conditioning psychology

Summary

Summary: A general term referring to the learning of some particular response.

Top Publications

  1. ncbi [Good response to ganciclovir in a patient of cytomegalovirus (CMV) interstitial pneumonitis and gastric ulcer following allogeneic bone marrow transplantation for acute lymphoblastic leukemia]
    S Mizuno
    Bone Marrow Transplantation Group of Miyazaki Prefectural Hospital
    Kansenshogaku Zasshi 69:213-7. 1995
  2. ncbi Prevalence of nightmares and their relationship to psychopathology and daytime functioning in insomnia subjects
    M M Ohayon
    Centre de Recherche Philippe Pinel de Montreal, Quebec, Canada
    Sleep 20:340-8. 1997
  3. ncbi [Epoetin alfa in radiotherapy]
    L Trodella
    Divisione di Radioterapia, , Roma
    Tumori 84:S15-9. 1998
  4. ncbi Determination of albendazole and its main metabolites in ovine plasma by liquid chromatography with dialysis as an integrated sample preparation technique
    P Chiap
    Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, , Belgium
    J Chromatogr A 870:121-34. 2000
  5. ncbi Risk of basal and squamous cell carcinomas of the skin in Sion, Switzerland: a case-control study
    S Rosso
    CPO Registro Tumori Piemonte, Turin, Italy
    Tumori 85:435-42. 1999
  6. pmc Regulation of neural responses in the canine pyloric sphincter by opioids
    O Bayguinov
    Department of Physiology, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 108:1024-30. 1993
  7. ncbi Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: blockade by coincident inhibition of protein kinase A
    M A Sutton
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 11:365-76. 2000
  8. pmc Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical University, Japan
    Br J Pharmacol 110:1142-8. 1993
  9. pmc Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons
    B Everill
    Department of Neurology, Yale University School of Medicine, CT 06510, New Haven, USA
    Neuroscience 100:417-22. 2000
  10. ncbi [Autologous peripheral blood selected CD34+ cell transplantation in the treatment of multiple myeloma]
    X Tang
    First Affiliated Hospital of Suzhou University, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 22:370-3. 2001

Detail Information

Publications270 found, 100 shown here

  1. ncbi [Good response to ganciclovir in a patient of cytomegalovirus (CMV) interstitial pneumonitis and gastric ulcer following allogeneic bone marrow transplantation for acute lymphoblastic leukemia]
    S Mizuno
    Bone Marrow Transplantation Group of Miyazaki Prefectural Hospital
    Kansenshogaku Zasshi 69:213-7. 1995
    ..Although leukocytopenia was significant for this patient, ganciclovir is considered to be useful for controlling CMV infection in both the lungs and stomach...
  2. ncbi Prevalence of nightmares and their relationship to psychopathology and daytime functioning in insomnia subjects
    M M Ohayon
    Centre de Recherche Philippe Pinel de Montreal, Quebec, Canada
    Sleep 20:340-8. 1997
    ....
  3. ncbi [Epoetin alfa in radiotherapy]
    L Trodella
    Divisione di Radioterapia, , Roma
    Tumori 84:S15-9. 1998
    ..Keeping in mind that grade 1 minimum toxicity for red cells, according to the Radiation Therapy Oncology Group (RTOG) is equal to 11 gHb/dL we think that this value can be considered as cutoff to start erythropoietin therapy...
  4. ncbi Determination of albendazole and its main metabolites in ovine plasma by liquid chromatography with dialysis as an integrated sample preparation technique
    P Chiap
    Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, , Belgium
    J Chromatogr A 870:121-34. 2000
    ..The mean recoveries for albendazole and its metabolites were about 70 and 65%, respectively. The limits of quantification for albendazole and its metabolites were 10 and 7.5 ng/ml, respectively...
  5. ncbi Risk of basal and squamous cell carcinomas of the skin in Sion, Switzerland: a case-control study
    S Rosso
    CPO Registro Tumori Piemonte, Turin, Italy
    Tumori 85:435-42. 1999
    ....
  6. pmc Regulation of neural responses in the canine pyloric sphincter by opioids
    O Bayguinov
    Department of Physiology, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 108:1024-30. 1993
    ..Higher frequency stimulation (or longer durations of stimulation) appear to be necessary to release concentrations of opioids that are effective in modulating the amplitude of junction potentials...
  7. ncbi Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: blockade by coincident inhibition of protein kinase A
    M A Sutton
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 11:365-76. 2000
    ..These results demonstrate that the activation of PKA plays a critical role in the process by which properties of drugs become associated with environmental stimuli...
  8. pmc Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical University, Japan
    Br J Pharmacol 110:1142-8. 1993
    ..The present study further provides evidence for the involvement of SP and NKA in the slow ventral root depolarization and the prolonged inhibition of monosynaptic reflex that are evoked by primary afferent stimulation...
  9. pmc Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons
    B Everill
    Department of Neurology, Yale University School of Medicine, CT 06510, New Haven, USA
    Neuroscience 100:417-22. 2000
    ..These results indicate that the large reduction in transient A-current, and in sustained K-current, observed in cutaneous afferent cell bodies after nerve ligation is prevented by application of nerve growth factor...
  10. ncbi [Autologous peripheral blood selected CD34+ cell transplantation in the treatment of multiple myeloma]
    X Tang
    First Affiliated Hospital of Suzhou University, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 22:370-3. 2001
    ..Furthermore, unselected APBSCT could reduce the cost for the transplantation. CONCLUSION: It shows that CD(34)(+) cell selected autologous transplantation is more expensive and does not improve the clinical outcome of patients with MM...
  11. ncbi Modified conditioning regimen busulfan-cyclophosphamide followed by allogeneic stem cell transplantation in patients with multiple myeloma
    Xiao hui Zhang
    Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 120:463-8. 2007
    ..In this study the toxicity and efficacy of modified myeloablative conditioning regimen followed by allogeneic stem cell transplantation was investigated in patients with multiple myeloma...
  12. ncbi [Exposure of the pediatric surgeon to inhalation-anesthetic during pediatric bronchoscopy procedures]
    K Westphal
    ,
    Pneumologie 51:1123-6. 1997
    ..Therefore, in case of such working conditions, the use of total intravenous anaesthesia is advocated also in very small infants...
