Genomes and Genes
Summary: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
Publications284 found, 100 shown here
- A mammalian microRNA expression atlas based on small RNA library sequencingPablo Landgraf
Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Box 186, The Rockefeller University, New York, NY 10021, USA
Cell 129:1401-14. 2007..We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses...
- Sequencing and de novo analysis of a coral larval transcriptome using 454 GSFlxEli Meyer
University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
BMC Genomics 10:219. 2009..We have applied these methods to sequence the transcriptome of planulae larvae from the coral Acropora millepora...
- High-throughput gene and SNP discovery in Eucalyptus grandis, an uncharacterized genomeEvandro Novaes
School of Forest Resources and Conservation, University of Florida, PO Box 110410, Gainesville, USA
BMC Genomics 9:312. 2008..However, it is questionable how effective the sequencing of large numbers of short reads for species with essentially no prior gene sequence information will support contig assemblies and sequence annotation...
- Comprehensive comparative analysis of strand-specific RNA sequencing methodsJoshua Z Levin
Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA
Nat Methods 7:709-15. 2010..Our analysis provides a comprehensive benchmark, and our computational pipeline is applicable for assessment of future protocols in other organisms...
- Comprehensive transposon mutant library of Pseudomonas aeruginosaMichael A Jacobs
Department of Medicine, University of Washington Genome Center, Box 352145, Seattle, WA 98195 2145, USA
Proc Natl Acad Sci U S A 100:14339-44. 2003..The transposons used to generate the mutant collection have added features that should facilitate downstream studies of gene expression, protein localization, epistasis, and chromosome engineering...
- Transcriptome analysis of the brown planthopper Nilaparvata lugensJian Xue
Key Laboratory of Molecular Biology of Crop Pathogens and Insects of Ministry of Agriculture, Institute of Insect Science, Zhejiang University, Hangzhou, China
PLoS ONE 5:e14233. 2010..Genomic information for BPH is currently unavailable, and, therefore, transcriptome and expression profiling data for this species are needed as an important resource to better understand the biological mechanisms of BPH...
- Identification of grapevine microRNAs and their targets using high-throughput sequencing and degradome analysisVitantonio Pantaleo
Istituto di Virologia Vegetale, Consiglio Nazionale delle Ricerche, Torino, Italy
Plant J 62:960-76. 2010..Finally, 112 target mRNAs of known and 44 target mRNAs of new grapevine-specific miRNAs were identified by genomic-scale high-throughput sequencing of miRNA cleaved mRNAs...
- Identification of miRNAs and their target genes in developing soybean seeds by deep sequencingQing Xin Song
State Key Laboratory of Plant Genomics, Genome Biology Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, PR China
BMC Plant Biol 11:5. 2011....
- Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomesIwanka Kozarewa
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Nat Methods 6:291-5. 2009..We illustrate this by generating and analyzing DNA sequences from extremely (G+C)-poor (Plasmodium falciparum), (G+C)-neutral (Escherichia coli) and (G+C)-rich (Bordetella pertussis) genomes...
- An extensive class of small RNAs in Caenorhabditis elegansR C Lee
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Science 294:862-4. 2001..elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse...
- Simple cDNA normalization using kamchatka crab duplex-specific nucleasePavel A Zhulidov
Shemiakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho Maklaya 16 10, 117871 Moscow, Russia
Nucleic Acids Res 32:e37. 2004..We also employed DSN normalization to normalize cDNA from nervous tissues of the marine mollusc Aplysia californica (a popular model organism in neuroscience) to illustrate further the efficiency of the normalization technique...
- Transcriptome-wide identification of microRNA targets in riceYong Fang Li
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
Plant J 62:742-59. 2010..A closer inspection of these fragments revealed a unique pattern distinct from siRNA-producing loci. This attribute can serve as one of the ancillary criteria for separating miRNAs from siRNAs in plants...
- Global identification of microRNA-target RNA pairs by parallel analysis of RNA endsMarcelo A German
Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711, USA
Nat Biotechnol 26:941-6. 2008..This versatile approach will affect the study of other aspects of RNA processing beyond miRNA-target RNA pairs...
- Targeted capture and massively parallel sequencing of 12 human exomesSarah B Ng
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Nature 461:272-6. 2009..This strategy may be extendable to diseases with more complex genetics through larger sample sizes and appropriate weighting of non-synonymous variants by predicted functional impact...
- Reverse transcriptase template switching: a SMART approach for full-length cDNA library constructionY Y Zhu
CLONTECH Laboratories, Palo Alto, CA, USA
Biotechniques 30:892-7. 2001..cDNA libraries generated using this method will be useful for accelerating the collection of mRNA 5' end sequence information, which is currently very limited in GenBank...
- Identification of Birds through DNA BarcodesPaul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario, Canada
PLoS Biol 2:e312. 2004..The growing evidence for the effectiveness of DNA barcodes as a basis for species identification supports an international exercise that has recently begun to assemble a comprehensive library of COI sequences linked to named specimens...
- A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thalianaRamya Rajagopalan
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genes Dev 20:3407-25. 2006....
