Genomes and Genes
Summary: Formation of an acetyl derivative. (Stedman, 25th ed)
Publications332 found, 100 shown here
- Combinatorial patterns of histone acetylations and methylations in the human genomeZhibin Wang
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 40:897-903. 2008..Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation...
- Lysine acetylation targets protein complexes and co-regulates major cellular functionsChunaram Choudhary
Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
Science 325:834-40. 2009Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles...
- Translating the histone codeT Jenuwein
Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
Science 293:1074-80. 2001....
- Regulation of cellular metabolism by protein lysine acetylationShimin Zhao
School of Life Sciences, Fudan University, Shanghai 20032, China
Science 327:1000-4. 2010Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators...
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanKonrad T Howitz
BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
Nature 425:191-6. 2003..We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators...
- Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseAnne Brunet
Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
Science 303:2011-5. 2004..Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance...
- Resveratrol improves health and survival of mice on a high-calorie dietJoseph A Baur
Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 444:337-42. 2006..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
- HDAC6 is a microtubule-associated deacetylaseCharlotte Hubbert
Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
Nature 417:455-8. 2002Reversible acetylation of alpha-tubulin has been implicated in regulating microtubule stability and function. The distribution of acetylated alpha-tubulin is tightly controlled and stereotypic...
- Histone deacetylases (HDACs): characterization of the classical HDAC familyAnnemieke J M de Ruijter
Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
Biochem J 370:737-49. 2003..modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetylation is probably the best understood of these modifications: hyperacetylation leads to an increase in ..
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityCarles Canto
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
Nature 458:1056-60. 2009..The AMPK-induced SIRT1-mediated deacetylation of these targets explains many of the convergent biological effects of AMPK and SIRT1 on energy metabolism...
- Lysine acetylation: codified crosstalk with other posttranslational modificationsXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC H3A1A1, Canada
Mol Cell 31:449-61. 2008Lysine acetylation has emerged as a major posttranslational modification for histones...
- Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseS Imai
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 403:795-800. 2000..These findings provide a molecular framework of NAD-dependent histone deacetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes...
- Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genesZhibin Wang
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 138:1019-31. 2009Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive ..
- Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activationXiaolei Qiu
Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
Cell Metab 12:662-7. 2010..Our studies identify a defense program that CR provokes to reduce oxidative stress and suggest approaches to combat aging and oxidative stress-related diseases...
- miR-34a repression of SIRT1 regulates apoptosisMunekazu Yamakuchi
Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 105:13421-6. 2008..Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway...
- Acetylation of non-histone proteins modulates cellular signalling at multiple levelsStephanie Spange
Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
Int J Biochem Cell Biol 41:185-98. 2009This review focuses on the posttranslational acetylation of non-histone proteins, which determines vital regulatory processes...
- Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complexX Nan
Institute of Cell and Molecular Biology, University of Edinburgh, UK
Nature 393:386-9. 1998..The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2...
- Histone H4-K16 acetylation controls chromatin structure and protein interactionsMichael Shogren-Knaak
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 311:844-7. 2006b>Acetylation of histone H4 on lysine 16 (H4-K16Ac) is a prevalent and reversible posttranslational chromatin modification in eukaryotes...
- The many roles of histone deacetylases in development and physiology: implications for disease and therapyMichael Haberland
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Nat Rev Genet 10:32-42. 2009..Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease...
- Substrate and functional diversity of lysine acetylation revealed by a proteomics surveySung Chan Kim
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 23:607-18. 2006b>Acetylation of proteins on lysine residues is a dynamic posttranslational modification that is known to play a key role in regulating transcription and other DNA-dependent nuclear processes...
- Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancerMario F Fraga
Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Nat Genet 37:391-400. 2005..Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells...
- The transcriptional coactivators p300 and CBP are histone acetyltransferasesV V Ogryzko
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
Cell 87:953-9. 1996..p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF...
- Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timingOliver Bell
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Nat Struct Mol Biol 17:894-900. 2010..Together, these findings indicate that differential histone-modification patterns and the organization of replication have distinct and measurable effects on the exposure of the DNA template...
- SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylationMatthew D Hirschey
Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
Nature 464:121-5. 2010..Sirtuin 3 (SIRT3) is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2 (refs 1, 2)...
- Suppression of inflammation by a synthetic histone mimicEdwige Nicodeme
Centre de Recherche GSK, 27 Avenue du Québec, 91140 Villebon Sur Yvette, France
Nature 468:1119-23. 2010..Our findings suggest that synthetic compounds specifically targeting proteins that recognize post-translationally modified histones can serve as a new generation of immunomodulatory drugs...
- Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogenC J Phiel
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA
J Biol Chem 276:36734-41. 2001..Based on these observations, we propose that inhibition of histone deacetylase provides a mechanism for valproic acid-induced birth defects and could also explain the efficacy of valproic acid in the treatment of bipolar disorder...
- Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainW Gu
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
Cell 90:595-606. 1997..Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro...
- Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's diseaseTiago Fleming Outeiro
Alzheimer s Research Unit, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129, USA
Science 317:516-9. 2007..Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging...
- HATs and HDACs: from structure, function and regulation to novel strategies for therapy and preventionX J Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
Oncogene 26:5310-8. 2007b>Acetylation of the epsilon-amino group of a lysine residue was first discovered with histones in 1968, but the responsible enzymes, histone acetyltransferases and deacetylases, were not identified until the mid-1990s...
- Histone deacetylase inhibitors in cancer therapyAndrew A Lane
Massachusetts General Hospital Cancer Center, Boston, MA 02214, USA
J Clin Oncol 27:5459-68. 2009Epigenetic processes are implicated in cancer causation and progression. The acetylation status of histones regulates access of transcription factors to DNA and influences levels of gene expression...
- Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic fluxQijun Wang
State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
Science 327:1004-7. 2010Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown...
- O-acetylation of Arabidopsis hemicellulose xyloglucan requires AXY4 or AXY4L, proteins with a TBL and DUF231 domainSascha Gille
Energy Biosciences Institute, University of California, Berkeley, California 94720, USA
Plant Cell 23:4041-53. 2011..mass profiling, two nonallelic mutants (axy4-1 and axy4-2) that have a 20 to 35% reduction in xyloglucan O-acetylation were identified...
- Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcriptionMichael J Carrozza
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Cell 123:581-92. 2005..Rco1 and Eaf3 were subunits specific to Rpd3S. Mutants of RCO1 and EAF3 exhibited increased acetylation in the FLO8 and STE11 open reading frames (ORFs) and the appearance of aberrant transcripts initiating within ..
- Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylationYutaka Kondo
Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Nat Genet 40:741-50. 2008..These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation...
- Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stressRanda Tao
Howard Hughes Medical Institute and Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
Mol Cell 40:893-904. 2010..deacetylation (lenti-MnSOD(K122-R)), increased MnSOD activity when expressed in MnSOD⁻/⁻ MEFs, suggesting acetylation directly regulates function...
- Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4Michiel Vermeulen
Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
Cell 131:58-69. 2007..Interestingly, asymmetric dimethylation of H3R2 selectively inhibits TFIID binding to H3K4me3, whereas acetylation of H3K9 and H3K14 potentiates TFIID interaction...
- A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasisBong Hyun Ahn
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:14447-52. 2008..We further demonstrate that mitochondrial protein acetylation is markedly elevated in Sirt3(-/-) tissues...
- Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesionTom Rolef Ben-Shahar
Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln sInn Fields, London WC2A 3PX, UK
Science 321:563-6. 2008..We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and ..
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Joseph T Rodgers
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 434:113-8. 2005..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
- Acetylation and deacetylation of non-histone proteinsMichele A Glozak
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 23011, Tampa, FL 33612, USA
Gene 363:15-23. 2005..by histone deacetylases (HDACs) opens yet another exciting new field of discovery in the role of the dynamic acetylation and deacetylation on cellular function...
- Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivationQiHuang Jin
Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
EMBO J 30:249-62. 2011..Here, we show deletion of GCN5/PCAF in cells specifically and dramatically reduces acetylation on histone H3K9 (H3K9ac) while deletion of CBP/p300 specifically and dramatically reduces acetylations on H3K18 ..
- Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growthLei Lv
Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University, Shanghai 200032, China
Mol Cell 42:719-30. 2011..Here we show that PKM2 is acetylated on lysine 305 and that this acetylation is stimulated by high glucose concentration...
- SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life spanTiara L A Kawahara
Program in Epithelial Biology, Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 136:62-74. 2009..We propose that SIRT6 attenuates NF-kappaB signaling via H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling may contribute to premature and normal aging...
- A molecular determinant for the establishment of sister chromatid cohesionElcin Unal
Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA
Science 321:566-9. 2008..Smc3p acetylation is induced in S phase after the chromatin loading of cohesin and is suppressed in G(1) and G(2)/M...
- Acetylation of tau inhibits its degradation and contributes to tauopathySang Won Min
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Neuron 67:953-66. 2010..We found that tau is acetylated and that tau acetylation prevents degradation of phosphorylated tau (p-tau)...
- CBP/p300-mediated acetylation of histone H3 on lysine 56Chandrima Das
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
Nature 459:113-7. 2009b>Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast...
- Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeastJinglan Zhang
Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell 31:143-51. 2008..Our study thus identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion.
- Altered histone acetylation is associated with age-dependent memory impairment in miceShahaf Peleg
Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
Science 328:753-6. 2010..During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation...
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisDohoon Kim
Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA
EMBO J 26:3169-79. 2007..resveratrol reduced neurodegeneration in the hippocampus, prevented learning impairment, and decreased the acetylation of the known SIRT1 substrates PGC-1alpha and p53...
- Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosisYi Tang
Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
Mol Cell 24:827-39. 2006..we show that Tip60 is required for both cell growth arrest and apoptosis mediated by p53 and also induces its acetylation specifically at lysine 120 (K120) within the DNA-binding domain...
- Loss-of-function mutation of REDUCED WALL ACETYLATION2 in Arabidopsis leads to reduced cell wall acetylation and increased resistance to Botrytis cinereaYuzuki Manabe
Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Plant Physiol 155:1068-78. 2011..However, the enzymes involved in the polysaccharide acetylation have not been identified...
- Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5Christine Schlicker
Laboratory of Biochemistry, Department of Physiological Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801 Bochum, Germany
J Mol Biol 382:790-801. 2008....
- Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylationDavid B Lombard
Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 27:8807-14. 2007..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in ..
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesJill C Milne
Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
Nature 450:712-6. 2007..Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes...
- CREBBP mutations in relapsed acute lymphoblastic leukaemiaCharles G Mullighan
Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nature 471:235-9. 2011..Functionally, the mutations impaired histone acetylation and transcriptional regulation of CREBBP targets, including glucocorticoid responsive genes...
- Acetylation is indispensable for p53 activationYi Tang
Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell 133:612-26. 2008..conflicting reports on the question of whether p53 posttranslational modifications, such as phosphorylation or acetylation, are essential or only play a subtle, fine-tuning role in the p53 response...
- p53 post-translational modification: deregulated in tumorigenesisChao Dai
Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
Trends Mol Med 16:528-36. 2010....
- Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapSean R Collins
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
Nature 446:806-10. 2007..Rtt109 is the founding member of a novel class of histone acetyltransferases responsible for Asf1-dependent acetylation of histone H3 on lysine 56...
- Regulation of histone acetylation during memory formation in the hippocampusJonathan M Levenson
Baylor College of Medicine, Department of Neuroscience, Houston, Texas 77030, USA
J Biol Chem 279:40545-59. 2004..Specifically, we investigated hippocampal histone acetylation during the initial stages of consolidation of long term association memories in a contextual fear conditioning ..
