Genomes and Genes
Summary: The ability of a substrate to allow the passage of ELECTRONS.
Publications393 found, 100 shown here
- Structural basis for modulation and agonist specificity of HCN pacemaker channelsWilliam N Zagotta
Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
Nature 425:200-5. 2003..On the basis of amino acid sequence similarity to HCN channels, the cyclic nucleotide-gated, and eag- and KAT1-related families of channels are probably related to HCN channels in structure and mechanism...
- Reconstruction of conductivity and current density images using only one component of magnetic field measurementsJin Keun Seo
Department of Mathematics, Yonsei University, Seoul 120 749, Korea
IEEE Trans Biomed Eng 50:1121-4. 2003..In our new MRCDI technique, we need to measure only one component of the induced magnetic flux density and reconstruct both cross-sectional conductivity and current density images without any subject rotation...
- Principles of conduction and hydrophobic gating in K+ channelsMorten Ø Jensen
DE Shaw Research, New York, NY 10036, USA
Proc Natl Acad Sci U S A 107:5833-8. 2010....
- TRP-PLIK, a bifunctional protein with kinase and ion channel activitiesL W Runnels
Howard Hughes Medical Institute, Department of Cardiology, Department of Neurobiology, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Children s Hospital, Boston, MA 02115, USA
Science 291:1043-7. 2001..Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function...
- mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channelsA Butler
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
Science 261:221-4. 1993..A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene...
- Balanced inhibition underlies tuning and sharpens spike timing in auditory cortexMichael Wehr
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nature 426:442-6. 2003..Balanced inhibition might thus serve to increase the temporal precision and thereby reduce the randomness of cortical operation, rather than to increase noise as has been proposed previously...
- Prestin is the motor protein of cochlear outer hair cellsJ Zheng
The Hugh Knowles Center, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
Nature 405:149-55. 2000..We also demonstrate this nonlinear capacitance in transfected kidney cells. We conclude that prestin is the motor protein of the cochlear outer hair cell...
- Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brainB Santoro
Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Cell 93:717-29. 1998....
- Nanowired three-dimensional cardiac patchesTal Dvir
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Nanotechnol 6:720-5. 2011..It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches...
- Quantitative conductivity and permittivity imaging of the human brain using electric properties tomographyTobias Voigt
Department of Electrical Engineering and Information Technology, Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany
Magn Reson Med 66:456-66. 2011..g., in tumor diagnosis. In the framework of radiofrequency safety, the electric conductivity of tissue is needed to correctly estimate the local specific absorption rate distribution during MR ..
- Synthesis of oxidation-resistant cupronickel nanowires for transparent conducting nanowire networksAaron R Rathmell
Department of Chemistry, Duke University, 124 Science Drive, Box 90354 Durham, North Carolina 27708, United States
Nano Lett 12:3193-9. 2012..These properties, and the fact that copper and nickel are 1000 times more abundant than indium or silver, make cupronickel nanowires a promising alternative for the sustainable, efficient production of transparent conductors...
- Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineeringLaleh Ghasemi-Mobarakeh
Islamic Azad University, Najafabad Branch, Isfahan, Iran
J Tissue Eng Regen Med 5:e17-35. 2011..Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed...
- The effect of brain hematoma location on volumetric inductive phase shift spectroscopy of the brain with circular and magnetron sensor coils: a numerical simulation studyR Rojas
Universidad del Ejército y FAM EMGS Laboratorio Multidisciplinario de Investigación, DF, Mexico
Physiol Meas 29:S255-66. 2008..Furthermore it was found that the relative sensitivity of circular and magnetron sensor coils with respect to the occurrence of hematoma varies with the location of the hematoma...
- Can high-field MREIT be used to directly detect neural activity? Theoretical considerationsR J Sadleir
J Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
Neuroimage 52:205-16. 2010..We also propose the idea of using MREIT as an alternative means of studying neuromodulation...
- Biophysical and molecular mechanisms of Shaker potassium channel inactivationT Hoshi
Department of Molecular and Cellular Physiology, Stanford University, School of Medicine, CA 94305
Science 250:533-8. 1990..A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation...
- Cardiac anisotropy in boundary-element models for the electrocardiogramMark Potse
Research Center, Sacre Coeur Hospital, 5400 Boulevard Gouin Ouest, Montreal, QC, H4J 1C5, Canada
Med Biol Eng Comput 47:719-29. 2009..Its major disadvantage is its perceived inability to deal with the anisotropic electric conductivity of the myocardial interstitium, which led researchers to represent only intracellular anisotropy or ..
- Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokersA Rembert Koczulla
Department of Internal Medicine, Division of Pulmonary Diseases, University Hospital Giessen and Marburg, Marburg, Germany koczulla med uni marburg de
Respiration 79:61-7. 2010..Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of inflammation...
- Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channelRandal B Bass
Division of Chemistry and Chemical Engineering, Biochemistry Option, Howard Hughes Medical Institute, Mail Code 114 96, California Institute of Technology, Pasadena, CA 91125, USA
Science 298:1582-7. 2002..Although MscS is likely to be structurally distinct from other ion channels, similarities in gating mechanisms suggest common structural elements...
- Current constrained voltage scaled reconstruction (CCVSR) algorithm for MR-EIT and its performance with different probing current patternsOzlem Birgul
Department of Electrical and Electronics Engineering, Middle East Technical University, 06531 Ankara, Turkey
Phys Med Biol 48:653-71. 2003..The spatial resolution is limited by the larger element size of the finite element mesh and twice the magnetic resonance image pixel size...