- High-throughput sequencing of Medicago truncatula short RNAs identifies eight new miRNA familiesGyorgy Szittya
School of Biological Sciences, University of East Anglia, Norwich, UK
BMC Genomics 9:593. 2008..High-throughput sequencing technology is capable to identify novel short RNAs in plant species. We used Solexa sequencing to find new microRNAs in one of the model legume species, barrel medic (Medicago truncatula)...
- Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm developmentGuru Jagadeeswaran
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
BMC Genomics 11:52. 2010..Deep sequencing of small RNAs isolated from different stages of silkworm is a powerful tool not only for measuring the changes in miRNA profile but also for discovering novel miRNAs...
- Stem cell transcriptome profiling via massive-scale mRNA sequencingNicole Cloonan
Expression Genomics Laboratory, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, Queensland, 4072, Australia
Nat Methods 5:613-9. 2008....
- Transcriptome characterization and high throughput SSRs and SNPs discovery in Cucurbita pepo (Cucurbitaceae)José Blanca
Institute for the Conservation and Breeding of Agricultural Biodiversity, Universidad Politécnica de Valencia COMAV UPV, Camino de Vera s n, 46022 Valencia, Spain
BMC Genomics 12:104. 2011..However, these tools are still lacking in the Cucurbita genus, thus limiting gene discovery and the process of breeding...
- A physical map of the 1-gigabase bread wheat chromosome 3BEtienne Paux
Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
Science 322:101-4. 2008..This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach...
- Whole exome capture in solution with 3 Gbp of dataMatthew N Bainbridge
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Genome Biol 11:R62. 2010....
- Identification of microRNAs and other small regulatory RNAs using cDNA library sequencingMarkus Hafner
Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10065, USA
Methods 44:3-12. 2008..This protocol includes the use of new deep sequencing methods (454/Roche and Solexa) to facilitate the characterization of diverse sequence pools of small RNAs...
- Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)Roy R Chaudhuri
Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
BMC Genomics 10:291. 2009..An important starting point for the development of new antimicrobial drugs is the identification of "essential" genes that are important for bacterial survival and growth...
- Introducing DOTUR, a computer program for defining operational taxonomic units and estimating species richnessPatrick D Schloss
Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Dr, Madison, WI 53706, USA
Appl Environ Microbiol 71:1501-6. 2005..We anticipate that an equivalent extent of sampling for soil would require sampling more than 10,000 sequences, almost 100 times the size of typical sequence collections obtained from soil...
- Novel and nodulation-regulated microRNAs in soybean rootsSenthil Subramanian
Donald Danforth Plant Science Center, 975 N Warson Road, St Louis, MO 63132, USA
BMC Genomics 9:160. 2008..g. soybean) and rhizobia bacteria (e.g. Bradyrhizobium japonicum) results in root nodules where the majority of biological nitrogen fixation occurs. We sought to identify microRNAs (miRNAs) regulated during soybean-B. japonicum symbiosis...
- Metagenomics: genomic analysis of microbial communitiesChristian S Riesenfeld
Department of Plant Pathology, University of Wisconsin Madison, Wisconsin 53706, USA
Annu Rev Genet 38:525-52. 2004..This review describes progress toward understanding the biology of uncultured Bacteria, Archaea, and viruses through metagenomic analyses...
- Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit developmentFiammetta Alagna
CNR Institute of Plant Genetics, Via Madonna Alta 130, 06128 Perugia, Italy
BMC Genomics 10:399. 2009..454 pyrosequencing was used to enrich the very few sequence data currently available for the Olea europaea species and to identify genes involved in expression of fruit quality traits...
- New screening software shows that most recent large 16S rRNA gene clone libraries contain chimerasKevin E Ashelford
Cardiff School of Biosciences, Cardiff University, Main Building, Park Place, P O Box 915, Cardiff CF10 3TL, United Kingdom
Appl Environ Microbiol 72:5734-41. 2006..Mallard is freely available from our website at http://www.cardiff.ac.uk/biosi/research/biosoft/...
- MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA librariesMerav Bar
Divisions of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Stem Cells 26:2496-505. 2008..Disclosure of potential conflicts of interest is found at the end of this article...
- Transcriptome profiling of early developing cotton fiber by deep-sequencing reveals significantly differential expression of genes in a fuzzless/lintless mutantQin Qin Wang
Department of Biochemistry and Molecular Biology, College of Life Science, Nanjing Agricultural University, Nanjing, China
Genomics 96:369-76. 2010..Overall, the deep-sequencing analyses demonstrate the high degree of transcriptional complexity in early developing fibers and represent a major improvement over the microarrays for analyzing transcriptional changes on a large scale...
- Comparison of next generation sequencing technologies for transcriptome characterizationP Kerr Wall
Department of Biology, Institute of Molecular Evolutionary Genetics, and The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
BMC Genomics 10:347. 2009..19). We also generated 454-GS20 sequences and de novo assemblies for the basal eudicot California poppy (Eschscholzia californica) and the magnoliid avocado (Persea americana) using a variety of methods for cDNA synthesis...
