Genomes and Genes
Summary: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Publications346 found, 100 shown here
- CONSORT statement: extension to cluster randomised trialsMarion K Campbell
Health Services Research Unit, University of Aberdeen, Aberdeen, AB25 2ZD
BMJ 328:702-8. 2004
- Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaborationIsabelle Boutron
INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
Ann Intern Med 148:295-309. 2008..This extension, in conjunction with the main CONSORT Statement and other CONSORT extensions, should help to improve the reporting of RCTs performed in this field...
- Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trialsJelena Savovic
School of Social and Community Medicine, University of Bristol, Bristol, UK
Ann Intern Med 157:429-38. 2012..Bias associated with study design characteristics may lead to exaggeration of intervention effect estimates and increases in between-trial heterogeneity in trials reporting subjectively assessed outcomes...
- Review: a gentle introduction to imputation of missing valuesA Rogier T Donders
Center for Biostatistics, Utrecht University, Utrecht, The Netherlands
J Clin Epidemiol 59:1087-91. 2006..We also explain and illustrate why two frequently used methods to handle missing data, i.e., overall mean imputation and the missing-indicator method, almost always result in biased estimates...
- Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policySean R Tunis
Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
JAMA 290:1624-32. 2003..For these changes to occur, clinical and health policy decision makers will need to become more involved in all aspects of clinical research, including priority setting, infrastructure development, and funding...
- CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trialsKenneth F Schulz
Family Health International, Research Triangle Park, North Carolina 27709, USA
Ann Intern Med 152:726-32. 2010..Schulz and colleagues describe the latest version, CONSORT 2010, which updates the reporting guideline based on new methodological evidence and accumulating experience...
- Why most published research findings are falseJohn P A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
PLoS Med 2:e124. 2005..In this essay, I discuss the implications of these problems for the conduct and interpretation of research...
- CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trialsKenneth F Schulz
Family Health International, Research Triangle Park, NC 27709, USA
BMC Med 8:18. 2010..com and will also be published in the Lancet, Obstetrics and Gynecology, PLoS Medicine, Annals of Internal Medicine, Open Medicine, Journal of Clinical Epidemiology, BMC Medicine, and Trials...
- The estimation of a preference-based measure of health from the SF-12John E Brazier
Health Economics and Decision Science Group, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
Med Care 42:851-9. 2004..It has become widely used in clinical trials and routine outcome assessment because of its brevity and psychometric performance, but it cannot be used in economic evaluation in its current form...
- SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trialsAn Wen Chan
Women s College Research Institute at Women s College Hospital, Department of Medicine, University of Toronto, Toronto, Canada M5G 1N8
BMJ 346:e7586. 2013..Complete documentation of key trial elements can facilitate transparency and protocol review for the benefit of all stakeholders...
- Reported methodologic quality and discrepancies between large and small randomized trials in meta-analysesL L Kjaergard
Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
Ann Intern Med 135:982-9. 2001..To explore whether reported methodologic quality affects estimated intervention effects in randomized trials and contributes to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses...
- Increasing response rates to postal questionnaires: systematic reviewPhil Edwards
CRASH Trial Co ordinating Centre, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1B 1DP
BMJ 324:1183. 2002..To identify methods to increase response to postal questionnaires...
- Design and analysis of pilot studies: recommendations for good practiceGillian A Lancaster
Department of Mathematical Sciences, University of Liverpool, UK
J Eval Clin Pract 10:307-12. 2004..It will also safeguard against pilot studies being conducted simply because of small numbers of available patients...
- A tutorial on pilot studies: the what, why and howLehana Thabane
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, Canada
BMC Med Res Methodol 10:1. 2010....
- A call for transparent reporting to optimize the predictive value of preclinical researchStory C Landis
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
Nature 490:187-91. 2012..Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress...
- Improving the reporting of pragmatic trials: an extension of the CONSORT statementMerrick Zwarenstein
Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
BMJ 337:a2390. 2008..In the meantime we recommend that those who support, conduct, and report pragmatic trials should use this extension of the CONSORT statement to facilitate the use of trial results in decisions about health care...
- Systematic reviews of diagnostic test accuracyMariska M G Leeflang
Dutch Cochrane Centre and Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Ann Intern Med 149:889-97. 2008..Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research...
- Comparison of two methods to detect publication bias in meta-analysisJaime L Peters
Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, England
JAMA 295:676-80. 2006..However, the performance of this test and the usual funnel plot have been challenged particularly when the summary estimate is the natural log of the odds ratio (lnOR)...
- Outcome criteria in smoking cessation trials: proposal for a common standardRobert West
University College, London, UK
Addiction 100:299-303. 2005....
