished by concomitant use of these herbs via inhibition of P450 enzymes, but less so by Pgp-mediated effects...
- Herb digoxin interactionsTsung O Cheng
Int J Cardiol 110:93. 2006
- Ginseng and other herbal medicines that interact with warfarinTsung O Cheng
Int J Cardiol 104:227. 2005
- Natural health product-drug interactions: a systematic review of clinical trialsEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Ther Drug Monit 27:549-57. 2005..With the exception of St. John wort, clinicians and the public do not have information that permits strong inferences about interactions between NHPs and conventional medications...
- Complementary and alternative medicine (CAM) for the treatment of chronic hepatitis B and C: a reviewApurva A Modi
The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institute of Health, Bethesda, MD, USA
Antivir Ther 12:285-95. 2007..Five herbals used in the past to treat viral hepatitis are reviewed and evaluated for the quality of their studies and mention is made of herbals known to have adverse effects...
- [Natural remedies--self care at your own risk! Danger of unknown adverse effects and interactions with "common" medications]Curt Peterson
Universitetssjukhuset i Linköping
Lakartidningen 102:3200-1. 2005
- Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approachXuemin Jiang
Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
J Clin Pharmacol 46:1370-8. 2006..None of the herbs studied had a direct effect on warfarin pharmacodynamics. Studies in anticoagulated patients are warranted to assess the clinical significance of these herb-drug interactions...
- [Adverse drug effects and interactions. What is the current thinking about the use of St. John's wort?]Andreas Johne
Institut für Klinische Pharmakologie Universitätsklinikum Charité Humboldt Universität zu Berlin Schumannstr, 20 21 D 10098 Berlin
Pharm Unserer Zeit 32:242-6. 2003
- Toward optimal health: the experts discuss the use of botanicals by women. Interview by Jody Godfrey MeislerStacie E Geller
National Center of Excellence in Women s Health, University of Illinois, Chicago, IL, USA
J Womens Health (Larchmt) 12:847-52. 2003
- [Drug interactions caused by phytopharmaceuticals. Don't underestimate herbs!]Peter Stiefelhagen
MMW Fortschr Med 144:6-9. 2002
- Potential drug-herb interaction with antiplatelet/anticoagulant drugsJun Tze Saw
School of Pharmaceutical Sciences, University Science Malaysia, Minden, 11800 Penang, Malaysia
Complement Ther Clin Pract 12:236-41. 2006..It is thus prudent for all care givers to be aware of the possibility of drug-herb interaction and inquire about herbal use from patients...
- The use of herbs and complementary and alternative medicine in pediatric preoperative patientsYuan Chi Lin
Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Clin Anesth 16:4-6. 2004..To determine the use of herbs and complementary and alternative medicine among a pediatric preoperative population...
- Herbal therapiesRobert H Howland
University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
J Psychosoc Nurs Ment Health Serv 43:16-9. 2005
- Herbal medication: potential for adverse interactions with analgesic drugsW Abebe
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
J Clin Pharm Ther 27:391-401. 2002..However, as most of the interaction information available is based on individual case reports, animal studies and in vitro data, further research is needed to confirm and assess the clinical significance of these potential interactions...
- Herbal interactions with cardiovascular drugsDennis V C Awang
MediPlant Consulting Inc, White Rock, British Columbia, Canada
J Cardiovasc Nurs 16:64-70. 2002..This can be especially important for drugs with narrow therapeutic windows and in sensitive patient populations such as older adults, the chronically ill, and those with compromised immune systems...
- Herb-drug interactionsLisa Cranwell-Bruce
Byridine F Lewis School of Nursing, College of Health and Human Services, Georgia State University, Atlanta, GA, USA
Medsurg Nurs 17:52-4. 2008
- The emerging recognition of herb-drug interactions with a focus on St. John's wort (Hypericum perforatum)J S Markowitz
Department of Pharmaceutical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA
Psychopharmacol Bull 35:53-64. 2001..Concomitant use of herbal agents and conventional medications should generally be discouraged until further information is available. Additional research is urgently needed in this area...
