g0 phase

Summary

Summary: A quiescent state of cells during G1 PHASE.

Top Publications

  1. ncbi Cyclin C makes an entry into the cell cycle
    Julien Sage
    Departments of Pediatrics and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 6:607-8. 2004
  2. ncbi Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate
    Jonathan D Stallings
    Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Biol Chem 280:22060-9. 2005
  3. pmc A new description of cellular quiescence
    Hilary A Coller
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 4:e83. 2006
  4. ncbi Early development in utero of bovine nuclear transfer embryos using early G1 and G0 phase cells
    Atsushi Ideta
    Zen noh Embryo Transfer Center, Kamishihoro, Katogun, Hokkaido, Japan
    Cloning Stem Cells 9:571-80. 2007
  5. pmc "Sleeping beauty": quiescence in Saccharomyces cerevisiae
    Joseph V Gray
    Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, University of Glasgow, Anderson College, 56 Dumbarton Rd, Glasgow G11 6NU, United Kingdom
    Microbiol Mol Biol Rev 68:187-206. 2004
  6. ncbi RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells
    Guilin Li
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Mol Cell Biochem 350:193-200. 2011
  7. ncbi Tristetraprolin and LPS-inducible CXC chemokine are rapidly induced in presumptive satellite cells in response to skeletal muscle injury
    Chetana Sachidanandan
    Center for Cellular and Molecular Biology, Hyderabad 500 007 India
    J Cell Sci 115:2701-12. 2002
  8. pmc c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest
    Miaoqing Shen
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 284:25664-77. 2009
  9. pmc High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A
    K R Ayscough
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202, USA
    J Cell Biol 137:399-416. 1997
  10. ncbi c-Cbl interacts with CD38 and promotes retinoic acid-induced differentiation and G0 arrest of human myeloblastic leukemia cells
    Miaoqing Shen
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Cancer Res 68:8761-9. 2008

Research Grants

Detail Information

Publications233 found, 100 shown here

  1. ncbi Cyclin C makes an entry into the cell cycle
    Julien Sage
    Departments of Pediatrics and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 6:607-8. 2004
    ..In an article published recently in Cell, Ren and Rollins investigate mechanisms controlling the G0/G1 transition in quiescent cells and identify new cyclin C/Cdk3 complexes as key regulators of cell cycle reentry in human cells...
  2. ncbi Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate
    Jonathan D Stallings
    Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Biol Chem 280:22060-9. 2005
    ....
  3. pmc A new description of cellular quiescence
    Hilary A Coller
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 4:e83. 2006
    ..These studies form a basis for understanding the normal biology of cellular quiescence...
  4. ncbi Early development in utero of bovine nuclear transfer embryos using early G1 and G0 phase cells
    Atsushi Ideta
    Zen noh Embryo Transfer Center, Kamishihoro, Katogun, Hokkaido, Japan
    Cloning Stem Cells 9:571-80. 2007
    ..we examined the morphological development in utero of NT embryos using early G1 phase cells (eG1-NT embryos) and G0 phase cells (G0-NT embryos)...
  5. pmc "Sleeping beauty": quiescence in Saccharomyces cerevisiae
    Joseph V Gray
    Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, University of Glasgow, Anderson College, 56 Dumbarton Rd, Glasgow G11 6NU, United Kingdom
    Microbiol Mol Biol Rev 68:187-206. 2004
    ..Finally, we outline what is known about the process by which cells exit from quiescence when nutrients again become available...
  6. ncbi RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells
    Guilin Li
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Mol Cell Biochem 350:193-200. 2011
    ..Thus, the findings not only provide a molecular basis for the role of iASPP in cell cycle progression of glioblastoma cells but also suggest a novel therapeutic target for the treatment of GBM...
  7. ncbi Tristetraprolin and LPS-inducible CXC chemokine are rapidly induced in presumptive satellite cells in response to skeletal muscle injury
    Chetana Sachidanandan
    Center for Cellular and Molecular Biology, Hyderabad 500 007 India
    J Cell Sci 115:2701-12. 2002
    ..Our studies suggest that in addition to generating new cells for repair, activated satellite cells may be a source of signaling molecules involved in tissue remodeling during regeneration...
  8. pmc c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest
    Miaoqing Shen
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 284:25664-77. 2009
    ..The results demonstrate the importance of the Gly306 residue in the ability of c-Cbl to propel RA-induced differentiation...
  9. pmc High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A
    K R Ayscough
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202, USA
    J Cell Biol 137:399-416. 1997
    ..Finally, transient actin depolymerization caused many cells to abandon one bud site or mating projection and to initiate growth at a second site. Thus, actin filaments are also required for maintenance of an axis of cell polarity...
  10. ncbi c-Cbl interacts with CD38 and promotes retinoic acid-induced differentiation and G0 arrest of human myeloblastic leukemia cells
    Miaoqing Shen
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Cancer Res 68:8761-9. 2008
    ..There thus seems to be a cooperative role for c-Cbl and CD38, reflected in their direct binding, in propulsion of RA-induced differentiation...
  11. pmc The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest
    Xianmin Xia
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    Mol Cell Biol 23:1717-25. 2003
    ..These data demonstrate for the first time an association of p55gamma with Rb and show that modification of this association can lead to cell cycle arrest...
  12. ncbi A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells
    Hidesato Ogawa
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Science 296:1132-6. 2002
    ..The E2F-6 complex preferentially occupies target promoters in G0 cells rather than in G1 cells. These data suggest that these chromatin modifiers contribute to silencing of E2F- and Myc-responsive genes in quiescent cells...
  13. pmc Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?