- The conductivity of the human skull: results of in vivo and in vitro measurementsT F Oostendorp
Department of Medical Physics and Biophysics, University of Nijmegen, The Netherlands
IEEE Trans Biomed Eng 47:1487-92. 2000..An explanation is provided for this discrepancy, indicating that the correct ratio is 1:1/15:1...
- Conductivity and current density image reconstruction using harmonic Bz algorithm in magnetic resonance electrical impedance tomographySuk Hoon Oh
Graduate School of East West Medical Sciences, Kyung Hee University, Korea
Phys Med Biol 48:3101-16. 2003..The results suggest that in vitro and in vivo experimental studies with animal subjects are feasible. Further studies are requested to reduce the amount of injection current down to less than 1 mA for human subjects...
- Measurement of ion diffusion using magnetic resonance electrical impedance tomographyMark J Hamamura
Tu and Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
Phys Med Biol 51:2753-62. 2006..The results indicate that MREIT was able to monitor the changing conductivity and concentration distributions resulting from the diffusion of ions within the agarose gel phantom...
- Contactless conductivity detection for microfluidics: designs and applicationsMartin Pumera
ICYS, National Institute for Materials Science, 1 1 Namiki, Tsukuba 305 0044, Japan
Talanta 74:358-64. 2007..Various applications for security, pharmacological, bioassays and food analysis purposes are described...
- Dipole location errors in electroencephalogram source analysis due to volume conductor model errorsB Vanrumste
Department of Electronics and Information Systems, Ghent University, Belgium
Med Biol Eng Comput 38:528-34. 2000..It was found that the location errors due to underestimating skull conductivity are typically higher than those found due to neglecting the VS or neglecting a hole in the skull...
- Dielectrophoretic manipulation of cells with spiral electrodesX B Wang
Department of Experimental Pathology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Biophys J 72:1887-99. 1997..Applications of spiral electrode arrays, including the isolation of cells of clinical relevance, are discussed...
- Electrolyte-gated graphene field-effect transistors for detecting pH and protein adsorptionYasuhide Ohno
The Institute of the Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Nano Lett 9:3318-22. 2009..The GFETs thus acted as highly sensitive electrical sensors for detecting pH and biomolecule concentrations...
- Salt dependence of ion transport and DNA translocation through solid-state nanoporesRalph M M Smeets
Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
Nano Lett 6:89-95. 2006..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM...
- The need for correct realistic geometry in the inverse EEG problemG Huiskamp
Department of Clinical Neurophysiology, University Hospital Utrecht, The Netherlands
IEEE Trans Biomed Eng 46:1281-7. 1999..These errors are comparable to those found when overestimating or underestimating skull conductivity by a factor of two...
- Novel dry polymer foam electrodes for long-term EEG measurementChin Teng Lin
Department of Electrical Engineering, Institute of Imaging and Biomedical Photonics and Brain Research Center, National Chiao Tung University, Hsinchu 300, Taiwan
IEEE Trans Biomed Eng 58:1200-7. 2011..The experimental results presented that the dry foam electrode performs better for long-term EEG measurement, and is practicable for daily life applications...
- Electrical conductivity imaging using gradient B, decomposition algorithm in magnetic resonance electrical impedance tomography (MREIT)Chunjae Park
College of Electronics and Information, Kyung Hee University, Kyungki 449 701, Korea
IEEE Trans Med Imaging 23:388-94. 2004..Numerical simulations with added random noise of realistic amounts show the feasibility of the algorithm in practical applications and also its robustness against measurement noise...
- Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell lineKeiko Ishihara
Department of Physiology, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
J Physiol 556:61-78. 2004..Polyamines may regulate the amplitude of the outward I(K1), not only by blocking the channels but also by modifying the proportion of channels that show different sensitivities to the polyamine block...
- How spike generation mechanisms determine the neuronal response to fluctuating inputsNicolas Fourcaud-Trocmé
Centre National de la Recherche Scientifique Unité Mixte de Recherche 8119, Neurophysique et Physiologie du Système Moteur, Unité de Formation et de Recherche Biomédicale, Universite Paris 5 Rene Descartes, 75270 Paris Cedex 06, France
J Neurosci 23:11628-40. 2003..Our study shows how an intrinsic neuronal property (the characteristics of fast sodium channels) determines the speed with which neurons can track changes in input...
- A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channelsL Heginbotham
Department of Neurobiology, Harvard Medical School, Boston, MA 02115
Science 258:1152-5. 1992....
- Solution-processed metal nanowire mesh transparent electrodesJung Yong Lee
Department of Electrical Engineering, Stanford University, Stanford, California 94305, USA
Nano Lett 8:689-92. 2008..Organic solar cells deposited on these electrodes show a performance equivalent to that of devices based on a conventional metal-oxide transparent electrode...
- The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathwaysA N Akopian
Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
Nat Neurosci 2:541-8. 1999..These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects...
- TRPC channel activation by extracellular thioredoxinShang Zhong Xu
Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
Nature 451:69-72. 2008..The data indicate the presence of a previously unrecognized ion-channel activation mechanism that couples extracellular thioredoxin to cell function...
- A large-conductance mechanosensitive channel in E. coli encoded by mscL aloneS I Sukharev
Laboratory of Molecular Biology, University of Wisconsin Madison 53706
Nature 368:265-8. 1994..The mscL nucleotide sequence predicts a unique protein of only 136 amino acids, with a highly hydrophobic core and very different from porins or other known proteins...
- Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressantH Wulff
Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 97:8151-6. 2000..Combinations of TRAM-34 and cyclosporin A are more effective in suppressing lymphocyte mitogenesis than either compound alone. Our studies suggest that TRAM-34 and related compounds may hold therapeutic promise as immunosuppressants...
- In vivo electrical conductivity of hepatic tumoursDieter Haemmerich
Department of Surgery, University of Wisconsin Madison, 600 Highland Avenue, WI 53792, USA
Physiol Meas 24:251-60. 2003..05). We conclude that necrosis within the tumour and the associated membrane breakdown is likely responsible for the observed change in conductivity...
- Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShBW N Zagotta
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305
Science 250:568-71. 1990..These results support the proposal that inactivation occurs by a cytoplasmic domain that occludes the ion-conducting pore of the channel...
- From antiferromagnetic insulator to correlated metal in pressurized and doped LaMnPOJ W Simonson
Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, USA
Proc Natl Acad Sci U S A 109:E1815-9. 2012..Proximity to these charge and moment delocalization transitions in LaMnPO results in a highly correlated metallic state, the familiar breeding ground of superconductivity...
- Capacitively coupled contactless conductivity detection for microseparation techniques - recent developmentsPavel Kuban
Institute of Analytical Chemistry of the Academy of Sciences of the Czech Republic, Brno, Czech Republic
Electrophoresis 32:30-42. 2011....
- Determination of soil pore water salinity using an FDR sensor working at various frequencies up to 500 MHzAndrzej Wilczek
Institute of Agrophysics, Polish Academy of Sciences, ul Doświadczalna 4, 20 290 Lublin, Poland
Sensors (Basel) 12:10890-905. 2012..As a result, the salinity index method applied for FDR measurements may be adapted to field use after examination of loam and clayey soils...
- Current saturation and voltage gain in bilayer graphene field effect transistorsB N Szafranek
Advanced Microelectronic Center Aachen AMICA, AMO GmbH, Otto Blumenthal Strasse 25, 52074 Aachen, Germany
Nano Lett 12:1324-8. 2012..Using numerical simulations based on an atomistic p(z) tight-binding Hamiltonian we demonstrate that this approach can be extended to sub-100 nm gate lengths...
- Magnetic induction tomography: hardware for multi-frequency measurements in biological tissuesH Scharfetter
Institute for Biomedical Engineering, Technical University of Graz, Austria
Physiol Meas 22:131-46. 2001..On-line spectroscopy of tissue conductivity with low spatial resolution appears feasible, thus enabling applications such as non-invasive monitoring of brain oedema...
- Flexible solid-state supercapacitors based on three-dimensional graphene hydrogel filmsYuxi Xu
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States
ACS Nano 7:4042-9. 2013..6 μA), excellent cycling stability, and extraordinary mechanical flexibility. This study demonstrates the exciting potential of 3D graphene macrostructures for high-performance flexible energy storage devices...
- Conducting polymers in electronic chemical sensorsJiri Janata
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
Nat Mater 2:19-24. 2003..Our aim here is to discuss the usability of conducting polymers in both types of electronic applications in light of these two parameters...
- Metal-intercalated aromatic hydrocarbons: a new class of carbon-based superconductorsYoshihiro Kubozono
Research Laboratory for Surface Science, Okayama University, Okayama, Japan
Phys Chem Chem Phys 13:16476-93. 2011..The features of other carbon-based superconductors are compared to clarify the nature of hydrocarbon superconductors...
- Scanning tunneling microscopy characterization of the electrical properties of wrinkles in exfoliated graphene monolayersKe Xu
Division of Chemistry and Chemical Engineering, Kavli Nanoscience Institute, California Institute of Technology, MC 127 72, Pasadena, California 91125, USA
Nano Lett 9:4446-51. 2009..The observed wrinkles are likely important for understanding the electrical properties of graphene...
- Solution-processed metallic conducting polymer films as transparent electrode of optoelectronic devicesYijie Xia
Department of Materials and Engineering, National University of Singapore, Singapore
Adv Mater 24:2436-40. 2012..These PEDOT:PSS films with conductivity and transparency comparable to ITO can replace ITO as the transparent electrode of optoelectronic devices...
- A comparison of conductive textile-based and silver/silver chloride gel electrodes in exercise electrocardiogram recordingsVaidotas Marozas
Kaunas University of Technology, Biomedical Engineering Institute, Kaunas, Lithuania
J Electrocardiol 44:189-94. 2011..The goal of this study was to compare disposable silver/silver chloride and reusable conductive textile-based electrodes in electrocardiogram (ECG) signal monitoring during physical activity...
- Use of conductive gels for electric field homogenization increases the antitumor efficacy of electroporation therapiesAntoni Ivorra
Department of Bioengineering, Department of Mechanical Engineering and Graduate Programin Biophysics, University of California at Berkeley, Berkeley, CA 94720, USA
Phys Med Biol 53:6605-18. 2008..We found that conductivity mismatching errors are surprisingly well tolerated by the technique. Gels with conductivities ranging from 5 mS cm(-1) to 10 mS cm(-1) will be a proper solution for most cases...
- Determination of electric conductivity and local SAR via B1 mappingUlrich Katscher
Medical Imaging Systems Division, Philips Research Europe, Hamburg, Germany
IEEE Trans Med Imaging 28:1365-74. 2009The electric conductivity can potentially be used as an additional diagnostic parameter, e.g., in tumor diagnosis...