- Histone acetylation in chromatin structure and transcriptionM Grunstein
Department of Biological Chemistry, UCLA School of Medicine and the Molecular Biology Institute, University of California, Los Angeles 90095, USA
Nature 389:349-52. 1997..These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genes.
- HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptorJeffrey J Kovacs
Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
Mol Cell 18:601-7. 2005..Here, we present evidence that Hsp90 chaperone activity is regulated by reversible acetylation and controlled by the deacetylase HDAC6. We show that HDAC6 functions as an Hsp90 deacetylase...
- Recovery of learning and memory is associated with chromatin remodellingAndre Fischer
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 447:178-82. 2007..Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation)...
- Duration of nuclear NF-kappaB action regulated by reversible acetylation- Chen Lf
Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, CA 94141, USA
Science 293:1653-7. 2001..Our studies now demonstrate that the RelA subunit of NF-kappaB is subject to inducible acetylation and that acetylated forms of RelA interact weakly, if at all, with IkappaBalpha...
- ATP-citrate lyase links cellular metabolism to histone acetylationKathryn E Wellen
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 324:1076-80. 2009Histone acetylation in single-cell eukaryotes relies on acetyl coenzyme A (acetyl-CoA) synthetase enzymes that use acetate to produce acetyl-CoA...
- Histone modifications in transcriptional regulationShelley L Berger
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Curr Opin Genet Dev 12:142-8. 2002..to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues ..
- Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activityBenjamin D Rowland
University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
Mol Cell 33:763-74. 2009..According to this model, Eco1 promotes sister DNA entrapment partly by relieving an antiestablishment activity associated with Scc3, Pds5, and Rad61...
- Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylationChuanbing Bian
School of Life Sciences, University of Science and Technology of China, Anhui, People s Republic of China
EMBO J 30:2829-42. 2011..Our in vitro and in vivo functional assays show that Sgf29 recognizes methylated H3K4 to recruit the SAGA complex to its targets sites and mediates histone H3 acetylation, underscoring the importance of Sgf29 in gene regulation.
- Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylationStephen J Haggarty
Department of Molecular and Cellular Biology, and Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 100:4389-94. 2003Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment of cancer...
- N-terminal acetylation of cellular proteins creates specific degradation signalsCheol Sang Hwang
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Science 327:973-7. 2010..Removal of N-terminal Met by Met-aminopeptidases frequently leads to Nt-acetylation of the resulting N-terminal alanine (Ala), valine (Val), serine (Ser), threonine (Thr), and cysteine (Cys) ..
- Histone H4 lysine 16 acetylation regulates cellular lifespanWeiwei Dang
Gene Expression and Regulation Program, The Wistar Institute Philadelphia, Pennsylvania 19104, USA
Nature 459:802-7. 2009..of the family to be found, establishes and maintains chromatin silencing by removing histone H4 lysine 16 acetylation and bringing in other silencing proteins...
- Covalent modifications of histones during development and disease pathogenesisSukesh R Bhaumik
Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
Nat Struct Mol Biol 14:1008-16. 2007..and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation...
- Sirtuins deacetylate and activate mammalian acetyl-CoA synthetasesWilliam C Hallows
Department of Biomolecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 103:10230-5. 2006..We demonstrate that mammalian Acetyl-CoA synthetases (AceCSs) are regulated by reversible acetylation and that sirtuins activate AceCSs by deacetylation...
- Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2Bjoern Schwer
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 103:10224-9. 2006..that a mammalian sirtuin directly controls the activity of a metabolic enzyme by means of reversible lysine acetylation. Because the activity of a bacterial ortholog of AceCS2, called ACS, is controlled via deacetylation by a ..
- TRIM24 links a non-canonical histone signature to breast cancerWen Wei Tsai
Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nature 468:927-32. 2010..The PHD-Bromo of TRIM24 provides a structural rationale for chromatin activation through a non-canonical histone signature, establishing a new route by which chromatin readers may influence cancer pathogenesis...