  13. pmc Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
    K L Lankford
    Department of Neurology, Yale University School of Medicine, Veterans Affairs Medical Center, West Haven, Connecticut 06515, USA
    J Comp Neurol 391:11-29. 1998
    ..A secondary effect of conditioning lesions on neurite outgrowth rates was dependent on the local environment of the axons prior to culturing...
  14. pmc Desensitization of histamine H1 receptor-mediated inositol phosphate accumulation in guinea pig cerebral cortex slices
    D R Bristow
    Department of Physiological Sciences, University of Manchester
    Br J Pharmacol 110:269-74. 1993
    ..The desensitized histamine-stimulated [3H]-inositol phosphate accumulation recovered to 90% of control levels over a period of 150 min after the removal of the conditioning dose of histamine, with a half-time of recovery of about 95 min...
  15. ncbi [An outbreak of Pontiac fever due to Legionella pneumophila serogroup 7. II. Epidemiological aspects]
    E Yabuuchi
    Department of Bacteriology, Osaka City University Medical School
    Kansenshogaku Zasshi 69:654-65. 1995
    ..pneumophila to overly multiply, which could be a source of infection by flowing in through opened windows to the training rooms...
  16. ncbi Novel, trifunctional diamine for silica coating in capillary zone electrophoresis
    R Sebastiano
    Department of Chemistry, Politecnico of Milano, Milan, Italy
    J Chromatogr A 894:53-61. 2000
    ....
  17. ncbi Allogeneic bone marrow transplantation. Recent developments and the potential expansion of the donor pool
    H G Prentice
    Bone Marrow Transplant Programme, Royal Free Hospital and Medical School, Hampstead, England
    Acta Oncol 27:567-70. 1988
    ..Of further interest will be the potential for application of lymphokines (e.g. IL2) without increasing the risk of lethal graft versus host disease...
  18. ncbi [Lack of air conditioning and mycotoxin poisoning are basic co-factors in tropical spastic paraparesis]
    F E León
    Department of Neurology, University of Alabama at Birmingham, USA
    Rev Neurol 26:564-7. 1998
    ..Chronic idiopathic spastic paraparesis (CHISPA) have been associated to HTLV-I virus infection, and unknown environmental factors have been suggested to play a role in its pathogenesis...
  19. ncbi Intense peripheral electrical stimulation differentially inhibits tail vs. limb withdrawal reflexes in the rat
    V V Romita
    Department of Psychiatry, McGill University, Montreal, Que, Canada
    Brain Res 720:45-53. 1996
    ..The persistent inhibition appears to be dependent on the site of stimulation because it is not evoked by stimulation of sites outside of meridian points...
  20. ncbi What is the possible contribution of Ca2+-stimulated adenylate cyclase to acquisition, consolidation and retention of an associative olfactory memory in Drosophila
    Y Dudai
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Comp Physiol A 162:101-9. 1988
    ....
  21. ncbi Unexpected surface chemistry in capillaries for electrophoresis
    S Kaupp
    Leibniz-lnstitut for Spectrochemistry and Applied Spectroscopy, Dortmund, Germany
    J Chromatogr A 894:73-7. 2000
    ..A better understanding of the surface chemistry should not only improve robustness in CE, but also help to facilitate and accelerate capillary pre-conditioning and rinsing procedures to remove strongly adsorbed analytes or matrices...
  22. ncbi Pseudomonas aeruginosa lectins as a model for lectin production, properties, applications and functions
    N Gilboa Garber
    Department of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Zentralbl Bakteriol Mikrobiol Hyg A 270:3-15. 1988
    ....
  23. ncbi Healing of periodontal defects treated with enamel matrix proteins and root surface conditioning--an experimental study in dogs
    Umur Sakallioglu
    Faculty of Dentistry, Department of Periodontology, Ondokuz Mayis University, Kurupelit, 55139, Samsun, Turkey
    Biomaterials 25:1831-40. 2004
    ..An acellular type of cementum regeneration and new alveolar bone formation by an accelerated osteoconductive mechanism are also achieved with application of enamel matrix proteins...
  24. ncbi [Effects of allogeneic hematopoietic stem cell transplantation with very-high-dose conditioning regimen for refractory leukemia]
    Qi Fa Liu
    Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:1117-9. 2004
    ....
  25. ncbi A new paradigm for operant conditioning of Drosophila melanogaster
    G Wustmann
    , , , Germany
    J Comp Physiol A 179:429-36. 1996
    ..3) The procedure is fast, robust and requires little handling. Therefore the apparatus is suitable for largescale mutant screening. (4) Animals are not attached to a hook and thus can easily be used for breeding...
  26. ncbi [The amigdaloid body: functional implications]
    M Torras
    , , Universitad Autonoma de Barcelona Barcelona,
    Rev Neurol 33:471-6. 2001
    ..However, the lateral and central nuclei participate in emotional learning whilst the basolateral nucleus is especially involved in modulation of the memory when emotional activation occurs...
  27. ncbi Transplantation of bone marrow and peripheral stem cells
    T Alvegard
    Department of Oncology, Lund, Sweden
    Acta Oncol 35:137-40. 1996
    ..For many other hematological malignancies at less advanced stages, conditioning methods are probably of equal value...
  28. ncbi [A prospective and randomized study of two conditioning regimens in treatment of severe systemic autoimmune diseases with autologous peripheral blood stem cell transplantation]
    Wei Zhang
    Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 87:1689-92. 2007
    ....
  29. ncbi Allogeneic stem cell transplantation after a fludarabine/busulfan-based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Ann Hematol 82:336-42. 2003
    ....
  30. ncbi Behavioral and neurochemical components of nicotine sensitization following 15-day pretreatment: studies on contextual conditioning
    M S Reid
    Department of Psychiatry, University of California San Francisco, San Francisco Veterans Affairs Medical Center, 94121, USA
    Behav Pharmacol 9:137-48. 1998
    ..Each of these responses to nicotine were differentially modulated by contextual conditioning. It is suggested that nicotine-stimulated dopamine release in sensitized animals represents the conditioned component of nicotine sensitization...
  31. ncbi Evaluation "in-car" countermeasures to sleepiness: cold air and radio
    L A Reyner
    Sleep Research Laboratory, Loughborough University, UK
    Sleep 21:46-50. 1998
    ....