- In vivo muscle electroporation threshold determination: realistic numerical models and in vivo experimentsSelma Corovic
University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia
J Membr Biol 245:509-20. 2012..Our model of muscle with skin also confirms the in vivo findings of previous studies that electroporation "breaks" the skin barrier when the applied voltage is above 50 V...
- Identifying single nucleotides by tunnelling currentMakusu Tsutsui
The Institute of Scientific and Industrial Research, Osaka University, 8 1 Mihogaoka, Ibaraki, Osaka 567 0047, Japan
Nat Nanotechnol 5:286-90. 2010..We also demonstrate statistical identification of the nucleotides based on their electrical conductivity, thereby providing an experimental basis for a DNA sequencing technology based on measurements of electron transport...
- Novel anisotropic engineered cardiac tissues: studies of electrical propagationNenad Bursac
Biomedical Engineering Department, Duke University, 3000 Science Drive, Durham, NC 27708, USA
Biochem Biophys Res Commun 361:847-53. 2007..In summary, this study is the first successful attempt to engineer a cm(2)-size, functional anisotropic cardiac tissue patch...
- The stimulation of myoblast differentiation by electrically conductive sub-micron fibersIndong Jun
Department of Bioengineering, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
Biomaterials 30:2038-47. 2009....
- NMDA receptor contributions to visual contrast codingMichael B Manookin
Neuroscience Program, University of Michigan, Ann Arbor, MI 48105, USA
Neuron 67:280-93. 2010..NMDA receptors contribute to visual contrast coding in a cell-type-specific manner. Certain cell types generate excitatory responses using primarily AMPA receptors or disinhibition...
- Tuning transport properties of nanofluidic devices with local charge inversionYan He
Department of Physics and Astronomy, University of California, Irvine, Irvine, California, USA
J Am Chem Soc 131:5194-202. 2009..These effects are reversible so that the transport and selectivity characteristics of ionic devices can be tuned, much as the gate voltage tunes the properties of a semiconductor...
- Measuring the dielectric properties of herpes simplex virus type 1 virions with dielectrophoresisMichael P Hughes
Department of Electronics and Electrical Engineering, Bioelectronic Research Centre, University of Glasgow, Scotland, Glasgow, UK
Biochim Biophys Acta 1571:1-8. 2002..It is shown that the observed changes in the dielectrophoretic spectrum, and the variations in the dielectric properties of the virus concur with the expected physiological effects of these agents...
- Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cellsAmy K Weaver
Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Neurosci Res 78:224-34. 2004....
- Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43S Elenes
Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana 46202, USA
Biophys J 81:1406-18. 2001..Our results also suggest that heterotypic docking may lead to conformational changes that inhibit this action of the Cx43 carboxyl-terminal domain...
- Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neuronsY H Zhang
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
J Physiol 544:385-402. 2002..This NGF-induced sensitization is probably mediated by activation of the sphingomyelin signalling pathway to liberate ceramide(s), wherein ceramide appears to be the second messenger involved in modulating neuronal excitability...
- Gap junctions remain open during cytochrome c-induced cell death: relationship of conductance to 'bystander' cell killingK Cusato
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cell Death Differ 13:1707-14. 2006....
- Influence of anisotropic conductivity on EEG source reconstruction: investigations in a rabbit modelDaniel Güllmar
Biomagnetic Center, Department of Neurology, Jena, Germany
IEEE Trans Biomed Eng 53:1841-50. 2006..In contrast, dipole orientation and dipole strength are influenced significantly by the anisotropy. We conclude that the inclusion of tissue anisotropy information improves source estimation procedures...
- Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligandsPablo Artigas
Laboratory of Cardiac Membrane Physiology, Rockefeller University, New York, NY 10021 6399, USA
J Gen Physiol 123:357-76. 2004..5 A wide. Enhanced understanding of palytoxin action now allows its use for examining the structures and mechanisms of the gates that occlude/deocclude transported ions during the normal Na/K pump cycle...
- PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currentsHailin Zhang
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
Neuron 37:963-75. 2003..Finally, native or recombinant channels inhibited by muscarinic agonists can be activated by PIP(2). Our data strongly suggest that PIP(2) acts as a membrane-diffusible second messenger to regulate directly the activity of KCNQ currents...
- Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coliC C Cruickshank
Department of Pharmacology, University of Western Australia, Nedlands
Biophys J 73:1925-31. 1997..This channel diameter is consistent with the proposed homohexameric model of the MscL...
- A chemical route to graphene for device applicationsScott Gilje
Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
Nano Lett 7:3394-8. 2007..Temperature-dependent conductivity indicates that the graphene-like sheets exhibit semiconducting behavior...
- Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysisChristoph Bachmeyer
CNR ITC Istituto di Biofisica Sezione di Trento, Via Sommarive 18, I 38050, Povo, Italy
J Mol Biol 333:527-40. 2003..The off-rate varied between about 10 s(-1) and 3900 s(-1) and depended on the structure of the ligand. The role of structural requirements for the effective block of C2II by the different ligands is discussed...
- A flexible strain sensor based on a Conductive Polymer Composite for in situ measurement of parachute canopy deformationCédric Cochrane
University Lille Nord de France, F 59000 Lille, France
Sensors (Basel) 10:8291-303. 2010..Finally, our sensor was tested on a parachute canopy during a real drop test: the canopy fabric deformation during the critical inflation phase was successfully measured, and was found to be less than 9%...