    D Scott
    Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK
    Br J Cancer 77:614-20. 1998
    ..In the long term, such cytogenetic assays may have the potential for selecting women for intensive screening for breast cancer...
  14. pmc Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures
    Chris Allen
    Department of Biology, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA
    J Cell Biol 174:89-100. 2006
    ..The ability to isolate both quiescent and nonquiescent yeast cells from SP cultures provides a novel, tractable experimental system for studies of quiescence, chronological and replicative aging, apoptosis, and the cell cycle...
  15. pmc Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phase
    Mizuki Shimanuki
    G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University OIST, Onna, Okinawa, Japan
    PLoS ONE 8:e78545. 2013
    ..Klf1 thus plays a role in G0 phase longevity by enhancing the differentiation signal and suppressing metabolism for growth. If Klf1 is lost, S...
  16. pmc Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells
    K Maaser
    Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Benjamin Franklin University Hospital, Free University of Berlin, Germany
    Br J Cancer 85:1771-80. 2001
    ..Thus, our data demonstrate a functional involvement of PBR in colorectal cancer growth and qualify the PBR as a possible target for innovative therapeutic approaches in colorectal cancer...
  17. ncbi Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference
    Carsten Denkert
    1Institute of Pathology, Charite Hospital, Humboldt University, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Oncogene 22:8653-61. 2003
    ..Furthermore, our results suggest that cell cycle arrest is one of the primary mechanisms responsible for the antiproliferative effects of NS-398 on ovarian carcinoma cells...
  18. ncbi G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage
    Chris van Bree
    Academic Medical Center, Laboratory for Experimental Oncology and Radiobiology, Department of Radiation Oncology, University of Amsterdam, Amsterdam, The Netherlands
    Radiat Res 170:184-91. 2008
    ..Our data suggest that the induction of G(0) cell cycle arrest and the reduction of proliferation are not sufficient to enable PLD repair...
  19. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    ....
  20. ncbi Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation
    Jyotsna Dhawan
    Center for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
    J Cell Sci 117:3735-48. 2004
    ..We suggest that in myoblasts, the Rho pathway and regulation of acto-myosin contractility may define a control point for conditional uncoupling of differentiation and the cell cycle...
  21. pmc Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle
    S J Orr
    King s College London, Department of Haematological Medicine, Leukaemia Sciences Laboratories, Rayne Institute, London, UK
    Oncogene 29:3803-14. 2010
    ..Therefore, a simple reduction in MCM loading onto DNA, which occurs in cancers as a result of aberrant cell cycle control, is sufficient to cause PCS and gross genomic instability within one cell cycle...
  22. ncbi Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombe
    Mizuki Shimanuki
    Initial Research Project IRP, Okinawa Institute of Science and Technology Promotion Corporation OIST, Uruma 904 2234, Okinawa, Japan
    Genes Cells 12:677-92. 2007
    ....
  23. pmc Commitment point during G0-->G1 that controls entry into the cell cycle
    Nicholas C Lea
    Department of Haematological Medicine, Leukaemia Sciences Laboratories, Guy s, King s and St Thomas School of Medicine, London SE5 9NU, United Kingdom
    Mol Cell Biol 23:2351-61. 2003
    ....
  24. ncbi Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
    Allan B Dietz
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Blood 104:1094-9. 2004
    ..These findings indicate that long-term administration of high-dose imatinib mesylate might affect immunity...
  25. ncbi Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland
    J A Hutt
    Department of Veterinary Biosciences and Division of Molecular Biology and Cancer Genetics, Ohio State Comprehensive Cancer Center and the Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, 43210, USA
    J Biol Chem 275:29123-31. 2000
    ..These data indicate that Stat3 activates C/EBPdelta transcription in G(0) growth-arrested mouse mammary epithelial cells and binds to the C/EBPdelta promoter during involution. An autocrine mechanism of Stat3 activation is proposed...
  26. ncbi Acute myeloid leukemia cells in G0 phase of the cell cycle that are unresponsive to conventional chemotherapy are sensitive to treatment with granulocyte-macrophage colony-stimulating factor/diphtheria toxin fusion proteins
    Inge Jedema
    Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Hematol 32:188-94. 2004
    ..In this study we manipulated the cell cycle and proliferative status of leukemic cells, explored the effect on sensitivity to DT, and determined the ability of DT388GMCSF fusion proteins to activate and subsequently kill leukemic cells...
  27. ncbi CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation
    Sachin Mahale
    Leicester School of Pharmacy, De Montfort University, UK
    Bioorg Med Chem Lett 16:4272-8. 2006
    ..5 microM). As would be expected of a Cdk4 inhibitor that does not inhibit Cdk2, it maintains a G(0)/G(1) block in synchronised cancer cells and inhibits Cdk4-specific phosphorylation of the retinoblastoma protein...
  28. ncbi G(1)/S but not G(0)/G(1)cell fraction is related to 5-fluorouracil cytotoxicity
    J F Mirjolet
    Laboratoire de Recherche en Oncologie, Centre Alexis Vautrin, F 54511 Vandoeuvre les Nancy Cedex, France
    Cytometry 48:6-13. 2002
    ..However, results were still controversial. Moreover, we had reported that 5FU sensitivity was related to the labeling index of untreated cell cultures...
  29. ncbi The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms
    Elisabetta Cameroni
    Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, Univeristy of Geneva, Switzerland
    Cell Cycle 3:462-8. 2004
    ....
  30. ncbi CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control
    G S Sivko
    Department of Veterinary Biosciences and Division of Molecular Biology and Cancer Genetics, Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    J Cell Biochem 93:844-56. 2004
    ..These results indicate that the human C/EBPdelta gene is controlled at multiple levels, consistent with a role for C/EBPdelta in cell cycle control and/or cell fate determination...