  32. ncbi Enhancement of sensitivity in photoreceptors of the honey been drone by light and by Ca2+
    B Walz
    , , FRG
    J Comp Physiol A 170:605-13. 1992
    ..One possible site of action for this positive and negative feedback control of cell sensitivity by Ca2+ is the endoplasmic reticulum...
  33. ncbi Post-session intra-perifornical region quinpirole infusions retard the consolidation of an appetitive differential conditioning task
    S L Morutto
    Department of Psychology, University of York, Heslington, UK
    Behav Pharmacol 10:113-8. 1999
    ..The present data extends previous findings, suggesting that the level of activation of dopamine receptors in the vicinity of the PFH significantly influences the consolidation of appetitive Pavlovian associations...
  34. ncbi Multiresidue analysis of pesticides using new laminar extraction disks and liquid chromatography and application to the French priority list
    V Pichon
    Laboratoire Environnement et Chimie Analytique (URA CNRS 437, , France
    J Chromatogr A 795:83-92. 1998
    ..The two procedures described in this work allow the handling of any compounds having a water-octanol constant, log Kow, in the range 1-6...
  35. ncbi Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: importance of pretransplant disease burden
    Erica D Warlick
    Blood and Marrow Transplant Program, Departments of Medicine and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 15:30-8. 2009
    ....
  36. ncbi Matrix solid-phase dispersion extraction and high-performance liquid chromatographic determination of residual sulfonamides in chicken
    K Kishida
    Graduate School of Human Life Science, Osaka City University, Japan
    J Chromatogr A 937:49-55. 2001
    ..Average recoveries were greater than 87.6% with relative standard deviations between 0.5 and 8.6%. The total time and amount of solvent required for the analysis of one sample were <1.5 h and <12 ml, respectively...
  37. ncbi Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine
    C J Harmer
    Department of Psychology, University of York, Heslington, UK
    Behav Pharmacol 9:299-308. 1998
    ..These data are discussed in light of possible changes in mesoamygdaloid dopamine functioning...
  38. pmc Two distinct modulatory effects on calcium channels in adult rat sensory neurons
    A Formenti
    Institute of Human Physiology II, University of Milan, Italy
    Biophys J 64:1029-37. 1993
    ..GTP-'y-S (100 ,uM) intracellularly perfused mimicked both the modulatory effects. The two modulations may have different functions in processing nociceptive inputs...
  39. ncbi Amphetamine-induced disruption of latent inhibition depends on the nature of the stimulus
    I Weiner
    Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
    Behav Pharmacol 8:442-57. 1997
    ..The effects of amphetamine on LI were not related to its effects on behavioural suppression after footshock, or on activity...
  40. pmc Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity
    M A Rizzo
    Department of Neurology, Yale University School of Medicine, New Haven 06510
    J Neurophysiol 72:2796-815. 1994
    ..abstract truncated at 400 words)..
  41. ncbi Early bond strength of two resin cements to Y-TZP ceramic using MPS or MPS/4-META silanes
    Mutlu Ozcan
    Dental Materials Unit, Center for Dental and Oral Medicine Clinic for Fixed and Removable Prosthodontics and Dental Materials Science, University of Zurich, Plattenstrasse 11, CH 8032, Zurich, Switzerland
    Odontology 99:62-7. 2011
    ..Use of chairside silica coating and silanization to condition the zirconia surface improved adhesion compared with the manufacturers' cementation protocols for SuperBond and Panavia F 2.0 resin cements...
  42. pmc Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions
    B Everill
    Department of Neurology, Yale University School of Medicine, New Haven 06510, USA
    J Neurophysiol 79:1814-24. 1998
    ....
  43. ncbi Vibration exposure and conditioning lesion effect in nerves: an experimental study in rats
    L B Dahlin
    Department of Hand Surgery, Lund University, , Sweden
    J Hand Surg Am 17:858-61. 1992
    ..By inducing such a conditioning lesion to nerve tissue, vibration represents a trauma corresponding to a crush lesion or transection of the nerve...
  44. ncbi Olfactory and behavioral response thresholds to odors of diseased blood differ between hygienic and non-hygienic honey bees (Apis mellifera L.)
    R Masterman
    Department of Entomology, University of Minnesota, Saint Paul 55108, USA
    J Comp Physiol A 187:441-52. 2001
    ..Our results provide an example of how physiological and behavioral differences between the hygienic and non-hygienic honey bee lines, operating at the level of the individual, could produce colony-specific behavioral phenotypes...
  45. ncbi Smoking expectancy mediates the conditioned responses to arbitrary smoking cues
    M Field
    Laboratory of Experimental Psychology, University of Sussex, Brighton, UK
    Behav Pharmacol 12:183-94. 2001
    ..In addition, these data suggest that craving CRs can be eliminated, whereas compensatory CRs can be facilitated, when cigarette expectancy is removed with instructions...
  46. ncbi Morphine sex-dependently induced place conditioning in adult Wistar rats
    Manizheh Karami
    Department of Biology, Shahed University, Tehran, Iran
    Eur J Pharmacol 582:78-87. 2008
    ..The effect of the antagonist preinjections on body-weight was also observed in males. Present results indicate sex-differences both in reinforcing and locomotor activity effects of morphine in Wistar rats...
  47. ncbi Physiological and subjective responses in the elderly when using floor heating and air conditioning systems
    Nobuko Hashiguchi
    Department of Ergonoics, Faculty of Design, Kyushu University, 4 9 1 Shio baru, Minami Ku, Fukuoka 815 8540, Japan
    J Physiol Anthropol Appl Human Sci 23:205-13. 2004
    ..Moreover, it is particularly important for elderly people to avoid a decrease in peripheral skin temperature, and maintain awareness of the warmth of peripheral areas, such as the leg, in order to ensure thermal comfort...
  48. ncbi Memory impairment induced by cholinergic antagonists injected into the mushroom bodies of the honeybee
    V C Lozano
    Laboratoire Neurobiologie de l Insecte EA 3037, , France
    J Comp Physiol A 187:249-54. 2001
    ..They suggest that the role of the brain structures in these processes is sequential. Mushroom body calyces involved in the associative process of olfactory learning could be relayed by the alpha-lobes for information retrieval...
  49. ncbi Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning
    Søren Lykke Petersen
    Lymphocyte Research Laboratory, Department of Hematology, Rigshospitalet, Copenhagen, Denmark
    Dan Med Bull 54:112-39. 2007
    ..In addition, it is important to continue to elucidate the immunologic mechanisms that are responsible for GVHD and the GVT effect...