- Fundamental aspects of contactless conductivity detection for capillary electrophoresis. Part I: Frequency behavior and cell geometryPavel Kuban
Department of Chemistry, University of Basel, Basel, Switzerland
Electrophoresis 25:3387-97. 2004..The frequency setting has to be optimized for each cell design, operational amplifier, electrolyte solution and capillary...
- The aromatic binding site for tetraethylammonium ion on potassium channelsL Heginbotham
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
Neuron 8:483-91. 1992..These findings are consistent with a TEA-binding site formed by a bracelet of pore-lining aromatic residues. The center of the bracelet could bind a TEA molecule through a cation-pi orbital interaction...
- Electric currents couple spatially separated biogeochemical processes in marine sedimentLars Peter Nielsen
Department of Biological Sciences, Aarhus University, Ny Munkegade 114, DK 8000 Aarhus C, Denmark
Nature 463:1071-4. 2010..Electrical communication between distant chemical and biological processes in nature adds a new dimension to our understanding of biogeochemistry and microbial ecology...
- Functionalized single graphene sheets derived from splitting graphite oxideHannes C Schniepp
J Phys Chem B 110:8535-9. 2006..Although graphite oxide is an insulator, functionalized graphene produced by this method is electrically conducting...
- Accordion-like honeycombs for tissue engineering of cardiac anisotropyGeorge C Engelmayr
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25 330 Cambridge, Massachusetts 02139, USA
Nat Mater 7:1003-10. 2008....
- Pacemaker channels produce an instantaneous currentCatherine Proenza
Ion Channel Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
J Biol Chem 277:5101-9. 2002....
- Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexiaD Langosch
Max Planck Institut für Hirnforschung, Frankfurt, Germany
EMBO J 13:4223-8. 1994..In addition, our data reveal that structural modifications of the ion-channel region can affect agonist binding to the glycine receptor...
- Computer model of action potential of mouse ventricular myocytesVladimir E Bondarenko
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214 3078, USA
Am J Physiol Heart Circ Physiol 287:H1378-403. 2004..The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice...
- Artificial synaptic conductances reduce subthreshold oscillations and periodic firing in stellate cells of the entorhinal cortexFernando R Fernandez
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02115, USA
J Neurosci 28:3790-803. 2008..Our results suggest that subthreshold oscillations may contribute less to in vivo response properties than has been hypothesized...
- IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channelsY I Kim
Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908
Science 239:405-8. 1988..Therefore, Lambert-Eaton syndrome IgG reacts with voltage-dependent calcium channels and blocks their function, a phenomenon that can account for the presynaptic impairment characteristic of this disorder...
- Magnetoacoustic tomography with magnetic induction (MAT-MI)Yuan Xu
Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
Phys Med Biol 50:5175-87. 2005..The promising pilot experimental results suggest the feasibility of the proposed MAT-MI approach...
- Characterization of nucleic acids by nanopore analysisDavid W Deamer
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Acc Chem Res 35:817-25. 2002..As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade...
- Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3Elizabeth A Cowley
Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
J Physiol 538:747-57. 2002....
- Gating of the large mechanosensitive channel in situ: estimation of the spatial scale of the transition from channel population responsesChien Sung Chiang
Department of Biology, University of Maryland College Park, Maryland 20742, USA
Biophys J 86:2846-61. 2004..4 +/- 4.8 nm(2), the latter being consistent with structural models of MscL, which predict deltaA = 23 nm(2)...
- Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteinsR Huber
Max Planck Institut fur Biochemie, Martinsried, Germany
J Mol Biol 223:683-704. 1992..We suggest that annexins bind with their convex face to membranes, causing local disorder and permeability of the phospholipid bilayers. Annexins are Janus-faced proteins that face phospholipid and water and mediate calcium transport...
- Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cellsFabien Vanden Abeele
Laboratoire de Physiologie Cellulaire, INSERM EPI 9938, Universite des Sciences et Technologies de Lille, Batiment SN3, 59655 Villeneuve d Ascq cedex, France
Cancer Cell 1:169-79. 2002..Our data therefore suggest the pivotal role of SOCs in apoptosis and cancer progression...
- The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)A Surprenant
Glaxo Institute for Molecular Biology, Geneva, Switzerland
Science 272:735-8. 1996..Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells...
- A global sensitivity analysis of three- and four-layer EEG conductivity modelsSylvain Vallaghé
Odysśee Team Project, Institut National de Recherche en Informatique et en Automatique, Sophia Antipolis 06902, France
IEEE Trans Biomed Eng 56:988-95. 2009..This global sensitivity analysis gives new information about EEG forward models--it identifies the main input parameters that need model refinement--and directions on how to calibrate these models...
- Single molecule measurements of DNA transport through a nanoporeAmit Meller
The Rowland Institute for Science at Harvard, 100 Edwin H Land Boulkevard, Cambridge, MA 02142, USA
Electrophoresis 23:2583-91. 2002..The single molecule approach we used revealed molecular interactions that can influence both capture rates and translocation velocities in a manner that enriches naive barrier crossing models...
- Daily electrical silencing in the mammalian circadian clockMino D C Belle
Faculty of Life Sciences, A V Hill Building, University of Manchester, Manchester M13 9PT, UK
Science 326:281-4. 2009....