- HDAC-6 interacts with and deacetylates tubulin and microtubules in vivoYu Zhang
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
EMBO J 22:1168-79. 2003..Reversible acetylation on the epsilon-amino group of alpha-tubulin Lys40 marks stabilized microtubule structures and may contribute to ..
- HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylationP Gaub
Center for Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany
Cell Death Differ 17:1392-408. 2010Neuronal outgrowth is guided by both extrinsic and intrinsic factors, involving transcriptional regulation. The acetylation of histones and transcription factors, which facilitates promoter accessibility, ultimately promotes ..
- Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neuronsKoichi Hasegawa
Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Osaka 565 0871, Japan
J Neurosci 28:8772-84. 2008..Here we report that necdin regulates the acetylation status of p53 via Sirt1 to suppress p53-dependent apoptosis in postmitotic neurons...
- Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65Rosemary Kiernan
Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, Montpellier 34296, France
J Biol Chem 278:2758-66. 2003..Both HDAC2 and HDAC3 interact with p65, although only HDAC3 was able to deacetylate p65. Acetylation of p65 reduces its ability to bind kappaBeta-DNA...
- Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in DrosophilaJ S Steffan
Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
Nature 413:739-43. 2001..These findings raise the possibility that therapy with HDAC inhibitors may slow or prevent the progressive neurodegeneration seen in Huntington's disease and other polyglutamine-repeat diseases, even after the onset of symptoms...
- Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normallyYu Zhang
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, P O Box 2543, Maulbeerstrasse 66, 4058 Basel, Switzerland
Mol Cell Biol 28:1688-701. 2008..To investigate the in vivo functions of HDAC6 and the relevance of tubulin acetylation/deacetylation, we targeted the HDAC6 gene by homologous recombination in embryonic stem cells and generated ..
- Acetylation of the p53 DNA-binding domain regulates apoptosis inductionStephen M Sykes
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Mol Cell 24:841-51. 2006..This modification, acetylation of lysine 120 (K120), occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases ..
- An acetylation site in the middle domain of Hsp90 regulates chaperone functionBradley T Scroggins
Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Mol Cell 25:151-9. 2007..Hsp90 is subject to an array of posttranslational modifications that affect its function, including acetylation. Histone deacetylase (HDAC) inhibitors and knockdown of HDAC6 induce Hsp90 acetylation and inhibit its activity...
- The genomic landscape of histone modifications in human T cellsTae Young Roh
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:15782-7. 2006..Our data reveal that rapidly inducible genes are associated with the H3 acetylation and H3K4me3 modifications, suggesting they assume a chromatin structure poised for activation...
- C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaBSonja I Gringhuis
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Immunity 26:605-16. 2007..trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1, which subsequently leads to acetylation of the NF-kappaB subunit p65, but only after TLR-induced activation of NF-kappaB...
- SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70Nagalingam R Sundaresan
University of Chicago Medical Center, Committee on Cellular and Molecular Physiology, Biological Science Division, University of Chicago, Chicago, Illinois 60637, USA
Mol Cell Biol 28:6384-401. 2008..These studies underscore an essential role of SIRT3 in the survival of cardiomyocytes in stress situations...
- Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexP A Grant
Department of Biochemistry and Molecular Biology and The Center for Gene Regulation, The Pennsylvania State University, University Park 16802 4500, USA
Genes Dev 11:1640-50. 1997..it fails to acetylate histones contained in nucleosomes, indicating that additional components are required for acetylation of chromosomal histones...
- SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body productionTadahiro Shimazu
Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
Cell Metab 12:654-61. 2010..Our findings show SIRT3 regulates ketone body production during fasting and provide molecular insight into how protein acetylation can regulate enzymatic activity.
- FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA inductionYukari Ido Kitamura
Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
Cell Metab 2:153-63. 2005..Using acetylation-defective and acetylation-mimicking mutants, we demonstrate that acetylation targets FoxO1 to Pml and prevents ..