  50. ncbi The effects of aerobic exercise on psychological adjustment: a randomized study of sedentary obese women attempting weight loss
    B Stetson
    Department of Psychology, Illinois Institute of Technology, Chicago 60616
    Women Health 19:1-14. 1992
    ..Future studies utilizing longer periods of aerobic exercise training, larger sample size, and exercise specific measures are recommended...
  51. ncbi Stretching in the rehabilitation of low-back pain patients
    T M Khalil
    Comprehensive Pain and Rehabilitation Center, University of Miami Medical School, Florida
    Spine (Phila Pa 1976) 17:311-7. 1992
    ..The use of the systematic stretching maneuver enhanced the functional gains of chronic low-back pain patients compared to the control group...
  52. pmc H-reflex up-conditioning encourages recovery of EMG activity and H-reflexes after sciatic nerve transection and repair in rats
    Yi Chen
    Wadsworth Center, Laboratory of Neural Injury and Repair, New York State Department Health and State University of New York at Albany, Albany, New York 12201 0509, USA
    J Neurosci 30:16128-36. 2010
    ..These results suggest that H-reflex up-conditioning may improve functional recovery after nerve injury and repair...
  53. pmc Interhemispheric inhibition of the human motor cortex
    A Ferbert
    MRC Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, London
    J Physiol 453:525-46. 1992
    ..Similarly, H reflexes in relaxed forearm flexor muscles were unaffected by conditioning stimuli to the ipsilateral hemisphere. However, inhibition was observed if the experiment was repeated with the muscles active...
  54. ncbi Operant conditioning of reciprocal inhibition in rat soleus muscle
    Xiang Yang Chen
    Wadsworth Center, Laboratory of Nervous System Disorders, New York State Department of Health and State University of New York, Albany, New York 12201 0509, USA
    J Neurophysiol 96:2144-50. 2006
    ..Final SOL RI and TA H-reflex sizes were significantly correlated. Thus like the SSR and the H-reflex, RI can be operantly conditioned; and conditioning one reflex can affect another reflex as well...
  55. ncbi Perception of pitch by goldfish
    Richard R Fay
    Parmly Hearing Institute, Department of Psychology, Loyola University, Chicago, IL 60626, USA
    Hear Res 205:7-20. 2005
    ....
  56. ncbi Effectiveness of HVAC duct cleaning procedures in improving indoor air quality
    I Ahmad
    Civil and Environmental Engineering Department, Florida International University, Miami, USA
    Environ Monit Assess 72:265-76. 2001
    ..Homes cleaned with the Air Sweep procedure showed the highest degree of reduction in bioaerosol concentration among the three procedures investigated...
  57. ncbi [Diagnosis of humidifier lung--comparison of various serologic procedures]
    X Baur
    ,
    Pneumologie 45:794-8. 1991
    ..Examination of all the 134 serum samples yielded a high correlation between the results of these two non-radioactive methods and those obtained with the protein-A RAST...
  58. ncbi Is seed conditioning essential for Orobanche germination?
    Dina Plakhine
    Department of Plant Pathology and Weed Research, ARO, Newe Ya ar Research Centre, Ramat Yishay, Israel
    Pest Manag Sci 65:492-6. 2009
    ..The aim of this study was to examine whether conditioning is essential for stimulant receptivity...
  59. ncbi Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: a comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists
    M R Guscott
    Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Behav Pharmacol 11:495-504. 2000
    ..Thus, conditioning and testing animals in different environments may provide a more effective means of distinguishing anxiolytic from non-specific drug effects in the rat FPS test...
  60. ncbi Aversive conditioning of periodic spontaneous erection adversely affects sexual behavior and semen in stallions
    Sue M McDonnell
    Equine Behavior Laboratory, University of Pennsylvania School of Veterinary Medicine, New Bolton Center, PA 19348, USA
    Anim Reprod Sci 89:77-92. 2005
    ....
  61. pmc Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilator action, on guinea-pig ventricular cells
    I Kodama
    Department of Circulation, Nagoya University, Japan
    Br J Pharmacol 114:503-9. 1995
    ..From the onset and offset kinetics of the use-dependent block, SD-3212 is located between fast and intermediate kinetic Class-I drugs. From the state-dependence of sodium channel block, SD-3212 belongs to inactivated channel blockers...
  62. ncbi Sulfide enhancement of PMN apoptosis
    M A Mariggio
    Department of Biomedical Sciences and Human Oncology, Faculty of Medicine, University of Bari, Italy
    Immunopharmacol Immunotoxicol 20:399-408. 1998
    ..The sulfide effect is partially prevented by ionomycin and this finding is consistent with the hypothesis of the inhibiting role played by high levels of cytosolic calcium in PMN apoptosis modulating...
  63. ncbi [Simultaneous cephalic migration of a ventriculoperitoneal shunt into the intraventricular and subdural spaces. A case report]
    V R Cerrón-Rojas
    Hospital Universitario Manuel Ascunce Domenech, Camaguey, Cuba
    Rev Neurol 33:437-9. 2001
    ..It probably involves movement of the craniospinal region of the patient which leads to a follow on effect due to an underlying disorder...
  64. ncbi Microchip capillary electrophoresis using on-line chemiluminescence detection
    M Hashimoto
    Department of Chemical Engineering and Materials Science, Faculty of Engineering, Doshisha University, Kyotanabe, Kyoto, Japan
    J Chromatogr A 867:271-9. 2000
    ..The present system had advantages in rapid separation time (within 40 s), small (several 10 pI) and accurate sample injection method using a cross-shaped injector, and simplification and miniaturization of the detection device...
  65. ncbi Operant conditioning of antennal muscle activity in the honey bee (Apis mellifera L.)
    J Erber
    , , Germany
    J Comp Physiol A 186:557-65. 2000
    ..The conditioned changes of the frequency of muscle potentials in the freely moving antenna are directly comparable to the behavioural changes during operant conditioning...
  66. pmc Pavlov's cockroach: classical conditioning of salivation in an insect
    Hidehiro Watanabe
    Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    PLoS ONE 2:e529. 2007
    ..The results provide a useful model system for studying cellular basis of conditioning of salivation in the simpler nervous system of insects...