- Estimating brain conductivities and dipole source signals with EEG arraysDavid Gutierrez
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 7053, USA
IEEE Trans Biomed Eng 51:2113-22. 2004..We also present numerical examples evaluating the sensitivity to imprecise assumptions on the source position and skull thickness. Finally, we propose extensions to the case of unknown source position and present examples for real data...
- The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptorsJeremy E Niven
Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, UK
Nature 421:630-4. 2003....
- The effect of polypyrrole on arteriogenesis in an acute rat infarct modelShirley S Mihardja
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Biomaterials 29:4205-10. 2008..The results of this study highlight the potential clinical benefit of using this alginate-polypyrrole polymer blend as an injectable scaffold to repair ischemic myocardium after myocardial infarction...
- Taurine suppresses the spread of cell death in electrically coupled RPE cellsChandani Udawatte
Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA
Mol Vis 14:1940-50. 2008....
- Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cellsHalima Ouadid-Ahidouch
Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
Biochem Biophys Res Commun 316:244-51. 2004..However, these K+ channels did not regulate the cell proliferation because of their minor role in the membrane potential...
- Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic diseaseMaria E Mycielska
Department of Biological Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ, UK
J Cell Sci 117:1631-9. 2004..This could have important implications for the metastatic process and has clinical implications. Galvanotaxis could thus play a significant role in both cellular physiology and pathophysiology...
- Slow gating charge immobilization in the human potassium channel Kv1.5 and its prevention by 4-aminopyridineD Fedida
Department of Physiology, Queen s University, Kingston, Ontario, Canada
J Physiol 494:377-87. 1996..Some actions of 4-AP appear independent of its properties as a blocker of open K+ channels, and are not mimicked by internal TEA...
- The size of gating charge in wild-type and mutant Shaker potassium channelsN E Schoppa
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510
Science 255:1712-5. 1992..These results can be explained by a model for channel activation in which the equilibria of voltage-dependent steps are altered in the mutant channels...
- Effects of membrane potential on the voltage dependence of motility-related charge in outer hair cells of the guinea-pigJ Santos-Sacchi
Sections of Otolaryngology and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
J Physiol 510:225-35. 1998..Through modelling, we indicate how the effect may be explained by an intrinsic voltage-induced tension generated by the molecular motors residing in the lateral membrane...
- Highly efficient restoration of graphitic structure in graphene oxide using alcohol vaporsChing Yuan Su
Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan
ACS Nano 4:5285-92. 2010..In the high mobility regime, the growth of the graphitic domain size becomes dominant for enhancing its electrical conductivity. The excellent electrical conductivity of the reduced GO sheets promises potential electronic applications...
- Mechanism of G protein Activation by Ric-8AStephen R Sprang; Fiscal Year: 2013....
- Biosensing in electrochemically controlled nano-junctionsKrzysztof Slowinski; Fiscal Year: 2013..g. TATA binding protein) at the single molecule level. Demonstrating the feasibility of such detection is critically important in the development of DNA based nano-sensors. ..
- Multi-excitation magnetoacoustic imaging of tissue conductivitiesBin He; Fiscal Year: 2013..The successful development of a high-resolution, non-ionizing, cost-effective electrical impedance imaging system will have a significant impact to screening and early detection of breast cancer. ..
- Biophysical Modeling of Fluid and Solute Transport in the TMJ DiscHai Yao; Fiscal Year: 2010..In future studies we will use the pig to test these models further, compare different regenerative regimens, as well as design and evaluate human replacement TMJ tissues. ..
- LLISA: ???Liposome-Linked Immunosorbant Assay??? for Detection of HIV Viral LoadAbraham P Lee; Fiscal Year: 2013..With the integration of these two sets of expertise, we expect to address the grand challenge of developing point-of-care viral load assays. ..
- VAPOR GROWN CARBON FIBERS FOR BIOMEDICAL APPLICATIONSTHOMAS APPLE; Fiscal Year: 1993..We will, thus, determine the optimal preparation and processing conditions which will lead to advanced materials for prothesis, neural and biochemical use...
- Modeling the neuronal activations induced by transcranial magnetic stimulationFELIPE SANTIAGO SALINAS; Fiscal Year: 2011..By the modeling the electric fields produced by TMS we can better understand the mechanisms of neuronal activation, including how a particular disease/disorder may be affecting the nervous system. ..
- Biophysics of Acupuncture: Electrical Properties of Loose Connective TissueAndrew Ahn; Fiscal Year: 2009..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on the biophysics of acupuncture. ..
- Conductivity-weighted ultrasound for cancer detectionK Kirk Shung; Fiscal Year: 2010..EMAI produces conductivity-weighted ultrasound which will potentially improve diagnostic performance in cancer screening, and may be especially useful for screening and diagnosing breast cancer. ..
- ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATIONJohn Webster; Fiscal Year: 2002..In vitro tests on myocardium will yield physical parameters of electric conductivity, and thermal conduction, capacity, and heat convection variation throughout the endocardium...
- Breast Cancer Diagnosis by Electrical Impedance ImagingJONATHAN NEWELL; Fiscal Year: 2009..Success of such a trial would reduce the need for biopsy and increase the detection of tumors at an earlier stage, which would reduce the morbidity and mortality of breast cancer. ..
- ADAPTIVE ELECTRIC CURRENT COMPUTED TOMOGRAPHY SYSTEMJONATHAN NEWELL; Fiscal Year: 1990..Full advantage of this flexibility is achieved by the use of the adaptive current algorithm which selects the optimal current pattern to apply based upon the observed unknown conductivities...