  31. ncbi TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0
    Ivo Pedruzzi
    Department of Medical Biochemistry, CMU, University of Geneva, 1211 Geneva 4, Switzerland
    Mol Cell 12:1607-13. 2003
    ..Thus, Rim15 integrates signals from at least three nutrient-sensory kinases (TOR, PKA, and Sch9) to properly control entry into G(0), a key developmental process in eukaryotic cells...
  32. pmc Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis
    J Boer
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 18:1236-47. 1998
    ..These results confirm that CAN plays a crucial role in nucleocytoplasmic transport and imply an essential role for hCRM1 in cell growth and survival...
  33. pmc NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition
    M Hinz
    Molekulare Zellbiologie, Humboldt Universitat zu Berlin, Max Delbrück Haus, 13122 Berlin, Germany
    Mol Cell Biol 19:2690-8. 1999
    ..Thus, NF-kappaB contributes to cell cycle progression, and one of its targets might be cyclin D1...
  34. ncbi Chromosome or chromatin condensation leads to meiosis or apoptosis in stationary yeast (Saccharomyces cerevisiae) cells
    Hui Yang
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    FEMS Yeast Res 6:1254-63. 2006
    ..Cells with homogeneous nuclei are believed to be in the true resting state and undergo cell death when starvation continues. Chromosome or chromatin condensation may serve as a hallmark of life or death for stationary cells...
  35. ncbi On the proposal of a G0 phase and the restriction point
    S Cooper
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 49109 0620, USA
    FASEB J 12:367-73. 1998
    ..Cells before this point are able to leave the division cycle and enter a G0 phase; cells past this point are unaffected by a short period of low serum...
  36. ncbi Reappraisal of serum starvation, the restriction point, G0, and G1 phase arrest points
    Stephen Cooper
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    FASEB J 17:333-40. 2003
    ..It is proposed that the arrest of cells with a particular DNA content equivalent to that in cells in the G1 phase of the division cycle does not mean there is any particular G1 phase control point...
  37. ncbi Recruitment of leukemic cells from G0 phase of the cell cycle by interferons results in conversion of resistance to daunorubicin
    I Jedema
    Leukemia 17:2049-51. 2003
  38. ncbi Cyclin C/cdk3 promotes Rb-dependent G0 exit
    Shengjun Ren
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:239-51. 2004
    ..Thus, G1 entry is regulated in an analogous fashion to S phase entry, but involves a distinct cyclin/cdk combination...
  39. ncbi CD34+/CD105+ cells are enriched in primitive circulating progenitors residing in the G0 phase of the cell cycle and contain all bone marrow and cord blood CD34+/CD38low/- precursors
    L Pierelli
    Cattedra di Ematologia Istituto di Ostetricia e Ginecologia, Universita Cattolica del Sacro Cuore, Roma, Italy
    Br J Haematol 108:610-20. 2000
    ..Extensive characterization of these CD105+ precursors indicated that they have biological properties associated with primitive haematopoietic precursors...
  40. pmc Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells
    John W Tullai
    Department of Biology, Boston University, MA 02215, USA
    J Biol Chem 282:9482-91. 2007
    ..These results indicate that GSK-3 actively represses gene expression in quiescent cells, with inhibition of CREB playing a key role in this transcriptional response...
  41. ncbi SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle
    Yohannes Tesfaigzi
    Lovelace Respiratory Research Inst, 2425 Ridgecrest Dr, SE, Albuquerque, NM 87108, USA
    Am J Physiol Lung Cell Mol Physiol 285:L889-98. 2003
    ..We reported that expression of SPRR1B in Chinese hamster ovary (CHO) cells is increased as they enter the G0 phase of the cell cycle...
  42. ncbi Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK
    Ling Chi Wang
    Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, Keck School of Medicine at USC, Los Angeles, California 90033, USA
    J Biol Chem 280:7634-44. 2005
    ..Taken together, this study shows that, in vitro, TNFalpha-induced cell cycle arrest through IKK can provide a mechanism for the development of drug resistance to anti-cancer drugs, purine and pyrimidine analogues...
  43. ncbi Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells
    Xiao Nan Li
    Laboratory of Molecular Neuro Oncology, Baylor College of Medicine, 6621 Fannin Street, Houston, TX 77030, USA
    Clin Cancer Res 10:1150-9. 2004
    ..This study was undertaken to evaluate their antitumor activities in medulloblastomas...
  44. ncbi Cell cycle stage analysis of rabbit foetal fibroblasts and cumulus cells
    C T Liu
    Department of Animal Science, National ChungHsing University, Taichung, Taiwan
    Reprod Domest Anim 39:385-90. 2004
    ..Chemical synchronization of the cell cycle stage of rabbit foetal fibroblasts to G0/G1 phase appeared less effective compared to serum deprivation...
  45. ncbi Manganese chloride-induced G0/G1 and S phase arrest in A549 cells
    Peng Zhao
    Department of Toxicology, Peking University Health Science Center, Beijing 100083, China
    Toxicology 250:39-46. 2008
    ....
  46. ncbi Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032 2704, USA
    Clin Cancer Res 10:1130-40. 2004
    ..A hypothetical model explaining these two phases is presented. The diverse effects that we obtained with ACR suggest that this agent might be useful in the chemoprevention and/or therapy of human SCCs...
  47. ncbi The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation
    Mei Chi Chang
    Team of Biomedical Science, Chang Gung Institute of Technology, Kwei Shan, Taoyuan, Taiwan
    J Biol Chem 279:50676-83. 2004
    ..AN ingredients thus play a significant role in the pathogenesis of oropharyngeal cancer by activation of MEK1/ERK/c-Fos pathway, which promotes keratinocyte inflammation, cell survival, and affects cell cycle progression...