- Tuning genetic control through promoter engineeringHal Alper
Department of Chemical Engineering, Massachusetts Institute of Technology, Room 56 469, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 102:12678-83. 2005....
- BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammalsIna Poser
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Nat Methods 5:409-15. 2008..The same high-throughput approach will be generally applicable to other model systems...
- A scalable, fully automated process for construction of sequence-ready human exome targeted capture librariesSheila Fisher
Genome Sequencing Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA
Genome Biol 12:R1. 2011..Significant process improvements and a series of in-process quality control checkpoints are also added. These process improvements can also be used in a manual version of the protocol...
- Comparison of the transcriptomes of American chestnut (Castanea dentata) and Chinese chestnut (Castanea mollissima) in response to the chestnut blight infectionAbdelali Barakat
The School of Forest Resources, Department of Horticulture, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
BMC Plant Biol 9:51. 2009....
- Identification and characterization of novel amphioxus microRNAs by Solexa sequencingXi Chen
Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Hankou Road, Nanjing, Jiangsu 210093, PR China
Genome Biol 10:R78. 2009..While the number of known human and murine miRNAs is continuously increasing, information regarding miRNAs from other species such as amphioxus remains limited...
- Hidden layers of human small RNAsHideya Kawaji
Genome Science Laboratory, Discovery and Research Institute, RIKEN Wako Main Campus, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
BMC Genomics 9:157. 2008....
- Transposase mediated construction of RNA-seq librariesJason Gertz
HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
Genome Res 22:134-41. 2012..Our results show that high-quality RNA-seq libraries can be constructed efficiently and in an automatable fashion using transposition technology...
- Whole genome wide expression profiles of Vitis amurensis grape responding to downy mildew by using Solexa sequencing technologyJiao Wu
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China
BMC Plant Biol 10:234. 2010..cv. Zuoshan-1. Our goal is to identify genes that are involved in resistance to grape DM disease...
- Mechanism of chimera formation during the Multiple Displacement Amplification reactionRoger S Lasken
J Craig Venter Institute, Rockville, MD 20850, USA
BMC Biotechnol 7:19. 2007..Determining the source of the DNA rearrangements would be an important step towards reducing or eliminating them...
- Rapid evolution and selection inferred from the transcriptomes of sympatric crater lake cichlid fishesK R Elmer
Department of Biology, University of Konstanz, Germany
Mol Ecol 19:197-211. 2010..We conclude that next-generation sequencing technologies allow us to infer natural selection acting to diversify the genomes of young species, such as crater lake cichlids, with much greater scope than previously possible...
- High-throughput SuperSAGE for digital gene expression analysis of multiple samples using next generation sequencingHideo Matsumura
Iwate Biotechnology Research Center, Kitakami, Japan
PLoS ONE 5:e12010. 2010....
- An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysisQi Tang
Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
BMC Genomics 12:343. 2011..Among them, mogroside V is nearly 300 times sweeter than sucrose. However, little is known about mogrosides biosynthesis in S. grosvenorii, especially the late steps of the pathway...
- Transcriptome sequencing and annotation of the microalgae Dunaliella tertiolecta: pathway description and gene discovery for production of next-generation biofuelsHamid Rismani-Yazdi
Department of Chemical and Environmental Engineering, Yale University, New Haven, CT 06511, USA
BMC Genomics 12:148. 2011..Here we describe the sequencing and de novo transcriptome assembly for the non-model microalgae species, Dunaliella tertiolecta, and identify pathways and genes of importance related to biofuel production...
- Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidusThean Hock Tang
Institute of Experimental Pathology, Von Esmarch Strasse 56, 48149 Munster, Germany
Proc Natl Acad Sci U S A 99:7536-41. 2002..Our study further supports the importance of snmRNAs in all three domains of life...
- A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screenJason Moffat
Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA
Cell 124:1283-98. 2006..This work provides a widely applicable resource for loss-of-function screens, as well as a roadmap for its application to biological discovery...
- An oligo-based microarray offers novel transcriptomic approaches for the analysis of pathogen resistance and fruit quality traits in melon (Cucumis melo L.)Albert Mascarell-Creus
Molecular Genetics Department, Centre for Research in Agricultural Genomics CRAG CSIC IRTA UAB, Barcelona 08034, Spain
BMC Genomics 10:467. 2009..However, the unprecedented existence of a transcriptomic approaches in melon, highlight the importance of designing new tools for high-throughput analysis of gene expression...
- Functional metagenomics for enzyme discovery: challenges to efficient screeningTaku Uchiyama
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
Curr Opin Biotechnol 20:616-22. 2009..This review highlights recent studies on the screening of metagenomic libraries and discusses some possible solutions for overcoming the expression problem in function-based screening...
- Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytesToshiaki Watanabe
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
Nature 453:539-43. 2008..Our results reveal a role for endogenous siRNAs in mammalian oocytes and show that organisms lacking RdRP activity can produce functional endogenous siRNAs from naturally occurring dsRNAs...
- Community genomics among stratified microbial assemblages in the ocean's interiorEdward F DeLong
Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 311:496-503. 2006..Comparative genomic analyses of stratified microbial communities have the potential to provide significant insight into higher-order community organization and dynamics...