- [Metabolic effects and drug interactions provoked by certain vegetables: grapefruit, St. John's wort and garlic]Maur Neuman
Presse Med 31:1416-22. 2002..GARLIC: (Allium salivum) Originating from Asia, widespread and cultivated in Europe in kitchen gardens, garlic is used by herbalists for its diuretic, antiseptic, stimulating and sudorific properties...
- Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?Michael Heinrich
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, United Kingdom
Planta Med 74:657-60. 2008..The available evidence points to weak cytochrome P450 inhibition which is unlikely to be of clinical relevance...
- Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidenceA A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
Int J Clin Pharmacol Ther 42:139-48. 2004..g. sertaline, paroxetine, nefazodone) or buspirone, SJW can cause serotonergic syndrome. SJW represents a herbal medicine with a high potential for drug interactions. Some of such interactions may have serious clinical consequences...
- Herb-drug interactionsA Fugh-Berman
George Washington University School of Medicine and Health Sciences, Department of Health Care Sciences, Washington, DC 20037, USA
Lancet 355:134-8. 2000..Many reports of herb-drug interactions are sketchy and lack laboratory analysis of suspect preparations. Health-care practitioners should caution patients against mixing herbs and pharmaceutical drugs...
- Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an updateShu Feng Zhou
Division of Pharmacy, School of Life Sciences, Faculty of Science, Queensland University of Technology, Brisbane, Queensland, Australia
Curr Drug Metab 8:526-53. 2007..Due to the wide use and easy availability of herbal medicines, further research should be conducted to ensure the safety and quality of herbal medicine...
- Herbal medicines and perioperative careM K Ang-Lee
Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
JAMA 286:208-16. 2001..Widespread use of herbal medications among the presurgical population may have a negative impact on perioperative patient care...
- A review of the use of CAM therapy and the sources of accurate and reliable informationMary McHughes
Department of Pharmacotherapy, College of Pharmacy, University of Utah, 30 South 2000 East Rm 258, Salt Lake City, UT 84112 5820, USA
J Manag Care Pharm 11:695-703. 2005....
- [Use of complementary and alternative medicine among the patients in primary health care]Tomislav Cizmesija
National Railroad Health Center, University of Zagreb, Zagreb, Croatia
Acta Med Croatica 62:15-22. 2008..Use of complementary and alternative medicine (CAM) is widespread in western countries despite its unconfirmed effectiveness. The aim of the study was to show the use of CAM by patients in primary health care...
- Herbal bioactivation: the good, the bad and the uglyShufeng Zhou
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543
Life Sci 74:935-68. 2004..The safety and quality of herbal medicine should be ensured through greater research, pharmacovigilance, greater regulatory control and better communication between patients and health professionals...
- Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitroXin Wang
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
Phytomedicine 17:868-75. 2010....
- [Oral anticoagulants: a literature review of herb-drug interactions or food-drug interactions]S Bourget
Département pharmacie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
J Pharm Belg 62:69-75. 2007..To identify herbal medicines and food products which can interact with anticoagulant therapy...
- Impact of traditional medicinal plant extracts on antiretroviral drug absorptionL Brown
Department of Pharmacy, University of Limpopo Medunsa Campus, P O Box 218, Ga Rankuwa 0204, South Africa
J Ethnopharmacol 119:588-92. 2008..Many patients infected with the human immunodeficiency virus are taking traditional herbal medicines in conjunction with their modern antiretroviral medication and drug-herb interactions can occur in these cases...
- Some commonly fed herbs and other functional foods in equine nutrition: a reviewCarey A Williams
Department of Animal Sciences, Equine Science Center, Rutgers, The State University of New Jersey, School of Environmental and Biological Sciences, New Brunswick, NJ 08901, USA
Vet J 178:21-31. 2008..Horses fed garlic at >0.2g/kg per day developed Heinz body anaemia. Drug-herb interactions are common and caution needs to be taken when implementing 'natural product' usage...