  48. pmc N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA
    Aruna S Jaiswal
    UF Shands Cancer Center and Anatomy and Cell Biology, College of Medicine, Academic Research Building, Room R4 216, PO Box 100232, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 3:3. 2004
    ..In the present study we report that the DNA-damaging agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is able to induce senescence in the HCT-116 colon cancer cell line...
  49. ncbi Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivation
    Daniela Matei
    Department of Medicine, Walther Oncology Center, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 10:681-90. 2004
    ....
  50. ncbi Trihydrophobin 1 is a new negative regulator of A-Raf kinase
    Weicheng Liu
    State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    J Biol Chem 279:10167-75. 2004
    ..Taken together, our data provide a clue to understanding the cellular function of TH1 on Raf isoform-specific regulation...
  51. ncbi Effects of serum deprivation and cycloheximide on cell cycle of low and high passage porcine fetal fibroblasts
    M D Goissis
    Laboratory of In Vitro Fertilization, Cloning and Animal Transgenesis, Department of Animal Reproduction, Faculty of Veterinary Medicine and Animal Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Reprod Domest Anim 42:660-3. 2007
    ..05). These data indicates that high passage cells in vitro are more susceptible to serum starvation and CHX G0/G1 synchronization...
  52. ncbi P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells
    Igor Oruetxebarria
    Gene Regulation Laboratory and Center for Biomedical Genetics, Leiden University Medical Center, The Netherlands
    J Biol Chem 279:3807-16. 2004
    ..Collectively, these results indicate that in human MRT cells, the p16(INK4a)/pRb, rather than the p14(ARF)/p53 pathway, mediates hSNF5-induced cellular senescence...
  53. ncbi Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells
    Girish Sharma
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Int J Oncol 23:1413-8. 2003
    ..Together, these results warrant further mechanistic and in vivo efficacy studies with IP6 in TRAMP and other pre-clinical models of PCA...
  54. ncbi Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways
    Yuan Soon Ho
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei 110, Taiwan
    Food Chem Toxicol 43:1483-95. 2005
    ..Our findings highlight the molecular mechanisms underlying the Eco-induced toxicity on colon cancer cells...
  55. ncbi Synergistic interactions between tamoxifen and trastuzumab (Herceptin)
    Athanassios Argiris
    Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06510, USA
    Clin Cancer Res 10:1409-20. 2004
    ..This suggests that targeting both receptors simultaneously may have a dramatic effect on the biology of breast cancer. This hypothesis was tested in cell culture experiments...
  56. ncbi A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes
    Chunhua Qin
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    Mol Cancer Ther 3:247-60. 2004
    ..These compounds are a novel class of synthetic PPARgamma agonists that induce responses in MCF-7 cells similar to those observed for PGJ2...
  57. ncbi The antiproliferative activity of prodelphinidin B-2 3'-O-gallate from green tea leaf is through cell cycle arrest and Fas-mediated apoptotic pathway in A549 cells
    P L Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC
    Food Chem Toxicol 43:315-23. 2005
    ..We suggested that prodelphinidin B-2 3'-O-gallate's activities might be potentially contribute to its overall chemopreventive effects against lung cancer, and can possibly be considered for future therapeutic application...
  58. ncbi The estrogen antagonist ICI-182-780 does not inhibit the transformation phenotypes induced by 17-beta-estradiol and 4-OH estradiol in human breast epithelial cells
    Mohamed H Lareef
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 26:423-9. 2005
    ....
  59. ncbi The effect of basic fibroblast growth factor on cell cycle in human gingival fibroblasts from nifedipine responder and non-responder
    Reiri Takeuchi
    Department of Pharmacology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Oral Sci 46:37-44. 2004
    ..These results indicate that nifedipine responder cells may be more susceptible to growth factors such as bFGF with a resultant increase in expression of cyclins and CDKs in responder compared with non-responder cells...
  60. ncbi Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements
    Aleksandra Isakovic
    Institute of Biochemistry, School of Medicine, University of Belgrade, Belgrade, Serbia
    Bioorg Med Chem 16:5683-94. 2008
    ....
  61. ncbi Cytotoxic activity of an octadecenoic acid extract from Euphorbia kansui (Euphorbiaceae) on human tumour cell strains
    Farong Yu
    School of Public Security, Gansu Institute of Political Science and Law, Lanzhou 730070, China
    J Pharm Pharmacol 60:253-9. 2008
    ..These observations encourage further clinical evaluation of the inhibitory effects of octadecenoic acids on various forms of cancer...
  62. ncbi Cutting edge: B7/CD28 interactions regulate cell cycle progression independent of the strength of TCR signaling
    Jody L Bonnevier
    Rheumatic Division and Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Immunol 169:6659-63. 2002
    ..However, unlike the TCR, the strength of CD28 stimulation was also shown to play a unique role in controlling the rate of cell division by T cell blasts...
  63. pmc Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2
    Akimitsu Konishi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 22:1221-30. 2008
    ..In contrast, the processing of dysfunctional telomeres by NHEJ occurred primarily in G1, being repressed in S/G2 in a cyclin-dependent kinase (CDK)-dependent manner...
  64. ncbi beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Carcinogenesis 25:1315-25. 2004
    ..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate...
  65. ncbi Phorbol myristate induces apoptosis of taxol-resistant sarcoma cells in vitro
    Zhi ping Zong
    Medical Research Institute, Division of Basic Science, Kanazawa Medical University, Uchinada machi, Ishikawa 920 0293, Japan
    Eur J Pharmacol 489:3-11. 2004
    ....