  67. pmc Post-bone marrow transplant patient management
    C M Poliquin
    Jean Marie Colbert Bone Marrow Transplant Center, University of Connecticut Health Center, Farmington
    Yale J Biol Med 63:495-502. 1990
    ..When specific discharge criteria are met, the BMT patient is discharged from the hospital. Specific follow-up medical care is ongoing for about one year after BMT...
  68. ncbi Auditory frequency discrimination in the squirrel monkey
    A Wienicke
    Neurobiology Department, German Primate Centre, , Germany
    J Comp Physiol A 187:189-95. 2001
    ..Individuals with high auditory thresholds do not necessarily also have high frequency difference thresholds...
  69. ncbi Effect of blood lactate-guided conditioning of horses with exercises of differing durations and intensities on heart rate and biochemical blood variables
    A Lindner
    Arbeitsgruppe Pferd, Julich, Germany
    J Anim Sci 87:3211-7. 2009
    ..05). It is concluded that conditioning with the exercise types used had small effects. This could have been because the exercise stress was too small, but also because the workload was not increased during the CDP...
  70. ncbi The effects of Tai Chi Chuan on postural stability in the elderly: preliminary report
    Y C Lin
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taipei
    Chang Gung Med J 23:197-204. 2000
    ..CONCLUSION: Our data demonstrate that regular TCC practitioners have better postural stability, especially in the more complicated conditions with disturbed visual and somatosensory conditions...
  71. ncbi Haloperidol-induced potentiation of latent inhibition: interaction with parameters of conditioning
    C Ruob
    Laboratory of Behavioural Biology and Functional Toxicology, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland
    Behav Pharmacol 9:245-53. 1998
    ....
  72. ncbi Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW373U86 and SNC 80: 2. Place-preference and brain microdialysis studies in rats
    R Longoni
    Department of Toxicology, University of Cagliari, Italy
    Behav Pharmacol 9:9-14. 1998
    ..The results indicate that stimulation of delta-opioid receptors has incentive properties that might be related to an indirect amplification of post-synaptic dopamine transmission...
  73. ncbi Monitoring of minimal residual disease by quantitative WT1 gene expression following reduced intensity conditioning allogeneic stem cell transplantation in acute myeloid leukemia
    Anna Candoni
    Division of Hematology and Bone Marrow Transplantation, Department of Medical and Morphologic Research, University of Udine, Udine, Italy
    Clin Transplant 25:308-16. 2011
    ..Our data suggest that, in the RIC-SCT setting, the sequential and quantitative analysis of WT1 may be useful as a leukemia marker for monitoring MRD and as a predictor of overt AML cytologic relapse...
  74. ncbi Nonmyeloablative stem cell transplantation and cell therapy for malignant and non-malignant diseases
    I B Resnick
    Department of Bone Marrow Transplantation and Cancer Immunotherapy, Cell Therapy and Transplantation Research Laboratory, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel
    Transpl Immunol 14:207-19. 2005
    ....
  75. ncbi [Pulmonary complications after bone marrow transplantation]
    H Teschler
    Ruhrlandklinik,
    Pneumologie 48:131-9. 1994
    ....
  76. ncbi Reversed discriminatory responses of heart rate during human REM sleep
    K Ikeda
    Laboratory of Clinical Psychophysiology, Faculty of Education, Hokkaido University, Sapporo, Japan
    Sleep 20:942-7. 1997
    ..These facts suggest a difference in information processing during wakefulness and sleep, in particular REM sleep...
  77. ncbi Postpartum pelvic floor conditioning using vaginal cones: not only for prophylaxis against urinary incontinence and descensus
    W Fischer
    , Berlin, Germany
    Int Urogynecol J Pelvic Floor Dysfunct 7:208-14. 1996
    ..Cone training works well as an alternative or complement to conventional postpartum exercises, and may therefore be recommended especially to puerperae who are not capable of holding vaginal cones of 20-70 g 6 weeks after delivery...
  78. pmc Time course for the development of muscle history in lumbar paraspinal muscle spindles arising from changes in vertebral position
    Weiqing Ge
    Palmer Center Chiropractic Research, Neurophysiology, 741 Brady Street, Davenport, IA 52803 5209, USA
    Spine J 8:320-8. 2008
    ..The present study explores a mechanism that can affect the responsiveness of paraspinal muscle spindles in the lumbar spine...
  79. ncbi Basic organization of operant behavior as revealed in Drosophila flight orientation
    R Wolf
    , , FRG
    J Comp Physiol A 169:699-705. 1991
    ..5) Consistent control of a sensory stimulus by a behavior may lead to a more permanent behavioral change (conditioning). In this scheme operant activity (1-4) and operant conditioning (1-5) are distinguished...
  80. pmc Post-repolarization block of cardiac sodium channels by saxitoxin
    J C Makielski
    Cardiac Electrophysiology Laboratories, University of Chicago, Illinois 60637
    Biophys J 65:790-8. 1993
    ..2 s-1 (KD = 12 nM). These results and the proposed model suggest a novel variation on phasic block mechanisms and suggest a long-lived transient Na+ channel conformation during recovery...
  81. ncbi Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats
    Stephen Maren
    Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Eur J Neurosci 18:3080-8. 2003
    ..Forms of synaptic plasticity that depend on protein synthesis, such as long-term potentiation, are likely candidates for the encoding and long-term storage of fear memories in the amygdala...
  82. ncbi Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat
    M Dahhaoui
    Laboratoire de Neurophysiologie Sensorielle, , Mont Saint Aignan, France
    J Comp Physiol A 171:657-64. 1992
    ..The effects of the inferior olivary complex lesion are obviously different according to the task to be learnt, suggesting that these two tasks do not require the integrity of the same nervous structures...
  83. ncbi [Efficacy and toxicity of intravenous busulfan-based conditioning before allogeneic peripheral blood stem cell transplantation for leukemia]
    Xiu zhen Tong
    Department of Hematology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080, PR China
    Ai Zheng 26:914-8. 2007
    ..This study was to analyze the efficacy and toxicity of intravenous Bu and cyclophosphamide (Cy) conditioning before allogeneic peripheral blood stem cell transplantation (allo-PBSCT) for leukemia...
  84. pmc The cerebellum in maintenance of a motor skill: a hierarchy of brain and spinal cord plasticity underlies H-reflex conditioning
    Jonathan R Wolpaw
    Laboratory of Nervous System Disorders Wadsworth Center, New York State Department of Health and State University of New York at Albany, Albany, New York 12201 0509, USA
    Learn Mem 13:208-15. 2006
    ..Thus, H-reflex conditioning seems to depend on a hierarchy of brain and spinal cord plasticity to which the cerebellum makes an essential contribution...