- A gap between acceptance and knowledge of herbal remedies by physicians: the need for educational interventionYuri N Clement
Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago
BMC Complement Altern Med 5:20. 2005....
- Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteersYao Chen
Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China
Ann Pharmacother 44:1038-45. 2010..Curcumin is a kind of plant polyphenol that is extracted from the rhizome of Curcuma longa. Studies about the effect of curcumin on the activity of drug-metabolizing enzymes in humans are lacking...
- 20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactionsJingwei Zhang
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu, 210009, People s Republic of China
Drug Metab Dispos 38:2179-87. 2010..It could increase the absorption of P-gp substrate drugs without long-term induction of P-gp expression in rats...
- Cardiovascular adverse effects of herbal medicines: a systematic review of the recent literatureE Ernst
Complementary Medicine, Peninsula Medical School, University of Exeter, Devon, United Kingdom
Can J Cardiol 19:818-27. 2003..In conclusion, herbal medicinal products are regularly associated with serious cardiovascular adverse events but the size of this problem cannot be estimated at present. Vigilance and research seem to be the best way forward...
- Intra-herb pharmacokinetics interaction between quercetin and isorhamentinKe Lan
Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Acta Pharmacol Sin 29:1376-82. 2008..The intra-herb pharmacokinetics interactions between isorhamnetin and quercetin were investigated in the present study...
- Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 ratsSteven T S Lim
Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
Toxicol Sci 97:214-21. 2007....
- Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in ratsTung Hu Tsai
National Research Institute of Chinese Medicine, Taipei, Taiwan
Planta Med 71:640-5. 2005..This finding should be very important whenever herb-drug interactions would be possible for a herbal remedy...
- In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activityElisabetta Chieli
Dipartimento di Patologia Sperimentale, Universita degli Studi di Pisa, Via Roma 55, 56126 Pisa, Italy
Food Chem Toxicol 47:2703-10. 2009..Our results demonstrate, for the first time, that M. indica and polyphenols derived may affect the activity of the multidrug transporter P-gp ABCB1, suggesting the possibility of herb-drug interactions to be explored in depth...
- Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitroYue Huang
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612, USA
Curr Drug Saf 5:118-24. 2010....
- Complementary and alternative approaches to the treatment of persistent musculoskeletal painDebra K Weiner
Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 3313, USA
Clin J Pain 20:244-55. 2004..To review common complementary and alternative treatment modalities for the treatment of persistent musculoskeletal pain in older adults...
- Prescription pattern of traditional Chinese medicine for climacteric women in TaiwanY H Yang
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei
Climacteric 12:541-7. 2009..Traditional Chinese medicine (TCM) has become more popular as a therapy for symptom relief among menopause-aged women. The aim of this study was to analyze the utilization of TCM for climacteric women in Taiwan...
- Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in ratsChun Hua Xia
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
Planta Med 76:245-50. 2010..9 %, respectively. These in vivo and in vitro results demonstrated that SMI had the potential to inhibit the activities of hepatic CYP3A1/2 and CYP2C6, but might not significantly affect CYP1A2 and CYP2E1-mediated metabolism in rats...
- Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observationsFrancesca Borrelli
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
AAPS J 11:710-27. 2009..e., irinotecan, imatinib) drugs. Hyperforin, which is believed to contribute to the antidepressant action of St John's wort, is also strongly suspected to be responsible of most of the described interactions...
- St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literatureJ M Greeson
Center for Integrative Medicine, Thomas Jefferson University Hospital, Jefferson Medical College, Philadelphia, PA 19107 6799, USA
Psychopharmacology (Berl) 153:402-14. 2001..Given the current widespread use of this herbal remedy, it is important for medical professionals to understand the potential pharmacological pathways through which Hypericum may exert an antidepressant effect...
- 'They don't ask me so I don't tell them': patient-clinician communication about traditional, complementary, and alternative medicineBrian M Shelley
First Choice Community Healthcare, Albuquerque, New Mexico 87105, USA
Ann Fam Med 7:139-47. 2009..Such communication can be important in anticipating possible drug-herb interactions and in assuring agreement about therapeutic plans...