- A combined approach of high-throughput sequencing and degradome analysis reveals tissue specific expression of microRNAs and their targets in cucumberWeihua Mao
Department of Horticulture, Zhejiang University, Hangzhou, China
PLoS ONE 7:e33040. 2012..Our study provides an overview of miRNA expression profile and interaction between miRNA and target, which will help further understanding of the important roles of miRNAs in cucumber plants...
- Cost-effective, high-throughput DNA sequencing libraries for multiplexed target captureNadin Rohland
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Genome Res 22:939-46. 2012..We illustrate the power and effectiveness of this approach on about 2000 samples from a prostate cancer study...
- Critical assessment of assembly strategies for non-model species mRNA-Seq data and application of next-generation sequencing to the comparison of C(3) and C(4) speciesAndrea Bräutigam
Plant Biochemistry, Universitatsstrasse 1, Heinrich Heine University, D 40225 Dusseldorf, Germany
J Exp Bot 62:3093-102. 2011..The pathways and cellular processes tagged in the transcriptome assemblies reflect processes of a mature leaf. The databases are useful for extracting transcripts related to C(4) processes as full-length or nearly full-length sequences...
- Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi libraryJean François Rual
Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genome Res 14:2162-8. 2004..The versatility inherent to the Gateway system suggests that additional HT-RNAi libraries can now be readily generated to perform gene knockdowns under various conditions, increasing the possibilities for phenome mapping in C. elegans...
- A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogateLarry A Gallagher
Department of Genome Sciences, University of Washington, Campus Box 355065, 1705 NE Pacific Street, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 104:1009-14. 2007..The library provides a resource for virtually complete identification of genes involved in virulence and other nonessential processes...
- Linear amplification for deep sequencingWieteke A M Hoeijmakers
Department of Molecular Biology, Faculty of Science, Nijmegen Center for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
Nat Protoc 6:1026-36. 2011..Moreover, in contrast to amplification-free methods, LADS can generate sequencing libraries from a few nanograms of DNA, which is essential for all applications in which the starting material is limited...
- Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricusThean Hock Tang
Institute for Research in Molecular Medicine, University Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelatan, Malaysia
Mol Microbiol 55:469-81. 2005..In conclusion, this is the first report of stably expressed antisense RNAs in an archaeal species and it raises the prospect that antisense-based mechanisms are also used widely in Archaea to regulate gene expression...
- Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA librariesStacia K Wyman
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 4:e5311. 2009..A critical step toward these goals is to establish a comprehensive view of miRNAs expressed in epithelial ovarian cancer tissues as well as in normal ovarian surface epithelial cells...
- MicroRNAs of Bombyx mori identified by Solexa sequencingShiping Liu
The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Tiansheng Road, Beibei, Chongqing 400715, PR China
BMC Genomics 11:148. 2010....
- PILER: identification and classification of genomic repeatsRobert C Edgar
Bioinformatics 21:i152-8. 2005..We describe PILER, a package of efficient search algorithms for identifying such patterns. Novel repeats found using PILER are reported for Homo sapiens, Arabidopsis thalania and Drosophila melanogaster...
- FACS-optimized mutants of the green fluorescent protein (GFP)B P Cormack
Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305 5402, USA
Gene 173:33-8. 1996..coli, the folding of the mutant proteins is more efficient than folding of wt GFP. These two properties contribute to a greatly increased (100-fold) fluorescence intensity, making the mutants useful for a number of applications...
- Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequencesPablo F Cavagnaro
Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
Mol Genet Genomics 281:273-88. 2009..Moreover, among eight dicot species used for comparison purposes, carrot BES had highest homology to protein-coding sequences from tomato. This deep-coverage library will aid carrot breeding and genetics...
- Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencingMinseon Cho
Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 107:15373-8. 2010..Given that many biocombinatorial libraries are encoded with nucleic acids, we extrapolate that our method may be extended to other types of libraries for a range of molecular functions...
- Large-scale analysis of full-length cDNAs from the tomato (Solanum lycopersicum) cultivar Micro-Tom, a reference system for the Solanaceae genomicsKoh Aoki
Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Japan
BMC Genomics 11:210. 2010....
- A defined transposon mutant library and its use in identifying motility genes in Vibrio choleraeD Ewen Cameron
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:8736-41. 2008..cholerae flagellum appears to be derived from the cell's outer membrane, FlgT may play a direct role in flagellar sheath formation...
- A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454Niall J Lennon
Genome Sequencing Platform, Broad Institute of MIT and Harvard, 320 Charles St, Cambridge, MA 02141, USA
Genome Biol 11:R15. 2010..Using this methodology, one technician can create 96 sequence-ready 454 libraries in 2 days, a dramatic improvement over the standard method...
- Uncultured soil bacteria are a reservoir of new antibiotic resistance genesChristian S Riesenfeld
Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
Environ Microbiol 6:981-9. 2004..The results indicate that soil bacteria are a reservoir of antibiotic resistance genes with greater genetic diversity than previously accounted for, and that the diversity can be surveyed by a culture-independent method...