  66. ncbi Differential activation of Smads in HeLa and SiHa cells that differ in their response to transforming growth factor-beta
    Tessy T Maliekal
    Division of Cancer Biology, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, Kerala 695 014, India
    J Biol Chem 279:36287-92. 2004
    ..We report for the first time an activation, presumably independent of Smad activation, of TGF-beta-dependent MAPK within 5 min of treatment that resulted in cell cycle progression in a cervical adenocarcinoma cell line, HeLa...
  67. ncbi Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells
    Tracy K Smith
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Carcinogenesis 25:1409-15. 2004
    ..AITC inhibits proliferation of cancer cells by causing mitotic block associated with disruption of alpha-tubulin in a manner analogous to a number of chemotherapeutic agents...
  68. ncbi Saucernetin-7 isolated from Saururus chinensis inhibits proliferation of human promyelocytic HL-60 leukemia cells via G0/G1 phase arrest and induction of differentiation
    Bo Rim Seo
    College of Pharmacy, Kyung Hee University, Hoegi dong, Seoul 130 701, Korea
    Carcinogenesis 25:1387-94. 2004
    ..This is the first report demonstrating that saucernetin-7 potently inhibits the proliferation of human promyelocytic HL-60 cells via the G1 phase cell cycle arrest and differentiation induction...
  69. ncbi Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Carcinogenesis 25:1485-94. 2004
    ..Overexpression of pRb2/p130 in HCC was, therefore, suggested to be a programmed protective response of the organism to uncontrolled proliferation...
  70. ncbi A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas
    Giovanna Maria Pierantoni
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, I 80131 Naples, Italy
    Carcinogenesis 24:1861-9. 2003
    ..These results suggest a critical role played by HMGA1 rearrangements in the generation of human lipomas...
  71. ncbi [Inhibition of phosphatidylethanolamine and phosphatidylinositol synthesis, alteration of the G0 and G1 cell cycle phases and spontaneous apoptosis in lymphocytes from patients under immunosuppressive treatment]
    Claude Rampini
    Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75012 Paris
    J Soc Biol 199:279-83. 2005
    ..This susceptibility to spontaneous apoptosis seems inherent to the status of immunodeficiency itself, whatever its origin. It may be related to the inhibition of phosphatidylethanolamine synthesis in the G0 phase.
  72. ncbi Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL
    Zhaoyu Jin
    Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cell Cycle 1:82-9. 2002
    ..The results indicate that TRAIL, in combination with a HMG-CoA reductase inhibitor, may have therapeutic potential in the treatment of human cancer...
  73. ncbi Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assembly
    Anita K Gandhi
    Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901, United States
    Leuk Res 30:849-58. 2006
    ..These studies provide evidence for the mechanism of action of lenalidomide in chromosome 5 deleted hematopoietic tumors in vitro, and may provide a better understanding of the drug's activity in clinical applications...
  74. ncbi Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines
    Nikita I Ivanov
    Prostate Research Centre at Vancouver General Hospital, University of British Columbia, 2660 Oak Street, Vancouver, BC, Canada V6T 1Z4
    Clin Nutr 26:252-63. 2007
    ..Our study investigates the molecular mechanism underlying anti-cancer activity of lycopene-based products in androgen-responsive (LNCaP) and androgen-independent (PC3) cells...
  75. ncbi Effects of WR-2721 and cyclophosphamide on the cell cycle phase specificity of apoptosis in mouse bone marrow
    L Mazur
    Laboratory of Experimental Hematology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, 30 060 Cracow, Poland
    Anticancer Drugs 13:751-8. 2002
    ....
  76. ncbi NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines
    Jidong Cheng
    Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Int J Cancer 99:755-61. 2002
    ..A reduction in cell number in the S phase may be an important event in cell cycle arrest caused by NS-398 in hepatocellular carcinoma cell lines...
  77. pmc Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation
    Toru Suzuki
    Department of Oncology, Institute of Medical Science, University of Tokyo, Minato ku 108 8639, Japan
    Genes Dev 16:1356-70. 2002
    ..Thus, Tob inhibits cell growth by suppressing cyclin D1 expression, which is canceled by Erk1- and Erk2-mediated Tob phosphorylation. We propose that Tob is critically involved in the control of early G(1) progression...
  78. ncbi Molecular targets of 1,25(OH)2D3 in HC11 normal mouse mammary cell line
    Maria Lucia Hirata Katayama
    Disciplina de Oncologia do Departamento de Radiologia da Faculdade de Medicina da Universidade de São Paulo, Av Dr Arnaldo 455, 01246 903, Sao Paulo, Brazil
    J Steroid Biochem Mol Biol 84:57-69. 2003
    ..Decreased Pad1 and Ube2i might account for increased stability of cell cycle inhibitory proteins while reduced Wdnm1, Tacc3 and Scd might be secondary to accumulation of cells in G0/G1 phase...
  79. ncbi Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs
    K Dimas
    Laboratory of Pharmacology Pharmacotechnology, Foundation for Biomedical Research of the Academy of Athens, 4 Soranou Efessiou, Athens 11527, Greece
    Biomed Pharmacother 60:127-33. 2006
    ..Furthermore, sclareol enhanced the activity of known anticancer drugs, doxorubicin, etoposide and cisplatinum, against MDD2 breast cancer cell line...
  80. ncbi Cigarette tar phenols impede T cell cycle progression by inhibiting cyclin-dependent kinases
    Ashley A Frazer-Abel
    Division of Allergy and Clinical Immunology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Mol Immunol 44:488-93. 2007
    ..HQ did not affect mitogenic induction of the Cdk6 protein, but inhibited expression of cyclin D3 by >90% resulting in a dramatic reduction in proper Cdk6/Cyclin D3 complex formation...
