Genomes and Genes
Summary: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Publications404 found, 100 shown here
- The inflammasomesKate Schroder
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Cell 140:821-32. 2010..Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy...
- Myeloid-derived suppressor cells as regulators of the immune systemDmitry I Gabrilovich
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
Nat Rev Immunol 9:162-74. 2009Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses...
- Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigmSubhra K Biswas
Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
Nat Immunol 11:889-96. 2010..The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function...
- Autophagy in immunity and inflammationBeth Levine
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
Nature 469:323-35. 2011..Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect ..
- Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Hepatology 41:1313-21. 2005..comprised 14 histological features, 4 of which were evaluated semi-quantitatively: steatosis (0-3), lobular inflammation (0-2), hepatocellular ballooning (0-2), and fibrosis (0-4)...
- Inflammation and cancer: back to Virchow?F Balkwill
ICRF Translational Oncology Laboratory, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
Lancet 357:539-45. 2001The response of the body to a cancer is not a unique mechanism but has many parallels with inflammation and wound healing...
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
- Exploring the full spectrum of macrophage activationDavid M Mosser
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
Nat Rev Immunol 8:958-69. 2008..We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations...
- Pattern recognition receptors and inflammationOsamu Takeuchi
WPI Immunology Frontier Research Center, Osaka University, Suita, Japan
Cell 140:805-20. 2010..However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. In this Review, we discuss the role of PRRs, their signaling pathways, and how they control inflammatory responses...
- A role for mitochondria in NLRP3 inflammasome activationRongbin Zhou
Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 469:221-5. 2011..This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases...
- Macrophage plasticity and polarization: in vivo veritasAntonio Sica
Istituto Clinico Humanitas IRCCS, Rozzano, Italy
J Clin Invest 122:787-95. 2012..g., ontogenesis and pregnancy) and in pathology (allergic and chronic inflammation, tissue repair, infection, and cancer)...
- Origin and physiological roles of inflammationRuslan Medzhitov
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
Nature 454:428-35. 2008b>Inflammation underlies a wide variety of physiological and pathological processes. Although the pathological aspects of many types of inflammation are well appreciated, their physiological functions are mostly unknown...
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Getting to the site of inflammation: the leukocyte adhesion cascade updatedKlaus Ley
Robert M Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Nat Rev Immunol 7:678-89. 2007..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade.
- Nuclear factor-kappaB in cancer development and progressionMichael Karin
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
Nature 441:431-6. 2006..NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist ..
- Inflammation, stress, and diabetesKathryn E Wellen
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Invest 115:1111-9. 2005..It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the ..
- Inflammation and metabolic disordersGokhan S Hotamisligil
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Nature 444:860-7. 2006..Collectively, these diseases constitute the greatest current threat to global human health and welfare...
- Prostaglandins and leukotrienes: advances in eicosanoid biologyC D Funk
Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 294:1871-5. 2001..from phospholipase-released arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. They are generated by cyclooxygenase isozymes and 5-lipoxygenase, respectively, and their biosynthesis and ..
- From inflammation to sickness and depression: when the immune system subjugates the brainRobert Dantzer
Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
Nat Rev Neurosci 9:46-56. 2008..These phenomena might account for the increased prevalence of clinical depression in physically ill people. Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like ..
- Inflammation meets cancer, with NF-κB as the matchmakerYinon Ben-Neriah
Lautenberg Center for Immunology, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem, Israel
Nat Immunol 12:715-23. 2011b>Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer...
- An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformationDimitrios Iliopoulos
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Cell 139:693-706. 2009b>Inflammation is linked clinically and epidemiologically to cancer, and NF-kappaB appears to play a causative role, but the mechanisms are poorly understood...
- Sterile inflammation: sensing and reacting to damageGrace Y Chen
Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Michigan 48109, USA
Nat Rev Immunol 10:826-37. 2010..The sterile inflammation that ensues either resolves the initial insult or leads to disease...
- The cellular and signaling networks linking the immune system and metabolism in diseaseOlivia Osborn
Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, California, USA
Nat Med 18:363-74. 2012..Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes and cardiovascular disease, and a number of studies have ..
- NF-κB and the link between inflammation and cancerJoseph A DiDonato
Cleveland Clinic Foundation, Department of Cell Biology, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, USA
Immunol Rev 246:379-400. 2012..all malignancies, NF-κB acts in a cell type-specific manner: activating survival genes within cancer cells and inflammation-promoting genes in components of the tumor microenvironment...
- Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instabilityFrancesco Colotta
Nerviano Medical Sciences, Nerviano, Milan, Italy
Carcinogenesis 30:1073-81. 2009..component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer...
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsPeter Duewell
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 464:1357-61. 2010The inflammatory nature of atherosclerosis is well established but the agent(s) that incite inflammation in the artery wall remain largely unknown...