- Effect of Danggui and Honghua on Cytochrome P450 1A2, 2C11, 2E1 and 3A1 mRNA Expression in Liver of RatsYan Hong Li
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510406, China
Am J Chin Med 36:1071-81. 2008..Therefore, patients should be cautioned about the potential drug-herb interactions between Danggui or Honghua and prescription drugs that were metabolized by CYP1A2, 2E1 and 3A1 isoforms...
- The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression levelP M Mrozikiewicz
Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, University of Medical Sciences, Poznan, Poland
Phytomedicine 17:830-3. 2010..These findings suggest that Echinacea extract may influence the P450-mediated metabolism of different drugs and may initiate chemical carcinogenesis by activation of some compounds to their carcinogenic metabolites...
- South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides--a reviewE Joubert
Post Harvest and Wine Technology Division, ARC Infruitec Nietvoorbij, Private Bag X5026, Stellenbosch 7599, South Africa
J Ethnopharmacol 119:376-412. 2008....
- Physician knowledge of herbal toxicities and adverse herb-drug interactionsJeffrey R Suchard
Department of Emergency Medicine, University of California Irvine Medical Center, Orange, CA, USA
Eur J Emerg Med 11:193-7. 2004..To determine how knowledgeable physicians are regarding the toxic effects and drug interactions of herbal remedies...
- Dietary supplements for the prevention and treatment of coronary artery diseaseJeffrey Knox
Department of Medicine, University of Washington, Seattle, WA, USA
J Altern Complement Med 13:83-95. 2007..We set out to systematically review the dietary supplements available for the prevention and treatment of coronary artery disease...
- Herbal medicine use in parturientsDavid L Hepner
Department of Anaesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Anesth Analg 94:690-3; table of contents. 2002..6% of parturients) were the most likely to use herbal remedies (17.1% rate of use in this age group). Many parturients who took herbal remedies (46%) did so on the recommendation of their health care provider...
- Sho-saiko-to and Saiko-keisi-to, the traditional Chinese and Japanese herbal medicines, altered hepatic drug-metabolizing enzymes in mice and rats when administered orally for a long timeMitsuhiko Nose
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
J Pharm Pharmacol 55:1419-26. 2003..Sho-saiko-to and Saiko-keishi-to may potentially influence the drug-metabolizing enzymes in man, and would thus require much attention when used in the clinical situation...
- High use of complementary therapies in a New South Wales rural communityJ M Wilkinson
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia
Aust J Rural Health 9:166-71. 2001..Furthermore, these professionals should be alert to the potential for increased numbers of herb-drug interactions in rural communities...
- Use of traditional Chinese medicine in Singapore children: perceptions of parents and paediatriciansC H Loh
Medical School, Brookfield Health Sciences Complex, University College Cork, College Road, Cork, Ireland
Singapore Med J 50:1162-8. 2009..These are assessed in another arm of this study, with a set of predictive characteristics for their personal TCM use, their perceptions of herb/acupuncture safety, and their own referral to TCM eventually determined...
- Herbal medicine and cancer: an introductory overviewJonathan Treasure
Centre for Natural Healing, Ashland, OR 97520, USA
Semin Oncol Nurs 21:177-83. 2005....
- Crataegus orientalis associated multiorgan hypersensitivity reaction and acute renal failureMehmet Horoz
Department of Internal Medicine, Division of Nephrology, Mersin Universitiy, School of Medicine, Mersin, Turkey
Intern Med 47:2039-42. 2008..We report a case of multisystem hypersensitivity reaction and progressive acute renal failure associated with the consumption of Crataegus orientalis...
- Herbal remedies for menopausal symptoms: are we cautious enough?Ronit Haimov-Kochman
Division of Obstetrics and Gynaecology, Hadassah Hebrew University Hospital, Jerusalem, Israel
Eur J Contracept Reprod Health Care 13:133-7. 2008..To evaluate adverse effects of herbal remedies consumed by menopausal women for control of the climacteric syndrome...