  81. ncbi MDDD, a 4,9-diazapyrenium derivative, is selectively toxic to glioma cells by inducing growth arrest at G0/G1 independently of p53
    De Hua Yu
    Immusol Inc, 10790 Roselle Street, San Diego, CA 92121, USA
    Invest New Drugs 24:489-98. 2006
    ..These properties of MDDD favor its candidacy for evaluation as a new anti-tumor agent, particularly for glioma...
  82. ncbi Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property
    Jens M Nygren
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    J Immunol 177:201-8. 2006
    ..We propose that a uniquely prolonged cell cycle transit is a defining stem cell property, likely to be critical for their maintenance and self-renewal throughout development...
  83. ncbi p27Kip1 regulates T cell proliferation
    S Mohapatra
    Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Department of Oncology, Department of Biochemistry, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 276:21976-83. 2001
    ..We also found that cdk2 activation was both necessary and sufficient for maximal expression of cdk2 protein. These studies provide a mechanistic basis for the serum dependence of T cell mitogenesis...
  84. ncbi Beta-hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study
    M Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Hum Reprod 21:2850-6. 2006
    ..The aim of this study is to evaluate the effects of beta-HIVS on the proliferation, cell cycle and apoptosis of endometriotic stromal cells...
  85. ncbi Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
    Pelle Håkansson
    Department of Medical Biochemistry and Biophysics, Umea University, SE 90187 Umea, Sweden
    J Biol Chem 281:7834-41. 2006
    ....
  86. ncbi [Growth inhibition of MG-63 cells by cyclin A2 gene-specific small interfering RNA]
    Ye Liu
    Department of Orthopaedics, Sir Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
    Zhonghua Yi Xue Za Zhi 87:627-33. 2007
    ..To study the impact of small interference RNA (siRNA) targeting cyclin A2 gene on the growth of MG-63 and HSF cells and to explore whether cyclin A2 siRNAs could become a useful tool in the treatment of osteosarcoma...
  87. ncbi Effect of long-term CCK blockade on the pancreatic acinar cell renewal in rats with acute pancreatitis
    Ana M de la Mano
    Department of Physiology and Pharmacology, University of Salamanca, 37008 Salamanca, Spain
    Peptides 24:535-41. 2003
    ..Our results indicate that the renewal of acinar cells deleted by apoptosis 48h after BPDO worsens if CCK is blocked before inducing AP...
  88. ncbi VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression
    Seung Hyun Han
    Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305 333, Republic of Korea
    Oncogene 22:4035-46. 2003
    ..VDUP1 itself suppressed IL-3 receptor and cyclin A2 promoter activity. Taken together, these results suggest that VDUP1 is a novel antitumor gene which forms a transcriptional repressor complex...
  89. ncbi Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides
    Laurence Quemeneur
    Laboratoire d Immunopharmacologie, Institut National de la Santé et de la Recherche Médicale Unité 503, Centre d Etudes et de Recherche en Virologie et Immunologie, Institut Fédératif de Recherche 128 BioSciences Lyon Gerland, France
    J Immunol 170:4986-95. 2003
    ..These findings reveal a hitherto unknown role of purine and pyrimidine de novo synthesis in regulating cell cycle progression and maintaining survival of activated T lymphocytes...
  90. ncbi A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
    James Turkson
    Molecular Oncology and Drug Discovery Programs, H Lee Moffitt Cancer Center and Research Institute, Orlando, FL 32826, USA
    J Biol Chem 280:32979-88. 2005
    ..This study represents a significant advance in small molecule-based approaches to target Stat3 and suggests potential new applications for platinum (IV) complexes as modulators of the Stat3 pathway for cancer therapy...
  91. pmc Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen
    Steven J Wall
    Division of Hematology Oncology and Department of Pediatrics, University of Southern California and the Saban Research Institute of Childrens Hospital, Los Angeles, California 90027, USA
    J Biol Chem 280:40187-94. 2005
    ..Our data provide evidence for a novel direct mechanism by which cell contact with fibrillar collagen restricts proliferation...
  92. ncbi Tetrazolium violet induces G0/G1 arrest and apoptosis in brain tumor cells
    Yunfeng Zhao
    School of Life Science, Shandong University, Jinan 250100, China
    J Neurooncol 77:109-15. 2006
    ..Although detailed mechanisms remain to be explored, selective blockage of tumor cells in G0/G1 phase accompanied by p53-associated apoptosis makes tetrazolium violet a promising anticancer agent, meriting further investigations...
  93. ncbi Evidence of increased DNA content of murine thymocytes caused by cocaine
    Yu Bin Wu
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA
    Immunopharmacol Immunotoxicol 25:53-64. 2003
    ....
  94. ncbi Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells
    Daniela E Marin
    INCDBNA, National Research and Development Institut for Biology and Animal Nutrition, Balotesti, Romania
    Mol Nutr Food Res 51:1406-12. 2007
    ..In conclusion, these data suggest that FB1 may affect immune functions by inhibiting lymphocyte proliferation and IL2 production, suggesting a possible role of FB1 exposure during infectious disease and cancer...
  95. ncbi The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells
    Yun Ok Park
    Department of Food Science and Biotechnology, School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151 742, Korea
    Biofactors 23:129-39. 2005
    ..In the Comet assay, lycopene-treated cells showed less DNA damage than did placebo-treated cells. The inhibition of Hep3B cell growth in this study demonstrates the antitumor properties of lycopene...
  96. pmc Role of Kir4.1 channels in growth control of glia
    Haruki Higashimori
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Glia 55:1668-79. 2007
    ..1 causes a membrane hyperpolarization that is sufficient to account for the growth attenuation, which in turn induces cell maturation characterized by a shift of the cells from G2/M into G0/G1...