- HDAC6 a new cellular stress surveillance factorPatrick Matthias
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
Cell Cycle 7:7-10. 2008..HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses...
- Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assemblyFelizza Q Gunderson
Department of Biology, Molecular Biology Section, University of California San Diego, La Jolla, California, USA
PLoS Genet 5:e1000682. 2009..of defective transcription elongation for these genes in the absence of Gcn5, while Gcn5-dependent histone acetylation is enriched in the promoter regions...
- MEC-17 is an alpha-tubulin acetyltransferaseJyothi S Akella
Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA
Nature 467:218-22. 2010..b>Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that ..
- Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genesDiego Pasini
Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
Nucleic Acids Res 38:4958-69. 2010..We show that loss of PRC2 activity results in a global increase in H3K27 acetylation. The methylation to acetylation switch correlates with the transcriptional activation of PcG target genes, both ..
- Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's diseaseEmma Hockly
Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, Eighth Floor Guy s Tower, Guy s Hospital, London SE1 9RT, United Kingdom
Proc Natl Acad Sci U S A 100:2041-6. 2003..We show that SAHA crosses the blood-brain barrier and increases histone acetylation in the brain...
- Multiple roles of HDAC inhibition in neurodegenerative conditionsDe Maw Chuang
Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, 10 Center Drive MSC 1363, Bethesda, MD 20892 1363, USA
Trends Neurosci 32:591-601. 2009Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histones and other proteins and in regulating fundamental cellular activities such as transcription...
- The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian controlYasukazu Nakahata
Department of Pharmacology, University of California, Irvine, CA 92697, USA
Cell 134:329-40. 2008..The central clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for circadian function...
- SIRT1 regulates circadian clock gene expression through PER2 deacetylationGad Asher
Department of Molecular Biology, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
Cell 134:317-28. 2008..Given the NAD(+) dependence of SIRT1 deacetylase activity, it is likely that SIRT1 connects cellular metabolism to the circadian core clockwork circuitry...
- Biomarkers for predicting clinical responses to HDAC inhibitorsLindsay Stimson
Dept of Clinical Pharmacology, Laboratory of Cancer Biology, Oxford, United Kingdom
Cancer Lett 280:177-83. 2009Post-translational modifications of histone and non-histone proteins by acetylation are known to play a key role in tumourigenesis...
- HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancerJunkui Ai
Department of Urology, University of Pittsburgh School of Medicine, Pennsylvania 15232, USA
Mol Endocrinol 23:1963-72. 2009..deacetylase 6 (HDAC6) is implicated, but has not been proven, in regulating AR activity via modulating Hsp90 acetylation. Here, we report that knockdown of HDAC6 in C4-2 cells using short hairpin RNA impaired ligand-independent ..
- Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesisYu yi Lin
High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 136:1073-84. 2009..Among these, acetylation sites (Lys19 and 514) of phosphoenolpyruvate carboxykinase (Pck1p) were determined by tandem mass spectrometry...
- Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1Anne Rufiange
Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec CHUQ, Quebec, Canada
Mol Cell 27:393-405. 2007..This could facilitate induction of repressed genes. Importantly, we show that histone H3 K56 acetylation, a replication-associated mark, is also present in replication-independent newly assembled nucleosomes and ..
- Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assemblyQing Li
Department of Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Cell 134:244-55. 2008..However, the molecular functions of the acetylation of newly synthesized histones in this DNA replication-coupled nucleosome assembly pathway remain enigmatic...
- Histone Deacetylases and reversible acetylation in signaling and diseaseJOHN DENU; Fiscal Year: 2009..Over the last several years, emerging evidence suggests that acetylation of protein lysine residues may rival reversible phosphorylation as a major regulatory mechanism of cellular ..
- Histone Methylation: a role in excessive ethanol intake and self-administrationJennifer A Rinker; Fiscal Year: 2012..These posttranslational changes include: acetylation, phosphorylation, and methylation of histone amino acid residues...