- Increasing value and reducing waste in research design, conduct, and analysisJohn P A Ioannidis
Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA Division of Epidemiology, School of Medicine, Stanford University, Stanford, CA, USA Department of Statistics, School of Humanities and Sciences, Stanford University, Stanford, CA, USA Meta Research Innovation Center at Stanford METRICS, Stanford University, Stanford, CA, USA Electronic address
Lancet 383:166-75. 2014....
- What is missing from descriptions of treatment in trials and reviews?Paul Glasziou
Centre for Evidence Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
BMJ 336:1472-4. 2008
- Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?D Moher
Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
Lancet 352:609-13. 1998..We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs)...
- The effectiveness of Web-based vs. non-Web-based interventions: a meta-analysis of behavioral change outcomesDean J Wantland
Department of Community Health Systems, University of California, San Francisco, N531M, School of Nursing, San Francisco CA 94143, USA
J Med Internet Res 6:e40. 2004..The use and effectiveness of Web-based interventions to encourage an individual's change in behavior compared to non-Web-based interventions have not been substantially reviewed...
- Individual determinants of research utilization by nurses: a systematic review updateJanet E Squires
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Implement Sci 6:1. 2011..Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions...
- The prevalence of comorbid depression in adults with diabetes: a meta-analysisR J Anderson
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
Diabetes Care 24:1069-78. 2001..b>RESEARCH DESIGN AND METHODS--MEDLINE and PsycINFO databases and published references were used to identify studies that ..
- Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa)Per Magnus
Division of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway
Int J Epidemiol 35:1146-50. 2006
- Pragmatic controlled clinical trials in primary care: the struggle between external and internal validityMarshall Godwin
Centre for Studies in Primary Care, Queen s University, Kingston K7L 5E9, Canada
BMC Med Res Methodol 3:28. 2003..We describe the design of the trials and the steps taken to deal with the competing demands of external and internal validity...
- REporting recommendations for tumour MARKer prognostic studies (REMARK)L M McShane
US National Cancer Institute, Bethesda, MD 20892, USA
Br J Cancer 93:387-91. 2005....
- Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Pain 9:105-21. 2008..Provisional benchmarks for identifying clinically important changes in specific outcome measures that can be used for outcome studies of treatments for chronic pain are proposed...
- Sample size requirements for association studies of gene-gene interactionW James Gauderman
Department of Preventive Medicine, School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90089, USA
Am J Epidemiol 155:478-84. 2002..A software program that computes sample size for studies of G x G interaction and for studies of gene-environment (G x E) interaction is freely available (http://hydra.usc.edu/gxe)...
- Patterns of intra-cluster correlation from primary care research to inform study design and analysisGeoffrey Adams
Department of Public Health Sciences, King s College London, Capital House, 42 Weston Street, London SE1 3QD, UK
J Clin Epidemiol 57:785-94. 2004..To provide information concerning the magnitude of the intraclass correlation coefficient (ICC) for cluster-based studies set in primary care...
- Evaluation of networks of randomized trialsGeorgia Salanti
Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
Stat Methods Med Res 17:279-301. 2008..Finally, we discuss the implications of inconsistency, network geometry and asymmetry in informing the planning of future trials...
- Scales to assess the quality of randomized controlled trials: a systematic reviewSusan Armijo Olivo
University of Alberta, 3 50 Corbett Hall, Edmonton, Alberta, Canada, T6G 2G4
Phys Ther 88:156-75. 2008..The purpose of this systematic review was to identify scales used to evaluate the methodological quality of RCTs in health care research and summarize the content, construction, development, and psychometric properties of these scales...
- The RE-AIM framework for evaluating interventions: what can it tell us about approaches to chronic illness management?R E Glasgow
AMC Cancer Research Center, Center for Behavioral and Community Studies, 1600 Pierce Street, Denver, CO 80214, USA
Patient Educ Couns 44:119-27. 2001..The RE-AIM framework is used as a method of systematically considering the strengths and weaknesses of chronic illness management interventions in order to guide program planning...
- CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trialsKenneth F Schulz
Family Health International, Research Triangle Park, NC 27709, USA
Trials 11:32. 2010..com and will also be published in the Lancet, Obstetrics and Gynecology, PLoS Medicine, Annals of Internal Medicine, Open Medicine, Journal of Clinical Epidemiology, BMC Medicine, and Trials...
- Data quality of general practice electronic health records: the impact of a program of assessments, feedback, and trainingMark Porcheret
Primary Care Sciences Research Centre, Keele University, UK
J Am Med Inform Assoc 11:78-86. 2004..The aim of this study was to investigate the impact of a program of repeated assessments, feedback, and training on the quality of coded clinical data in general practice...
- Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus reportLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Am Geriatr Soc 52:625-34. 2004....
- Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis methodSandra M Eldridge
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
Int J Epidemiol 35:1292-300. 2006..This can affect trial power, but standard sample size formulae for these trials ignore this. Previous studies addressing this issue have mostly focused on continuous outcomes or methods that are sometimes difficult to use in practice...
- Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological studyFujian Song
Faculty of Medicine and Health Science, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
BMJ 343:d4909. 2011..To investigate the agreement between direct and indirect comparisons of competing healthcare interventions...
- Evaluating the relevance, generalization, and applicability of research: issues in external validation and translation methodologyLawrence W Green
University of California at San Francisco, USA
Eval Health Prof 29:126-53. 2006....
- Remission in schizophrenia: proposed criteria and rationale for consensusNancy C Andreasen
Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
Am J Psychiatry 162:441-9. 2005..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
- What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type modelsMichael A Babyak
Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 66:411-21. 2004..Techniques that account and correct for complexity, including shrinkage and penalization, also are introduced...
- Towards systematic reviews that inform health care management and policy-makingJohn Lavis
Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada
J Health Serv Res Policy 10:35-48. 2005..To identify ways to improve the usefulness of systematic reviews for health care managers and policy-makers that could then be evaluated prospectively...
- Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiativePatrick M Bossuyt
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, Netherlands
BMJ 326:41-4. 2003..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy, to allow readers to assess the potential for bias in a study, and to evaluate a study's generalisability...
- Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD InitiativePatrick M Bossuyt
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
Ann Intern Med 138:40-4. 2003..To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors...
- Designing and evaluating complex interventions to improve health careNeil C Campbell
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen AB25 2AY
BMJ 334:455-9. 2007
- Design and analysis of stepped wedge cluster randomized trialsMichael A Hussey
Fred Hutchinson Cancer Research Center, Seattle, WA, United States
Contemp Clin Trials 28:182-91. 2007..In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use...
- How can we increase translation of research into practice? Types of evidence neededRussell E Glasgow
Kaiser Permanente Colorado, Denver, CO 80231, USA
Annu Rev Public Health 28:413-33. 2007..Greater attention is needed to connectedness across program levels and components. Finally, examples are provided of evaluation models and current programs that can help accelerate translation of research to practice and policy...
- Why don't we see more translation of health promotion research to practice? Rethinking the efficacy-to-effectiveness transitionRussell E Glasgow
Kaiser Permanente Colorado, USA
Am J Public Health 93:1261-7. 2003..Recommendations are offered to help close the gap between efficacy and effectiveness research and to guide evaluation and possible adoption of new programs...
- Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviewsFujian Song
Faculty of Health, University of East Anglia, Norwich NR4 7TJ
BMJ 338:b1147. 2009..To investigate basic assumptions and other methodological problems in the application of indirect comparison in systematic reviews of competing healthcare interventions...
- Indirect comparisons of competing interventionsA M Glenny
Cochrane Oral Health Group, Dental School, University of Manchester, UK
Health Technol Assess 9:1-134, iii-iv. 2005....
- Credibility of claims of subgroup effects in randomised controlled trials: systematic reviewXin Sun
Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA
BMJ 344:e1553. 2012..To investigate the credibility of authors' claims of subgroup effects using a representative sample of recently published randomised controlled trials...
- Pragmatic clinical trialsHugh MacPherson
Foundation for Traditional Chinese Medicine, York, UK
Complement Ther Med 12:136-40. 2004..A case is made for the appropriate use and relevance of pragmatic trials in the evaluation of alternative and complementary medicine...
- The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMedSally Hopewell
Centre for Statistics in Medicine, University of Oxford, Linton Road, Oxford OX2 6UD
BMJ 340:c723. 2010....
- Survey of the quality of experimental design, statistical analysis and reporting of research using animalsCarol Kilkenny
The National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, United Kingdom
PLoS ONE 4:e7824. 2009....
- The science of improvementDonald M Berwick
Institute for Healthcare Improvement, Cambridge, Massachusetts 02138, USA
JAMA 299:1182-4. 2008
- Methods for the synthesis of qualitative research: a critical reviewElaine Barnett-Page
Evidence for Policy and Practice Information and Co ordinating Centre, Social Science Research Unit, 18 Woburn Square, London WC1H 0NS, UK
BMC Med Res Methodol 9:59. 2009..There is a need for both researchers and commissioners to be able to distinguish between these methods and to select which method is the most appropriate to their situation...
- Good research practices for cost-effectiveness analysis alongside clinical trials: the ISPOR RCT-CEA Task Force reportScott Ramsey
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Value Health 8:521-33. 2005..Its goal was to develop a guidance document for designing, conducting, and reporting cost-effectiveness analyses conducted as a part of clinical trials...