  97. ncbi A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia
    Ming Jer Huang
    Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    Exp Hematol 34:1480-9. 2006
    ..Inhibition of the c-Myc/Max heterodimerization by the recently identified small-molecule compound, 10058-F4, might be a novel antileukemic strategy...
  98. ncbi Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice
    Bo Kuan Wu
    Faculty of Life Sciences and Institute of Genetics, National Yang Ming University, Taipei, Taiwan
    Biochem Biophys Res Commun 340:916-28. 2006
    ....
  99. ncbi Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita University, Hasama machi, Oita, Japan
    Mol Hum Reprod 11:817-23. 2005
    ..Caspase-9-mediated cascade is involved in this mechanism. Therefore, bufalin could be used as a therapeutic agent for the treatment of endometriosis...
  100. ncbi Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma
    Vahdettin Bayazit
    Department of Biology, Faculty of Science and Arts, University of Dumlupinar, Kutahya, Turkey
    Saudi Med J 25:156-63. 2004
    ..To study, the cytotoxic effects of some biological and chemical agents on G1, S, G2, M and G0 phases of liver and colon carcinomas and myosarcoma cells obtained with chemical carcinogens dimethylbenzanthracene (DMBA) and cadmium chloride...
  101. ncbi In multiple myeloma, circulating hyperdiploid B cells have clonotypic immunoglobulin heavy chain rearrangements and may mediate spread of disease
    L M Pilarski
    Department of Oncology, University of Alberta, Edmonton, Canada
    Clin Cancer Res 6:585-96. 2000
    ..G2-M, suggesting that hyperdiploid in MM may represent a transient S-phase arrest rather than an aneuploid G0 phase. The DNA hyperdiploidy of CD34+ clonotypic B cells suggests these cells may be clinically important constituents ..

Research Grants45

  1. E1A Oncoprotein Induced Deregulation of Replication Origin Firing
    Bayar Thimmapaya; Fiscal Year: 2012
    ..an upstream YY1 binding site to keep c-Myc in a repressed state and that this contributes to maintaining cells in G0 phase. E1A induces c-Myc by interfering with this mechanism...
  2. Dual role of IL-16 in dysregulated growth of CTCL cells
    William W Cruikshank; Fiscal Year: 2012
    ..T cell growth through extracellular association with CD4, promoting CD25 expression and transition from the G0 phase to G1...
  3. Assessment of Tumor Early Response to Treatment by Diffusion MRI
    Junzhong Xu; Fiscal Year: 2013
    ..doubled copies of DNA contents and organelles in M phase (4n);and 3) cells arrested in pre-apoptotic states - sub-G0 phase (2n)...
  4. CELL CYCLE-DEPENDENT REGULATION OF MYOGENESIS
    STEPHEN SKAPEK; Fiscal Year: 1999
    ..which initiates terminal differentiation in skeletal myoblasts may be one which causes cells to arrest in the G0 phase of the cell cycle...
  5. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2006
    ..We have shown, in tissue culture, that retinoids inhibit the growth of HBE cells, which accumulate in the G0 phase of the cell cycle...
  6. FLUORESCENCE ACTIVATED CELL SORTER
    Andrew Yen; Fiscal Year: 2004
    ..The instrument requested is a Dako-Cytomation basic MoFlo plus a UV-vis, vis, and HeNe laser to provide independent UV, vis/488, and red excitation. ..
  7. TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATION
    Andrew Yen; Fiscal Year: 2003
    ..Andrew Yen, who brings expertise on the molecular and cellular biology of retinoic acid-induced myeloid differentiation. ..
  8. Retinoic Acid Regulated Cell Differentiation: BLR1 Rcptr
    Andrew Yen; Fiscal Year: 2005
    ..It has the implication that the ultimate effects of RA can be governed by relevant growth factors signaling through their cognate receptors. ..
  9. Ceramide in angiogenic integrin signaling
    Anat Erdreich Epstein; Fiscal Year: 2006
    ....
  10. Evaluate the antiangiogenic properties of mda-7/IL-24
    Rajagopal Ramesh; Fiscal Year: 2006
    ..abstract_text> ..
  11. Cs-137 Irradiator for new Fitzsimons Campus
    David Raben; Fiscal Year: 2007
    ..The JL 81 irradiator is an important component of this foundation of cancer research and will facilitate the preclinical experiments necessary for translation at the new UCDHSC Fitzsimons campus. [unreadable] [unreadable] [unreadable]..
  12. THE ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2007
    ..We will also determine whether SPARC's regulation of the phenotypes results from differences in cellular versus extracellular localization. ..
  13. PKC ISOZYMES AND INTESTINAL EPITHELIAL GROWTH CONTROL
    Jennifer Black; Fiscal Year: 2009
    ..abstract_text> ..
  14. p53 loss in HMECs: a model of breast cancer prevention
    Victoria Seewaldt; Fiscal Year: 2007
    ..abstract_text> ..
  15. Characterization of cell clones resistant to HIV
    Richard Sutton; Fiscal Year: 2007
    ..At the completion of these investigations, a well-characterized panel of cell lines will be freely available to perform more detailed biochemical or genetic complementation studies. [unreadable] [unreadable] [unreadable]..
  16. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2007
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides, therapeutic interventions, ..
  17. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2008
    ..abstract_text> ..
  18. Stem cell manipulation via HOX gene regulation
    Stephen G Emerson; Fiscal Year: 2010
    ..These experiments will describe in detail the role of NF-Y in the biology of hematopoietic stem cells, and will develop two experimental therapies based directly on the biology of NF-Y, for both HSC expansion and HSC differentiation. ..