  85. ncbi Corticospinal tract transection prevents operantly conditioned H-reflex increase in rats
    Xiang Yang Chen
    Laboratory of Nervous System Disorders, Wadsworth Center, New York State Department of Health and State University of New York, PO Box 509, Albany, New York 12201 0509, USA
    Exp Brain Res 144:88-94. 2002
    ....
  86. pmc Legionella species colonization of water distribution systems, pools and air conditioning systems in cruise ships and ferries
    Georgia Goutziana
    Department of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece
    BMC Public Health 8:390. 2008
    ..colonization associated with ship water systems and water characteristics...
  87. ncbi The effects of sound conditioning on gentamicin-induced vestibulocochlear toxicity in gerbils
    Amar C Suryadevara
    Department of Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, New York, USA
    Laryngoscope 119:1166-70. 2009
    ..The objective of this study is to determine whether sound conditioning provides protection against gentamicin in the cochlear and/or vestibular system...
  88. ncbi Latent inhibition and conditioning in rat strains which show differential prepulse inhibition
    L H Conti
    Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    Behav Genet 31:325-33. 2001
    ..These results suggest that BN rats show deficient LI as well as PPI and display poor associative learning, a trait also reported in schizophrenia...
  89. ncbi Attenuation of cerebral oxygen toxicity by sound conditioning
    Avi Shupak
    Israel Naval Medical Institute, Haifa, Israel
    Otol Neurotol 25:186-92. 2004
    ..Sound conditioning might reduce cerebral oxygen toxicity...
  90. ncbi Place aversion induced by blockade of mu or activation of kappa opioid receptors in the dorsal periaqueductal gray matter
    A B Sante
    , FFCLRP, , SP, Brazil
    Behav Pharmacol 11:583-9. 2000
    ..These findings suggest that blockade of mu opioid receptors or activation of kappa opioid receptors in the DPAG may produce conditioned place aversion...
  91. ncbi Incidence of Viral and fungal infections following busulfan-based reduced-intensity versus myeloablative conditioning in pediatric allogeneic stem cell transplantation recipients
    Prakash Satwani
    Department of Pediatrics, Morgan Stanley Children s Hospital of New York Presbyterian, Columbia University, New York, New York 10032, USA
    Biol Blood Marrow Transplant 15:1587-95. 2009
    ..4-210.8; P=< .01). Overall infection-related mortality was only 1.1% (1/86) for SVIs and 2.3% (2/86) for IFIs. Our data indicate that RIC allo-SCT does not carry a lower risk of SVIs and IFIs than MAC allo-SCT in pediatric recipients...
  92. ncbi Youth resistance training: updated position statement paper from the national strength and conditioning association
    Avery D Faigenbaum
    Department of Health and Exercise Science, The College of New Jersey, Ewing, 08628, USA
    J Strength Cond Res 23:S60-79. 2009
    ..This article builds on previous recommendations from the NSCA and should serve as the prevailing statement regarding youth resistance training. It is the current position of the NSCA that:..
  93. ncbi Sensitization to apomorphine in pigeons is due to conditioning, subject to generalization but resistant to extinction
    A M Godoy
    Allgemeine Psychologie, , Germany
    Behav Pharmacol 10:367-78. 1999
    ..These results are related to findings and arguments concerning the sensitization to psychostimulant drugs in mammals...
  94. ncbi Immediate effects of thixotropy conditioning of inspiratory muscles on chest-wall volume in chronic obstructive pulmonary disease
    Masahiko Izumizaki
    Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    Respir Care 51:750-7. 2006
    ..Thixotropy is a passive property of the skeletal muscle that depends on the muscle's immediate history of contraction and length change. Inspiratory-muscle thixotropy affects the end-expiratory position of the rib cage in normal subjects...
  95. ncbi Classical conditioning of autonomic fear responses is independent of contingency awareness
    Douglas H Schultz
    Department of Psychology, University of Wisconsin Milwaukee, PO Box 413, Milwaukee, WI 53211, USA
    J Exp Psychol Anim Behav Process 36:495-500. 2010
    ..These observations support a dual process interpretation of classical conditioning whereby conditioning on an implicit level can occur without explicit knowledge about the contingencies...
  96. ncbi Spinal modulation of the induction of central sensitization
    R J Traub
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Brain Res 778:34-42. 1997
    ....
  97. pmc Neonatal corticosterone administration impairs adult eyeblink conditioning and decreases glucocorticoid receptor expression in the cerebellar interpositus nucleus
    A A Wilber
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive West, Lethbridge, AB, Canada T1K 3M4
    Neuroscience 177:56-65. 2011
    ..This suggests an inverted U-shaped relationship may exist between both neonatal corticosterone levels and adult GR expression in the interpositus nucleus, and adult GR expression in the interpositus and eyeblink conditioning...
  98. ncbi A comparison between low intensity and reduced intensity conditioning in allogeneic hematopoietic stem cell transplantation for solid tumors
    Reka Conrad
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska University Hospital Huddinge F79, SE 141 86 Stockholm, Sweden
    Haematologica 93:265-72. 2008
    ..We performed a non-randomized study comparing low intensity conditioning with reduced intensity conditioning after stem cell transplantation to demonstrate the graft-versus-tumor effect...
  99. ncbi Stem cell transplantation using non-myeloablative conditioning regimen with fludarabine for hematological malignancies
    Kenji Tajika
    Department of Pathophysiological Management Medical Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:254-9. 2010
    ..3%. We concluded that stem cell transplantation using a non-myeloablative conditioning regimen with Flu was a useful therapeutic approach for patients with hematological malignancies...
  100. ncbi Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memory
    Emilio Fernandez Espejo
    Departamento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Neuropsychopharmacology 28:490-8. 2003
    ....
  101. ncbi L-type voltage-gated calcium channels are involved in the in vivo and in vitro expression of fear conditioning
    Patricia Shinnick-Gallagher
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    Ann N Y Acad Sci 985:135-49. 2003
    ..These findings suggest that L-type calcium channels play a role in the amygdala in cued fear conditioning and have important implications in the treatment of anxiety and in emotional learning and plasticity...