- Inflammation and atherosclerosisPeter Libby
Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 105:1135-43. 2002..Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic ..
- Biologic basis for interleukin-1 in diseaseC A Dinarello
Department of Medicine, Tufts University, Boston, MA USA
Blood 87:2095-147. 1996..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
- The nature of small-airway obstruction in chronic obstructive pulmonary diseaseJames C Hogg
University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
N Engl J Med 350:2645-53. 2004..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
- The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaFabio Martinon
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Mol Cell 10:417-26. 2002..Thus, the inflammasome constitutes an important arm of the innate immunity...
- Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvantsStephanie C Eisenbarth
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 453:1122-6. 2008..This is likely to affect how we design effective, but safe, adjuvants in the future...
- Interferon-gamma: an overview of signals, mechanisms and functionsKate Schroder
Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
J Leukoc Biol 75:163-89. 2004..In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-alpha, interleukin-4, type I IFNs, and lipopolysaccharide are discussed...
- Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 8:349-61. 2008Active resolution of acute inflammation is a previously unrecognized interface between innate and adaptive immunity...
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCVeit Hornung
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 458:514-8. 2009..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
- Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFV A Fadok
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Clin Invest 101:890-8. 1998..phagocytic cells, a critical process in tissue remodeling, regulation of the immune response, or resolution of inflammation. Phagocytosis of apoptotic cells by macrophages has been suggested to be a quiet process that does not lead to ..
- Type 2 diabetes as an inflammatory diseaseMarc Y Donath
Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, CH 4031 Basel, Switzerland
Nat Rev Immunol 11:98-107. 2011..Together, these changes suggest that inflammation participates in the pathogenesis of T2D...
- Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingKamran Ghoreschi
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 467:967-71. 2010..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
- Neutrophil recruitment and function in health and inflammationElzbieta Kolaczkowska
Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, Alberta T2N 4N1, Canada
Nat Rev Immunol 13:159-75. 2013..Although neutrophils are undoubtedly major effectors of acute inflammation, several lines of evidence indicate that they also contribute to chronic inflammatory conditions and adaptive ..
- The inflammasomes: guardians of the bodyFabio Martinon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Annu Rev Immunol 27:229-65. 2009..In this review, we discuss the role of NLRs, and in particular the inflammasomes, in the recognition of microbial and danger components and the role they play in health and disease...
- Release of chromatin protein HMGB1 by necrotic cells triggers inflammationPaola Scaffidi
DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
Nature 418:191-5. 2002..binds with high affinity to RAGE (the receptor for advanced glycation end products) and is a potent mediator of inflammation. HMGB1 is secreted by activated monocytes and macrophages, and is passively released by necrotic or damaged ..
- The immunopathogenesis of sepsisJonathan Cohen
Brighton and Sussex Medical School, Westlain House, Falmer, UK
Nature 420:885-91. 2002..As a result, much has been learnt of the basic principles governing bacterial-host interactions, and new opportunities for therapeutic intervention have been revealed...
- Adipokines: inflammation and the pleiotropic role of white adipose tissuePaul Trayhurn
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
Br J Nutr 92:347-55. 2004..In addition, there is a growing list of adipokines involved in inflammation (TNFalpha, IL-1beta, IL-6, IL-8, IL-10, transforming growth factor-beta, nerve growth factor) and the acute-..
- Inflammation in atherosclerosisPeter Libby
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 420:868-74. 2002..The new appreciation of the role of inflammation in atherosclerosis provides a mechanistic framework for understanding the clinical benefits of lipid-lowering ..
- The NALP3 inflammasome is involved in the innate immune response to amyloid-betaAnnett Halle
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:857-65. 2008..Our findings suggest that activation of the NALP3 inflammasome is important for inflammation and tissue damage in Alzheimer's disease.
- A clinical perspective of IL-1β as the gatekeeper of inflammationCharles A Dinarello
Department of Medicine, University of Colorado, Aurora, CO 80045, USA
Eur J Immunol 41:1203-17. 2011..Therefore, blocking IL-1β resolves inflammation regardless of how the cytokine is released from the cell or how the precursor is cleaved...
- Progress and challenges in translating the biology of atherosclerosisPeter Libby
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 473:317-25. 2011..despite these advances, we still lack definitive evidence to show that processes such as lipoprotein oxidation, inflammation and immunity have a crucial involvement in human atherosclerosis...
- Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationJ M Kyriakis
Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Physiol Rev 81:807-69. 2001..This, despite the fact that the impact of these pathways on the pathology of chronic inflammation, heart disease, stroke, the debilitating effects of diabetes mellitus, and the side effects of cancer therapy, ..
- CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesitySatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Nat Med 15:914-20. 2009b>Inflammation is increasingly regarded as a key process underlying metabolic diseases in obese individuals. In particular, obese adipose tissue shows features characteristic of active local inflammation...
- Resolution of inflammation: the beginning programs the endCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 6:1191-7. 2005Acute inflammation normally resolves by mechanisms that have remained somewhat elusive...
- Gout-associated uric acid crystals activate the NALP3 inflammasomeFabio Martinon
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nature 440:237-41. 2006..released from dying cells, little is known about the molecular mechanisms underlying MSU- or CPPD-induced inflammation. Here we show that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, ..
- Adipocytokines: mediators linking adipose tissue, inflammation and immunityHerbert Tilg
Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Nat Rev Immunol 6:772-83. 2006..are soluble mediators derived mainly from adipocytes (fat cells), in the interaction between adipose tissue, inflammation and immunity...
- Inflammation, atherosclerosis, and coronary artery diseaseGoran K Hansson
Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
N Engl J Med 352:1685-95. 2005
- Immunity, inflammation, and cancerSergei I Grivennikov
Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, 92093, USA
Cell 140:883-99. 2010..b>Inflammation also affects immune surveillance and responses to therapy...
- Mechanisms underlying inflammation in neurodegenerationChristopher K Glass
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, USA
Cell 140:918-34. 2010b>Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis...
- NF-kappaB regulation in the immune systemQiutang Li
The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Immunol 2:725-34. 2002..these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer...
- Inflammatory mechanisms in obesityMargaret F Gregor
Departments of Genetics and Complex Diseases and Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Annu Rev Immunol 29:415-45. 2011..unique features of this metabolic inflammatory state, termed metaflammation and defined as low-grade, chronic inflammation orchestrated by metabolic cells in response to excess nutrients and energy...
- Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in micePatrice D Cani
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
Diabetes 57:1470-81. 2008Diabetes and obesity are characterized by a low-grade inflammation whose molecular origin is unknown...
- Cancer-related inflammationAlberto Mantovani
Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy
Nature 454:436-44. 2008The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs...
- Interleukin-17 family members and inflammationJay K Kolls
Division of Pulmonology, Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA, USA
Immunity 21:467-76. 2004..Increasing evidence shows that IL-17 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer. This places IL-17 family members and their receptors as potential targets for future pharmacotherapy...
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceHaiyan Xu
Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
J Clin Invest 112:1821-30. 2003..population studies and animal research has established correlative as well as causative links between chronic inflammation and insulin resistance. However, the underlying molecular pathways are largely unknown...
- Autophagy in infection, inflammation and immunityVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, North East, Albuquerque, New Mexico 87131, USA
Nat Rev Immunol 13:722-37. 2013..Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome ..
- Inflammation and cancerLisa M Coussens
Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
Nature 420:860-7. 2002Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation...
- Cryopyrin activates the inflammasome in response to toxins and ATPSanjeev Mariathasan
Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 440:228-32. 2006..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
- Innate immune activation through Nalp3 inflammasome sensing of asbestos and silicaCatherine Dostert
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Science 320:674-7. 2008The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer...
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationVeit Hornung
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:847-56. 2008Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure to silica can lead to the development of silicosis, an irreversible, fibrotic pulmonary disease...
- Inflammatory links between obesity and metabolic diseaseCarey N Lumeng
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109 5652, USA
J Clin Invest 121:2111-7. 2011The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity...
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesityJorge Henao-Mejia
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 482:179-85. 2012..Twenty per cent of NAFLD individuals develop chronic hepatic inflammation (non-alcoholic steatohepatitis, NASH) associated with cirrhosis, portal hypertension and hepatocellular ..
- The complexity of NF-κB signaling in inflammation and cancerBastian Hoesel
Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria
Mol Cancer 12:86. 2013The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and progression...
- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimerCameron R Stewart
Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 11:155-61. 2010..identify CD36-TLR4-TLR6 activation as a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation and suggest a new model of TLR heterodimerization triggered by coreceptor signaling events.
- Inflammation and insulin resistanceSteven E Shoelson
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:1793-801. 2006..This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of ..
- Monocyte recruitment during infection and inflammationChao Shi
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Rev Immunol 11:762-74. 2011..During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by local ..
- Inflammation in neurodegenerative diseasesSandra Amor
Department of Pathology, VU University Medical Centre De Boelelaan, Amsterdam, The Netherlands
Immunology 129:154-69. 2010....
- Inflammation and its discontents: the role of cytokines in the pathophysiology of major depressionAndrew H Miller
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 65:732-41. 2009Recognition that inflammation may represent a common mechanism of disease has been extended to include neuropsychiatric disorders including major depression...
- Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxinL V Borovikova
The Picower Institute for Medical Research, Manhasset, New York 11030, USA
Nature 405:458-62. 2000..However, comparatively little is known about the role of efferent vagus nerve signalling in modulating inflammation. Here, we describe a previously unrecognized, parasympathetic anti-inflammatory pathway by which the brain ..
- Inflamm-aging. An evolutionary perspective on immunosenescenceC Franceschi
Department of Experimental Pathology, University of Bologna, Italy
Ann N Y Acad Sci 908:244-54. 2000..In conclusion, the beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental ..
- Immunological and inflammatory functions of the interleukin-1 familyCharles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
Annu Rev Immunol 27:519-50. 2009..in host defense against infection, unlike the TLR family, the IL-1 family also includes members that suppress inflammation, both specifically within the IL-1 family but also nonspecifically for TLR ligands and the innate immune ..
- Macrophages, inflammation, and insulin resistanceJerrold M Olefsky
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
Annu Rev Physiol 72:219-46. 2010..Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for ..
- IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancerMads Gyrd-Hansen
Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen DK2200, Denmark
Nat Rev Cancer 10:561-74. 2010..Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis...
- Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factorNikhil S Joshi
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 27:281-95. 2007..e., IL-12) present during T cell priming. According to the amount of inflammation, a gradient of T-bet was created in which high T-bet expression induced SLECs and low expression promoted MPECs...
- NF-kappaB: a key role in inflammatory diseasesP P Tak
Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
J Clin Invest 107:7-11. 2001
- Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African childrenChristopher A Moxon
Malawi Liverpool Wellcome Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi
Blood 122:842-51. 2013..Because of the pleiotropic nature of EPCR and TM, these data implicate disruption of the endothelial protective properties at vulnerable sites and particularly in the brain, linking coagulation and inflammation with IE sequestration.
- Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeabilityP D Cani
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
Gut 58:1091-103. 2009..Here, we hypothesised that prebiotic modulation of gut microbiota lowers intestinal permeability, by a mechanism involving glucagon-like peptide-2 (GLP-2) thereby improving inflammation and metabolic disorders during obesity and diabetes.
- Nonresolving inflammationCarl Nathan
Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA
Cell 140:871-82. 2010Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosis can provoke inflammation...
- Macrophage activation and polarizationFernando Oneissi Martinez
Istituto Clinico Humanitas, I 20089 Rozzano, Italy
Front Biosci 13:453-61. 2008..Beyond infection M2 polarized macrophages play a role in resolution of inflammation through high endocytic clearance capacities and trophic factor synthesis, accompanied by reduced pro-..
- Thioredoxin-interacting protein links oxidative stress to inflammasome activationRongbin Zhou
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Nat Immunol 11:136-40. 2010..The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1beta in the pathogenesis of type 2 diabetes...
- Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanismMichelle L Block
Neuropharmacology Section, MD F1 01, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
Prog Neurobiol 76:77-98. 2005b>Inflammation, a common denominator among the diverse list of neurodegenerative diseases, has recently been implicated as a critical mechanism responsible for the progressive nature of neurodegeneration...
- The inflammasome NLRs in immunity, inflammation, and associated diseasesBeckley K Davis
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
Annu Rev Immunol 29:707-35. 2011..Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge. This review presents and integrates recent progress in the field...
- Overweight, obesity and cancer: epidemiological evidence and proposed mechanismsEugenia E Calle
American Cancer Society, 1599 Clifton Road, Atlanta, Georgia 30306, USA
Nat Rev Cancer 4:579-91. 2004
- Systemic manifestations and comorbidities of COPDP J Barnes
National Heart and Lung Institute, Imperial College, London, UK
Eur Respir J 33:1165-85. 2009..In addition, as COPD results from inflammation and/or alterations in repair mechanisms, the "spill-over" of inflammatory mediators into the circulation may ..
- Identification of splenic reservoir monocytes and their deployment to inflammatory sitesFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Science 325:612-6. 2009..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation.
- Oxidative stress, inflammation, and cancer: how are they linked?Simone Reuter
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Free Radic Biol Med 49:1603-16. 2010..during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular, neurological,..
- Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesisHerbert Tilg
Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
Hepatology 52:1836-46. 2010Whereas in most cases a fatty liver remains free of inflammation, 10%-20% of patients who have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). Inflammation may precede steatosis in certain instances...
- Adipose tissue remodeling and obesityKai Sun
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8549, USA
J Clin Invest 121:2094-101. 2011....
- Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesAdilson Guilherme
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Rev Mol Cell Biol 9:367-77. 2008....
- C-reactive protein: a critical updateMark B Pepys
Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
J Clin Invest 111:1805-12. 2003
- Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007b>Inflammation is implicated in the progressive nature of neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are poorly understood. A single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p...
- Principles of bioactive lipid signalling: lessons from sphingolipidsYusuf A Hannun
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
Nat Rev Mol Cell Biol 9:139-50. 2008..lyso-sphingomyelin, which have roles in the regulation of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking...
- TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agentsDiana M Bautista
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
Cell 124:1269-82. 2006..Thus, TRPA1 is an important component of the transduction machinery through which environmental irritants and endogenous proalgesic agents depolarize nociceptors to elicit inflammatory pain...
- Gut inflammation provides a respiratory electron acceptor for SalmonellaSebastian E Winter
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
Nature 467:426-9. 2010Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages...
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisBin Zhi Qian
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
Nature 475:222-5. 2011..Our data provide the mechanistic link between these two clinical associations and indicate new therapeutic targets for treating metastatic breast cancer...
- The anti-inflammatory effect of exerciseAnne Marie W Petersen
Dept of Infectious Diseases, Rigshospitalet, Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
J Appl Physiol 98:1154-62. 2005..The latter disorders have been associated with chronic low-grade systemic inflammation reflected by a two- to threefold elevated level of several cytokines...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..for the Treatment of Active Sight-Threatening Uveitis Number: 12-EI-0168 Background: - Uveitis is an eye inflammation that can cause vision loss. It is treated with eye drops, drugs and sometimes surgery...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..for the Treatment of Active Sight-Threatening Uveitis Number: 12-EI-0168 Background: - Uveitis is an eye inflammation that can cause vision loss. It is treated with eye drops, drugs and sometimes surgery...
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..Cytokines secondary to inflammation and exogenous treatment with steroids can cause mood and cognitive changes in these same brain regions...
- Transcription factors regulating sensory gene expression and pain pathwaysEric E Turner; Fiscal Year: 2011..Neuropathic pain results when pain mechanisms, ususally initiated by trauma or inflammation, "take on a life of their own" as diseases of the nervous system, uncoupled from ongoing tissue injury...
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..BCAAs), free fatty acids (FFAs), ketone bodies, triacylglcyerols (TAG), cholesterol, blood pH, and markers of inflammation and oxidative stress in mice fed a high saturated fat diet;(b) determine the molecular mechanisms responsible ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..6/million) and GCTA (20-200/100,000) to the arterial inflammation associated with atherosclerosis and aneurysm formation...
- Mapping for Specialized Domains for FCeRI Signaling &InternalizationBridget S Wilson; Fiscal Year: 2013..analyses will contribute important new insight specifically into the molecular events that initiate allergic inflammation and more generally into the nature and assembly of membrane microdomains controlling signal transduction and ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2011DESCRIPTION (provided by applicant): Chronic gingival inflammation afflicts over half of all American adults and can progress to periodontal disease, eventually resulting in tooth loss...
- ASTHMA AND ALLERGIC DISEASE CENTERThomas A Platts Mills; Fiscal Year: 2010..between physical fitness, obesity, and metabolic syndrome on the one hand, and allergic responses and inflammation on the other...
- Tibor T Glant; Fiscal Year: 2016..3-0.5 % of the human population and causing a debilitating condition. AS starts with inflammation around ligament and tendon attachments (enthesitis) and is frequently associated with inflammation of the ..
- Jill M Wecht; Fiscal Year: 2014..aim will be to determine if hypoxemia stemming from repetitive apneas leads to elevation in markers of vascular inflammation, specifically high sensitivity C-reactive protein and interleukin-6, in individuals with OSA compared to those ..
- Paolo Fanti; Fiscal Year: 2014..and MTh flavonolignans will reduce proteinuria and urinary and systemic manifestations of oxidative stress and inflammation, which are characteristically observed in patients with T2DM and related nephropathy...
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..dysfunction, carotid intimal-medial thickening, and pulmonary hypertension, independently of hemolysis, inflammation, and night-time hypoxia...
- Cory Teuscher; Fiscal Year: 2014DESCRIPTION (provided by applicant): Histamine is a potent mediator of inflammation and regulator of innate and adaptive immune responses, and autoimmune diseases such as experimental allergic encephalomyelitis (EAE), the principal ..
- Role of NGF in inflammatory and proliferative cascades of psoriatic diseaseSiba P Raychaudhuri; Fiscal Year: 2012..A role of neurogenic inflammation in psoriasis is suggested by proliferation of lesional cutaneous nerves, upregulation of neuropeptides, and ..
- Cross-talk Between Coagulation, Inflammation, and ImmunityLawrence L Leung; Fiscal Year: 2013..a new substrate for CPB and providing a novel molecular link between hemostasis/thrombosis and tissue inflammation and immunity. Aim 1. To determine the biology of OPN-R and OPN-L in human glioblastoma (GBM)...
- Carole R Mendelson; Fiscal Year: 2016..of the innate immune system within the lung to protect against invading microorganisms and to modulate inflammation. The studies outlined in this proposal will advance our understanding of the biochemical, genetic and ..