  19. ECM-Mediated Apoptosis in p53 (-) HMECs
    Victoria L Seewaldt; Fiscal Year: 2010
    ..Significance: Completions of these aims will provide insight into early events in ER(-) mammary carcinogenesis and provide novel targets for breast cancer chemoprevention. ..
  20. TYROSINE PHOSPHATASES IN ENDOTHELIAL GROWTH CONTROL
    Takamune Takahashi; Fiscal Year: 2009
    ..These complementary efforts will identify a novel pathway that regulates endothelial cell growth through CD148 and promise new strategies for anti-angiogenesis therapy. ..
  21. Extrinsic Modulation of Hematopoietic Stem Cell Fate
    Edward F Srour; Fiscal Year: 2010
    ..These studies are critical for assessing the impact of the interaction of stem cells with their hematopoietic microenvironment on stem cell function throughout ontogeny. ..
  22. Role of RecQ Helicases to Prevent Senescence By c-Myc
    Carla Grandori; Fiscal Year: 2010
    ..If so, drug inhibitors of WRN function could be proposed for the treatment of cancer. ..
  23. A compendium of gene expression in stationary phase
    Margaret Werner Washburne; Fiscal Year: 2005
    ..parent abstract not available ..
  24. ROLE OF THE FAS ANTIGEN IN OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2004
    ..Understanding pathways that promote or prevent susceptibility of ovarian cells to apoptosis may lead to development of novel therapies for ovarian and other cancers. ..
  25. ENDOTOXIN INDUCED MUCOUS CELL METAPLASIA
    Yohannes Tesfaigzi; Fiscal Year: 2003
    ..abstract_text> ..
  26. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
    ..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
  27. STATS in Bryostatin 1 induced differentiation of CLL
    Traci Battle; Fiscal Year: 2003
    ..particularly when combined with other antileukemia drugs. ..
  28. ADHESION ANALYSIS OF CYCLING STEM CELLS THROUGH ONTOGENY
    EDWARD SROUR; Fiscal Year: 2002
    ..Examination of these goals will contribute to our understanding of normal hematopoiesis and the mechanisms that govern homing of HSC and engraftment potential of candidate populations of stem cells. ..
  29. DIRECT TARGET GENES OF THE MYC ONCOPROTEIN
    Carla Grandori; Fiscal Year: 2002
    ..These studies will provide several pieces of the puzzle necessary to understand how Myc functions as an oncogene. ..
  30. FASEB Summer Conference, July 20-25, 2002
    Fuyuhiko Tamanoi; Fiscal Year: 2002
    ..Our unique focus on lipid rafts and their significance in signal transduction as well as focus on cancer therapy and anti-parasite strategies promises to bring together a wide range of researchers. ..
  31. A TWO-HYBRID SYSTEM FOR USE IN NON-DIVIDING YEAST CELL
    Margaret Werner Washburne; Fiscal Year: 2002
    ..Once established for yeast, this method should be useful in a broad range of cell types to facilitate the genomic-scale analysis of protein-protein interactions during all phases of growth. ..
  32. Identification of Host Factor(s) Involved in HIV Release
    Richard Sutton; Fiscal Year: 2004
    ..At the completion of these studies it is hoped that a better understanding of the host factors involved in HIV release will be achieved. ..
  33. TRANSCRIPTIONAL INDUCTION BY THE HUMAN HMG 14 PROTEIN
    Ulla Hansen; Fiscal Year: 2001
    ..Together, these studies should define and characterize a novel mechanism for mediating transcriptional induction by reconfiguring the structure of chromatin at specific genes. ..
  34. Common Muscle, Hematopoietic and Neural Stem Cells
    EDWARD SROUR; Fiscal Year: 2004
    ....
  35. Linking folate deficiency to changes in gene expression
    KAREN KATULA; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  36. CORE CENTERS OF EXCELLENCE IN MOLECULAR HEMATOLOGY
    EDWARD SROUR; Fiscal Year: 2004
    ..Together the CCEMH represent a logical assembly of cores needed to continue the basic work in progress and to put in place support which we believe will be needed over the next 5 years. ..
  37. eNOS Promoter Activation by Estrogen in Vascular Cells
    Ulla Hansen; Fiscal Year: 2004
    ....
  38. T lymphocyte growth regulation by prointerleukin-16
    Kevin Wilson; Fiscal Year: 2005
    ..Such an environment maximizes the potential for the principle investigator to establish a scientific niche from which an academic career can be constructed. ..
  39. Molecular markers of breast cancer risk and prevention
    Victoria L Seewaldt; Fiscal Year: 2010
    ....
  40. LSF AND MAMMALIAN CELL CYCLE PROGRESSION
    Ulla Hansen; Fiscal Year: 2004
    ..Is LSF a major target of cdk2 (or another pathway) in progression of cells into S? 4. Does LSF critically regulate genes other than TS during cell cycle progression? ..
  41. Antigen Presenting Cells in the Induction of GVHD
    Yi Zhang; Fiscal Year: 2008
    ..abstract_text> ..
  42. STATs as a Novel Approach to Cancer Therapy
    James Turkson; Fiscal Year: 2009
    ..The proposed studies will refine and further develop lead compounds as potent Stat3 inhibitors with antitumor activities for eventual clinical applications ..
  43. White Matter Change and CNS Process in the Elderly
    Lisa Silbert; Fiscal Year: 2008
    ..This application proposes a structured didactic mentorship program for the principal investigator, Dr. Lisa Silbert, to ensure her independence as a clinical investigator at the end of the 5-year award period. [unreadable] [unreadable]..