Research Grants71

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. THE ROLE OF ACETYLATION IN MITOCHONDRIAL FUNCTION
    Gary Cecchini; Fiscal Year: 2013
    ..Using the SIRT3 KO mouse model, it will be determined if the properties of cardiac tissue such as pre- and post-conditioning are altered by acetylation/deacetylation of proteins. ..
  3. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..As a result there will be multiple repercussions to their defects or failures. It can be anticipated, therefore, that our research will have consequences outside its field of muscle and exercise. ..
  4. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..Experiments are proposed in animal models to test the activity of the compound and if successful the long-term goal of this work is to take this compound in human clinical trials for the treatment of GVHD. ..
  5. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..Through these experiences, Dr. Coghill will obtain the skills necessary to transition to an independent, NIH funded laboratory investigator. ..
  6. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..This information will be important since the primary goal of our genetic-based investigations is to identify susceptible groups for targeted therapeutic interventions. ..
  7. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..Health maintenance and prevention of further disablement and chronic illness is a high priority for VHA. ..
  8. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
    ..This proposal examines new treatment approaches using pharmacological and behavioral treatments to extinguish cue reactivity in an animal model. Such approaches can inform future clinical trials for opiate abusing veterans. ..
  9. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..If the studies outlined in this application are successful, these pre-clinical data will pave the way for approval of iPSC-based clinical trials for not only other forms of EB, but also other inherited skin disorders. ..
  10. Pathogenesis of Postoperative Cognitive Dysfunction
    Zhongcong Xie; Fiscal Year: 2013
    ..This proposal aims to investigate an understudied topic in an innovative system by testing novel hypotheses. Our efforts would ultimately lead to safer surgical care and better post-operative outcomes for senior patients. ..
  11. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    ..The development of hematopoietic-specific conditioning agents should provide a less toxic alternative to current regimens and, thus, has major implications for patients receiving HSCT for the treatment of hematological diseases. ..
  12. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2013
    ..We therefore anticipate rapid translation of the optimized promising pretargeted RIT into our clinical RIT HCT program for AML and MDS. ..
  13. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..This research will enhance our understanding of the neurobiology of traumatic memory processing and aid in the development of therapeutic treatments for PTSD. ..
  14. Double Humanization of Liver and Blood in Mice
    ELIZABETH MARIE WILSON; Fiscal Year: 2012
    ....
  15. Low level exposure to PBDEs: testing the hormetic and epigenetic hypotheses
    Lucio G Costa; Fiscal Year: 2013
    ..Altogether, results from this R21 proposal will provide the basis for further in vivo studies to be carried out with lo doses PBDEs. ..
  16. Novel therapies for Fanconi anemia
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ....
  17. IL-22 in epithelial regeneration after allogeneic transplant
    Alan Hanash; Fiscal Year: 2013
    ..In addition, the career development goal of this project is to help Dr. Hanash transition into an independent investigator with his own laboratory and R01 funding. ..
  18. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ....
  19. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ....
  20. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..elegans. The identification of these molecules will help in the development of new therapies for heart attack and stroke. ..
  21. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    ..Therefore, we expect that these preclinical studies have a high likelihood to improve prophylaxis and treatment of intestinal GVHD as well as overall outcome in allo BMT patients. ..
  22. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..These studies would allow us to compare the different and overlapping targets of these two paralogous HATs, and help in the understanding of activity-dependent gene activation in the neuron during memory storage. ..
  23. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..making incremental but sustainable changes in behavior, setting weekly behavioral goals, self-monitoring of progress towards goals, identification of barriers, etc., and will be incorporated into weekly group meetings. ..
  24. Human VGF Polymorphisms and Depression
    Stephen R Salton; Fiscal Year: 2010
    ....
  25. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ....
  26. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ....
  27. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..To test for donor-specific tolerance and immunocompetence to donor third party allo-antigens, donor skin grafts will be placed on the recipient. ..
  28. Genome-wide Association Study: Fetal Hemoglobin Phenotypes in Sickle Cell Disease
    Betty Pace; Fiscal Year: 2009
    ..abstract_text> ..
  29. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..With the prospect of identifying new molecular targets, and the future application of this model to screen compounds for medications development, this project has a tremendous potential impact for the treatment of human drug addiction. ..
  30. Improving Air Quality for Laboratory Animal Research
    Sharron S Quisenberry; Fiscal Year: 2010
    ..A Project Liaison Officer will assist with communications and coordination among the key scientists and other Key Personnel. ..
  31. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2012
    ..These studies could prove to be especially useful in the future evaluation of putative pharmacotherapies to reduce craving and in the design of behavioral interventions (e.g., cue-exposure therapy) to decrease ethanol-seeking behavior. ..
  32. Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2013
    ..Further, these studies will accelerate discovery of new therapeutic targets or strategies that could substantially improve the cardioprotective efficacy of GLP-1 based therapies in patients with obesity-related cardiovascular disease. ..
  33. Chronic kidney disease in survivors of hematopoietic cell transplant
    Sangeeta Hingorani; Fiscal Year: 2012
    ..abstract_text> ..
  34. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ....
  35. Brain tumors with regulatory T-cells treated with EGFRvIII-specific T-cells
    John H Sampson; Fiscal Year: 2013
    ....
  36. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    ....
  37. Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environm
    Hector L Aguila; Fiscal Year: 2010
    ..In addition, these techniques can be adapted for developing novel venues to control the metastasis and establishment of tumors into bone. ..
  38. Functional impact of dendritic cell phenotype in a mouse model of myositis
    Dana P Ascherman; Fiscal Year: 2010
    ..The latter objective is relevant to the treatment of multiple autoimmune diseases for which global immunosuppression is the only therapeutic option. ..
  39. Impaired hippocampal function as a risk factor for Post-Traumatic Stress Disorder
    Almira Vazdarjanova; Fiscal Year: 2013
    ..Findings from Aim 3 will suggest investigating treatments to confer resilience that have a high compliance rate, as they will be low-stress. ..
  40. Hematopoietic gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2013
    ....
  41. Metabolic &Developmental Aspects of Intellectual Disability
    Mary C McKenna; Fiscal Year: 2013
    ..abstract_text> ..
  42. Role of Protective and Pathogenic B cells in Modulating Pediatric Severe Malaria
    Tom Were; Fiscal Year: 2013
    ..Since this proposal will perform investigations in extensively phenotyped cohorts of children, we will maximize our ability to successfully identify those B cell subsets tha influence the development of SMA. ..