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..and release into the circulation: a) 24 h food deprivation compared to ad libitum feeding and b) acute inflammation compared to healthy rats (peritoneal injection of gram-negative bacteriallipopolysaccharides at non-toxic doses)..
- Autonomic, Endothelial, and Inflammatory Correlates of Sleep DurationMERCEDES RENEE CARNETHON; Fiscal Year: 2012..that could explain these associations such as autonomic nervous system dysfunction, endothelial dysfunction, inflammation, and insulin resistance have been identified in the setting of sleep disordered breathing (SDB), namely sleep ..
- Multi-targeted Countermeasures against Acute and Delayed Effects of OP ExposureJohn A Butera; Fiscal Year: 2013..and clinically for cardiac ischemia, hemorrhagic shock syndrome, stroke, traumatic CNS injury, diabetes, inflammation, and cancer...
- Comprehensive biomarker study to capitalize on existing GWAS in 10K South AsiansDanish Saleheen; Fiscal Year: 2010..renal function (creatinine, cystatin C, ADMA, uric acid, 25(OH)vitamin D, parathyroid hormone);and (4) inflammation and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum amyloid A, MMP-9, E-selectin, P-selectin, ..
- Qinghua Sun; Fiscal Year: 2015..To investigate if air pollution exposure contributes to adiposity and inflammation in adipose tissues that induces insulin resistance and vascular dysfunction, we hypothesize that exposure to ..
- Prevention of Acute Lung Injury by IL-6 activated STAT3Ana Moran; Fiscal Year: 2010..of T/HS that result in ALI, including apoptosis of up to 15% of lung AECs followed by alveolar and interstitial inflammation, and 72% mortality...
- Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of SclerodRobert B Zurier; Fiscal Year: 2012..SSc;scleroderma) is a complex multisystem autoimmune disease of unknown cause associated with early transient inflammation and vascular injury followed by progressive fibrosis affecting skin and internal organs;most frequently ..
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010..studies of transgenic mice and human tissues, we have identified galectin-3 as a key molecule involved in skin inflammation. We have begun to characterize drugs targeting galectin-3 for treatment of eczema...
- Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for EndotoxemiaGARRY JOHN SOUTHAN; Fiscal Year: 2012..that targets the basic mechanisms of septic shock, and has proven effective in experimental models of septic inflammation. We will now test this agent in a series of investigations in order to determine the optimal dose, to confirm ..
- Merrill D Benson; Fiscal Year: 2014..All of these diseases, whether acquired or genetic, cause recurrent inflammation resulting in elevated expression of the acute phase proteins of the serum amyloid A (SAA) family...
- Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver CancerPeter H Gann; Fiscal Year: 2010..Oxidative stress due to chronic inflammation is a dominant force in the progression of chronic liver disease (CLD) and subsequent HCC...
- ANTHONY JOHN KANAI; Fiscal Year: 2016..The acute phase of cystitis includes inflammation and bladder overactivity resulting from disruption of the urothelial cell (UC) permeability barrier and ..
- Roby Greenwald; Fiscal Year: 2016..response to inhaled oxidants, specifically, the influence of air pollution mixtures on markers of airway inflammation and oxidative stress...
- Jonathan Savitz; Fiscal Year: 2016..b>Inflammation is hypothesized to contribute to depression by altering the breakdown of tryptophan (TRP), the precursor of ..
- JAMES RUSSELL SOWERS; Fiscal Year: 2015..over-nutrition, several other mechanisms, such as enhanced activation of the renin- angiotensin-system (RAS), inflammation, and associated abnormalities in INS metabolic signaling, may help explain the linkage between INS resistance ..
- Pathogenesis and Treatment of Liver Disease in Transaldolase DeficiencyAndras Perl; Fiscal Year: 2013..examine the involvement of TAL deficiency in patients with acetaminophen- induced liver failure, fatty liver inflammation, cirrhosis and HCC...
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2013..their metabolism produces signaling molecules involved in regulating mammalian development, immune function, inflammation and cellular stress responses...
- A Redox-active PARP Inhibitor for Lung TransplantationANDREW LURIE SALZMAN; Fiscal Year: 2012..b>Inflammation is assessed by examining BAL markers of inflammation (protein, PMNs, TNF-[unreadable], and MIP-1[unreadable])...
- Non-viral Genetic Modification of Antigen-presenting Cells in AllograftsWilson S Meng; Fiscal Year: 2011..Rejection will be assessed using florine-19 magnetic resonance imaging to measure in allografts localized inflammation, an early sign of rejection...
- Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to CellsLAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012..Type 2 helper T lymphocytes (Th2) play a critical role in orchestrating allergic airway inflammation. Upon recognition of their cognate antigen, Th2 cells produce cytokines that regulate IgE synthesis (IL-4 and ..