- Construction of small RNA cDNA libraries for deep sequencingCheng Lu
Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
Methods 43:110-7. 2007..Here, we describe the methods used in our laboratory to construct small RNA cDNA libraries for high-throughput sequencing using technologies such as MPSS, 454 or SBS...
- Genome-wide identification of Medicago truncatula microRNAs and their targets reveals their differential regulation by heavy metalZhao Sheng Zhou
Department of Biochemistry and Molecular Biology, College of Life Science, Nanjing Agricultural University, Nanjing, China
Plant Cell Environ 35:86-99. 2012..Finally, 130 targets for 58 known (37 conserved and 21 non-conserved) miRNA families and 37 targets for 18 new M. truncatula-specific candidate miRNA families were identified by high-throughput degradome sequencing approach...
- A simple method for directional transcriptome sequencing using Illumina technologyNicholas J Croucher
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Cambridgeshire CB10 1SA, UK
Nucleic Acids Res 37:e148. 2009..Hence, this simple method should prove a useful tool in aiding genome annotation and gene expression studies in both prokaryotes and eukaryotes...
- Conserved and novel miRNAs in the legume Phaseolus vulgaris in response to stressCatalina Arenas-Huertero
Departamento de Biologia Molecular de Plantas, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Av Universidad 2001, Cuernavaca, Morelos, Mexico
Plant Mol Biol 70:385-401. 2009..vulgaris. We propose that the novel miRNAs present in common bean and other legumes, are involved in regulation of legume-specific processes including adaptation to diverse external cues...
- Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoireJacob Glanville
Research Informatics, Rinat Pfizer Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 106:20216-21. 2009..5 x 10(10). The results provide insights into the role of IgM diversification, display library construction, and productive germline usages in antibody libraries and the humoral repertoire...
- Enrichment of sequencing targets from the human genome by solution hybridizationRyan Tewhey
Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, 3344 N Torrey Pines Court, La Jolla, CA 92037, USA
Genome Biol 10:R116. 2009..9 Mb of sequence target. We demonstrate that the tiling probe frequency is important for generating sequence data with high uniform coverage of targets. We obtained 93% sensitivity to detect SNPs, with a calling accuracy greater than 99%...
- Enrichment of a set of microRNAs during the cotton fiber developmentPieter Bas Kwak
Department of Biochemistry and Molecular Biology, College of Life Science, Nanjing Agricultural University, Nanjing, PR China
BMC Genomics 10:457. 2009..Small RNAs regulate many aspects of plant growth and development. However, whether small RNAs are involved in regulation of fiber cell development is unknown...
- Strategies for microsatellite isolation: a reviewL Zane
Dipartimento di Biologia, Università di Padova Via Ugo Bassi 58 B, 35121, Padova, Italy
Mol Ecol 11:1-16. 2002..In addition, we propose a fast and easy protocol which is a combination of different published methods...
- MicroRNA transcriptome profiles during swine skeletal muscle developmentTara G McDaneld
USDA ARS Meat Animal Research Center, Clay Center, NE, USA
BMC Genomics 10:77. 2009..To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating satellite cells, three stages of fetal growth, day-old neonate, and the adult...
- Deep sampling of the Palomero maize transcriptome by a high throughput strategy of pyrosequencingJulio C Vega-Arreguín
Laboratorio Nacional de Genómica para la Biodiversidad, Cinvestav Campus Guanajuato, Carretera Irapuato León, Irapuato, Gto, Mexico
BMC Genomics 10:299. 2009..In addition, little emphasis has been given to efforts aiming at an estimation of the overall transcriptional universe found in a multicellular organism at a specific developmental stage...
- Metagenomic analyses: past and future trendsCarola Simon
Abteilung Genomische und Angewandte Mikrobiologie, Institut fur Mikrobiologie und Genetik, Georg August Universitat, Grisebachstr 8, 37077 Gottingen, Germany
Appl Environ Microbiol 77:1153-61. 2011....
- HIV-1 proviral DNA excision using an evolved recombinaseIndrani Sarkar
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Science 316:1912-5. 2007..Although a long way from use in the clinic, we speculate that this type of technology might be adapted in future antiretroviral therapies, among other possible uses...
- Development of 5006 full-length CDNAs in barley: a tool for accessing cereal genomics resourcesKazuhiro Sato
Research Institute for Bioresources, Okayama University, Kurashiki, Japan
DNA Res 16:81-9. 2009..Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under accession nos AK248134-AK253139. The online database with annotation is available at http://www.shigen.nig.ac.jp/barley/...
- Digital gene expression signatures for maize developmentAndrea L Eveland
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Plant Physiol 154:1024-39. 2010..Results from this study provide a basis for the analysis of short-read expression data in maize and resolved specific expression signatures that will help define mechanisms of action for the RA3 gene...
- Reverse methanogenesis: testing the hypothesis with environmental genomicsSteven J Hallam
Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA
Science 305:1457-62. 2004..These genome-based observations support previous hypotheses and provide an informed foundation for metabolic modeling of anaerobic methane oxidation...