- Emerging significance of P-glycoprotein in understanding drug disposition and drug interactions in psychopharmacologyStanley W Carson
Department of Pharmacy, Department of Psychiatry, CB 7360, Beard Hall, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
Psychopharmacol Bull 36:67-81. 2002..More research is needed in the field of psychopharmacology to classify central nervous system-active P-gp substrates and to characterize the utility of modulating P-gp activity at the blood-brain barrier...
- Modulation of Opioid Effects by Garlic SupplementsDanny Shen; Fiscal Year: 2007..The results will guide further studies on the liability of adverse herb-drug interactions with garlic in chemotherapy and palliative treatment of cancer. [unreadable] [unreadable]..
- American Society of Pharmacognosy 47th Annual Meeting: Natural Products on TargetJohn Cassady; Fiscal Year: 2007..abstract_text> ..
- Early Identification of Adverse Reactions to HerbsStephen Bent; Fiscal Year: 2007..Ultimately, this research strives to identify improved methods for the early detection of adverse events, providing patients with a safer environment to achieve the potential benefits of herbal products. ..
- Ginkgo Biloba Extract & The Insulin Resistance SyndromeGeorge Kudolo; Fiscal Year: 2004..The results of this study should also provide valuable information for designing new therapeutic strategies for the treatment of diseases in the insulin resistance syndrome. ..
- CAM Curriculum at the University of WashingtonRonald Schneeweiss; Fiscal Year: 2005..abstract_text> ..
- Herb-Drug Glucuronidation InteractionsReginald F Frye; Fiscal Year: 2011....
- Safety, Efficacy, and Mechanisms in American Ginseng in HIV-Related FatigueAdriana S A Andrade; Fiscal Year: 2012..This proposal will allow us to rigorously investigate a novel treatment for HIV- related fatigue and expand the current knowledge of herbal-ARV interactions. ..
- Computer-based Patient Provider Communication about CAM UseWILLIAM Z TAN; Fiscal Year: 2011....
- A Data-mining Approach to CAM Medication ReconciliationWILLIAM Z TAN; Fiscal Year: 2012....
- COMPOSITION, ACTIVITY AND DRUG INTERACTIONS OF ECHINACEACYNTHIA WENNER; Fiscal Year: 2004..By addressing these aims, Dr. Wenner will gain strong research skills in botanical medicine and the expertise necessary to significantly impact this field. ..
- Effects of Ginseng and Ginkgo on Drug Disposition in ManAryeh Hurwitz; Fiscal Year: 2003..Interactions of chronic ginseng and ginkgo with drug-metabolizing pathways and with cognitive function will thus be determined. ..
- AGING AND CYP-MEDIATED HERB-DRUG INTERACTIONSBill Gurley; Fiscal Year: 1999..John's wort modulate specific hepatic CYP activities (i.e. CYP1A2, CYP2D6, CYP2E1, and CYP3A4); and (2) whether aging potentiates the risk of CYP-mediated herb-drug interactions. ..
- Transcription Activation-Based Herb-Drug InteractionsJian Yang; Fiscal Year: 2009....
- Herb Drug InteractionsGary Henderson; Fiscal Year: 2004..abstract_text> ..
- Clinical Assessment of Herb-Drug InteractionsBill Gurley; Fiscal Year: 2005..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
- International Center of TCM for CancerLorenzo Cohen; Fiscal Year: 2004....
- Acupuncture treatment for post-thoracotomy pain syndromeBarrie Cassileth; Fiscal Year: 2007..The research has the potential of leading to a new treatment option to improve the quality of life of cancer patients and cancer survivors. [unreadable] [unreadable] [unreadable]..
- THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSISMERRILL E GERSHWIN; Fiscal Year: 2010..abstract_text> ..