- MRI-Guided, Robotically Controlled Cardiac AblationJohn Pauly; Fiscal Year: 2009..This research also initially targets atrial fibrillation as it is very common (1 in 4 Americans develop it in their lifetime), leads to 1/3 of strokes, and there is a need for a successful method to cure it less invasively. ..
- TOXICITY OF CHLOROPHENOLS IN MITOCHONDRIAL MEMBRANESPavel Smejtek; Fiscal Year: 1990....
- 3-D Microwave Imaging System for Breast Cancer DetectionQing Liu; Fiscal Year: 2006....
- Nanowire DNA hybridization sensorR Daniels; Fiscal Year: 2004..abstract_text> ..
- PREVENTION OF MITOCHONDRIAL AGING BY OMEGA-3 FATTY ACIDSWilliam Stillwell; Fiscal Year: 1991..Mitochondrial properties to be followed as a function of age will include lipid analysis, respiratory control index and P/O ratios, membrane fluidity, lipid peroxidation, permeability to protons and electrical conductivity...
- Combined Ultrasound and Electrical Impedance TomographyJONATHAN NEWELL; Fiscal Year: 2006..This would reduce morbidity and mortality. [unreadable] [unreadable] [unreadable]..
- Conductive Bioceramic Coatings for Neural ProsthesesFRANCIS KEOHAN; Fiscal Year: 2004..Phase II objectives would include optimization of coatings for processability, electrical properties, and physiological compatibility, and chronic implantation testing. ..
- Thermoacoustic and Inverse Scattering Breast Cancer ScannerSteven Johnson; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- The Osteoblastic Monolayer as a 'Gatekeeper' in BoneMELISSA KNOTHE TATE; Fiscal Year: 2003..This study is expected to provide insight into new strategies for treatment of bone diseases such as osteoporosis and osteoarthritis. ..
- BRAIN IMPEDANCE MEASUREMENT FOR NEUROLOGICAL EVALUATIONK JEFFREY ERIKSEN; Fiscal Year: 1999..abstract_text> ..
- Biomechanical Characterization of Human Cartilaginous End-PlateHai Yao; Fiscal Year: 2010....
- EARLY CARIES DETECTION AND INTERVENTIONJames Wefel; Fiscal Year: 2005..The collaborative efforts of the three research-intensive Universities, the long- standing expertise and diverse populations offer a unique combination of resources for this P01. ..
- ELECTROMECHANICAL PROPERTIES OF INTERVERTEBRAL DISCWeiyong Gu; Fiscal Year: 2002..The results will be useful for the future development of theoretical modeling as well as minimally invasive diagnostic tools for disc degeneration. ..
- Elastomeric Multi-Poled Neuroprosthetic Devices for Chronic ImplantationFRANCIS KEOHAN; Fiscal Year: 2006..The broader impact to society of this new technology would be more effective treatments for neurological disorders including Parkinson's disease, epilepsy, deafness, stroke, and paralysis. [unreadable] [unreadable] [unreadable]..
- Simulation of Therapeutic ERCPKevin Kunkler; Fiscal Year: 2003..Clinical experts will provide formative evaluations, and a construct validity study will test whether the simulator can discriminate among experts, intermediates, and novices. ..
- LIPID-MEDIATED MEMBRANE PROTEIN INSERTION AND FOLDINGGordon Tollin; Fiscal Year: 2004..These studies have broad implications for membrane-based processes important in many disease states. ..
- Detection of neonatal ventricular hemorrhage using EITRosalind Sadleir; Fiscal Year: 2006..These data will be analyzed to determine the best way of separating artifacts produced by shape changes and other body impedance changes from the bleeding process. ..
- Biophysical Modeling of Solute Transport in Human IVDWeiyong Gu; Fiscal Year: 2008..A plan for sharing and disseminating the theory, techniques, and data developed in this research is also included. [unreadable] [unreadable]..
- Novel Quantitative Technology for Tissue EngineeringChun Yuh Charles Huang; Fiscal Year: 2010..In this project, a new bioreactor system will be designed and fabricated. New methods and techniques for characterizing of mechano-electrochemical properties of the engineered tissue will be developed. ..
- Microwave Thermal Monitoring for Breast HyperthermiaPAUL MEANEY; Fiscal Year: 2003..It will set the stage for future treatment/monitoring systems targeting other anatomical sites. ..
- Molecular Mechanisms of Na Channel Slow InactivationARIE STRUYK; Fiscal Year: 2005..abstract_text> ..
- Microwave Thermal Monitoring for Breast HyperthermiaPAUL MEANEY; Fiscal Year: 2002..It will set the stage for future treatment/monitoring systems targeting other anatomical sites. ..
- Putting Molecular Dynamics to the Test: Ion PermeationOlaf Andersen; Fiscal Year: 2008..abstract_text> ..
- A Microfluidic Platform for Early Detection and Prognostication of CancerAaron Wheeler; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- RBC Ion Transporters as Hemoglobinopathy Risk ModifiersSeth Alper; Fiscal Year: 2009..The proposed experiments will increase understanding of sickle cell disease and thalassemia by providing mouse models for genetic tests of new drug therapies under development for near-term clinical testing. ..
- STRUCTURE AND FUNCTION OF POTASSIUM CHANNELSBrad S Rothberg; Fiscal Year: 2010..These experiments will enable the resolution of conformational steps in the Ca2+-dependent gating pathway that cannot be resolved using electrophysiological or X-ray experiments. ..
- Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne ToxicantsRadislav A Potyrailo; Fiscal Year: 2010..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
- BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBESJames F Rusling; Fiscal Year: 2010..In addition to achieving our specific aims, this project should provide fundamental guidance for fabrication of sensitive microarray devices for a wide variety of biomedical applications. ..
- STRUCTURE-FUNCTION OF CONNEXIN PORESAndrew Harris; Fiscal Year: 2009..In the present proposal, this analysis will be applied to Cx32 and Cx26, defects in which cause X-linked Charcot-Marie-Tooth disease neuropathy and sensorineural deafness, respectively. ..
- Novel Mechanism of Uranium Reduction Via Microbial NanowiresGemma Reguera; Fiscal Year: 2011....
- VOLTAGE-GATED PROTON CHANNELS IN HUMAN NEUTROPHILSTHOMAS DECOURSEY; Fiscal Year: 2008..5) We will identify the proton channel molecule and gene. ..
- Electrowetting Sample Prep for MALDI Mass SpectrometryAaron Wheeler; Fiscal Year: 2005..If successful, this will be a major advance over existing technologies, which do not have the capacity to combine high-throughput arrays with sample processing. ..
- Multi-slice Perfusion MR Imaging of the Human KidneyH Gach; Fiscal Year: 2004..abstract_text> ..
- Soy Isoflavones on NO Production in Postmenopausal WomenWilliam Wong; Fiscal Year: 2003..3 % pool/h in NO production, 0.2 mmol/d in urinary nitrate excretion, 1 mmHg/mL/min in arterial compliance, 3 mL.min-1.100 mL forearm-1 in forearm bloodflow, and8 mmHg in diastolic blood pressure. ..
- VOLTAGE-GATED PROTON CHANNELS IN ALVEOLAR EPITHELIUMTHOMAS DECOURSEY; Fiscal Year: 2003..Demonstration that H+ current fluctuations result from stochastic gating of H+ channels will provide strong evidence that the molecule is an ion channel rather than a carrier. ..
- EXOCYTOSIS: USING NANOSURGERY AND BIOENGINEERINGBHANU JENA; Fiscal Year: 2003..These studies will further our understanding of the exocytotic fusion machinery in pancreatic acinar cells, contributing to our understanding of this vital cellular process. ..
- GORDON RESEARCH CONFERENCE ON IN VIVO MAGNETIC RESONANCEChristopher Sotak; Fiscal Year: 2004..Junior investigators will be included in the oral presentations. A special effort will be made to use financial student support to facilitate the attendance of women, minorities, and the disabled. ..
- SODIUM IMAGING IN ISCHEMIC HEART DISEASEPAUL BOTTOMLEY; Fiscal Year: 2002..The availability of thousands of clinical MRI scanners offers a great opportunity for advancing 23Na MRI as a tool for assessing sodium pump function in human heart disease. ..
- MODULATION OF CONNEXIN CHANNEL ACTIVITYAndrew Harris; Fiscal Year: 2002..Such defects will result in abnormal (i.e., greater or lesser) intercellular signaling molecules. The proposed studies address how this may occur. ..
- Colon Barrier Breakdown in the ElderlyJames Mullin; Fiscal Year: 2005..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..
- NUMERICAL SIMULATION OF CARDIAC ELECTROPHYSIOLOGYBradley Roth; Fiscal Year: 2005..Each hypothesis is motivated by experimental data, and the goal of the theoretical simulations is to interpret these data. ..
- ELECTROCHEMICAL IMMUNOASSAYS FOR CARDIAC PROTEINSErno Lindner; Fiscal Year: 2008..Milestone: Test MAIAs in standard serum samples. (4) Test the multi-analyte immunoassay in patient samples. Milestone: Validate the novel MAIAs. [unreadable] [unreadable] [unreadable]..
- Soy Isoflavone Supplementation and Mammographic Density in Postmenopausal WomenWilliam Wong; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MR Studies of Myocardial Creatine Kinase MetabolismPAUL BOTTOMLEY; Fiscal Year: 2007....
- Ca2+ Sparks as Regulators of Airway ContractilityRonghua Zhuge; Fiscal Year: 2007..We expect that these studies will provide new knowledge which could lead to development of novel therapeutic approaches for asthma and other bronchospasitc disorders. ..
- MOLECULAR PHYSIOLOGY OF BAND 3 LIKE PROTEINS OF KIDNEYSeth Alper; Fiscal Year: 2007..5. Define aspects of transcriptional and translational regulation of AE gene products in kidney of mutant and parental mouse strains and in cultured kidney cells. ..
- Biosensor for Contaminant-Free PlateletsEdward Elson; Fiscal Year: 2002..abstract_text> ..
- PROPERTIES OF CONNEXIN CHANNELS THAT CAUSE DEAFNESSAndrew Harris; Fiscal Year: 2006..The information obtained will be informative regarding connexin channel function in other contexts, and will lead to insights about mechanisms of selectivity among cytoplasmic permeants. ..
- Neuronal variability and invariantsAdam Taylor; Fiscal Year: 2006..This work will provide important insights about how nervous systems regulate themselves to maintain proper function. ..
- UNDERSTANDING MEMBRANE FUSION A BIOENGINEERING APPROACHBHANU JENA; Fiscal Year: 2001..The biochemical composition of the "new structure" will be determined by microsequencing electrophoretically resolved proteins immunoisolated from brain tissue, using antibodies to the SNARE proteins. ..