- Quality improvement report: Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. Commentary: presenting unbiased information to patients can be difficultJenny Donovan
Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
BMJ 325:766-70. 2002..Recruitment to randomised trials is often difficult, and many important trials are not mounted because recruitment is thought to be "impossible."..
- Enhancing treatment fidelity in health behavior change studies: best practices and recommendations from the NIH Behavior Change ConsortiumAlbert J Bellg
Appleton Cardiology Associates, Appleton Heart Institute, Appleton, WI 54911, USA
Health Psychol 23:443-51. 2004..Funding agencies, reviewers, and journal editors are encouraged to make treatment fidelity a standard part of the conduct and evaluation of health behavior intervention research...
- Good laboratory practice: preventing introduction of bias at the benchMalcolm R Macleod
Centre for Clinical Brain Sciences, University of Edinburgh, UK
Stroke 40:e50-2. 2009....
- When is informed consent required in cluster randomized trials in health research?Andrew D McRae
Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON N6A5C1, Canada
Trials 12:202. 2011..Fifth, while health professionals may have a moral obligation to participate as subjects in research, this does not diminish the necessity of informed consent to study participation...
- Improving the translational hit of experimental treatments in multiple sclerosisHanna M Vesterinen
Centre for Clinical Brain Sciences, Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
Mult Scler 16:1044-55. 2010..In other neurological diseases, the failure to translate pre-clinical findings to effective clinical treatments has been partially attributed to bias introduced by shortcomings in the design of animal experiments...
- The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviewsJamie J Kirkham
Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool L69 3GS
BMJ 340:c365. 2010..To examine the prevalence of outcome reporting bias-the selection for publication of a subset of the original recorded outcome variables on the basis of the results-and its impact on Cochrane reviews...
- How to track and assess genotyping errors in population genetics studiesA Bonin
Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 09, France
Mol Ecol 13:3261-73. 2004....
- Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groupsMary Dixon-Woods
Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
BMC Med Res Methodol 6:35. 2006..This approach is sensitised to the processes of conventional systematic review methodology and draws on recent advances in methods for interpretive synthesis...
- No surgical innovation without evaluation: the IDEAL recommendationsPeter McCulloch
Nuffield Department of Surgery, University of Oxford, Oxford, UK
Lancet 374:1105-12. 2009..Achievement of improved design, conduct, and reporting of surgical research will need concerted action by editors, funders of health care and research, regulatory bodies, and professional societies...
- Missing data analysis: making it work in the real worldJohn W Graham
Department of Biobehavioral Health and the Prevention Research Center, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Annu Rev Psychol 60:549-76. 2009..Suggestions are given for moving forward with research on missing data and attrition...
- A comparison of bayesian methods for haplotype reconstruction from population genotype dataMatthew Stephens
Department of Statistics, University of Washington, Seattle, WA 98195 4322, USA
Am J Hum Genet 73:1162-9. 2003..The new algorithm is included in the software package PHASE, version 2.0, available online (http://www.stat.washington.edu/stephens/software.html)...
- Interrupted time series designs in health technology assessment: lessons from two systematic reviews of behavior change strategiesCraig R Ramsay
Health Services Research Unit, University of Aberdeen, Foresterhill, UK
Int J Technol Assess Health Care 19:613-23. 2003..We critically reviewed the methodological quality of ITS designs using studies included in two systematic reviews (a review of mass media interventions and a review of guideline dissemination and implementation strategies)...
- Systems biology: experimental designClemens Kreutz
Physics Department, University of Freiburg, Germany
FEBS J 276:923-42. 2009..Furthermore, the relevant classical aspects of experimental design, such as randomization, replication and confounding, are reviewed...
- Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatmentsIsabelle Boutron
INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
Ann Intern Med 148:W60-6. 2008..The conduct of randomized, controlled trials of nonpharmacologic treatments presents specific challenges that are not adequately addressed in trial reports...
- A process for systematically reviewing the literature: providing the research evidence for public health nursing interventionsB H Thomas
McMaster University School of Nursing, Hamilton Public Health and Community Services, Ontario, Canada
Worldviews Evid Based Nurs 1:176-84. 2004..Also, the project is expected to disseminate the results provincially, nationally, and internationally. Most of the reviews are relevant to public health nursing practice...
- Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic reviewS Barry Issenberg
Center for Research in Medical Education, University of Miami School of Medicine, Miami, FL 33101, USA
Med Teach 27:10-28. 2005..1969 to 2003, 34 years...
- Describing reporting guidelines for health research: a systematic reviewDavid Moher
Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
J Clin Epidemiol 64:718-42. 2011..To describe the process of development, content, and methods of implementation of reporting guidelines for health research...