  43. Radioimmunotherapy for Multiple Myeloma
    Damian J Green; Fiscal Year: 2013
    ..This project is designed to develop a new approach, already proven effective for patients with leukemia and lymphoma, that directly targets multiple myeloma cells with small radioactive particles to selectively destroy them. ..
  44. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2013
    ..abstract_text> ..
  45. Role of LXR and ABCA1 in Abeta Aggregation and Toxicity
    NICHOLAS FRANCIS FITZ; Fiscal Year: 2012
    ..Better understanding the role of cholesterol metabolism in AD pathology will help develop new routes of treatment to slow disease progression. ..
  46. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
    ....
  47. Lentivirus-based positive/negative selection in minimally ablative transplants
    KARIN L GAENSLER; Fiscal Year: 2013
    ....
  48. Insulin Sensitivity using Aerobic Interval Conditioning (ISAIC)
    Conrad P Earnest; Fiscal Year: 2010
    ..abstract_text> ..
  49. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills-Karp; Fiscal Year: 2013
    ..List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Wills-Karp, Marsha Wildc7 CCHMC PI Finkelman, Fred frefin CCHMC Co-Investigator ..
  50. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..The work is relevant to human anxiety disorders and promises to elucidate critical events in the formation and elimination of fear and anxiety. ..
  51. Aging Oxidative Stress and Microglia
    Paula C Bickford; Fiscal Year: 2013
    ..This will inform us as to critical pathways to target for the development of new interventions to improve cognitive aging. ..
  52. Screening New Therapeutics for the Treatment of Post Traumatic Stress Disorder
    NEAL GORDON SIMON; Fiscal Year: 2011
    ..This proposal will use a unique predatory fear conditioning paradigm as a preclinical model to test the feasibility of using novel V1a antagonists as a potential new pharmacotherapy for PTSD. ..
  53. Is Maternal Iron Status a Risk Factor in Fetal Alcohol Syndrome?
    Susan M Smith; Fiscal Year: 2010
    ..This work tests the hypothesis that nutritional factors may exacerbate alcohol's effects upon the fetus or infant. It addresses the concept that nutritional intervention might reduce FASD incidence for women at risk. ..
  54. EMBRYONIC STEM CELLS INDUCE SPECIFIC GRAFT TOLERANCE
    Nicholas Zavazava; Fiscal Year: 2012
    ..Achievement of these goals will establish ESC as a new source of hematopoietic cells that can be used for tolerance induction without harsh immunosuppression of the recipient. ..
  55. Redefining Human Myocardial Biology
    Annarosa Leri; Fiscal Year: 2013
    ..Stem cell therapy may be prospected as a novel therapeutic strategy for the failing heart. ..
  56. Extinction is mediated by the infralimbic cortex and protein kinase C epsilon
    Philip M Newton; Fiscal Year: 2010
    ..In the current proposal, we will lay the foundations for proposals to determine the brain regions in which PKC5 acts to control addictive behavior. ..
  57. VGF function in depression and antidepressant treatment
    Stephen R Salton; Fiscal Year: 2013
    ....
  58. Mechanisms of Stress-Enhanced Aversive Conditioning
    Jelena Radulovic; Fiscal Year: 2013
    ..Targeting selected protein kinases among a multitude of receptor-activated pathways will increase the specificity while minimizing side effects of emerging treatments for fear symptoms in PTSD and ASD. ..
  59. Controlling Th2 immunity by tuning CXCL13 dependent DC migration in lymph nodes
    Frances E Lund; Fiscal Year: 2013
    ....
  60. Cell Therapies for Cooley's Anemia
    Thomas M Ryan; Fiscal Year: 2013
    ..abstract_text> ..
  61. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ....
  62. Targeted Improvement in Stem Cell Therapy for Leukemia and Bone Marrow Failure Sy
    Qishen Pang; Fiscal Year: 2013
    ..The goal of the project is to develop a novel preclinical regimen to improve BMT therapy for leukemia and BM failure diseases, clinical settings in which intensive preconditioning and scarce stem cell numbers critically limit success. ..
  63. CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATION
    Barry Dworkin; Fiscal Year: 2006
    ....
  64. AIR CONDITIONING BY THE TRACHEA--STIMULI AND MECHANISMS
    Mark Deffebach; Fiscal Year: 1993
    ..From these studies a clearer picture of the effects of dry air, and its component stimuli, will emerge. This may improve our understanding of asthma, and lead to improvements in our therapy of exercise induced asthma...
  65. Amygdalar Modulation of Fear-Conditioned Changes in REM Sleep
    ADRIAN MORRISON; Fiscal Year: 2009
    ..It is very important to investigate the serotonergic modulation of CFC in animals because drugs that influence 5-HT function have widespread acceptance for treating PTSD yet little is known about their actions in related animal models. ..
  66. Plasticity in deep cerebellar nuclei as a function of classical conditioning
    Bernard G Schreurs; Fiscal Year: 2010
    ..By identifying these changes, the proposed work has the potential to help understand the pathogenesis of failures in learning and memory and to develop intervention strategies for those failures. ..
  67. Glucocorticoid mechanisms of neonatal separation effects on adult learning
    Aaron A Wilber; Fiscal Year: 2009
    ..S. citizens are affected by mental disorders every year. Understanding the mental health consequences of intentional (e.g., abuse and neglect) and unintentional (e.g., NICU) perinatal stressors is crucial to preventative treatment. ..
  68. Optimizing Nonmyeloablative Stem Cell Transplantation
    Marco Mielcarek; Fiscal Year: 2007
    ..abstract_text> ..
  69. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    Richard E Zigmond; Fiscal Year: 2010
    ..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
  70. Role of Orphan Nuclear Receptor Nurr1 in Fear Conditioning
    Jonathan Ploski; Fiscal Year: 2007
    ..The studies outlined in this proposal will lay the groundwork for identifying novel targets of CREB-mediated gene expression in the LA and for examining their role in fear memory formation. [unreadable] [unreadable] [unreadable]..
  71. Complete Fear Conditioning Suite for Rats and Mice
    Michael S Fanselow; Fiscal Year: 2010
    ..The use of such a model will allow for a more defined understanding of the neural, genetic, behavioral components underlying human anxiety disorders. Such knowledge would allow for the developments of better treatments. ..