- Identification and characterization of microRNAs and endogenous siRNAs in Schistosoma japonicumLili Hao
Laboratory of Parasitology, Institute of Pathogen Biology Institute of Basic Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China
BMC Genomics 11:55. 2010..The objective of this study is to investigate the transcriptional profile and potential function of the small non-coding RNAs in the development of S. japanicum...
- Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescenceKim B Jensen
Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Proc Natl Acad Sci U S A 103:11958-63. 2006..Lrig1 acted in part by negatively regulating the Myc promoter. We propose that Lrig1 maintains epidermal stem cells in a quiescent nondividing state, and that Lrig1 down-regulation triggers proliferation...
- Computational annotation of genes differentially expressed along olive fruit developmentGiulio Galla
Scuola Superiore Sant Anna Pisa, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
BMC Plant Biol 9:128. 2009..This study deals with the identification of large sets of differentially expressed genes in developing olive fruits and the subsequent computational annotation by means of different software...
- Genome-scale transcriptome analysis of the desert poplar, Populus euphraticaQiang Qiu
Molecular Ecology Group, Key Laboratory of Arid and Grassland Ecology, Lanzhou University, Lanzhou 730000, China
Tree Physiol 31:452-61. 2011..euphratica to date. The genetic knowledge acquired should be very useful for future studies of the molecular adaptation of this tree species to abiotic stress and facilitate genetic manipulation of other poplar species...
- Bioinformatic analysis of ESTs collected by Sanger and pyrosequencing methods for a keystone forest tree species: oakSaneyoshi Ueno
INRA, UMR 1202 BIOGECO, 69 route d Arcachon, F 33612 Cestas, France
BMC Genomics 11:650. 2010....
- Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approachC Manichanh
Unité d Ecologie et de Physiologie du Système Digestif, INRA UEPSD, 78350 Jouy en Josas, France
Gut 55:205-11. 2006..However, investigation of such a complex ecosystem is difficult, even with culture independent molecular approaches...
- A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replicationMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 284:19463-73. 2009..We discuss the similarities and differences between our shRNA findings for HIV-1 using a spreading infection assay in human Jurkat T-cells and results from other investigators who used siRNA-based screenings in HeLa or 293T cells...
- Development of genomic resources for Citrus clementina: characterization of three deep-coverage BAC libraries and analysis of 46,000 BAC end sequencesJavier Terol
Centro de Genomica, Instituto Valenciano de Investigaciones Agrarias, Carretera Moncada, Náquera, Km 4, 5 Moncada, Valencia, E46113, Spain
BMC Genomics 9:423. 2008..000 BAC end sequences. Clementine is a diploid plant with an estimated haploid genome size of 367 Mb and 2n = 18 chromosomes, which makes feasible the use of genomics tools to boost genetic improvement...
- RNPomics: defining the ncRNA transcriptome by cDNA library generation from ribonucleo-protein particlesMathieu Rederstorff
Division of Genomics and RNomics, Innsbruck Biocentre, Innsbruck Medical University, Innsbruck and Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria
Nucleic Acids Res 38:e113. 2010..Additionally, a number of ncRNAs mapped to repetitive sequences. Thus, our RNP approach provides an efficient way to identify new functional small ncRNA candidates, involved in RNP formation...
- The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformansBrendan J Loftus
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 307:1321-4. 2005..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
- Functional conservation of an insect odorant receptor gene across 250 million years of evolutionWalton D Jones
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Curr Biol 15:R119-21. 2005..The medical and economic impact of these animals can be ascribed in part to the sensitivity and selectivity of their olfactory systems, essential for location of their preferred plant and animal hosts...
- Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytesOliver H Tam
Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nature 453:534-8. 2008..Our findings indicate a function for pseudogenes in regulating gene expression by means of the RNA interference pathway and may, in part, explain the evolutionary pressure to conserve argonaute-mediated catalysis in mammals...
- Comparative metagenomics of microbial communitiesSusannah Green Tringe
Department of Energy DOE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
Science 308:554-7. 2005..The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments...
- Global patterns of diversity and community structure in marine bacterioplanktonT Pommier
Department of Natural Science, Kalmar University, SE 39182, Kalmar, Sweden
Mol Ecol 16:867-80. 2007..The general processes behind those patterns are likely to be comparable across taxa and major global biomes...
- Circular polymerase extension cloning for high-throughput cloning of complex and combinatorial DNA librariesJiayuan Quan
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
Nat Protoc 6:242-51. 2011..CPEC is highly efficient, accurate and user friendly. Once the inserts and the linear vector have been prepared, the CPEC reaction can be completed in 10 min to 3 h, depending on the complexity of the gene libraries...
- Generation and analysis of transcriptomic resources for a model system on the rise: the sea anemone Aiptasia pallida and its dinoflagellate endosymbiontShinichi Sunagawa
School of Natural Sciences, University of California, Merced, CA 95344, USA
BMC Genomics 10:258. 2009..a system that is gaining popularity as a model to study cellular, molecular, and genomic questions related to cnidarian-dinoflagellate symbioses...