- Imputation of missing values is superior to complete case analysis and the missing-indicator method in multivariable diagnostic research: a clinical exampleGeert J M G van der Heijden
Julius Center for Health Sciences and Primary Care, University Medical Center, P O Box 80035, 3508 GA Utrecht, The Netherlands
J Clin Epidemiol 59:1102-9. 2006....
- The problem of appraising qualitative researchM Dixon-Woods
Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
Qual Saf Health Care 13:223-5. 2004..There will be difficulties in doing this because some aspects of qualitative research, particularly those relating to quality of insight and interpretation, will remain difficult to appraise and will rely largely on subjective judgement...
- Unpredictable bias when using the missing indicator method or complete case analysis for missing confounder values: an empirical exampleMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
J Clin Epidemiol 63:728-36. 2010..Using empirical data, we demonstrated the degree and direction of bias in the effect estimate when using these methods compared with multiple imputation (MI)...
- The effectiveness of clinical guideline implementation strategies--a synthesis of systematic review findingsMathew Prior
Centre for Allied Health Evidence, University of South Australia, Adelaide, Australia
J Eval Clin Pract 14:888-97. 2008..Data sources/study setting Systematic reviews in full text, English language, 1987-2007, reporting any measure of clinical process change or cost-benefit analysis...
- What is "quality of evidence" and why is it important to clinicians?Gordon H Guyatt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
BMJ 336:995-8. 2008
- The STARD statement for reporting studies of diagnostic accuracy: explanation and elaborationPatrick M Bossuyt
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Clin Chem 49:7-18. 2003..Complete and informative reporting can only lead to better decisions in healthcare...
- Evaluation of the quality of prognosis studies in systematic reviewsJill A Hayden
Institute for Work and Health, University of Toronto, and Mount Sinai Hospital, Toronto, Ontario, Canada
Ann Intern Med 144:427-37. 2006..To provide valid assessments of answers to prognostic questions, systematic reviews must appraise the quality of the available evidence. However, no standard quality assessment method is currently available...
- Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?Kristian Thorlund
Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Department 3344, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Int J Epidemiol 38:276-86. 2009..e. applying trial sequential monitoring boundaries)...
- Toward a better understanding of the influences on physical activity: the role of determinants, correlates, causal variables, mediators, moderators, and confoundersAdrian E Bauman
School of Community Medicine and Public Health, University of New South Wales, Sydney, Australia
Am J Prev Med 23:5-14. 2002..This article examines the factors that are correlated with and that may have a causal relationship to physical activity...
- The PARIHS framework--a framework for guiding the implementation of evidence-based practiceJo Rycroft-Malone
Royal College of Nursing Institute, Oxford, United Kingdom
J Nurs Care Qual 19:297-304. 2004
- What makes self-help interventions effective in the management of depressive symptoms? Meta-analysis and meta-regressionJudith Gellatly
Department of Nursing, Midwifery and Health Visiting, University of Manchester, UK
Psychol Med 37:1217-28. 2007..e. moderators of effect). This study sought to determine whether the content of self-help interventions, the study populations or aspects of study design were the most important moderators...
- Good practice in the conduct and reporting of survey researchKate Kelley
Research Department, Worthing and Southland Hospitals NHS Trust, Worthing, West Sussex, UK
Int J Qual Health Care 15:261-6. 2003..It is not intended to provide a manual of how to conduct a survey, but rather to identify common pitfalls and oversights to be avoided by researchers if their work is to be valid and credible...
- Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trialsKausik K Ray
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Lancet 373:1765-72. 2009..We undertook a meta-analysis of randomised controlled trials to determine whether intensive treatment is beneficial...
- The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)--methods and response ratesDavid W Dunstan
The International Diabetes Institute, 250 Kooyong Road, Caulfield, VIC 3162, Australia
Diabetes Res Clin Pract 57:119-29. 2002..Furthermore, it generates the baseline data for a prospective 5-year cohort study. The data will be important for national and regional public health and lifestyle education and health promotion programs...
- A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designersKevin E Thorpe
Dalla Lana School of Public Health, University of Toronto, Ontario, Canada
J Clin Epidemiol 62:464-75. 2009..To propose a tool to assist trialists in making design decisions that are consistent with their trial's stated purpose...
- Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study qualityMalcolm R Macleod
Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
Stroke 39:2824-9. 2008..Animal studies are susceptible to study quality biases, which may lead to overstatement of efficacy. We report the impact of study quality on published estimates of the efficacy of NXY-059 in animal models of stroke...