- Antipsychotics and Mortality in Older PatientsHELEN KALES; Fiscal Year: 2009..The results of this study will be of immediate relevance to clinicians and policymakers. ..
- Biobehavioral Effects of Yoga During Cancer TreatmentLorenzo Cohen; Fiscal Year: 2007..abstract_text> ..
- Integrative Oncology Research Training Program at MSKCCBarrie Cassileth; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Racial Differences in Geriatric Antidepressant AdherenceHELEN KALES; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Organic Anion Transporters 2 & 3 in Renal & ToxicityDOUGLAS SWEET; Fiscal Year: 2008..abstract_text> ..
- Functional Impact of PENS for 65+ Chronic Low Back PainDebra Weiner; Fiscal Year: 2006....
- Screening Herbs for Drug InteractionsJOHN MARKOWITZ; Fiscal Year: 2002..Further, the proposed studies will complement existing and future NCCAM studies of agents such as St. John's wort and Gingko biloba. ..
- PRESURGICAL STRESS REDUCTION MENTAL HEALTH AND CANCERLorenzo Cohen; Fiscal Year: 2002..We hypothesize that pre-surgical stress management will reduce the negative impact of RP assessed by psychological, physiological, and quality of life measures. ..
- Acupuncture Treatment of Chronic Pain in Pancreatic CaBarrie Cassileth; Fiscal Year: 2002..Otherwise, an additional 19 patients will be accrued. A Phase III trial will be deemed warranted if there are 6 or more responses in total; this is consistent with a 30 percent response rate. ..
- Methodology of Phase I and II trials of anticancer CAMAndrew Vickers; Fiscal Year: 2004....
- Acupuncture for hot flashes in cancer pts: pilot for RCTBarrie Cassileth; Fiscal Year: 2004....
- Pharmacotherapy for Minor DepressionRobert Howland; Fiscal Year: 2004..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
- Society for Integrative OncologyBarrie Cassileth; Fiscal Year: 2004..This application requests support from NIH to cover costs that remain after anticipated organizational/donor support and registration fees are taken into account. ..
- Massage for Treatment of Pain Advanced CancerBarrie Cassileth; Fiscal Year: 2002..trial could be completed in less than two years, and if the 95 percent confidence interval for the difference between group means includes at least a 20 percent lower mean post-treatment pain score on massage than sham treatment ..
- Osteopuncture for OA-Associated Knee Pain & DisabilityDebra Weiner; Fiscal Year: 2005..In addition, mechanisms of action will be explored, and the impact of osteopuncture on health care costs determined. ..
- Biobehavioral Effects of Emotional Expression in CancerLorenzo Cohen; Fiscal Year: 2006..The effects of the intervention should be evident throughout recovery and across indices of quality of life, mental health, subjective symptoms of stress, and immune function. ..
- Effects of Hypericum Perforatum on Oral ContraceptivesPatricia Murphy; Fiscal Year: 2002..A concurrent aim is the development and refinement of a methodology for evaluating the risk of ovulation and unintended pregnancy from use of other herbs or medications during oral contraceptive use. ..
- COMPUTER AIDED STRESS REDUCTION, MENTAL HEALTH & CANCERLorenzo Cohen; Fiscal Year: 2002....
- St. John's Wort Effects on LevonorgestrelPatricia Murphy; Fiscal Year: 2006..The study protocol will be refined for use in future studies of levonorgestrel and other emergency contraceptive regimens. ..
- Ginkgo biloba for ECT-induced Memory DeficitsJOHN MARKOWITZ; Fiscal Year: 2003..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
- Scientific Advances in CAM by Allied Health and NursingRiva Touger Decker; Fiscal Year: 2003..Intended outcomes of the annual conferences include electronically published proceedings, new and collaborative research and CAM research agendas and priorities for allied health and nursing that can be shared with the key associations. ..
- P-Glycoprotein and Disposition of PsychostimulantsJOHN MARKOWITZ; Fiscal Year: 2005....
- BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMAMERRILL GERSHWIN; Fiscal Year: 2004..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..