- Enterococcus faecalis, Colorectal Cancer, and Bystander EffectsMark M Huycke; Fiscal Year: 2012..The role of macrophages in the production of inflammation, dysplasia, and tumor formation in E. faecalis colonized mice will be evaluated...
- Norma S Kenyon; Fiscal Year: 2015..MSC are being utilized experimentally and clinically to mediate inflammation and immunity in a variety of settings;however, the impact of MSC MHC in relation to the recipient and to the ..
- METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMENMichael J LaMonte; Fiscal Year: 2013..insulin, and of C-reactive protein and interleukin-6, will be used in defining insulin sensitivity and systemic inflammation, respectively...
- Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related caJose M Garcia; Fiscal Year: 2013..We will establish the role of NF:B and inflammation by exploiting a new transgenic mouse line that has been engineered to express luciferase and green fluorescent ..
- Mark W Chapleau; Fiscal Year: 2015..its potent vasodilator activity, CGRP is involved in many neural processes including nociception, neurogenic inflammation, migraine and anxiety...
- Statin modulation of immunotherapy for Alzheimer diseaseJun Tan; Fiscal Year: 2012..Clinical trials of this therapy were halted because of brain inflammation in subset of cases...
- Investigating Mechanism of Intracellular Rotational Transport with Optical TJeffrey N Anker; Fiscal Year: 2012..to nanoparticle-mediated cytoskeletal oxidation contributes to toxicity via reduced particulate clearance and inflammation. This inflammation and associated overproduction of reactive oxygen species further oxidize RNA/DNA/proteins, ..
- Targeting Inflammation for the Amelioration of Cisplatin-Hearing LossVickram Ramkumar; Fiscal Year: 2011..increase the activity of signal transducers and activators of transcription (STAT1), an important mediator of inflammation. Knockdown of STAT1 reduced the expression of inflammatory genes (such as TNF-a) and protected against ..
- Donald A McClain; Fiscal Year: 2016..funding cycle we determined that serum ferritin, as a measure of tissue iron levels and not as a reflection of inflammation is elevated in diabetes and metabolic syndrome...
- Mitchell Kronenberg; Fiscal Year: 2014..control in Tregs;2) to examine the in vivo function of iTregs in mouse models of autoimmunity and airway inflammation. These studies will significantly advance our understanding of the molecular mechanisms governing Foxp3 gene ..
- Robert T Means; Fiscal Year: 2014..to result from a combination of pathologic processes which can be linked to the cytokine mediators of inflammation. However, the diagnostic importance of altered iron metabolism in ACD has led many investigators to consider ..
- RODNEY JON SCHLOSSER; Fiscal Year: 2014..Both tobacco smoke and DEP are known airborne toxins that cause extensive oxidative inflammation due to free radicals and can lead to exacerbation of allergic rhinitis3...
- A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced NephropathyKanneganti Murthy; Fiscal Year: 2012..ischemia/reperfusion injury R- 801 profoundly reduced the elevation in BUN and creatinine, blocked neutrophil inflammation, and prevented histologic evidence of necrosis...
- DNA methylation of extracellular superoxide dismutase in pulmonary hypertensionEVA NOZIK GRAYCK; Fiscal Year: 2012..pivotal antioxidant enzyme in the vessel wall, identify the role of extracellular superoxide in proliferation, inflammation and fibrosis contributing to pulmonary vascular remodeling, and provide a rationale for novel therapeutic tools ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2013..The central theme of this proposal is that chronic low-grade tissue inflammation is an important underlying etiologic factor leading to decreased insulin sensitivity...
- Inhibition of IkK to treat lethal Graft-vs.-Host DiseasePatrick Flood; Fiscal Year: 2009..treatment or prevention of GVHD have arisen from studies in solid organ transplantation, which does not involve inflammation-inducing conditioning therapy, we believe a new approach that focuses specifically on allo-SCT and the ..
- Alpha B crystallin as a novel therapeutic for SIRS and SepsisJonathan B Rothbard; Fiscal Year: 2011..of the severity of the disease and also support the hypothesis that Cryab has a natural role in modulating inflammation. In addition, Cryab levels in plasma from human trauma patients will be monitored to determine whether this ..
- TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion InjuryLORI ANN HOLLE; Fiscal Year: 2011..with early increased endothelial permeability and edema and later, changes in gene expression, resulting in inflammation. There is growing awareness of the vital role played by the innate immune system in IRI...
- DEBROSKI R HERBERT; Fiscal Year: 2016..Schistosoma mansoni is a major human pathogen affecting 108 people worldwide that causes fibrotic granulomatous inflammation in multiple organ systems...