- Identification of small non-coding RNAs from mitochondria and chloroplastsBirgit Lung
Innsbruck Biocenter, Division of Genomics and RNomics, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
Nucleic Acids Res 34:3842-52. 2006..The absence from our libraries of abundant small RNA species that are not encoded by the organellar genomes suggests that the import of RNAs into cell organelles is of very limited significance or does not occur at all...
- OCULAR SURFACE STEM CELL GENESJOSE WOLOSIN; Fiscal Year: 2006..Given our current very limited understanding of stem cells, acquisition of a gene library is an essential, high impact step in the long path to unravel the process underlying the functionality of these ..
- Expanding the Scope of Protein EvolutionDavid R Liu; Fiscal Year: 2010..including those described above) have adopted a format in which a discrete mutagenesis step generates a gene library, a discrete screen or selection step enriches the library for desired members, a discrete DMA or RNA isolation ..
- Human Proteome Arrays for Auto-Antibody Identification in Clinical Cancer StudiesJohn H Kenten; Fiscal Year: 2011..We will test normal and cancer patient sera against protein arrays generated using a gene library expressing human full-length proteins...
- SEEKING THE YEAST SPARKING STEROLMartin Bard; Fiscal Year: 1991..A Candida gene library will be used to complement existing Saccharomyces erg mutations or the cloned Saccharomyces ERG genes will be ..
- GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUSEric H Davidson; Fiscal Year: 2013DESCRIPTION (provided by applicant): This revised proposal seeks support for the Gene Library Resource for the purple sea urchin, Strongylocentrotus purpuratus...
- GENETICS OF H. AEGYPTIUS BRAZILIAN PURPURIC FEVER CLONELuis Actis; Fiscal Year: 2000..This will be achieved by constructing a gene library using the innovative subtraction genomic hybridization technique...
- THE STRUCTURAL BASIS OF RELAXIN ACTIONChristian Schwabe; Fiscal Year: 1990..to obtain partial sequence information concerning the relaxin receptor that would eventually aid in the construction of a nucleotide probe with which a relaxin receptor-coding sequence may be isolated from the appropriate gene library.
- Plague vaccine candidates by a functional genomic screenKathryn Sykes; Fiscal Year: 2002..pestis genome for protective antigens, ii) identify protocols for producing a complete Y. pestis gene library iii) define the optimal gene dose and design for this genome screen by testing Y...
- Single Cell Screen for Enzyme Expression and ActivityJustin Stege; Fiscal Year: 2001Diversa leverages its proprietary technology in gene library generation and gene evolution to provide robust bio-catalytic solutions across a broad spectrum of chemical industries...
- Chemokine Receptor Chimeras by Synthetic Gene LibraryMichael Dustin; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Target Validation using Gene Knockouts in Somatic CellsRobert Finney; Fiscal Year: 2002..Specific aims proposed are 1) generation of a 2,000 gene library for gene knockouts, 2) creation of 10 gene knockout vectors, 3) inactivation of 10 genes in 2 human pancreatic ..
- PROFILING AUTOANTIGENS IN UVEITISWei Li; Fiscal Year: 2010..These efforts will advance our understanding of the disease etiology and prognosis, and improve the diagnosis and therapy. ..
- Modulation of CD4+ T cells in autoimmune uveitisWei Li; Fiscal Year: 2003..These studies will not only yield new insights for the underlying causes and pathogenesis of autoimmune uveitis, but may also lead to a more selective immunotherapy for the disease. ..
- Investigating the nature of prestin-associated proteinsJing Zheng; Fiscal Year: 2007..This knowledge may make it possible to manipulate OHC function for therapeutic purposes. ..
- Metabolism of Carcinogens and Drugs by Human P450sF Guengerich; Fiscal Year: 2005..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
- Microevolution of conserved developmental genesPAUL HOHENLOHE; Fiscal Year: 2007..Conversely, lack of variation and a negative selection result would suggest that other loci or regulatory pathways are involved in vertebral development. [unreadable] [unreadable] [unreadable]..
- Intrnational Clubfoot SymposiumJose Morcuende; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- 400 MHz NMR Spectrometer for CSU Chemistry FacilityRobert Williams; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Synthesis and Mechanism of DNA Cross-linking of FR900482Robert Williams; Fiscal Year: 2008..unreadable] [unreadable]..
- Genetic Mapping of Familial Idiopathic ScoliosisJose Morcuende; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- In vivo regulation of M. tuberculosis cell wall lipidsLee W Riley; Fiscal Year: 2010..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
- MULTIVALENT VACCINE FOR LYMPHATIC FILARIASISRamaswamy Kalyanasundaram; Fiscal Year: 2010..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
- MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHYCLAUDIA T KAPPEN; Fiscal Year: 2010..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
- MENTORED QUANTITATIVE RESEARCH CAREER DEVELOPMENT AWARDGregory Grant; Fiscal Year: 2005..4) To complete a six-month lab rotation, the exact details of which are still to be worked out. This has been informally arranged with Dr. Vivian Cheung (Children's Hospital of Philadelphia). ..