- Systematic review of the Hawthorne effect: new concepts are needed to study research participation effectsJim McCambridge
Department of Social and Environmental Health, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK Electronic address
J Clin Epidemiol 67:267-77. 2014..This study aims to (1) elucidate whether the Hawthorne effect exists, (2) explore under what conditions, and (3) estimate the size of any such effect...
- Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigationR B D'Agostino
Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
JAMA 286:180-7. 2001..Concern exists regarding whether these functions can be generalized to other populations...
- Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Standards for Reporting of Diagnostic AccuracyPatrick M Bossuyt
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Clin Chem 49:1-6. 2003..To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors...
- Qualitative research: standards, challenges, and guidelinesK Malterud
Section for General Practice, Department of Public Health and Primary Health Care, University of Bergen, Ulriksdal 8c, N 5009, Bergen, Norway
Lancet 358:483-8. 2001....
- Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analysesJesper Brok
Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Cochrane Hepato Biliary Group, Dept 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
J Clin Epidemiol 61:763-9. 2008..Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial...
- Graphical method for depicting randomised trials of complex interventionsRafael Perera
Centre for Evidence Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
BMJ 334:127-9. 2007
- A worked example of "best fit" framework synthesis: a systematic review of views concerning the taking of some potential chemopreventive agentsChristopher Carroll
School of Health and Related Research, University of Sheffield, Sheffield, UK
BMC Med Res Methodol 11:29. 2011..The aim of this paper is to describe the application of a pragmatic method of qualitative evidence synthesis and the lessons learned from adopting this "best fit" framework synthesis approach...
- A cluster randomised controlled trial of the community effectiveness of two interventions in rural Malawi to improve health care and to reduce maternal, newborn and infant mortalitySonia Lewycka
Centre for International Health and Development, UCL Institute of Child Health, London, UK
Trials 11:88. 2010..The MaiMwana Project aims to test community-based interventions that tackle maternal and child health problems through increasing awareness and local action...
- Randomized clinical trials with biomarkers: design issuesBoris Freidlin
Biometric Research Branch, EPN 8122, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 102:152-60. 2010..We conclude that, in most settings, randomized biomarker-stratified designs (ie, designs that use the biomarker to guide analysis but not treatment assignment) should be used to obtain a rigorous assessment of biomarker clinical utility...
- Research guidelines for the Delphi survey techniqueF Hasson
Centre for Nursing Research, University of Ulster, Newtownabbey, Northern Ireland
J Adv Nurs 32:1008-15. 2000..The paper does not claim to be definitive; it purports to act as a guide for those researchers who wish to exploit the Delphi methodology...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Genetic variation and regulatory networks: Mechanisms and complexityDANA PE ER; Fiscal Year: 2009..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator ArraysRyan Bailey; Fiscal Year: 2009..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
- NIH Director's Pioneer AwardERICH JARVIS; Fiscal Year: 2009..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
- High Throughput Genotyping and DNA Sequencing for Studying the Genetic ContributiSonia Dua; Fiscal Year: 2013..The contractor is responsible for providing staff with the credentials required by CLIA. ..
- Chymase-Mediated MMP Activation in Ishemia Reperfusion InjuryLOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013....
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2011..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2012..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
- Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic DiseasStephen C Strom; Fiscal Year: 2010..We propose these humanized mice will be a technology platform to better understand the human disease and it will aid in the development of gene or cellular therapy to correct these devastating diseases. ..
- Optimization of DNA Repair by Abh8Lauren Endres; Fiscal Year: 2013..Overall, these findings will form the basis of future studies into Abh8 regulation during the DDR. ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..We have successfully tested one of these serpins, Serp-1, in a small phase 2A clinical trial for anti-inflammatory activity in unstable coronary syndromes (Viron Therapeutics, Inc;proprietary information). ..
- Vaccine Development for Falciparum Malaria in Pregnant Women and Their OffspringIan C Michelow; Fiscal Year: 2013..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
- Brain Activation responses in adolescents with genetic predisposition to obesitySusan Carnell; Fiscal Year: 2011..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings. ..
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2012..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
- Genome-wide recombination as a risk factor for nondisjunctionNATASHA D HOLLIS; Fiscal Year: 2010..The reference letters are strong. She has the necessary package to excel as a pre-doctoral fellow. ..
- Infant Screening and Diagnosis of Duchenne Muscular Dys*Paul Fernhoff; Fiscal Year: 2007..These data points will be tracked throughout the project. ..
- Tyrosine Availability Influences Mesocortico-Limbic CatecholaminesGEORGE EUGENE JASKIW; Fiscal Year: 2012..Our data will fill in fundamental gaps in our understanding of how brain dopamine systems work. This will help researchers who study these other brain disorders. ..
- Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic DisPATRICIA MASCARELLI; Fiscal Year: 2011..abstract_text> ..
- Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel MutantsJOHN SAMUEL STAHL; Fiscal Year: 2013....
- Regulation of thyroid hormone levels by central and peripheral pathwaysKRISTEN RACHEL VELLA; Fiscal Year: 2013..abstract_text> ..
- Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injuryMaria Lauda Tomasi; Fiscal Year: 2012..Three aims are proposed in this application to test these hypotheses and elucidate how SAMe affects signaling pathways that are important in hepatocarcinogenesis and development of alcoholic liver injury. ..
- Soluble Epoxide Hydrolase as a Target for Ischemic CardioprotectionDonna M Van Winkle; Fiscal Year: 2012..Thus the currently proposed studies are significant in terms of clinical implications for limiting cardiac damage in the vulnerable veteran population and for fiscal health of the Department of Veterans Affairs. ..
- Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBICHARLES WILLIAM WILKINSON; Fiscal Year: 2012..abstract_text> ..
- Neurobehavioral Correlates of Familial/genetic obesity risk in adolescentsSusan Carnell; Fiscal Year: 2013..abstract_text> ..
- Non-viral Genetic Modification of Antigen-presenting Cells in AllograftsWilson S Meng; Fiscal Year: 2011..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
- Neuroimaging abnormalities in major depressive disorder: effect of inflammationJonathan Savitz; Fiscal Year: 2013....
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
- Behavioral Activation Therapy for Rural Veterans with Diabetes and DepressionAanand Dinkar Naik; Fiscal Year: 2013..As therapists are all advanced psychology graduate students, it is unclear whether individuals without such previous training can implement the intervention. This may hamper implementation efforts. ..
- Chronic nicotine and synaptic transmission in brainstem respiratory neuronsRALPH FRANK FREGOSI; Fiscal Year: 2013..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
- Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional IKEVIN ROBERT VINCENT; Fiscal Year: 2013..Joanne Jordan from the University of North Carolina who will help with clinical correlation to OA and research design. In addition to a distinguished and experienced mentoring team, Dr...
- Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related caJose M Garcia; Fiscal Year: 2013..b>Research Design and Methods: In our rodent model of cisplatin-induced cachexia we have observed that ghrelin prevents ..
- METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMENMichael J LaMonte; Fiscal Year: 2013..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2010....
- Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseasesRobert M Weiss; Fiscal Year: 2010..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
- A Soft Topical Antiandrogenic DrugWei Chu Xu; Fiscal Year: 2013..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
- Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trialDavid A Benaron; Fiscal Year: 2010..If successful, the health benefit will be large, as it is estimated that treating NEC alone (not including treating its later complications) adds $650 million to the annual health bill. ..
- Targeting Inflammation for the Amelioration of Cisplatin-Hearing LossVickram Ramkumar; Fiscal Year: 2011..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2009..NICEATM and ICCVAM will also evaluate non-animal methods and approaches for determining the skin irritation potential of antimicrobial cleaning products...
- Group A Streptococcus responses to oxidative stressIoannis Gryllos; Fiscal Year: 2010....
- Preclinical Development of JS-K, a Novel NO-Generating Prodrug for CancerPaul J Shami; Fiscal Year: 2012..This new drug then goes one step further: it will improve the quality of life for cancer patients, their caregivers and families by providing a significantly more effective and less painful therapy than is currently available. ..
- BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINSPi Wan Cheng; Fiscal Year: 2010..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
- Remodeling Neuronal Chromatin in Mouse Models for DepressionSchahram Akbarian; Fiscal Year: 2013..Then, indirectly, the chromatin changes brought about by Setdb1 result in certain adaptations in the communication between nerve cells, ultimately resulting in an antidepressant-like effect. ..
- Targeting superbugs: discovery and development of new broad-spectrum lipopeptidesJian Li; Fiscal Year: 2013..b>Research Design: Using a new structure-activity relationship (SAR)-based mechanistic model for polymyxins, novel lipopeptides ..
- Transgenesis and XenotransplantationJorge A Piedrahita; Fiscal Year: 2013....
- VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-LeadCYNTHIA T MCEVOY; Fiscal Year: 2013..End of Abstract) ..
- Prostate cancer chemoprevention by penta-galloyl-glucoseJunxuan Lu; Fiscal Year: 2013..These multiple targeting activities plus published work supporting anti- angiogenesis activity provide strong rationale for testing the efficacy of PGG for prostate cancer chemoprevention. ..
- Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground MiJefferey L Burgess; Fiscal Year: 2013..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
- Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injuryFREDERIC TREMAINE BILLINGS; Fiscal Year: 2013..Strong institutional investment in the candidate optimizes his likelihood of progressing to independence and impacting on adverse effects of surgery. ..
- Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and AdjuvantsPAUL CAMILLE TUMEH; Fiscal Year: 2013..As a future independent investigator, this system will enable me to collaborate with scientists and clinicians to address a wide scope of challenges in medicine. ..
- Improving TB Diagnosis in Children with and without HIV in KenyaRinn Song; Fiscal Year: 2013....
- Ethanol Regulation of Serum Glucocorticoid Kinase IBLAIR N COSTIN; Fiscal Year: 2012..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
- Systemic Inflammation and Central Nervous System DysfunctionLaura L Dugan; Fiscal Year: 2013..abstract_text> ..
- Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporteAYLIN RACHEL RODAN; Fiscal Year: 2013..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
- Sex Steroid Hormone Regulation of Drug ReinforcementDiane Lebesgue; Fiscal Year: 2012..abstract_text> ..
- Latin American Center for Malaria Research and ControlSOCRATES HERRERA VALENCIA; Fiscal Year: 2013..Data and findings generated by this Center are expected to provide input critical to inform future research design and evaluation of new interventions and control strategies...
- Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanomaANDREW GREGORY SIKORA; Fiscal Year: 2013..abstract_text> ..
- BONE MATRIX AND BONE RESORPTIONPaul R Odgren; Fiscal Year: 2012..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
- Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic ManipulationsPetr Tvrdik; Fiscal Year: 2013..We will be able to determine if Hoxb8 mutant microglia respond to neural stimuli correctly. Taken together, the proposed work will advance the set of tools available to address the underlying causes of glial and other disorders. ..
- Analyzer for Monitoring Personal Environmental Exposure to Fluids and MaterialsMATTHEW CUSACK; Fiscal Year: 2010..Other applications for this technology are expected to be part of the GEI, the National Children's Study (NCS), in workplace assessments of occupational exposure, hospitals, or other medical or research settings. ..
- Bioconductor: an open computing resource for genomicsMartin Morgan; Fiscal Year: 2010..While that type of "success measure" is hard to assess, more effort in this area in subsequent proposals would be helpful. ..
- Intracellular Phase Diagram Creation Using a Micro-Differential Scanning CalorimeGARY L SOLBREKKEN; Fiscal Year: 2010..We will test the new machine on mouse oocytes, mouse and rat embryos, and zebrafish embryos. ..
- Integrated MRI-Based Examination for Evaluation of Peripheral Arterial DiseaseFelix W Wehrli; Fiscal Year: 2010....
- Economic Consequences of Advanced Testing for Subclinical Cardiovascular DiseaseLeslee J Shaw; Fiscal Year: 2010..We will compare costs in addition to the added benefit of improved detection of heart disease risk using several cardiac biomarkers. ..
- Exercise-Facilitated NeuroRehabilitation in Diabetic NeuropathyEVAN STUBBS; Fiscal Year: 2009..With an aging Veteran population, the number of diabetic neuropathic patients in need of VA medical services is expected to increase considerably. ..
- Bioassay for Breast Cancer PreventionJoEllen Welsh; Fiscal Year: 2010....
- Novel Use of Confocal Microscopy on Cultured Porcine Corneas for Pre-Clinical TesMichelle Piehl; Fiscal Year: 2011..This would reduce overall product development cost and human test subject pain and distress while promoting robust product safety for public health. ..
- Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB InfectionsLisa Maragakis; Fiscal Year: 2009..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
- WI State Public Health Lab Capacity for SCID ScreeningCHARLES DENNIS BROKOPP; Fiscal Year: 2010..Our SCID-NBS program will not only produce essential baseline data (i.e. incidence rates in the target population), it will detect SCID afflicted newborns born in year 01 through 03. ..
- ATYPICAL ODONTALGIA AND ENDODONTIC TREATMENT, SENSORY TESTING AND GENETIC STUDYEli Eliav; Fiscal Year: 2010..This exploratory study results may serve as the ground for a further study that will evaluate more patients prior to the procedure, will study predisposing factors and will help predict treatment outcome. ..
- Risk of Cancer with Incidental Findings Identified on Ultrasound ImagingRebecca Smith Bindman; Fiscal Year: 2010..The goal is to develop management strategies for these incidental findings that will maximize the detection of occult cancer, while minimizing unnecessary imaging surveillance. ..
- Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB InfectionsLisa Saiman; Fiscal Year: 2009..The research design is a prospective observational study of ICU patients with hospital-acquired pneumonia and bloodstream ..
- Echinacea: Standardized Product & Supply ProvisionXiping Wang; Fiscal Year: 2004..abstract_text> ..
- Testing a Measurement Model of Acute DyspneaMark Parshall; Fiscal Year: 2005....