- Role of Phospholipase C in Transcriptional RegulationAles Vancura; Fiscal Year: 2009..data indicate that plc1 cells display several phenotypes consistent with the role of Plc1p and InsPs in histone acetylation: (i) defect in recruitment of the SAGA complex to Sko1p-regulated promoters (Guha et al...
- Genistein and Prostate CancerRajvir Dahiya; Fiscal Year: 2010..inhibits prostate cancer growth through modulation of epigenetic events, such as DNA methylation and histone acetylation. To test this hypothesis, we will analyze: 1) Global methylation and enzymatic activity of DNA ..
- HTS development for targeted anti-fungal small moleculesPaul D Kaufman; Fiscal Year: 2010..In fungi, H3-K56 acetylation occurs on all newly synthesized molecules, but H3-K56ac is either not abundant or even detectable in mammalian ..
- Modulation of c-MYC Functions in an HTLV-1 Model for CarcinogenesisRobert Harrod; Fiscal Year: 2009..HTLV-1 p30II induces Lys- acetylation of c-MYC...
- Structure and Mechanism of Pathogen SET Domain HKMTsMing Ming Zhou; Fiscal Year: 2009Site-specific post-translational modifications of histones that include methylation, acetylation, phosphorylation and ubiquitination function individually and/or combinatorially as fundamental epigenetic mechanisms in histone-directed ..
- Role of the Fetus in the Initiation of ParturitionCAROLE MENDELSON; Fiscal Year: 2004..CREB-binding protein (CBP) and members of the steroid receptor coactivator (SRC) family, and in histone acetylation in myometrium of women in labor and in uterine tissues of pregnant mice at term...
- METABOLIC BASIS OF SULFONAMIDE TOXICITY IN AIDS PATIENTSCRAIG SVENSSON; Fiscal Year: 1999..The specific aims are to determine: 1. IF ARYLAMINE N-ACETYLATION ACTIVITY IS REDUCED IN HIV INFECTED PATIENTS...
- Hypoxia Signaling, Chromatin Remodeling and Nickel CarcinogenesisMax Costa; Fiscal Year: 2009..Hypoxia or agents that mimic hypoxia cause a global loss of histone acetylation and increase the methylation of H3 lysine 9 which is the chromatin mark of gene silencing for the individual ..
- WHY IS HISTONE ACETYLATION REDUCED AT MITOSIS?James Paulson; Fiscal Year: 1992..from the applicant's abstract): Histones, the major proteins of eukaryotic chromosomes, undergo reversible acetylation at certain lysine residues, but this acetylation is drastically reduced during normal mitosis and in metaphase-..
- Cell Growth Inhibiton and Estrogen ActionBarry Markaverich; Fiscal Year: 2004..Histone acetylation is temporally and functionally coupled to DNA replication and gene expression in experimental systems including ..
- ASPIRIN'S FIBRINOLYTIC EFFECT--ACETYLATION OF FIBRINOGENThorir Bjornsson; Fiscal Year: 1992..antithrombotic mechanism involves an irreversible inactivation of the platelet enzyme cyclooxygenase through o- acetylation of active site serine...
- 9-0 ACETYLATED SIALIC ACIDS ON T CELLSLaura Martin; Fiscal Year: 2002..9-O-acetylation can affect biologic properties of underlying molecules, altering host-pathogen recognition, modulating ..
- Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 PathwayMarc R Montminy; Fiscal Year: 2010..Preliminary studies indicate that TORC2 is transiently activated through P300-dependent acetylation during early fasting, when it stimulates the gluconeogenic program via an association with a histone methyl-..
- Resistance of Bacillus anthracis to lysozymeJonathan Dworkin; Fiscal Year: 2009..In Staphylococcus aureus, O-acetylation of the cell wall peptidoglycan has been identified as the modification that is responsible for lysozyme ..