- Genome-wide discovery of beta cell gene control elementsClaudia Kappen; Fiscal Year: 2004..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
- ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSISLee Riley; Fiscal Year: 2001....
- MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSISLee Riley; Fiscal Year: 2002..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
- NEGATIVE REGULATION OF GENE EXPRESSION BY VITAMIN DNICHOLAS KOSZEWSKI; Fiscal Year: 2002..abstract_text> ..
- FUNCTION AND REGULATION OF THE E COLI AIDB GENESMichael Volkert; Fiscal Year: 2002..During the proposed funding period, I propose to characterize this factor further by genetic and biochemical means and to compare its induction mechanism with that of meAda. ..
- ANNEXIN PHOSPHORYLATION: CAUSES AND CONSEQUENCESCARL CREUTZ; Fiscal Year: 2004....
- FUNCTION OF THE RETINOBLASTOMA PROTEINEdward Harlow; Fiscal Year: 2002..We have finished the initial characterization of these differences and in the next round of this grant will investigate the functional differences between pRB p107 and p130 in adipogenesis and in other defined differentiation systems. ..
- Nuclease-Resistant Aptamers for Anthrax OpsonizationJohn Bruno; Fiscal Year: 2004..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
- Nuclease-Resistant Aptamers to Botox and Anthrax ToxinsJohn Bruno; Fiscal Year: 2004..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
- Mechanism of MMP gene induction in osteoarthritisBIMAL RAY; Fiscal Year: 2004..abstract_text> ..
- Identification of Imprinted Genes in Brain DevelopmentMICHAEL O NEILL; Fiscal Year: 2004..abstract_text> ..
- Development and evaluation of subunit vaccine CmeC against Campylobacter jejuniJun Lin; Fiscal Year: 2008..S. The proposed research will provide novel information on the development of effective vaccine against C. jejuni to protect public health. [unreadable] [unreadable] [unreadable]..
- FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENTClaudia Kappen; Fiscal Year: 2003..Knowledge about the interactions of genes with environmental factors will be important for designing therapeutic strategies and preventive measures against craniofacial defects. ..
- HOST IMMUNOMODULATION BY PARASITESRamaswamy Kalyanasundaram; Fiscal Year: 2004..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
- CALCIUM DEPENDENT MEMBRANE BINDING PROTEINSCARL CREUTZ; Fiscal Year: 2002....
- Improved DNA Polymerases for Genomic SequencingThomas Schoenfeld; Fiscal Year: 2008..One has been studied in detail and, as expected, it has characteristics that are expected to improve sequencing. [unreadable] [unreadable] [unreadable]..
- Epidemiology of an uropathogenic E coli clonal groupLee Riley; Fiscal Year: 2003..coli can be spread by contaminated ingestible vehicles, and use the data generated from this project to design long-term studies to better characterize risk factors associated with CgA infection. ..
- Orgin of multidrug resistant uropathogenic E. coliLee Riley; Fiscal Year: 2008..This knowledge should lead to the implementation of improved control of drug-resistant infectious diseases. ..
- Therapeutic vaccine against tuberculosisLee Riley; Fiscal Year: 2006..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
- Novel & Selective Small Molecular Inhibitors of Human Peptide DeformylaseHakim Djaballah; Fiscal Year: 2006..Indeed, the likelihood that a compound interferes with both assays, and therefore behaves as a false positive in both assays, is vastly reduced compared to a strategy solely based on one technique. ..
- HUMAN OXIDATION RESISTANCE GENESMichael Volkert; Fiscal Year: 2007..abstract_text> ..
- Middle Ear Epithelial Response to Cytokine StimulationJoseph Kerschner; Fiscal Year: 2005....
- LC/MDS TOF Spectrometer for Instrument Facility at CSURobert Williams; Fiscal Year: 2006..Finally, many of these measurements will be made in an open access environment. [unreadable] [unreadable]..
- Decidual macrophages in primate pregnancyIgor Slukvin; Fiscal Year: 2007..abstract_text> ..
- GENETICS OF CANCER AND INHERITED DISEASESEdward Harlow; Fiscal Year: 2003..These faculty are linked by their interest in cancer genetics, cancer biology human clinical genetics, and genetics of model organisms. ..
- A Genetic Approach to Virulence in C. albicansSuzanne Noble; Fiscal Year: 2007..Results from this work should enhance our understanding of fungal pathogenesis and identify novel targets for antifungal therapy. [unreadable] [unreadable]..
- Immunobiological Role of Fertilization Antigen(FA-1)RAJESH NAZ; Fiscal Year: 2007..unreadable] [unreadable]..
- MECHANISM OF SERUM AMYLOID A PROTEIN SYNTHESISBIMAL RAY; Fiscal Year: 2005..Results of these studies will improve understanding of the basic mechanisms of cellular response to inflammation and help in the development of a therapeutic regimen to control harmful effects of chronic inflammation. ..
- MECHANISM OF SERUM AMYLOID A PROTEIN SYNTHESISBIMAL RAY; Fiscal Year: 2003..abstract_text> ..
- Genetic dissection of skeletal patterningClaudia Kappen; Fiscal Year: 2006..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..