- Jefferey L Burgess; Fiscal Year: 2014..Exhaled nitric oxide (NO), a marker of airway inflammation, and exhaled carbon monoxide (CO), a marker of CO exposure will both be evaluated...
- Mitzi Nagarkatti; Fiscal Year: 2015..and Th17 cells reactive against myelin antigens, cross the blood-brain barrier (BBB), enter the CNS and trigger inflammation, thereby causing demyelination and induction of paralysis...
- Laura L Dugan; Fiscal Year: 2014..health outcomes in older adults are strongly associated with the development of a state of chronic, mild inflammation. In humans, circulating markers of inflammation, including the inflammatory cytokine interleukin-6 (IL-6), are ..
- Melissa A Rosenkranz; Fiscal Year: 2014..response in asthma (2) quantify the impact of chronic stress on objective measures of lung function and inflammation and (3) evaluate the impact of neural changes, accrued through training in mindfulness, to alter the impact of ..
- Maternal obesity depresses essential fatty acid transport in the placentaPERRIE F O'TIERNEY-GINN; Fiscal Year: 2012..also unknown whether male fetuses and their placentas are more sensitive than females to maternal obesity and inflammation. The overall goal of this proposal is to determine the degree to which maternal obesity alters gender-specific ..
- Monitoring cellular redox signaling and oxidant stress in vivoPaul T Schumacker; Fiscal Year: 2010..injury, vascular disease, stroke, diabetes, neurodegenerative diseases, liver disease, renal disease, inflammation, cancer, and other disorders...
- MATTHEW PETER COGGINS; Fiscal Year: 2014..NF-kB) family of transcription factors regulates a wide range of essential processes in multiple tissues, from inflammation to cell survival...
- KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASERobert Colman; Fiscal Year: 2001..products (proteoglycan-polysaccharide, PG- APS) found in the lower bowel produce chronic granulomatous inflammation similar to Crohn's disease (regional ileitis) in genetically susceptible rats as well as associated systemic ..
- DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung EpitheliumHua Zhao; Fiscal Year: 2009..b>Inflammation has been recognized as an important factor in lung carcinogenesis...
- WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASISDENISA WAGNER; Fiscal Year: 2007..We will explore the role of these granules both in homeostasis and in mouse disease models of acute and chronic inflammation, thrombotic thrombocytopenic purpura and stroke. The project will consist of three interrelated Specific Aims...
- SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATIONKenneth Hargreaves; Fiscal Year: 2003..Our preliminary data indicate that alpha adrenergic agonists inhibit the initiation of neurogenic inflammation, as measured by reduction of capsaicin-evoked release of the pro-inflammatory neuropeptide calcitonin gene-..
- Novel minimally invasive assessment of gastrointestinal inflammation in food alleGlenn Furuta; Fiscal Year: 2009..Long-term consequences of chronic eosinophilic inflammation in EE include esophageal remodeling, with subepithelial fibrosis, and esophageal narrowing and strictures, thus ..
- Novel RNAi Inhibits Both Inflammation and Bone Resorption in Oral DiseasesYi Ping Li; Fiscal Year: 2010..to develop a novel treatment that will simultaneously prevent tissue damage and bone loss by reducing the inflammation and bone resorption caused by oral infectious and inflammatory diseases...
- Lymphangiogenesis and Angiogenesis in Airway InflammationDonald McDonald; Fiscal Year: 2009..examine the mechanisms, consequences, and reversibility of lymphangiogenesis and angiogenesis in chronic airway inflammation. The overall hypothesis is that abnormalities in mucosal lymphatics and blood vessels contribute in multiple ..
- Novel mouse models of inflammation-resolutionPaul L Fox; Fiscal Year: 2010DESCRIPTION (provided by applicant: Chronic inflammation is a major contributor to the onset and progression of atherosclerosis and other vascular disorders...
- S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancerGEETHA K SRIKRISHNA; Fiscal Year: 2010DESCRIPTION (provided by applicant): Clinical and epidemiological studies suggest an association between inflammation and cancer, but the molecular basis of this association is not well understood...
- Pulmonary Biomarkers of Inflammation in Chronic TetraplegiaMiroslav Radulovic; Fiscal Year: 2009..Underlying airway inflammation is the major pathophysiological mechanism in individuals with asthma...
- NEURAL CONTROL OF THE GALLBLADDERGary M Mawe; Fiscal Year: 2010..by applicant): Decreased contractility is a hallmark of gallbladder disorders, and it is associated with inflammation and gallstone formation...
- Domestic endotoxin exposure and chronic obstructive pulmonary diseaseNadia Hansel; Fiscal Year: 2009..leading cause of death in the United States and is a progressive disease characterized by lung injury and inflammation. Unfortunately, smoking cessation has been the only therapeutic intervention proven to slow disease progress ..